Journal of Burn Care & Research最新文献

{"title":"Charles Goldhamer and the Visual Record of Wartime Burn Care.","authors":"Alan D Rogers, John L Semple","doi":"10.1093/jbcr/irag145","DOIUrl":"https://doi.org/10.1093/jbcr/irag145","url":null,"abstract":"<p><p>The Second World War generated a distinctive population of aircrew survivors with severe burns of the face and hands who required prolonged reconstruction and rehabilitation. At Queen Victoria Hospital, East Grinstead, Canadian official war artist Charles Goldhamer portrayed this clinical world between 1944 and 1946. His works have often been interpreted as humane records of burn survivorship, but their historical significance is clearer when they are placed within the longer visual history of reconstructive surgery. This historical review compares six Goldhamer works in the Canadian War Museum with nineteenth-century surgical illustration and photography, the First World War records of Harold Gillies and Henry Tonks, and the operative drawings of Mollie Lentaigne at East Grinstead. Goldhamer did not inaugurate the visual documentation of disfigurement or reconstruction. His distinct contribution was to bring an established clinical-artistic tradition into an official national war-art programme and to emphasize rehabilitation, postoperative waiting, staged reconstruction, and the recovering patient rather than only deformity, technique, or final result. Museum inscriptions also provide case-specific information for selected sitters, including Flying Officer John Smith and Sergeant James F. Gourley. After 1945, clinical photography and professional medical illustration became the dominant means of surgical documentation, while Goldhamer returned to teaching and painting. His burn series therefore represents both continuity with earlier medical art and a distinctive wartime convergence of clinical record, portraiture, and public memory.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Value of Screening and Decolonization in Burn Unit Management.","authors":"Chinaemelum C Akpunonu, Yueran Zhang, Jemima Carroll, Beth McGuire, Michael R Young, Nidhi Aravapalli, Shandra Day, Ariel Rodgers, John Loftus, Nicole P Bernal","doi":"10.1093/jbcr/irag121","DOIUrl":"https://doi.org/10.1093/jbcr/irag121","url":null,"abstract":"<p><p>Methicillin-resistant Staphylococcus aureus (MRSA) is consistently associated with more severe wound complications and worse outcomes in burn patients. Many burn centers who have implemented routine MRSA screening and decolonization protocols have reported reduced MRSA transmission, lower rates of device-associated infections such as CAUTI and CLABSI, and decreased LOS. At the Ohio State University, Wexner Medical Center (OSUWMC), we initiated a multidisciplinary quality improvement two-phase project to implement routine screening. Phase 1: all patients who screened positive for MRSA received a decolonization protocol consisting of intranasal mupirocin twice daily for 5 days and daily chlorhexidine gluconate baths; Phase 2: all patients were screened but no decolonization measures were taken. We aimed to determine if MRSA decolonization aids in decreasing incidence of MRSA, LOS, and incidence of wound infections. Phase 1: 45 patients were admitted in March 2025, with 93% compliance for admission MRSA screening (n = 36). 19 (49%) were negative, 10 (26%) were MSSA+, and 7 (18%) were MRSA+. All MRSA+ patients completed the decolonization protocol. Only 2 of the 45 patients (4%) developed MRSA wound infections requiring treatment. Phase 2: 103 patients from July-September 2025, with a 52.4% compliance rate for screening on admission (n = 54). 36 (66.7%) were negative, 5 (9.3%) were MRSA+, and 13 (24.1%) were MSSA+. 13 patients developed non-MRSA wound infections. No differences in length of stay, LOS/TBSA, incidence of infection by screened result or TBSA (once adjusted) or mortality were observed in either phase. The additional cost and resource utilization required for screening and decolonization did not appear to provide meaningful clinical advantage.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Acuity and Anesthesia: A Novel Tiered Framework for Anesthetic Stratification in Operative Burn Management.","authors":"Nicole Margiotta, Lane L Palmisano, Cherry Song, Abraham Houng","doi":"10.1093/jbcr/irag136","DOIUrl":"https://doi.org/10.1093/jbcr/irag136","url":null,"abstract":"<p><p>Burn injuries vary widely in clinical severity, operative complexity, and physiologic burden. Although scoring systems exist for predicting morbidity and mortality in burn patients, a standardized framework for coordinating burn case acuity with anesthesia expertise has yet to be implemented in clinical practice. In this retrospective, single-center study, we analyzed 132 operative burn cases performed over a one-year period to evaluate a novel tiered classification system that stratifies anticipated anesthesia requirements by clinical severity. Cases were categorized as Green (low risk), Yellow (moderate risk), or Red (high risk) based on physiologic risk factors, including burn extent as percentage of total body surface area (TBSA), hemodynamic instability, and vasopressor dependence. Patient demographics and clinical variables, including age, mechanism of injury, TBSA, and intraoperative transfusion requirements were collected and statistically analyzed. Results showed