Journal of Cardiothoracic Surgery最新文献

{"title":"Anterosuperior mediastinal paraganglioma in a 42-Year-old woman: a diagnostic and therapeutic challenge-a case report.","authors":"Zheng Wang, Wenkang Zong, Shuo Liang, Fang Zhou, Xike Lu, Daqiang Sun","doi":"10.1186/s13019-024-03283-9","DOIUrl":"10.1186/s13019-024-03283-9","url":null,"abstract":"<p><strong>Background: </strong>Paragangliomas are rare neuroendocrine tumors predominantly located within the adrenal gland. Extra-adrenal paragangliomas, particularly those in the anterosuperior mediastinum, are exceedingly rare and pose significant diagnostic and therapeutic challenges due to their complex anatomical location.</p><p><strong>Case description: </strong>A 42-year-old woman was found to have an anterosuperior mediastinal mass during a routine health screening. Enhanced chest computed tomography (CT) revealed an ovoid, low-density mass intricately associated with major vascular structures including the superior vena cava, brachiocephalic trunk, left common carotid artery, aortic arch, right anonymous vein, and right subclavian artery. Despite significant intraoperative blood loss of 2000 ml, the mass was successfully excised with meticulous surgical technique and effective hemostasis. Histopathological examination showed a classic Zellballen pattern with chief cells and sustentacular cells embedded in a vascular-rich stroma. Immunohistochemistry confirmed the tumor's chromaffin nature, with chief cells testing positive for CD56, Synaptophysin, and Chromogranin A, and sustentacular cells positive for S100 protein, consistent with a diagnosis of paraganglioma. The patient's postoperative recovery was uneventful, and she was discharged one week after surgery.</p><p><strong>Conclusions: </strong>This case highlights the essential role of comprehensive preoperative imaging and the necessity for interdisciplinary surgical expertise in managing complex mediastinal paragangliomas. Advanced surgical techniques and careful intraoperative management are paramount to achieving successful outcomes. Appropriate imaging modalities and auxiliary laboratory tests are crucial for early detection of recurrences in these rare tumors.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"182"},"PeriodicalIF":1.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between mitochondrial proteins and risks of aortic aneurysms and aortic dissection: a Mendelian randomization study.","authors":"Lei Wang, Yuzuo Lin, Ziyan Lin, Qingtong Wu, Guodong Zhong, Liangwan Chen","doi":"10.1186/s13019-025-03389-8","DOIUrl":"10.1186/s13019-025-03389-8","url":null,"abstract":"<p><strong>Background: </strong>Mitochondrial dysfunction may be linked to the development of aortic aneurysm (AA) and aortic dissection (AD). This study aimed to evaluate the potential associations between proteins related to mitochondrial function and the risks of AA/AD using Mendelian randomization (MR).</p><p><strong>Methods: </strong>Large-scale publicly available genome-wide association studies (GWAS) and FinnGen summary data were utilized for MR analysis. The causal relationship between mitochondrial proteins and AA/AD was assessed using inverse-variance weighted (IVW) as the primary method. Sensitivity analyses were conducted to detect heterogeneity and pleiotropy by Cochran's Q test, MR-Egger test, MR-PRESSO global test, and \"leave-one-out\" analysis.</p><p><strong>Results: </strong>There were potential causal relationships between several mitochondrial proteins and AA/AD. Specifically, the iron-sulfur cluster assembly enzyme ISCU (OR = 1.165, 95% CI: 1.051-1.291, P = 0.004) and NFU1 iron-sulfur cluster scaffold homolog (OR = 1.184, 95% CI: 1.056-1.329, P = 0.004) were identified as potential risk factors for AA; whereas the 39 S ribosomal protein L14 (OR = 0.868, 95% CI: 0.764-0.987, P = 0.031) was found to be a protective factor for AA. Furthermore, 39 S ribosomal protein L33 (OR = 1.134, 95% CI: 1.010-1.274, P = 0.033) and cytochrome C oxidase subunit 5B (OR = 1.330, 95% CI: 1.037-1.706, P = 0.025) were associated with increased risks of AD; whereas the 39 S ribosomal protein L52 (OR = 0.736, 95% CI: 0.550-0.984, P = 0.038) and mitochondrial ubiquitin ligase activator of NFKB 1 (OR = 0.806, 95% CI: 0.656-0.989, P = 0.039) were identified as potential protective factors for AD. Sensitivity analysis confirmed the stability of the results.</p><p><strong>Conclusions: </strong>This study identified potential genetic associations between mitochondrial proteins and AA/AD. Targeting these mitochondrial proteins may help prevent the occurrence of AA/AD.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"181"},"PeriodicalIF":1.