Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Fully self-gated dual-venc five-dimensional flow magnetic resonance imaging for simultaneous imaging of the cardiovascular and portal venous systems: A feasibility study.","authors":"Yuyang Ren, Wen Ye, Wenchao Yang, Wenjian Liu, Haotian Hong, Junpu Hu, Jiayu Zhu, Haikun Qi, Fei Shan, Peng Hu, Zijian Zhou","doi":"10.1016/j.jocmr.2026.102750","DOIUrl":"10.1016/j.jocmr.2026.102750","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and evaluate a fully self-gated dual-venc five-dimensional (5D) flow cardiovascular magnetic resonance (CMR) technique for joint assessment of cardiovascular and portal venous hemodynamics under free breathing.</p><p><strong>Methods: </strong>A dual-venc 5D flow sequence using a spiral-in Cartesian sampling trajectory was implemented. Cardiac and respiratory motion were retrospectively resolved using principal component analysis of self-gating signals, followed by total variation regularized reconstruction. The technique was first tested in a custom-built phantom with steady flow and stationary parts, and compared with conventional four-dimensional (4D) flow. It was then evaluated in healthy volunteers and in patients with cirrhosis or portal hypertension, including post-transjugular intrahepatic portosystemic shunt (TIPS) cases. No contrast agent was administered for either the phantom or in vivo scans, with an in vivo 5D flow scan time of approximately 15 min per subject. Hemodynamic parameters in both the cardiovascular and portal venous systems were quantified and compared with conventional breath-held, ECG-triggered two-dimensional (2D) phase-contrast (PC) MRI. For each subject, flow internal consistency (IC) across vessel planes and respiration-resolved flow variations were also computed.</p><p><strong>Results: </strong>Phantom experiments demonstrated an average 67% improvement in velocity-to-noise ratio (VNR) and similar flow quantification compared with fully sampled 4D flow MRI. In vivo evaluation included 12 healthy volunteers, 8 cirrhosis patients, and 9 post-TIPS patients. Across all cohorts, dual-venc 5D flow achieved substantial VNR enhancement (approximately 200% on average), high flow IC (>82%), and strong agreement with 2D PC MRI for both peak and net flow (bias <10%). Respiration-resolved analysis revealed a consistent increase in net flow in the main pulmonary artery (MPA), right pulmonary artery (RPA), and superior vena cava (SVC) during inspiration, along with elevated SVC peak flow.</p><p><strong>Conclusions: </strong>Fully self-gated dual-venc 5D flow MRI enables simultaneous, respiration-resolved quantification of cardiovascular and portal venous hemodynamics within a clinically feasible scan time and with high VNR. This technique provides a promising tool for characterizing systemic hemodynamics in cirrhosis and for evaluating portal-systemic circulatory interactions following TIPS.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102750"},"PeriodicalIF":5.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term carotid plaque progression and the role of intraplaque hemorrhage: A deep learning-based analysis of longitudinal vessel wall imaging.","authors":"Yin Guo, Ebru Yaman Akcicek, Daniel S Hippe, SeyyedKazem HashemizadehKolowri, Xin Wang, Halit Akcicek, Gador Canton, Niranjan Balu, Duygu Baylam Geleri, Taewon Kim, Dean Shibata, Kaiyu Zhang, Beibei Sun, Xiaodong Ma, Marina S Ferguson, Mahmud Mossa-Basha, Thomas S Hatsukami, Chun Yuan","doi":"10.1016/j.jocmr.2025.102670","DOIUrl":"10.1016/j.jocmr.2025.102670","url":null,"abstract":"<p><strong>Background: </strong>Carotid atherosclerosis is a major contributor to the etiology of ischemic stroke. Although intraplaque hemorrhage (IPH) is known to increase stroke risk and plaque burden, its long-term effects on plaque dynamics remain unclear. This study aimed to evaluate the long-term impact of IPH on carotid plaque burden progression using deep learning-based segmentation on multi-contrast magnetic resonance vessel wall imaging (VWI).