Journal of biomedical materials research. Part A最新文献

{"title":"Regenerated nanofibrous cellulose electrospun from ionic liquid: Tuning properties toward tissue engineering.","authors":"Ingrida Pauliukaitytė,Darius Čiužas,Edvinas Krugly,Odeta Baniukaitienė,Mindaugas Bulota,Vilma Petrikaitė,Dainius Martuzevičius","doi":"10.1002/jbm.a.37798","DOIUrl":"https://doi.org/10.1002/jbm.a.37798","url":null,"abstract":"Regenerated fibrous cellulose possesses a unique set of properties, including biocompatibility, biodegradability, and high surface area potential, but its applications in the biomedical sector have not been sufficiently explored. In this study, nanofibrous cellulose matrices were fabricated via a wet-electrospinning process using a binary system of the solvent ionic liquid (IL) 1-butyl-3-methylimidazolium acetate (BMIMAc) and co-solvent dimethyl sulfoxide (DMSO). The morphology of the matrices was controlled by varying the ratio of BMIMAc versus DMSO in the solvent system. The most effective ratio of 1:1 produced smooth fibers with diameters ranging from 200 to 400 nm. The nanofibrous cellulose matrix showed no cytotoxicity when tested on mouse fibroblast L929 cells whose viability remained above 95%. Human triple-negative breast cancer MDA-MB-231 cells also exhibited high viability even after 7 days of seeding and were able to penetrate deeper layers of the matrix, indicating high biocompatibility. These properties of nanofibrous cellulose demonstrate its potential for tissue engineering and cell culture applications.","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High hydrostatic pressure treatment for advanced tissue grafts in reconstructive head and neck surgery.","authors":"Friederike Kalle,Valentin Paul Stadler,Julia Kristin Brach,Vivica Freiin Grote,Christopher Pohl,Karoline Schulz,Michael Seidenstuecker,Anika Jonitz-Heincke,Rainer Bader,Robert Mlynski,Daniel Strüder","doi":"10.1002/jbm.a.37791","DOIUrl":"https://doi.org/10.1002/jbm.a.37791","url":null,"abstract":"The increasing importance of regenerative medicine has resulted in a growing need for advanced tissue replacement materials in head and neck surgery. Allo- and xenogenic graft processing is often time-consuming and can deteriorate the extracellular matrix (ECM). High hydrostatic pressure (HHP)-treatment could allow specific devitalization while retaining the essential properties of the ECM. Porcine connective tissue and cartilage were HHP-treated at 100-400 MPa for 10 min. Structural modifications following HHP-exposure were examined using electron microscopy, while devitalization was assessed through metabolism and cell death analyses. Furthermore, ECM alterations and decellularization were evaluated by histology, biomechanical testing, and DNA content analysis. Additionally, the inflammatory potential of HHP-treated tissue was evaluated in vivo using a dorsal skinfold chamber in a mouse model. The devitalization effects of HHP were dose-dependent, with a threshold identified at 200 MPa for fibroblasts and chondrocytes. At this pressure level, HHP induced structural alterations in cells, with a shift toward late-stage apoptosis. HHP-treatment preserved ECM structure and biomechanical properties, but did not remove cell debris from the tissue. This study observed a pressure-dependent increase of markers suggesting the occurrence of immunogenic cell death. In vivo investigations revealed an absence of inflammatory responses to HHP-treated tissue, indicating a favorable biological response to HHP. In conclusion, application of HHP devitalizes fibroblasts and chondrocytes at 200 MPa while retaining the essential properties of the ECM. Prospectively, HHP may simplify the preparation of allo- and xenogenic tissue replacement materials and increase the availability of grafts in head and neck surgery.","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrospun poly(ε-caprolactone)/poly(glycerol sebacate) aligned fibers fabricated with benign solvents for tendon tissue engineering.","authors":"Francesco Iorio,Mohammad El Khatib,Natalie Wöltinger,Maura Turriani,Oriana Di Giacinto,Annunziata Mauro,Valentina Russo,Barbara Barboni,Aldo R Boccaccini","doi":"10.1002/jbm.a.37794","DOIUrl":"https://doi.org/10.1002/jbm.a.37794","url":null,"abstract":"The electrospinning