Journal of biomedical materials research. Part A最新文献

{"title":"Intelligent Sensing Switches in Drug Delivery Systems: Mechanisms, Material Selection, and Future Perspectives","authors":"Fuyu Chen,&nbsp;Heng Li,&nbsp;Chengdong Zhen,&nbsp;Guimei Lin,&nbsp;Bingtao Tang,&nbsp;Yanbin Shi,&nbsp;Li Wang,&nbsp;Jinwei Qiao,&nbsp;Xuelin Li","doi":"10.1002/jbm.a.37938","DOIUrl":"https://doi.org/10.1002/jbm.a.37938","url":null,"abstract":"<div>\u0000 \u0000 <p>The intelligence and controllability of drug delivery systems (DDS) are crucial for enhancing therapeutic efficacy and minimizing side effects. Among these, DDS responsive switches play a pivotal role in precisely regulating the timing and spatial distribution of drug release in response to specific physiological environments within the body or external stimuli. Based on the origin of stimuli, they can be categorized into endogenous and exogenous stimuli. This paper reviews various types of stimulus-responsive switches, including dual-stimulus responsive switches, and elaborates on the drug release mechanisms of each intelligent switch. It summarizes the advantages and limitations of different stimulus-responsive systems, highlights the properties of commonly used temperature-sensitive materials, and discusses the applications of popular nano-engineered materials in pH and electromagnetic-responsive switches. Finally, the paper provides an outlook on the future of DDS, focusing on achieving more precise control, as well as ensuring clinical stability and reliability.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Mechanical Properties of Pituitary Adenomas for Optimized Surgery","authors":"Umesh Gautam,&nbsp;Hemlata Jangir,&nbsp;Harsh Jain,&nbsp;Vaishali Suri,&nbsp;Ajay Garg,&nbsp;Sitikantha Roy,&nbsp;Ashish Suri","doi":"10.1002/jbm.a.37940","DOIUrl":"https://doi.org/10.1002/jbm.a.37940","url":null,"abstract":"<div>\u0000 \u0000 <p>Pituitary adenoma (PA) is a common brain tumor located in a small cavity at the cranial base. It disrupts hormonal balance and compresses the optic nerves, leading to abnormal body growth, sexual dysfunction, vision loss, and mortality if untreated. Its surgical resection is highly challenging due to its small size, heterogeneous structure, deep location, and indistinct interface with surrounding nerves, arteries, and brain tissues. Mechanical properties of tumor tissues play a crucial role in their microstructure, growth, and progression. However, data on the mechanical properties of PA tissues is scarce. This study aims to provide detailed mechanical properties of various PA tissues and demonstrate the differences in stiffness between tumors and brain tissues. The viscoelastic properties and collagen content of postoperative PA tissues (<i>n</i> = 40) and normal human brain white matter (<i>n</i> = 7) were analyzed using in vitro nanoindentation and histological staining, respectively. Tumor consistency was also assessed preoperatively via magnetic resonance images (MRIs) and intraoperatively through surgeon feedback. PA tissues exhibited a considerable variation in viscoelastic properties; however, their average stiffness was significantly higher than normal brain white matter (<i>p</i> &lt; 0.05). Tumors with firm consistency showed higher collagen content (29.8% <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation>$$ pm $$</annotation>\u0000 </semantics></math> 21.2%) than the soft (9.1% <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation>$$ pm $$</annotation>\u0000 </semantics></math> 8.1%) and medium (12.9% <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation>$$ pm $$</annotation>\u0000 </semantics></math> 9.7%) consistency tumors, however the correlation with mechanical properties was not strong (<i>r</i> = 0.40, <i>p</i> = 0.01). Strong correlations between preoperative predictions, intraoperative observations, and postoperative measurements emphasize the clinical relevance of these findings. These results underscore the potential of mechanical biomarkers to enhance surgical strategies, improve outcomes, and support applications in diagnosis, development of elastography and elastic image fusion algorithms, as well as in robot-assisted interventions.