Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Synthetic extracellular volume fraction as an imaging biomarker of the myocardial interstitium without blood sampling: a systematic review and meta-analysis.","authors":"Naofumi Yasuda, Shingo Kato, Nobuyuki Horita, Ryusuke Sekii, Shungo Sawamura, Hiroaki Nagase, Daisuke Utsunomiya","doi":"10.1016/j.jocmr.2025.101889","DOIUrl":"10.1016/j.jocmr.2025.101889","url":null,"abstract":"<p><strong>Background: </strong>The calculation of conventional extracellular volume fraction (ECV) requires blood hematocrit (Hct) measurement. Based on the relationship between Hct and blood T1 relaxivity for cardiac magnetic resonance (CMR), a synthetic ECV could be estimated without a blood sampling. The aim of this study was to evaluate the correlation and agreement in the quantification of synthetic ECV and laboratory ECV from conventional Hct measurements.</p><p><strong>Methods: </strong>Electronic database searches of PubMed, Web of Science Core Collection, Cochrane advanced search, and EMBASE were performed. The authors employed a meta-analysis using the generic inverse variance method with a random-effects model to estimate the summary correlation coefficient and mean absolute difference between synthetic and laboratory ECV.</p><p><strong>Results: </strong>Of 38 papers, 10 studies comprising 4492 patients were identified. Overall, there was an excellent correlation between synthetic ECV and laboratory ECV (0.95 [95% confidence interval (CI): 0.92 to 0.97]) at 1.5T CMR and (0.91 [95% CI: 0.86 to 0.94]) at 3.0T CMR. The pooled mean difference between synthetic ECV and laboratory ECV was 0.61% (95% CI: 0.23 to 0.98%, I² = 0%, p for heterogeneity = 0.67) at 1.5T CMR and 0.24% (95% CI: -0.13 to 0.61%, I² = 19%, p for heterogeneity = 0.25) at 3.0T CMR.</p><p><strong>Conclusion: </strong>This study is the first comprehensive systematic review and meta-analysis of synthetic ECV evaluation at CMR. Synthetic ECV demonstrated an excellent correlation with laboratory ECV, with a mean difference of less than 1%, and offers noninvasive and instantaneous quantification of the myocardial extracellular space without the need for blood sampling.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101889"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic failure mode evaluation using non-linear phase contrast correction to improve flow measurement accuracy in cardiovascular magnetic resonance phase contrast imaging.","authors":"Ana Beatriz Solana, Savine C S Minderhoud, Piotr A Wielopolski, Juan Antonio Hernandez-Tamames, Ricardo P J Budde, Willem A Helbing, Martin A Janich, Alexander Hirsch","doi":"10.1016/j.jocmr.2025.101895","DOIUrl":"10.1016/j.jocmr.2025.101895","url":null,"abstract":"<p><strong>Background: </strong>Phase contrast (PC) cardiovascular magnetic resonance (CMR) is clinically used to quantify flow. The quantification accuracy is diminished by background phase errors. Image-based background phase correction algorithms are commercially available, but their accuracy is still under evaluation. Here, we validate a recently developed non-linear phase contrast correction (nPCcor) algorithm that includes automatic failure mode classification in a large single-vendor multi-scanner retrospective study.</p><p><strong>Methods: </strong>Three hundred forty-six through-plane PC images at the aortic valve (AAo) and pulmonary artery (PA) were acquired on three different GE HealthCare 1.5T clinical MRI scanners. Each PC scan was repeated on a static phantom, and the static phantom-corrected PC series was considered as the reference standard. Two image-based static tissue background phase corrections were applied on each PC series: a linear and the nPCcor. Accuracy of nPCcor was studied by comparing the net flow in the vessel of interest for the uncorrected, linear-corrected, and nPCcor images with respect to the static phantom-corrected series. Accuracy was defined as a difference in net flow ≤10% with respect to the static phantom corrected net flow.