Coprime dual-VENC for extended velocity dynamic range in 4D Flow MRI.

IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Marta Beghella Bartoli, Sara Boccalini, David Chechin, Loic Boussel, Philippe Douek, Damien Garcia, Monica Sigovan
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引用次数: 0

Abstract

Background: In the field of cardiovascular imaging, 4D flow MRI provides non-invasive assessment of blood flow. Dual velocity encoding (dual-VENC) strategies have emerged to obtain quantitative information on both low and high blood flow velocities simultaneously. However, these strategies often encounter difficulties in coping with large velocity ranges. This work presents a dual-VENC 4D flow MRI sequence that utilizes the coprime rule to define the VENC ratio.

Methods: A dual-VENC 4D flow MRI sequence and reconstruction algorithm were developed and validated in vitro at two different field strengths, using a flow phantom generating realistic complex flow patterns. A digital twin of the phantom allowed comparison of the MRI measurements with computational fluid dynamics (CFD) simulations. Three patients with different cardiac pathologies were scanned in order to evaluate the in vivo feasibility of the proposed method.

Results: The results of the in vitro acquisitions demonstrated significant improvement in velocity-to-noise ratio (VNR) with respect to single-VENC acquisitions (110  ±  3%) and conventional dual-VENC de-aliasing approach (75  ±  3%). Furthermore, the effectiveness of aliasing correction was demonstrated even when both sets of images from the dual-VENC acquisition presented velocity aliasing artifacts. We observed a high degree of agreement between the measured and simulated velocity fields.

Conclusion: The strength of this approach lies in the fact that, unlike the conventional de-aliasing method, no data is discarded. The final image is obtained by a weighted average of the VENClow and VENChigh datasets. Consequently, setting the value of the VENChigh to prevent aliasing is no longer necessary, and higher VNR gains are possible.

在4D Flow MRI中扩展速度动态范围的copprime双venc。
背景:在心血管成像领域,4D血流MRI提供无创血流评估。双流速编码(Dual - venc)策略已经出现,可以同时获得低流速和高流速的定量信息。然而,这些策略在处理大速度范围时经常遇到困难。这项工作提出了一个双VENC 4D流MRI序列,利用协素数规则来定义VENC比率。方法:开发了双venc 4D流动MRI序列和重建算法,并在两种不同场强下进行了体外验证,使用流动模体生成了逼真的复杂流动模式。幻影的数字孪生体允许将MRI测量结果与计算流体动力学(CFD)模拟进行比较。为了评估该方法在体内的可行性,对3例不同心脏病理的患者进行了扫描。结果:体外采集结果显示,与单venc采集(110±3%)和常规双venc去混叠方法(75±3%)相比,体外采集的速度噪声比(VNR)有显著提高。此外,即使双venc采集的两组图像都存在速度混叠伪影,也证明了混叠校正的有效性。我们观察到在测量速度场和模拟速度场之间有高度的一致性。结论:这种方法的优势在于,与传统的去混叠方法不同,没有数据被丢弃。最后的图像是由VENClow和VENChigh数据集加权平均得到的。因此,不再需要设置venhigh的值来防止混叠,并且可以获得更高的VNR增益。
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来源期刊
CiteScore
10.90
自引率
12.50%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.
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