</p><p><strong>Methods: </strong>28 asymptomatic subjects with carotid atherosclerosis underwent an average of 4.7±0.6 VWI scans over 5.8±1.1 years. Deep learning pipelines were used to segment the carotid vessel walls and IPH. Bilateral plaque progression was analyzed using correlation coefficients and generalized estimating equations. Associations between IPH occurrence, IPH volume, and plaque burden (%WV) progression were evaluated using linear mixed-effect models.</p><p><strong>Results: </strong>IPH was detected in 23/50 of the arteries at any time point. Of arteries without IPH at baseline, 11/39 developed new IPH that persisted, while 5/11 arteries with baseline IPH exhibited it throughout the study. Bilateral plaque growth was significantly correlated (r = 0.54, p<0.001), but this symmetry was weakened in cases with IPH (r = 0.1, p = 0.62). Moreover, IPH presence or development at any point was associated with a 2.3% absolute increase in %WV on average within the affected artery (p<0.001). The volume of IPH was also positively associated with increased %WV (p = 0.005).</p><p><strong>Conclusion: </strong>Deep learning-based segmentation pipelines were utilized to identify IPH, quantify IPH volume, and measure their effects on carotid plaque burden during long-term follow-up. Findings demonstrated that IPH may persist for extended periods. While arteries without IPH demonstrated minimal progression under contemporary treatment, the presence of IPH and greater IPH volume significantly accelerated long-term plaque growth.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102670"},"PeriodicalIF":6.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12808887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Native T1 is independently associated with aerobic exercise capacity in long-term follow-up after mild initial COVID-19 disease (Impression COVID&Heart Study).","authors":"Monika Rozewicz-Juraszek, Stephan Mueller, Midjisuren Ganbat, Carlos Rodriguez Bolanos, Anna Klement, Sonia Antoñana Ugalde, Martin Halle, Eike Nagel, Valentina O Puntmann","doi":"10.1016/j.jocmr.2026.102725","DOIUrl":"10.1016/j.jocmr.2026.102725","url":null,"abstract":"<p><strong>Background: </strong>Exercise intolerance is a common and incapacitating long-term consequence of coronavirus disease (COVID-19), even after mild acute illness. Cardiovascular magnetic resonance (CMR) studies have demonstrated persistent perimyocardial inflammatory abnormalities; however, their relationship with long-term aerobic capacity remains unclear.</p><p><strong>Methods: </strong>In this prospective observational study, individuals without prior structural heart disease underwent standardized CMR, echocardiography, and cardiopulmonary exercise testing (CPET) at least 3 years after the initial COVID-19. The primary endpoint was the association between %-predicted peak oxygen consumption (VO₂peak) (age-sex-body mass index (BMI) adjusted, Study of Health in Pomerania (SHIP) https://doi.org/10.1007/s00103-012-1483-6) and imaging parameters. Secondary analyses included lactate measurements and sex-stratified models.</p><p><strong>Results: </strong>A total of 132 participants (mean age 49±12 years; 68/132 (52%) male) were evaluated 48 months [interquartile range (IQR) 42-53] post-infection. Non-ischemic perimyocardial enhancement was present in 34/132 (26%), whereas two participants had an unrecognized ischemic scar. Male sex, higher BMI, lower age, and higher native T1 were associated with lower %-predicted VO₂peak in univariate models. In multivariate analysis, male sex, lower age, and higher native T1 (β = -0.25 per ms, 95% CI -0.40 to -0.10; p<0.001) remained independent predictors of lower %-predicted VO₂peak. In total, 63/132 (48%) participants demonstrated %-predicted VO₂peak below predicted values. Sex-stratified multivariate analyses showed that higher native T1 (p<0.001) independently associated with lower %-predicted VO₂peak in both men and women, with lower age additionally retained in men. In a lactate-measured subgroup (n = 73), higher resting lactate, higher native T1, male sex, and lower left atrial area were associated with lower %-predicted VO₂peak.