technique is a commonly employed approach to fabricate fibers intended for various tissue engineering applications. The aim of this study is to develop a novel strategy for tendon repair through the use of aligned poly(ε-caprolactone) (PCL) and poly(glycerol sebacate) (PGS) fibers fabricated in benign solvents, and further explore the potential application of PGS in tendon tissue engineering (TTE). The fibers were characterized for their morphological and physicochemical properties; amniotic epithelial stem cells (AECs) were used to assess the fibers teno-inductive and immunomodulatory potential due to their ability to teno-differentiate undergoing first a stepwise epithelial to mesenchymal transition, and due to their documented therapeutic role in tendon regeneration. The addition of PGS to PCL improved the spinnability of the polymer solution, as well as the uniformity and directionality of the so-obtained fibers. The mechanical properties were in the range of most TTE applications, specifically in the case of PCL/PGS 4:1 and 2:1 ratios. Compared to PCL alone, the same ratios also allowed a better AECs infiltration and growth over 7 days of culture, and triggered the activation of tendon-related genes (SCX, COL1, TNMD) and the expression of tenomodulin (TNMD) at the protein level. Concerning the immunomodulatory properties, both PCL and PCL/PGS fibers negatively affected the immunomodulatory profile of AECs, up-regulating both anti-inflammatory (IL-10) and pro-inflammatory (IL-12) cytokines over 7 days of culture. Overall, PCL/PGS 2:1 fibers fabricated with benign solvents proved to be the most suitable composition for TTE application based on their topographical cues, mechanical properties, biocompatibility, and teno-inductive properties.","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of macrophage subtype-specific cytokines on fibroblast proliferation and endothelial cell function in co-culture system.","authors":"Ilaha Isali,Phillip McClellan,Thomas R Wong,Sara Hijaz,David R Fletcher,Guiming Liu,Tracey L Bonfield,James M Anderson,Adonis Hijaz,Ozan Akkus","doi":"10.1002/jbm.a.37799","DOIUrl":"https://doi.org/10.1002/jbm.a.37799","url":null,"abstract":"Macrophages are involved in several critical activities associated with tissue repair and regeneration. Current approaches in regenerative medicine are focusing on leveraging the innate immune response to accelerate tissue regeneration and improve long-term healing outcomes. Of particular interest in this regard are the currently known, four main M2 macrophage subtypes: M2interleukin (IL)-4,IL-13, M2IC, M2IL-10, M2non-selective adenosine receptor agonists (NECA) (M2IL-4,IL-13 → M2NECA). In this study, rat bone marrow-derived macrophages (M0) were polarized to each of the four subtypes M2IL-4,IL-13 → M2NECA and cultured for 72 h in vitro. Luminex assay results highlighted increased production of tissue inhibitor of metalloproteinases-1 (TIMP-1) for M2IL-4,IL-13, higher amounts of transforming growth factor-beta 1 (TGF-β1) for M2IL-10, and elevated vascular endothelial growth factor A (VEGF-A) from M2NECA. Co-culture experiments performed with M2IL-10 macrophages and L929 fibroblasts highlighted the increased production of soluble collagen within the media as well as higher amounts of collagen in the extracellular matrix. Human umbilical vein endothelial cells (HUVECs) were co-cultured with M2NECA macrophages, which demonstrated an increase in intercellular adhesion molecule (ICAM) and platelet endothelial cell adhesion molecule (PECAM), as well as increased formation of endothelial tubes. The findings of this study emphasize a critical demand for further characterization and analyses of distinct M2 subtypes and careful selection of specific macrophage populations for regeneration of specific tissue types. The current, broad classification of \"M2\" may be sufficient in many general tissue engineering applications, but, as conditions are constantly in flux within the microenvironment in vivo, a higher degree of specificity and control over the initial M2 subtype could result in more consistent long-term outcomes where macrophages are utilized as part of an overall regenerative strategy.","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical impedance characterization and