Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Accurate myocardial T1 mapping at 5 T using an improved MOLLI method: A validation study.","authors":"Linqi Ge, Yinuo Zhao, Yubo Guo, Yuanyuan Liu, Yihang Zhou, Haifeng Wang, Dong Liang, Hairong Zheng, Yining Wang, Yanjie Zhu","doi":"10.1016/j.jocmr.2025.101974","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101974","url":null,"abstract":"<p><strong>Background: </strong>Accurate myocardial T1 mapping at 5T remains a technical challenge due to field inhomogeneity and prolonged T1 values. The aim of this study is to develop an accurate and clinically applicable myocardial T1 mapping technique for 5T magnetic resonance imaging (MRI) systems and validate its performance in a multicenter study.</p><p><strong>Methods: </strong>The proposed method is based on a 5-(3)-3 Modified Look-Locker Inversion Recovery (MOLLI) sequence, dubbed combined-correction MOLLI (coMOLLI), which corrects for both inversion efficiency and readout-induced signal disturbances. Specifically, coMOLLI employs a radiofrequency spoiled gradient recalled echo (GRE) readout rather than the commonly used balanced steady-state free precession (bSSFP) readout. Its signal evolution is modeled to estimate T1 values, which incorporates both inversion efficiency and readout disturbances to improve fitting accuracy. To further enhance accuracy, the inversion pulse was redesigned under hardware constraints and the observed B₀ and B₁ variations over the heart at 5T, using adiabatic hyperbolic secant (HSn) and tangent/hyperbolic tangent (Tan/Tanh) pulses. The method was validated in phantom experiments, as well as in 21 healthy volunteers and 9 patients.</p><p><strong>Results: </strong>The optimized inversion pulse at 5T is the Tan/Tanh pulse with A = 10kHz, K_s = 4, k = 22, and T_p = 8 ms. In phantom studies, coMOLLI showed high accuracy versus reference inversion recovery - fast spin echo (IR-FSE), yielding relative errors within 5% for all nine vials. In vivo studies, the average native myocardial T1 values across 21 healthy volunteers were 1468 ± 48 ms, 1514 ± 39 ms, and 1545 ± 50 ms, and blood T1 values were 2182 ± 132 ms, 2124 ± 153 ms, and 2131 ± 158 ms for apical, middle, and base slices, respectively.</p><p><strong>Conclusion: </strong>The coMOLLI method demonstrated high accuracy in phantom studies and feasibility in vivo studies. By adopting the widely used 5-(3)-3 MOLLI acquisition scheme, it shows potential for clinical cardiac imaging at 5T.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101974"},"PeriodicalIF":6.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial Adipose Tissue: When Good Fat Goes Bad.","authors":"Jamey Cutts, Connie W Tsao, Amit R Patel","doi":"10.1016/j.jocmr.2025.101973","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101973","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101973"},"PeriodicalIF":6.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining CMR Reference Standards through Prognostic Validation.","authors":"Zahra Raisi-Estabragh, Matthias G Friedrich","doi":"10.1016/j.jocmr.2025.101970","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101970","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101970"},"PeriodicalIF":6.1,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparametric CMR identifies macrophage NOS2-mediated benefits of preventive SGLT2 inhibition in a mouse model of metabolic heart disease.","authors":"Julia E Bresticker, Caitlin M Pavelec, Thomas P Skacel, John T Echols, R Jack Roy, Leigh A Bradley, Edgar H Macal, Brent A French, André Marette, Christopher M Kramer, Brant E Isakson, Amit R Patel, Matthew J Wolf, Frederick H Epstein","doi":"10.1016/j.jocmr.2025.101972","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101972","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter 2 (SGLT2) inhibitors improve metabolic and cardiovascular outcomes, but the mechanisms remain incompletely understood. We utilized cardiac magnetic resonance (CMR) and complementary methods to investigate whether preventive SGLT2 inhibitor administration attenuates the development of metabolic heart disease in a high-fat, high-sucrose diet (HFHSD) mouse model.</p><p><strong>Methods: </strong>Male wild type (WT) C57BL/6J mice were fed an HFHSD for 18 weeks to induce obesity, coronary microvascular disease, and diastolic dysfunction. WT mice treated preventively with an SGLT2 inhibitor, empagliflozin (EMPA), were compared to untreated WT mice, and mice fed either an HFHSD or standard chow diet with myeloid cell-specific knockout of the Nos2 gene (Nos2^LysMCre) were compared to floxed controls (Nos2^fl/fl). CMR assessed epicardial adipose tissue (EAT) volume, fatty acid composition (FAC), proton density fat fraction (PDFF), and T1, and myocardial perfusion, and strain. EAT FAC, PDFF, and T1 were quantified using an inversion-recovery multi-echo gradient echo sequence and a multi-resonance triglyceride model. EAT volume was quantified using cine images. Myocardial perfusion reserve (MPR) and strain were measured using arterial spin labeling, and displacement encoding with stimulated echoes (DENSE), respectively. Histology and flow cytometry assessed EAT remodeling and macrophage polarization.