</p><p><strong>Results: </strong>Flow measurements using the nPCcor images after nPCcor automatic classification were found to be accurate for 87% (281/323) of PC datasets, 6% and 17% better than using uncorrected and linear-corrected (p<0.05), respectively. Most importantly, nPCcor was able to correctly identify 70% (16/23) PC cases likely to provide inaccurate flow measurements. Flow measurements after nPCcor in the scanner with the largest phase offsets were found to be accurate for 74% (62/84) of PC datasets, 22% better than using the uncorrected images (p<0.05). nPCcor correction was statistically significant more accurate than linear correction for all scanners (p<0.05). The percentage of regurgitation reclassification of ≥1 category decreased to 8% (8/323) after nPCcor correction, 3% better than for uncorrected images.</p><p><strong>Conclusion: </strong>nPCcor with automatic failure mode evaluation improved accuracy with respect to no correction and linear correction and successfully identified PC scans that are likely to result in unreliable flow measurements. nPCcor performance and phase offset errors varied greatly among scanners using the same CMR protocol. nPCcor has higher impact in scanners exhibiting the largest background phase offsets.</p><p><strong>Trial registration: </strong>observational study.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101895"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doppler ultrasound gating for adult cardiovascular magnetic resonance: Initial experience.","authors":"Lucia D Beissel, Fabian Kording, Christian Ruprecht, Alexander Isaak, Thomas M Vollbrecht, Claus C Pieper, Daniel Kuetting, Abdulamir Ali, Pia Wölfl, Christopher Hart, Julian A Luetkens","doi":"10.1016/j.jocmr.2025.101862","DOIUrl":"10.1016/j.jocmr.2025.101862","url":null,"abstract":"<p><strong>Background: </strong>Despite being a common gating method for cardiovascular magnetic resonance (CMR), electrocardiogram (ECG) gating has its disadvantages, and new gating strategies are desirable. An alternative CMR gating method is Doppler ultrasound (DUS) gating, which detects blood flow and ventricular movement. The aim of this study was to prove the feasibility of DUS gating as a novel CMR gating method in a clinical patient population.</p><p><strong>Methods: </strong>In this prospective study, patients underwent clinically indicated CMR. Balanced steady-state free precession two-dimensional cine sequences in short-axis and 4-chamber views were acquired using ECG and DUS gating. DUS and ECG signal were recorded simultaneously. Time difference between R-wave and DUS systolic trigger detection was defined as trigger delay, the standard deviation of trigger delays as trigger jitter. Left and right ventricular parameters were assessed: left and right ventricular ejection fraction (LVEF, RVEF) and left and right ventricular end-diastolic volume index (LVEDVI, RVEDVI). Overall image quality was assessed using a 5-point Likert scale (5 = excellent to 1 = non-diagnostic). For statistical analysis, paired t-test, Wilcoxon test, Pearson correlation, and intraclass correlation coefficient (ICC) were employed.</p><p><strong>Results: </strong>Twenty-one patients (7 female) were included (age: 45.4 ± 19.7 years; body mass index: 27.6 ± 5.5 kg/m²). DUS mean trigger delay was 128 ± 28 ms. DUS mean trigger jitter was 23 ± 13 ms. Overall image quality showed no difference between ECG and DUS gating (e.g., short axis: 5 [interquartile range (IQR) 3-5] vs 4 [IQR 3.5-5]; P = 0.21). Quantitative analysis revealed no differences between ECG and DUS gating: LVEF (53.2 ± 9.2% vs 52.3 ± 9.1%; P = 0.18; ICC 0.97 [95% confidence interval [CI] 0.93-0.99]), LVEDVI (84.5 ± 15.8 mL/m² vs 83.3 ± 15.8 mL/m²; P = 0.06; ICC 0.99 [95% CI 0.98-1.00]), RVEF (52.8 ± 8.0% vs 51.6 ± 7.2%; P = 0.06; ICC 0.96 [95% CI 0.89-0.99]), and RVEDVI (80.8 ± 17.6 mL/m² vs 80.9 ± 16.5 mL/m²; P = 0.91; ICC 0.98 [95% CI 0.96-0.99]). In one patient with a prominent lingula of the lung image quality was non-diagnostic with DUS gating.</p><p><strong>Conclusion: </strong>CMR gating with DUS is feasible and can offer an equivalent performance to ECG regarding image quality and quantitative parameter assessment.