modelling of Ti‐Β implants","authors":"Paula Navarro, Miguel Barrera, Alberto Olmo, Yadir Torres","doi":"10.1002/jbm.a.37797","DOIUrl":"https://doi.org/10.1002/jbm.a.37797","url":null,"abstract":"Commercially pure titanium (c.p. Ti) and Ti6Al4V alloys are the most widely used metallic biomaterials in the biomedical sector. However, their high rigidity and the controversial toxicity of their alloying elements often compromise their clinical success. The use of porous β‐Titanium alloys is proposed as a solution to these issues. In this regard, it is necessary to implement economic, repetitive, and non‐destructive measurement techniques that allow for the semi‐quantitative evaluation of the chemical nature of the implant, its microstructural characteristics, and/or surface changes. This study proposes the use of simple measurement protocols based on electrical impedance measurements, correlating them with the porosity inherent to processing conditions (pressure and temperature), as well as the chemical composition of the implant. Results revealed a clear direct relationship between porosity and electrical impedance. The percentage and/or size of the porosity decrease with an increase in compaction pressure and temperature. Moreover, there is a notable influence of the frequency used in the measurements obtained. Additionally, the sensitivity of this measurement technique has enabled the evaluation of differences in chemical composition and the detection of intermetallics in the implants. For the first time in the literature, this research establishes relationships between stiffness and electrical impedance, using approximations and models for the observed trends. All the results obtained corroborate the appropriateness of the technique to achieve the real‐time characterization of Titanium implants, in an efficient and non‐invasive way.","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of multilayered artificial urethra graft for urethroplasty","authors":"Povilas Barasa, Egidijus Simoliunas, Aivaras Grybas, Ramune Zilinskaite‐Tamasauske, Darius Dasevicius, Milda Alksne, Ieva Rinkunaite, Andrius Buivydas, Emilija Baltrukonyte, Rimgaile Tamulyte, Ashwinipriyadarshini Megur, Gilvydas Verkauskas, Daiva Baltriukiene, Virginija Bukelskiene","doi":"10.1002/jbm.a.37796","DOIUrl":"https://doi.org/10.1002/jbm.a.37796","url":null,"abstract":"To enhance the treatment of patients' urethral defects, such as strictures and hypospadias, we investigated the potential of using artificial urethral tissue. Our study aimed to generate this tissue and assess its effectiveness in a rabbit model. Two types of bioprinted grafts, based on methacrylated gelatin‐silk fibroin (GelMA‐SF) hydrogels, were produced: acellular, as well as loaded with autologous rabbit stem cells. Rabbit adipose stem cells (RASC) were differentiated toward smooth muscle in the GelMA‐SF hydrogel, while rabbit buccal mucosa stem cells (RBMC), differentiated toward the epithelium, were seeded on its surface, forming two layers of the cell‐laden tissue. The constructs were then reinforced with polycaprolactone‐polylactic acid meshes to create implantable multilayered artificial urethral grafts. In vivo experiments showed that the cell‐laden tissue integrated into the urethra with less fibrosis and inflammation compared to its acellular counterpart. Staining to trace the implanted cells confirmed integration into the host organism 3 months postsurgery.","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocrosslinkable hydrogel of ibuprofen-chitosan methacrylate modulates inflammatory response","authors":"Xiangheng Guan,&nbsp;Haochen Yao,&nbsp;Jinglei Wu","doi":"10.1002/jbm.a.37758","DOIUrl":"10.1002/jbm.a.37758","url":null,"abstract":"<p>Methacrylated biopolymers are unique and attractive in preparing photocrosslinkable hydrogels in biomedical applications. Here we report a novel chitosan (CS) derivative-based injectable hydrogel with anti-inflammatory capacity via methacrylation modification. First, ibuprofen (IBU) was conjugated to the backbone of CS by carbodiimide chemistry to obtain IBU-CS conjugate, which converts water-insoluble unmodified CS into water-soluble IBU-CS conjugate. The IBU-CS conjugate did not precipitate at the pH of 7, which was beneficial to subsequent chemical