</p><p><strong>Results: </strong>EMPA treatment reduced EAT volume (0.36 ± 0.18µL/g vs 0.61 ± 0.25µL/g, p < 0.01) and saturated fatty acid fraction (38.81 [32.83-47.71]% vs 48.06 [43.82-52.65]%, p < 0.05), increased EAT T1 (0.799 [0.764-0.859] s vs 0.755 [0.678-0.772] s, p < 0.05), and decreased EAT NOS2⁺ macrophages (34.74 [21.38-42.098^]% vs 46.36 [38.08-61.30]%, p < 0.05) compared to controls. EMPA improved diastolic strain rate (2.96 [2.61-3.99] s^-1 vs 1.68 [1.21-2.80] s^-1, p < 0.01) and adenosine MPR (2.00 ± 0.54 vs 1.37 ± 0.40, p < 0.01) compared to controls. Myeloid cell NOS2 knockout mice fed an HFHSD exhibited improved adenosine MPR (1.90 ± 0.47 vs 1.39 ± 0.38, p < 0.01) compared to floxed controls.</p><p><strong>Conclusions: </strong>In this obesity-related metabolic heart disease model, EMPA treatment prevents cardiometabolic dysfunction by improving EAT quantity and quality, coronary microvascular function, and diastolic function. These benefits are mediated in part through macrophage NOS2.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101972"},"PeriodicalIF":6.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Cardiovascular Magnetic Resonance Evaluation of Progressive Pressure Overload Due to O-ring Induced Ascending Aortic Constriction in Rats.","authors":"Ida Marie Hauge-Iversen, Einar S Nordén, Arne Olav Melleby, Lili Zhang, Ivar Sjaastad, Emil K S Espe","doi":"10.1016/j.jocmr.2025.101969","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101969","url":null,"abstract":"<p><strong>Background: </strong>Aortic stenosis is a debilitating disease characterized by pressure overload and development of myocardial fibrosis. Animal models that mimic this disease are crucial for translational research. Aortic constriction in rats is commonly used to induce pressure overload, but the precise disease progression in the O-ring induced model of ascending aortic constriction has not been thoroughly evaluated. Additionally, identifying early imaging biomarkers that can predict fibrosis could enhance the model's translational relevance. This study aims to evaluate a rat model of progressive pressure overload using cardiovascular magnetic resonance imaging (CMR) by investigating the degree of constriction at different time points and identifying early imaging biomarkers predicting myocardial fibrosis at later stages.</p><p><strong>Methods: </strong>Sprague Dawley rats (n=14) underwent aortic banding with O-rings (inner diameter of 1.5mm or 1.3mm). Sham-operated rats (n=8) served as controls. CMR was performed every fourth week until 20 weeks post-surgery, followed by tissue harvesting and measurements of fibrosis with histology.</p><p><strong>Results: </strong>All banding groups gradually developed left ventricular (LV) hypertrophy, impaired LV diastolic function (increased E/SRe), increased left atrial (LA) size, and impaired LA function (reduced LA ejection fraction and peak LA strain), but preserved LV ejection fraction during the course of study. The tightest constriction exhibited increased LV fibrosis at 20 weeks. LA diameter at 4 weeks independently predicted LV myocardial fibrosis.</p><p><strong>Conclusion: </strong>This animal model mimics the gradual progression of stenosis seen in humans, highlighting its translational potential. Early LA diameter predicted myocardial fibrosis. These findings underscore the model's relevance for studying disease progression in LV pressure overload.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101969"},"PeriodicalIF":6.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a CMR Foundation Model for Multi-Task Cardiac Image Analysis.","authors":"Athira J Jacob, Indraneel Borgohain, Teodora Chitiboi, Puneet Sharma, Dorin Comaniciu, Daniel Rueckert","doi":"10.1016/j.jocmr.2025.101967","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101967","url":null,"abstract":"<p><strong>Background: </strong>Cardiac magnetic resonance (CMR) is a complex imaging modality requiring a broad variety of image processing tasks for comprehensive assessment of the study. Recently, foundation models (FM) have shown promise for automated image analyses in natural images (NI). In this study, a CMR-specific vision FM was developed and then finetuned in a supervised manner for 9 different imaging tasks typical to a CMR workflow, including classification, segmentation, landmark localization, and pathology detection.</p><p><strong>Methods: </strong>A ViT-S/8 model was trained in a self-supervised manner using DINO on 36 million CMR images from 27,524 subjects from three sources (UK Biobank and two clinical centers). The model was then finetuned for 9 tasks: classification (sequence, cine view), segmentation (cine SAX, cine LAX, LGE SAX, Mapping SAX), landmark localization, pathology detection (LGE, cardiac disease), on data from various sources (both public and 3 clinical datasets). The results were compared against metrics from state-of-the-art methods on the same tasks. A comparable baseline model was also trained on the same datasets for direct comparison. Additionally, the effect of pretraining strategy, as well as generalization and few-shot performance (training on few labeled samples) were explored for the pretrained model, compared to the baseline.