Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Age- and sex-differences and reference values for ventricular strain by cardiovascular magnetic resonance imaging in adults without cardiovascular disease or cardiovascular disease risk factors.","authors":"Rohit Pillai, Lu Zhang, Kevin Peters, Vibhav Jha, Christopher J O'Donnell, Warren J Manning, Connie W Tsao","doi":"10.1016/j.jocmr.2025.101902","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101902","url":null,"abstract":"<p><strong>Background: </strong>Myocardial deformation measured by myocardial strain is an important marker of cardiovascular disease (CVD). We aimed to establish normal values and examine age- and sex-differences in left and right ventricular (LV, RV) strain using feature tracking cardiovascular resonance (FT-CMR) in adults free of CVD in the community.</p><p><strong>Methods: </strong>Framingham Heart Study Offspring participants without CVD, hypertension, or diabetes completed CMR (1.5T) (n=903, 59% (533/903) women, 36-88 years of age). Global longitudinal, circumferential, and radial strain (GLS, GCS, and GRS, respectively) were measured by semi-automated LV and RV myocardial segmentation of short-axis, 2-chamber, and 4-chamber images with cvi42 (v.5.13, Circle Cardiovascular Imaging, Calgary, Canada).</p><p><strong>Results: </strong>Mean LV GLS, GCS, and GRS were -17.8±2.5%, -19.7±2.4%, and 34.9±6.9%, respectively; RV GLS, GCS, and GRS were -20.4±4.0%, -11.7±3.5%, and 19.1±6.5%, respectively. All strain values were of greater magnitude in women than men (all p<0.005). LV and RV GCS and GRS were of greater magnitude (more negative and more positive, respectively) with increasing age (all p<0.001), but GLS was not associated with age. Stratified analysis by sex showed LV and RV GCS and GRS were greater in magnitude with increasing age in women (all p<0.001), whereas no age associations in men were observed.</p><p><strong>Conclusion: </strong>We provide FT-CMR reference values for LV and RV strain in a large, community-dwelling U.S. adult cohort free of CVD and CVD risk factors. Women demonstrated greater magnitude LV and RV GCS and GRS with increasing age. The clinical implications of sex-differences in ventricular strain and mechanical remodeling with age deserve further study.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101902"},"PeriodicalIF":4.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Cardiac Magnetic Resonance Imaging for Assessment of Obstructive Coronary Artery Disease - ADVOCATE-CMR Study Rationale and Design.","authors":"Sonia Borodzicz-Jazdzyk, Geoffrey W de Mooij, Alexander den Hartog, Mark B M Hofman, Marco J W Götte","doi":"10.1016/j.jocmr.2025.101900","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101900","url":null,"abstract":"<p><strong>Background: </strong>First-pass stress perfusion cardiovascular magnetic resonance (CMR) imaging is the guidelines-recommended non-invasive test for the detection of obstructive coronary artery disease (CAD). Recently developed quantitative perfusion CMR (QP CMR) allows quantification of myocardial blood flow. Moreover, the latest developments established several methods of CAD assessment without the need for a contrast agent, including stress T1 mapping reactivity (∆T1) and oxygenation-sensitive CMR (OS-CMR). These methods might eliminate the need for contrast administration in clinical practice, reducing time, invasiveness, and costs, thereby simplifying the evaluation of patients with suspected obstructive CAD. The ADVOCATE-CMR study aims to validate QP CMR, ∆T1 and OS-CMR imaging against invasive fractional flow reserve (FFR) for the detection of obstructive CAD. The study also aims to head-to-head compare the diagnostic accuracy of these CMR techniques with the conventional visual assessment of stress perfusion CMR and to correlate them to short- and long-term clinical outcomes.</p><p><strong>Study design: </strong>ADVOCATE-CMR is a single-center, observational, prospective, cross-sectional cohort study. The study will enroll 182 symptomatic patients with suspected obstructive CAD scheduled for invasive coronary angiography (ICA). Before ICA, all participants will undergo CMR imaging including OS-CMR with breathing maneuvers, rest and adenosine stress T1 mapping and rest and adenosine stress first-pass perfusion. Subsequently, ICA will be performed including FFR, instantaneous wave-free ratio (iFR), resting Pd/Pa, coronary flow reserve (CFR) and index of microvascular resistance (IMR) measurements in all main coronary arteries. A follow-up CMR scan with the same protocol will be performed at 3 months after ICA. Clinical follow-up will be performed at 3, 6 months, 1 and 3 years after ICA.