</p><p><strong>Conclusion: </strong>In long-term follow-up of individuals with mild initial COVID-19 and no prior structural heart disease, aerobic capacity relative to predicted values was reduced in 48% of participants, particularly in men, and was independently associated with higher myocardial native T1.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102725"},"PeriodicalIF":5.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motion-compensated spin-echo cardiac diffusion tensor imaging in multiple cardiac phases using an ultrahigh gradient strength scanner.","authors":"Shubhajit Paul, Camila Munoz, Pedro F Ferreira, C John Evans, Sonya Foley, Fabrizio Fasano, Derek K Jones, Dudley J Pennell, Sonia Nielles-Vallespin, Andrew D Scott","doi":"10.1016/j.jocmr.2026.102699","DOIUrl":"10.1016/j.jocmr.2026.102699","url":null,"abstract":"<p><strong>Background: </strong>Cardiac diffusion tensor imaging (cDTI) has traditionally relied on inefficient stimulated echo techniques to robustly assess microstructural changes over the cardiac cycle. Ultrahigh gradient strength systems (>80mT/m) allow shorter motion-compensated diffusion encoding. This study compares the ability of high and ultrahigh strength gradient systems to provide systolic and diastolic motion-compensated spin echo (MCSE) cDTI.</p><p><strong>Methods: </strong>Second-order MCSE sequences were developed for a research-only Siemens 3T Connectom (300mT/m maximum gradient amplitude per axis), and breath-hold cDTI was acquired at peak systole and end diastole. Acquisitions used the maximum achievable gradient strength (G_UH, 116mT/m) and also limited to typical high gradient strengths (G_H, 66mT/m based on 80mT/m maximum allowable), giving TE = 48ms and 58 ms, respectively. Data were acquired at 2.8 × 2 .8 × 8mm³, b = 500 s/mm² (8 averages) and b = 150 s/mm² (2 averages) in 6 encoding directions.</p><p><strong>Results: </strong>Twenty-two healthy subjects were recruited. 20/21 and 21/22 systolic acquisitions at G_UH and G_H, respectively, met the >50% criteria of the circumferential myocardium showing the expected transmural variation in helix angle. For G_UH and G_H (16/20) 80% and (16/22) 73% of diastolic acquisitions were successful, respectively. SNR was increased using G_UH compared to G_H (median [IQR]: 12.9 [3.8] vs. 9.6 [2.9], p = 0.0002 diastole, 15.6 [5.9] vs. 12.5 [6.7], p = 0.006 systole). Using G_UH fractional anisotropy was lower in systole (0.349 [0.040] vs. 0.373 [0.019], p = 0.002) and G_UH transmural helix angle gradient (HAG) was steeper in diastole (-0.70 [0.17] vs. -0.55 [0.12] ˚/%, p = 0.04). At both G_UH and G_H, sheetlet angle (|E2A|) was higher in systole than in diastole (30.7 [7.3] vs. 21.3 [6.7]˚ p = 10^-4 and 32.6 [10.9] vs. 26.0 [7.4]˚, p = 0.03, respectively). Differences in HAG between phases were only apparent with G_H (-0.88 [0.23] vs. -0.55 [0.15], p = 10^-4) and differences in the mean diffusivity only with G_UH (1.64 [0.11] vs. 1.52 [0.24] ×10^-3mm²/s, p = 0.002).</p><p><strong>Conclusion: </strong>Ultrahigh-strength gradient systems deliver higher SNR for MCSE and more robust imaging in diastole. While further work is required to further improve the reliability in diastole, at ultrahigh gradient strengths, cDTI using MCSE can identify dynamic changes in the cardiac microstructure. These findings will lead to more widespread use of multiphase MCSE in cDTI clinical research.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102699"},"PeriodicalIF":5.