Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Cardiovascular Magnetic Resonance in the German National Cohort and the Future of Population Imaging Science.","authors":"Zahra Raisi-Estabragh, Adam J Lewandowski","doi":"10.1016/j.jocmr.2025.101963","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101963","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101963"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of T1ρ with native T1 and T2 mapping for detecting oedema in Takotsubo cardiomyopathy.","authors":"Liene Balode, Robert Kelly, David M Higgins, David Gamble, Dana Dawson, P James Ross","doi":"10.1016/j.jocmr.2025.101965","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101965","url":null,"abstract":"<p><strong>Background: </strong>The use of parametric T1 mapping and T2 mapping cardiovascular magnetic resonance (CMR) in takotsubo cardiomyopathy has shown elevated native T1 and T2 relaxation times. In addition to native T1 and T2 mapping, a new native image parametric mapping method using T1 relaxation in the rotating frame (T1ρ) has shown a potential to assess myocardial tissue characterisation. This study aims to compare T1ρ with native T1 and T2 myocardial mapping in takotsubo cardiomyopathy.</p><p><strong>Methods: </strong>T1ρ, T2 and native T1 relaxation times were obtained for fifty-one patients (96% female, mean age 69) diagnosed with takotsubo cardiomyopathy and sixteen healthy subjects (100% female, mean age 41). The baseline scan for the takotsubo cohort was done within three weeks after symptom onset, with follow-up scans carried out on average nine weeks after the baseline scan. Cardiac function and T1ρ, T2, native T1 maps of basal, mid, and apical segments were analysed.</p><p><strong>Results: </strong>A significant increase in T1ρ relaxation time was measured in mid and apical segments for the takotsubo baseline cohort compared to takotsubo follow-up cohort (p=0.0006, p=0.0011, respectively). A significant increase in T1ρ relaxation time was measured in mid and apical segments for the takotsubo baseline cohort compared to the healthy volunteer cohort (p<0.0001, p<0.0001, respectively). Significantly elevated T2 and native T1 relaxation were observed in basal (p=0.0344, p=0.0109, respectively) mid (p<0.0001, p<0.0001, respectively) and apical (p<0.0001, p<0.0001, respectively) segments for takotsubo baseline scans when compared to the takotsubo follow-up cohort. Significant increase in T2 and native T1 relaxation values were also observed in basal (p=0.0038, p<0.0001, respectively), mid (p<0.0001, p<0.0001, respectively) and apical (p<0.0001, p<0.0001, respectively) segments for takotsubo baseline cohort when compared to the healthy volunteer cohort.</p><p><strong>Conclusion: </strong>In patients with Takotsubo cardiomyopathy, T1ρ values were significantly elevated in the mid and apical segments, where oedema is more pronounced. In contrast, both T2 and native T1 values were significantly increased across all three segments-basal, mid, and apical. Consequently, native T1 and T2 mapping showed superior ability to detect oedema compared to T1ρ mapping.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101965"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-heart MR Imaging in One Minute: 3D fast cardiac MRI technique employing the non-Cartesian Ultra-short echo time sequence.","authors":"Pezad Doctor, Munes Fares, Gerald Greil, Tarique Hussain, Qing Zou","doi":"10.1016/j.jocmr.2025.101964","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101964","url":null,"abstract":"<p><strong>Background: </strong>Three-dimensional (3D) cardiovascular magnetic resonance angiography (MRA) produces detailed images of the heart and its vascular surroundings. However, the technique is challenged in clinical settings for pediatric patients primarily due to the uncooperative nature of pediatric patients, especially those at young age. This work is to propose and assess a one-minute 3D whole-heart MRI technique for pediatric patients with congenital heart diseases (CHD) based on a non-Cartesian gradient-echo-based ultra-short echo time (UTE) sequence together with the ferumoxytol contrast.</p><p><strong>Methods: </strong>Both the 3D fast whole-heart MRI sequence and the clinical 3D bSSFP whole-heart sequence were used for acquiring the whole-heart imaging post ferumoxytol contrast. Image quality assessment in reformatted angiograms was performed between the 3D bSSFP and 3D UTE sequence by two readers independently. Statistical analysis was also performed using the paired t-test to assess the statistical significance for image quality. The p-value < 0.05 was considered indicative of a statistically significant difference. Case studies were provided to visually compare images from the proposed technique and the clinical 3D bSSFP sequence.