Journal of Burn Care & Research最新文献

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Sexual Function, Body Image, and Quality of Life After Genital Burns: A Burn Model System Database Study. 生殖器烧伤后的性功能、身体形象和生活质量:一个烧伤模型系统数据库研究。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-04 DOI: 10.1093/jbcr/iraf070
Dania Johnson, Andrew Humbert, Kimberly Roaten, Shelley Wiechman, Jeffrey C Schneider, Haig A Yenikomshian
{"title":"Sexual Function, Body Image, and Quality of Life After Genital Burns: A Burn Model System Database Study.","authors":"Dania Johnson, Andrew Humbert, Kimberly Roaten, Shelley Wiechman, Jeffrey C Schneider, Haig A Yenikomshian","doi":"10.1093/jbcr/iraf070","DOIUrl":"https://doi.org/10.1093/jbcr/iraf070","url":null,"abstract":"<p><p>Burn injuries impact both functional and psychosocial quality of life. Genital burns may uniquely affect anatomy, sensation, self-perception, yet research remains limited. This study explores the impact of genital burns on body image, sexual satisfaction, and health-related quality of life. This retrospective analysis included adults (≥18 years) from 2016-2024 in a multicenter longitudinal patient-reported outcome database. Linear mixed-effect models evaluated the impact of genital burns on Patient-Reported Outcome Measurement Information System (PROMIS-29) outcomes (anxiety, depression, fatigue, pain, function, sleep, sexual satisfaction) and Burn Specific Health Scale (BSHS) body image at 6, 12, and 24 months, adjusting for demographics, total burn size, and time. Interaction terms assessed differences in recovery trajectories. Of 4,594 participants, 649 had genital burns and 3,945 did not. After adjustment, no significant differences were observed in baseline PROMIS-29 or BSHS outcomes. Longitudinal analyses revealed significant differences in recovery trajectories for depression, sleep disturbance, and body image. At 24 months, participants with genital burns had increased depression scores (+1.22) compared to a reduction (-0.60) in those without (p = 0.036). Sleep disturbance improvements at 12 months were smaller for those with genital burns (0.9 vs. 1.88-point reduction, p = 0.042). Body image scores declined for participants with genital burns, while improving for those without, with significant differences at 12 months (p = 0.026) and 24 months (p = 0.001). No significant differences were observed for anxiety, fatigue, pain interference, physical function, or sexual satisfaction. Genital burns significantly impact recovery, particularly depression, sleep, and body image.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypermetabolism exacerbation with increased white blood cell counts in patients with severe burns. 严重烧伤患者高代谢加剧伴白细胞计数增高。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-04 DOI: 10.1093/jbcr/iraf061
Beth A Shields, Alexis D Caponera, Jasmine D Geromiller, Julianne M Koenigsberg, James K Aden, Beatriz George, Leopoldo C Cancio
{"title":"Hypermetabolism exacerbation with increased white blood cell counts in patients with severe burns.","authors":"Beth A Shields, Alexis D Caponera, Jasmine D Geromiller, Julianne M Koenigsberg, James K Aden, Beatriz George, Leopoldo C Cancio","doi":"10.1093/jbcr/iraf061","DOIUrl":"https://doi.org/10.1093/jbcr/iraf061","url":null,"abstract":"<p><p>Severe weight loss after large burns has been previously described when the hypermetabolic response is not met with adequate nutritional provisions. Clinically, we have been able to minimize this weight loss in most patients admitted to our burn center but have identified unexpected weight loss in some. The goal of this analysis was to identify predictors of this weight loss. This retrospective descriptive study included adult patients with at least 20% TBSA burns admitted between September 2017 and February 2023. There were 63 patients who met the criteria for this study: median of 35% TBSA burn (IQR: 27-51), 44 years old (IQR: 31-55), 21% women. These patients experienced a median weight loss of 3 kg (IQR: 1-8) over 31 days (IQR: 22-50). Most (78%) patients experienced ≤10% weight loss, whereas 2% sustained >20% weight loss. The final factors significant in the multivariate analysis