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of postoperative home-based pulmonary function training for lung cancer patients: a real-world study.","authors":"Ziqing Xu, Yizhuo Chen, Zhouqi Zhang, Dongfang Qiao, Ming Dong","doi":"10.1186/s13019-025-03343-8","DOIUrl":"10.1186/s13019-025-03343-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pulmonary surgery can significantly impact patients' respiratory function and reduce their quality of life. Previous studies have shown that perioperative breathing exercises (BE) can facilitate the recovery of lung function and improve patients' quality of life after surgery. However, due to the lack of supervision and awareness, patients often struggle to adhere to the prescribed exercise regimen. This study statistics and analyzes the effect of postoperative respiratory function training on postoperative recovery of patients undergoing pneumonectomy in a realistic environment, in order to provide a basis for optimizing postoperative rehabilitation strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Patients undergoing surgical treatment for pulmonary nodules received standardized education upon admission, including guidance on performing breathing exercises. Preoperative pulmonary function tests (PFT) and arterial oxygen saturation measurements were conducted, and patients were instructed to return for follow-up pulmonary function and arterial oxygen saturation assessments at 1 month, 3 months, and 6 months post-surgery. In addition, patients were asked to complete online questionnaires at these time points. Oxygen saturation levels were also re-assessed before discharge, and patients were encouraged to complete a discharge questionnaire. Weekly phone calls were made to remind patients to continue their breathing exercises. The study analyzed 12 potential factors that might affect the outcomes, including preoperative nebulization use, surgical method, and patient age. The primary outcome measures were the effects of postoperative breathing exercises on FEV1, FVC, DLCO, and SPO2 at 1 month (T1), 3 months (T2), and 6 months (T3) post-surgery. Secondary outcomes included LCQ cough assessment, FACT-L quality of life assessment, evaluations of pain and appetite, SAS anxiety level, SDS depression level, AIS sleep quality, and the modified MRAC assessment of dyspnea symptoms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study initially enrolled 296 patients (T0), including 233 patients who underwent sublobar resection (SRP) and 63 patients who underwent lobectomy (LBP). Between T0 and T1, 203 patients remained in the SRP group and 47 in the LBP group. Between T0 and T2, 36 patients remained in the SRP group and 9 in the LBP group. By T3, the SRP group had 14 patients, and the LBP group had 5 patients remaining. Due to incomplete data, SPO2 measurements were excluded from the analysis. Additionally, the SRP group at T3 and the LBP group at T2 and T3 were not included in the analysis.In the SRP group, at T1, the BE group showed significantly better recovery in FEV1 and FVC compared to the control group. By T2, the BE group had a significantly improved sleep quality compared to the control group (P &lt; 0.05). In the LBP group, at T1, the BE group demonstrated a significant advantage in alleviating anxiety symptoms compared to the control gr","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"179"},"PeriodicalIF":1.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular fibromas in pediatric patients: a case series and review of the literature.","authors":"Chun Zhou, Jia Liu, Shoujun Li, Huiying Wang, Yu Jin, Jinping Liu","doi":"10.1186/s13019-025-03382-1","DOIUrl":"10.1186/s13019-025-03382-1","url":null,"abstract":"<p><p>Cardiac fibromas are rare benign primary tumors of the heart; nearly one-third of affected patients are less than 1 year old, and only 15% of patients develop this disease in adulthood. Here, we report three cases of cardiac fibroma in our hospital. In all the patients, the cardiac mass was diagnosed using cardiac imaging, namely CT and MRI scans. The tumors were surgically resected under cardiopulmonary bypass, and the fibroma was diagnosed by histopathology and microscopy. The cardiac function of the three pediatric patients recovered after the operation, and the patients were discharged successfully.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"180"},"PeriodicalIF":1.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine as part of multi-modal analgesia may reduce opioid requirements following cardiac surgery: a retrospective observational cohort study.","authors":"James Hall, Juri Chung, Michael Khilkin, George Elkomos-Botros","doi":"10.1186/s13019-025-03405-x","DOIUrl":"10.1186/s13019-025-03405-x","url":null,"abstract":"<p><strong>Background: </strong>Postoperative pain control in cardiac surgery is often managed with opioid medications. Insufficient analgesia can result in complications including splinting, pneumonia, and delay of appropriate rehabilitation. Given the risks and adverse effects of opioids including sedation, respiratory depression, delirium, and decreased gastrointestinal motility, hyperalgesia and potential for addiction, strategies for opioid reduction are likely to improve outcomes, therefore multimodal opioid sparing pain regimens are preferred. Recently, there is increased evidence that low dose Ketamine, an N-methyl-D-Aspartate (NMDA) receptor antagonist, is safe and effective for analgesia in postoperative patients and may be appropriate to this setting.