</p><p><strong>Conclusion: </strong>The ADVOCATE-CMR will be the first study comprehensively evaluating and comparing head-to-head the diagnostic performance of a range of contrast- and non-contrast agent-based CMR imaging methods (including QP CMR, ∆T1 and OS-CMR) for the detection of FFR-defined obstructive CAD. We expect to establish a validated and time-efficient diagnostic workflow available to a wide range of general CMR services. Finally, these improvements may enable CMR to become an effective non-invasive, radiation-free gatekeeper for ICA in patients with suspected obstructive CAD, potentially without the need for a contrast agent.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101900"},"PeriodicalIF":4.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two decades after the arterial switch operation: stable right ventricular function but reduced exercise capacity.","authors":"R S Joosen, M C van de Veerdonk, A E Bohte, T Takken, A van Wijk, M G Dickinson, G J Krings, M Voskuil, J M P J Breur","doi":"10.1016/j.jocmr.2025.101899","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101899","url":null,"abstract":"<p><strong>Background: </strong>Right ventricular (RV) function and exercise capacity predict prognosis in transposition of the great arteries (TGA) after arterial switch operation (ASO).</p><p><strong>Aim: </strong>To longitudinally evaluate RV dimensions, global function and exercise capacity after ASO, comparing patients with and without RV pressure overload.</p><p><strong>Methods: </strong>This retrospective study included TGA patients post-ASO with two CMRs at the University Medical Center Utrecht between 2004 and March 2024. Cardiac volumes, function, strain and vessel dimensions were measured. Patients were categorized by RV pressure overload. Repeated exercise tests were performed in a subset. The first and second CMR were compared.</p><p><strong>Results: </strong>The cohort (111 patients, 22±8 years; 71% male) underwent the first CMR at median 13 [11-19] years post-ASO (mid-term follow-up) and the second at 21 [16-26] years post-ASO (long-term follow-up).RV volumes, function and strain remained stable during long-term follow-up. Aortic root dimensions showed no progression during long-term follow-up (diameter: 23±5mm/m² vs. 20±4mm/m², p<0.001). 56 out of 111 patients (50%) underwent exercise testing, revealing a VO2peak decline, with 25% having reduced VO2peak at mid-term follow-up and 46% at long-term follow-up (mean age 21±7 years) (p=0.012). This was not related to peak heart rate or chronotropic index (peakHR: R=0.115, p=0.413; chronotropic index: R=0.099, p=0.484). No differences were observed between patients with and without RV pressure overload.</p><p><strong>Conclusion: </strong>Long-term exercise capacity is impaired in a significant portion of TGA patients. RV volumes, global function, strain and aortic root dimensions remained unchanged during long-term follow-up post-ASO.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101899"},"PeriodicalIF":4.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free-breathing, non-contrast, three-dimensional whole-heart coronary magnetic resonance imaging for the identification of culprit and vulnerable atherosclerotic plaque.","authors":"Reza Hajhosseiny, Adam Hartley, Graham Cole, Camilla Munoz, Amarjit Sethi, Rasha Al-Lamee, Saud Khawaja, Sameer Zaman, James Howard, Deepa Gopalan, Ben Ariff, Raffi Kaprielian, Radhouene Neji, Karl P Kunze, Amit Kaura, Claudia Prieto, Ramzi Khamis, René M Botnar","doi":"10.1016/j.jocmr.2025.101898","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101898","url":null,"abstract":"<p><strong>Background: </strong>Detection of vulnerable coronary plaque can predict future myocardial infarctions. We have developed a novel, non-contrast cardiovascular magnetic resonance sequence (iT2prep-BOOST), enabling simultaneous, co-registered coronary angiography and plaque detection.</p><p><strong>Objectives: </strong>To validate iT2prep-BOOST in patients with non-ST-segment elevation myocardial infarction (NSTEMI).</p><p><strong>Methods: </strong>41 patients with suspected NSTEMI were recruited. Invasive coronary angiography ± intravascular imaging was used to classify coronary segments into the following categories: normal, non-culprit and culprit segments; stenosed segments as well as segments with vulnerable plaque features (lipid, calcium, fibroatheroma, thin cap fibroatheroma (TCFA), plaque-rupture and thrombus). The plaque/myocardial signal intensity ratio (PMR) in each coronary segment was analyzed on iT2prep-BOOST.</p><p><strong>Results: </strong>The mean ± standard deviation PMR of culprit segments was significantly higher than non-culprit segments and normal segments (1.01±0.14 vs. 0.67±0.18 vs. 0.35±0.24, P<0.001, respectively). Coronary segments with lipid, calcium, and fibroatheroma had a significantly higher PMR compared to normal coronary segments (P<0.001), but significantly lower than segments with plaque-rupture and intraluminal thrombus (P<0.05). There was a progressive increase in PMR with increasing coronary segment stenosis (P<0.001). There was a significant association on multivariable analysis between HbA1c as well as family history of coronary artery disease and mean PMR (P=0.05 and P=0.04, respectively).