Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Mitral annular disjunction distance is associated with adverse outcomes in children and young adults with connective tissue disorders.","authors":"Daniel A Castellanos, Spencer B Barfuss, Noah DiBiasio-Hudson, Grace Lee, Elizabeth DeWitt, Edward T O'Leary, Lynn A Sleeper, Chrystalle Katte Carreon, Stephen P Sanders, Daniel Quiat, Michael N Singh, Sunil J Ghelani, Ronald V Lacro","doi":"10.1016/j.jocmr.2025.101954","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101954","url":null,"abstract":"<p><strong>Introduction: </strong>Mitral annular disjunction (MAD) is a pathologic fibrous separation of the mitral valve hinge point from the ventricular myocardium. The aims of this study were to describe the range of MAD distance by cardiac magnetic resonance (CMR) in children and young adults with connective tissue disorders (CTDs) versus a healthy control sample, and to assess the MAD distance as a predictor of adverse cardiovascular outcomes.</p><p><strong>Methods: </strong>This was a retrospective, single-center study of healthy subjects and patients with Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, or nonspecific CTD who underwent CMR between 01/01/2000 and 01/01/2020. The MAD distance was measured from the 2-chamber, 4-chamber, and left ventricular outflow tract views in systole and diastole and analyzed as absolute values as well as indexed to BSA and height. The primary outcome was a composite defined as the presence of significant ventricular arrhythmias, cardiac arrest, and/or death. Age-adjusted odds ratios with 95% confidence intervals and c-statistic are reported. Classification and Regression Tree analysis was performed to identify the most discriminating binary threshold to predict occurrence of the composite outcome.</p><p><strong>Results: </strong>30 healthy control subjects and 254 patients with CTD met inclusion criteria. The mean ± SD age at initial CMR was 17±6 years for patients with CTD and 14±3 years for controls. The mean MAD distance was larger in patients with CTD compared to the control sample, and the maximum MAD distance in the control sample was 3.6mm. Median follow-up in the CTD group was 5 years (IQR 3-11 years). Thirty-four (15%) patients met the composite outcome. Systolic MAD distance was positively associated with the composite outcome. The optimal binary threshold for height-indexed maximum systolic MAD distance was 0.033mm/cm with an event rate of 18.6% at/above threshold versus 2.6% below threshold (AUC 0.74). The association was independent of other important clinical predictors.</p><p><strong>Conclusions: </strong>A small MAD distance can be measured in healthy children and young adults. Children and young adults with CTD have a longer MAD distance than healthy control subjects, and a longer MAD distance is associated with adverse outcomes.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101954"},"PeriodicalIF":6.1,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Free-Breathing Cardiac MRI: Enhancing Efficiency and Image Quality in Clinical Practice.","authors":"Kai Yang, Chen Cui, Fei Teng, Gang Yin, Jing An, Xinling Yang, Jinghui Li, Xiaoming Bi, Jianing Pang, Kelvin Chow, Shihua Zhao, Minjie Lu","doi":"10.1016/j.jocmr.2025.101955","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101955","url":null,"abstract":"<p><strong>Background: </strong>Conventional cardiac magnetic resonance (CMR) examinations require patients to repeatedly hold their breath, which can reduce examination efficiency and pose challenges for patients unable to do so. This study aimed to demonstrate the feasibility and effectiveness of a full free-breathing CMR protocol in clinical practice.</p><p><strong>Methods: </strong>Patients prospectively enrolled in this study underwent a full free-breathing CMR exam on a 3T scanner between June 1 and June 30, 2024. Acquisition time and image quality were assessed. Cine and flow imaging were compared with those acquired with the conventional breath-holding CMR protocol. Other sequences, including T1/T2 mapping and late gadolinium enhancement (LGE), were evaluated quantitatively and qualitatively, respectively. Group comparisons were performed using the Wilcoxon signed-rank test or paired t-test. Consistency was assessed using Kappa statistics, Bland-Altman statistics, intraclass correlation coefficient (ICC) and linear regression.