</p><p><strong>Results: </strong>Thirty-eight studies were performed in 38 consecutive children with a mean age of 10 years [range 5 months - 24 years]. The 3D UTE sequence achieved higher scores in 7 of 10 cardiac structures chosen for comparison. Through statistical analysis, it was determined that the 3D UTE sequence offers superior image quality for all pulmonary veins and maintains comparable quality for the superior vena cava, left atrium, and pulmonary arteries compared to the 3D bSSFP sequence. While for left atrial appendage and ventricular anatomy, the 3D bSSFP sequence was found to yield better image quality compared to the 3D UTE sequence.</p><p><strong>Conclusion: </strong>The ferumoxytol enhanced 3D UTE sequence enables whole-heart imaging in less than one minute with clinical-acceptable image quality and hence can be used as a supplemental tool for the 3D bSSFP sequence in clinical practice.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101964"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right atrial function is impaired in pediatric pulmonary arterial hypertension: a multi-center cardiac MRI study.","authors":"Kimberley G Miles, Hieu T Ta, Kurt R Bjorkman, Zhiqian Gao, Nicholas J Ollberding, Russel Hirsch, D Dunbar Ivy, Sean M Lang, Michelle Cash, Melissa Magness, Meredith O'Neil, Kimberly Luebbe, Benjamin S Frank, Paul J Critser","doi":"10.1016/j.jocmr.2025.101962","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101962","url":null,"abstract":"<p><strong>Background: </strong>Impaired right atrial (RA) function is strongly predictive of adverse outcomes in adults with pulmonary arterial hypertension (PAH) but remains incompletely understood in pediatric PAH. In this pediatric multicenter retrospective cohort study using cardiac magnetic resonance imaging (CMR), we analyzed RA size and phasic function and its associations with PAH severity.</p><p><strong>Methods: </strong>PAH and control pediatric patients from two centers who underwent CMR from 2010-2023 were identified. RA volumes were measured throughout the cardiac cycle using the single-plane, area-length method on a standard 4-chamber cine sequence. Total, conduit phase, and active phase stroke volume (SVi; indexed to BSA) and ejection fraction (EF) were calculated. A novel marker, the A/C ratio, was calculated as active/conduit SVi. RA size and phasic function measurements were correlated with clinical, hemodynamic, and non-RA CMR metrics of PAH severity and were associated with adverse events (Potts shunt, lung transplant listing/surgery, and/or death) using univariate and bivariate Cox proportional hazards regression analyses. Intra- and interrater reliability was analyzed using intra-class correlation coefficients (ICC).</p><p><strong>Results: </strong>Compared to controls (n=36), children with PAH (n=72) had higher RA volumes, lower conduit phasic function, and higher active phasic function. In PAH patients, minimum RA volume, active SVi, and A/C ratio directly correlated with NT-proBNP and right ventricular (RV) size, filling pressures, and afterload, while they were inversely correlated with exercise capacity and RVEF. RA conduit EF (cEF) correlations were reversed. During median follow-up of 3.2 years [IQR 1.0, 5.9], RA cEF and A/C ratio remained independent predictors of adverse events after adjustment for common metrics of PAH severity on bivariate analysis, including RVEF (RA cEF aHR 0.91 [95% CI: 0.83-0.99]; A/C ratio aHR 1.58 [95% CI: 1.09-2.29]) and indexed pulmonary vascular resistance (RA cEF aHR 0.83 [95% CI: 0.74-0.93]; A/C ratio aHR 1.79 [95% CI: 1.34-2.41]). RA volume measurements had excellent reliability (ICC >0.97).</p><p><strong>Conclusion: </strong>Correlating with disease severity, impaired RA physiology in pediatric PAH is characterized by RA dilation, reduced conduit phasic function and compensatory augmentation of active phasic function. Assessment of RA size and phasic function is feasible and highly reproducible using standard CMR sequences.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101962"},"PeriodicalIF":6.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diastolic Dysfunction in Patients with Fontan Palliation is Associated with Death and Heart Transplantation.","authors":"Edward H Hardison, Christopher C Henderson, Rachel K Duncan, Kristen George-Durrett, James C Slaughter, Ryan D Byrne, Joshua D Chew, Benjamin P Frischhertz, David A Parra, Angela J Weingarten, Jonathan H Soslow, Daniel E Clark","doi":"10.1016/j.jocmr.2025.101961","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101961","url":null,"abstract":"<p><strong>Background: </strong>Adults with Fontan failure (FF) have variable presentations and are often diagnosed late. Reliable predictors of FF are unknown. Diastolic dysfunction may be associated with adverse outcomes late after Fontan palliation.