</p><p><strong>Conclusion: </strong>iT2prep-BOOST has the potential to simultaneously visualize coronary artery lumen and plaque and differentiate normal segments from non-culprit and culprit plaque segments non-invasively and without contrast. The prognostic value of PMR needs to be investigated in a prospective multicenter study.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101898"},"PeriodicalIF":4.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial native T1 and extracellular volume measurements at 5T: Feasibility study and initial experience.","authors":"Yubo Guo, Lu Lin, Keting Xu, Shihai Zhao, Gan Sun, Yuyan Chen, Ke Xue, Yuxin Yang, Shuo Chen, Yan Zhang, Yanjie Zhu, Yining Wang","doi":"10.1016/j.jocmr.2025.101896","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101896","url":null,"abstract":"<p><strong>Background: </strong>T1 mapping is a robust and highly reproducible technique for quantitative assessment of cardiomyopathy. The aim of this study is to investigate the feasibility of 5T myocardial T1 mapping and to establish preliminary reference values for myocardial T1 at 5T.</p><p><strong>Methods: </strong>Twenty-eight healthy volunteers (median age, 42 [interquartile range (IQR): 29-54] years; 14 male) and 11 patients (median age, 44 [IQR: 34-51] years; 7 male) underwent cardiovascular magnetic resonance at 5T. T1 mapping was acquired using a motion-corrected modified Look-Locker inversion recovery sequence [5(3)3 scheme for pre-contrast, (4(1)3(1)2) scheme for post-contrast] in three short-axis planes (base, middle, and apex). T1 values were quantified per segment, per slice, and globally.</p><p><strong>Results: </strong>Healthy volunteers had a mean global native T1 value of 1506.2 ± 41.7 ms, with T1 values decreasing progressively from the base to the apex slice (P = 0.08). Significantly higher T1 values were revealed in the septum compared to the non-septal myocardium (1540.1 ± 69.3 vs 1477.6 ± 93.7, P < 0.001). No statistically significant gender- and age-related differences were observed in native T1 values (both, P > 0.05). Within the spectrum of cardiac pathologies analyzed in this study, patients exhibited higher native T1 values (1638.7 ± 108.6 ms vs 1506.2 ± 41.7 ms, P < 0.001) and higher extracellular volume fraction (37.5% ± 5.5% vs 29.5% ± 2.1%, P = 0.074) compared to healthy volunteers, late gadolinium enhancement (LGE)-positive segments exhibited significantly higher T1 values than LGE-negative segments (1685.2 ± 144.1 vs 1582.6 ± 88.7, P < 0.001). There was excellent intra-scanner test-retest, intra-observer, and inter-observer reproducibility for measurement of native T1.</p><p><strong>Conclusion: </strong>The present study demonstrated the feasibility of T1 mapping quantification at 5T and presented mean native T1 values in healthy human myocardium at this field strength, which can be used as reference values specific for this magnetic resonance setting.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101896"},"PeriodicalIF":4.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D motion corrected free-breathing SMS-bSSFP myocardium perfusion imaging.","authors":"Naledi Adam, Ronald Mooiweer, Andrew Tyler, Karl Kunze, Radhouene Neji, Peter Speier, Daniel Stäb, John Ng, Shino Kuriakose, Reza Razavi, Muhummad Sohaib Nazir, Amedeo Chiribiri, Sébastien Roujol","doi":"10.1016/j.jocmr.2025.101897","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101897","url":null,"abstract":"<p><strong>Background: </strong>To develop a 3D motion-corrected simultaneous multislice (SMS)-bSSFP acquisition to enable free-breathing myocardial perfusion with high spatial resolution and coverage.</p><p><strong>Methods: </strong>A fast diaphragmatic respiratory navigator (fastNAV) module (<15ms) was implemented into a SMS-bSSFP sequence for prospective slice-tracking. The remaining 2D in-plane motion was corrected using inline image registration. This approach (SMS-fastNAV) was compared to a reference SMS perfusion with 2D in-plane motion correction only (SMS-Ref) in 10 patients at 1.5T. Each subject underwent both perfusion protocols (6 slices, resolution: 1.9×1.9mm²) in a random order. The residual motion of the left ventricular (LV) was assessed by measuring the average DICE coefficient of the LV (avDICE) and the average displacement of the LV centre of mass location (avCOM). Subjective assessment of image quality was also performed.