Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Highlights of the Society for Cardiovascular Magnetic Resonance (SCMR) 2025 Conference: leading the way to accessible, efficient and sustainable CMR.","authors":"Claudia Prieto, Bradley D Allen, Clerio F Azevedo, Bruno Bezerra Lima, Christopher Z Lam, Rebecca Mills, Merel Huisman, Ricardo A Gonzales, Sebastian Weingärtner, Anthony G Christodoulou, Carlos Rochitte, Michael Markl","doi":"10.1016/j.jocmr.2025.101914","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101914","url":null,"abstract":"<p><p>The 28th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance (SCMR) took place from January 29 to February 1, 2025, in Washington, D.C. SCMR 2025 brought together a diverse group of 1714 cardiologists, radiologists, scientists, and technologists from more than 80 countries to discuss emerging trends and the latest developments in cardiovascular magnetic resonance (CMR). The conference centered on the theme \"Leading the Way to Accessible, Sustainable, and Efficient CMR,\" highlighting innovations aimed at making CMR more clinically efficient, widely accessible, and environmentally sustainable. The program featured 728 abstracts and case presentations with an acceptance rate of 86% (728/849), including Early Career Award abstracts, oral abstracts, oral cases and rapid-fire sessions, covering a broad range of CMR topics. It also offered engaging invited lectures across eight main parallel tracks and included four plenary sessions, two gold medalists, and one keynote speaker, with a total of 826 faculty participating. Focused sessions on accessibility, efficiency, and sustainability provided a platform for discussing current challenges and exploring future directions, while the newly introduced CMR Innovations Track showcased innovative session formats and fostered greater collaboration between researchers, clinicians, and industry. For the first time, SCMR 2025 also offered the opportunity for attendees to obtain CMR Level 1 Training Verification, integrated into the program. Additionally, expert case reading sessions and hands-on interactive workshops allowed participants to engage with real-world clinical scenarios and deepen their understanding through practical experience. Key highlights included plenary sessions on a variety of important topics, such as expanding boundaries, health equity, women's cardiovascular disease and a patient-clinician testimonial that emphasized the profound value of patient-centered research and collaboration. The scientific sessions covered a wide range of topics, from clinical applications in cardiomyopathies, congenital heart disease, and vascular imaging to women's heart health and environmental sustainability. Technical topics included novel reconstruction, motion correction, quantitative CMR, contrast agents, novel field strengths, and artificial intelligence applications, among many others. This paper summarizes the key themes and discussions from SCMR 2025, highlighting the collaborative efforts that are driving the future of CMR and underscoring the Society's unwavering commitment to research, education, and clinical excellence.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101914"},"PeriodicalIF":4.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FlowMRI-Net: A Generalizable Self-Supervised 4D Flow MRI Reconstruction Network.","authors":"Luuk Jacobs, Marco Piccirelli, Valery Vishnevskiy, Sebastian Kozerke","doi":"10.1016/j.jocmr.2025.101913","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101913","url":null,"abstract":"<p><strong>Background: </strong>Image reconstruction from highly undersampled 4D flow MRI data can be very time consuming and may result in significant underestimation of velocities depending on regularization, thereby limiting the applicability of the method. The objective of the present work was to develop a generalizable self-supervised deep learning-based framework for fast and accurate reconstruction of highly undersampled 4D flow MRI and to demonstrate the utility of the framework for aortic and cerebrovascular applications.</p><p><strong>Methods: </strong>The proposed deep-learning-based framework, called FlowMRI-Net, employs physics-driven unrolled optimization using a complex-valued convolutional recurrent neural network and is trained in a self-supervised manner. The generalizability of the framework is evaluated using aortic and cerebrovascular 4D flow MRI acquisitions acquired on systems from two different vendors for various undersampling factors (R=8,16,24) and compared to compressed sensing (CS-LLR) reconstructions. Evaluation includes an ablation study and a qualitative and quantitative analysis of image and velocity magnitudes.