that the pediatric cohort (<18 years old) demonstrated significantly greater mean TBSA burns (43.3% vs. 21.8%, p=0.0017, 95% CI [-33.70, -9.00]) and represented a higher proportion of Red-tier (high-risk) cases than adult patients (p=0.0011), with a similar mechanism of injury observed across cohorts (p=0.50). A statistically significant difference was observed in the distribution of intraoperative blood product administration across severity tiers (p<0.001). The findings of this study suggest that the proposed tiered system identifies clinically distinct groups of operative burn cases based on injury severity and physiologic instability. We propose that implementing this framework in clinical practice may improve outcomes for patients with acute burns, facilitate more efficient allocation of anesthesia resources, and guide standardized educational structures for management of acute burn injuries.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-engineered extracellular vesicles for burn wound repair: burn-specific design and translational perspectives.","authors":"Xinrui Jin, Jing Wang","doi":"10.1093/jbcr/irag133","DOIUrl":"https://doi.org/10.1093/jbcr/irag133","url":null,"abstract":"<p><p>Burn wound healing remains a major clinical challenge. Mesenchymal stem cell-derived extracellular vesicles engineered to deliver defined microRNA cargo or modulate endogenous microRNA profiles have emerged as promising cell-free therapeutics, but native extracellular vesicle preparations remain constrained by low yield, heterogeneity, insufficient targeting, and incomplete cargo control. Moreover, much of the current evidence still comes from non-burn wound models. This review presents a burn-oriented framework that aligns upstream parental-cell programming, downstream vesicle modification, and biomaterial-assisted delivery with key burn-specific barriers, including burn depth, eschar, infection, hypoxia, systemic inflammation, inhalation injury, grafting requirements, and temporal immune dysregulation across the systemic inflammatory response syndrome-to-compensatory anti-inflammatory response syndrome transition. We also discuss translational requirements that are often underemphasized in general wound-healing reviews, including dose scaling for large total body surface area burns, repeat application, compatibility with debridement and grafting, storage and thawing in burn centers, sterility, use in infected wounds, and whether local extracellular vesicle delivery can mitigate systemic dysfunction. Overall, microRNA-engineered extracellular vesicles are a versatile platform for burn wound repair; however, clinical translation remains speculative without large-animal, infected-burn, grafting, long-term scar, and human safety data.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain and Pruritus Increase Long-Term Psychosocial Morbidity in Pediatric Burn Survivors.","authors":"Anika Y Kim, Bill Insko, Kara McMullen, Sarah A Stoycos, Karen Kowalske, Colleen Ryan, Jeffrey C Schneider, Gretchen J Carrougher, Haig A Yenikomshian","doi":"10.1093/jbcr/irag137","DOIUrl":"10.1093/jbcr/irag137","url":null,"abstract":"<p><strong>Introduction: </strong>While pain and pruritus are well-established sequelae of burn injury, their downstream impact on pediatric burn survivors is poorly characterized. This project addresses this gap by evaluating associations of pain and pruritus with functional and psychosocial symptoms at 12 months post-injury in pediatric burn survivors.</p><p><strong>Methods: </strong>Using a multicenter longitudinal database (injured between 2014 and 2024), this retrospective review identified pediatric burn survivors aged 8-17 years who completed a self-reported survey assessing pain and pruritus at 12-months post-injury. Patient-Reported Outcomes Measurement Information System (PROMIS) domains included pain intensity, pruritus, physical function, anxiety, depression, and fatigue. General linear models (GLM) were fitted at the 12-month follow-up to evaluate independent associations between pain and pruritus scores and demographic, functional, and psychosocial variables.</p><p><strong>Results: </strong>The study included 67 pediatric burn survivors with a mean age of 11.8 ± 2.9 years. In multivariate regression models at 12 months post-injury, demographic and burn characteristics were not significant predictors of pain or pruritus. Both higher pain and itch were significantly associated with greater anxiety (p = 0.0109; p < 0.0001), depression (p = 0.0021; p = 0.0006), and fatigue (p = 0.0053; p = 0.0096); higher itch was additionally associated with worse physical function (p = 0.0396).</p><p><strong>Conclusions: </strong>This review shows that even one year after injury, pain and pruritus remain strongly associated with psychosocial distress, with pruritus additionally linked to impaired physical function. These findings highlight that pain and itch are interrelated drivers of impaired quality of life in children.