Journal of Burn Care & Research最新文献

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Impact of Heparin and Enoxaparin Anticoagulant Prophylaxis on Improving Acute Mortality in Burn Patients. 肝素和依诺肝素抗凝预防对改善烧伤患者急性死亡率的影响。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-13 DOI: 10.1093/jbcr/iraf080
Manav M Patel, Shawn E Lim, Victoria A Cuello, Joshua E Lewis, Amina El Ayadi, Michael J Erickson, Steven E Wolf, Juquan Song
{"title":"Impact of Heparin and Enoxaparin Anticoagulant Prophylaxis on Improving Acute Mortality in Burn Patients.","authors":"Manav M Patel, Shawn E Lim, Victoria A Cuello, Joshua E Lewis, Amina El Ayadi, Michael J Erickson, Steven E Wolf, Juquan Song","doi":"10.1093/jbcr/iraf080","DOIUrl":"https://doi.org/10.1093/jbcr/iraf080","url":null,"abstract":"<p><p>Burn patients have a higher chance of developing thromboembolic complications leading to worsened mortality rates so prophylactic anticoagulation is important. Anticoagulants such as enoxaparin, a low molecular weight heparin (LMWH), and unfractionated heparin (UFH) have been frequently used as chemical prophylactic treatments of thromboembolisms. Enoxaparin has been shown to have lower mortality and higher efficacy in surgical patients and coronary artery disease patients. The aim of the study is to assess mortality and compare the safety of enoxaparin and heparin in acute burn patients. A retrospective cohort study of 26572 burn patients was conducted using the TriNetX database. Patients were divided into two cohorts: those receiving only unfractionated heparin (Cohort 1) and those receiving only enoxaparin (Cohort 2) prophylaxis within 24 hours after burn injury. Cohorts were matched with 1:1 propensity score matching to correct for differences in age, gender, ethnicity, race, burn severity, inhalation injury, diabetes mellitus, acute myocardial infarction, stroke, and central line venous catheter placement. Outcomes assessed included mortality and deep vein thrombosis (DVT) within a month (30 days). After matching, the enoxaparin(n=7484) cohort showed significantly lower 30-day mortality (1.3%) compared to the UFH (n=7484) cohort (3.6%) (RR = 2.70, 95% CI: 2.15-3.40, p < 0.05). Kaplan-Meier analysis demonstrated a higher survival probability in the enoxaparin group (98.6% vs. 96.4%, p < 0.05). DVT risk was slightly higher with UFH but not statistically significant (RR = 1.18, 95% CI: 0.54-2.54, p = 0.68). Prophylactic anticoagulation with enoxaparin is associated with a significant lower 30-day mortality risk compared to unfractionated heparin.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing and consumer testing fire and burn and cold injury prevention education with people who are unhoused: EQUIP Toolkit. 针对无家可归者开展火灾、烧伤和冷伤预防教育并对其进行消费者测试:EQUIP工具包。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-13 DOI: 10.1093/jbcr/iraf082
Caitlin M Orton, Maiya I Pacleb, Tony M Machacha, Carly Marincasiu, Megan Moore, Barclay T Stewart
{"title":"Developing and consumer testing fire and burn and cold injury prevention education with people who are unhoused: EQUIP Toolkit.","authors":"Caitlin M Orton, Maiya I Pacleb, Tony M Machacha, Carly Marincasiu, Megan Moore, Barclay T Stewart","doi":"10.1093/jbcr/iraf082","DOIUrl":"https://doi.org/10.1093/jbcr/iraf082","url":null,"abstract":"<p><p>Fifteen percent of people receiving care for major burn injuries in urban burn centers across North America were homeless pre-injury. The number and risk of such injuries are increasing due to greater numbers of people experiencing homelessness (PEH) and frequency of extreme climate events. Prevention education, along with passive and active fire and cold weather protections are critical for preventing these injuries. To increase acceptability, understandability, and actionability, prevention education needs to be in plain language, contextualized, and consumer-tested. We aimed to test newly developed fire and burn and cold injury prevention education materials with PEH and gain insights for preferred prevention strategies to address and mitigate related risks and hazards. Forty cognitive interviews with PEH were conducted. The Model System Knowledge Translation Center's consumer-testing toolkit was used to evaluate understandability and actionability of the education materials. Transcripts were analyzed using a harm reduction framework and deductive and inductive thematic coding. Themes were: 1) engage - being approachable and accessible, 2) use context-specific design to enhance relatability - reflect the lived experiences of PEH and their environments, 3) reduce harm - focus on mitigating rather than eliminating hazards, 4) empower - incorporate prevention guidance, guided by PEH in combination with conventional prevention strategies, and 5) integrate - disseminate prevention education and PEH preferred safety equipment within services and locations utilized by PEH. The process of consumer-testing with PEH generated acceptable fire, burn and cold injury prevention and mitigation strategies. These strategies were used to develop actionable prevention education materials.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burn violence against women in Australia: The tip of the iceberg from Australian burn centres. 澳大利亚针对妇女的烧伤暴力:来自澳大利亚烧伤中心的冰山一角。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-13 DOI: 10.1093/jbcr/iraf081
