Journal of Cardiovascular Magnetic Resonance最新文献

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Rest and exercise-stress estimated pulmonary capillary wedge pressure using real-time free-breathing cardiovascular magnetic resonance imaging. 利用实时自由呼吸心血管磁共振成像技术估算静息和运动压力下的肺毛细血管楔压。
IF 6.4 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2024-02-29 DOI: 10.1016/j.jocmr.2024.101032
Sören J Backhaus, Alexander Schulz, Torben Lange, Ruben Evertz, Johannes T Kowallick, Gerd Hasenfuß, Andreas Schuster
{"title":"Rest and exercise-stress estimated pulmonary capillary wedge pressure using real-time free-breathing cardiovascular magnetic resonance imaging.","authors":"Sören J Backhaus, Alexander Schulz, Torben Lange, Ruben Evertz, Johannes T Kowallick, Gerd Hasenfuß, Andreas Schuster","doi":"10.1016/j.jocmr.2024.101032","DOIUrl":"10.1016/j.jocmr.2024.101032","url":null,"abstract":"<p><strong>Background: </strong>Identification of increased pulmonary capillary wedge pressure (PCWP) by right heart catheterization (RHC) is the reference standard for the diagnosis of heart failure with preserved ejection fraction (HFpEF). Recently, cardiovascular magnetic resonance (CMR) imaging estimation of PCWP at rest was introduced as a non-invasive alternative. Since many patients are only identified during physiological exercise-stress, we hypothesized that novel exercise-stress CMR-derived PCWP emerges superior compared to its assessment at rest.</p><p><strong>Methods: </strong>The HFpEF-Stress Trial prospectively recruited 75 patients with exertional dyspnea and diastolic dysfunction who then underwent rest and exercise-stress RHC and CMR. HFpEF was defined according to PCWP (overt HFpEF ≥15 mmHg at rest, masked HFpEF ≥25 mmHg during exercise-stress). CMR-derived PCWP was calculated based on previously published formula using left ventricular mass and either biplane left atrial volume (LAV) or monoplane left atrial area (LAA).</p><p><strong>Results: </strong>LAV (rest/stress: r = 0.50/r = 0.55, p < 0.001) and LAA PCWP (rest/stress: r = 0.50/r = 0.48, p < 0.001) correlated significantly with RHC-derived PCWP while numerically overestimating PCWP at rest and underestimating PCWP during exercise-stress. LAV and LAA PCWP showed good diagnostic accuracy to detect HFpEF (area under the receiver operating characteristic curve (AUC) LAV rest 0.73, stress 0.81; LAA rest 0.72, stress 0.77) with incremental diagnostic value for the detection of masked HFpEF using exercise-stress (AUC LAV rest 0.54 vs stress 0.67, p = 0.019, LAA rest 0.52 vs stress 0.66, p = 0.012). LAV but not LAA PCWP during exercise-stress was a predictor for 24 months hospitalization independent of a medical history for atrial fibrillation (hazard ratio (HR) 1.26, 95% confidence interval 1.02-1.55, p = 0.032).</p><p><strong>Conclusion: </strong>Non-invasive PCWP correlates well with the invasive reference at rest and during exercise stress. There is overall good diagnostic accuracy for HFpEF assessment using CMR-derived estimated PCWP despite deviations in absolute agreement. Non-invasive exercise derived PCWP may particularly facilitate detection of masked HFpEF in the future.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10950869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly efficient free-breathing 3D whole-heart imaging in 3-min: single center study in adults with congenital heart disease. 3 分钟高效自由呼吸三维全心成像:对患有先天性心脏病的成人进行的单中心研究。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2023-12-22 DOI: 10.1016/j.jocmr.2023.100008
Anastasia Fotaki, Kuberan Pushparajah, Christopher Rush, Camila Munoz, Carlos Velasco, Radhouene Neji, Karl P Kunze, René M Botnar, Claudia Prieto