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Application of Zeolitic Imidazolate Framework-8 Loaded With Artemisia Argyi Essential Oil in the Treatment of Bacterial Infected Wounds","authors":"Yiyang Xu,&nbsp;Ying Li,&nbsp;Zixuan Ye,&nbsp;Cheng Wang,&nbsp;Pengfei Cui,&nbsp;Shuwen Zhou,&nbsp;Lin Qiu,&nbsp;Jianhao Wang","doi":"10.1002/jbm.a.37937","DOIUrl":"https://doi.org/10.1002/jbm.a.37937","url":null,"abstract":"<div>\u0000 \u0000 <p>Wound bacterial infection deteriorates with antibiotic misuse, boosting bacterial drug resistance, threatening human health. Therefore, combining natural antibacterials with efficient broad-spectrum materials offers new solutions. Artemisia argyi is a kind of medicinal plant distributed in Asia, known for its rich biological active compounds. With the advancement of modern analytical technology, Artemisia argyi has shown excellent antibacterial and anti-inflammatory potential, particularly Artemisia argyi essential oil (AAEO) which is considered to be the most active substance in Artemisia argyi. However, its practical application is limited due to its poor water solubility, strong volatility, high sensitivity to light and heat, and its irritating odor. Zeolitic imidazolate framework-8 (ZIF-8) is a type of metal–organic framework material (MOF) with good biocompatibility, simple synthesis, high porosity, and antimicrobial activity. ZIF-8 can be used as an ideal vehicle for the preparation of antibacterial materials. In this study, we loaded AAEO onto ZIF-8 to successfully develop AAEO@ZIF-8 antibacterial nanomaterial. The bactericidal ability and antibacterial mechanism of AAEO@ZIF-8 were evaluated through in vitro experiments such as bacterial coating, Live/Dead staining, and crystal violet staining. It was confirmed that AAEO@ZIF-8 had significant antibacterial activity against both <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. In in vivo experiments, the wound model using C57BL/6 male mice was established, and wound tissue staining with Gram, CD31⁺ immunohistochemistry, H&amp;E, and Masson staining was performed to evaluate the antibacterial activity of AAEO@ZIF-8. The results showed that AAEO@ZIF-8 exhibited the best wound repair performance in the model. These findings suggested that AAEO@ZIF-8 is a novel and effective antimicrobial nanomaterial targeting pathogenic bacteria. This study successfully transformed the storage mode of AAEO from liquid to solid, providing a promising strategy for the application of AAEO in the treatment of wound bacterial infections.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3D Cell Culture Platform for Evaluating Macrophage-Liposome Conjugates in Combination Chemotherapy","authors":"Chia-Chen Kuo,&nbsp;Wei-Yu Liao,&nbsp;Yu-Jung Lin,&nbsp;Chau-Hwang Lee","doi":"10.1002/jbm.a.37939","DOIUrl":"https://doi.org/10.1002/jbm.a.37939","url":null,"abstract":"<div>\u0000 \u0000 <p>Macrophage-based drug delivery systems, such as macrophage-liposome conjugates (Mϕ-Lip), leverage the natural tumor-homing ability of macrophages and offer a potential solution for overcoming biological barriers and delivering chemotherapy drugs to challenging tumor regions. However, reliable platforms to assess the tumor-targeting efficiency, penetration capabilities, and therapeutic effectiveness of drug-laden macrophages remain largely unavailable. In this study, we developed a three-dimensional (3D) cell culture platform that mimics the structural and biological complexity of in vivo tumors, enabling real-time observation and analysis of Mϕ-Lip as they migrate, penetrate, and exert anti-tumor effects. Beyond evaluating the delivery process, this work focuses on the rational design and optimization of dosage regimens for co-delivering cisplatin (CDDP) and paclitaxel (Taxol) using Mϕ-Lip. Experimental results demonstrated that the drugs encapsulated within the liposomes influenced the invasive behavior of Mϕ-Lip, which in turn impacted their tumor-killing efficiency. Using this 3D cell culture platform, we identified optimal dosage regimens for co-delivering combination chemotherapy drugs through the Mϕ-Lip. This newly developed approach provides a reliable and versatile tool not only for evaluating but also for fine-tuning cell-based drug delivery strategies. It holds significant promise for advancing targeted chemotherapy strategies and improving therapeutic outcomes for solid tumors.