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13207544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular volume fraction associates with long-term outcome in patients with severe symptomatic aortic stenosis: 10-year outcomes of the Regression of Myocardial Fibrosis After Aortic Valve Replacement study.","authors":"Nikoo Aziminia, George D Thornton, Jonathan Bennett, Sucharitha Chadalavada, Rebecca Kozor, Rebecca Schofield, Kush P Patel, Iain Pierce, Peter Kellman, Rhodri Davies, Sveeta Badiani, Guy Lloyd, Mario Cortina Borja, Arantxa González, James C Moon, Thomas A Treibel","doi":"10.1016/j.jocmr.2026.102689","DOIUrl":"10.1016/j.jocmr.2026.102689","url":null,"abstract":"<p><strong>Background: </strong>Diffuse fibrosis is central to the pathophysiology of aortic stenosis (AS), can be assessed using cardiovascular magnetic resonance (CMR) with extracellular volume fraction (ECV%), and is associated with mortality. The relevance of this signal to long-term prognosis remains unclear. We aim to assess predictors of long-term mortality with focus on diffuse fibrosis.</p><p><strong>Methods: </strong>Single-center prospective observational cohort study of patients with severe, symptomatic AS undergoing aortic valve replacement (AVR). Patients were assessed using echocardiography, high-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and CMR, including T1 mapping for ECV% quantification. All-cause mortality was identified using the NHS National Spine Database. Univariable and multivariable Cox regression models were fitted to assess all-cause mortality associations.</p><p><strong>Result: </strong>One hundred and sixty-eight patients (age 72 [65-77] years, 55% [92/168] male) underwent CMR. Over a follow-up period of 9.7 (6.8-10.9) years, 76 deaths occurred. Patients who died had higher ECV% (29.9% vs 27.6%, p = 0.014) and greater late gadolinium enhancement (3.9% vs 2.0%, p = 0.013). Univariable predictors of mortality were age, atrial fibrillation (AF), left atrial area, left atrial volume, total cholesterol, triglycerides, HDL:LDL ratio, non-bicuspid aortic valve, hs-cTnT, NT-proBNP, EuroSCORE II and ECV%. On multivariable regression, age, AF and ECV% remained significant predictors of mortality, independently of sex. AIC indicated that the model with four covariates was preferable to the one also including EuroSCORE II and coronary artery disease, and this result was confirmed by a likelihood ratio test (p=0.387).</p><p><strong>Conclusions: </strong>In the longest follow-up cohort of T1 mapping in severe AS, we demonstrate diffuse fibrosis remains an independent predictor of long-term mortality. Integration of ECV% in baseline risk stratification should be explored further in patients with AS undergoing AVR.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102689"},"PeriodicalIF":5.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13187588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular-arterial coupling parameters predict incident cardiovascular events and mortality in UK Biobank.","authors":"Chaoyang Lin, Yixin Yang, Qianyao Lai, Jiahui Chen, Enhao Wei, Shuyun Wu, Lijun Luo, Maosen Lin, Feng Hu, Lin Fan, Enhui Yao","doi":"10.1016/j.jocmr.2026.102709","DOIUrl":"10.1016/j.jocmr.2026.102709","url":null,"abstract":"<p><strong>Background: </strong>Ventricular-arterial coupling (VAC) is fundamental to cardiovascular efficiency, but its value for predicting cardiovascular disease (CVD) in the general population is unclear. This study aimed to evaluate the predictive value of three novel non-invasive VAC parameters-the ratio of arterial stiffness index to global longitudinal strain (ASI/GLS), estimated pulse wave velocity to GLS (ePWV/GLS), and left ventricular end-systolic volume to stroke volume (LVESV/LVSV)-for incident atrial fibrillation (AF), stroke, heart failure (HF), coronary heart disease (CHD), all-cause and CVD mortality.</p><p><strong>Methods: </strong>We analyzed UK Biobank participants free of baseline significant structural CVD or prior major cardiac surgery. VAC parameters were derived from arterial stiffness metrics and cardiac magnetic resonance (CMR). Associations were assessed using multivariable Cox or Fine-Gray models with false discovery rate (FDR) correction. Incremental prognostic value was evaluated using likelihood ratio tests, C-indices, and continuous net reclassification improvement (NRI).