{"title":"Highly efficient free-breathing 3D whole-heart imaging in 3-min: single center study in adults with congenital heart disease.","authors":"Anastasia Fotaki, Kuberan Pushparajah, Christopher Rush, Camila Munoz, Carlos Velasco, Radhouene Neji, Karl P Kunze, René M Botnar, Claudia Prieto","doi":"10.1016/j.jocmr.2023.100008","DOIUrl":"10.1016/j.jocmr.2023.100008","url":null,"abstract":"<p><strong>Background: </strong>Three dimensional, whole-heart (3DWH) MRI is an established non-invasive imaging modality in patients with congenital heart disease (CHD) for the diagnosis of cardiovascular morphology and for clinical decision making. Current techniques utilise diaphragmatic navigation (dNAV) for respiratory motion correction and gating and are frequently limited by long acquisition times. This study proposes and evaluates the diagnostic performance of a respiratory gating-free framework, which considers respiratory image-based navigation (iNAV), and highly accelerated variable density Cartesian sampling in concert with non-rigid motion correction and low-rank patch-based denoising (iNAV-3DWH-PROST). The method is compared to the clinical dNAV-3DWH sequence in adult patients with CHD.</p><p><strong>Methods: </strong>In this prospective single center study, adult patients with CHD who underwent the clinical dNAV-3DWH MRI were also scanned with the iNAV-3DWH-PROST. Diagnostic confidence (4-point Likert scale) and diagnostic accuracy for common cardiovascular lesions was assessed by three readers. Scan times and diagnostic confidence were compared using the Wilcoxon-signed rank test. Co-axial vascular dimensions at three anatomic landmarks were measured, and agreement between the research and the corresponding clinical sequence was assessed with Bland-Altman analysis.</p><p><strong>Results: </strong>The study included 60 participants (mean age ± [SD]: 33 ± 14 years; 36 men). The mean acquisition time of iNAV-3DWH-PROST was significantly lower compared with the conventional clinical sequence (3.1 ± 0.9 min vs 13.9 ± 3.9 min, p < 0.0001). Diagnostic confidence was higher for the iNAV-3DWH-PROST sequence compared with the clinical sequence (3.9 ± 0.2 vs 3.4 ± 0.8, p < 0.001), however there was no significant difference in diagnostic accuracy. Narrow limits of agreement and mean bias less than 0.08 cm were found between the research and the clinical vascular measurements.</p><p><strong>Conclusions: </strong>The iNAV-3DWH-PROST framework provides efficient, high quality and robust 3D whole-heart imaging in significantly shorter scan time compared to the standard clinical sequence.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new era for JCMR. JCMR 的新纪元。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2023-12-26 DOI: 10.1016/j.jocmr.2023.100009
Tim Leiner
{"title":"A new era for JCMR.","authors":"Tim Leiner","doi":"10.1016/j.jocmr.2023.100009","DOIUrl":"10.1016/j.jocmr.2023.100009","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular magnetic resonance imaging and clinical follow-up in patients with clinically suspected myocarditis after COVID-19 vaccination. 接种 COVID-19 疫苗后临床疑似心肌炎患者的心血管磁共振成像和临床随访。
IF 6.4 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2024-03-11 DOI: 10.1016/j.jocmr.2024.101036
Norain Talib, Matteo Fronza, Constantin Arndt Marschner, Paaladinesh Thavendiranathan, Gauri Rani Karur, Kate Hanneman
{"title":"Cardiovascular magnetic resonance imaging and clinical follow-up in patients with clinically suspected myocarditis after COVID-19 vaccination.","authors":"Norain Talib, Matteo Fronza, Constantin Arndt Marschner, Paaladinesh Thavendiranathan, Gauri Rani Karur, Kate Hanneman","doi":"10.1016/j.jocmr.2024.101036","DOIUrl":"10.1016/j.jocmr.2024.101036","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to evaluate cardiovascular magnetic resonance (CMR) findings and their relationship to longer-term clinical outcomes in patients with suspected myocarditis following coronavirus disease 2019 (COVID-19) vaccination.</p><p><strong>Methods: </strong>Consecutive adult patients who underwent clinically indicated CMR for evaluation of suspected myocarditis following messenger ribonucleic acid (mRNA)-based COVID-19 vaccination at a single center between 2021 and 2022 were retrospectively evaluated. Patients were classified based on the revised Lake Louise criteria for T1-based abnormalities (late gadolinium enhancement [LGE] or high T1 values) and T2-based abnormalities (regional T2-hyperintensity or high T2 values).