一分钟内全心磁共振成像:采用非笛卡尔超短回波时间序列的3D快速心脏MRI技术。

IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Pezad Doctor, Munes Fares, Gerald Greil, Tarique Hussain, Qing Zou
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引用次数: 0

摘要

背景:三维(3D)心血管磁共振血管造影(MRA)产生心脏及其血管周围的详细图像。然而,这项技术在儿科患者的临床环境中受到挑战,主要是由于儿科患者的不合作性质,特别是那些年幼的患者。这项工作是提出并评估一种基于非笛卡尔梯度回波的超短回波时间(UTE)序列和阿鲁莫西醇造影剂的一分钟3D全心MRI技术,用于先天性心脏病(CHD)儿科患者。方法:采用三维快速全心MRI序列和临床三维bSSFP全心序列获取阿魏木糖醇造影剂后全心成像。重新格式化血管造影的图像质量评估在3D bSSFP和3D UTE序列之间由两个阅读器独立进行。采用配对t检验进行统计分析,以评估图像质量的统计显著性。p值< 0.05为差异有统计学意义。提供了病例研究,以直观地比较所提出技术和临床3D bSSFP序列的图像。结果:38项研究在38名平均年龄为10岁(范围5个月- 24岁)的连续儿童中进行。3D UTE序列在选择用于比较的10个心脏结构中有7个得分较高。通过统计分析,确定3D UTE序列对所有肺静脉的图像质量优于3D bSSFP序列,对上腔静脉、左心房和肺动脉的图像质量与3D bSSFP序列相当。而对于左心耳和心室解剖,发现3D bSSFP序列比3D UTE序列产生更好的图像质量。结论:阿魏莫西醇增强3D UTE序列可在1分钟内完成全心成像,图像质量达到临床可接受的水平,因此可作为临床实践中3D bSSFP序列的补充工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Whole-heart MR Imaging in One Minute: 3D fast cardiac MRI technique employing the non-Cartesian Ultra-short echo time sequence.

Background: Three-dimensional (3D) cardiovascular magnetic resonance angiography (MRA) produces detailed images of the heart and its vascular surroundings. However, the technique is challenged in clinical settings for pediatric patients primarily due to the uncooperative nature of pediatric patients, especially those at young age. This work is to propose and assess a one-minute 3D whole-heart MRI technique for pediatric patients with congenital heart diseases (CHD) based on a non-Cartesian gradient-echo-based ultra-short echo time (UTE) sequence together with the ferumoxytol contrast.

Methods: Both the 3D fast whole-heart MRI sequence and the clinical 3D bSSFP whole-heart sequence were used for acquiring the whole-heart imaging post ferumoxytol contrast. Image quality assessment in reformatted angiograms was performed between the 3D bSSFP and 3D UTE sequence by two readers independently. Statistical analysis was also performed using the paired t-test to assess the statistical significance for image quality. The p-value < 0.05 was considered indicative of a statistically significant difference. Case studies were provided to visually compare images from the proposed technique and the clinical 3D bSSFP sequence.

Results: Thirty-eight studies were performed in 38 consecutive children with a mean age of 10 years [range 5 months - 24 years]. The 3D UTE sequence achieved higher scores in 7 of 10 cardiac structures chosen for comparison. Through statistical analysis, it was determined that the 3D UTE sequence offers superior image quality for all pulmonary veins and maintains comparable quality for the superior vena cava, left atrium, and pulmonary arteries compared to the 3D bSSFP sequence. While for left atrial appendage and ventricular anatomy, the 3D bSSFP sequence was found to yield better image quality compared to the 3D UTE sequence.

Conclusion: The ferumoxytol enhanced 3D UTE sequence enables whole-heart imaging in less than one minute with clinical-acceptable image quality and hence can be used as a supplemental tool for the 3D bSSFP sequence in clinical practice.

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来源期刊
CiteScore
10.90
自引率
12.50%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.
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