</p><p><strong>Results: </strong>FlowMRI-Net outperforms CS-LLR for aortic 4D flow MRI reconstruction, resulting in significantly lower vectorial normalized root mean square error and mean directional errors for velocities in the thoracic aorta. Furthermore, the feasibility of FlowMRI-Net's generalizability is demonstrated for cerebrovascular 4D flow MRI reconstruction. Reconstruction times ranged from 3 to 7minutes on commodity CPU/GPU hardware.</p><p><strong>Conclusion: </strong>FlowMRI-Net enables fast and accurate reconstruction of highly undersampled aortic and cerebrovascular 4D flow MRI, with possible applications to other vascular territories.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101913"},"PeriodicalIF":4.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Three-dimensional aortic geometry mapping via registration of non-gated contrast-enhanced or gated and respiratory-navigated MR angiographies\" [Journal of Cardiovascular Magnetic Resonance 26 (2024) 100992].","authors":"Lydia Dux-Santoy, Jose F Rodríguez-Palomares, Gisela Teixidó-Turà, Juan Garrido-Oliver, Alejandro Carrasco-Poves, Alberto Morales-Galán, Aroa Ruiz-Muñoz, Guillem Casas, Filipa Valente, Laura Galian-Gay, Rubén Fernández-Galera, Ruperto Oliveró, Hug Cuéllar-Calabria, Albert Roque, Gemma Burcet, José A Barrabés, Ignacio Ferreira-González, Andrea Guala","doi":"10.1016/j.jocmr.2025.101904","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101904","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101904"},"PeriodicalIF":4.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cine Cardiac Magnetic Resonance Segmentation using Temporal-spatial Adaptation of Prompt-enabled Segment-Anything-Model: A Feasibility Study.","authors":"Zhennong Chen, Sekeun Kim, Hui Ren, Sunghwan Kim, Siyeop Yoon, Quanzheng Li, Xiang Li","doi":"10.1016/j.jocmr.2025.101909","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101909","url":null,"abstract":"<p><strong>Background: </strong>We propose an approach to adapt a segmentation foundation model, segment-anything-model (SAM), for cine Cardiac Magnetic Resonance (CMR) segmentation and evaluate its generalization performance on unseen datasets.</p><p><strong>Methods: </strong>We present our model, cineCMR-SAM, which introduces a temporal-spatial attention mechanism to produce segmentation across one cardiac cycle. We freeze the pre-trained SAM's weights to leverage SAM's generalizability while fine-tuning the rest of the model on two public cine CMR datasets. Our model also enables text prompts to specify the view type (short-axis or long-axis) of the input slices and box prompts to guide the segmentation region. We evaluated our model's generalization performance on three external testing datasets including a public multi-center, multi-vendor testing dataset of 136 cases and two retrospectively collected in-house datasets from two different centers with specific pathologies: aortic stenosis (40 cases) and heart failure with preserved ejection fraction (HFpEF) (53 cases).</p><p><strong>Results: </strong>Our approach achieved superior generalization in both the public testing dataset (Dice for LV = 0.94 and for myocardium = 0.86) and two in-house datasets (Dice ≥ 0.90 for LV and ≥ 0.82 for myocardium) compared to existing CMR deep learning segmentation methods. Clinical parameters derived from automatic and manual segmentations showed a strong correlation (r ≥ 0.90). The use of both text prompts and box prompts enhanced the segmentation accuracy.</p><p><strong>Conclusion: </strong>cineCMR-SAM effectively adapts SAM for cine CMR segmentation, achieving high generalizability and superior accuracy on unseen datasets.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101909"},"PeriodicalIF":4.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOWARDS UNDERSTANDING THE BALANCED STEADY-STATE FREE PRECESSION SIGNAL INTENSITY CHANGES IN CINE CARDIAC MAGNETIC RESONANCE IMAGING: A PRELIMINARY EVALUATION IN HEALTHY SUBJECTS PRE- AND POSTCONTRAST.","authors":"Tom Dresselaers, Frederik De Keyzer, Alexandru Cernicanu, Jan Bogaert, Peter Gatehouse","doi":"10.1016/j.jocmr.2025.101908","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101908","url":null,"abstract":"<p><strong>Background: </strong>Balanced steady-state free-precession (bSSFP) cines provide excellent contrast for morpho-functional cardiac evaluation. The myocardial cine signal intensity (mcSI) fluctuation during the cardiac cycle has not yet been considered diagnostically relevant, in part because the impact of through-plane motion on the mcSI remains unclear.