Journal of Cardiothoracic Surgery最新文献

{"title":"Construction and validation of a nomogram model for predicting the risk of recurrence in patients with lower extremity arteriosclerosis obliterans after surgical intervention.","authors":"Yanyan Lu, Lingyan Wang, Xiaoxiao Yu, Xiaohu Meng","doi":"10.1186/s13019-025-03413-x","DOIUrl":"https://doi.org/10.1186/s13019-025-03413-x","url":null,"abstract":"<p><strong>Objective: </strong>To explore and analyze the risk factors for recurrence in patients with lower extremity arteriosclerosis obliterans (ASO) after surgical intervention and to construct and validate a nomogram prediction model.</p><p><strong>Methods: </strong>A total of 270 patients with ASO treated at our hospital were retrospectively selected as study subjects and divided into a training cohort (189 cases) and a validation cohort (81 cases) based on a 7:3 ratio. Patients in the training cohort were further divided into recurrence and non-recurrence groups based on whether they experienced recurrence within two years post-surgery. Univariate and multivariate logistic regression analyses were employed to identify independent risk factors for postoperative recurrence, which were then used to construct a predictive model and generate a nomogram.</p><p><strong>Results: </strong>Of the 270 patients with ASO included in the study, the training cohort consisted of 189 patients, with 76 (40.21%) in the recurrence group and 113 (59.79%) in the non-recurrence group. The validation cohort consisted of 81 patients, with 32 (39.51%) in the recurrence group and 49 (60.49%) in the non-recurrence group. Univariate analysis in the training cohort revealed significant differences in age, body mass index (BMI), diabetes, hypertension, lesion location classification, use of antiplatelet drugs, triglycerides, fibrinogen (FIB), and di-dimer (D-D) (P < 0.05, respectively). Multivariate logistic regression analysis indicated that age ≥ 60 years, BMI ≥ 24 kg/m², diabetes, hypertension, discontinuation of antiplatelet therapy, FIB, and D-D were independent risk factors for recurrence after surgical intervention in patients with lower extremity ASO (OR = 2.471, 1.625, 4.568, 2.678, 5.974, 2.073 and 3.067; P < 0.05, respectively). When the training and validation cohorts were tested in the established nomogram model, the area under the curve (AUC) of the model was 0.832 (95% CI: 0.765-0.919) in the training cohort and 0.858 (95% CI: 0.745-0.964) in the validation cohort. Calibration curves indicated high consistency between the predicted and actual outcomes in both groups, suggesting good predictive accuracy of the model. Decision curve analysis showed that using this model significantly increased net clinical benefit for patients.</p><p><strong>Conclusion: </strong>The nomogram model constructed for predicting the risk of recurrence in patients with lower extremity ASO after surgical intervention demonstrates good predictive and discriminative abilities, offering valuable guidance for clinical screening of high-risk populations.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"203"},"PeriodicalIF":1.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of pregnancy in patients with pulmonary hypertension: A single center observational study.","authors":"Jianrong Pan, Qingsong Wu, Shixin Chen, Huilan Wang, Qimin Wang","doi":"10.1186/s13019-025-03435-5","DOIUrl":"https://doi.org/10.1186/s13019-025-03435-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pulmonary hypertension (PH) is associated with right ventricular failure in pregnant women and increases maternal morbidity and mortality during parturition and postpartum periods. According to current guidelines, pregnancy is contraindicated in women with PH. However, in recent decades, favorable outcomes have been observed in cases where the disease is well controlled. However, several questions remain unanswered regarding this issue.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to investigate the medium-term outcomes of pregnancy in women with PH and to identify predictors for poor pregnancy outcomes in this population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective review of the medical records at our hospital was conducted to identify pregnant women with PH between July 2017 and December 2021. We collected data on maternal age, gravidity, parity, PH category, New York Heart Association Function class, N-terminal-pro Brain natriuretic peptide (NT-ProBNP) levels, mode of delivery, type of anesthesia, use of advanced therapy, and fetal outcomes. Based on the severity of PH, patients were categorized into three groups: group A systolic pulmonary arterial pressure (SPAP) 40-50 mmHg, group B 50-70 mmHg, and group C SPAP ≥ 70 mmHg.