modification with methacrylic anhydride to prepare IBU-CS methacrylate (IBU-CS-MA) with significantly higher methacrylation substitution. Photocrosslinkable in situ gel formation of injectable IBU-CS-MA hydrogel was verified using lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator under visible light. The IBU-CS-MA hydrogel showed good cytocompatibility as revealed by encapsulating and in vitro culturing murine fibroblasts within hydrogels. It promoted macrophage polarization toward M2 phenotype, as well as downregulated pro-inflammatory gene expression and upregulated anti-inflammatory gene expression of macrophages. The hydrogel also significantly reduced the reactive oxygen specifies (ROS) and nitrogen oxide (NO) produced by lipopolysaccharides (LPS)-stimulated macrophages. Upon subcutaneous implantation in a rat model, it significantly mitigated inflammatory responses as shown by significantly lower inflammatory cell density, less cell infiltration, and much thinner fibrous capsule compared with CS methacrylate (CS-MA) hydrogel. This study suggests that IBU-CS conjugate represents a feasible strategy for preparing CS-based methacrylate hydrogels for biomedical applications.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and characterization of antacid microcapsules to buffer the acidic intervertebral disc microenvironment","authors":"Jennifer Gansau,&nbsp;Emily E. McDonnell,&nbsp;Conor T. Buckley","doi":"10.1002/jbm.a.37755","DOIUrl":"10.1002/jbm.a.37755","url":null,"abstract":"<p>During intervertebral disc (IVD) degeneration, microenvironmental challenges such as decreasing levels of glucose, oxygen, and pH play crucial roles in cell survival and matrix turnover. Antacids, such as Mg(OH)₂ and CaCO₃, entrapped in microcapsules are capable of neutralizing acidic microenvironments in a controlled fashion and therefore may offer the potential to improve the acidic niche of the degenerated IVD and enhance cell-based regeneration strategies. The objectives of this work were, first, to develop and characterize antacid microcapsules and assess their neutralization capacity in an acidic microenvironment and, second, to combine antacid microcapsules with cellular microcapsules in a hybrid gel system to investigate their neutralization effect as a potential therapeutic in a disc explant model. To achieve this, we screened five different pH- neutralizing agents (Al(OH)₃, Mg(OH)₂, CaCO₃, and HEPES) in terms of their pH neutralization capacities, with Mg(OH)₂ or CaCO₃ being carried forward for further investigation. Antacid-alginate microcapsules were formed at different concentrations using the electrohydrodynamic spraying process and assessed in terms of size, buffering kinetics, cell compatibility, and cytotoxicity. Finally, the combination of cellular microcapsules and antacid capsules was examined in a bovine disc explant model under physiological degenerative conditions. Overall, CaCO₃ was found to be superior in terms of neutralization capacities, release kinetics, and cellular response. Specifically, CaCO₃ elevated the acidic pH to neutral levels and is estimated to be maintained for several weeks based on Ca²⁺ release. Using a disc explant model, it was demonstrated that CaCO₃ microcapsules were capable of increasing the local pH within the core of a hybrid cellular gel system. This work highlights the potential of antacid microcapsules to positively alter the challenging acidic microenvironment conditions typically observed in degenerative disc disease, which may be used in conjunction with cell therapies to augment regeneration.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37755","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of bupivacaine-loaded gelatin-based hydrogel delivery system for sciatic nerve block in mice","authors":"Qunfei Zhang,&nbsp;Xiang Liu,&nbsp;Hongqiang Liu,&nbsp;Shufen Li,&nbsp;Zhenping An,&nbsp;Zujian Feng","doi":"10.1002/jbm.a.37754","DOIUrl":"10.1002/jbm.a.37754","url":null,"abstract":"<p>Peripheral nerve blockade (PNB) is a common treatment to relieve postoperative pain. However, local anesthetics alone have a short duration of action and severe side effects during postoperative analgesia. In order to overcome these limitations, the present study reported an injectable hydrogel