</p><p><strong>Results: </strong>Eighty-nine patients were included (64% [57/89] male, mean age 34 ± 13 years, 38% [32/89] mRNA-1273, and 62% [52/89] BNT162b2). On baseline CMR, 42 (47%) had at least one abnormality; 25 (28%) met both T1- and T2-criteria; 17 (19%) met T1-criteria but not T2-criteria; and 47 (53%) did not meet either. The interval between vaccination and CMR was shorter in those who met T1- and T2-criteria (28 days, IQR 8-69) compared to those who met T1-criteria only (110 days, IQR 66-255, p < 0.001) and those who did not meet either (120 days, interquartile range (IQR) 80-252, p < 0.001). In the subset of 21 patients who met both T1- and T2-criteria at baseline and had follow-up CMR, myocardial edema had resolved and left ventricular ejection fraction had normalized in all at median imaging follow-up of 214 days (IQR 132-304). However, minimal LGE persisted in 10 (48%). At median clinical follow-up of 232 days (IQR 156-405, n = 60), there were no adverse cardiac events. However, mild cardiac symptoms persisted in 7 (12%).</p><p><strong>Conclusion: </strong>In a cohort of patients who underwent clinically indicated CMR for suspected myocarditis following COVID-19 vaccination, 47% had at least one abnormality at baseline CMR. Detection of myocardial edema was associated with the timing of CMR after vaccination. There were no adverse cardiac events. However, minimal LGE persisted in 48% at follow-up.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11004989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fractal analysis: another tool for the toolbox for dilated cardiomyopathy prognostication? 分形分析:DCM 预后工具箱中的又一工具?
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2024-02-02 DOI: 10.1016/j.jocmr.2024.101004
Fiona Chan, Gabriella Captur
{"title":"Fractal analysis: another tool for the toolbox for dilated cardiomyopathy prognostication?","authors":"Fiona Chan, Gabriella Captur","doi":"10.1016/j.jocmr.2024.101004","DOIUrl":"10.1016/j.jocmr.2024.101004","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10944259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitral valve orifice area predicts outcome after biventricular repair in patients with hypoplastic left ventricles. 二尖瓣口面积可预测左心室发育不全患者双心室修复术后的效果
IF 6.4 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2024-02-23 DOI: 10.1016/j.jocmr.2024.101029
David Liddle, Addison Gearhart, Lynn A Sleeper, Minmin Lu, Eric Feins, David N Schidlow, Sunil Ghelani, Andrew J Powell, Sitaram Emani, Rebecca S Beroukhim
{"title":"Mitral valve orifice area predicts outcome after biventricular repair in patients with hypoplastic left ventricles.","authors":"David Liddle, Addison Gearhart, Lynn A Sleeper, Minmin Lu, Eric Feins, David N Schidlow, Sunil Ghelani, Andrew J Powell, Sitaram Emani, Rebecca S Beroukhim","doi":"10.1016/j.jocmr.2024.101029","DOIUrl":"10.1016/j.jocmr.2024.101029","url":null,"abstract":"<p><strong>Background: </strong>Identification of risk factors for biventricular (BiV) repair in children with hypoplastic left ventricles (HLV) has been challenging. We sought to identify preoperative cardiovascular magnetic resonance (CMR) predictors of outcome in patients with HLVs who underwent BiV repair, with a focus on the mitral valve (MV).</p><p><strong>Methods: </strong>Single-center retrospective analysis of preoperative CMRs on patients with HLV (≤50 mL/m<sup>2</sup>) and no endocardial fibroelastosis who underwent BiV repair from 2005-2022. CMR measurements included MV orifice area in diastole. The primary composite outcome included time to death, transplant, BiV takedown, heart failure admission, left atrial decompression, or unexpected reoperation; and the secondary outcome included more than or equal to moderate mitral stenosis and/or regurgitation.</p><p><strong>Results: </strong>Median follow-up was 0.7 (interquartile range 0.1, 2.2) years. Of 122 patients [59 atrioventricular canal (AVC) and 63 non-AVC] age 3 ± 2.8 years at the time of BiV repair, freedom from the primary outcome at 2 years was 53% for AVC and 69% for non-AVC (log rank p = 0.12), and freedom from the secondary outcome at 2 years was 49% for AVC and 79% for non-AVC (log rank p < 0.01). Independent predictors of primary outcome for AVC patients included MV orifice area z-score <-2 and transitional AVC; for non-AVC patients, predictors included MV orifice area z-score <-2, abnormal MV anatomy, and conal-septal ventricular septal defect. Independent predictors of secondary outcome for AVC patients included older age at surgery, transitional AVC, and transposition of the great arteries.</p><p><strong>Conclusion: </strong>In children with HLV, low MV orifice area and pre-existing MV pathology are risk factors for adverse outcome after BiV repair.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diastolic function assessment with four-dimensional flow cardiovascular magnetic resonance using automatic deep learning E/A ratio analysis. 利用自动深度学习 EA 比率分析通过四维血流 CMR 评估舒张功能。
