Journal of biomedical materials research. Part A最新文献

{"title":"The Role of Implant Coronal Surface Properties on Early Adhesion of Streptococcus Oralis—An In Vitro Comparative Study","authors":"Xuesong Wang,&nbsp;Robert S. Liddell,&nbsp;Hai Bo Wen,&nbsp;John E. Davies,&nbsp;Elnaz Ajami","doi":"10.1002/jbm.a.37866","DOIUrl":"10.1002/jbm.a.37866","url":null,"abstract":"<div>\u0000 \u0000 <p>Dental implant coronal surfaces designed with the primary goal of maintaining crestal bone levels may also promote bacterial adhesion, leading to soft tissue inflammation and peri-implant bone loss. Achieving an optimal surface roughness that minimizes bacterial adhesion while preserving crestal bone is crucial. It is hypothesized that a specific threshold surface roughness value may exist below which, and above which, initial bacterial adhesion does not statistically change. This study evaluated 12 commercially available and 2 custom-designed implant surfaces for their physicochemical properties and initial bacterial adhesion, as represented by <i>Streptococcus oralis</i> (<i>S. oralis</i>) the dominant initial colonizer of the successive waves of bacterial consortia that result in plaque and biofilm formation. Implants were immersed in a <i>S. oralis</i> suspension for 4 h, after which microbial viability was assessed. Marked differences were observed in surface roughness, chemical composition, and wettability, and <i>S. oralis</i> adhesion. Surfaces with Sa &gt; 1 μm had significantly more adherent bacteria after 4 h compared to those with Sa &lt; 1 μm, despite complexity. Adding nanotopography to dual-acid etched surfaces further reduced bacterial adhesion compared to surfaces without these features. The role of chemical composition and wettability was less influential than roughness. In conclusion, there is a cut-off threshold roughness around Sa = 1 μm, above which the adhesion of bacteria increases significantly to a plateau level; while below which, bacterial adhesion is equivalent to a machined surface despite the surface texture of the implant collar.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Cationic Micelle Delivery of a Multi-Epitope Vaccine Candidate Derived From Tumor-Associated Antigens, Causing Regression in Established CT26 Colorectal Tumors in Mice”","authors":"","doi":"10.1002/jbm.a.37810","DOIUrl":"10.1002/jbm.a.37810","url":null,"abstract":"<p>F. Sabzehei, A. H. Taromchi, A. Ramazani, et al., “Cationic Micelle Delivery of a Multi-Epitope Vaccine Candidate Derived From Tumor-Associated Antigens, Causing Regression in Established CT26 Colorectal Tumors in Mice,” <i>Journal of Biomedical Materials Research Part A</i> 112, no. 5 (2024): 733–742, https://doi.org/10.1002/jbm.a.37654.</p><p>We state here that, the animal approval statement was removed by mistake from the published article and that the ethics approval statement should read as follows:</p><p>The research was approved by the Ethics Committee, Zanjan University of Medical Sciences (Approved Number: IR.ZUMS.REC.1398.034).</p><p>We apologize for these errors.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37810","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Situ Gelling Silk Fibroin/ECM Hydrogel With Sustained Oxygen Release for Neural Tissue Engineering Applications","authors":"Mahyar Haki,&nbsp;Nadia Shafaei,&nbsp;Mohammad Moeini","doi":"10.1002/jbm.a.37837","DOIUrl":"10.1002/jbm.a.37837","url":null,"abstract":"<div>\u0000 \u0000 <p>In situ gelling, cell-laden hydrogels hold promise for regenerating tissue lesions with irregular shapes located in complex and hard-to-reach anatomical sites. A notable example is the regeneration of neural tissue lost due to cerebral cavitation. However, hypoxia-induced cell necrosis during the vascularization period imposes a significant challenge to the success of this approach. Oxygen-releasing hydrogels have been developed to address this issue, but they suffer from fast oxygen release over a short period, limiting their efficacy. This study develops an in situ gelling hydrogel system based on silk fibroin (SF) and decellularized brain extracellular matrix (dECM) with sustained oxygen release and tunable gelation time. Calcium peroxide nanoparticles (CPO NPs) served as the oxygen generating material, which were encapsulated within SF microparticles before incorporation into the SF-dECM hydrogel, aiming to regulate the oxygen release rate. The total CPO content of the hydrogels was only 2%–4% w/w. Characterization of hydrogels containing various SF concentrations (2%, 4% or 6% w/v) and microparticle loadings (10%, 15% or 20% w/w) demonstrated that SF concentration in the hydrogel matrix significantly affects the swelling, resorption rate and mechanical properties, while microparticle