</p><p><strong>Methods: </strong>This is a single center, retrospective, observational, cohort study over a one year period involving postoperative adult cardiac surgery comparing those who received a single dose of postoperative ketamine, 0.3 mg/kg over 30 min, with those who did not receive any ketamine. Other analgesic protocols were similar between groups and did not include additional ketamine. A total of 120 patient charts were reviewed, of which 96 met inclusion criteria, 32 in the ketamine group and 64 in the standard care group. Charts were reviewed for opioid and other pain medication requirements during the postoperative period and on discharge, and for secondary outcomes: hospital length of stay, ICU length of stay, in-hospital and 30-day mortality, 30-day readmission, and rates of delirium, emergence reactions, and need for escalated respiratory support.</p><p><strong>Results: </strong>The group who received postoperative ketamine required 28.8 morphine milligram equivalents (MME) less postoperative opioid (90.1 mg vs 118.9 mg, p = 0.167), and was prescribed an average of 15.8 MME less on discharge (p < 0.001). Intraoperatively, both groups received 1000 mg acetaminophen, 2 mg intravenous morphine and 100 mcg fentanyl, 26 MME, by protocol. No ketamine was administered intraoperatively or preoperatively. The groups differed in respect to operation type and controlling for this parameter failed to achieve significance in needs during admission (p = 0.215), but remained significant on discharge (p = 0.02). The non-ketamine group received more ketorolac (15.5 vs 10.1, p = 0.06). The ketamine group required less acetaminophen but more gabapentin. There was no difference in hospital or ICU length of stay. There was no delirium or mortality in either group. Respiratory depression occurred in 15 patients who all subsequently received ketamine. No patient developed respiratory depression after ketamine.</p><p><strong>Conclusions: </strong>Ketamine may be a reasonable choice for postoperative cardiac surgery analgesia and may reduce the need for opioids on discharge, and possibly during admission.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"178"},"PeriodicalIF":1.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation of bronchial anatomy and variation of the middle lobe of the right lung based on three-dimensional reconstruction of lung CT.","authors":"Bin Zhao, Wenbo Wu, Guochen Duan","doi":"10.1186/s13019-025-03402-0","DOIUrl":"10.1186/s13019-025-03402-0","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the anatomical types and variations of lung segments and subsegment bronchi based on CT 3D reconstruction technology, and to provide anatomical theoretical support for thoracic surgeons in terms of surgical techniques.</p><p><strong>Methods: </strong>The 3D CT reconstructed images of 541 patients were retrospectively analyzed. We explored the anatomical structure of the bronchi in the middle lobe of the right lung, sorted out the variations, and classified them in detail according to different bronchial types.</p><p><strong>Results: </strong>In the CT 3D reconstruction of 541 patients, the bronchial anatomical types of the right middle lobe were divided into two types. There were 530 cases (98.0%) of two-branched type and 11 cases (2.0%) of three-branched type, and no four-branched type was found in the data of this paper. In addition, the spatial relationship between B₄ and B₅, and the spatial relationship between subsegmental bronchi B_4a, B_4b, B_5a, and B_5b are analyzed. The most common anatomical type and spatial relationship of the right middle lobe bronchi in the two-branched type were B₄ and B₅ in the external-internal relationship, B_4a and B_4b in the external-internal relationship, and B_5a and B_5b in the upper and lower relationship, and this subtype was 416 cases (76.9%). In addition, 23 cases (3.9%) were found to have a spatial relationship between B₄ and B₅ in the right middle lobe similar to the lingual bronchial subtype in the left upper lobe.</p><p><strong>Conclusion: </strong>We used a large number of CT 3D reconstructed images to explore the anatomical types and variations of the bronchi in the middle lobe of the right lung. Thoracic surgeons can use our data to guide increasingly delicate lobectomy and segmentectomy.