</p><p><strong>Results: </strong>A total of 211 patients were evaluated (median age: 53 years [IQR: 38-63]; range: 10-82 years; 145 men). The mean acquisition time for full free-breathing CMR was 22.6±3.7min. The median image quality scores for cine and LGE images acquired with free-breathing CMR were 4 (IQR: 4-4) and 5 (IQR: 4-5), respectively. Compared with conventional breath-holding CMR, the end-diastolic volume (EDV), end-systolic volume (ESV), EDV index and ESV index measured by free-breathing CMR were slightly higher (all P＜0.05), whereas the left ventricular ejection fraction (LVEF) and left ventricular mass (LVM) were slightly lower (both P＜0.05). Nonetheless, the two methods demonstrated good agreement and correlation (r values: 0.85-0.99). Native T1 and T2 values in healthy subjects from free-breathing CMR were 1214.9±16.7ms and 38.4±3.2ms, respectively. Among the 211 patients, 147 were LGE positive. Except for five patients with image quality scores below 3, all others had scores of 3 or higher.</p><p><strong>Conclusion: </strong>Full free-breathing CMR examinations are feasible and effective in clinical practice, significantly reduce scan time while maintaining high image quality.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101955"},"PeriodicalIF":6.1,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visually assessed ischaemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass.","authors":"Tamim Akbari, Lukas Mach, Daniel J Hammersley, Suzan Hatipoglu, Ruth Owen, Dylan Taylor, Joyce Wong, Shahzad G Raja, Sunil K Bhudia, Dudley J Pennell, Brian P Halliday, Richard E Jones, Sanjay K Prasad","doi":"10.1016/j.jocmr.2025.101953","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101953","url":null,"abstract":"<p><strong>Background: </strong>Serial perfusion cardiovascular magnetic resonance (CMR) in symptomatic patients undergoing coronary artery bypass grafting (CABG) may provide mechanistic insight into dynamic abnormalities of the myocardium.</p><p><strong>Objectives: </strong>To assess how changes in cardiac reperfusion and remodelling associate with symptom improvement in patients undergoing CABG METHODS: Patients awaiting elective CABG completed serial quality of life questionnaires and detailed CMR at baseline and at 6-12 months post CABG as per protocol. Automated fully quantitative stress and rest myocardial blood flow was calculated, alongside assessment of the visual ischaemic burden. Findings were correlated with changes in symptomatology.</p><p><strong>Results: </strong>Of 40 patients who underwent serial evaluation with CMR (mean age 62.1±9.3, median LVEF 68% [IQR: 62-73%]), there was improvement in the median visual ischaemic burden (42% [IQR: 27-51] vs 18% [IQR: 11-21], P<0.001), mean global stress myocardial blood flow (1.34±0.5ml/min/g vs 1.59±0.5ml/min/g, P=0.002) and median global myocardial perfusion reserve (1.85±0.6 vs 2.4±0.9, P<0.001) following CABG. Greater improvement in the SAQ-7 summary score was associated with a greater decrease in the visual ischaemic burden following CABG (ρ=-0.38, P=0.02). Quantitative MBF metrics did not associate with baseline or change in SAQ-7 summary score.</p><p><strong>Conclusion: </strong>Serial perfusion CMR identifies dynamic changes in markers of myocardial perfusion in patients following CABG. Greater reduction of visually assessed ischaemia associated with improvement in SAQ-7 score. Quantitative perfusion indices were not associated with symptom improvement in this study. The results also suggest residual inducible ischaemia post CABG requiring further studies to elucidate its clinical relevance.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101953"},"PeriodicalIF":6.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Blood Flow Quantification in Patients with an Implanted Cardiodefibrillator during Stress and at Rest using a Wideband Perfusion Pulse Sequence: An Initial Feasibility Study.","authors":"Lexiaozi Fan, Maria Davo Jimenez, Dima Bishara, Jacqueline Urban, Kyungpyo Hong, Austin E Culver, Jeremy D Collins, Li-Yueh Hsu, Shuo Wang, Amit R Patel, Oluyemi B Aboyewa, Cagdas Topel, Daniel C Lee, Daniel Kim","doi":"10.1016/j.jocmr.2025.101952","DOIUrl":"10.1016/j.jocmr.2025.101952","url":null,"abstract":"<p><strong>Background: </strong>Although a recently developed wideband perfusion sequence has shown diagnostically acceptable image quality and accurate myocardial blood flow (MBF) quantification at rest in patients with cardiac implanted electronic devices (CIEDs), its performance during vasodilator stress remains unproven. This study aims to determine whether the sequence produces diagnostically acceptable image quality during stress and is capable of quantitatively detecting abnormal stress MBF and myocardial perfusion reserve (MPR) in patients with implanted cardiodefibrillators (ICDs).