Yvonne Singer, Lincoln M Tracy, Claudia Malic, Lisa Martin, Belinda Gabbe, Heather Douglas
{"title":"Burn violence against women in Australia: The tip of the iceberg from Australian burn centres.","authors":"Yvonne Singer, Lincoln M Tracy, Claudia Malic, Lisa Martin, Belinda Gabbe, Heather Douglas","doi":"10.1093/jbcr/iraf081","DOIUrl":"https://doi.org/10.1093/jbcr/iraf081","url":null,"abstract":"<p><p>Violence against women is pervasive. An estimated 25% of Australian women (≥ 15 years) have experienced intimate partner violence. Recent cases of homicidal burn violence perpetrated against Australian women have shocked the nation. However, little evidence exists about the burden of burn violence against Australian women. This study describes and compares the frequency, sociodemographic profile, injuries, and outcomes of women admitted to Australian burn centres with burns from suspected violence with women with unintentional burns. Data were extracted from the Burns Registry of Australia and New Zealand for women (≥ 18 years) admitted to Australian burn centres between 2009 and 2022, with burns from suspected violence or unintentional burns. Socio-demographic profiles, injury, and in-hospital outcomes were compared. To further explore group differences, 155 women from each group were propensity score matched (one-to-one basis), with subsequent group comparisons made. Of 6262 women meeting inclusion criteria, few reported burns from suspected violence (2.5% versus 97.5%). Women with burns from suspected violence were younger (median 36 vs 43 years), greater proportions sustained flame burns (38.1% vs 25.3%) involving petrol (80.0% vs 38.0%), their injuries more likely involved their head (42.3% vs 16.4%), and a greater proportion died (4.5% versus 1.5%). Perpetrators were most often intimate partners. Our study contributes to emerging international literature demonstrating the confronting nature and consequences of burn violence against women. Building capacity amongst burn centre teams to identify and respond to suspected burn violence will better protect Australian women and aligns with national plans to end violence against women.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Pilot Study of Microcolumn Skin Grafting in Full-thickness Burns. 全层烧伤微柱植皮的初步研究。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-10 DOI: 10.1093/jbcr/iraf075
Martin R Buta, Matthew Supple, Sean Hickey, Jonathan S Friedstat, John T Schulz, Edward A Bittner, Joshua Tam, Jeremy Goverman
{"title":"A Pilot Study of Microcolumn Skin Grafting in Full-thickness Burns.","authors":"Martin R Buta, Matthew Supple, Sean Hickey, Jonathan S Friedstat, John T Schulz, Edward A Bittner, Joshua Tam, Jeremy Goverman","doi":"10.1093/jbcr/iraf075","DOIUrl":"https://doi.org/10.1093/jbcr/iraf075","url":null,"abstract":"<p><p>This pilot study evaluated the feasibility of treating third-degree, full-thickness burn wounds with both split-thickness skin grafts (STSGs) and micro skin tissue columns (MSTC). Donor sites for both grafting techniques were also assessed. Patients aged ≥18 years with ≤60% total body surface area (TBSA) third-degree, full-thickness burns were enrolled. One 2.5 x 2.5 cm2 wound area was treated in each subject, with the remaining portion of the wound used as an internal control. The target wound was treated with MSTCs + STSG while the control site was treated with STSG. Patients were followed for up to nine months after wound closure. Primary endpoints included re-epithelialization rate (RER), scarring (Vancouver Scar Scale, Patient and Observer Scar Assessment Scale), and donor site pain (visual analogue scale). Ten patients were enrolled. Overall, MSTC donor sites were less painful, epithelialized faster, and resulted in improved POSAS and VSS scores than STSG donor sites. For all endpoints, there were no differences in the recipient wounds grafted with or without MSTCs. Intraoperative MSTC grafting is feasible and results in minimal donor site morbidity. This pilot study was unable to demonstrate enhanced wound healing or reduced scar formation when MSTCs were applied simultaneously with STSGs to burn wounds. Larger clinical studies are needed to assess the utility of MSTCs in conjunction with STSGs.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive Fungal Infection Increases Mortality Risk After Burn Injury. 侵袭性真菌感染增加烧伤后死亡风险。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-10 DOI: 10.1093/jbcr/iraf047
