Journal of Cardiovascular Magnetic Resonance最新文献

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Characterization and Z-score Calculation of Cardiac MRI parameters in patients after the Fontan operation. A Fontan Outcome Registry using CMR Examinations (FORCE) study. 丰坦手术后患者心脏磁共振成像参数的特征和 Z 评分计算。使用CMR检查的丰坦结果登记(FORCE)研究。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-10-21 DOI: 10.1016/j.jocmr.2024.101113
Tarek Alsaied, Runjia Li, Adam Christopher, Mark Fogel, Timothy C Slesnick, Rajesh Krishnamurthy, Vivek Muthurangu, Adam L Dorfman, Christopher Z Lam, Justin Weigand, Jong-Hyeon Jeong, Joshua D Robinson, Laura J Olivieri, Rahul H Rathod
{"title":"Characterization and Z-score Calculation of Cardiac MRI parameters in patients after the Fontan operation. A Fontan Outcome Registry using CMR Examinations (FORCE) study.","authors":"Tarek Alsaied, Runjia Li, Adam Christopher, Mark Fogel, Timothy C Slesnick, Rajesh Krishnamurthy, Vivek Muthurangu, Adam L Dorfman, Christopher Z Lam, Justin Weigand, Jong-Hyeon Jeong, Joshua D Robinson, Laura J Olivieri, Rahul H Rathod","doi":"10.1016/j.jocmr.2024.101113","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101113","url":null,"abstract":"<p><strong>Background: </strong>Cardiac magnetic resonance (CMR) offers valuable hemodynamic insights post-Fontan, but is limited by the absence of normative single ventricle data. The Fontan Outcomes Registry using CMR Examinations (FORCE) is a large international Fontan-specific CMR registry. This study used FORCE registry data to evaluate expected CMR ventricular size/function and create Fontan-specific z-scores adjusting for ventricular morphology (VM) in healthier Fontan patients.</p><p><strong>Methods: </strong>\"Healthier\" Fontan patients were defined as patients free of adverse outcomes, who are New York Heart Association Class I, have mild or less valve disease, and <30% aortopulmonary collateral burden. General linear modeling was performed on 70% of the dataset to create z-scores for volumes and function. Models were tested using the remainder (30%) of the data. The z-scores were compared between children and adults. The z-scores were also compared between \"healthier\" Fontan and patients with adverse outcomes (death, listing for transplantation or multiorgan disease).</p><p><strong>Results: </strong>The \"healthier\" Fontan population included 885 patients (15.0 ± 7.6 years) from 18 institutions with 1,156 CMR examinations. Patients with left ventricle morphology had lower volume, mass and higher ejection fraction (EF) compared to right or mixed (two-ventricles) morphology (p<0.001 for all pairwise comparisons). Gender, BSA and VM were used in z-scores. Of the \"healthier\" Fontan patients, 647 were children <18 years and 238 were adults. Adults had lower ascending aorta flow (2.9 ± 0.7 vs 3.3 ± 0.8L/min/m2, p<0.001) and ascending aorta flow z-scores (-0.16 ± 1.23 vs 0.05 ± 0.95, 0.02) compared to children. Additionally, there were 1595 patients with adverse outcomes who were older (16.1 ± 9.3 vs 15.0 ± 7.6, p<0.001) and less likely to have LV morphology (35 vs 47%, p<0.001). Patients with adverse outcomes had higher z-scores for ventricular volume and mass and lower z-scores for EF and ascending aorta flow compared to the \"healthier\" Fontan cohort.</p><p><strong>Conclusion: </strong>This is the first study to generate CMR z-scores post-Fontan. Importantly the z-scores were generated and tested in \"healthier\" Fontan patients and both pediatric and adult Fontan patients. These equations may improve CMR-based risk stratification after the Fontan operation.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac diffusion-weighted and tensor imaging: a Society for Cardiovascular Magnetic Resonance (SCMR) special interest group consensus statement. 心脏弥散加权和张量成像:心血管磁共振学会(SCMR)特别兴趣小组共识声明。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-10-21 DOI: 10.1016/j.jocmr.2024.101109