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Anxiety, Mental and Physical Health Related Quality of Life at One Year and Two Years after Injury in Adult Burn Survivors - A Burn Model System National Database Study.","authors":"Patricia Tasha Champagne, Yi-Ting Tzen, Spoorthi Sadasivuni, Jijia Wang, Julia Bryarly, Kimberly Roaten, Karen Kowalske","doi":"10.1093/jbcr/irag135","DOIUrl":"https://doi.org/10.1093/jbcr/irag135","url":null,"abstract":"<p><p>Adult burn survivors are at risk for developing anxiety and reduced health-related quality of life. The purpose of the study was to investigate predictors of anxiety at one- and two-years post injury. Data from 266 patients were queried from the Burn Model System National Database between 2015-2020. Patient-reported outcomes at one- and two-years post injury were analyzed using the Patient-Reported Outcomes Measurement Information System (PROMIS-29) for anxiety severity, and the Mental Component Summary (MCS) and Physical Component Summary (PCS) for mental and physical health-related quality of life respectively. Logistic models were computed to determine predictors of anxiety at one- and two-years post injury. Results showed that at one-year post injury, burns to specific body regions and pre-existing diagnoses of mental health disorders predict high anxiety severity scores and low MCS scores, whereas burns at perineum area predict low PCS scores. At two-years post injury, younger age predicted low MCS scores, and burns to the leg area, older age, and pre-existing diagnosis of diabetes predict low PCS scores. Findings from this study showed that burns to visible areas, pre-existing mental health disorders, and younger age predict increased anxiety and lower mental-health related quality of life, whereas burns to the perineum and lower limbs, and older age predict lower physical-health related quality of life. Therefore, allocating mental and physical health-related resources to burn survivors based on burn area, age, and comorbidities is crucial for quality of life after burn injury.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Zwitterionic Hydrogels for Antimicrobial Efficacy in a Controlled Porcine Burn Wound Infection Model.","authors":"Babita Parajuli, Amy Wang, Kelsey Fiddes, Patrick Walker, Timothy S Horseman, David M Burmeister","doi":"10.1093/jbcr/irag142","DOIUrl":"https://doi.org/10.1093/jbcr/irag142","url":null,"abstract":"<p><p>Burn injuries impose significant healthcare and logistical burdens in both civilian and military settings. This includes infectious complications that are amplified in prolonged field care environments where surgical intervention is delayed. As such, there is a growing need for adjunctive therapies that mitigate infection and zwitterionic (ZW) hydrogels offer a promising solution for maintaining a moist wound environment and reducing bacterial colonization. This study evaluates the safety and efficacy of two ZW hydrogel products: CleraFlexTM and a ZW hydrogel loaded with polyhexamethylene biguanide (PHMB) in infected burns in swine under simulated prolonged field care conditions. Ten-5x5cm contact burns were created on the dorsum of Yorkshire-cross swine (n=3) and inoculated with Pseudomonas aeruginosa (ATCC #27853, 2.5 x 105 CFU). Wounds were treated with saline, triple antibiotic ointment (TAO), CleraFlex, or ZW + PHMB. Photographs and biopsies were obtained. On day 7 post-burn, wounds appeared infected due to greenish discoloration to varying degrees. Saline-treated wounds had the highest bacterial burden (9.38±0.40 log CFU/g). TAO treatment resulted in a non-significant reduction to 6.95±0.63 log CFU/g (p=0.078), whereas CleraFlex and ZW + PHMB achieved greater significant reductions (6.39±0.36 log CFU/g and 5.98±0.65 log CFU/g, respectively; (p<0.05 and p<0.01). Blinded histological analysis also showed reduced leukocyte extravasation, and potentiated removal of the necrotic eschar in burn wounds treated with ZW +/- PHMB. ZW formulations +/- PHMB significantly reduced bacterial burden in a porcine burn-infection model simulating prolonged field care, supporting their potential as effective adjuncts in managing infection during delayed evacuation in austere environments.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Matched Group Comparison of the Use of Autologous Skin Cell Suspension in Geriatric Burn Patients.","authors":"Megan Newsom, Joseph Lewcun, Na Bo, Zachary Brown, D O Prabhu Senthil-Kumar, Michael Feldman","doi":"10.1093/jbcr/irag143","DOIUrl":"https://doi.org/10.1093/jbcr/irag143","url":null,"abstract":"<p><p>There is an increasing population of geriatric burn patients, and burns in this population are more morbid. Autologous skin cell suspension is an adjunct to autografting, which uses an 80:1 expansion of skin cells. The purpose of this investigation was to evaluate the ability of autologous skin cell suspension to augment wound healing in burn patients 65 years or older. We performed a single-center retrospective review of geriatric burn patients who underwent surgical treatment between January 2020 and October 2024. We identified burn patients aged 65 or older who were treated with autografting and an autologous skin cell suspension and matched them to a group that received autografting alone based on age, gender, comorbidity index, total body surface area burn, and number of days on a ventilator. The primary outcome was the achievement of 95% re-epithelialization of the primary burn wound at 4 weeks. Secondary outcomes included time to wound healing, autograft mesh ratio, graft thickness, autograft area, recipient wound characteristics, and postoperative complications. Twenty-seven patients were included in each cohort. Most patients achieved 95% re-epithelialization at 4 weeks. Time to wound healing and the