Allison B Frederick, Savannah H Skidmore, Aaron P Lesher, Steven A Kahn, Rohit Mittal
{"title":"Invasive Fungal Infection Increases Mortality Risk After Burn Injury.","authors":"Allison B Frederick, Savannah H Skidmore, Aaron P Lesher, Steven A Kahn, Rohit Mittal","doi":"10.1093/jbcr/iraf047","DOIUrl":"https://doi.org/10.1093/jbcr/iraf047","url":null,"abstract":"<p><p>While invasive fungal infections (IFIs) can be deadly for any hospitalized patient, a high-risk subset are those with burn injuries due to their immunocompromised state, and an increasing number of non-Candida infections have been on the rise. This novel study captures data from across the United States using a multi-institutional dataset derived from electronic health record data and is the largest study to date evaluating mortality associated with fungal infections in burn injury. Inclusion criteria identified all patients with burn injury from 2002 to 2024; IFI was defined as a diagnosis of fungal mycosis with systemic antifungal treatment which was compared to a control cohort of burn patients without mycoses or antifungal treatment. The cohorts were then propensity-matched for gender, age, and percent total body surface area (%TBSA). The unmatched fungal infection cohort contained 3325 patients while the control cohort contained 50 5421. After propensity matching, the 1-year mortality rate for all burn patients with fungal infection was 18.5% compared to 1.9% in controls (risk ratio: 9.8, 95% confidence interval, 7.2-13.2; P < .0001). Additionally, when stratified by %TBSA there was a stepwise increase in mortality: 21.6% for <10% TBSA (P < .0001), 29.0% for 10%-49% TBSA (P < .0001), and 33.1% for >50% TBSA (P = .2). The 3 most common and deadly infections among all burn patients were Aspergillus, invasive Candida, and unspecified mycoses. In all burns, fungal infection was associated with a nearly 10-fold increase in mortality. An incremental increase is noted when stratified by %TBSA and even <10% TBSA burns have an over 20% risk of mortality.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous chemical burns: Water irrigation first aid improves short term outcomes. 皮肤化学烧伤:水冲洗急救改善短期结果。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-10 DOI: 10.1093/jbcr/iraf079
Hayley Chai, Lisa Martin, Rachel Kornhaber, Leila Cuttle, Mark Fear, Fiona Wood
{"title":"Cutaneous chemical burns: Water irrigation first aid improves short term outcomes.","authors":"Hayley Chai, Lisa Martin, Rachel Kornhaber, Leila Cuttle, Mark Fear, Fiona Wood","doi":"10.1093/jbcr/iraf079","DOIUrl":"https://doi.org/10.1093/jbcr/iraf079","url":null,"abstract":"<p><p>First aid recommendations for chemical burns include copious water irrigation for 30 minutes to 2 hours after removal of the substance from skin. The aim of this retrospective analysis was to assess the efficacy of water irrigation on short-term outcomes for chemical burn injuries. Data from the Australian and New Zealand Burn registry (2009-2020) were analysed to categorize the application of running water for first aid for presence, timing of application post-injury and duration. The timing of first aid application was classified into whether the application was prehospital or in-hospital. Multivariate regression analyses then evaluated how water irrigation affected hospital stay, ICU admission, and the necessity for acute surgery for wound closure. Among 1,549 chemical burn patients, for those who received in-hospital first aid their stay was reduced by about 18% compared to those who did not. Patients receiving pre-hospital or in-hospital first aid had 37% and 31% lower odds, respectively, of needing acute care surgery for wound closure compared to those who did not. There was no evidence that first aid provision influenced the need for intensive care admission. Water irrigation is associated with shorter hospital stays and reduced acute care surgery for wound closure following chemical burns, without impacting intensive care admission rates.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Randomized, Controlled Trial Comparing PermeaDerm to Mepilex Ag for the Treatment of Adult and Pediatric Partial-Thickness Burns. 一项随机对照试验比较透皮素和美派乐治疗成人和儿童部分厚度烧伤的疗效。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-08 DOI: 10.1093/jbcr/iraf013
David G Greenhalgh, David M Hill, Ram Velamuri, Ian Driscoll, Angela Gibson, Kevin Foster, David Smith, Aleisha Chamberlain, Katie Bush, Miao Yu