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Dermatopontin-Collagen Nanocomposite for Accelerated Wound Healing and ECM Remodeling in Chronic Wound Conditions","authors":"Padmaja Murali,&nbsp;Anbuthiruselvan Solaimuthu,&nbsp;Purna Sai Korrapati","doi":"10.1002/jbm.a.37935","DOIUrl":"https://doi.org/10.1002/jbm.a.37935","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic cutaneous wounds are often accompanied by an extensive alteration in the standard extracellular matrix (ECM) architecture, leading to dysfunction of the resident cells and impaired healing. Conventional wound dressings often fail to address these complex tissue repair needs associated with chronic conditions. Here, we developed a biomimetic collagen-based scaffold, collagen/chitosan/MO NPs/DPT (CCMD), involving the skin-bridge protein dermatopontin (DPT) and molybdenum trioxide (MO NPs) nanoparticle in regulating the repairing cascades in chronic conditions. The sustained release of DPT increased cellular proliferation, cellular adhesion, wound contraction, and regulation of fibronectin in fibroblast cells. Furthermore, the CCMD in influencing angiogenesis was validated by the ex vivo and in vivo assays. The results revealed that the CCMD scaffold promoted endothelial sprouting and blood capillary density, signifying its pro-angiogenic potential and role in vascular reformation, which is ideal for tissue regeneration. Thus, our findings postulate that biomimetic CCMD could serve as a better dermal substrate for ECM reorganization and present new opportunities for pathological-relevant tissue repair in chronic environments.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Evaluation of an Elastic Decellularized Tendon-Derived Scaffold for Vascular Tissue Engineering Applications”","authors":"","doi":"10.1002/jbm.a.37934","DOIUrl":"https://doi.org/10.1002/jbm.a.37934","url":null,"abstract":"<p>S. Ghazanfari, K. A. Alberti, Q. Xu, and A. Khademhosseini, “Evaluation of an Elastic Decellularized Tendon-Derived Scaffold for Vascular Tissue Engineering Applications,” <i>Journal of Biomedical Materials Research Part A</i>, 107, no. 6 (2019): 1225–1234, https://doi.org/10.1002/jbm.a.36622.</p><p>We recently became aware of concerns regarding repetitive regions in Figure 3C. Unfortunately, the original image was not available, thus we proactively repeated the experiment to ensure the integrity of our data. The figure has now been replaced with a new image generated from independently repeated experiments. Please find the updated Figure 3 below:</p><p>In addition, we identified an assembly error in Figure 5A involving the misplacement of the representative image for SMCs on Day 3. Fortunately, we were able to identify the appropriate image from the original dataset. Please find the updated Figure 5 below:</p><p>Importantly, these corrections do not affect the interpretation of the data or alter the study's conclusions. We sincerely apologize for the error.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detachable Microneedles With Crosslinked Hyaluronic Acid as Superficial Skin Filler","authors":"Pattrawadee Toprangkobsin,&nbsp;Apasinee Teepakakorn,&nbsp;Supanan Ampawa,&nbsp;Ahmad Efendi,&nbsp;Benchaphorn Limcharoen,&nbsp;Wijit Banlunara,&nbsp;Pravit Asawanonda,&nbsp;Supason Wanichwecharungruang","doi":"10.1002/jbm.a.37933","DOIUrl":"https://doi.org/10.1002/jbm.a.37933","url":null,"abstract":"<div>\u0000 \u0000 <p>Crosslinking gives hyaluronic acid (HA) the ability to resist digestion by hyaluronidase; thus, crosslinked hyaluronic acid (cHA) is currently the most popular soft tissue filler. Clinically trained physicians usually administer cHA to the desired site via injections. Injection into the upper dermis and epidermis layers of the skin is challenging, and cHA with a low level of crosslinking is employed to prevent the uneven look, but it comes with a shorter lifetime. We demonstrate here the synthesis of cHA and its simultaneous fabrication into cHA-detachable microneedles (cHA-DDMNs). The cHA-DDMN patch allowed for the deposition of cHA into the ex vivo porcine skin in 1 min. The non-crosslinked HA placed into the ex vivo porcine skin spread out evenly within 30 min after it was applied. In contrast, the deposited cHA demonstrated prolonged localization in the tissue. Furthermore, we demonstrated the sustained release of curcumin delivered by cHA both in vitro and ex vivo. In rats, the administration of cHA-DDMNs to the skin did not cause skin irritation and led to a significant increase in dermal thickness and collagen deposition.