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study included 78 individuals in group A, 22 in group B, and 18 in group C. Of the 118 individuals, 80 were classified as having pulmonary arterial hypertension (PAH), including congenital heart disease-associated PAH, idiopathic PAH, and other PAH subtypes, while 38 were classified as having PH associated with left heart disease (PH-LHD). The mortality rate was higher in the PAH category (6.3%, 5/80) than in the PH-LHD category (2.6%, 1/38). The NT-proBNP value was highest in group C (1723.5 ± 738.0pg/ml), compared with group B (196.6 ± 79.6 pg/ml) and group A (128.7 ± 54.3 pg/ml). Overall maternal mortality was 5.1% (6/118), with significantly higher mortality rates observed in group C (27.8%, 5/18) compared to group B (4.6%, 1/22), and no deaths in group A. Compared to groups A and B, gestational duration was shorter (median 26 weeks), and abortion rates were higher (38.9%, 7/18) in group C. Cesarean section rates were high across all three groups. The overall maternal mortality rate was 5.1% (6/118). Of them, five individuals were in group C, only one woman had moderate PH with perinatal cardiomyopathy and a lower LVEF of 15%. There was no maternal mortality in Group A with mild PH. All maternal deaths occurred postpartum. Excluding 17 cases of miscarriage (gestation less than 28 weeks), the overall offspring mortality rate was 4.0% (4/101), with one fetal mortality in group B, three fetal deaths in group C, and no fetal mortality observed in group A.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Severe PH and high NT-proBNP levels are strongly correlated with increased maternal mortality rates in pregnant women. Conception should be contraindicated in c","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"199"},"PeriodicalIF":1.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology-based prediction and molecular docking-based strategy to investigate the potential mechanism of Leonurus japonicus Houtt. Against myocardial ischemia reperfusion injury.","authors":"Xuan Liu, Zilian Zhan, Rui Zhang, Yadong Wang, Qiang Xu","doi":"10.1186/s13019-025-03425-7","DOIUrl":"https://doi.org/10.1186/s13019-025-03425-7","url":null,"abstract":"<p><strong>Background: </strong>Leonurus japonicus Houtt. (LJH) has multiple pharmacological effects.</p><p><strong>Objective: </strong>To investigate the potential mechanism of LJH in the treatment of myocardial ischemia-reperfusion injury (MIRI) using network pharmacology, molecular docking technology, and in vitro experiments.</p><p><strong>Methods: </strong>Herbs for ischemic heart disease were identified with the help of herb-disease databases. The TCMSP database was used to find the potential targets of LJH. Disease targets of MIRI were identified with the help of Disgenet, Genecard, Alliance of Genome Resources databases. The common targets were obtained with the help of VENN diagram, and the common targets were analyzed by GO function and KEEG pathway enrichment to predict the potential mechanism of action of LJH in treating MIRI. With the help of STRING database and Cytoscape software, we constructed a visual protein-protein interaction (PPI) network model to screen the core targets and then docked the core targets with the corresponding ligand molecules. AC16 cells were used to simulate MIRI by glucose-oxygen deprivation, and apoptosis was detected by Annexin V-FITC/PI double staining; protein expression was detected by Western blot.</p><p><strong>Results: </strong>LJH was one of the herbal remedies for the treatment of ischemic heart disease. LJH had 247 potential targets of action and 26 targets in common with MIRI. These 26 targets were enriched in the TNF signaling pathway and NF-kappa B signaling pathway, and the core targets screened by the PPI results included TNF, VCAM1, and MMP9. Molecular docking results showed that the compounds in LJH docked well with the core target proteins. In vitro experiments showed that LJH could inhibit the elevation of TNF, VCAM1, and MMP9 after MIRI, reduce apoptosis, and inhibit inflammation.</p><p><strong>Conclusion: </strong>The mechanism of LJH in the treatment of MIRI was mainly related to the activation of TNF signaling pathway and NF-kappa B signaling pathway, and the regulation of TNF, VCAM1, and MMP9 protein expression.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"204"},"PeriodicalIF":1.