loading has a milder effect. On the other hand, microparticle loading strongly affected the oxygen release profile. High SF concentration in the hydrogel matrix (6% w/v) led to slow resorption rate and high stiffness, likely unsuitable for intended application. Low SF concentration (2% w/v), on the other hand, led to a high swelling ratio and a less sustained oxygen release. Among 4% w/v SF hydrogels, increased microparticle loading led to a slower resorption rate, increased stiffness and enhanced oxygen release. However, cell viability was reduced at 20% w/w microparticle loading, likely due to decreased cell attachment. The 4% w/v SF hydrogels containing 10% w/w SF-CPO microparticles exhibited relatively low swelling ratio (12.8% ± 2.4%), appropriate resorption rate (70.16% ± 10.75% remaining weight after 28 days) and compressive modulus (36.9 ± 1.7 kPa) and sustained oxygen release for over 2 weeks. This sample also showed the highest viability under hypoxic conditions among tested hydrogel samples (87.6% ± 15.9%). Overall, the developed hydrogels in this study showed promise for potential application in brain tissue engineering.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Basic Fibroblast Growth Factor Delivery Strategies and Applications in Regenerative Medicine","authors":"Yuhan Tu,&nbsp;Yang Li,&nbsp;Gaoer Qu,&nbsp;Yangyang Ning,&nbsp;Bin Li,&nbsp;Guoben Li,&nbsp;Min Wu,&nbsp;Shijun Li,&nbsp;Yangge Huang","doi":"10.1002/jbm.a.37834","DOIUrl":"10.1002/jbm.a.37834","url":null,"abstract":"<div>\u0000 \u0000 <p>Basic fibroblast growth factor (bFGF) is a significant member of the fibroblast growth factor (FGF) family. The bFGF has a three-dimensional structure comprising 12 reverse parallel β-folds. This structure facilitates tissue wound repair, angiogenesis, bone formation, cartilage repair, and nerve regeneration. Consequently, it has garnered significant attention from scholars both domestically and internationally. However, the instability and degradation properties of bFGF in vivo have limited its clinical application. Significant interest has arisen in the development of novel bFGF delivery systems that can address the shortcomings of bFGF and enhance its bioavailability by controlling the release amount, timing, and location. This article offers a comprehensive overview of the research and recent advances in various bFGF delivery systems, including hydrogels, liposomes, microspheres, and nanoparticles. Subsequently, the applications of bFGF pharmaceutical preparations in various fields are described. Finally, the current clinical applications of bFGF drug formulations and those in clinical trials are discussed, along with their clinical translation and future trends.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Various Dry Electrode-Based ECG Sensors: A Review","authors":"Ghanshyam Kumar,&nbsp;Bhanu Duggal,&nbsp;J. P. Singh,&nbsp;Yash Shrivastava","doi":"10.1002/jbm.a.37845","DOIUrl":"10.1002/jbm.a.37845","url":null,"abstract":"<div>\u0000 \u0000 <p>Long-term electrocardiogram (ECG) monitoring is crucial for detecting and diagnosing cardiovascular diseases (CVDs). Monitoring cardiac health and activities using efficient, noninvasive, and cost-effective techniques such as ECG can be vital for the early detection of different CVDs. Wet electrode-based traditional ECG techniques come with unavoidable limitations of the altered quality of ECG signals caused by gel volatilization and unwanted noise followed by dermatitis. The limitation related to the wet electrodes for long-term ECG monitoring in static and dynamic postures reminds us of the urgency of a suitable substitute. Dry electrodes promise long-term ECG monitoring with the potential for significant noise reduction. This review discusses traditional and alternative techniques to record ECG in terms of meeting the efficient detection of CVDs by conducting a detailed analysis of different types of dry electrodes along with materials (substrate, support, matrix, and conductive part) used for fabrication, followed by the number of human subjects they have been used for validation. The degradation of these electrodes has also been discussed briefly. This review finds a need for more validation on a sufficient number of subjects and the issue of cost and noise hindering the commercialization of these dry electrodes.