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101862"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coprime dual-velocity encoding for extended velocity dynamic range in 4D flow magnetic resonance imaging.","authors":"Marta Beghella Bartoli, Sara Boccalini, David Chechin, Loic Boussel, Philippe Douek, Damien Garcia, Monica Sigovan","doi":"10.1016/j.jocmr.2025.101871","DOIUrl":"10.1016/j.jocmr.2025.101871","url":null,"abstract":"<p><strong>Background: </strong>In the field of cardiovascular imaging, four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) provides non-invasive assessment of blood flow. Dual velocity encoding (dual-VENC) strategies have emerged to obtain quantitative information on both low and high blood flow velocities simultaneously. However, these strategies often encounter difficulties in coping with large velocity ranges. This work presents a dual-VENC 4D flow CMR sequence that utilizes the coprime rule to define the VENC ratio.</p><p><strong>Methods: </strong>A dual-VENC 4D flow CMR sequence and reconstruction algorithm were developed and validated in vitro at two different field strengths, using a flow phantom generating realistic complex flow patterns. A digital twin of the phantom allowed comparison of the MRI measurements with computational fluid dynamics (CFD) simulations. Three patients with different cardiac pathologies were scanned in order to evaluate the in vivo feasibility of the proposed method.</p><p><strong>Results: </strong>The results of the in vitro acquisitions demonstrated significant improvement in velocity-to-noise ratio (VNR) with respect to single-VENC acquisitions (110±3%) and conventional dual-VENC de-aliasing approach (75±3%). Furthermore, the effectiveness of aliasing correction was demonstrated even when both sets of images from the dual-VENC acquisition presented velocity aliasing artifacts. We observed a high degree of agreement between the measured and simulated velocity fields.</p><p><strong>Conclusion: </strong>The strength of this approach lies in the fact that, unlike the conventional de-aliasing method, no data is discarded. The final image is obtained by a weighted average of the VENC_low and VENC_high datasets. Consequently, setting the value of the VENC_high to prevent aliasing is no longer necessary, and higher VNR gains are possible.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101871"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic handgrip exercise for the detection of myocardial ischemia using fast Strain-ENCoded cardiovascular magnetic resonance.","authors":"Andreas Ochs, Michael Nippes, Janek Salatzki, Lukas D Weberling, Nael Osman, Johannes Riffel, Hugo A Katus, Matthias G Friedrich, Norbert Frey, Marco M Ochs, Florian André","doi":"10.1016/j.jocmr.2025.101879","DOIUrl":"10.1016/j.jocmr.2025.101879","url":null,"abstract":"<p><strong>Background: </strong>Previous data suggest dynamic handgrip exercise (DHE) as a potential physiological, needle-free stressor feasible for cardiovascular magnetic resonance (CMR) examinations. DHE-fast Strain-ENCoded imaging (fSENC) is potentially cost-saving, ultra-fast and avoids pharmacological side effects thereby targeting the drawbacks of conventional pharmacological stress CMR.</p><p><strong>Objectives: </strong>To assess the diagnostic accuracy of DHE-fSENC for detecting ischemia-related wall motion abnormalities in suspected obstructive coronary artery disease (CAD).</p><p><strong>Methods: </strong>Patients with known or suspected obstructive CAD referred for CMR stress testing were prospectively enrolled. Diagnostic accuracy was assessed in comparison to pharmacological stress CMR and in a subgroup, compared to invasive coronary angiography (ICA). The CMR protocol was extended by both-handed DHE with 80 repetitions per minute over 2 min followed by fSENC short-axis acquisition before pharmacological stress testing. Stress-induced impairment of regional longitudinal strain was graded suspicious for obstructive CAD.</p><p><strong>Results: </strong>Two-hundred sixty individuals with cardiovascular high-risk profile (64±13years, 75% male) were enrolled. DHE-fSENC provided a sensitivity of 79% (95% CI: 64-89) and specificity of 87% (95% CI 82-91) compared to pharmacological stress CMR. In a subgroup of 105 patients with recent ICA, high diagnostic accuracy was found for the detection of obstructive CAD (sensitivity 82% [95% CI: 67-92], specificity 89% [95% CI: 78-95]). Exam duration of DHE-fSENC was significantly reduced compared to conventional CMR stress protocols (DHE-fSENC 207±69 s vs. adenosine-perfusion 287±82 s vs. dobutamine-cine 1132±294 s, all p<0.001).