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel nomogram based on PET/CT to predict lymph nodal metastasis for lung adenocarcinoma with normal size lymph node.","authors":"Xinyu Zhu, Xinyu Jia, Shibing Teng, Kai Fu, Jiawei Chen, Jun Zhao, Chang Li","doi":"10.1186/s13019-025-03443-5","DOIUrl":"https://doi.org/10.1186/s13019-025-03443-5","url":null,"abstract":"<p><strong>Background: </strong>A precise assessment of lymph nodal status is essential for guiding an individualized treatment plan in lung adenocarcinoma patients. A novel nomogram using easily accessible indicators was developed and validated in this study to predict CT-negative lymph nodal metastasis.</p><p><strong>Methods: </strong>Between September 2020 and December 2023, data from 132 consecutive patients diagnosed with lung adenocarcinoma who underwent lung resection with systemic lymph node dissection or sampling were retrospectively reviewed. Risk factors associated with lymph nodal metastasis were identified using univariable and multivariable logistic regression analyses. Subsequently, a nomogram was developed on basis of these identified parameters. The performance and validity of the nomogram were evaluated using the area under the receiver operating characteristic (ROC) curve, calibration curve, and bootstrap resampling techniques.</p><p><strong>Results: </strong>Four predictors (primary tumor location, primary tumor SUVmax value, N1 lymph node SUVmax, and N2 lymph node SUVmax) were identified and incorporated into the nomogram. The nomogram exhibited notable discrimination, evidenced by an area under the ROC curve of 0.825 (95% CI: 0.749-0.886, P < 0.001). Excellent concordance between the predicted and observed probabilities of lymph nodal involvement was demonstrated by the calibration curve. Furthermore, decision curve analysis indicated a net benefit associated with the use of our nomogram.</p><p><strong>Conclusion: </strong>The nomogram demonstrated efficacy and practicality in predicting CT-negative lymph node metastasis for lung adenocarcinoma patients. It holds potential to offer valuable treatment guidance for clinicians.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"202"},"PeriodicalIF":1.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egyptian experience with aortic valve repair using Ozaki procedure in adult and pediatric patients.","authors":"Mohammed Emad Eldin Omar, Gehad M Mahmoud, Ahmed Fadaly, Mohamed Azzam, Ali M Abd Elwahab, Ahmed M T Ismail, Mohamed A Nady","doi":"10.1186/s13019-025-03351-8","DOIUrl":"https://doi.org/10.1186/s13019-025-03351-8","url":null,"abstract":"<p><strong>Background and aim: </strong>to document the Egyptian experience with Ozaki procedure in adults and children and compare the clinical outcomes of the procedure to that of aortic valve replacement (AVRc) in adult patients.</p><p><strong>Patients and methods: </strong>The study included adult and pediatric patients submitted to the Ozaki procedure with available 1-year follow up data. In addition, adult patients submitted to AVRc during the study period were also included for comparison. Recorded outcome parameters included intensive care unit stay, hospital stay and early and late postoperative complications and mortality.</p><p><strong>Results: </strong>The present prospective study included 72 adult and 25 pediatric patients with aortic valve disease (AVD). Adult patients were submitted to Ozaki procedure (n = 31) or AVRc (n = 41) while all pediatric patients were submitted to Ozaki procedure. One year follow up demonstrated that patients submitted to the Ozaki procedure had significantly higher peak pressure gradient (28.6 ± 7.6 versus 21.0 ± 5.7 mmHg, p < 0.001) and higher mean pressure gradient (13.5 ± 4.4 versus 10.5 ± 3.2 mmHg, p = 0.002) when compared to patients in the AVRc group. In the Ozaki group, moderate aortic stenosis (AS) was identified in only 1 patient. In the pediatric group, at one year follow up, there were 8 patients (32.0%) with trivial aortic regurgitation (AR), 12 patients (48.0%) with mild AR and 4 patients (16.0%) with moderate AS.</p><p><strong>Conclusions: </strong>Ozaki procedure appears to be a promising alternative to AVRc in adults and children with AVD with good efficacy and safety profile.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"196"},"PeriodicalIF":1.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating psychological difference between two genders in mental health after percutaneous coronary intervention for elderly patients with acute coronary syndrome.","authors":"Min'an Peng, Jie Li, Linhua Kuang, Jugen Guo, Shantao Liu, Changqing Ye","doi":"10.1186/s13019-025-03427-5","DOIUrl":"https://doi.org/10.1186/s13019-025-03427-5","url":null,"abstract":"<p><strong>Objective: </strong>Psychological factors are closely correlated with coronary heart disease, and gender discrepancies occurs in mental health after percutaneous coronary intervention (PCI) for acute coronary syndrome patients (ACS) are worth studying.