E Dall'Armellina, D B Ennis, L Axel, P Croisille, P F Ferreira, A Gotschy, D Lohr, K Moulin, C Nguyen, S Nielles-Vallespin, W Romero, A D Scott, C Stoeck, I Teh, L Tunnicliffe, M Viallon, Wang, A A Young, J E Schneider, D E Sosnovik
{"title":"Cardiac diffusion-weighted and tensor imaging: a Society for Cardiovascular Magnetic Resonance (SCMR) special interest group consensus statement.","authors":"E Dall'Armellina, D B Ennis, L Axel, P Croisille, P F Ferreira, A Gotschy, D Lohr, K Moulin, C Nguyen, S Nielles-Vallespin, W Romero, A D Scott, C Stoeck, I Teh, L Tunnicliffe, M Viallon, Wang, A A Young, J E Schneider, D E Sosnovik","doi":"10.1016/j.jocmr.2024.101109","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101109","url":null,"abstract":"<p><p>Thanks to recent developments in Cardiovascular magnetic resonance (CMR), cardiac diffusion-weighted magnetic resonance is fast emerging in a range of clinical applications. Cardiac diffusion-weighted imaging (cDWI) and diffusion tensor imaging (cDTI) now enable investigators and clinicians to assess and quantify the 3D microstructure of the heart. Free-contrast DWI is uniquely sensitized to the presence and displacement of water molecules within the myocardial tissue, including the intra-cellular, extra-cellular and intra-vascular spaces. CMR can determine changes in microstructure by quantifying: a) mean diffusivity (MD) -measuring the magnitude of diffusion; b) fractional anisotropy (FA) - specifying the directionality of diffusion; c) helix angle (HA) and transverse angle (TA) -indicating the orientation of the cardiomyocytes; d) E2A and E2A mobility - measuring the alignment and systolic-diastolic mobility of the sheetlets, respectively. This document provides recommendations for both clinical and research cDWI and cDTI, based on published evidence when available and expert consensus when not. It introduces the cardiac microstructure focusing on the cardiomyocytes and their role in cardiac physiology and pathophysiology. It highlights methods, observations and recommendations in terminology, acquisition schemes, post-processing pipelines, data analysis and interpretation of the different biomarkers. Despite the ongoing challenges discussed in the document and the need for ongoing technical improvements, it is clear that cDTI is indeed feasible, can be accurately and reproducibly performed and, most importantly, can provide unique insights into myocardial pathophysiology.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial mechanical function measured by cardiac magnetic resonance in patients with heart failure. 通过心脏磁共振测量心力衰竭患者的心肌机械功能。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-10-19 DOI: 10.1016/j.jocmr.2024.101111
Yufan Gao, Boxin Li, Yanhe Ma, Shuo Liang, Anhong Yu, Hong Zhang, Zhigang Guo
{"title":"Myocardial mechanical function measured by cardiac magnetic resonance in patients with heart failure.","authors":"Yufan Gao, Boxin Li, Yanhe Ma, Shuo Liang, Anhong Yu, Hong Zhang, Zhigang Guo","doi":"10.1016/j.jocmr.2024.101111","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101111","url":null,"abstract":"<p><strong>Aim: </strong>Strain analysis offers a valuable tool to assess myocardial mechanics, allowing for the detection of impairments in heart function. This study aims to evaluate the pattern of myocardial strain in patients with heart failure (HF).</p><p><strong>Methods: </strong>In the present study, myocardial strain was measured by cardiac magnetic resonance imaging feature tracking in 35 control subjects without HF and 195 HF patients. The HF patients were further categorized as HF with preserved ejection fraction (HFpEF, n=80), with mid-range ejection fraction (HFmrEF, n=34), and with reduced ejection fraction (HFrEF, n=81). Additionally, quantitative tissue evaluation parameters, including native T1 relaxation time and extracellular volume (ECV), were examined.