{"title":"A Randomized, Controlled Trial Comparing PermeaDerm to Mepilex Ag for the Treatment of Adult and Pediatric Partial-Thickness Burns.","authors":"David G Greenhalgh, David M Hill, Ram Velamuri, Ian Driscoll, Angela Gibson, Kevin Foster, David Smith, Aleisha Chamberlain, Katie Bush, Miao Yu","doi":"10.1093/jbcr/iraf013","DOIUrl":"https://doi.org/10.1093/jbcr/iraf013","url":null,"abstract":"<p><p>A next-generation transparent biosynthetic wound matrix (PermeaDerm) was developed for the treatment of burn injuries. Improvements include slits in an outer 2D silicone epidermal analog allowing for customizable moisture control, and an updated biocoating of the nylon knitted fabric to optimize wound adherence. The purpose of this randomized, single-blinded, multicenter trial was to compare PermeaDerm to a commonly used silver-containing foam dressing (Mepilex Ag) for the treatment of partial-thickness burns. Patients with partial-thickness burns <30% TBSA treated within 72 hours were included. Primary outcomes included incidence of 100% re-epithelialization at 14 days and time to conversion to alternative therapy. Secondary outcomes included incidence of healing at 7 and 21 days, pain, number of product changes, and adverse events. Sixty-seven patients (42 pediatric, 25 adult) were analyzed, 32 with Mepilex Ag and 35 with PermeaDerm. Though not statistically significant, more patients achieved healing with PermeaDerm at day 14 (P = 0.36), particularly those with superficial partial-thickness injuries (OR 5.87, P = 0.203, 95% CI = 0.385, 89.580). This trend continued to day 21 (P = 0.25). At day 7, nonsignificant increased incidence of healing of Mepilex Ag-treated wounds was observed (P = 0.25), in addition, PermeaDerm was associated with lower needs for product changes (OR 0.15, P = 0.034, 95% CI = 0.027, 0.872); both observations likely attributable to the adherent nature of PermeaDerm. No significant differences in time to conversion to alternate therapies were noted. Overall pain scores, aesthetics, and adverse events, including infection, were similar between groups. PermeaDerm is a safe and effective treatment for partial-thickness burns. PermeaDerm offers the clinical advantages of being transparent to continuously monitor the wound and adherent, reducing the need for a product change and allowing for bathing after 72 hours.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dilution is not always the solution: A retrospective study of pulmonary lavage in inhalation injury. 稀释并不总是解决办法:吸入性损伤肺灌洗的回顾性研究。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-08 DOI: 10.1093/jbcr/iraf078
Ashleigh Bull, Colette Galet, Samuel W Jones, Alexander Kurjatko
{"title":"Dilution is not always the solution: A retrospective study of pulmonary lavage in inhalation injury.","authors":"Ashleigh Bull, Colette Galet, Samuel W Jones, Alexander Kurjatko","doi":"10.1093/jbcr/iraf078","DOIUrl":"https://doi.org/10.1093/jbcr/iraf078","url":null,"abstract":"<p><p>Burned patients with inhalation injury commonly undergo bronchoscopy, at times with pulmonary lavage (PL). We characterized the outcomes of burned patients with inhalation injury who underwent PL at a single burn center in a retrospective cohort study. We included all adult patients admitted between July 1, 2015 to June 30, 2023 who were on the ventilator and diagnosed with inhalation injury. Chemical inhalation, grade 0 inhalation injury, and diagnosis of inhalation injury without bronchoscopy were excluded. Demographics, burn size and anatomic location, and hospital course information were collected. Chi-square and Fisher exact tests were used to compare categorical variables, and continuous variables were compared using the Mann-Whitney U test. Multivariate analyses were performed to identify variables associated with outcomes. P < 0.05 was considered significant. One hundred sixteen patients were included; 37 (31.9%) underwent PL. Univariate analysis showed no significant differences in age, total body surface area burned (TBSA) 2nd or 3rd degree TBSA, complication rates, or in-hospital mortality between the no-PL and PL groups. Patients in the PL group had increased ventilator days (6 [2.5-15.5] vs. 2 [1-6], p < 0.001) and hospital length of stay (LOS) (12 [4-37.5] vs. 5 [2-18], p = 0.003). Multivariate analysis showed that PL was associated with an increase in ventilator days (OR = 1.84 [1.14-2.98], p = 0.013), hospital LOS (OR = 1.717 [1.080-2.730], p = 0.022), and sepsis (OR = 7.216 [1.106-47.080], p = 0.039). In conclusion, PL was associated with longer ventilator days, longer LOS, and increased risk of sepsis.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burn Surgery Bibliometric Analysis of Research Funding at American Burn Association-Verified Burn Centers. 美国烧伤协会认证的烧伤中心研究经费的烧伤外科文献计量学分析。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-04 DOI: 10.1093/jbcr/iraf072