evaluating weight loss included days from injury to lowest weight, average WBC x days, and caloric deficit (p <0.01). The resulting equation is: weight loss (in kg) = 1.1 + 0.0121 x average WBC in 103/uL x days + 0.0001 x caloric deficit - 0.1432 x days from injury to lowest weight (R2=0.54). This indicates a further increase in metabolism above the expected hypermetabolic response when there is an elevation in WBC, likely reflecting concurrent sepsis or other processes driving systemic inflammation. Further research should focus on frequent metabolic cart study measurements in patients with elevated WBC counts to further elucidate this relationship.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burns with Intent: A Retrospective Analysis of Self-Inflicted Burn Injuries. 故意烧伤:自我造成烧伤的回顾性分析。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-04 DOI: 10.1093/jbcr/iraf074
Vishal Bandaru, Vivie Tran, Brandon Youssi, Coltyn Wagnon, Lauren Conkin, Rohan Pendse, Kaylen Meers, Alex Trindade, Chip Shaw, John Griswold, Alan Pang
{"title":"Burns with Intent: A Retrospective Analysis of Self-Inflicted Burn Injuries.","authors":"Vishal Bandaru, Vivie Tran, Brandon Youssi, Coltyn Wagnon, Lauren Conkin, Rohan Pendse, Kaylen Meers, Alex Trindade, Chip Shaw, John Griswold, Alan Pang","doi":"10.1093/jbcr/iraf074","DOIUrl":"https://doi.org/10.1093/jbcr/iraf074","url":null,"abstract":"<p><p>Self-inflicted burns (SIB) comprise a significant and yet minimally researched area within burn injuries and are often associated with complex psychiatric conditions, high morbidity and mortality. SIB are often associated with higher total body surface area (TBSA) burns, inhalational injuries, and length of stay. This study seeks to investigate the demographics, clinical outcomes, and psychiatric comorbidities of SIB patients treated at a tertiary care burn center between 2011 and 2021. We analyzed a total of 49 SIB and 28 assault burns out of 1293 total burn patients. Findings revealed that adult SIB, assault burns, and non-intentional burns in our region primarily affects white middle-aged men, but minority ethnic groups were afflicted at a higher rate in the intentional burn groups. The difference between the non-intentional and SIB group was significant for some burn severity and outcome variables: total TBSA, second-degree burn, third-degree burn, length of stay, facial burn, inhalation injury and mortality when not compared with other variables. total TBSA, second-degree TBSA, third-degree TBSA and inhalation injury were found to be associated with intentionality, but neither of the outcome variables were found to be correlated when analyzed with other variables. The following past medical history and history of present illness correlated as well: history of mental illness, history of drug abuse, history of self-harm, history of mental hospitalization, history of self-harm hospitalization, history of abuse, history of burn hospitalization, and burn symmetry. The probability of SIB was well modeled by a function of total TBSA and presence of a history of drug abuse. An analysis of psychiatric ailments revealed that patients with certain medical conditions had significantly higher odds of having committed a self-inflicted burn injury - depression was 9 times more likely, acute schizophrenia was 10 times more likely, and borderline personality disorder was 25 times more likely. Most self-inflicted burns were suicide attempts (67%) with the most common known etiology being gasoline (35%) and most common prior life event was a dispute with another person (27%). While self-inflicted burns constitute a small number of patients in the hospital, the proportional mortality is greater due to the frequency of SIB patients with larger burn injury. Our findings demonstrate that while LOS and mortality occur at a higher rate, that these variables are not indicators of SIB. As burn care continues to improve, the steps to decrease morbidity and mortality of burn care may need to shift to preventative measures and collaboration with municipal districts to identify and diffuse high-risk patients prior to an SIB occurring.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Home Oxygen Safety in an Urban Population: A Multi-Pronged Approach. 城市人口家庭氧气安全:多管齐下的方法。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-04 DOI: 10.1093/jbcr/iraf076
