Journal of Cardiothoracic Surgery最新文献

{"title":"Anomalous hepatic vein drainage to the atrium following extracardiac total cavopulmonary connection: a case report and literature review.","authors":"Xuechen Liu, Junxiang Pan, Mengqian Liao, Tianhao Liao, Lianyi Wang, Yongqiang Jin","doi":"10.1186/s13019-025-03487-7","DOIUrl":"10.1186/s13019-025-03487-7","url":null,"abstract":"","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"253"},"PeriodicalIF":1.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the therapeutic potential of lncRNA FENDRR in DCM: novel targets and insights via the miR-296-5p/HMGA1 axis.","authors":"Lei Gu, Zunhai Zhou","doi":"10.1186/s13019-025-03477-9","DOIUrl":"10.1186/s13019-025-03477-9","url":null,"abstract":"<p><strong>Background: </strong>Long non-coding RNA (lncRNA) holds considerable promise in mitigating the onset and progression of diabetic cardiomyopathy (DCM). FENDRR was selected due to its reported involvement in cardiac apoptosis and inflammatory regulation, key pathways in DCM pathogenesis. This study investigated role and underlying mechanisms of FENDRR in DCM.</p><p><strong>Methods: </strong>Type 2 diabetes mellitus (T2DM) patients were included and stratified by DCM status. One group was T2DM patients without DCM (n = 49), and the other was T2DM patients with DCM (n = 47).. Clinical data from both groups were compared. qRT-PCR was utilized to quantify serum FENDRR expression, with ROC analysis assessing its diagnostic value. A DCM cell model was established using high glucose-treated H9c2 cells. Flow cytometry and ELISA assays measured apoptosis, myocardial enzyme levels, antioxidant enzyme levels, and inflammatory. Dual-luciferase assays confirmed FENDRR-miR-296-5p and miR-296-5p-HMGA1 interactions.</p><p><strong>Results: </strong>FENDRR was upregulated in DCM patients and high glucose-treated H9c2s (AUC = 0.888). si-FENDRR mitigated apoptosis in high glucose-stimulated H9c2 cells by inhibiting Bax and promoting Bcl-2 expression. si-FENDRR reduced myocardial enzymes release and inflammatory, and restored antioxidant enzyme levels. miR-296-5p was validated as a target of FENDRR, exhibiting an expression pattern opposite to that of FENDRR. miR-296-5p knockdown negated the positive effects of si-FENDRR on cardiomyocytes. HMGA1, a target gene of miR-296-5p, was upregulated in DCM patients and high glucose environments.</p><p><strong>Conclusions: </strong>This preliminary study uncovers the potential diagnostic value of FENDRR in DCM and explores its molecular mechanisms regulating myocardial cell injury via the miR-296-5p/HMGA1 axis.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"254"},"PeriodicalIF":1.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Race-over time: a critical case of acute myocardial infarction and ventricular tachycardia following blunt chest trauma.","authors":"Kun Lin, Chao Qin, Tao He","doi":"10.1186/s13019-025-03470-2","DOIUrl":"10.1186/s13019-025-03470-2","url":null,"abstract":"<p><strong>Introduction: </strong>Blunt chest trauma resulting in cardiac injury is a significant cause of mortality in trauma patients. Among the most critical sequelae, acute myocardial infarction (AMI) and ventricular tachycardia (VT) require prompt medical attention because of their potentially life-threatening nature. This case report examines the clinical progression and therapeutic approach in a patient who presented with these severe cardiac complications.</p><p><strong>Case presentation: </strong>A 42-year-old male was admitted with significant sternal pain, acute respiratory compromise, and substantial hemorrhage from cranial and facial injuries following a traumatic event. Initial clinical evaluation revealed elevated cardiac biomarkers and electrocardiographic abnormalities, resulting in the diagnosis of acute myocardial infarction (AMI) complicated by ventricular tachycardia (VT).</p><p><strong>Conclusion: </strong>This investigation underscores the paramount importance of expeditious diagnosis and intervention for acute myocardial infarction (AMI) and ventricular tachycardia (VT) in patients with blunt chest trauma. These findings demonstrate that even with comprehensive therapeutic intervention, severe cardiac complications may result in adverse outcomes.