proportions of patients that healed by 4 weeks were the same between the groups. However, ASCS use was independently associated with utilization of higher mesh ratios (OR 6.37, 95% CI 1.61-25.15; p = 0.0082), and high mesh ratios (≥3:1) were used more frequently in the ASCS cohort (29.0% compared to 3.7%, p = 0.0142). Patients treated with ASCS also received significantly thinner split-thickness skin grafts (p < 0.001). Autograft area, recipient wound bed composition, anatomic wound location, and postoperative complication rates were similar between groups. Although ASCS was not associated with improved early wound healing in this cohort, its use was associated with thinner split-thickness skin grafts and higher autograft mesh ratios without prolonging time to healing. These findings suggest that ASCS may facilitate the use of thinner grafts and higher mesh ratios while maintaining comparable early wound healing geriatric burn patients.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Cost and Patient Charges at a Regional Burn Center.","authors":"Kaitlyn Malek, Tony Zhao, Anjay Khandelwal","doi":"10.1093/jbcr/irag140","DOIUrl":"https://doi.org/10.1093/jbcr/irag140","url":null,"abstract":"<p><p>Burn injuries present significant public health and economic challenges in the United States. This study aimed to evaluate the key drivers of burn care costs by assessing relative changes in variable direct costs (VDC). A retrospective review of burn patients treated between 2022 and 2023 was conducted using cost and clinical data from hospital financial records. Patient demographics and clinical variables, including age, total body surface area, length of hospital stay, number of days on a ventilator, number of procedures, number of complications, number of comorbidities, and presence of inhalation injury, were analyzed. Univariate and multivariate quantile regression analyses were performed at the 25th, 50th, and 75th percentiles of VDC to examine how clinical factors influence cost variation across the cost distribution. The median age of patients was 39 years, with 66.2% being male. The median total body surface area affected was 3.7 percent, and the median length of hospital stay was 5 days. Length of stay and number of procedures were consistent predictors of increased VDC across all cost percentiles, demonstrating proportional increases in cost with greater resource utilization. At higher cost percentiles, prolonged ventilator use of four or more days demonstrated amplified effects on VDC, while procedural burden remained the strongest independent driver of increased costs after adjustment. The primary drivers of increased VDC included length of hospital stay, number of procedures, ventilator use, and overall clinical severity, particularly among high-cost patients. Targeted strategies aimed at reducing hospital length of stay and optimizing procedural utilization may help mitigate variable direct costs. Evaluating cost drivers across the VDC distribution provides critical insight for improving cost prediction, guiding resource allocation, and maintaining high-quality burn care.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin attenuates burn-wound progression by inhibiting inflammation via mitophagy-related pathway.","authors":"Weixue Jin, Danyang Ren, Celia Ho, Meirong Yu, Songxue Guo","doi":"10.1093/jbcr/irag132","DOIUrl":"https://doi.org/10.1093/jbcr/irag132","url":null,"abstract":"<p><p>Burn-wound progression contributes to early deterioration of burn severity and is closely associated with oxidative stress-induced inflammation in the zone of stasis, where mitochondria play a central role in regulating inflammatory responses and tissue damage. Melatonin is known to exert antioxidant and anti-inflammatory effects and to protect organelles from injury, suggesting a potential role in mitigating ischemia-related tissue damage. In this study, a \"comb\" scald rat model was used to investigate whether melatonin could prevent early burn-wound progression and to elucidate the underlying mechanisms. Melatonin was administered intraperitoneally at different doses immediately after injury, and wound conversion was assessed by histological analysis. Oxidative stress markers, inflammatory cytokines, and autophagy/mitophagy-related signals were evaluated using ELISA, immunostaining, qRT-PCR, and western blotting, with additional pharmacological modulation of autophagy and mitophagy to clarify mechanistic involvement. The results showed that melatonin significantly attenuated burn-induced activation of the HMGB1-NLRP3 inflammasome and reduced inflammatory cytokine release, while also alleviating oxidative stress, as indicated by decreased malondialdehyde (MDA) levels and restored superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. These protective effects were closely associated with preservation of mitochondrial integrity and regulation of reactive oxygen species (ROS) through autophagy, particularly PINK1-PARKIN-dependent mitophagy. Importantly, the autophagy inhibitor 3-MA abolished the beneficial effects of melatonin, confirming the essential role of autophagy-related pathways. Together, these findings demonstrate that melatonin prevents early burn-wound progression by promoting mitophagy-mediated mitochondrial repair and suppressing downstream inflammatory responses.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}