Tiffany Jeong, Nicolas M Kass, Hilary Y Liu, Mare G Kaulakis, Christopher J Fedor, Jose Antonio Arellano, J Peter Rubin, Francesco M Egro
{"title":"Burn Surgery Bibliometric Analysis of Research Funding at American Burn Association-Verified Burn Centers.","authors":"Tiffany Jeong, Nicolas M Kass, Hilary Y Liu, Mare G Kaulakis, Christopher J Fedor, Jose Antonio Arellano, J Peter Rubin, Francesco M Egro","doi":"10.1093/jbcr/iraf072","DOIUrl":"https://doi.org/10.1093/jbcr/iraf072","url":null,"abstract":"<p><p>Evidence-based burn surgery and management rely on high-quality research to inform practice and policy. However, burn surgical research is costly, and the distribution of American Burn Association (ABA)-verified burn centers is unequal. This study examines the relationship between research funding, productivity, and ABA-verification in burn surgery. PubMed was queried for all burn surgery/reconstruction articles, collecting data on article title, funding, type, and affiliation. ABA-verified burn centers and their academic affiliations were identified via the ABA website and Google search. The query identified 16,138 burn surgery articles, with 3001 affiliated with US institutions and published in 1,785 journals. Notable journals include Burns (n=2,992) and Journal of Burn Care and Research (n=1,558). Only 16.6% of articles reported grant funding, primarily from non-U.S. government sources. High-level evidence (clinical trials and systematic reviews/meta-analyses) comprised 2.7% of articles but were more likely to be funded (32.4% vs. 16.1%, p<0.001). Articles from ABA-verified centers represented 13.5% of publications and were significantly more likely to receive funding (30.5% vs. 14.4%, p<0.001). ABA affiliation doubled the odds of research funding (OR: 2.014, p<0.001), and U.S.-based institutional affiliation increased funding odds by 122.8% (OR: 2.228, p<0.001). High level evidence comprises a minority of articles in burn surgery literature but are significantly associated with research funding. Furthermore, ABA-verified burn centers have a higher percentage of their research funded. While we are unable to elucidate whether ABA verification or research funding drives this phenomenon, it remains clear that high level burn surgery research, funding, and ABA-verification often coexist.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-burn lung inflammation is associated with induction of pulmonary cathelicidin-related antimicrobial peptide and S100a8 in mice. 烧伤后肺部炎症与小鼠肺部抗菌肽相关抗菌肽和S100a8的诱导有关。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-04 DOI: 10.1093/jbcr/iraf069
Shanawaj Khair, Kevin M Najarro, Travis M Walrath, David J Orlicky, Rachel H McMahan, Elizabeth J Kovacs
{"title":"Post-burn lung inflammation is associated with induction of pulmonary cathelicidin-related antimicrobial peptide and S100a8 in mice.","authors":"Shanawaj Khair, Kevin M Najarro, Travis M Walrath, David J Orlicky, Rachel H McMahan, Elizabeth J Kovacs","doi":"10.1093/jbcr/iraf069","DOIUrl":"https://doi.org/10.1093/jbcr/iraf069","url":null,"abstract":"<p><p>Burn trauma triggers dysregulated systemic inflammation, leading to multi-organ dysfunction. Respiratory failure often follows burn injury, resulting in morbidity and mortality, in part, because of excessive and prolonged release of local and systemic pro-inflammatory mediators. One class of important mediators of inflammation at mucosal surfaces are antimicrobial peptides (AMPs), and their expression is notably altered in inflammation. We sought to determine whether pulmonary AMPs are induced in inflammatory lung after burn. C57BL/6 male mice were given a 12-15% full thickness total body surface area dorsal scald burn or sham injury. Survival rate and pulmonary function of the mice were assessed at 24 hours. Histopathological examination and quantification of pro-inflammatory mediators, IL-6 and CXCL1, in the lungs at 24 hours after burn were performed. mRNA expression of a subset of prominent lung AMPs in whole lung, alveolar macrophages, and primary lung epithelial cells were measured. Our data showed decreased survival and impaired respiratory function after burn injury. Moreover, hematoxylin and eosin-stained lung sections of burned mice showed pulmonary edema and congestion, and pulmonary IL-6 and CXCL1 were elevated. AMP analysis revealed that burn triggered a dramatic rise in lung Camp and S100a8 above that of sham mice. To our surprise, lung epithelial cells, and not alveolar macrophages, were the cellular source of burn-induced Camp and S100a8 in this murine model of burn injury. Taken together, these data reveal for the first time that lung inflammation post-burn involves a rise in AMPs, Camp and S100a8, from lung epithelial cells.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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