</p><p><strong>Results: </strong>The study included 38,144 participants (mean age 63.5 ± 7.5 years; 47.2% men) with a median follow-up of 4.82 years. After adjustment for clinical features, all three VAC parameters were associated with increased risk of AF, stroke, HF, CHD, all-cause and CVD mortality (except ASI/GLS for CHD). For incident HF, the addition of VAC parameters yielded substantial incremental value, raising C-indices to 0.789-0.835 with NRIs of 11.0%-24.1%. Beyond some respective conventional CMR indices, all three VAC parameters remained independent predictors for incident stroke, whereas ePWV/GLS was specifically independent for incident AF (hazard ratio [HR] 1.19, 95% confidence interval [CI] 1.10-1.29), HF (HR 1.26, 95% CI 1.11-1.43), and CHD (HR 1.11, 95% CI 1.001-1.23). Furthermore, while VAC parameters were independently associated with all-cause mortality regardless of LVEF, their associations with CVD mortality were largely attenuated by LVEF.</p><p><strong>Conclusion: </strong>In the general population, non-invasive VAC parameters predict various adverse cardiovascular outcomes. Incorporating ASI/GLS or ePWV/GLS into traditional risk assessment enhances prognostic value in specific clinical scenarios.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102709"},"PeriodicalIF":5.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetically trained convolutional neural networks for time-resolved aortic segmentation of four-dimensional flow magnetic resonance imaging.","authors":"Gloria Wolkerstorfer, Pietro Dirix, Cosima Jahnke, Ingo Paetsch, Robert Manka, Stefano Buoso, Sebastian Kozerke","doi":"10.1016/j.jocmr.2026.102735","DOIUrl":"10.1016/j.jocmr.2026.102735","url":null,"abstract":"<p><strong>Background: </strong>Supervised learning-based approaches are increasingly used for vessel segmentation in four-dimensional (4D) flow cardiovascular magnetic resonance (CMR). However, their widespread adoption is challenged by the need for diverse, reliably annotated datasets, sensitivity to acquisition and reconstruction settings, and the lack of fully defined ground truth.</p><p><strong>Methods: </strong>In this study, we investigated the use of realistic, fluid mechanics-informed synthetic 4D flow CMR data to train convolutional neural networks for time-resolved aortic segmentation. The availability of fully defined ground-truth vessel geometries in synthetic data enabled quantitative evaluation before evaluation on in vivo data acquired across three scanners with varying field strengths and protocols. Four training strategies were evaluated: one using in vivo data only (R-28) and three based on increasing amounts and diversity of synthetic data (S-28, S-multi, and S-full). Performance was assessed using voxel- and surface-based metrics, including Dice similarity coefficient (DSC), Hausdorff distance (HD), and Bland-Altman analysis.</p><p><strong>Results: </strong>The S-full model achieved the best performance on the in vivo test dataset, with a DSC of 0.956 ± 0.017 and a HD of (1.7 ± 1.5) mm, relative to reference annotations. Bland-Altman analysis of cross-sectional areas showed small biases and narrow limits of agreement, with 1.1% [-10.9, 13.1]% for the ascending aorta and -1.0% [-13.1, 11.1]% for the descending aorta. For the in vivo trained model (R-28) evaluated on synthetic data, relative cross-sectional area measurements yielded biases of 3.1% [-10.9, 17.0]% in the ascending aorta and 4.0% [-8.2, 16.2]% in the descending aorta, relative to synthetic ground truth.</p><p><strong>Conclusion: </strong>This work demonstrates that purely synthetic 4D flow CMR can be used to train neural networks for time-resolved aortic segmentation of in vivo 4D flow CMR data, enabling fully automatic inference and quantitative evaluation against fully defined ground truth.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102735"},"PeriodicalIF":5.