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"251"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined pathogenic characteristics to analyze susceptibility factors of postoperative pneumonia in patients undergoing cardiac surgery.","authors":"Jie Li, Zhenhua Wu, Chang Xie, Zhigang Guo","doi":"10.1186/s13019-025-03472-0","DOIUrl":"10.1186/s13019-025-03472-0","url":null,"abstract":"<p><p>Postoperative infection prevention is crucial for cardiac surgery patients. This study enrolled 579 cardiac surgery patients from November 2021 to July 2022, reporting a 12.3% incidence of postoperative pneumonia. Blood sugar, Montreal Cognitive Assessment (MoCA) scores, respiratory failure, and complications were linked to respiratory infections. Significant differences in biomarkers, including creatine kinase, urine volume, alanine transaminase (ALT), hemoglobin, and PaO2/FiO2, were observed between pneumonia types. Bacterial pneumonia cases showed positive correlations between ALT, urine volume, and infection, while hemoglobin and PaO2/FiO2 correlated negatively. The most common pathogens were Klebsiella pneumoniae (20.3%), Acinetobacter baumannii (11.6%), and Pseudomonas aeruginosa (10.9%). Identifying susceptibility factors and pathogenic characteristics can guide effective prevention strategies. Monitoring and oxygen therapy remain essential for reducing postoperative pneumonia risk in cardiac surgery patients.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"252"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease.","authors":"Ping Ni, Liming Dai, Hai Li, Jun Sun, Yicheng Zhu, Xiaolei Lv","doi":"10.1186/s13019-025-03490-y","DOIUrl":"10.1186/s13019-025-03490-y","url":null,"abstract":"<p><strong>Background: </strong>Coronary heart disease (CHD) is a chronic inflammatory disease carrying high morbidity and mortality. Interleukin (IL)-29 may be used as a biomarker for autoimmune diseases. This paper investigates the diagnostic value of serum IL-29 in CHD patients.</p><p><strong>Methods: </strong>A total of 90 CHD patients (39 mild and 51 severe patients) and 90 controls were included. Serum IL-29 levels were detected by ELISA, and the diagnostic value of IL-29 in CHD was analyzed by ROC curve. According to the median value of serum IL-29 level, CHD patients were categorized into IL-29 low-level group and high-level group. The correlation between IL-29 and pathological indexes of CHD patients was analyzed by chi-square test. SYNTAX score was used to classify CHD patients into mild CHD and moderate/severe CHD. Pearson coefficient analyzed the correlation between IL-29 and CHD severity. Multivariate logistic regression analyzed the risk factors for CHD exacerbation.</p><p><strong>Results: </strong>IL-29 serum levels were elevated in CHD patients. The AUC for CHD diagnosis by serum IL-29 was 0.789 (65.6% sensitivity and 76.7% specificity). IL-29 was correlated with BMI, PHASE score, and CRP. IL-29 serum level was positively correlated with CHD severity. The AUC for differentiating mild and moderate/severe CHD patients by IL-29 level was 0.739 (70.6% sensitivity and 66.7% specificity). IL-29 was an independent risk factor for CHD exacerbation, and each one-unit increase in IL-29 increased the risk of exacerbation in CHD patients by 1.065-fold.</p><p><strong>Conclusion: </strong>IL-29 is highly expressed in CHD patients and has auxiliary diagnostic value for CHD.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"249"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the role of KLRD1 in coronary atherosclerosis: harnessing bioinformatics and machine learning to advance understanding.","authors":"Huan Liang, Xiao Liang, Man Zheng, Shoudong Wang","doi":"10.1186/s13019-025-03473-z","DOIUrl":"10.1186/s13019-025-03473-z","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerosis (AS) is increasingly recognized as a chronic inflammatory disease that significantly compromises vascular health and serves as a major contributor to cardiovascular diseases. KLRD1 is a gene that encodes a protein involved in the immune system, specifically in the function of natural killer (NK) cells.</p><p><strong>Methods: </strong>KLRD1 was identified as a focal point through an integrative analysis of DEGs across multiple datasets (GSE43292 and GSE9820) from the GEO database, aligned with immune-related gene sets from the ImmPort database. Advanced analytical tools, including Lasso regression and SVM-RFE, were employed to refine our gene selection. We further applied GSEA and GSVA to these gene sets, revealing significant enrichment in immune-related pathways. The relationship between KLRD1 expression and immune processes was examined using CIBERSORT and ESTIMATE algorithms to assess tumor microenvironment characteristics, suggesting increased immune cell infiltration associated with higher KLRD1 expression. Validation of these findings was conducted using data from the GSE9820 dataset.