Journal of Cardiothoracic Surgery最新文献

{"title":"External validation of SYNTAX score II in a real-world cohort undergoing coronary artery bypass grafting.","authors":"Philipp Angleitner, Hannes Abfalterer, Alexandra Kaider, Emely Manville, Martin Bichler, Michael Graber, Leo Pölzl, Daniel Zimpfer, Sigrid Sandner, Nikolaos Bonaros","doi":"10.1186/s13019-025-03572-x","DOIUrl":"10.1186/s13019-025-03572-x","url":null,"abstract":"<p><strong>Background: </strong>Our aim was to evaluate SYNTAX Score II for its ability to predict mortality in all-comers undergoing isolated coronary artery bypass grafting.</p><p><strong>Methods: </strong>External validation of SYNTAX Score II was performed in a retrospective analysis of 2 tertiary care centers. Mortality at 4 years after surgery was defined as the primary outcome variable. External validation included assessment of calibration (calibration-in-the-large, observed-expected ratio, calibration slope) and discrimination (concordance statistic, Receiver Operating Characteristic curve). Additionally, SYNTAX Score II's performance was compared with the performance of EuroSCORE II, the logistic EuroSCORE, and ACEF Score.</p><p><strong>Results: </strong>The study cohort included 1454 patients (Medical University of Vienna, n = 782; Medical University of Innsbruck, n = 672). Kaplan-Meier survival curves showed that tertiles of SYNTAX Score II were significantly associated with mortality (log-rank test, p < 0.001). In a stratified multivariable Cox proportional-hazards regression model, the following score components were independently associated with mortality: age (hazard ratio 1.03, 95% confidence interval 1.00 to 1.06), creatinine clearance (hazard ratio 0.98, 95% confidence interval 0.97 to 0.99), left-ventricular ejection fraction (hazard ratio 0.97, 95% confidence interval 0.95 to 0.98), and chronic obstructive pulmonary disease (hazard ratio 2.02, 95% confidence interval 1.34 to 3.05). The anatomical SYNTAX Score was not independently associated with mortality (hazard ratio 1.00, 95% confidence interval 0.98 to 1.02). Assessment of SYNTAX Score II calibration revealed an observed-expected ratio of 0.61 and a calibration slope of 0.62 (p < 0.001 for comparison with slope = 1.0), indicating general overestimation of 4-year mortality. The c-statistic amounted to 0.73. Performance of SYNTAX Score II was comparable with the performance of EuroSCORE II (c-statistic 0.73), the logistic EuroSCORE (c-statistic 0.74) and ACEF Score (c-statistic 0.72).</p><p><strong>Conclusions: </strong>Our analysis shows that SYNTAX Score II has acceptable discriminative strength with respect to 4-year mortality in all-comers undergoing isolated coronary artery bypass grafting. Notably, mortality is over-estimated in patients with higher SYNTAX Score II values. SYNTAX Score II, EuroSCORE II, the logistic EuroSCORE, and ACEF Score offer comparable predictive value towards 4-year mortality.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"324"},"PeriodicalIF":1.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of outcomes post Cor-Knot versus Manual tying in valve surgery: our 8-year analysis of over 1000 patients.","authors":"Hiral Jhala, Keith Buchan, Hussein El-Shafei","doi":"10.1186/s13019-025-03419-5","DOIUrl":"10.1186/s13019-025-03419-5","url":null,"abstract":"<p><strong>Background: </strong>In the era of minimally invasive valve surgery (MIVS), automated titanium fasteners such as Cor Knot®, have reduced aortic-cross clamp (AXC) and cardiopulmonary bypass (CPB) times to improve survival outcomes. Whilst, most comparative studies pertain to MIVS, there is a lack of literature comparing Cor-Knot (CT) and manual knot tying (MT) in open valve procedures performed via full median sternotomy, particularly the long-term outcomes. We primarily compare AXC and CPB times, residual valvular regurgitation (RVR), freedom from valve re-intervention (FFI) and secondary post-operative outcomes of CT vs MT.