</p><p><strong>Purpose: </strong>We aim to characterize the mid ventricular pre- and postcontrast bSSFP cyclic mcSI fluctuations in healthy subjects and compare these to Bloch simulations incorporating through-plane motion and to acquisitions in a moving phantom.</p><p><strong>Methods: </strong>Retrospectively-gated mid-ventricular short-axis cine bSSFP images from healthy subjects (n=49) acquired at 1.5 Tesla pre- and early postcontrast were analyzed. First, the mcSI fluctuations during the heart cycle were determined and their timing compared to the radial myocardial motion. Next, pre- versus postcontrast differences were determined during systole, early-diastole and late-diastole. Finally, Bloch simulations and acquisitions in a moving T1 phantom were performed to analyze the through-plane motion effect on the bSSFP and spoiled gradient echo (SGRE) mcSI.</p><p><strong>Results: </strong>The bSSFP mcSI showed a three peak pattern both pre- and postcontrast, corresponding to the contraction and relaxation phases. However, the mcSI peaks showed a time lag versus the times of maximum radial velocity that was larger for the systolic contraction than for the early or late-diastolic relaxation phases. In addition, the shape and amplitude of the systolic and early diastolic mcSI peaks changed significantly post- versus precontrast. Bloch simulations showed an in-vivo-like (regional) three-peak signal profile and similar changes for post- versus precontrast T1 levels. Finally, results in the moving phantom and accompanying simulations confirmed a slice-thickness dependent time lag between the motion and mcSI profile in both bSSFP and SGRE.</p><p><strong>Conclusions: </strong>In healthy subjects before and after contrast, the bSSFP mcSI variation during the heart cycle is characterized by a three-peak pattern associated with the contraction and relaxation phases. However, the delays in timing of these peaks versus the myocardial motion, as well as the differences between pre- and postcontrast, vary with the stage of the heart cycle. Bloch simulations suggest that these mcSI fluctuations are largely determined by the regional through-slice motion. A better understanding of these motion-induced contrast mechanisms may be beneficial to methods exploiting bSSFP myocardial cine SI.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101908"},"PeriodicalIF":4.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Biventricular Function and Left Atrial Volume in a Single 5D Whole-Heart CMR Scan at 0.55T.","authors":"Xavier Sieber, Katherine Binzel, Juliet Varghese, Yingmin Liu, Jerome Yerly, Christopher W Roy, Panagiotis Antiochos, Milan Prsa, Ruud B van Heeswijk, Orlando P Simonetti, Matthias Stuber","doi":"10.1016/j.jocmr.2025.101906","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101906","url":null,"abstract":"<p><strong>Background: </strong>CMR has not seen widespread adoption beyond large urban academic centers. The reasons for this limited uptake include the cost, time-intensive nature and special expertise of CMR. Self-navigated 5D, x-y-z-cardiac-respiratory, free-funning whole-heart CMR using self-navigation (5D CMR) implemented on a low-field clinical scanner may help bridge this gap for bi-ventricular function assessment and left atrium volume index measurement.</p><p><strong>Methods: </strong>Whole-heart 3D radial phyllotaxis bSSFP data were collected in 10 healthy adult subjects. Self-navigation was used to extract respiratory and cardiac motion signals and to generate motion-resolved 5D CMR datasets. The right- and left-ventricular ejection fraction (RVEF and LVEF), left atrial volume index (LAVI), contrast ratio, sharpness, perceived image quality, and total scan durations were ascertained and compared to those obtained with the reference 2D cine images.</p><p><strong>Results: </strong>5D CMR allowed for time-efficient and concordant measurements when compared to the 2D reference method. The 5D CMR images resulted in lower CR on 5D CMR images (3.3 ± 2.9) than on 2D cines (4.7 ± 1.2), and similarly lower perceived image quality (1.8 ± 0.8 for 5D CMR and 3.6 ± 0.9 for the 2D cines). However, the LVEF measurements were similar with no statistically significant differences (Mean: 58 ± 5% for 5D CMR and 59 ± 5% for 2D cine, p = 0.49) and the LoA were low (-2.81% to 3.81%). For the RVEF, the measurements were also in good agreement when RVEF was measured on the axial views (60 ± 3% for 5D CMR and 60 ± 4% for 2D cine, p = 0.85) and the LoA were also low (-2.87% to 3.07%).