</p><p><strong>Results: </strong>Among 340 DEGs linked with KLRD1, 13 were identified as hub genes through LASSO and SVM-RFE analyses. Functional assays highlighted KLRD1's role in mononuclear cell differentiation, regulation of cell-cell adhesion, regulation of T cell activation. A Lollipop was created to display the expression patterns of Correlation Coefficient. T cells CD8, Plasma cells, Dendritic cells activated, T cells CD4 memory resting, T cells CD4 memory activated, T cells gamma delta.</p><p><strong>Conclusions: </strong>This research elucidates the complex relationship between KLRD1 and AS, underscoring its potential as a novel biomarker for diagnosing and monitoring the disease.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"248"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the impact of minimally invasive esophagectomy on quality of life and functional prognosis in patients with esophageal squamous cell carcinoma: A retrospective comparative study.","authors":"Bo Liu, Kebing Wang, Wei Wang, Si Ye","doi":"10.1186/s13019-025-03485-9","DOIUrl":"10.1186/s13019-025-03485-9","url":null,"abstract":"<p><strong>Background: </strong>Minimally invasive esophagectomy (MIE) has shown potential benefits in reducing postoperative complications and improving recovery for patients with esophageal squamous cell carcinoma (ESCC). This study aims to assess the effects of MIE on preoperative and postoperative quality of life and functional outcomes in ESCC patients.</p><p><strong>Methods: </strong>Clinical data from 57 ESCC patients who underwent MIE were retrospectively analyzed. Baseline characteristics, including age, gender, BMI, TNM stage, smoking history, alcohol consumption, comorbidities, tumor location, differentiation, and lymph node metastasis, were collected. Postoperative quality of life scores, nutritional status, and functional outcomes were assessed. Paired t-tests and chi-square tests were used to compare preoperative and postoperative variables, while correlation analysis was conducted to evaluate associations between functional outcomes and quality of life.</p><p><strong>Results: </strong>A total of 57 patients (41 males, 16 females; mean age: 67.61 ± 7.72 years) who underwent MIE were analyzed. Postoperative evaluation demonstrated significant improvements in quality of life scores across multiple dimensions, including physical symptoms (P = 0.006), emotional management (P = 0.013), role function (P = 0.013), cognitive function (P = 0.042), and social function (P = 0.021). Additionally, nutritional status improved postoperatively, with higher albumin levels (4.12 ± 0.34 g/dL vs. 3.78 ± 0.25 g/dL, P < 0.001) and reduced weight loss (1.98 ± 1.02 kg vs. 2.44 ± 1.12 kg, P = 0.026). Functional outcomes also showed significant improvements, including decreased dysphagia scores (3.45 ± 1.56 vs. 4.04 ± 0.31, P = 0.008), while cardiac physical activity and respiratory function remained stable (P > 0.05). Correlation analysis indicated significant associations between specific functional outcomes and quality of life (P < 0.05).</p><p><strong>Conclusion: </strong>MIE improves quality of life, nutritional status, and functional outcomes in patients with esophageal squamous cell carcinoma, highlighting its potential benefits in postoperative recovery and patient well-being.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"250"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of circ_0050908 in acute myocardial infarction (AMI) and its predictive value for AMI.","authors":"Quan Song, Li Fang, Zheyi Rong, Jingyi Yan, Junbo Wei, Jie Luan","doi":"10.1186/s13019-025-03478-8","DOIUrl":"10.1186/s13019-025-03478-8","url":null,"abstract":"<p><strong>Objective: </strong>Acute myocardial infarction (AMI) is a serious condition that significantly affects human health and is classified as an Acute Coronary Syndrome (ACS). Timely diagnosis of AMI is currently paramount for guiding its treatment. The objective of this research is to examine the influence of circ_0050908 in AMI and its potential as a predictive marker for the condition.</p><p><strong>Methods: </strong>The study included 110 patients with AMI, along with 82 healthy volunteers. The expression levels of circ_0050908 in the healthy control group, AMI patients, and AC16 cells were validated using the qRT-PCR method. The diagnostic value of circ_0050908 for AMI was assessed through binary logistic regression analysis and ROC curve analysis. An AMI cell model was constructed by subjecting AC16 cells to hypoxia-reoxygenation treatment. To assess cell viability and apoptosis, the researchers utilized the CCK-8 assay and flow cytometry techniques. The relationship between circ_0050908 and miR-338-3p was validated through dual-luciferase reporter assays and RNA immunoprecipitation (RIP) tests.