</p><p><strong>Methods: </strong>We enrolled 29 patients with an ICD (mean age = 63 ± 15 years, 17 males, 12 females) and 11 control patients (mean age = 50 ± 17 years, 6 males, 5 females; negative coronary artery disease; negative stress perfusion CMR; and no cardiac event one year post CMR) with an ICD taped below the left clavicle to mimic image artifacts. Both groups underwent imaging using a six-fold accelerated wideband perfusion sequence during adenosine stress and at rest. Images were reconstructed using a compressed sensing framework. Two clinical readers independently graded the following three categories on a 5-point Likert scale (1: worst, 3: clinically acceptable, 5: best): conspicuity of wall enhancement, noise, and artifact. Pixel-wise stress-rest MBF maps were quantified for both global and segmental analysis. MPR was calculated as the ratio of mean stress to rest MBFs.</p><p><strong>Results: </strong>The median summed visual score was above the acceptable cut-point (>9.0) and not significantly different between the two groups. Both mean global and segmental stress MBF and MPR were significantly lower (p < 0.05) in the ICD patient group (global MBF=1.79±0.50ml/g/min; global MPR=2.11±0.53) compared to the control group (global MBF=2.92±0.52ml/g/min; global MPR=3.28±0.57), while rest MBF showed no significant difference (global MBF=0.88±0.18ml/g/min in the patient group vs. 0.92±0.13ml/g/min in the control group).</p><p><strong>Conclusions: </strong>This study demonstrates the feasibility of using a six-fold accelerated wideband perfusion pulse sequence, which provides diagnostically acceptable image quality during stress and is sensitive for detecting abnormal stress MBF and MPR in patients with ICDs.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101952"},"PeriodicalIF":6.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising Cardiac Diffusion Tensor Imaging In Vivo: More Directions or Repetitions?","authors":"Sam Coveney, David Shelley, Richard Foster, Maryam Afzali, Ana-Maria Poenar, Noor Sharrack, Sven Plein, Erica Dall'Armellina, Jürgen E Schneider, Christopher Nguyen, Irvin Teh","doi":"10.1016/j.jocmr.2025.101951","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101951","url":null,"abstract":"<p><strong>Background: </strong>Cardiac diffusion tensor imaging (cDTI) is sensitive to imaging parameters including the number of unique diffusion encoding directions (ND) and number of repetitions (NR; analogous to number of signal averages or NSA). However, there is no clear guidance for optimising these parameters in the clinical setting.</p><p><strong>Methods: </strong>Spin echo cDTI data with 2^nd order motion compensated diffusion encoding gradients were acquired in ten healthy volunteers on a 3T MRI scanner with different diffusion encoding schemes in pseudo-randomised order. The data were subsampled to yield 96 acquisition schemes with 6 ≤ ND ≤ 30 and 33 ≤ total number of acquisitions (NA_all) ≤ 180. Stratified bootstrapping with robust fitting was performed to assess the accuracy and precision of each acquisition scheme. This was quantified across a mid-ventricular short-axis slice in terms of root mean squared difference (RMSD) with respect to the full reference dataset, and standard deviation (SD) across bootstrap samples respectively.</p><p><strong>Results: </strong>For the same acquisition time, the ND = 30 schemes had on average 48%, 40%, 34% and 34% lower RMSD and 6.2%, 7.4%, 10% and 5.6% lower SD in MD, FA, HA and |E2A| compared to the ND = 6 schemes. Given a fixed number of high b-value acquisitions, there was a trend towards lower RMSD and SD of MD and FA with increasing numbers of low b-value acquisitions. Higher NA_all with longer acquisition times led to improved accuracy in all metrics whereby quadrupling NA_all from 40 to 160 volumes led to a 20%, 39%, 11% and 5.4% reduction in RMSD of MD, FA, HA and |E2A| respectively, averaged across six diffusion encoding schemes. Precision was also improved with a corresponding 53%, 50%, 53% and 36% reduction in SD.</p><p><strong>Conclusions: </strong>We observed that accuracy and precision were enhanced by (i) prioritising number of diffusion encoding directions over number of repetitions given a fixed acquisition time, (ii) acquiring sufficient low b-value data, (iii) using longer protocols where feasible. For clinically relevant protocols, our findings support the use of ND = 30 and NA_b50:NA_b500 ≥ 1/3 for better accuracy and precision in cDTI parameters. These findings are intended to help guide protocol optimisation for harmonisation of cDTI.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101951"},"PeriodicalIF":6.