</p><p><strong>Conclusion: </strong>DHE-fSENC allows for a reliable and fast detection of obstructive CAD, thereby expanding the applicability of needle-free CMR stress testing.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101879"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmental redistribution of myocardial blood flow after coronary sinus reducer implantation demonstrated by quantitative perfusion cardiovascular magnetic resonance.","authors":"Kevin Cheng, Francisco Alpendurada, Chiara Bucciarelli-Ducci, Jose Almeida, Peter Kellman, Jonathan M Hill, Dudley J Pennell, Ranil de Silva","doi":"10.1016/j.jocmr.2025.101868","DOIUrl":"10.1016/j.jocmr.2025.101868","url":null,"abstract":"<p><strong>Background: </strong>The coronary sinus reducer (CSR) is a novel percutaneous treatment for patients with refractory angina. Increasing evidence supports its clinical efficacy in patients with advanced epicardial coronary artery disease. However, its mechanism of action and its effects on myocardial perfusion remain undefined. Using quantitative stress perfusion cardiovascular magnetic resonance (CMR), this study assessed changes in myocardial perfusion in patients with refractory angina undergoing CSR implantation.</p><p><strong>Methods: </strong>This single-center retrospective observational cohort study included 16 patients. Rest and adenosine stress perfusion CMR was performed before and at median 5 months after CSR implantation. Perfusion images were acquired using a dual-sequence quantitative protocol with automated generation of myocardial blood flow (MBF; mL/min/g). In addition to visual assessment of ischemic segments, changes in absolute MBF across myocardial segments and between myocardial layers were analyzed.</p><p><strong>Results: </strong>A high proportion of myocardial segments had visually adjudicated ischemia at baseline (208 out of 254: 81.9%), which significantly reduced after CSR implantation (175 out of 254: 68.9%; P = 0.001). There were no changes in global MBF or strain values. Changes in myocardial perfusion reserve (MPR) correlated with baseline MPR with more ischemic segments at baseline improving to a greater extent at follow-up. Similar patterns were observed in both the left and right coronary artery territories. Changes in endocardial/epicardial MBF ratio at stress were similarly dependent on baseline values.</p><p><strong>Conclusion: </strong>In patients with refractory angina undergoing CSR implantation, quantitative stress perfusion CMR demonstrated redistribution of myocardial perfusion across segments, from less ischemic to more ischemic myocardium, and across myocardial layers with greatest improvements in endocardial perfusion observed in the most ischemic myocardium. Further studies are needed to validate the different patterns of MBF redistribution that may occur after CSR implantation and correlate with clinical outcomes.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101868"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing image quality in fetal cardiovascular magnetic resonance cine imaging using Doppler ultrasound gating: A multicenter study.","authors":"Thomas M Vollbrecht, Luis F Goncalves, Dianna M E Bardo, Christopher Hart, Heide Boeth, Alex J Barker, Richard M Friesen, Julian A Luetkens","doi":"10.1016/j.jocmr.2025.101875","DOIUrl":"10.1016/j.jocmr.2025.101875","url":null,"abstract":"<p><strong>Background: </strong>Fetal cine cardiovascularmagnetic resonance (CMR) is an emerging technique for evaluating the fetal heart in conditions such as congenital heart disease, but limited evidence on factors affecting image quality restricts its clinical potential. This study investigated key determinants of image quality in a multicenter cohort.</p><p><strong>Methods: </strong>This study analyzed fetal CMR scans from April 2021 to July 2023 at three centers (University Hospital Bonn, Children's Hospital Colorado, Phoenix Children's Hospital). Cine image quality was assessed using a 5-point Likert scale (1=non-diagnostic to 5=excellent) across three criteria as follows: contour sharpness, blood-to-structure contrast, and artifacts. Overall image quality scores were calculated by the average of all criteria. Apparent signal-to-noise (aSNR) and contrast-to-noise ratios (aCNR) were measured. Nine parameters were evaluated for their impact on image quality, namely: gestational age, body mass index (BMI), fetal motion, patient positioning, gating signal stability, breathing technique, field strength, slice thickness, and flip angle. Comparisons were conducted using the Mann-Whitney U test.