Surgical myectomy might inhibit ascending aortic dilation in obstructive hypertrophic cardiomyopathy: a serial cardiac magnetic resonance study.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiothoracic Surgery Pub Date : 2025-10-22 DOI:10.1186/s13019-025-03592-7

Changpeng Song, Xinli Guo, Xinxin Zheng, Jie Lu, Jingang Cui, Shuiyun Wang, Xiaohong Huang

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引用次数: 0

Abstract

Background: The impact of septal myectomy on the progression of ascending aortic (AAo) dilation in patients with obstructive hypertrophic cardiomyopathy (HOCM) remains uncertain. This study aimed to investigate the relationship between septal myectomy and AAo dilation in HOCM patients.

Methods: A total of 69 patients with HOCM were enrolled. All the participants underwent sequential cardiac magnetic resonance scans at a mean interval of 5.13 ± 2.04 years, with each scan being more than 3 years apart.

Results: At baseline, 17 patients with HOCM (25%) exhibited AAo dilation (Indexed AAo dimension > 19 mm/m²). Age (OR 1.10, 95%CI: 1.01-1.019, P = 0.026) and female (OR 4.80, 95%CI: 1.05-21.93, P = 0.043) were independently associated with AAo dilation. In patients who underwent myectomy, the AAo dimension at follow-up was similar to that at baseline (32.47 ± 4.70 mm vs. 32.81 ± 5.06 mm, P = 0.197). Furthermore, the rate of AAo dilation was lower in patients with myectomy compared to those without myectomy (-0.06 ± 0.38 mm/year vs. 0.18 ± 0.43 mm/year, P = 0.016). Additionally, moderate or severe mitral regurgitation was significantly associated with AAo dilation rate (B = 0.273, P = 0.032).

Conclusions: Myectomy in patients with HOCM was associated with the absence of progression of AAo dilatation.

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外科肌瘤切除术可能抑制阻塞性肥厚性心肌病的升主动脉扩张：一项系列心脏磁共振研究。

背景：中隔肌切除术对阻塞性肥厚性心肌病（HOCM）患者升主动脉（AAo）扩张进展的影响尚不确定。本研究旨在探讨HOCM患者鼻中隔肌切除术与AAo扩张的关系。方法：共纳入69例HOCM患者。所有参与者平均间隔5.13±2.04年进行连续心脏磁共振扫描，每次扫描间隔超过3年。结果：基线时，17例HOCM患者（25%）出现AAo扩张（AAo指数尺寸> 19 mm/m²）。年龄（OR 1.10, 95%CI: 1.01 ~ 1.019, P = 0.026）和女性（OR 4.80, 95%CI: 1.05 ~ 21.93, P = 0.043）与AAo扩张独立相关。在行肌瘤切除术的患者中，随访时AAo尺寸与基线时相似（32.47±4.70 mm vs. 32.81±5.06 mm, P = 0.197）。此外，肌瘤切除术患者的AAo扩张率低于未切除术患者（-0.06±0.38 mm/年vs. 0.18±0.43 mm/年，P = 0.016）。此外，中度或重度二尖瓣返流与AAo扩张率显著相关（B = 0.273, P = 0.032）。结论：HOCM患者行Myectomy与AAo扩张无进展相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiothoracic Surgery 医学-心血管系统

CiteScore

2.50

自引率

6.20%

发文量

286

审稿时长

4-8 weeks

期刊介绍： Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.