</p><p><strong>Methods: </strong>Retrospective analysis was performed for all adult patients, undergoing any first-time or redo valve surgery ± concomitant procedure via full median sternotomy, at a single-centre between January 2017 and January 2024). Patients were grouped according to operation type: isolated aortic valve replacement (AVR), isolated mitral valve replacement (MVR), isolated mitral valve repair (MVr), double valve, valve and concomitant CABG, major aortic surgery and redo valve surgery. Patients within each procedural group were further subdivided into either CT or MT groups. RVR and FFT between CT and MT in each subgroup were analysed using the Kaplan-Meier method.</p><p><strong>Results: </strong>N = 1010 (CT: N = 492, MT: N = 518). Mean age was 67.7 years. AXC and CPB times were lower in the CT group (62.9 and 86.4 min) vs the MT group (74.9 and 100.1 min) in isolated aortic valve replacements (AVR)(p < 0.001). AXC and CPB times were also lower in the CT group (83.6 and 120.9 min) vs the MT group (103.7 and 143.3 min) in valve + CABG procedures (p < 0.001). The CT group had no RVR in isolated AVR or valve & CABG procedures, however a higher RVR in mitral valve surgery (p = 0.28), double valves (p = 0.49) and redo valves (p > 0.99) compared to the MT group. FFI at 7 years was 98.8% (MT) vs 94.1% (CT) (p = 0.02) in isolated AVR.</p><p><strong>Conclusion: </strong>Cor-knot can safely and easily be used in all valve procedures. Intra-operative and cinical outcomes with CorKnot can be correlated better in AVR however the short and long-term benefits of CorKnot following mitral surgery are limited. Further larger studies, particularly in more complex procedural groups and long-term analyses are warranted to further validate our results.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"323"},"PeriodicalIF":1.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage bibliometric study and visualization in myocardial ischemia-reperfusion.","authors":"Zhenhao Li, Baocheng Pei, Jun Ma, Yuxiang Zhu, Zhongdong Sun","doi":"10.1186/s13019-025-03563-y","DOIUrl":"10.1186/s13019-025-03563-y","url":null,"abstract":"<p><strong>Purpose: </strong>Restoration of blood flow after tissue ischemia aggravates the injury, a phenomenon known as ischemia-reperfusion injury. And ischemia-reperfusion injury of myocardium becomes a common cause of death after surgery in many patients. Relevant studies have proved that ischemia-reperfusion of myocardium has a strong correlation with autophagy, macrophage, endoplasmic reticulum, etc. Therefore, this paper systematically summarises and discusses the macrophage research in myocardial ischemia-reperfusion injury through visual research and metrological analysis, hoping to point out the direction for the researcher in this field.</p><p><strong>Methods: </strong>We conducted a comprehensive search of publications on myocardial IRI and macrophages in the Web of Science Core Collection (WoSCC) database, covering the period from 2008 to June 2024. Bibliometric tools (CiteSpace, VOSviewer, and Excel) were used to analyze various factors such as publication trends, countries, institutions, journals, authors, and keywords. Visual maps were created to identify current research hotspots and forecast future developments in the field.</p><p><strong>Results: </strong>For this study we included a total of 1039 relevant studies, with a dynamic upward trend in the number of publications. China and the United States are in the top two in terms of the number of publications. The institution with the most publications is Fudan University, and the one with the most collaborations is the Chinese Academy of Medical Sciences. We also obtained the most publications with the highest number of citations and the highest impact factor. Inflammatory processes, mitochondrial autophagy, endoplasmic reticulum stress, and macrophages are current hotspots. Exploring molecular proteins and effective strategies to inhibit myocardial I/R injury may become the focus of future research.</p><p><strong>Conclusion: </strong>Macrophages have emerged as a key area of focus in myocardial IRI research in recent years. This is the first bibliometric study to comprehensively analyze the research landscape on macrophages and myocardial IRI, providing valuable insights for researchers and guiding future developments in the field.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"322"},"PeriodicalIF":1.