IF 6.4 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2024-03-30 DOI: 10.1016/j.jocmr.2024.101042
Federica Viola, Mariana Bustamante, Ann Bolger, Jan Engvall, Tino Ebbers
{"title":"Diastolic function assessment with four-dimensional flow cardiovascular magnetic resonance using automatic deep learning E/A ratio analysis.","authors":"Federica Viola, Mariana Bustamante, Ann Bolger, Jan Engvall, Tino Ebbers","doi":"10.1016/j.jocmr.2024.101042","DOIUrl":"10.1016/j.jocmr.2024.101042","url":null,"abstract":"<p><strong>Background: </strong>Diastolic left ventricular (LV) dysfunction is a powerful contributor to the symptoms and prognosis of patients with heart failure. In patients with depressed LV systolic function, the E/A ratio, the ratio between the peak early (E) and the peak late (A) transmitral flow velocity, is the first step to defining the grade of diastolic dysfunction. Doppler echocardiography (echo) is the preferred imaging technique for diastolic function assessment, while cardiovascular magnetic resonance (CMR) is less established as a method. Previous four-dimensional (4D) Flow-based studies have looked at the E/A ratio proximal to the mitral valve, requiring manual interaction. In this study, we compare an automated, deep learning-based and two semi-automated approaches for 4D Flow CMR-based E/A ratio assessment to conventional, gold-standard echo-based methods.</p><p><strong>Methods: </strong>Ninety-seven subjects with chronic ischemic heart disease underwent a cardiac echo followed by CMR investigation. 4D Flow-based E/A ratio values were computed using three different approaches; two semi-automated, assessing the E/A ratio by measuring the inflow velocity (MVvel) and the inflow volume (MVflow) at the mitral valve plane, and one fully automated, creating a full LV segmentation using a deep learning-based method with which the E/A ratio could be assessed without constraint to the mitral plane (LVvel).</p><p><strong>Results: </strong>MVvel, MVflow, and LVvel E/A ratios were strongly associated with echocardiographically derived E/A ratio (R<sup>2</sup> = 0.60, 0.58, 0.72). LVvel peak E and A showed moderate association to Echo peak E and A, while MVvel values were weakly associated. MVvel and MVflow EA ratios were very strongly associated with LVvel (R<sup>2</sup> = 0.84, 0.86). MVvel peak E was moderately associated with LVvel, while peak A showed a strong association (R<sup>2</sup> = 0.26, 0.57).</p><p><strong>Conclusion: </strong>Peak E, peak A, and E/A ratio are integral to the assessment of diastolic dysfunction and may expand the utility of CMR studies in patients with cardiovascular disease. While underestimation of absolute peak E and A velocities was noted, the E/A ratio measured with all three 4D Flow methods was strongly associated with the gold standard Doppler echocardiography. The automatic, deep learning-based method performed best, with the most favorable runtime of ∼40 seconds. As both semi-automatic methods associated very strongly to LVvel, they could be employed as an alternative for estimation of E/A ratio.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of dysglycaemia with persistent infarct core iron in patients with acute ST-segment elevation myocardial infarction. 急性 ST 段抬高型心肌梗死患者血糖异常与梗死核心铁持续存在的关系
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2024-01-17 DOI: 10.1016/j.jocmr.2024.100996
Ivan Lechner, Martin Reindl, Fritz Oberhollenzer, Christina Tiller, Magdalena Holzknecht, Priscilla Fink, Thomas Kremser, Paolo Bonatti, Felix Troger, Benjamin Henninger, Agnes Mayr, Axel Bauer, Bernhard Metzler, Sebastian J Reinstadler