</p><p><strong>Methods: </strong>This study collected data from patients aged ≥ 60 diagnosed with ACS who underwent PCI treatment within one week of admission to the Cardiovascular Department of Ji'an Central People's Hospital between June 2021 and December 2022. The study group consisted of 113 female patients, whereas the control group consisted of 121 male patients. Baseline patient data, demography, and laboratory test results were collected. Anxiety and depression were assessed using the Self-rating anxiety scale (SAS) and Self-rating depression scale (SDS) before PCI and at 1, 4, and 12 weeks post-procedure. Descriptive data are presented as x̄±s. Group comparisons for continuous variables were conducted using t-tests, while categorical data were analyzed using chi-square tests. Multiple group comparisons were conducted using analysis of variance.</p><p><strong>Results: </strong>There were no statistically significant disparities observed in baseline characteristics between these two groups. The assessment of SAS and SDS scores exhibited no statistically significant difference between the two groups before PCI; however, after the procedure, elderly female ACS patients demonstrated notably elevated SAS and SDS scores when contrasted with their elderly male ACS counterparts. Both cohorts manifested their highest SAS and SDS scores before PCI, with a gradual reduction in these scores after the procedure. Elderly female ACS patients experienced a statistically significant reduction in SAS and SDS scores at both 4- and 12 weeks post-PCI compared to their pre-PCI scores.</p><p><strong>Conclusions: </strong>Taken together, elderly female ACS patients undergoing PCI are more susceptible to the manifestation of anxiety and depression symptoms compared to their elderly male counterparts.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"192"},"PeriodicalIF":1.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous postoperative pericardial flushing to reduce the risk of postoperative bleeding after elective adult cardiac surgery - a study-level meta-analysis.","authors":"Shubham N Jain, Hiral S Jhala, Mohsin Uzzaman, Keith G Buchan","doi":"10.1186/s13019-025-03428-4","DOIUrl":"https://doi.org/10.1186/s13019-025-03428-4","url":null,"abstract":"<p><strong>Background: </strong>Retained blood syndrome contributes to higher morbidity and mortality post cardiac surgery. We investigate the benefits of continuous postoperative pericardial flushing (CPPF) over standard care chest drainage in elective adult cardiac surgery patients.</p><p><strong>Methods: </strong>Various online databases were screened for randomised controlled trials (RCTs) and observations studies comparing CPPF to standard care.</p><p><strong>Primary outcomes: </strong>12-hour and total blood loss, cardiopulmonary bypass (CPB) and aortic cross-clamp (ACC) times; surgical re-intervention for bleeding, mortality, sternal wound infections and pericardial or pleural fluid re-accumulation at discharge.</p><p><strong>Secondary outcomes: </strong>perioperative blood transfusion, time to extubation and total hospital stay.</p><p><strong>Results: </strong>586 patients from four studies with matched characteristics were included. CPPF was associated with less blood loss at 12 h and in total: Odds Ratio (OR) (95% CI) 0.71 (-0.91 to 0.51) and 0.49 (-0.67 to -0.32) (both p < 0.00001). CPPF had lower need for transfusion of blood products RR 0.57 (0.36-0.89) (p = 0.01)). There were no significant differences in surgical re-intervention rates, overall mortality, CPB, ACC times, length of hospital stay, time until extubation or sternal wound infections. Risk of pericardial or pleural fluid re-accumulation was lower in the CPPF groups RR 0.88 (0.80-0.97) (p = 0.01).</p><p><strong>Conclusions: </strong>CPPF has shown promising results in reducing postoperative blood loss and fluid re-accumulation with fewer blood transfusions, and lower surgical re-intervention rates across all ranges of cardiac surgical procedures. It is safe, feasible and effective in all types of cardiac surgery, however further studies are needed to validate these findings.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"195"},"PeriodicalIF":1.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular treatment under laparotomy with n-butyl-2-cyanoacrylate in a pediatric traumatic aortic injury: a case report.","authors":"Hikaru Oe, Shimpei Ikeda, Takahiko Mine, Yoshiaki Hara","doi":"10.1186/s13019-025-03412-y","DOIUrl":"https://doi.org/10.1186/s13019-025-03412-y","url":null,"abstract":"<p><strong>Background: </strong>The Society for Vascular Surgery (SVS) guidelines recommend thoracic endovascular aortic repair (TEVAR) for blunt traumatic aortic injuries (BTAI) in adults, especially BTAI grades II to IV. TEVAR is increasingly performed for BTAI in children and adolescents; however, reports on treatment strategies are limited. Percutaneous routes for stenting may not be available in children with anatomically small vessel diameters, and the indications for stent grafts are challenging because of the steep aortic angle.