</p><p><strong>Results: </strong>Compared to controls, patients in all HF groups (HFpEF, HFmrEF, and HFrEF) demonstrated impaired left ventricular (LV) strains and systolic and diastolic strain rates in all three directions (radial, circumferential, and longitudinal) (p < 0.05 for all). LV strains also showed significant correlations with left ventricular ejection fraction and brain natriuretic peptide levels (p < 0.001 for all). Notably, septal contraction was significantly affected in HFpEF compared to controls. While LV torsion was slightly increased in HFpEF, it was decreased in HFrEF. Native T1 relaxation times and ECV fractions were significantly higher in HFrEF compared to HFpEF (p < 0.05). Overall, myocardial strain parameters demonstrated good performance in differentiating HF categories.</p><p><strong>Conclusions: </strong>The myocardial strain impairments exhibit a spectrum of severity in patients with HFpEF, HFmrEF, and HFrEF compared to controls. Assessment of myocardial mechanics using strain analysis may offer a clinically useful tool for monitoring the progression of systolic and diastolic dysfunction in HF patients.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Coronary Microvascular Dysfunction and Exercise Capacity in Dilated Cardiomyopathy. 扩张型心肌病患者冠状动脉微血管功能障碍与运动能力之间的关系
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-10-17 DOI: 10.1016/j.jocmr.2024.101108
Abhishek Dattani, Benjamin A Marrow, Gaurav S Gulsin, Jian L Yeo, Amitha Puranik, Emer M Brady, David Adlam, Anvesha Singh, Mohammedimran M Ansari, Jayanth R Arnold, Hui Xue, Peter Kellman, James S Ware, Gerry P McCann
{"title":"Association Between Coronary Microvascular Dysfunction and Exercise Capacity in Dilated Cardiomyopathy.","authors":"Abhishek Dattani, Benjamin A Marrow, Gaurav S Gulsin, Jian L Yeo, Amitha Puranik, Emer M Brady, David Adlam, Anvesha Singh, Mohammedimran M Ansari, Jayanth R Arnold, Hui Xue, Peter Kellman, James S Ware, Gerry P McCann","doi":"10.1016/j.jocmr.2024.101108","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101108","url":null,"abstract":"<p><strong>Background: </strong>Aerobic exercise capacity is an independent predictor of mortality in dilated cardiomyopathy (DCM), but the central mechanisms contributing to exercise intolerance in DCM are unknown.</p><p><strong>Objectives: </strong>Characterize coronary microvascular function in DCM and determine if cardiovascular magnetic resonance (CMR) measures are associated with aerobic exercise capacity.</p><p><strong>Methods: </strong>Prospective case-control comparison of adults with DCM and matched controls. Adenosine-stress perfusion CMR to assess cardiac structure, function and automated inline myocardial blood flow quantification, and cardiopulmonary exercise testing (CPET) to determine peak VO<sub>2</sub>, were performed. Pre-specified multivariable linear regression, including key clinical and cardiac variables, was undertaken to identify independent associations with peak VO<sub>2</sub>.</p><p><strong>Results: </strong>Sixty-six patients with DCM (mean age 61 years, 71% male) were propensity-matched to 66 controls (mean age 59 years, 71% male) based on age, sex, body mass index and diabetes. DCM patients had markedly lower peak VO<sub>2</sub> (19.8±5.5 versus 25.2±7.3mL/kg/min; P<0.001). The DCM group had greater left ventricular (LV) volumes, lower systolic function, and had more fibrosis compared to controls. In the DCM group, there was similar rest but lower stress myocardial blood flow (1.53±0.49 versus 2.01±0.60mL/g/min; P<0.001) and lower MPR (2.69±0.84 versus 3.15±0.84; P=0.002). Multivariable linear regression demonstrated that LV ejection fraction, extracellular volume fraction and MPR, were independently associated with percentage predicted peak VO<sub>2</sub> in DCM (R<sup>2</sup>=0.531, P<0.001).</p><p><strong>Conclusions: </strong>In comparison to controls, DCM patients have lower stress myocardial blood flow and MPR. In DCM, MPR, LV ejection fraction and fibrosis are independently associated with aerobic exercise capacity.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal changes in systemic right ventricular remodeling in adult patients with transposition of the great vessels as assessed by cardiovascular magnetic resonance imaging. 通过心血管磁共振成像评估大血管转位成人患者全身右心室重塑的纵向变化。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-10-08 DOI: 10.1016/j.jocmr.2024.101107