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate myocardial T1 mapping at 5T using an improved modified Look-Locker inversion recovery method: A validation study.","authors":"Linqi Ge, Yinuo Zhao, Yubo Guo, Yuanyuan Liu, Yihang Zhou, Haifeng Wang, Dong Liang, Hairong Zheng, Yining Wang, Yanjie Zhu","doi":"10.1016/j.jocmr.2025.101974","DOIUrl":"10.1016/j.jocmr.2025.101974","url":null,"abstract":"<p><strong>Background: </strong>Accurate myocardial T1 mapping at 5T remains a technical challenge due to field inhomogeneity and prolonged T1 values. The aim of this study was to develop an accurate and clinically applicable myocardial T1 mapping technique for 5T magnetic resonance imaging systems and validate its performance in a multicenter study.</p><p><strong>Methods: </strong>The proposed method is based on a 5-(3)-3 modified Look-Locker inversion recovery (MOLLI) sequence, dubbed combined-correction MOLLI (coMOLLI), which corrects for both inversion efficiency and readout-induced signal disturbances. Specifically, coMOLLI employs a radiofrequency spoiled gradient recalled echo (GRE) readout rather than the commonly used balanced steady state free precession (bSSFP) readout. Its signal evolution is modeled to estimate T1 values, which incorporates both inversion efficiency and readout disturbances to improve fitting accuracy. To further enhance accuracy, the inversion pulse was redesigned under hardware constraints and the observed B₀ and B₁ variations over the heart at 5T, using adiabatic hyperbolic secant and tangent/hyperbolic tangent (Tan/Tanh) pulses. The method was validated in phantom experiments, as well as in 21 healthy volunteers and 9 patients.</p><p><strong>Results: </strong>The optimized inversion pulse at 5T is the Tan/Tanh pulse with A = 10 kHz, K_s = 4, k = 22, and T_p = 8 ms. In phantom studies, coMOLLI showed high accuracy versus reference inversion recovery-fast spin echo, yielding relative errors within 5% for all nine vials. In in vivo studies, the average native myocardial T1 values across 21 healthy volunteers were 1468 ± 48 ms, 1514 ± 39 ms, and 1545 ± 50 ms, and blood T1 values were 2182 ± 132 ms, 2124 ± 153 ms, and 2131 ± 158 ms for apical, middle, and base slices, respectively.</p><p><strong>Conclusion: </strong>The coMOLLI method demonstrated high accuracy in phantom studies and feasibility in vivo studies. By adopting the widely used 5-(3)-3 MOLLI acquisition scheme, it shows potential for clinical cardiac imaging at 5T.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101974"},"PeriodicalIF":5.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sotatercept improves right ventricular function but is associated with new or worsening pericardial effusions: a cardiovascular magnetic resonance study in intermediate-high risk pulmonary arterial hypertension.","authors":"Ruta Virsinskaite, Catherine J Beattie, Nina Karia, Tushar Kotecha, Benjamin E Schreiber, Jay Suntharalingam, Robert V MacKenzie Ross, Philip D Hughes, Julian Lentaigne, Ann M Scott-Russell, Victoria Parish, Ganesh Kasavkar, Bianca Dumitru, Gavin Thomas, Marianna Fontana, Vivek Muthurangu, J Gerry Coghlan, Daniel S Knight","doi":"10.1016/j.jocmr.2026.102714","DOIUrl":"10.1016/j.jocmr.2026.102714","url":null,"abstract":"<p><strong>Background: </strong>Sotatercept is a novel drug therapy for pulmonary arterial hypertension (PAH) that significantly reduces clinical worsening and improves exercise capacity, functional class, and pulmonary haemodynamics. This study aims to use cardiovascular magnetic resonance (CMR) to monitor the cardiac response to sotatercept in patients with PAH.</p><p><strong>Methods: </strong>Patients with PAH at intermediate-high or high mortality risk and already on background maximal triple PAH therapies, including parenteral prostacyclin analog for at least 3 months, were offered enrollment to a patient access program for sotatercept at the Royal Free Hospital National Pulmonary Hypertension Service. Baseline and follow-up CMR studies were performed at a median interval of 24 (interquartile range 6) weeks.