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Characterization of Polyvinyl Alcohol/Kappa-Carrageenan Pickering Emulsion Biocomposite Films for Potential Wound Care Applications","authors":"Ayşenur Yeşilyurt,&nbsp;Gopiraman Mayakrishnan,&nbsp;Uğur Parın,&nbsp;Ick Soo Kim,&nbsp;Fatma Nur Parın,&nbsp;Azeem Ullah","doi":"10.1002/jbm.a.37850","DOIUrl":"10.1002/jbm.a.37850","url":null,"abstract":"<p>This study aimed to develop polyvinyl alcohol (PVA) and kappa-carrageenan (κCA) biocomposite films using a Pickering emulsion technique for wound care applications. Juniper essential oil and modified sepiolite were incorporated to enhance functionality, with films prepared via solvent casting and characterized for structural, thermal, and mechanical properties. The PCOS-2 film exhibited the highest mechanical performance, with Young's modulus of 6.25 ± 1.3 MPa, tensile strength of 5.65 ± 1.7 MPa, and elongation at break of 608.96% ± 72.8%. Antibacterial assays showed inhibition zones of 9 and 10 mm against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>, respectively, for the PCOS-2 film, while antioxidant activity reached 63% DPPH radical scavenging after 12 h. Additionally, porosity and hydrophilicity were enhanced, as indicated by contact angles of 55° for the control film and 71.2° for PCOS-2. These results underscore the potential of PVA/κCA biocomposite films as sustainable and bioactive wound dressings, combining mechanical resilience, bioactivity, and environmental compatibility, with future efforts focused on optimizing antibacterial efficacy against gram-negative bacteria and clinical validation.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular Peptide Depots for Glucose-Responsive Glucagon Delivery","authors":"Weike Chen,&nbsp;Sihan Yu,&nbsp;Bernice Webber,&nbsp;Emily L. DeWolf,&nbsp;Rory Kilmer,&nbsp;Sijie Xian,&nbsp;Connor R. Schmidt,&nbsp;Elizabeth M. Power,&nbsp;Matthew J. Webber","doi":"10.1002/jbm.a.37854","DOIUrl":"10.1002/jbm.a.37854","url":null,"abstract":"<div>\u0000 \u0000 <p>Precise blood glucose control continues to be a critical challenge in the treatment and management of type 1 diabetes in order to mitigate both acute and chronic complications. This study investigates the development of a supramolecular peptide amphiphile (PA) material functionalized with phenylboronic acid (PBA) for glucose-responsive glucagon delivery. The PA-PBA system self-assembles into nanofibrillar hydrogels in the presence of physiological glucose levels, resulting in stable hydrogels capable of releasing glucagon under hypoglycemic conditions. Glucose responsiveness is driven by reversible binding between PBA and glucose, which modulates the electrostatic interactions necessary for hydrogel formation and dissolution. Through comprehensive in vitro characterization, including circular dichroism, zeta potential measurements, and rheological assessments, the PA-PBA system is found to exhibit glucose-dependent assembly, enabling controlled glucagon release that is inversely related to glucose concentration. Glucagon release is accelerated under low glucose conditions, simulating a hypoglycemic state, with a reduced rate seen at higher glucose levels. Evaluation of the platform in vivo using a type 1 diabetic mouse model demonstrates the efficacy in protecting against insulin-induced hypoglycemia by restoring blood glucose levels following an insulin overdose. The ability to tailor glucagon release in response to fluctuating glucose concentrations underscores the potential of this platform for improving glycemic control. These findings suggest that glucose-stabilized supramolecular peptide hydrogels hold significant promise for responsive drug delivery applications, offering an approach to manage glucose levels in diabetes and other metabolic disorders.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conductive Microfibers Improve Stem Cell-Derived Cardiac Spheroid Maturation","authors":"Gisselle Gonzalez,&nbsp;Thomas G. Molley,&nbsp;Erin LaMontagne,&nbsp;Alis Balayan,&nbsp;Alyssa R. Holman,&nbsp;Adam J. Engler","doi":"10.1002/jbm.a.37856","DOIUrl":"10.1002/jbm.a.37856","url":null,"abstract":"<div>\u0000 \u0000 <p>Conventional two-dimensional (2D) cardiomyocyte differentiation protocols create cells with limited maturity, which impairs their predictive capacity and has driven interest in three-dimensional (3D) engineered cardiac tissue models of varying maturity and scalability. Cardiac spheroids are attractive high-throughput models that have demonstrated improved functional and transcriptional maturity over conventional 2D differentiations. However, these 3D models still tend to have limited contractile and electrical maturity compared to highly engineered cardiac tissues; hence, we incorporated a library of conductive polymer microfibers in cardiac spheroids to determine if fiber properties could accelerate maturation. Conductive microfibers improved contractility parameters of cardiac spheroids over time versus nonconductive fibers, specifically, when they were short, for example, 5 μm, and when there was moderate fiber mass per spheroid, for example, 20 μg. Spheroids with optimal conductive microfiber length and concentration developed a thicker ring-like perimeter and a less compacted cavity, improving their contractile work compared to control cardiac spheroids. Functional improvements correlated with increased expression of contractility and calcium handling-related cardiac proteins, as well as improved calcium handling abilities and drug response. Taken together, these data suggest that conductive microfibers can improve cardiac spheroid performance to improve cardiac disease modeling.