Jonathan Kochav, Michael P DiLorenzo, Matthew J Lewis, Maarten Groenink, Malou van den Boogaard, Barbara Mulder, Marlon Rosenbaum
{"title":"Longitudinal changes in systemic right ventricular remodeling in adult patients with transposition of the great vessels as assessed by cardiovascular magnetic resonance imaging.","authors":"Jonathan Kochav, Michael P DiLorenzo, Matthew J Lewis, Maarten Groenink, Malou van den Boogaard, Barbara Mulder, Marlon Rosenbaum","doi":"10.1016/j.jocmr.2024.101107","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101107","url":null,"abstract":"<p><strong>Background: </strong>Systemic right ventricular (sRV) physiology occurs in patients with congenitally corrected transposition of the great arteries (ccTGA) and D-TGA post atrial switch repair, and the natural history is of progressive sRV dysfunction. No study has assessed longitudinal changes in sRV remodeling by serial CMR.</p><p><strong>Methods: </strong>Patients evaluated at two adult congenital heart disease centers and who underwent ≥2 CMR exams were studied. Indexed sRV end-diastolic volume (sRVEDVi), end-systolic volume (sRVESVi), and ejection fraction (sRVEF) were determined by a core laboratory. Concurrent echocardiograms were assessed for degree of systemic TR (sTR). Tricuspid valve events were defined as ≥moderate sTR, or interval tricuspid replacement (TVR). Generally, the earliest and most recent studies were compared. A subset of patients were followed with ≥moderate sTR, and then subsequently underwent interval TVR. For these patients, two study time-intervals were defined to analyze the impact of each event independently.</p><p><strong>Results: </strong>67 patients were studied (33±11 years, 47% male, 33% ccTGA), with 72 total time intervals studied (median interval 9.0 years [IQR 4.6-13.3]). There was a small increase in sRVEDVi over time (ΔsRVEDVi 5.5±15.8ml/m<sup>2</sup>, p<0.001), but mean change in sRVEF was not significant (ΔsRVEF 0.1±6.9%, p=0.86); notably, confidence intervals were wide for both. ccTGA patients had a trend towards greater decrement in sRVEF (ΔsRVEF -1.7±6.8 vs 1.3±6.7%, p=0.06). For each 25ml/m2 increase in baseline sRVEDVi, there was a 1.8% decrease in sRVEF (95% CI -3.2% to -0.5%, p=0.01). Patients without significant sTR had lesser deterioration in sRVEF compared to those with ≥moderate sTR or with interval TR intervention (ΔsRVEF 1.8±6.9% vs -2.1±6.6% and -2.6±4.5, p<0.05). Interval sRV conduction delay was associated with a trend towards greater decrements in sRVEF (ΔsRVEF -3.9±6.3 vs. 0.9±6.8%, p=0.07). Overall, underlying congenital anatomy, baseline sRVEDVi, advanced sTR or interval TVR, and sRV conduction delay explained only 16% of the variability in ΔsRVEF over time.</p><p><strong>Conclusions: </strong>Longitudinal changes in sRV remodeling were small, with great heterogeneity. Apparent risk factors in our study, namely underlying congenital anatomy, baseline sRVEDVi, TR events, and sRV conduction disease accounted for only 16% of the variability seen in the longitudinal change of sRVEF.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Active Left Atrial Ejection Fraction as a Non-Invasive Marker in Pulmonary Hypertension Secondary to Heart Failure. 活性左心房射血分数作为继发于心力衰竭的肺动脉高压的非侵入性标记。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-09-25 DOI: 10.1016/j.jocmr.2024.101105
Di Zhou, Xin Li, Jing Xu, Yining Wang, Weichun Wu, Arlene Sirajuddin, Shihua Zhao, Zhihong Liu, Minjie Lu