</p><p><strong>Results: </strong>The proposed model obtained similar performance or moderate improvements to results reported in the literature in most tasks (except disease detection), without any task-specific optimization of methodology. The proposed model outperformed the baseline in most cases, with an average increase of 6.8 percentage points (pp) for cine view classification, and 0.1 to 1.8 pp for segmentation tasks. The proposed method also obtained generally lower standard deviations in the metrics. Improvements of 3.7 and 6.6 pp for hyperenhancement detection from LGE and 14 pp for disease detection were observed. Ablation studies highlighted the importance of pretraining strategy, architecture and the impact of domain shifts from pretraining to finetuning. Moreover, CMR-pretrained model achieved better generalization and few-shot performance compared to the baseline.</p><p><strong>Conclusions: </strong>Vision FM specialized for medical imaging can improve accuracy and robustness over NI-FM. Self-supervised pretraining offers a resource-efficient, unified framework for CMR assessment, with the potential to accelerate the development of deep learning-based solutions for image analysis tasks, even with few annotated data available.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101967"},"PeriodicalIF":6.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Normal Myocardial Microstructure for Healthy Women and Men Cohorts using cDTI with Ultra-High-Performance Gradient MRI Scanner.","authors":"Shi Chen, Danielle Kara, Jaume Coll-Font, Thomas Garret, Robert Eder, Anna Foster, Salva Yurista, Animesh A Tandon, Oussama Wazni, W H Wilson Tang, Deborah Kwon, Christopher T Nguyen","doi":"10.1016/j.jocmr.2025.101966","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101966","url":null,"abstract":"<p><strong>Background: </strong>Women and men have been found to display differences in their cardiovascular anatomy and physiology, including differences in their cellular composition. While studies have shown cellular and molecular changes across sexes, few have performed sex-based studies of myocardial microstructure for healthy subjects. The purpose of this study was to quantify the myocardial microstructure in large healthy cohorts across sexes using in-vivo cardiac diffusion tensor imaging (cDTI) based on a second order motion compensated (M2) single shot spin echo sequence performed on a commercial ultra-high-performance gradient system.</p><p><strong>Methods: </strong>In this single-centered and cross-sectional study, free breathing cDTI with a 2^nd order motion compensated spin echo diffusion-weighted imaging scheme was evaluated in 103 healthy adult subjects (mean age 33.0 years, 52 women) scanned using an MR system with maximum gradient strength of 200 mT/m. The diffusion tensor model was fit to obtain cDTI parameters including mean diffusivity (MD), fractional anisotropy (FA) and helix angle transmurality (HAT).</p><p><strong>Results: </strong>Women and men did not show significantly different distributions of cDTI parameters (MD, FA, and HAT). Healthy subjects scanned with cDTI protocols performed on an MR system with ultra-high performance gradients have an average of 1.51±0.08 µm²/ms for MD, 0.30±0.02 for FA, and -0.77±0.09 °/% for HAT. Furthermore, women were reported to have an average MD 1.52±0.08 µm²/ms, FA 0.30±0.02, HAT -0.76±0.09 °/%. Men presented an average of MD 1.50±0.08 µm²/ms, FA 0.30±0.02, and HAT -0.77±0.09 °/% (p > 0.05 for all cDTI parameters between sexes).</p><p><strong>Conclusion: </strong>This is the first and largest single-center study to investigate cDTI in a large cohort (N>100) of healthy subjects performed with an ultra-high-performance gradient MR system. No significant difference was discovered in MD, FA and HAT between men and women, suggesting biological sex does not impact myocardial microstructure in healthy subjects. Future work using ultra-high performance systems should focus on the evaluation of microstructural changes in patients with cardiovascular disease.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101966"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Magnetic Resonance in the German National Cohort and the Future of Population Imaging Science.","authors":"Zahra Raisi-Estabragh, Adam J Lewandowski","doi":"10.1016/j.jocmr.2025.101963","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101963","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101963"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of T1ρ with native T1 and T2 mapping for detecting oedema in Takotsubo cardiomyopathy.","authors":"Liene Balode, Robert Kelly, David M Higgins, David Gamble, Dana Dawson, P James Ross","doi":"10.1016/j.jocmr.2025.101965","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101965","url":null,"abstract":"<p><strong>Background: </strong>The use of parametric T1 mapping and T2 mapping cardiovascular magnetic resonance (CMR) in takotsubo cardiomyopathy has shown elevated native T1 and T2 relaxation times. In addition to native T1 and T2 mapping, a new native image parametric mapping method using T1 relaxation in the rotating frame (T1ρ) has shown a potential to assess myocardial tissue characterisation. This study aims to compare T1ρ with native T1 and T2 myocardial mapping in takotsubo cardiomyopathy.