Wanda Horn, Janice Korenblatt, Elizabeth A Duthie, Lauren Huber, Iby Thomas, Daniel G Fein, Amy R Ehrlich
{"title":"Home Oxygen Safety in an Urban Population: A Multi-Pronged Approach.","authors":"Wanda Horn, Janice Korenblatt, Elizabeth A Duthie, Lauren Huber, Iby Thomas, Daniel G Fein, Amy R Ehrlich","doi":"10.1093/jbcr/iraf076","DOIUrl":"https://doi.org/10.1093/jbcr/iraf076","url":null,"abstract":"<p><p>Home oxygen improves the survival of patients with severe chronic hypoxic lung disease, but is associated with an increased risk of burns, fires, and fatalities. There is minimal data about potential risk factors for fires and burns in an urban population discharged from the hospital to the community on oxygen. This is a 7-year retrospective chart review of patients discharged on oxygen to a Certified Home Health Agency. The highest-risk patients were defined as those believed by a nurse to be at imminent danger of causing a burn or fire and requiring review by an Emergency Committee; these are analyzed in more detail. A total of 1,301 patients were discharged on home oxygen. Twenty-six patients were identified as highest- risk and required emergency interventions. Risk factors for burns and fires included: 85% active smokers, 46% substance use disorder, 19 % unstable psychiatric disease or an unreliable caregiver. The primary care physician in the community was unaware that the patient had oxygen in the home in 35% of these cases. A Home Oxygen Safety Committee was convened to address improvements in the Electronic Health Record (EHR), hospital infrastructure, and patient and caregiver education to improve home oxygen safety. Burns and fires related to home oxygen are rare events but can be devastating to the patient, caregivers, and community. Establishing a regulatory requirement that oxygen be included on the medication list at hospital discharge, and in the ambulatory setting, has the potential to improve transitions of care for this vulnerable population.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A proof-of-concept for a continuous-temperature circulating water bath in frostbite limb rewarming. 冻伤肢体复温中连续温度循环水浴的概念验证。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-04 DOI: 10.1093/jbcr/iraf073
Robert McKenzie, Zoë Anderson, Sebastian Kilcommons, Joshua N Wong, Alexis Armour
{"title":"A proof-of-concept for a continuous-temperature circulating water bath in frostbite limb rewarming.","authors":"Robert McKenzie, Zoë Anderson, Sebastian Kilcommons, Joshua N Wong, Alexis Armour","doi":"10.1093/jbcr/iraf073","DOIUrl":"https://doi.org/10.1093/jbcr/iraf073","url":null,"abstract":"<p><p>Frostbite is a thermal tissue injury that can occur following prolonged exposure to freezing temperatures, often resulting in tissue ischemia and sometimes requiring amputation. The American Burn Association recommends rapid rewarming of frostbite injuries in 38-42℃ water for 15-30 minutes, but clinical application of this recommendation is often inconsistent. Our objective was to find a method to better facilitate frostbite treatment by creating a continuous-temperature circulating water bath and demonstrating its effectiveness with a proof-of-concept, descriptive study. We hypothesized that this design would effectively rewarm chilled extremities within 30 minutes without healthcare workers being required to continually monitor and maintain water temperature. We constructed a continuous-temperature circulating water bath system using a reservoir and an Anova Precision Cooker NANO. Pig feet were chilled and then immersed in 39.0℃ water with or without the Anova Precision Cooker NANO. Without the Anova Precision Cooker NANO, tissue warmed from 3.2 ± 0.3℃ to 34.2 ± 0.2℃ over 30 minutes (final water temperature of 36.5 ± 0.1℃). With it, tissue warmed from 2.7 ± 0.2℃ to 36.7 ± 0.2℃ (final water temperature of 39.1 ± 0.1℃). The continuous-temperature circulating water bath offers a standardized, reliable, and effective method for rewarming hypothermic tissue. Our approach could provide a solution to inconsistent and impractical frostbite rewarming methods in clinical settings to better promote rewarming compliance. Further studies are ongoing to validate the feasibility of using the continuous-temperature circulating water bath in clinical practice.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to assess scar quality in pediatric burn patients: a systematic review on the type and content of outcome measurement instruments. 如何评估儿童烧伤患者的疤痕质量:对结果测量仪器的类型和内容的系统回顾。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-03 DOI: 10.1093/jbcr/iraf048