{"title":"Active Left Atrial Ejection Fraction as a Non-Invasive Marker in Pulmonary Hypertension Secondary to Heart Failure.","authors":"Di Zhou, Xin Li, Jing Xu, Yining Wang, Weichun Wu, Arlene Sirajuddin, Shihua Zhao, Zhihong Liu, Minjie Lu","doi":"10.1016/j.jocmr.2024.101105","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101105","url":null,"abstract":"<p><strong>Background: </strong>Patients with pulmonary hypertension (PH) secondary to left heart failure (HF) exhibit a complex pathophysiological profile and poor prognosis. Left atrial function is pivotal in the progression of this disease, yet its predictive significance remains exclusive. This study aimed to explore the predictive capability of LA metrics in this population and compare them with other common predictors.</p><p><strong>Methods: </strong>In this retrospective study, consecutive patients with PH secondary to HF who underwent cardiac magnetic resonance (CMR) imaging between December 2010 and December 2021 were enrolled. The composite endpoint was defined as all-cause death, heart-lung transplantation, or left ventricular assist device implantation. Survival analyses were performed using Kaplan-Meier curves and Cox regression analyses.</p><p><strong>Results: </strong>A total of 174 patients with PH secondary to HF, with a mean age of 53.2 ± 14.9 years, including 90 men, were included in the final analysis. During a median follow-up of 31.9 months, 58 patients (33.3%) with PH reached the endpoints. There was a fair correlation between active left atrial ejection fraction (LAEF) and pulmonary artery wedge pressure (r = -0.397, p = 0.044). Active LAEF had a strong correlation with oxygen consumption at anaerobic threshold (r = 0.769, p < 0.001) and peak oxygen consumption (r = 0.754, p < 0.001). Active LAEF demonstrated comparable prognostic performance to other variables measured by echocardiography or CMR. After adjusting for clinical variables and left ventricular ejection fraction, active LAEF was still an independent predictor for adverse events (C-statistic: 0.784). Subgroup analysis among HF patients with preserved ejection fraction demonstrated that those with active LAEF ≤ 8.6% had a 7.05-fold higher risk of experiencing the composite endpoint compared to those with active LAEF > 8.6%.</p><p><strong>Conclusion: </strong>Although active LAEF does not demonstrate statistical improvement in outcome discrimination compared to established metrics, it may still merit consideration for assessing disease severity and prognosis in patients with PH secondary to HF. The integration of active LAEF and HF subtypes may stratify individuals at different levels of risk.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Value of Global Coronary Flow Reserve Before and After Elective Percutaneous Coronary Intervention in Patients with Chronic Coronary Syndrome. 慢性冠状动脉综合征患者选择性经皮冠状动脉介入治疗前后全冠状动脉血流储备的预后价值。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-09-25 DOI: 10.1016/j.jocmr.2024.101106
Kai Nogami, Masahiro Hoshino, Eisuke Usui, Yoshihisa Kanaji, Tomoyo Sugiyama, Masahiro Hada, Tatsuhiro Nagamine, Hiroki Ueno, Mirei Setoguchi, Tomohiro Tahara, Tatsuya Sakamoto, Takashi Mineo, Tsunekazu Kakuta
{"title":"Prognostic Value of Global Coronary Flow Reserve Before and After Elective Percutaneous Coronary Intervention in Patients with Chronic Coronary Syndrome.","authors":"Kai Nogami, Masahiro Hoshino, Eisuke Usui, Yoshihisa Kanaji, Tomoyo Sugiyama, Masahiro Hada, Tatsuhiro Nagamine, Hiroki Ueno, Mirei Setoguchi, Tomohiro Tahara, Tatsuya Sakamoto, Takashi Mineo, Tsunekazu Kakuta","doi":"10.1016/j.jocmr.2024.101106","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101106","url":null,"abstract":"<p><strong>Background: </strong>Impaired global coronary flow reserve (G-CFR), evaluated through phase-contrast cine cardiovascular magnetic resonance (PC-CMR), has been