</p><p><strong>Conclusion: </strong>5D CMR without the need for ECG, breath-holding, navigators, or complex scan planning enables a highly simplified and time-efficient assessment of bi-ventricular cardiac function on a 0.55T clinical system in 7:50min.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101906"},"PeriodicalIF":4.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LV flow kinetics and myocardial deformation following acute infarction: additional predictive value of CMR 4D flow for LV remodeling post-STEMI.","authors":"Christel H Kamani, May Lwin, Ioannis Botis, Mehak Asad, Noor Sharrack, Hadar Schapira, Arka Das, Peter P Swoboda, Sven Plein, Rob J Van der Geest, Erica Dall'Armellina","doi":"10.1016/j.jocmr.2025.101905","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101905","url":null,"abstract":"<p><strong>Background: </strong>The exact mechanism underlying myocardial maladaptive changes post ST-elevation myocardial infarction (STEMI) remains unclear.</p><p><strong>Objectives: </strong>To assess the impact of the tissue-flow interaction on the development of adverse cardiac remodeling 12 months (M) after acute STEMI.</p><p><strong>Materials and methods: </strong>49 first-STEMI patients (M:F=26:13; mean age=58±10) prospectively underwent 3T CMR acutely, at 3M and 12M post-STEMI. The CMR protocol included left ventricular (LV) cine-images for LV end-diastolic (LVEDV) and end-systolic (LVESV) volumes, stroke volume (SV) and ejection fraction (LVEF); 4D-flow; LGE imaging. The 3M outcome measures included: 4D-flow derived LV flow kinetic energy indexed to EDV (KE_iEDV) and functional flow components [LV- KE_iEDV, minimal- KE_iEDV, diastolic- KE_iEDV, and residual volume (RV), retained inflow (RI), delayed ejection (DE), direct flow (DF)]; global radial, circumferential and longitudinal strain (GRS, GCS, GLS) by feature tracking (FT); infarct size (IS). Adverse LV remodeling (LV_remod) was defined by a ≥ 20% increase in LVEDVi at 12M from baseline, in opposition to the non-remodeling group (LV_non-remod). Association between SV, FT-strain, KE and 4D flow parameters were assessed, as well as predictors of adverse remodeling at 12M post-STEMI.</p><p><strong>Results: </strong>There were 23 LV_remod patients. At 3M post-STEMI, LV_remod patients had significantly reduced LVEF, increased IS, abnormal FT-strain, systolic KE_iEDV, DF and RV compared to LV_non-remod patients. Ther was no significant difference in SV between the 2 groups. FT-strain parameters significantly correlated with DF (GRS: r=0.62; GCS: r=-0.67; GLS: r=-0.58, all p<0.001); RV (GRS: r=-0.56; GCS: r=0.51; GLS: r=0.53, all p<0.001); Peak-A-wave KE_iEDV (GRS: r=0.38, p=0.008; GCS: r=-0.30, p=0.038; GLS: r=-0.29, p=0.04); Systolic KE_iEDV (GRS: r=0.31, p=0.033, GLS: r=-0.35, p=0.012). DF outperformed conventional LV function parameters (SV and LVEF) in the LV_remod prediction. DF and IS were the only independent predictors of 12M adverse remodeling after adjustment for LVEF, SV, FT-strain and KE_iEDV parameters.</p><p><strong>Conclusions: </strong>Our study suggests a potential early interaction between FT-strain and 4D-flow parameters post-STEMI leading to the development of adverse remodeling. Within the limitations of our sample size, DF and IS were independent predictors of LV remodelling after adjustment for LVEF, SV, FT-strain and KE parameters. These findings suggest that these parameters may contribute to further risk stratification at 3M for the development of adverse remodeling at 12M post-STEMI, above conventional LV function parameters. Larger studies are needed to confirm these results.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101905"},"PeriodicalIF":4.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Quantification of Regional Blood Flow and Oxygen Delivery to the Brain, Gut, Kidneys, and Lower Extremities in Adolescents with a Fontan Circulation Compared to Biventricular Controls.","authors":"Jennifer Romanowicz, Sungho Park, Jenifer Bunn, Roni M Jacobsen, Brian Fonseca, Jenny E Zablah, Erin K Englund, Alex J Barker, Jesse A Davidson","doi":"10.1016/j.jocmr.2025.101907","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101907","url":null,"abstract":"<p><strong>Background: </strong>Accumulation of progressive extracardiac disease is nearly universal for patients with single ventricle heart disease palliated to a Fontan circulation; however, etiologies are poorly understood. Limited flow reserve in the Fontan circulation may underlie extracardiac disease found in Fontan physiology through reduced oxygen and nutrient delivery to the tissues. This study aimed to determine regional flow volumes and oxygen delivery to key organ systems in children and adolescents with a Fontan circulation.