Frederique M Kemme, Adinda Mieras, Johannes C F Ket, Annebeth Meij-de Vries, Paul P M van Zuijlen, Anouk Pijpe
{"title":"How to assess scar quality in pediatric burn patients: a systematic review on the type and content of outcome measurement instruments.","authors":"Frederique M Kemme, Adinda Mieras, Johannes C F Ket, Annebeth Meij-de Vries, Paul P M van Zuijlen, Anouk Pijpe","doi":"10.1093/jbcr/iraf048","DOIUrl":"https://doi.org/10.1093/jbcr/iraf048","url":null,"abstract":"<p><p>Measuring scar quality is important for monitoring scar development and evaluating treatment outcomes. Given the substantial representation of children within the burn population and their susceptibility to lifelong scarring, evaluating scar quality is particularly important in this group. This study provides an overview of outcome measurement instruments used to assess scar quality in pediatric burn patients. A systematic literature search was conducted in PubMed, EMBASE and Web of Science covering studies published up to March 25, 2024. We included original research studies in English that measured at least one scar quality characteristic in pediatric burn patients. We included 328 studies and identified 585 outcome measurement instruments: clinician-reported outcome measures (CROMs) (53%), measurement devices (25%), and patient-reported outcome measures (PROMs) (22%). The most frequently used instruments were the (modified) Vancouver Scar Scale (m)(VSS), ultrasound, and the Patient and Observer Scar Assessment Scale (POSAS) Patient scale, respectively. Thickness and itch were the most frequently assessed scar characteristics. The use of PROMs has increased over the past decade, particularly after 2016, highlighting their growing attention. Among the studies using PROMs, 42% reported age-related conditions, with thresholds for independent completion ranging from 5 to 16 years. However, CROMs are the most frequently used instruments. While PROMs, CROMs and measurement devices are valuable, they are often not specifically designed for or validated in pediatric burn patients, and therefore they could benefit from further development or validation to better address the specific needs of pediatric burn patients.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Impacting Delayed Return to School Among Children Living with Burn Injury: A Burn Model System Study. 影响烧伤儿童延迟返校的因素:一项烧伤模型系统研究。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-02 DOI: 10.1093/jbcr/iraf059
Geun-Woo Oh, Gretchen J Carrougher, Xinyao deGrauw, Rachel Field, Stephanie Lillybridge, Caitlin M Orton, Deja Nicholas, Carly Marincasiu, Shelley A Wiechman, Sarah Stoycos, Karen Kowalske, Colleen M Ryan, Barclay T Stewart
{"title":"Factors Impacting Delayed Return to School Among Children Living with Burn Injury: A Burn Model System Study.","authors":"Geun-Woo Oh, Gretchen J Carrougher, Xinyao deGrauw, Rachel Field, Stephanie Lillybridge, Caitlin M Orton, Deja Nicholas, Carly Marincasiu, Shelley A Wiechman, Sarah Stoycos, Karen Kowalske, Colleen M Ryan, Barclay T Stewart","doi":"10.1093/jbcr/iraf059","DOIUrl":"https://doi.org/10.1093/jbcr/iraf059","url":null,"abstract":"<p><p>Return to school is a key indicator of rehabilitation effectiveness for school-age children with burn injury. Previous studies reported on the timing of return to school but have not delineated how individual and injury characteristics impact RTS due to single-center analyses and limited sample sizes. Our goal is to provide factors to consider when providing guidance and benchmarking days to RTS and allocating rehabilitation resources after burn