linked to worse outcomes in patients with cardiovascular disease. This study aimed to investigate the prognostic value of G-CFR improvement, as evaluated using PC-CMR imaging pre- and post-percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>In this single-center study, 320 patients with chronic coronary syndrome (CCS) who underwent pre- and post-PCI PC-CMR measurements were followed-up to determine major adverse cardiac or cerebrovascular events (MACCE) predictors. MACCE was defined as a composite of cardiac death, nonfatal myocardial infarction, hospitalization due to heart failure, or ischemic stroke. The association between CMR parameters, including baseline data, G-CFR changes post-PCI and MACCE was investigated.</p><p><strong>Results: </strong>G-CFR improvement was observed in 165 (51.6%) patients, while MACCE occurred in 26 (8.1%) during a median follow-up period of 2.5 years. G-CFR improvement was significantly associated with a lower pre-PCI G-CFR. The log-rank test revealed a significant association between patients without G-CFR improvement post-PCI and a poor prognosis. Patients with lower pre-PCI G-CFR and lack of G-CFR improvement exhibited the highest incidence of MACCE. The multivariable Cox proportional hazard model revealed that lack of G-CFR improvement was an independently significant MACCE predictor from pre-PCI G-CFR and SYNTAX score.</p><p><strong>Conclusions: </strong>Besides the association between pre- and post-PCI lower G-CFR and worse prognosis, the presence or absence of G-CFR improvement post-PCI may provide novel insights into the prognosis following elective PCI in patients with CCS.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No differences in native T1 of the renal cortex between Fabry disease patients and healthy subjects in cardiac dedicated native T1 maps. 在心脏专用原生 T1 图中,法布里病患者与健康人的肾皮质原生 T1 无差异。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-09-25 DOI: 10.1016/j.jocmr.2024.101104
Anna Damlin, Felix Kjellberg, Raquel Themudo, Kelvin Chow, Henrik Engblom, Mikael Oscarson, Jannike Nickander
{"title":"No differences in native T1 of the renal cortex between Fabry disease patients and healthy subjects in cardiac dedicated native T1 maps.","authors":"Anna Damlin, Felix Kjellberg, Raquel Themudo, Kelvin Chow, Henrik Engblom, Mikael Oscarson, Jannike Nickander","doi":"10.1016/j.jocmr.2024.101104","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101104","url":null,"abstract":"<p><strong>Background: </strong>Fabry disease (FD) is an X-linked inherited lysosomal storage disease that is caused by deficient activity of the enzyme alpha-galactosidase A. Cardiovascular magnetic resonance (CMR) imaging can detect cardiac sphingolipid accumulation using native T1 mapping. The kidneys are often visible in cardiac CMR native T1 maps, however it is currently unknown if the maps can be used to detect sphingolipid accumulation in the kidneys of FD patients. Therefore, the aim of this study was to evaluate if cardiac dedicated native T1 maps can be used to detect sphingolipid accumulation in the kidneys.</p><p><strong>Methods: </strong>FD patients (n=18, 41 ± 10 years, 44% male) and healthy subjects (n=38, 41 ± 16 years, 47% male) were retrospectively enrolled. Native T1 maps were acquired at 1.5T (MAGNETOM Aera) using MOLLI research sequences. Native T1 values were measured by manually delineating regions of interest (ROI) in the renal cortex, renal medulla, heart, spleen, blood, and liver. Endo- and epicardial borders were delineated in the myocardium and averaged across all slices. Blood ROIs were placed in the left-ventricular blood pool in the midventricular slice.