</p><p><strong>Methods: </strong>Fontan patients were compared to healthy controls. FF was defined as death, transplant, diagnosis of protein losing enteropathy, peak VO2 < 50% predicted, or new diuretic requirement. All phases in the short axis plane were contoured to calculate filling and ejection curves. The following variables were measured by cardiac magnetic resonance (CMR): peak filling rate (PFR), peak ejection rate (PER), PFR and PER indexed to end diastolic volume (EDV), time to PFR (tPFR), and time to PER (tPER).</p><p><strong>Results: </strong>Compared to healthy controls (N=96), the Fontan group (N=98) had worse diastolic function as evidenced by decreased PFR and PFR/EDV and increased tPFR. Patients with FF (N=39) had similar ventricular systolic function and volumetrics to the Fontan subjects without failure (NF; N=59). PFR/EDV was significantly reduced and indexed common ventricular mass was significantly higher among FF patients with the most severe adverse outcomes of death or heart transplantation. The prevalence of late gadolinium enhancement was higher in the FF cohort than the NF cohort.</p><p><strong>Conclusions: </strong>CMR can identify diastolic dysfunction in the Fontan population. Patients with Fontan circulation who died or had a combined outcome of death or transplant had worse diastolic function by CMR compared to Fontan patients without death or transplant.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101961"},"PeriodicalIF":6.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic comparison of stress ECG, CMR and SPECT, alone and sequentially, in stable chest pain.","authors":"Giandomenico Bisaccia, Peter P Swoboda, John F Younger, Neil Maredia, Catherine J Dickinson, Julia M Brown, Chiara Bucciarelli-Ducci, Sven Plein, John P Greenwood","doi":"10.1016/j.jocmr.2025.101960","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101960","url":null,"abstract":"<p><strong>Background: </strong>Exercise ECG remains widely performed in the assessment of patients with suspected cardiac chest pain. We aimed to assess the comparative diagnostic and prognostic yield of exercise ECG, single photon emission computed tomography (SPECT) and cardiovascular magnetic resonance (CMR), in a large prospective patient population.</p><p><strong>Methods: </strong>Patients recruited to CE-MARC who had exercise ECG were included and followed up to a median(IQR) of 6.3(0.1,6.8) years. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values, and area under the curve (AUC) for diagnostic accuracy were derived and hazard ratios of MACE for prognostic significance calculated.</p><p><strong>Results: </strong>Of 752 patients in the CE-MARC trial, 580 had exercise ECG and invasive coronary angiography, of which 503 also had SPECT and CMR. At follow-up, a total of 91(15.7%) patients experienced MACE. Using invasive angiography as the reference test, the sensitivity, specificity, PPV and NPV(95%CI) of exercise ECG were 68.3(61.9,74.0), 72.5(67.6,76.9), 61.0(54.8,66.8), 78.4(73.7,82.5). Exercise ECG was significantly less sensitive than CMR and less specific than both CMR and SPECT. A positive exercise ECG result was not predictive of MACE at follow-up (HR 1.14[0.75,1.72], p=0.53). CMR had both a greater diagnostic and prognostic yield than exercise ECG, SPECT and their combination. Sequential CMR following inconclusive exercise ECG was comparable to CMR alone as the first-line test.</p><p><strong>Conclusions: </strong>In patients with suspected angina, CMR alone as the first-line test was more sensitive and prognostically accurate than exercise ECG, SPECT, or sequential combination of both tests.</p><p><strong>Condensed abstract: </strong>In a real-world head-to-head comparison study for diagnostic accuracy and prognostic yield, a strategy of CMR alone outperformed SPECT and exercise ECG, as well as their combination, in patients with stable chest pain. Use of CMR following an inconclusive exercise ECG was superior to use of SPECT, and comparable to a strategy of CMR alone.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101960"},"PeriodicalIF":6.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Magnetic Resonance versus Echocardiography: An analysis examining risk reclassification by left ventricular ejection fraction and cost burden analysis.","authors":"Annie J Tsay, Kinpritma Sangha, Linda Lee, Shuo Wang, Seban Liu, Arslan Zahid, Maria Poonawalla, Roberto M Lang, Christopher M Kramer, Amit R Patel","doi":"10.1016/j.jocmr.2025.101959","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101959","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) is a leading cause of morbidity and mortality in the United States and is projected to increase in the next decade. Left ventricular ejection fraction (LVEF) is used to guide optimal medical therapy and is typically quantified using 2D-transthoracic echocardiography (TTE) due to ease of accessibility and cost. However, LVEF measurements by cardiac magnetic resonance (CMR) are considered the gold standard due to their accuracy and precision. Despite this, CMR is not the first imaging modality selected for LVEF evaluation due to perceptions of long study time, high cost, and inaccessibility. Our study aims to determine the cost of imaging studies (eg, CMR, TTE) relative to the overall HF-related healthcare costs and associated outcomes.