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Comparing the effects of ketorolac and Paracetamol on postoperative pain relief after coronary artery bypass graft surgery. a randomized clinical trial.","authors":"Fatemeh Javaherforooshzadeh, Hasan Abdalbeygi, Farahzad Janatmakan, Behnam Gholizadeh","doi":"10.1186/s13019-025-03524-5","DOIUrl":"10.1186/s13019-025-03524-5","url":null,"abstract":"","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"321"},"PeriodicalIF":1.5,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge domains and hotspots in corticosteroid use for cardiac surgery: a 23-Year bibliometric and visualized analysis.","authors":"Wan-Wan Zou, Qi-Kun Zhu, Song Yang, En-Ze Bian, Wei-Zhong Zhuang, Jian-Zheng Cen, Qiang Gao","doi":"10.1186/s13019-025-03552-1","DOIUrl":"10.1186/s13019-025-03552-1","url":null,"abstract":"<p><strong>Background: </strong>The safety and efficacy of prophylactic corticosteroid administration during the perioperative period of cardiac surgery have undergone extensive and comprehensive examination. In this study, we conducted a bibliometric analysis of publications addressing corticosteroid use in the perioperative period of cardiac surgery, aiming to elucidate the principal research trajectories and emerging trends spanning the past 23 years.</p><p><strong>Methods: </strong>We performed a search in the Web of Science Core Collection for publications related to the application of corticosteroids during the perioperative period of cardiac surgery, spanning from the year 2000 to October 30, 2023. Bibliometric analysis was conducted employing the biblioshiny package in R, VOSviewer, and CiteSpace.</p><p><strong>Results: </strong>We identified 293 eligible publications concerning corticosteroid use during the perioperative period of cardiac surgery. Publication volume increased significantly in 2001 and 2014. Keyword co-occurrence analysis revealed four primary clusters: cardiopulmonary bypass, systemic inflammatory response, methylprednisolone, and dysfunction. Over recent decades, research focus has shifted from examining how prophylactic corticosteroid use attenuates postoperative inflammation to investigating its potential effects on clinical complications following cardiac surgery.</p><p><strong>Conclusions: </strong>Considerable heterogeneity in inflammatory response phenotypes among individuals may lead to significant differences in the clinical effectiveness of prophylactic corticosteroid interventions. Thus, developing personalized treatment strategies should become a major focus in future research.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"320"},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of multivessel disease patients after off-pump minimally invasive coronary surgery.","authors":"Lixue Zhang, Qing Gao, Simeng Zhang, Gang Liu, Bo Lian, Yu Chen, Yi Shi","doi":"10.1186/s13019-025-03557-w","DOIUrl":"10.1186/s13019-025-03557-w","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the safety and feasibility of minimally invasive coronary surgery (MICS) for patients with multivessel disease.</p><p><strong>Methods: </strong>Patients with multivessel coronary artery disease (CAD) undergoing isolated off-pump coronary artery bypass grafting surgery (OPCAB) in our center between January 2017 and December 2020 were included in this study. Patients were divided into the MICS group or the conventional OPCAB group. Clinical characteristics, surgical data, postoperative outcomes and graft patency were analyzed between the two groups. Propensity score matching (PSM) was performed to reduce the potential effects of a selection bias.</p><p><strong>Results: </strong>A total of 476 patients were included in this study, with 103 patients in the MICS group and 373 patients in the OPCAB group. Before matching, patients in the MICS group showed a higher left ventricular ejection fraction (LVEF) and a lower left ventricular end-diastolic dimension (LVEDD), and the proportion of patients with 3 target vessels or more was significantly lower in the MICS group. Following the PSM, bilateral internal thoracic arteries (ITAs), sequential grafting and composite conduits were more frequently used in the MICS group, and the proportion of patients with 2 anastomoses or more on the ascending aorta was significantly lower in the MICS group. The postoperative length of stay was significantly shorter in the MICS group, and the rate of wound dehiscence was lower in the MICS group. There was no difference in the rate of postoperative MI, stroke, repeated revascularization, or in-hospital death between the two groups. The short-term graft patency was similar between the two groups.