Fontan姑息治疗患者的舒张功能障碍与死亡和心脏移植有关。

IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Edward H Hardison, Christopher C Henderson, Rachel K Duncan, Kristen George-Durrett, James C Slaughter, Ryan D Byrne, Joshua D Chew, Benjamin P Frischhertz, David A Parra, Angela J Weingarten, Jonathan H Soslow, Daniel E Clark
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引用次数: 0

摘要

背景:成人丰坦衰竭(FF)有不同的表现,通常诊断较晚。FF的可靠预测因素尚不清楚。舒张功能障碍可能与Fontan姑息治疗后晚期的不良后果有关。方法:将Fontan患者与健康对照组进行比较。FF定义为死亡、移植、诊断为蛋白质丢失性肠病、预测峰值VO2 < 50%或新的利尿剂需求。对短轴平面内的各相进行了等高线化处理,计算了充填和出射曲线。通过心脏磁共振(CMR)测量以下变量:峰值充盈率(PFR)、峰值射血率(PER)、PFR和PER与舒张末期容积(EDV)、至PFR时间(tPFR)和至PER时间(tPER)。结果:与健康对照组(N=96)相比,方丹组(N=98)的舒张功能较差,表现为PFR和PFR/EDV降低,tPFR升高。FF患者(N=39)的心室收缩功能和容积指标与Fontan受试者相似,均无衰竭(NF; N=59)。在以死亡或心脏移植为最严重不良结局的FF患者中,PFR/EDV显著降低,指标总心室质量显著升高。晚期钆增强在FF组的发生率高于NF组。结论:CMR可以识别丰坦人群的舒张功能障碍。与未死亡或未移植的Fontan患者相比,死亡或合并死亡或移植的Fontan循环患者的CMR舒张功能更差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diastolic Dysfunction in Patients with Fontan Palliation is Associated with Death and Heart Transplantation.

Background: Adults with Fontan failure (FF) have variable presentations and are often diagnosed late. Reliable predictors of FF are unknown. Diastolic dysfunction may be associated with adverse outcomes late after Fontan palliation.

Methods: Fontan patients were compared to healthy controls. FF was defined as death, transplant, diagnosis of protein losing enteropathy, peak VO2 < 50% predicted, or new diuretic requirement. All phases in the short axis plane were contoured to calculate filling and ejection curves. The following variables were measured by cardiac magnetic resonance (CMR): peak filling rate (PFR), peak ejection rate (PER), PFR and PER indexed to end diastolic volume (EDV), time to PFR (tPFR), and time to PER (tPER).

Results: Compared to healthy controls (N=96), the Fontan group (N=98) had worse diastolic function as evidenced by decreased PFR and PFR/EDV and increased tPFR. Patients with FF (N=39) had similar ventricular systolic function and volumetrics to the Fontan subjects without failure (NF; N=59). PFR/EDV was significantly reduced and indexed common ventricular mass was significantly higher among FF patients with the most severe adverse outcomes of death or heart transplantation. The prevalence of late gadolinium enhancement was higher in the FF cohort than the NF cohort.

Conclusions: CMR can identify diastolic dysfunction in the Fontan population. Patients with Fontan circulation who died or had a combined outcome of death or transplant had worse diastolic function by CMR compared to Fontan patients without death or transplant.

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来源期刊
CiteScore
10.90
自引率
12.50%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.
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