</p><p><strong>Methods: </strong>In 17 Fontan subjects and 14 biventricular controls, regional arterial flow volumes to the carotid, celiac, superior mesenteric, renal, and iliac arteries were quantified with MRI. Arterial oxygen content was calculated using subject hemoglobin level and pulse oximetry, and regional oxygen delivery was calculated using regional flow volume and oxygen content for the above listed arteries. Cardiac output was measured from ascending aorta flow, systemic blood flow from the caval veins, and aorto-pulmonary collateral flow was calculated as the difference between the two. Flows were compared between groups (t-test) and associations were analyzed between flows and with maximal exercise performance on clinical cardiopulmonary exercise testing (Pearson correlation).</p><p><strong>Results: </strong>On average, renal and iliac arterial flows were lower in the Fontan group, compared to controls. Carotid, celiac, and superior mesenteric arterial flows were preserved in the Fontan group. Arterial oxygen content was equivalent between groups, and thus, regional oxygen delivery followed the same pattern as regional flows. Cardiac output was no different between groups, but systemic blood flow was lower in Fontans due to loss of flow to aorto-pulmonary collaterals. Systemic blood flow correlated with iliac flow such that those with the lowest systemic flow had the least amount of iliac flow. Celiac arterial flow correlated with percent-predicted peak oxygen consumption (VO2) on exercise testing.</p><p><strong>Conclusions: </strong>Our results are consistent with a limited flow reserve in the Fontan circulation with sacrifice of iliac arterial flow as global systemic blood flow decreases. Importantly, these data were measured with subjects supine and at rest. Future work requires the addition of exercise to determine how flow to specific organs is affected by increasing metabolic demand from the extremities.</p><p><strong>Data availability: </strong>The data that support the findings of this study are available from the corresponding author, JR, upon reasonable request.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101907"},"PeriodicalIF":4.2,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of obesity on myocardial tissue characteristics in patients with hypertrophic cardiomyopathy: a cardiovascular magnetic resonance-based study.","authors":"Jie Wang, Lutong Pu, Jinquan Zhang, Ruihao Xu, Yang Li, Mengdi Yu, Yangjie Li, Jiajun Guo, Yuanwei Xu, Yu Kang, Yuchi Han, Yucheng Chen","doi":"10.1016/j.jocmr.2025.101903","DOIUrl":"10.1016/j.jocmr.2025.101903","url":null,"abstract":"<p><strong>Background: </strong>Obesity is associated with cardiac steatosis in healthy adults and is independently associated with increased left ventricular (LV) mass and could contribute to the progression of heart failure-related composite events in patients with hypertrophic cardiomyopathy (HCM). However, it is unclear whether the increased LV mass is accompanied by increased fibrosis. We aimed to assess the impact of increased body mass index (BMI) on myocardial tissue characteristics in patients with HCM.</p><p><strong>Methods: </strong>A total of 737 patients with HCM (99 obese, 298 overweight, and 340 normal-weight patients) who underwent cardiovascular magnetic resonance (CMR) imaging were prospectively included. We assessed the relationship between BMI and LV mass, global native T1, extracellular volume, and late gadolinium enhancement (LGE) using CMR. Myocardial tissues from one patient each with obstructive HCM who underwent septal myectomy of the obese, overweight, and normal-weight groups were obtained and stained with red oil O, hematoxylin, and Masson's trichrome.