</p><p><strong>Results: </strong>SMS-fastNAV led to lower residual LV motion than SMS-Ref before non-rigid image registration as shown by a higher avDICE (0.93±0.02 vs. 0.89±0.04, p<0.002) and decreased avCOM (2.82±0.89mm vs. 4.23±1.29mm, p=0.005). After non-rigid image registration, SMS-fastNAV also led to higher avDICE score (0.95±0.01 vs. 0.94±0.02, p<0.027) and tended to decrease avCOM (0.97±0.21mm vs. 1.01±0.25mm, p=0.23) with respect to SMS-Ref, suggesting a reduction in through-plane motion. There were no statistical significant differences between both approaches in terms of image quality (SMS-fastNAV: 1.79±0.50 vs. SMS-Ref: 2.00±0.59^, p=0.172).</p><p><strong>Conclusion: </strong>A 3D motion correction strategy was successfully developed for free-breathing SMS-bSSFP perfusion with high spatial coverage and resolution and provides improved motion correction with respect to standard in-plane image registration only.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101897"},"PeriodicalIF":4.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated real-time cine and flow under in-magnet staged exercise.","authors":"Preethi S Chandrasekaran, Chong Chen, Yingmin Liu, Syed Murtaza Arshad, Christopher Crabtree, Matthew Tong, Yuchi Han, Rizwan Ahmad","doi":"10.1016/j.jocmr.2025.101894","DOIUrl":"10.1016/j.jocmr.2025.101894","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular magnetic resonance (CMR) imaging is a well-established imaging tool for diagnosing and managing cardiac conditions. The integration of exercise stress with CMR (ExCMR) can enhance its diagnostic capacity. Despite recent advances in CMR technology, quantitative ExCMR during exercise remains technically challenging due to motion artifacts and limited spatial and temporal resolution.</p><p><strong>Methods: </strong>This study investigated the feasibility of biventricular functional and hemodynamic assessment using real-time (RT) ExCMR during a staged exercise protocol in 24 healthy volunteers. We employed high acceleration rates and applied a coil-reweighting technique to minimize motion blurring and artifacts. We further applied a beat-selection technique that identified beats from the end-expiratory phase to minimize the impact of respiration-induced through-plane motion on cardiac function quantification. Additionally, results from six patients were presented to demonstrate clinical feasibility.</p><p><strong>Results: </strong>Our findings indicated a consistent decrease in end-systolic volume and stable end-diastolic volume across exercise intensities, leading to increased stroke volume and ejection fraction. The selection of end-expiratory beats modestly enhanced the repeatability of cardiac function parameters, as shown by scan-rescan tests in nine volunteers. High scores from a blinded image quality assessment indicated that coil reweighting effectively minimized motion artifacts.</p><p><strong>Conclusion: </strong>This study demonstrated the feasibility of RT ExCMR with in-magnet exercise in healthy subjects and patients. Our results indicate that high acceleration rates, coil reweighting, and selection of respiratory phase-specific heartbeats enhance image quality and repeatability of quantitative RT ExCMR.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101894"},"PeriodicalIF":4.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic failure mode evaluation using non-linear phase contrast correction to improve flow measurement accuracy in cardiovascular magnetic resonance phase contrast imaging.","authors":"Ana Beatriz Solana, Savine C S Minderhoud, Piotr A Wielopolski, Juan Antonio Hernandez-Tamames, Ricardo P J Budde, Willem A Helbing, Martin A Janich, Alexander Hirsch","doi":"10.1016/j.jocmr.2025.101895","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101895","url":null,"abstract":"<p><strong>Background: </strong>Phase contrast (PC) cardiovascular magnetic resonance (CMR) is clinically used to quantify flow. The quantification accuracy is diminished by background phase errors. Image-based background phase correction algorithms are commercially available, but their accuracy is still under evaluation. Here, we validate a recently developed non-linear phase contrast correction (nPCcor) algorithm that includes automatic failure mode classification in a large single-vendor multi-scanner retrospective study.</p><p><strong>Methods: </strong>Three hundred forty-six through-plane PC images at the aortic valve (AAo) and pulmonary artery (PA) were acquired on three different GE HealthCare 1.5T clinical MRI scanners. Each PC scan was repeated on a static phantom, and the static phantom-corrected PC series was considered as the reference standard. Two image-based static tissue background phase corrections were applied on each PC series: a linear and the nPCcor. Accuracy of nPCcor was studied by comparing the net flow in the vessel of interest for the uncorrected, linear-corrected, and nPCcor images with respect to the static phantom-corrected series. Accuracy was defined as a difference in net flow ≤10% with respect to the static phantom corrected net flow.