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"172"},"PeriodicalIF":1.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of modified neck drainage in the management of cervical anastomotic fistula in esophageal cancer patients.","authors":"Song Wu, Zhe Zhang, Zhonghua Qin","doi":"10.1186/s13019-025-03401-1","DOIUrl":"10.1186/s13019-025-03401-1","url":null,"abstract":"<p><strong>Background: </strong>Anastomotic fistula is a rare but life-threatening complication of esophageal cancer, and its treatment remains challenging.We aimed to evaluate the clinical efficacy of modified cervical drainage in the management of cervical anastomotic fistula in patients after esophageal cancer surgery.</p><p><strong>Methods: </strong>From June 2017 to December 2021, 25 esophageal cancer patients who developed cervical anastomotic fistula were enrolled in the study. Among them, 14 patients were treated with modified cervical drainage, which served as the observation group, while the remaining 11 patients underwent open incision and drainage, which served as the control group. The treatment outcomes of the two groups were compared and analyzed.</p><p><strong>Results: </strong>The observation group had a significantly shorter healing time, fewer dressing changes, shorter hospital stay, and lower hospitalization costs compared to the control group (P < 0.05). The incidence of complications in the neck was not significantly different between the two groups (P > 0.05). All patients resumed a normal diet without experiencing fever, coughing or other discomfort, and were discharged after a smooth recovery.</p><p><strong>Conclusions: </strong>Modified neck drainage, as a treatment method for cervical anastomotic leakage in esophageal cancer patients, has preliminarily demonstrated potential in promoting patient recovery. However, its efficacy still requires further validation and confirmation through studies with larger sample sizes.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"173"},"PeriodicalIF":1.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time blood gas management: evaluating quantum perfusion system's accuracy against a standard blood gas analysis in CPB.","authors":"Bahi Hyasat, Amjad Bani Hani, Ali Al Saraireh, Rana Al Kirmeen, Dina Sabha, Saif Yamin, Islam Massad, Ayman Hammoudeh","doi":"10.1186/s13019-025-03409-7","DOIUrl":"10.1186/s13019-025-03409-7","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Continuous blood gas monitoring (CBGM) during cardiopulmonary bypass (CPB) is essential for maintaining optimal patient outcomes, enabling rapid responses to critical fluctuations in blood gas parameters. This non-inferiority study evaluates the Quantum Perfusion System by Spectrum Medical, which features continuous online blood gas monitoring through Quantum workstation (QWS) and Quantum ventilation module (QVM) without the use of cuvettes, against the standard blood gas analysis (BGA) analyzer to assess real-time clinical accuracy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective study included a sample of 40 patients, monitored continuously with the QPS and compared at intervals against standard BGA measurements. The patients undergoing on elective CPB procedures, specifically for coronary artery bypass grafting (CABG), mitral valve replacement (MVR), and aortic valve replacement (AVR).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Pre-alignment deviations for all parameters were within CLIA thresholds, confirming baseline reliability. For hemoglobin, the pre-alignment deviation was 1.9%, which decreased to 0.7% post-alignment, both within the CLIA threshold of ± 5%, with a Bland-Altman mean difference of 0.0988 g/dL (limits: 0.0963 to 0.1012 g/dL). Hematocrit showed a pre-alignment deviation of 2.1%, reduced to 0.2% post-alignment, both within the CLIA threshold of ± 5%, with a Bland-Altman mean difference of 0.3009% (limits: 0.2956 to 0.3063%). For PaO₂, the pre-alignment deviation was 3.9%, reduced to 0.4% post-alignment, both within the CLIA threshold of ± 10%, with a Bland-Altman mean difference of 4.0490 mmHg (limits: 3.9976 to 4.1004 mmHg). PCO₂ demonstrated a pre-alignment deviation of 4.2%, reduced to 0.19% post-alignment, both within the CLIA threshold of ± 10%, with a Bland-Altman mean difference of 0.3790 mmHg (limits: 0.3751 to 0.3829 mmHg). SvO₂ showed a pre-alignment deviation of 3%, which decreased to 0.8% post-alignment, both within the CLIA threshold of ± 5%, with a Bland-Altman mean difference of 0.7782% (limits: 0.7706 to 0.7858%). Finally, for SaO₂, the pre-alignment deviation was 2.6%, reduced to 0.1% post-alignment, both within the CLIA threshold of ± 5%, with a Bland-Altman mean difference of 0.9614% (limits: 0.9594 to 0.9634%). The Passing-Bablok regression analysis confirmed strong agreement, with slopes close to 1.0100 and intercepts near zero for all parameters. These results validate the QPS as a reliable and non-inferior tool for real-time blood gas monitoring during cardiopulmonary bypass, adhering to CLIA standards and ensuring clinical accuracy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The findings support the accuracy of the Quantum Perfusion System compared to the BGA standard, demonstrating the system's capability to provide accurate, continuous blood gas monitoring during CPB. However, further studies are necessary to strengthen and confirm these results across broader and more varied clinica","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"176"},"PeriodicalIF":1.