</p><p><strong>Results: </strong>A total of 98 scans were analyzed. Higher overall image quality, aSNR, and aCNR were observed in participants with BMI <30 kg/m², gestational age ≥32 weeks, low fetal motion severity, and stable gating signals (e.g., overall image quality for BMI <30 kg/m² vs ≥30 kg/m²: 4.4±0.7 vs. 4.1±0.7, p<0.001). Supine positioning resulted in better overall image quality compared to the left lateral position (4.5±0.5 vs. 4.2±0.8, p=0.001). Breath-holds provided similar overall image quality but improved contour sharpness and reduced artifacts compared to free breathing (5 [4,5] vs. 4 [4,5], p=0.042; and 4 [3-5] vs. 4 [3-5], p=0.014, respectively). At 1.5T field strength, higher contrast and fewer artifacts were observed compared to 3T (5 [4,5] vs. 5 [4,5], p=0.041; and 4 [4,5] vs. 4 [3-5], p=0.010, respectively). Slice thickness showed no significant impact on image quality.</p><p><strong>Conclusion: </strong>Various factors (e.g. BMI) influence fetal cardiac cine MRI image quality. Understanding these factors may help achieving reliable examinations and better exploit the potential of fetal cardiac MRI in clinical routine.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101875"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid slice-to-volume four-dimensional flow in pediatric congenital heart disease: a feasibility study.","authors":"Valérie Béland, Datta Singh Goolaub, Sharon Portnoy, Shi-Joon Yoo, Christopher Z Lam, Christopher K Macgowan","doi":"10.1016/j.jocmr.2025.101887","DOIUrl":"10.1016/j.jocmr.2025.101887","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular magnetic resonance (CMR) allows cardiac hemodynamic assessment in patients with congenital heart disease (CHD). However, conventional techniques are time-consuming and may require blood contrast agents. Slice-to-volume reconstruction (SVR) four-dimensional (4D) flow is an innovative imaging technique that may overcome these limitations. This study aimed to assess the feasibility of SVR 4D flow in pediatric CHD.</p><p><strong>Methods: </strong>Patients with CHD (n=7, age=12.9±2.8years) underwent CMR with conventional two-dimensional (2D) phase-contrast magnetic resonance imaging (2D PCMRI) and SVR 4D flow. SVR 4D flow datasets were reconstructed from multi-slice 2D spiral PCMRI acquisitions, which were combined via slice-to-volume reconstruction. Mean flows in major thoracic vessels were measured and compared between the two techniques. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated for each participant and compared between imaging techniques.</p><p><strong>Results: </strong>Linear regression for SVR 4D flow against 2D PCMRI showed good agreement for mean flows (slope=1.03, intercept=-5.31 mL/s, r²=0.95). The SNR and CNR did not differ significantly between 2D PCMRI and SVR 4D flow data (SNR: p=0.85, CNR: p=0.90).</p><p><strong>Conclusion: </strong>Our results suggest that SVR 4D flow CMR is a feasible 5-minute scan (relative to multiple 2D PCMRI prescriptions and scans) in pediatric patients with CHD. SVR 4D flow showed good agreement with 2D PCMRI for mean flow measurements. The advantages of SVR 4D flow support further research such as its comparison with conventional 4D flow.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101887"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and sex-differences and reference values for ventricular strain by cardiovascular magnetic resonance imaging in adults without cardiovascular disease or cardiovascular disease risk factors.","authors":"Rohit Pillai, Lu Zhang, Kevin Peters, Vibhav Jha, Christopher J O'Donnell, Warren J Manning, Connie W Tsao","doi":"10.1016/j.jocmr.2025.101902","DOIUrl":"10.1016/j.jocmr.2025.101902","url":null,"abstract":"<p><strong>Background: </strong>Myocardial deformation measured by myocardial strain is an important marker of cardiovascular disease (CVD). We aimed to establish normal values and examine age- and sex-differences in left and right ventricular (LV, RV) strain using feature tracking cardiovascular resonance (FT-CMR) in adults free of CVD in the community.