</p><p><strong>Results: </strong>Eighteen out of 23 patients enrolled in the sotatercept access program underwent baseline and follow-up CMR studies (3 patients paused or discontinued sotatercept prior to 12 weeks; 2 patients were unable to undergo CMR). All 18 patients were stratified as being of intermediate-high mortality risk. Significant improvements were observed in right ventricular (RV) size (RV end-diastolic volume -34±30 mL, p = 0.0023; RV end-systolic volume -27 ± 29 mL, p = 0.0023), RV mass (Z = -2.63, p = 0.016), RV function (RV ejection fraction 5 ± 8%, p = 0.034) and right atrial size (-6 ± 4 cm², p = 0.0023). End-systolic interventricular septal curvature also significantly improved at follow-up (Z = 2.07, p = 0.046), suggesting improvement in RV afterload. Five (28%) patients also had a new-onset (1) or larger (4) pericardial effusion without haemodynamic compromise at follow-up, despite improvements in clinical, biochemical, and CMR metrics of PAH. The median increase in pericardial effusion volume was 69% (full range 33%-203%, Z = 2.0, p = 0.043).</p><p><strong>Conclusion: </strong>CMR tracks improvements in right heart chamber size, mass, and function along with metrics of RV afterload in patients with PAH receiving sotatercept. The improvements in RV size and function met or exceeded the clinically relevant minimally important differences for these CMR-derived metrics in patients with PAH. Routine interval surveillance with CMR in patients receiving sotatercept will also enable surveillance for the off-target finding of new-onset or worsening pericardial effusions.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102714"},"PeriodicalIF":5.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of myocardial infarction by in vivo chemical exchange saturation transfer magnetic resonance imaging using natural D-glucose.","authors":"Ajay Peddi, Daniel Schache, Chris Lippe, Sai Kiran Reddy Samawar, Michael Kuhlmann, Peter Niehaus, Jens Soltwisch, Emily Hoffmann, Ali Nahardani, Stephan Niland, Noelia Alonso Gonzalez, Klaus Dreisewerd, Uwe Karst, Lydia Sorokin, Michael Schaefers, Moritz Wildgruber, Cornelius Faber, Verena Hoerr","doi":"10.1016/j.jocmr.2025.102667","DOIUrl":"10.1016/j.jocmr.2025.102667","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular magnetic resonance (CMR), the gold standard approach for characterizing myocardial infarction (MI), frequently relies on late gadolinium enhancement (LGE) using gadolinium-based contrast agents (GBCA). Whereas novel GBCAs targeting specific molecules have not yet entered clinical practice, chemical exchange saturation transfer (CEST) MRI shows promise for detecting various endogenous molecules. This study explored the potential of natural D-glucose as a biodegradable MRI contrast agent for imaging MI on day 7 by employing glucose-weighted CEST MRI (glucoCEST). METHODS AND RESULTS: In vivo, the application of cardiac glucoCEST MTR_asym (magnetization transfer ratio asymmetry) mapping delineated distinct pre- and postglucose infusion states in both healthy (n = 8) and MI-induced mice (n = 6) at 9.4T. This approach resulted in significant alterations in glucoCEST contrast, effectively identifying MI regions analogous to conventional LGE and immunohistochemical staining. Ex vivo mass spectrometry imaging confirmed elevated ¹³C-glucose and gadolinium accumulation in the MI region after exogenous administration, suggesting the potential of glucoCEST MRI for MI detection.</p><p><strong>Conclusion: </strong>Our preclinical study on MI demonstrated that cardiac glucoCEST MRI utilizing natural D-glucose as a biodegradable contrast agent effectively differentiates between MI regions, remote myocardium (RM), and healthy myocardium. The results were comparable to those obtained using LGE imaging.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"102667"},"PeriodicalIF":6.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12808883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}