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional 4D Cardiac Magnetic Resonance Strain Predicts Cardiomyopathy Progression in Duchenne Muscular Dystrophy.","authors":"Conner C Earl, Alexa M Jauregui, Marco A Prado, Guang Lin, Kan N Hor, Larry W Markham, Jonathan H Soslow, Craig J Goergen","doi":"10.1016/j.jocmr.2025.101950","DOIUrl":"10.1016/j.jocmr.2025.101950","url":null,"abstract":"<p><strong>Background: </strong>Cardiomyopathy (CMP) is the leading cause of death in Duchenne muscular dystrophy (DMD). Characterization of disease trajectory can be challenging, especially in early stages of CMP where onset and progression may vary. Traditional metrics from cardiovascular magnetic resonance (CMR) imaging such as LVEF (left ventricular ejection fraction) and LGE (late gadolinium enhancement) are often insufficient for assessing the pace of disease progression. We hypothesized that strain patterns from a novel 4D (3D+time) CMR regional strain analysis method can be used to predict DMD CMP progression.</p><p><strong>Methods: </strong>We compiled 190 short-axis cine CMR image stacks for n=66 pediatric DMD patients (13.3 [10.8-16.5] years; median [interquartile range]) imaged for 3 consecutive years and computed regional strain metrics using custom-built feature tracking software. We measured regional strain parameters from the generated 4D endocardial surface mesh.</p><p><strong>Results: </strong>Using LVEF decrease, measured two years following the initial scan, we classified patients into slow (ΔLVEF%<5; n=35) or fast (ΔLVEF%≥5; n=30) progressing groups. There was no statistical difference between the slow and fast-progressing groups in terms of standard metrics such as age, LVEF, or LGE status. However, peak basal circumferential strain (E_cc) and surface area strain (E_a) magnitudes were decreased in fast progressors (p<0.01 for all). Basal E_cc late diastolic strain rate and basal E_a late diastolic strain rate magnitude were also significantly decreased in fast progressors (p<0.01 for all).</p><p><strong>Conclusion: </strong>Regional strain metrics from 4D CMR can be used to differentiate between slow or fast CMP progression in a longitudinal DMD cohort.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101950"},"PeriodicalIF":6.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atorvastatin and Left Atrial Function During Anthracycline-based Chemotherapy.","authors":"Vencel Juhasz, Zsofia D Drobni, Thiago Quinaglia, Hannah K Gilman, Giselle Alexandra Suero-Abreu, Azin Ghamari, Julius C Heemelaar, Donna S Neuberg, Yuchi Han, Bonnie Ky, Raymond Y Kwong, James L Januzzi, Aarti Asnani, Negareh Mousavi, Robert A Redd, Michael Jerosch-Herold, Marielle Scherrer-Crosbie, Tomas G Neilan","doi":"10.1016/j.jocmr.2025.101946","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101946","url":null,"abstract":"<p><strong>Background: </strong>Structural and functional abnormalities of the left atrium (LA) predict adverse outcomes such as heart failure and mortality in many patients with heart disease. However, the effect of anthracyclines on LA structural and functional abnormalities remains incompletely characterized. Further, atorvastatin prevented the anthracycline-associated decline in the left ventricular ejection fraction; however, whether atorvastatin protects against anthracycline-associated impairment of LA structure and function is currently unknown.</p><p><strong>Methods: </strong>In the STOP-CA randomized clinical trial, participants with lymphoma treated with anthracyclines were randomized to placebo (n=150) or atorvastatin (n=150) for 12 months. In post-hoc analyses, CMR-derived LA volumetric and functional measurements (reservoir [GLS], conduit, and booster strain) were measured at baseline and 12 months using feature tracking (FT). The primary endpoint was the difference in the proportion of participants with a ≥1SD decrease in LA GLS between the atorvastatin and placebo groups. The secondary endpoint was a ≥20% relative decrease in LA GLS. Other exploratory endpoints included volume indices and emptying fractions.