</p><p><strong>Conclusions: </strong>MICS can achieve comparable clinical outcomes and graft patency to conventional OPCAB. Cardiac function and the number of target vessels are two factors that surgeons take in consideration when deciding to proceed with a MICS. Sequential grafts and composite conduits are more frequently used in MICS patients, which is in accordance with the reduction in the number of proximal anastomoses performed on the ascending aorta.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"318"},"PeriodicalIF":1.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective observational study of tetralogy of fallot with pulmonary atresia and ductal-dependent pulmonary circulation focusing on the staged transannular patch procedure: a single-center study.","authors":"Jae Hong Lee, Hyungtae Kim, Kwang Ho Choi, Si Chan Sung, Hyoung Doo Lee, Hoon Ko, Joung-Hee Byun, Tae Hong Kim, Mi Sook Yun","doi":"10.1186/s13019-025-03555-y","DOIUrl":"10.1186/s13019-025-03555-y","url":null,"abstract":"<p><strong>Background: </strong>Management of pulmonary atresia with ventricular septal defect and ductal-dependent pulmonary circulation (PA/VSD/PDA) varies according to pulmonary artery morphology and institutional surgical strategy. We adopted a range of initial palliative surgical options for patients with PA/VSD/PDA and evaluated the effectiveness of our management strategy.</p><p><strong>Methods: </strong>Twenty-five patients with PA/VSD/PDA were enrolled between May 2015 and July 2023. Patients with major aortopulmonary collateral arteries were excluded. The mean age at initial surgery was 14.9 ± 13.7 days, and the mean weight was 3.17 ± 0.35 kg. Twenty-two (88%) patients were neonates. Nineteen patients underwent initial palliative systemic-to-pulmonary shunt, while six underwent an initial definitive Rastelli operation depending on the main pulmonary artery morphology and branch pulmonary arteries size.</p><p><strong>Results: </strong>One patient died of postoperative brain hemorrhage following the initial definitive Rastelli operation. The mean follow-up duration was 58.5 ± 28.4 months. During follow-up, one patient died suddenly two months after the initial central shunt procedure. All surviving patients with a shunt, except two, underwent biventricular repair: ten with the Rastelli operation and six with the transannular patch (TAP) procedure. The staged TAP group demonstrated a significantly larger freedom from reoperation rate than that of the initial Rastelli operation group (p = 0.022) and a significantly lower catheter-based reintervention rate than that of the other two management groups (p = 0.011).</p><p><strong>Conclusions: </strong>A management strategy using an initial definitive Rastelli operation or systemic-to-pulmonary shunt based on main pulmonary artery development and branch pulmonary arteries size is safe and effective for PA/VSD/PDA treatment. The staged TAP procedure could be a viable option for patients with PA/VSD/PDA and a well-developed main pulmonary artery segment.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"319"},"PeriodicalIF":1.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of tricuspid and pulmonary regurgitation following surgical repair of subarterial ventricular septal defect via different approaches: predictors and outcomes.","authors":"Lai Li, Aijun Liu, Junwu Su","doi":"10.1186/s13019-025-03561-0","DOIUrl":"10.1186/s13019-025-03561-0","url":null,"abstract":"","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"317"},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NSUN2 inhibits NCOA4 expression to alleviate ferroptosis and inflammation in sepsis-induced myocardial injury in a m⁵C manner.","authors":"BaYinchahan BoRanyi, Xinwei Lv, Dong Xiao","doi":"10.1186/s13019-025-03554-z","DOIUrl":"10.1186/s13019-025-03554-z","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-induced myocardial injury (SIMI) leads to high morbidity and mortality. The 5-methylcytosine (m⁵C) RNA methyltransferase NOL1/NOP2/SUN domain (NSUN)2 is a therapeutic target for many diseases. The purpose of this study was to investigate the role of NSUN2 in SIMI and the potential mechanism.