</p><p><strong>Results: </strong>There were no differences in native T1 between the FD patients and the healthy subjects in the renal cortex (1034±88 ms vs 1056±59 ms, p=0.29), blood (1614±111 ms vs 1576 ± 100 ms, p=0.22), spleen (1143±45 ms vs 1132±70 ms, p=0.54) or liver (568±49 ms vs 557±47 ms, p=0.41). Native T1 was lower in the hearts of the FD patients compared to healthy subjects (951±79 vs 1006±38, p<0.01), and higher in the renal medulla (1635±144 vs 1514±81, p<0.01). The results were similar when stratified for sex.</p><p><strong>Conclusion: </strong>Compared to healthy subjects, patients with FD and cardiac involvement had no differences in native T1 of the renal cortex. FD patients had higher native T1 in the renal medulla, which is not totally explained by differences in blood native T1 but may reflect a hyperfiltration state in the development of renal failure. The findings suggest that sphingolipid accumulation in the renal cortex in FD patients could not be detected with cardiac dedicated research native T1 maps.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diffusion Tensor MRI of the Heart: Now Feasible on Your Neighborhood Scanner. 心脏弥散张量 MRI:现在,在您身边的扫描仪上就能实现。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-09-24 DOI: 10.1016/j.jocmr.2024.101101
David E Sosnovik, Daniel B Ennis
{"title":"Diffusion Tensor MRI of the Heart: Now Feasible on Your Neighborhood Scanner.","authors":"David E Sosnovik, Daniel B Ennis","doi":"10.1016/j.jocmr.2024.101101","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101101","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Right ventricular dyssynchrony predicts outcome in pulmonary arterial hypertension when assessed in multiple CMR views. 通过多个 CMR 视图评估右心室不同步情况可预测肺动脉高压的预后。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-09-24 DOI: 10.1016/j.jocmr.2024.101103
Anthony Lindholm, Barbro Kjellström, Göran Rådegran, Håkan Arheden, Ellen Ostenfeld
{"title":"Right ventricular dyssynchrony predicts outcome in pulmonary arterial hypertension when assessed in multiple CMR views.","authors":"Anthony Lindholm, Barbro Kjellström, Göran Rådegran, Håkan Arheden, Ellen Ostenfeld","doi":"10.1016/j.jocmr.2024.101103","DOIUrl":"https://doi.org/10.1016/j.jocmr.2024.101103","url":null,"abstract":"<p><strong>Background: </strong>Right ventricular (RV) dyssynchrony or post systolic contraction (PSC) cause inefficient pumping and have not been investigated as prognostic markers in pulmonary arterial hypertension (PAH).</p><p><strong>Objectives: </strong>To investigate if RV dyssynchrony and PSC are prognostic markers of transplantation-free survival in PAH and if multiple RV views improve the prognostication.</p><p><strong>Methods: </strong>Patients with PAH undergoing cardiac magnetic resonance (CMR) between 2003-2021 were included. For strain analysis, endocardial end-diastolic RV contours were delineated in RV 3-chamber (RV3ch), 4-chamber (4ch) and midventricular short axis slice (SAX). RV dyssynchrony was defined as standard deviation of time to peak strain in the walls from one (4ch), two (4ch and SAX) or three views (4ch, SAX and RV3ch). PSC was defined as peak strain occurring after pulmonary valve closure. Outcome was defined as death or lung transplantation.</p><p><strong>Results: </strong>One hundred-one patients (58±19 years, 66% women) were included. Median follow-up was 37 [51] months. There were 60 events (55 deaths and 5 lung transplantations). Outcome was associated with RV dyssynchrony from three views and with RV strain in 4ch. An increase of RV dyssynchrony - from 3 views - by 1% was associated with a 10% increased risk of lung transplantation or death. There was no association between outcome and RV dyssynchrony in one or two views nor with PSC.</p><p><strong>Conclusion: </strong>Right ventricular dyssynchrony from three views were associated with outcome in PAH, whereas assessing dyssynchrony from one or two views and PSC were not. This implies that assessment of multiple instead of single RV views potentially could be used for prognostication in PAH.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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