</p><p><strong>Methods: </strong>A retrospective single-center cohort study of 420 participants with same day TTE and CMR from 2009-2019 including participants >18 years of age with good image quality with or at risk for cardiovascular disease. Primary outcome was a composite outcome defined as HF admission, left ventricular assist device (LVAD), cardiovascular disease-related death, heart transplantation, and implantable cardioverter defibrillator (ICD) implantation. HF risk groups were determined based on clinically relevant LVEF cutoffs. All costs were calculated and adjusted to 2022 US$.</p><p><strong>Results: </strong>Participants were 49±17 years old, 52% female, 50% White, and 41% Black. Median follow-up was 4 years. HF was the most common co-morbidity (31%). LVEF measured by CMR predicted HF outcomes better than TTE (p=0.005). Continuous net reclassification index of CMR LVEF was 0.36, (95% CI: 0.16-0.56); p=0.001 due to predominant reclassification to lower risk groups. On an individual level, HF healthcare cost increased from low to high-risk groups irrespective of modality. High-risk individuals classified by CMR had lower average per person HF healthcare costs compared to TTE counterparts. Cost of CMR and TTE was < 1% of the total HF healthcare cost.</p><p><strong>Conclusions: </strong>The cost of non-invasive imaging studies accounted for <1% of the cost compared to other components of HF care. Downstream cost prediction based on LVEF classification using CMR has the potential to better predict cost burden compared to TTE in patients with HF.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101959"},"PeriodicalIF":6.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Magnetic Resonance Imaging in the German National Cohort (NAKO): Automated Segmentation of Short-Axis Cine Images and Post-Processing Quality Control.","authors":"Peter M Full, Robin T Schirrmeister, Manuel Hein, Maximilian F Russe, Marco Reisert, Clemens Ammann, Karin Halina Greiser, Thoralf Niendorf, Tobias Pischon, Jeanette Schulz-Menger, Klaus H Maier-Hein, Fabian Bamberg, Susanne Rospleszcz, Christopher L Schlett, Christopher Schuppert","doi":"10.1016/j.jocmr.2025.101958","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101958","url":null,"abstract":"<p><strong>Background: </strong>The prospective, multicenter German National Cohort (NAKO) provides a unique dataset of cardiac magnetic resonance (CMR) cine images. Effective processing of these images requires a robust segmentation and quality control pipeline.</p><p><strong>Methods: </strong>A deep learning model for semantic segmentation, based on the nnU-Net architecture, was applied to full-cycle short-axis cine images from 29,908 baseline participants. The primary objective was to determine data on structure and function for both ventricles (LV, RV), including end-diastolic volumes (EDV), end-systolic volumes (ESV), and LV myocardial mass. Quality control measures included a visual assessment of outliers in morphofunctional parameters, inter- and intra-ventricular phase differences, and time-volume curves (TVC). These were adjudicated using a five-point rating scale, ranging from five (excellent) to one (non-diagnostic), with ratings of three or lower subject to exclusion. The predictive value of outlier criteria for inclusion and exclusion was evaluated using receiver operating characteristics analysis.</p><p><strong>Results: </strong>The segmentation model generated complete data for 29,609 participants (incomplete in 1.0%), of which 5,082 cases (17.0%) underwent visual assessment. Quality assurance yielded a sample of 26,899 (90.8%) participants with excellent or good quality, excluding 1,875 participants due to image quality issues and 835 participants due to segmentation quality issues. TVC was the strongest single discriminator between included and excluded participants (AUC: 0.684). Of the two-category combinations, the pairing of TVC and phases provided the greatest improvement over TVC alone (AUC difference: 0.044; p<0.001). The best performance was observed when all three categories were combined (AUC: 0.748). By extending the quality-controlled sample to include mid-level 'acceptable' quality ratings, a total of 28,413 (96.0%) participants could be included.</p><p><strong>Conclusion: </strong>The implemented pipeline facilitated the automated segmentation of an extensive CMR dataset, integrating quality control measures. This methodology ensures that ensuing quantitative analyses are conducted with a diminished risk of bias.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101958"},"PeriodicalIF":6.