injury. We analyzed data from a multicenter, longitudinal cohort study of US school-age children between the ages 5-17 years who required operation for wound closure and their parents/guardians. Days from index hospital discharge to return to school by self- or parent/guardian-report were recorded via surveys. The associations between days to return to school and age, sex, burn size, body region of injury, inhalation injury, number of operations, and month of discharge were examined using multivariable mixed-effects Poisson regression analyses with robust standard error estimates. Data from 266 participants were analyzed. The median days to return to school after hospital discharge were 43 (IQR 21.5-81 days). Days to return to school after discharge in school-age children with burn injuries were significantly longer among 12-14-year-olds, boys, and children who fire/flame injury had had ≥ 5% TBSA, inhalation injury, head/neck injury, more operations, and were discharged during the school year months. Future research should explore children's experiences with barriers in school settings and develop mitigation strategies addressing both clinical and non-clinical aspects of burn aftercare to enhance care for children with burn injuries.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the scalpel blade as an objective tool for measuring dermatome cut thickness. 评估手术刀刀片作为测量皮肤切割厚度的客观工具。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-05-02 DOI: 10.1093/jbcr/iraf067
Dallan P Dargan, Lawrence J Gottlieb, Sebastian Q Vrouwe
{"title":"Assessment of the scalpel blade as an objective tool for measuring dermatome cut thickness.","authors":"Dallan P Dargan, Lawrence J Gottlieb, Sebastian Q Vrouwe","doi":"10.1093/jbcr/iraf067","DOIUrl":"https://doi.org/10.1093/jbcr/iraf067","url":null,"abstract":"<p><p>Dermatomes are widely used for split thickness skin graft harvest. The graft thickness depends in part on the cut thickness setting, adjusted by the surgeon using a lever on the dermatome. This study aimed to assess whether a #15 scalpel blade placed in the dermatome blade aperture may reliably confirm the cut thickness setting (the scalpel dermatome test). Discrepancies between the blade-measured aperture and the cut thickness setting and the intra- and interobserver reliability of the technique were evaluated. The thickness of ten #15 blades (n=10) was measured using a micrometer. Six dermatomes were each assessed by two surgeons in triplicate each for the narrowest cut thickness setting that would permit passage of an entire surgical blade through the dermatome blade aperture, starting at zero and increasing cut thickness intervals of 1/1000 in. The mean scalpel blade thickness was 0.391 mm (~15/1000 in). The mean cut thickness setting which would permit the blade was 6/1000 in (range 2-9), p<0.001. Intra-observer reliability was good (intra-class correlation coefficient 0.89). Inter-observer reliability was moderate (intra-class correlation coefficient 0.52) and a mean difference of 1.5/1000 in was observed (6.8 versus 5.2, t-test p<0.018). Individual dermatome apertures differed, with the mean of three measurements for each ranging from 5.0 to 7.8/1000 in, p<0.001. Differences exist between scalpel blades, dermatomes and surgeons, however intra-observer reliability is good. The test is a simple maneuver, which can objectively validate the dermatome blade aperture, thereby preventing harm and optimising graft thickness.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silver Sulfadiazine and Boric Acid are Effective in Protecting the Stasis Zone from Secondary Ischemia. 磺胺嘧啶银和硼酸对继发性缺血瘀滞区有保护作用。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-04-30 DOI: 10.1093/jbcr/iraf068
Muhammed Salih Süer, Ömer Cennet, Mehmet Ülkir, Elham Bahador Zirh, Ayşegül Fırat, Ali Konan