with a drug slow-release profile for regional nerve blockade. The injectable hydrogel was prepared by crosslinking with gelatin and NHS-PEG-NHS, which was degradable in the physiological environment and displayed sustainable release of anesthetics locally, thus improving the disadvantage of the high toxicity of local anesthetics. In this regard, we conducted a series of in vitro characterizations and proved that the hydrogel has a porous three-dimensional mesh structure with high drug loading capability, and sustainable drug release profile. And cytotoxicity experiments confirmed the good biocompatibility of the hydrogel. It was shown that using the animal sciatic nerve block model, the analgesic effect was greatly improved in vivo, and there was no obvious evidence of permanent inflammation or nerve damage in the block site's sections. This locally slow-release platform, combined with local anesthetics, is therefore a promising contender for long-acting analgesia.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dedication: JBMR-A special edition recognizing James M. Anderson, M.D., Ph.D.","authors":"Nicholas P. Ziats,&nbsp;Elizabeth Cosgriff-Hernandez","doi":"10.1002/jbm.a.37733","DOIUrl":"10.1002/jbm.a.37733","url":null,"abstract":"<p>This special edition of the Journal of Biomedical Materials Research-Part A is dedicated to the past Editor-in Chief, Dr. James M. Anderson. This compilation of papers from former students, mentees, and colleagues in the biomaterial's community is a tribute to Dr. Anderson's outstanding contributions and leadership in the biomaterials field.</p><p>James Morley Anderson (photographs) was born in Eau Claire, Wisconsin, the son of Arnold and Evelyn Anderson and the brother of Richard, Evelyn, Ray, Kay, and Lyman. He graduated from Wisconsin State University at Eau Claire with a B.S. in Chemistry and then went on to receive his Ph.D. in Organic Chemistry from Oregon State University. He then moved to Cleveland, Ohio, to take a position as a Research Associate at Case Western Reserve University (CWRU), in the Division of Macromolecular Science and later entered their medical school and received his M.D. degree, followed by a Residency in Pathology at University Hospitals of Cleveland. Dr. Anderson then became an Assistant Professor of Pathology, rose to the rank of full Professor, became a Distinguished University Professor in 2012, and in 2023, he became Emeritus Professor. During this time, he also devoted clinical effort to the surgical pathology of medical devices and implants as well as developing a research career spanning over 50 years at CWRU. Dr. Anderson currently resides in Cleveland, Ohio, with his spouse, Mary Lou. Further details of his accomplishments at Case Western Reserve University can be found in a recent review published in Biomaterials Forum, Official Newsletter of the Society For Biomaterials, Volume 44(3);12–16, 2022, “Biomaterials at CWRU: the First 30+ Years by James Anderson.”</p><p>In addition to his numerous NIH funded research grants, Dr. Anderson has been the recipient of a NIH/NHLBI Research Career Development Award (1980–1985) and a NIH/NHLBI MERIT Award (1993–2003). He has over 400 peer-reviewed publications, 100 published book chapters, and an “H-index” greater than 100. Regarding his research support, Dr. Anderson received his first NIH R01 grant in 1970 and his last currently funded project was in 2016. His research interests have been numerous with a large breath and scope in biomaterials research and include studying polyamino acids: their synthesis and mechanism of polymerization as related to their biological activity, polymeric sustained release systems for pharmaceuticals, and other biologically active agents, biodegradable polymers—their structure–property relationships and their role in mechanism and rate of biodegradation, biocompatibility of biosensors, implant retrieval and evaluation, cardiovascular biomaterials including pathogenesis of prosthetic valve endocarditis and human vascular grafts and the blood/materials interaction, bacteria/blood/biomaterial interactions, and the mechanisms of monocyte/macrophage/foreign body giant cell adhesion and activation on biomedical polymers. A constant theme th","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}