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Radiomic Model Based on 7T Intracranial Vessel Wall Imaging for Identification of Culprit Middle Cerebral Artery Plaque Associated with Subcortical Infarctions.","authors":"Tong Chen, Wenhui Zhu, Xiaoyan Bai, Mahmud Mossa-Basha, Yuanbin Zhao, Xun Pei, Xue Zhang, Gaifen Liu, Xingquan Zhao, Zixiao Li, Jie Xu, Shengjun Sun, Duanduan Chen, Shuaitong Zhang, Binbin Sui","doi":"10.1016/j.jocmr.2025.101956","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101956","url":null,"abstract":"<p><strong>Background: </strong>Radiomics has been proven to be an important method for the quantitative assessment atherosclerotic plaques. Therefore, we aimed to evaluate a radiomics approach based on 7.0T high-resolution vessel wall imaging (HR-VWI) to identify culprit middle cerebral artery (MCA) plaques associated with subcortical infarctions.</p><p><strong>Methods: </strong>One hundred patients with MCA plaques were prospectively enrolled. Among these patients, 145 plaques (74 culprit plaques and 71 non-culprit plaques) were included. A traditional model was constructed by recording the conventional radiological plaque characteristics of HR-VWI. Radiomics features from HR-VWI images were utilized to construct a radiomics model. A combined model was built using both conventional radiological and radiomics features. Receiver operating characteristic (ROC) curves and area under curve (AUC) were used to compare the performance of these models.</p><p><strong>Results: </strong>Plaque surface irregularity and superior wall location of MCA plaques were independently associated with subcortical infarctions. The traditional model had AUCs of 0.744 and 0.700 in the training and test sets, respectively. The radiomics and the combined model showed improved AUCs: 0.860 and 0.896 in the training sets and 0.795 and 0.833 in the test sets, respectively. The radiomics model was superior to the traditional model (p=0.042) in the training set. The combined model outperformed the traditional model (training p<0.001, test p=0.048).</p><p><strong>Conclusions: </strong>The radiomics approach based on 7.0T HR-VWI can accurately identify culprit plaques associated with subcortical infarctions, potentially better than conventional HR-VWI features.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101956"},"PeriodicalIF":6.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective electrocardiographic and cardiovascular magnetic resonance alterations in the UK Biobank COVID-19 repeat imaging study.","authors":"Sucharitha Chadalavada, Ahmed Salih, Hafiz Naderi, Elisa Rauseo, Jackie Cooper, Stefan van Duijvenboden, Anwar A Chahal, Gaith S Dabbagh, Liliana Szabo, Mohammed Y Khanji, Jose D Vargas, Mihir Sanghvi, Kenneth Fung, Jose Paiva, Stefan K Piechnik, Betty Raman, Patricia B Munroe, Aaron Mark Lee, Alborz Amir-Khalili, Luca Biasiolli, John P Greenwood, Paul M Matthews, Wenjia Bai, Stefan Neubauer, Nay Aung, Nicholas C Harvey, Zahra Raisi-Estabragh, Steffen E Petersen","doi":"10.1016/j.jocmr.2025.101957","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101957","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular magnetic resonance (CMR) and electrocardiographic (ECG) abnormalities after COVID-19 are widely reported. However, the absence of pre-infection assessments limits causal inference from these studies. This study aims to compare interval change in CMR and ECG measures in participants with incident COVID-19 and matched uninfected controls in UK Biobank.</p><p><strong>Methods: </strong>UK Biobank participants with documented COVID-19 who had CMR and ECG performed prior to the pandemic were invited for repeat assessment, along with uninfected participants matched on age, sex, ethnicity, location, and date of baseline imaging. Automated pipelines were used to extract ECG phenotypes and CMR measures of cardiac structure and function, aortic distensibility, aortic flow, and myocardial native T1. Logistic regression was used to examine associations of baseline metrics with incident COVID-19. Standardized residual approach was used to compare the degree of interval change in CMR and ECG metrics between cases and controls.</p><p><strong>Results: </strong>We analyzed 2,092 participants (1,079 cases, 1,013 controls) with average age of 60±7 years. 47% were male. There was 3.2±1.5 years between pre- and post-infection assessments. 4% of cases were hospitalized. Lower baseline left ventricular ejection fraction and worse longitudinal, circumferential, and radial strain were associated with higher risk of incident COVID-19. There were no significant differences in interval change of any CMR or ECG metric between cases and controls.</p><p><strong>Conclusions: </strong>While pre-existing cardiovascular abnormalities are linked to higher risk of COVID-19, exposure to infection does not alter interval change of highly sensitive CMR and ECG indicators of cardiovascular health.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101957"},"PeriodicalIF":6.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}