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porous Nanocomposite Implants With Gold Nanoparticles for Plastic Surgery","authors":"Olena Korotych,&nbsp;Svitlana Dybkova,&nbsp;Anatolii Maletskyi,&nbsp;Liudmyla Rieznichenko,&nbsp;Liudmyla Kernosenko,&nbsp;Tamara Gruzina,&nbsp;Tetiana Poltoratska,&nbsp;Oleksandr Artiomov,&nbsp;Nataliia Pasmurtseva,&nbsp;Valentyna Podolska,&nbsp;Pavlo Vorotytskiy,&nbsp;Yurii Samchenko","doi":"10.1002/jbm.a.37851","DOIUrl":"10.1002/jbm.a.37851","url":null,"abstract":"<div>\u0000 \u0000 <p>This study presents an innovative approach to improve implant biointegration and reduce implant-associated infections using porous poly(vinyl formal) nanocomposite matrices incorporated with gold nanoparticles and antimicrobial/anticancer drugs for plastic surgery applications. The porous matrices were characterized using physicochemical techniques and in vitro biochemical assays. The results demonstrated the biocompatibility of PVF nanocomposites and their potential for functionalization with various bioactive molecules and drugs, thereby enhancing their therapeutic efficacy. In vivo studies in rabbits revealed progressive replacement of implants with fibrous tissue, indicating successful biointegration with the surrounding soft tissues. Future research will focus on the long-term biocompatibility and functionalization of these nanocomposite implants for plastic surgery and explore their potential in other biomedical applications such as wound healing, tissue engineering, and scaffolds for cell growth and differentiation.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrically Conductive Injectable Silk/PEDOT: PSS Hydrogel for Enhanced Neural Network Formation","authors":"Rajiv Borah,&nbsp;Julia O'Sullivan,&nbsp;Meenakshi Suku,&nbsp;Dahnan Spurling,&nbsp;Daniel Diez Clarke,&nbsp;Valeria Nicolosi,&nbsp;Maeve A. Caldwell,&nbsp;Michael G. Monaghan","doi":"10.1002/jbm.a.37859","DOIUrl":"10.1002/jbm.a.37859","url":null,"abstract":"<p>With no effective treatments for functional recovery after injury, spinal cord injury (SCI) remains one of the unresolved healthcare challenges. Human induced pluripotent stem cell (hiPSC) transplantation is a versatile patient-specific regenerative approach for functional recovery after SCI. Injectable electroconductive hydrogel (ECH) can further enhance the cell transplantation efficacy through a minimally invasive manner as well as recapitulate the native bioelectrical microenvironment of neural tissue. Given these considerations, we report a novel ECH prepared through self-assembly facilitated in situ gelation of natural silk fibroin (SF) derived from mulberry <i>Bombyx mori</i> silk and electrically conductive PEDOT:PSS. PEDOT:PSS was pre-stabilized to prevent the potential delamination of its hydrophilic PSS chain under aqueous environment using 3% (v/v) (3-glycidyloxypropyl)trimethoxysilane (GoPS) and 3% (w/v) poly(ethylene glycol)diglycidyl ether (PeGDE). The resultant ECH formulations are easily injectable with standard hand force with flow point below 100 Pa and good shear-thinning properties. The ECH formulations with unmodified and GoPS-modified PEDOT:PSS, that is, SF/PEDOT and SF/PEDOT<i>GoP</i> maintain comparable elastic modulus to spinal cord (~10–60 kPa) under physiological condition, indicating their flexibility. The GoPS-modified ECHs also display improved structural recoverability (~70%–90%) as compared to the unmodified versions of the ECHs (~30%–80%), as indicated by the three interval time thixotropy (3ITT) test. Additionally, these ECHs possess electrical conductivity in the range of ~0.2–1.2 S/m comparable to spinal cord (1–10 S/m), indicating their ability to mimic native bioelectrical environment. Approximately 80% or more cell survival was observed when hiPSC-derived cortical neurons and astrocytes were encapsulated within these ECHs. These ECHs support the maturation of cortical neurons when embedded for 7 days, fostering the development of a complex, interconnected network of long axonal processes and promoting synaptogenesis. These results underline the potential of silk ECHs in cell transplantation therapy for spinal cord regeneration.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37859","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}