</p><p><strong>Methods: </strong>Both an in vivo cecum ligation and puncture (CLP) SIMI rat model and an in vitro lipopolysaccharide (LPS)-treated H9c2 cardiomyocytes model were established. Reverse transcription (RT)-quantitative polymerase chain reaction (qPCR) was used to detect m⁵C-related and ferroptosis-related mRNA levels. Enzyme-linked immunosorbent assay was performed to assess inflammatory cytokines levels. Ferroptosis-related indicators were detected by commercial kits and Western blot. Methylated RNA immunoprecipitation (MeRIP)-qPCR assay was performed to detect the m⁵C level of ferroptosis-related mRNAs. RIP assay was used to explore the interaction between NSUN2 and nuclear receptor coactivator (NCOA)4. The m⁵C site of NCOA4 was analyzed by dual-luciferase reporter assay.</p><p><strong>Results: </strong>NSUN2 alleviated LPS-induced SIMI by increasing cell viability and inhibiting inflammation and ferroptosis. In addition, NSUN2 inhibited NCOA4 expression in a m⁵C-dependent manner. Moreover, overexpressing NCOA4 downregulated cell viability and upregulated LDH activity, inflammation, and ferroptosis in LPS-induced SIMI. In in vivo studies, NSUN2 overexpression reversed CLP-induced myocardial injury, cardiac dysfunction, inflammation, and ferroptosis.</p><p><strong>Conclusions: </strong>NSUN2 inhibited NCOA4 expression to alleviate ferroptosis and inflammation in SIMI in a m⁵C manner, which might provide new information for the clinical treatment of SIMI.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"315"},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and advances in cardiac rehabilitation for congenital heart disease: a bibliometric analysis.","authors":"Haojie Zhou, Yuyang Huang, Weizhi Zhang, Hanyi Yao, Zhangqing Yi, Dongping Li","doi":"10.1186/s13019-025-03562-z","DOIUrl":"10.1186/s13019-025-03562-z","url":null,"abstract":"<p><strong>Background: </strong>Congenital heart disease (CHD) survivors often suffer from impaired health-related quality of life (HRQoL), requiring cardiac rehabilitation (CR) as an additional intervention. CR involves various modalities and has been demonstrated to reduce mortality and improve HRQoL in cardiovascular diseases. However, there is a lack of systematic analysis and summary of the accumulated literature on cardiac rehabilitation for congenital heart disease (CRfCHD). This study aimed to provide a comprehensive overview of the literature on cardiac rehabilitation for congenital heart disease. By analyzing research trends and hotspots, it also sought to highlight key developments and suggest future directions in this growing field.</p><p><strong>Methods: </strong>A systematic search of the Web of Science Core Collection was performed to identify publications related to CRfCHD. Bibliometric tools, including CiteSpace and VOSviewer, were used to visualize co-authorship networks, keyword clusters, and citation patterns.</p><p><strong>Results: </strong>A total of 218 articles were included in the analysis. The number of research papers on CRfCHD has shown an increasing trend over time, with a significant rise in publications since 2019. The United States has the highest number of publications, while the most cited paper focuses on the effects of physical exercise training in CHD patients. Keyword analysis reveals hotspots in the field such as congenital heart disease, physical activity, children, and adolescents.</p><p><strong>Conclusion: </strong>This bibliometric study analyzed the development of CRfCHD from 2003 to 2022, and overviewed the evolution and frontiers in this promising field. Future research should focus on developing comprehensive and effective CRfCHD programs. Home-based cardiac rehabilitation and mental health research in CHD patients require more attention.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"316"},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}