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA FAM66C predicts poor prognosis in patients with lung adenocarcinoma and regulates cell proliferation and metastasis via miR-339-3p.","authors":"Xi Chen, Wenhui Xu, Yuan Shen, Anning Qi, Huiling Qin","doi":"10.1186/s13019-025-03374-1","DOIUrl":"10.1186/s13019-025-03374-1","url":null,"abstract":"<p><strong>Background: </strong>As one of the tumors with the highest fatality rates in the world, LUAD has a high risk of concealment, recurrence, and metastasis, which has turned into a significant issue in the medical community. To find possible treatment targets for LUAD, the study investigated the relationship between FAM66C and the prognosis of LUAD as well as the mechanism by which it interacts with miR-339-3p.</p><p><strong>Methods: </strong>Tissue samples and clinicopathological data were collected from 117 LUAD patients. Polymerase chain reaction assay was used to find FAM66C and miR-339-3p expression in LUAD tissues. Utilizing CCK-8, Transwell, and flow cytometry, the relationship between LUAD cell proliferation, migration, apoptosis, and FAM66C expression was assessed. The dual luciferase reporter gene assay was utilized to investigate the interaction between miR-339-3p and FAM66C. The prognostic potential and connection of FAM66C with clinicopathology were evaluated using the Chi-square test, Kaplan-Meier, and multivariate Cox regression analysis.</p><p><strong>Results: </strong>FAM66C expression was drastically reduced and miR-339-3p expression was upregulated in LUAD cells and tissues. There was a negative correlation between FAM66C and miR-339-3p. FAM66C inhibits the expression of miR-339-3p, and miR-339-3p can reverse the inhibitory impact of FAM66C on LUAD cells. FAM66c expression was substantially associated with clinical TNM stage and lymph node metastases When FAM66C expression is low, the prognosis of LUAD patients is bad.</p><p><strong>Conclusions: </strong>In conclusion, lower FAM66C expression can be utilized to predict the poor prognosis of LUAD, and FAM66C is negatively linked with miR-339-3p, which can influence cancer cell development by modulating miR-339-3p expression.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"175"},"PeriodicalIF":1.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of right atrial perforation and pericardial tamponade following leakage of bone cement.","authors":"Renlang Liu, Zhirong Wang, Zhiwei Zhang, Hong You, Qi Ai, Wancun Jin, Qin Wu","doi":"10.1186/s13019-025-03403-z","DOIUrl":"10.1186/s13019-025-03403-z","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous vertebroplasty is commonly used to treats vertebral fractures, tumors, and osteolytic vertebral metastases. However, cement leakage during the procedure can lead to severe complications, including cardiac perforation. This report presents a case of right atrial perforation and pulmonary embolism caused by cement leakage, emphasizing the clinical significance of these events and discussing the treatment strategy.</p><p><strong>Case presentation: </strong>A 57-year-old female was admitted to the hospital with a slipped lumbar vertebra and back pain, for which she underwent percutaneous vertebroplasty. On the 10th postoperative day, the patient suddenly developed chest tightness and shortness of breath, accompanied by a gradual decline in hemoglobin levels. After several imaging studies, a diagnosis of right atrial perforation caused by bone cement was confirmed. The patient subsequently underwent open cardiac foreign body removal and made a full recovery, with no residual cardiac dysfunction.</p><p><strong>Conclusion: </strong>This case highlights the rare but serious complication of right atrial perforation caused by bone cement leakage during percutaneous vertebroplasty. The report emphasizes the importance of early identification of bone cement-related complications. While conservative management may suffice for pulmonary embolism, urgent surgical treatment is required for cardiac cement embolism to prevent further complications.</p>","PeriodicalId":15201,"journal":{"name":"Journal of Cardiothoracic Surgery","volume":"20 1","pages":"174"},"PeriodicalIF":1.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}