{"title":"Silver Sulfadiazine and Boric Acid are Effective in Protecting the Stasis Zone from Secondary Ischemia.","authors":"Muhammed Salih Süer, Ömer Cennet, Mehmet Ülkir, Elham Bahador Zirh, Ayşegül Fırat, Ali Konan","doi":"10.1093/jbcr/iraf068","DOIUrl":"https://doi.org/10.1093/jbcr/iraf068","url":null,"abstract":"<p><p>A burn wound is characterized by hyperemia on the outer layer, stasis in the middle zone, and coagulation zones in the innermost region due to thermal damage to the skin. It is crucial to provide prompt and adequate treatment to prevent further damage. The depth of the burn increases as ischemic indicators become more distinct in the stasis zone when the burn is not adequately treated, despite the absence of ischemic signs in the stasis zone at the initial stages of the wound. This study aims to assess the impact of silver sulfadiazine, boric acid, low molecular weight heparin, and glyceryl trinitrate on wound healing in the stasis zone. The study involved four intervention groups, each consisting of six rats, and a sham group. After seven days of daily topical application of the active substances, the animals were sacrificed, and wound healing in the stasis zones was evaluated through macroscopic, histological, and immunohistochemical analysis. These findings demonstrate the effectiveness of these treatments in promoting wound healing. The results demonstrated that the boric acid and silver sulfadiazine groups exhibited the highest levels of wound healing, both macroscopically and histologically. Immunohistochemistry revealed significant differences, with the silver sulfadiazine group demonstrating superior results in MMP9 staining and the boric acid group in VEGF staining (p < 0.05). These findings suggest that boric acid and silver sulfadiazine effectively prevent ischemia in the stasis zone. Boric acid, in particular, appears to have significant potential as a wound healing agent due to its anti-inflammatory properties.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marijuana Use in a Nationwide Survey of Burn Survivors. 大麻在全国烧伤幸存者调查中的使用。
IF 1.5 4区 医学
Journal of Burn Care & Research Pub Date : 2025-04-28 DOI: 10.1093/jbcr/iraf064
Ana M Reyes, Walter A Ramsey, Christopher F O'Neil, Michael D Cobler-Lichter, Mary Ishii, Shevonne S Satahoo, Joyce I Kaufman, Louis R Pizano, Tulay Koru-Sengul, Jose Szapocznik, Carl I Schulman
{"title":"Marijuana Use in a Nationwide Survey of Burn Survivors.","authors":"Ana M Reyes, Walter A Ramsey, Christopher F O'Neil, Michael D Cobler-Lichter, Mary Ishii, Shevonne S Satahoo, Joyce I Kaufman, Louis R Pizano, Tulay Koru-Sengul, Jose Szapocznik, Carl I Schulman","doi":"10.1093/jbcr/iraf064","DOIUrl":"https://doi.org/10.1093/jbcr/iraf064","url":null,"abstract":"<p><p>There is growing interest in the role of marijuana and its derivatives in symptom management for chronic conditions including cancer and chronic pain. In burn survivors, marijuana use patterns are unknown. The objective of this study was to examine marijuana use in a nationwide sample of burn survivors. We hypothesized that severe symptoms or psychologic distress would be associated with marijuana use. Survivors were recruited and surveyed through the Phoenix Society for Burn Survivors from March to June 2023. The survey elicited demographics, burn characteristics, the continued impact of symptoms on quality of life, and therapies used for alleviating symptoms. Multivariable logistic regression was used to test for independent association of marijuana use with burn characteristics and symptoms. Of 178 respondents, the majority were female (59.6%), white (74.7%), ≥55 years old (51.1%), light skin toned (60.7%), >10 years removed from injury (52.8%), and had >20% total body surface area burns (75.3%). 41 survivors (23.0%) reported marijuana use. After controlling for confounding variables, having visible burns was associated with a 3.58 times increased odds of marijuana use compared to having hidden burns (95% CI 1.19-10.78). Being >10 years removed from burn injury (aOR 0.31, 95% CI 0.11-0.92) and having medium skin tone (aOR 0.32, 95% CI 0.11-0.96) were associated with reduced odds of marijuana use. On sensitivity analysis, no burn-related symptoms were consistently associated with marijuana use. In this nationwide survey, marijuana use was common and associated with visible burns. Understanding motivations for marijuana use and efficacy in this population require further study.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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