{"title":"Association of dysglycaemia with persistent infarct core iron in patients with acute ST-segment elevation myocardial infarction.","authors":"Ivan Lechner, Martin Reindl, Fritz Oberhollenzer, Christina Tiller, Magdalena Holzknecht, Priscilla Fink, Thomas Kremser, Paolo Bonatti, Felix Troger, Benjamin Henninger, Agnes Mayr, Axel Bauer, Bernhard Metzler, Sebastian J Reinstadler","doi":"10.1016/j.jocmr.2024.100996","DOIUrl":"10.1016/j.jocmr.2024.100996","url":null,"abstract":"<p><strong>Background: </strong>Dysglycaemia increases the risk of myocardial infarction and subsequent recurrent cardiovascular events. However, the role of dysglycaemia in ischemia/reperfusion injury with development of irreversible myocardial tissue alterations remains poorly understood. In this study we aimed to investigate the association of ongoing dysglycaemia with persistence of infarct core iron and their longitudinal changes over time in patients undergoing primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI).</p><p><strong>Methods: </strong>We analyzed 348 STEMI patients treated with primary PCI between 2016 and 2021 that were included in the prospective MARINA-STEMI study (NCT04113356). Peripheral venous blood samples for glucose and glycated hemoglobin (HbA1c) measurements were drawn on admission and 4 months after STEMI. Cardiac magnetic resonance (CMR) imaging including T2 * mapping for infarct core iron assessment was performed at both time points. Associations of dysglycaemia with persistent infarct core iron and iron resolution at 4 months were calculated using multivariable regression analysis.</p><p><strong>Results: </strong>Intramyocardial hemorrhage was observed in 147 (42%) patients at baseline. Of these, 89 (61%) had persistent infarct core iron 4 months after infarction with increasing rates across HbA1c levels (<5.7%: 33%, ≥5.7: 79%). Persistent infarct core iron was independently associated with ongoing dysglycaemia defined by HbA1c at 4 months (OR: 7.87 [95% CI: 2.60-23.78]; p < 0.001), after adjustment for patient characteristics and CMR parameters. The independent association was present even after exclusion of patients with diabetes (pre- and newly diagnosed, n = 16).</p><p><strong>Conclusions: </strong>In STEMI patients treated with primary PCI, ongoing dysglycaemia defined by HbA1c is independently associated with persistent infarct core iron and a lower likelihood of iron resolution. These findings suggest a potential association between ongoing dysglycaemia and persistent infarct core iron, which warrants further investigation for therapeutic implications.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular magnetic resonance reference values of right ventricular volumetric variables in patients with hypoplastic left heart syndrome. 左心发育不全综合征患者右心室容积变量的 CMR 参考值。
IF 4.2 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2024-03-16 DOI: 10.1016/j.jocmr.2024.101038
Andrik Ballenberger, Amke Caliebe, Sylvia Krupickova, Anselm Uebing, Dominik Daniel Gabbert, Inga Voges
{"title":"Cardiovascular magnetic resonance reference values of right ventricular volumetric variables in patients with hypoplastic left heart syndrome.","authors":"Andrik Ballenberger, Amke Caliebe, Sylvia Krupickova, Anselm Uebing, Dominik Daniel Gabbert, Inga Voges","doi":"10.1016/j.jocmr.2024.101038","DOIUrl":"10.1016/j.jocmr.2024.101038","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular magnetic resonance (CMR) has established itself as the gold standard for serial assessment of systemic right ventricular (RV) performance but due to the lack of standardized RV reference values for hypoplastic left heart syndrome (HLHS) patients, the interpretation of RV volumetric data in HLHS remains difficult. Therefore, this study aimed to close this gap by providing CMR reference values for the systemic RV in HLHS patients.</p><p><strong>Methods: </strong>CMR scans of 160 children, adolescents, and young adults (age range 2.2-25.2 years, 106 males) with HLHS were retrospectively evaluated. All patients were studied following total cavopulmonary connection. Short-axis stacks were used to measure RV end-diastolic and end-systolic volumes (RVEDV, RVESV), RV stroke volume (RVSV), RV ejection fraction (RVEF), and RV end-diastolic myocardial mass (RVEDMM). Univariable and multiple linear regression analyses were performed to assess associations between RV parameters and demographic and anthropometric characteristics. Following the results of the regression analysis, reference graphs and tables were created with the Lambda-Mu-Sigma method.