</p><p><strong>Methods: </strong>Framingham Heart Study Offspring participants without CVD, hypertension, or diabetes completed CMR (1.5T) (n=903, 59% (533/903) women, 36-88 years of age). Global longitudinal, circumferential, and radial strain (GLS, GCS, and GRS, respectively) were measured by semi-automated LV and RV myocardial segmentation of short-axis, 2-chamber, and 4-chamber images with cvi42 (v.5.13, Circle Cardiovascular Imaging, Calgary, Canada).</p><p><strong>Results: </strong>Mean LV GLS, GCS, and GRS were -17.8±2.5%, -19.7±2.4%, and 34.9±6.9%, respectively; RV GLS, GCS, and GRS were -20.4±4.0%, -11.7±3.5%, and 19.1±6.5%, respectively. All strain values were of greater magnitude in women than men (all p<0.005). LV and RV GCS and GRS were of greater magnitude (more negative and more positive, respectively) with increasing age (all p<0.001), but GLS was not associated with age. Stratified analysis by sex showed LV and RV GCS and GRS were greater in magnitude with increasing age in women (all p<0.001), whereas no age associations in men were observed.</p><p><strong>Conclusion: </strong>We provide FT-CMR reference values for LV and RV strain in a large, community-dwelling U.S. adult cohort free of CVD and CVD risk factors. Women demonstrated greater magnitude LV and RV GCS and GRS with increasing age. The clinical implications of sex-differences in ventricular strain and mechanical remodeling with age deserve further study.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101902"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences and determinants of coronary microvascular function in asymptomatic adults with type 2 diabetes.","authors":"Jian L Yeo, Abhishek Dattani, Joanna M Bilak, Alice L Wood, Lavanya Athithan, Aparna Deshpande, Anvesha Singh, J Ranjit Arnold, Emer M Brady, David Adlam, John D Biglands, Peter Kellman, Hui Xue, Thomas Yates, Melanie J Davies, Gaurav S Gulsin, Gerry P McCann","doi":"10.1016/j.jocmr.2024.101132","DOIUrl":"10.1016/j.jocmr.2024.101132","url":null,"abstract":"<p><strong>Background: </strong>Coronary microvascular dysfunction (CMD) is a significant complication in type 2 diabetes (T2D) and may be more common in women. We aimed to evaluate the sex differences and sex-specific clinical determinants of CMD in adults with T2D without prevalent cardiovascular disease.</p><p><strong>Methods: </strong>Single center pooled analysis of four prospective studies comparing asymptomatic people with T2D and controls. All subjects underwent comprehensive cardiovascular phenotyping with myocardial perfusion reserve (MPR) quantified with perfusion cardiovascular magnetic resonance (CMR). Participants with silent coronary disease were excluded. Multivariable linear regression was performed to identify determinants of MPR with an interaction term for sex.</p><p><strong>Results: </strong>Four hundred and seventy-nine T2D (age 57 ± 11 years, 42% [202/479] women) were compared with 116 controls (age 53 ± 11 years, 41% [48/116] women). Men with T2D, but not women, demonstrated worse systolic function and higher extracellular volume fraction than controls. MPR was significantly lower in T2D than controls (women, 2.6 ± 0.9 vs 3.3 ± 1.0, p < 0.001; men, 3.1 ± 0.9 vs 3.5 ± 1.0, p = 0.004), and lower in women than men with T2D (p < 0.001). More women than men with T2D had MPR <2.5 (46% [79/202] vs 26% [64/277], p < 0.001). There was a significant interaction between sex and body mass index (BMI) for MPR (p interaction <0.001). Following adjustment for clinical risk factors, inverse association with MPR were BMI in women (β = -0.17, p = 0.045) and systolic blood pressure in men (β = -0.14, p = 0.049).</p><p><strong>Conclusion: </strong>Among asymptomatic adults with T2D, women had a greater prevalence of CMD than men. Risk factors modestly but significantly associated with CMD in asymptomatic people with T2D were BMI among women and systolic blood pressure among men.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101132"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}