</p><p><strong>Case presentation: </strong>We report a case of TEVAR for BTAI performed under laparotomy with n-butyl-2-cyanoacrylate (NBCA) injection in an adolescent patient. The patient was a 13-year-old male who sustained injuries due to a fall and presented with severe hypoxia and shock on admission. Computed tomography (CT) showed a thoracic aortic injury with a pseudoaneurysm (SVS grade III) and bilateral pulmonary contusions. We planned to perform TEVAR after venovenous extracorporeal membrane oxygenation (ECMO); however, because of the small diameters of the bilateral common femoral arteries, we placed a stent graft through the left common iliac artery under laparotomy. In addition, the proximal landing zone of the stent graft to the thoracic pseudoaneurysm was short, and we filled the pseudoaneurysm with NBCA after deploying the stent graft to prevent endoleaks. Subsequent CTs showed no endoleaks, and the patient was discharged on day 110.</p><p><strong>Conclusions: </strong>We report a case of TEVAR in a 13-year-old boy who underwent laparotomy with NBCA injection into a pseudoaneurysm. This method may be useful as an alternative when percutaneous access is not available, and the proximal landing zone cannot be reached.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"193"},"PeriodicalIF":1.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant Kommerell diverticulectomy, carotid-subclavian bypass, and modified ravitch pectus excavatum repair via sternotomy.","authors":"Carlo R Bartoli, Shiv Patel, Victor Mallory, Deborah Miller","doi":"10.1186/s13019-025-03447-1","DOIUrl":"https://doi.org/10.1186/s13019-025-03447-1","url":null,"abstract":"<p><p>Congenital heart disease may present with pectus excavatum. Concomitant and staged repair are described, but the optimal approach is controversial. We report a 17-year-old male with left aortic arch, aberrant right subclavian artery, and Kommerell diverticulum who presented with long standing swallowing difficulties, prandial nausea, and pectus excavatum with cosmetic concerns. Kommerell diverticulectomy, carotid-subclavian bypass, and modified Ravitch pectus excavatum repair were performed without complication. Concomitant congenital heart surgery and pectus excavatum repair may be successfully performed in a single operation via sternotomy. Incidence, operative approaches, and complications of concomitant versus staged correction of congenital heart disease and pectus excavatum are briefly reviewed.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"191"},"PeriodicalIF":1.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin as a treatment for atherosclerosis: focus on programmed cell death, inflammation and oxidative stress.","authors":"Reza Asemi, Elham Omidi Najafabadi, Zahra Mahmoudian, Russel J Reiter, Mohammad Ali Mansournia, Zatollah Asemi","doi":"10.1186/s13019-025-03423-9","DOIUrl":"https://doi.org/10.1186/s13019-025-03423-9","url":null,"abstract":"<p><p>Delaying the development of atherosclerosis (AS) and decreasing cardiac ischemia-reperfusion damage remain serious challenges for the medical community. Chronic arterial disease, i.e., AS, is frequently linked to oxidative stress and inflammation as significant contributing causes. AS risk factors, such as hyperlipidemia, high blood pressure, age, hyperglycemia, smoking, high cholesterol, and irregular sleep patterns, can exacerbate AS in the carotid artery and further shrink its lumen. Finding new approaches that support plaque inhibition or stability is an ongoing problem. The last ten years have shown us that melatonin (MLT) affects the cardiovascular system, although its exact mechanisms of action are yet unknown. MLT's direct free radical scavenger activity, its indirect antioxidant qualities, and its anti-inflammatory capabilities all contribute to its atheroprotective effects on several pathogenic signaling pathways. Herein, we examine the evidence showing that MLT treatment has significant protective effects against AS and AS-related cardiovascular diseases. The numerous pieces of the puzzle that have been as for epigenetic and biogenetic targets for prevention and therapy against the atherosclerotic pathogenic processes are identified.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"194"},"PeriodicalIF":1.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}