</p><p><strong>Methods: </strong>T1ρ, T2 and native T1 relaxation times were obtained for fifty-one patients (96% female, mean age 69) diagnosed with takotsubo cardiomyopathy and sixteen healthy subjects (100% female, mean age 41). The baseline scan for the takotsubo cohort was done within three weeks after symptom onset, with follow-up scans carried out on average nine weeks after the baseline scan. Cardiac function and T1ρ, T2, native T1 maps of basal, mid, and apical segments were analysed.</p><p><strong>Results: </strong>A significant increase in T1ρ relaxation time was measured in mid and apical segments for the takotsubo baseline cohort compared to takotsubo follow-up cohort (p=0.0006, p=0.0011, respectively). A significant increase in T1ρ relaxation time was measured in mid and apical segments for the takotsubo baseline cohort compared to the healthy volunteer cohort (p<0.0001, p<0.0001, respectively). Significantly elevated T2 and native T1 relaxation were observed in basal (p=0.0344, p=0.0109, respectively) mid (p<0.0001, p<0.0001, respectively) and apical (p<0.0001, p<0.0001, respectively) segments for takotsubo baseline scans when compared to the takotsubo follow-up cohort. Significant increase in T2 and native T1 relaxation values were also observed in basal (p=0.0038, p<0.0001, respectively), mid (p<0.0001, p<0.0001, respectively) and apical (p<0.0001, p<0.0001, respectively) segments for takotsubo baseline cohort when compared to the healthy volunteer cohort.</p><p><strong>Conclusion: </strong>In patients with Takotsubo cardiomyopathy, T1ρ values were significantly elevated in the mid and apical segments, where oedema is more pronounced. In contrast, both T2 and native T1 values were significantly increased across all three segments-basal, mid, and apical. Consequently, native T1 and T2 mapping showed superior ability to detect oedema compared to T1ρ mapping.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101965"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-heart MR Imaging in One Minute: 3D fast cardiac MRI technique employing the non-Cartesian Ultra-short echo time sequence.","authors":"Pezad Doctor, Munes Fares, Gerald Greil, Tarique Hussain, Qing Zou","doi":"10.1016/j.jocmr.2025.101964","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101964","url":null,"abstract":"<p><strong>Background: </strong>Three-dimensional (3D) cardiovascular magnetic resonance angiography (MRA) produces detailed images of the heart and its vascular surroundings. However, the technique is challenged in clinical settings for pediatric patients primarily due to the uncooperative nature of pediatric patients, especially those at young age. This work is to propose and assess a one-minute 3D whole-heart MRI technique for pediatric patients with congenital heart diseases (CHD) based on a non-Cartesian gradient-echo-based ultra-short echo time (UTE) sequence together with the ferumoxytol contrast.</p><p><strong>Methods: </strong>Both the 3D fast whole-heart MRI sequence and the clinical 3D bSSFP whole-heart sequence were used for acquiring the whole-heart imaging post ferumoxytol contrast. Image quality assessment in reformatted angiograms was performed between the 3D bSSFP and 3D UTE sequence by two readers independently. Statistical analysis was also performed using the paired t-test to assess the statistical significance for image quality. The p-value < 0.05 was considered indicative of a statistically significant difference. Case studies were provided to visually compare images from the proposed technique and the clinical 3D bSSFP sequence.</p><p><strong>Results: </strong>Thirty-eight studies were performed in 38 consecutive children with a mean age of 10 years [range 5 months - 24 years]. The 3D UTE sequence achieved higher scores in 7 of 10 cardiac structures chosen for comparison. Through statistical analysis, it was determined that the 3D UTE sequence offers superior image quality for all pulmonary veins and maintains comparable quality for the superior vena cava, left atrium, and pulmonary arteries compared to the 3D bSSFP sequence. While for left atrial appendage and ventricular anatomy, the 3D bSSFP sequence was found to yield better image quality compared to the 3D UTE sequence.</p><p><strong>Conclusion: </strong>The ferumoxytol enhanced 3D UTE sequence enables whole-heart imaging in less than one minute with clinical-acceptable image quality and hence can be used as a supplemental tool for the 3D bSSFP sequence in clinical practice.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101964"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}