</p><p><strong>Results: </strong>Of 300 participants, 158 (mean age 51±16 years, 48% female, 83 with atorvastatin) had paired CMR-derived LA strain and volumetric data at baseline and follow-up. Both groups had similar baseline characteristics and cancer treatment. All LA strain and volumetric measures were similar between the two groups at baseline. Among the placebo group, LA GLS decreased from baseline to follow-up (35.5±8.8 vs. 32.4±8.2%, p=0.007). A ≥1SD absolute decrease in LA GLS (8.8% units) was observed among 24% with atorvastatin and 28% with placebo (p=0.59). Similarly, a ≥20% relative decrease in GLS was observed in 25% vs. 31% (p=0.48). Participants over 50 had an almost 10% (9.9%, 95% confidence interval: -18.75, -1.12) greater relative decrease in LA GLS with anthracyclines. There were no differences between cardiac hospitalization rates with a ≥1SD absolute decrease (5% vs. 8%, p=0.72) in LA GLS at 24 months. Among other indices of LA structure and function, the LA total emptying fraction also decreased from baseline to follow-up, with no differences between groups at follow-up.</p><p><strong>Conclusion: </strong>Atorvastatin did not attenuate the decline in CMR-derived LA GLS among lymphoma patients undergoing anthracycline-based chemotherapy.</p><p><strong>Clinical trial registration: </strong>NCT02943590; https://clinicaltrials.gov/study/NCT02943590.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101946"},"PeriodicalIF":6.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of normal reference ranges in cardiac magnetic resonance imaging: The Multi-Ethnic Study of Atherosclerosis.","authors":"Nadine Kawel-Boehm, Spencer L Hansen, Bharath Ambale-Venkatesh, J Jeffrey Carr, J Paul Finn, Michael Jerosch-Herold, Steven M Kawut, Robyn L McClelland, Wendy Post, Martin R Prince, Steven Shea, João A C Lima, David A Bluemke","doi":"10.1016/j.jocmr.2025.101949","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101949","url":null,"abstract":"<p><strong>Background: </strong>Normal reference ranges in cardiovascular imaging studies are typically established as the mean value plus and minus twice the standard deviation (SD) of a healthy reference cohort (\"2 SD-method\"). Although widely used for cardiac magnetic resonance (CMR), this approach has not been previously validated. The purpose of this study was to use longitudinal cohort data to assess the clinical predictive validity of normal reference values for cardiac CMR.</p><p><strong>Methods: </strong>Normal reference ranges for left- and right ventricular (LV and RV) CMR parameters were derived from baseline exam data of 1518 participants (age 45-84 years) in the Multi-Ethnic Study of Atherosclerosis (MESA) study without known CV disease and without established CV risk factors. Cut-off values at 1 and 2 SDs were obtained for the following LV and RV parameters indexed to body surface area: end-diastolic volume (LVEDVi, RVEDVi), end-systolic volume (LVESVi, RVESVi), mass (LVMi, RVMi), as well as for LVED diameter (LVEDD), LVED wall thickness and ejection fraction (LVEF, RVEF). The relationship of reference values to CV events was then evaluated in the entire MESA cohort with CMR data (n=4915), including individuals with CV risk factors at the baseline exam. Cox proportional hazard models were calculated for major adverse and all CV events (MACE and ACE, respectively) at 5 and 10 years of follow-up.</p><p><strong>Results: </strong>At 5 years of follow-up, LVEDVi, LVESVi and LVEF beyond the 2SD-threshold of the mean reference values were predictors of MACE and ACE in men and women (HR 2.1-4.3; P <.001-.029). In men, LVMi and LVED wall thickness above the 1 SD-threshold were associated with CV events (HR 1.6-2.1; P <.001-.002). For women, LVED wall thickness above the 1 SD-threshold significantly increased risk of adverse events (HR 1.6-2.3; P.034-.002) while LVMi was associated with events only for values above the 2SD-threshold (HR 2.7-4.1; P <.001). Notably, LVEDD, RVMi, RVESVi and RVEF were not associated with CV events in men or women. CV events over 10 years showed similar trends.</p><p><strong>Conclusions: </strong>Our results support the clinical relevance of CMR normal reference ranges for LV parameters. Most LV CMR parameters beyond the normal reference range (2SD-threshold) were associated with elevated CV risk at 5 and 10 years. Elevated LVEDDi, RVMi, RVESVi and RVEF however were not associated with CV events.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101949"},"PeriodicalIF":6.