</p><p><strong>Results: </strong>LV mass index (87.2, interquartile range [IQR]: 71.3 to 113.8, 89.4, IQR:75.5 to 111.5, and 104.7, IQR: 86.4 to 123.4 g/m², P < 0.001) was higher in obese and overweight patients with HCM than those with normal weight, but the native T1 was decreased in obese patients with HCM (1324±67 ms, 1308±63 ms, and 1298±67 ms, P < 0.001). In addition, there was no significant difference in LGE extent among the three subgroups (normal weight: 3.7%, IQR: 0 to 9.5%, overweight: 2.7%, IQR: 0 to 7.7%, obese: 3.8%, IQR: 0 to 7.2%, P = 0.194). Multivariable linear regression analyses found that BMI was independently associated with global native T1 (β = -1.918, P = 0.005). Furthermore, myocardial tissues stained with oil red O from three patients showed an increasing extent of fat deposits with BMI, whereas collagen volume fractions were similar.</p><p><strong>Conclusion: </strong>In HCM patients, obesity is associated with increased myocardial mass and decreased native T1, likely reflecting cardiac steatosis in addition to fibrosis. This distinction underscores the potential reversibility of obesity-related myocardial changes through targeted weight management.</p><p><strong>Trial registration: </strong>This prospective cohort study was registered in the Chinese Clinical Trial Registry (URL: http://www.chictr.org.cn; Registry number: ChiCTR1900024094).</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101903"},"PeriodicalIF":4.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free-breathing single-beat exercise cardiovascular magnetic resonance with generative artificial intelligence for evaluation of volumetric and functional cardiac indices: A reproducibility study.","authors":"Fahime Ghanbari, Alexander Schulz, Manuel A Morales, Jennifer Rodriguez, Jordan A Street, Kathryn Arcand, Scott Johnson, Patrick Pierce, Christopher W Hoeger, Connie W Tsao, Warren J Manning, Reza Nezafat","doi":"10.1016/j.jocmr.2025.101901","DOIUrl":"10.1016/j.jocmr.2025.101901","url":null,"abstract":"<p><strong>Background: </strong>Exercise cardiovascular magnetic resonance (Ex-CMR) can reveal pathophysiologies not evident at rest by quantifying biventricular volume and function during or immediately after exercise. However, achieving reproducible Ex-CMR measurements is challenging due to limited spatial and temporal resolution. This study aimed to develop and evaluate a free-breathing, high-spatiotemporal-resolution single-beat Ex-CMR cine enhanced by generative artificial intelligence. We assessed image analysis reproducibility, scan-rescan reproducibility, and impact of the reader's experience on the analysis.</p><p><strong>Methods: </strong>Imaging was performed on a 3T CMR system using a free-breathing, highly accelerated, multi-slice, single-beat cine sequence (in-plane spatiotemporal resolution of 1.9 × 1.9 mm² and 37 ms, respectively). High acceleration was achieved by combining compressed sensing reconstruction with a resolution-enhancement generative adversarial inline neural network. Ex-CMR was performed using a supine ergometer positioned immediately outside the magnet bore. Single-beat cine images were acquired at rest and immediately post-exercise. In a prospective study, the protocol was evaluated in 141 subjects. A structured image analysis workflow was implemented. Four expert readers, with or without prior training in single-beat Ex-CMR, independently rated all images for diagnostic and image quality. The subjective assessment used two 3-point Likert scales. Biventricular parameters were calculated. Inter- and intra-observer reproducibility were assessed. Fifteen healthy subjects were re-imaged 1 year later for scan-rescan reproducibility. Reproducibility was assessed using intraclass correlation coefficient (ICC), with agreement evaluated via Bland-Altman analysis, linear regression, and Pearson correlation.</p><p><strong>Results: </strong>Free-breathing, single-beat Ex-CMR cine enabled imaging of the beating heart within 30 ± 6 s, with technically successful scans in 96% (136/141) of subjects. Post-exercise single-beat cine images were assessed as diagnostic in 98% (133/136), 96% (131/136), 82% (112/136), and 65% (89/136) of cases by four readers (ordered by descending years of Ex-CMR experience). Good image quality was reported in 74% (100/136) to 80% (109/136) of subjects. Biventricular parameters were successfully measured in all subjects, demonstrating good to excellent inter-observer reproducibility. Scan/rescan reproducibility over 1 year, assessed by two independent readers, showed excellent inter-visit ICCs (0.96-1.0) and strong correlations (R² ≥ 0.92, p < 0.001 for left ventricle; R² ≥ 0.95, p < 0.001 for right ventricle).</p><p><strong>Conclusion: </strong>Single-beat Ex-CMR enabled evaluation of biventricular volumetric and functional indices with excellent reproducibility.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101901"},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}