</p><p><strong>Results: </strong>Multiple linear regression analysis showed strong associations between body height and RVEDV, RVESV as well as RVSV. Age was highly associated with RVEDMM. Therefore, percentile curves and tables were created with respect to body height (RVEDV, RVESV, RVSV) and age (RVEDMM). The influence of demographic and anthropometric parameters on RVEF was mild, thus no percentile curves and tables for RVEF are provided.</p><p><strong>Conclusion: </strong>We were able to define CMR reference values for RV volumetric variables for HLHS patients. These data might be useful for the assessment and interpretation of CMR scans in these patients and for research in this field.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of 12-lead electrocardiogram at 0.55T for improved cardiac monitoring in magnetic resonance imaging. 评估 0.55T 磁共振成像中的 12 导联心电图,以改进磁共振成像心脏监测。
IF 6.4 1区 医学
Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-06-01 Epub Date: 2024-02-10 DOI: 10.1016/j.jocmr.2024.101009
Aravindan Kolandaivelu, Christopher G Bruce, Felicia Seemann, Dursun Korel Yildirim, Adrienne E Campbell-Washburn, Robert J Lederman, Daniel A Herzka
{"title":"Evaluation of 12-lead electrocardiogram at 0.55T for improved cardiac monitoring in magnetic resonance imaging.","authors":"Aravindan Kolandaivelu, Christopher G Bruce, Felicia Seemann, Dursun Korel Yildirim, Adrienne E Campbell-Washburn, Robert J Lederman, Daniel A Herzka","doi":"10.1016/j.jocmr.2024.101009","DOIUrl":"10.1016/j.jocmr.2024.101009","url":null,"abstract":"<p><strong>Background: </strong>The 12-lead electrocardiogram (ECG) is a standard diagnostic tool for monitoring cardiac ischemia and heart rhythm during cardiac interventional procedures and stress testing. These procedures can benefit from magnetic resonance imaging (MRI) information; however, the MRI scanner magnetic field leads to ECG distortion that limits ECG interpretation. This study evaluated the potential for improved ECG interpretation in a \"low field\" 0.55T MRI scanner.</p><p><strong>Methods: </strong>The 12-lead ECGs were recorded inside 0.55T, 1.5T, and 3T MRI scanners, as well as at scanner table \"home\" position in the fringe field and outside the scanner room (seven pigs). To assess interpretation of ischemic ECG changes in a 0.55T MRI scanner, ECGs were recorded before and after coronary artery occlusion (seven pigs). ECGs was also recorded for five healthy human volunteers in the 0.55T scanner. ECG error and variation were assessed over 2-minute recordings for ECG features relevant to clinical interpretation: the PR interval, QRS interval, J point, and ST segment.</p><p><strong>Results: </strong>ECG error was lower at 0.55T compared to higher field scanners. Only at 0.55T table home position, did the error approach the guideline recommended 0.025 mV ceiling for ECG distortion (median 0.03 mV). At scanner isocenter, only in the 0.55T scanner did J point error fall within the 0.1 mV threshold for detecting myocardial ischemia (median 0.03 mV in pigs and 0.06 mV in healthy volunteers). Correlation of J point deviation inside versus outside the 0.55T scanner following coronary artery occlusion was excellent at scanner table home position (r<sup>2</sup> = 0.97), and strong at scanner isocenter (r<sup>2</sup> = 0.92).</p><p><strong>Conclusion: </strong>ECG distortion is improved in 0.55T compared to 1.5T and 3T MRI scanners. At scanner home position, ECG distortion at 0.55T is low enough that clinical interpretation appears feasible without need for more cumbersome patient repositioning. At 0.55T scanner isocenter, ST segment changes during coronary artery occlusion appear detectable but distortion is enough to obscure subtle ST segment changes that could be clinically relevant. Reduced ECG distortion in 0.55T scanners may simplify the problem of suppressing residual distortion by ECG cable positioning, averaging, and filtering and could reduce current restrictions on ECG monitoring during interventional MRI procedures.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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