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-centre Investigation of Cardiac Diffusion Tensor Imaging in Healthy Volunteers by SCMR Cardiac Diffusion Special Interest Group NETwork (SIGNET).","authors":"Irvin Teh, Kévin Moulin, Pedro F Ferreira, Julie Absil, Maryam Afzali, Peter Agger, Behnaz Akbari, Anthony H Aletras, Satoru Aono, Charles Benton, Suryava Bhattacharya, Pierre Croisille, Yves De Bruecker, Erica Dall'Armellina, Daniel B Ennis, Carl Glessgen, Anna Glinska, Sandra Haltmeier, Ariel Hannum, Erik Hedström, Tawfik Hussein, Sarah Jones, George Joy, Karen Kettless, Won Yong Kim, Sebastian Kozerke, Julie Magat, Raja Muthupillai, Reza Nezafat, Sonia Nielles-Vallespin, John Oshinski, Valéry Ozenne, Dudley J Pennell, Roderick Pettigrew, Iain Pierce, Betty Raman, Agnieszka Sabisz, Jürgen E Schneider, Janet H Sherman, Abhishek Shetye, Rolf Symons, Philippe Thoma, Thomas Treibel, Satonori Tsuneta, Jean-Paul Vallee, Niels Vejlstrup, Magalie Viallon, Christopher Nguyen, Andrew D Scott, Christian T Stoeck","doi":"10.1016/j.jocmr.2025.101948","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101948","url":null,"abstract":"<p><strong>Background: </strong>Cardiac diffusion tensor imaging (cDTI) is an emerging technique for microstructural characterization of the heart and has shown clinical potential in a range of cardiomyopathies. However, there is substantial variation reported for in vivo cDTI results across the literature, and sensitivity of cDTI to differences in imaging sites, scanners, acquisition protocols and post-processing methods remains incompletely understood.</p><p><strong>Methods: </strong>SIGNET is a prospective multi-centre, observational study in travelling and non-travelling healthy volunteers. The study was initiated by the executive board of the SCMR Cardiac Diffusion Special Interest Group (SIG) as a follow up to a previous multi-centre study on phantom validation of cardiac DTI and a recently published SCMR consensus statement on cardiac diffusion MRI. The study has been developed by the Project Management Committee in consultation with the SCMR Cardiac Diffusion SIG, which includes international experts in cardiac diffusion MRI. To date, more than 20 international institutions have engaged with the study, including sites that are new to cardiac DTI, making this the largest collaborative effort in the field.</p><p><strong>Discussion: </strong>SIGNET will provide important information about the key sources of variation in cardiac DTI. This will help rationalise strategies for addressing and minimising such variation. Harmonisation of protocols in this and future studies will underpin efforts to translate cardiac DTI for clinical application.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101948"},"PeriodicalIF":6.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Trajectories of Left Ventricular Myocardial Remodelling: Associations with Cardiovascular Risk Factors in the Multi-Ethnic Study of Atherosclerosis.","authors":"Charlène A Mauger, Bharath Ambale-Venkatesh, Avan Suinesiaputra, David A Bluemke, Colin O Wu, Joao A C Lima, Alistair A Young","doi":"10.1016/j.jocmr.2025.101943","DOIUrl":"https://doi.org/10.1016/j.jocmr.2025.101943","url":null,"abstract":"<p><strong>Background: </strong>Understanding the influence of cardiovascular risk factors on longitudinal cardiac remodelling requires three-dimensional analysis of longitudinal shape changes beyond scalar indicators such as mass and volumes. The aim of this study is to determine trajectories of cardiovascular risk factor-related remodelling in a large cohort imaging study.</p><p><strong>Methods: </strong>We examined 2,521 participants (54% female, aged 60±9y) of the Multi-Ethnic Study of Atherosclerosis (MESA) at baseline and after 10 years. Myocardial remodelling was assessed by longitudinal left ventricular shape trajectories derived from cardiac magnetic resonance imaging using a statistical shape atlas. Penalized logistic regression was used to examine the associations between trajectory scores and cardiovascular risk factors, after adjustment for sex and age at baseline. Multivariate regression was used to determine independent shape changes associated with each risk factor.</p><p><strong>Results: </strong>Between baseline and follow-up, there was a higher prevalence of hypertension (18.4%), antihypertensive medication usage (21.6%), statin usage, and treated diabetes mellitus (8.9%); all p < 0.05. Longitudinal shape trajectory scores had stronger associations with obesity, high blood pressure, hypertension medication and diabetes mellitus, than mass and volume changes (p<0.05). Multivariate regression showed independent longitudinal changes in wall thickening with obesity (13% increase), smoking (11% decrease), and high systolic blood pressure (5.6% increase), with distinct regional variations.</p><p><strong>Conclusions: </strong>Trajectories of cardiovascular risk factor-related longitudinal remodelling can be examined using shape atlases. In addition to global changes, each risk factor is associated with a distinct regional remodelling of the myocardium.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101943"},"PeriodicalIF":6.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}