</p><p><strong>Results: </strong>Flow measurements using the nPCcor images after nPCcor automatic classification were found to be accurate for 87% (281/323) of PC datasets, 6% and 17% better than using uncorrected and linear-corrected (p<0.05), respectively. Most importantly, nPCcor was able to correctly identify 70% (16/23) PC cases likely to provide inaccurate flow measurements. Flow measurements after nPCcor in the scanner with the largest phase offsets were found to be accurate for 74% (62/84) of PC datasets, 22% better than using the uncorrected images (p<0.05). nPCcor correction was statistically significant more accurate than linear correction for all scanners (p<0.05). The percentage of regurgitation reclassification of ≥1 category decreased to 8% (8/323) after nPCcor correction, 3% better than for uncorrected images.</p><p><strong>Conclusion: </strong>nPCcor with automatic failure mode evaluation improved accuracy with respect to no correction and linear correction and successfully identified PC scans that are likely to result in unreliable flow measurements. nPCcor performance and phase offset errors varied greatly among scanners using the same CMR protocol. nPCcor has higher impact in scanners exhibiting the largest background phase offsets.</p><p><strong>Trial registration: </strong>observational study.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101895"},"PeriodicalIF":4.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac function evaluation in healthy volunteers and patients with implantable cardioverter-defibrillators using high-bandwidth spoiled gradient-echo cine.","authors":"Calder D Sheagren, Naseem Shadafny, Terenz Escartin, Maria Terricabras, Christopher C Cheung, Idan Roifman, Graham A Wright","doi":"10.1016/j.jocmr.2025.101893","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101893","url":null,"abstract":"<p><strong>Background: </strong>Implantable cardioverter-defibrillators (ICDs) cause banding artifacts around areas of B₀ inhomogeneity in conventional steady-state free precession (SSFP) cine sequences. Alternatively, high-bandwidth gradient-recalled echo (GRE) cine sequences can be used to minimize artifacts in the myocardium. In this study, we assessed the bias and interobserver variability in cardiac volumes and ejection fractions between GRE cines in acquired in the presence of ICDS and ground-truth SSFP cines (without ICDs present) in a population of healthy volunteers. Further, a small cohort of ICD patients was recruited and scanned to demonstrate clinical feasibility.</p><p><strong>Methods: </strong>High-bandwidth GRE cine was performed in 11 healthy volunteers with taped ICDs mimicking clinical implants. After the ICD was removed, ground-truth SSFP cine was performed. Two observers separately assessed image quality metrics and contoured the cine images to return cardiac volumes and ejection fractions. Nine patients with an ICD were also scanned with the GRE cine protocol before contrast administration; data were contoured by two observers and analyzed for interobserver agreement.</p><p><strong>Results: </strong>In the healthy volunteer dataset, no statistically significant differences were found when comparing volumes or ejection fractions between sequences (p > 0.05). Statistically significant differences were found when comparing right ventricular ejection fraction (RVEF) (p = 0.009) and right ventricular end-systolic volume (p = 0.029) between observers, with no other significant interobserver differences. The interobserver variability of patient left ventricular ejection fraction and RVEF data was 3-4%, with lower image quality metrics for patient scans than volunteer scans.</p><p><strong>Conclusion: </strong>GRE cine imaging in healthy volunteers with taped ICDs demonstrated good agreement with SSFP cine, but increased interobserver variability. In patients, reducing the breath-hold duration caused a decrease in image quality, with GRE cine imaging in patients with ICDs demonstrating poorer image quality and greater interobserver variability than in healthy volunteer studies. Future work is needed to improve GRE cine image quality in patients with ICDs to reduce interobserver variability and improve clinical confidence.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101893"},"PeriodicalIF":4.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical use of cardiovascular magnetic resonance-defined synthetic extracellular volume fraction.","authors":"David A Bluemke, Prashant Nagpal","doi":"10.1016/j.jocmr.2025.101891","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101891","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101891"},"PeriodicalIF":4.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}