</p><p><strong>Results: </strong>circ_0050908 was found to be significantly elevated in AMI patients, while the levels of its target, miR-338-3p, were significantly reduced. Furthermore, circ_0050908 demonstrated strong predictive ability for AMI. Silencing circ_0050908 showed protective effects against H/R-induced damage to myocardial cells, leading to enhanced cell survival and decreased inflammatory responses, along with decreased myocardial injury markers CK-MB and cTnT. However, transfection with miR-338-3p inhibitor suppressed these protective effects.</p><p><strong>Conclusion: </strong>This study indicated that circ_0050908 has potential value as a diagnostic biomarker for AMI and explored the function of the circ_0050908/miR-338-3p axis in the mechanism underlying AMI.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"247"},"PeriodicalIF":1.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of successful pulmonary valve-sparing repair in pediatric humanitarian patients with Tetralogy of Fallot.","authors":"Vitor Mendes, Abdelkhalek Mouloudi, Jalal Jolou, Tomasz Nalecz, Ana Abecasis, Telmo Pereira, Tornike Sologashvili","doi":"10.1186/s13019-025-03475-x","DOIUrl":"10.1186/s13019-025-03475-x","url":null,"abstract":"<p><strong>Introduction: </strong>The optimal surgical approach for right ventricular outflow tract obstruction in Tetralogy of Fallot aims to preserve the native pulmonary valve annulus, as this is associated with better long-term outcomes. Pediatric humanitarian patients often present with a delayed diagnosis and lack access to preoperative palliative treatments, reducing the likelihood of pulmonary valve annulus preservation and potentially compromising long-term outcomes. This study aims to identify independent predictors of successful pulmonary valve-sparing repair in pediatric humanitarian patients undergoing corrective surgery for Tetralogy of Fallot.</p><p><strong>Methods: </strong>Between January 2019 and May 2023, pediatric humanitarian patients with Tetralogy of Fallot underwent surgical correction at our center. We performed a comparative analysis of preoperative, intraoperative, and postoperative variables, followed by univariate and multivariate logistic regression to identify independent predictors of pulmonary valve-sparing repair.</p><p><strong>Results: </strong>A lower body mass index (OR = 0.711; p = 0.021; 95% CI = 0.533-0.949), a larger pulmonary valve annulus measured in centimeters (OR = 28.653; p = 0.008; 95% CI = 2.360-347.890) and a higher Z-score of pulmonary valve annulus (OR = 1.606; p = 0.023; 95% CI = 1.067-2.418) were identified as independent predictors of pulmonary valve-sparing repair.</p><p><strong>Conclusion: </strong>Successful pulmonary valve-sparing repair was associated with lower BMI and a larger pulmonary valve annulus (both measurements in centimeters and Z-score). These findings may help guide clinical and policy strategies to promote more equitable and effective surgical care in resource-limited settings.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"243"},"PeriodicalIF":1.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of diagnosis and treatment of mediastinal Langerhans cytosis.","authors":"Yumeng Niu, Lei Xian, Yi Wang, Yourong Chen, Yifei Lu, Daying Liang","doi":"10.1186/s13019-025-03489-5","DOIUrl":"10.1186/s13019-025-03489-5","url":null,"abstract":"<p><strong>Background: </strong>Langerhans cell histiocytosis (LCH) is a rare disease. It mainly involves abnormal proliferation and aggregation of Langerhans cells, a type of cell of the immune system.Langerhans cytosis is more common in the bone, but it has rarely been reported in the mediastinum.</p><p><strong>Case presentation: </strong>We present a case of mediastinal thymus tumor presented with Langerhans cell histiocytosis. A 40-year-old female patient presented with left chest and back pain in April 2024. Imaging revealed abnormal signal lesions on the patient's left rib and anterior superior mediastinum. The clinical diagnosis was bone destruction and mediastinal space occupation, and the postoperative pathological diagnosis was Langerhans cell histiocytosis.</p><p><strong>Conclusions: </strong>Langerhans cytosis is characterized by mediastinal and thymus occupation and is relatively rare in clinical practice. For patients who tolerate surgery for a single or local lesion, surgical removal of the primary lesion should be considered. However, for patients with multiple lesions or distant metastases, clinicians should evaluate whether surgery will benefit the patient. After surgical treatment, targeted therapy or immunotherapy should be performed.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"245"},"PeriodicalIF":1.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}