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End of Life Biocompatibility Assessment for Chronically Implanted Cardiac Leads","authors":"Eric K. Long,&nbsp;Joseph F. Hassler,&nbsp;David M. Saylor,&nbsp;Ioan P. I. Gitsov,&nbsp;Logan Jolliffe,&nbsp;Augie Witkowski,&nbsp;Julie A. Alkatout,&nbsp;Greg Haugstad,&nbsp;Kimberly A. Chaffin","doi":"10.1002/jbm.a.37932","DOIUrl":"https://doi.org/10.1002/jbm.a.37932","url":null,"abstract":"<p>Medical devices should be biocompatible throughout the entire lifecycle, but the evaluation for biocompatibility is typically performed on a new, fully finished device. While long-term implantable devices such as cardiac leads maintain function for more than a decade, studies have not addressed changes in extractable species throughout the implant life cycle. In this study, we performed extractables analysis on cardiac leads that were implanted in humans for times ranging from 3 to 130 months. The exhaustive extracts were analyzed using liquid chromatography coupled to mass spectrometry to identify and relatively quantify extractable species. Over implant times exceeding a decade, no new species were formed, and the quantity of each class of mobile species remained constant or decreased over time. Polyurethane oligomers, a byproduct of the polymerization route, generally remained at constant levels, suggesting that there is little to no driving force for them to enter the surrounding tissue. Small molecule additives, such as the antioxidant Irganox 1076, contained within the polyurethane outer coating, decreased at a rate that was consistent with diffusional release rather than reactive consumption. These results support two important conclusions. First, the chemical profile of the mobile species does not change over the implanted lifecycle, indicating the biocompatibility of durable cardiac leads does not change over time. Second, the toxicological assumption that all mobile species identified in exhaustive extractions of a new device are released upon implant is extremely conservative when contrasted with the diffusional release rates measured in the human explanted leads studied herein.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37932","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezo1 Is an Early Mediator During Topography-Stimulated Osteogenic Differentiation of Bone Mesenchymal Stem Cells","authors":"Zhaojun Wu,&nbsp;Wenqing Hou,&nbsp;Jiachen Lu,&nbsp;Haoyu Zhao,&nbsp;Song Chen,&nbsp;Tailin Guo,&nbsp;Tingting Li","doi":"10.1002/jbm.a.37931","DOIUrl":"https://doi.org/10.1002/jbm.a.37931","url":null,"abstract":"<div>\u0000 \u0000 <p>Micro/nano-topographies (MNTs) of biomaterials are well-known to influence osteoblast differentiation, although the underlying mechanisms remain incompletely understood. Piezo1 is involved in mechanotransduction in various cell types, and we hypothesized that Piezo1 may play a key role in osteogenic differentiation through the NFATc1-Wnt/β-catenin or YAP signaling pathways. To test this hypothesis, polished titanium plates (PT) and titanium plates with TiO₂ nanotubes (TNT-30 and TNT-100) were used. Experimental results showed that TNT-100 increased the gene expression and activation of Piezo1, upregulating osteogenic genes such as NFATc1, Wnt3a, and β-catenin, and promoting the nuclear localization of NFATc1, β-catenin, and YAP compared to PT. The influx of Ca²⁺ through Piezo1, activated by MNTs, initiated the signaling cascades. Furthermore, compared to TRPV4, another recently reported mediator in MNTs-stimulated osteogenic differentiation, Piezo1 responded to MNTs much faster. These findings suggest that Piezo1 acts as an early mediator of osteogenic differentiation stimulated by MNTs in BMSCs.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilayer Electrospun Polyurethane Membrane With Tunable Elastomeric Properties for the Treatment of Congenital Diaphragmatic Hernia","authors":"Rodolphe Migneret,&nbsp;Guillaume Leks,&nbsp;Julie Favre,&nbsp;Emeline Lobry,&nbsp;Hamdi Jmal,&nbsp;Guy Schlatter,&nbsp;Isabelle Talon,&nbsp;Nadia Bahlouli,&nbsp;Anne Hébraud","doi":"10.1002/jbm.a.37926","DOIUrl":"https://doi.org/10.1002/jbm.a.37926","url":null,"abstract":"<p>Congenital diaphragmatic hernia is a rare condition characterized by the development of a defect in the diaphragm during early embryogenesis. For the most severe cases, when the diaphragmatic defect is large, the gap is currently closed by a prosthetic patch made of e-PTFE (Gore-Tex) materials, which lack sufficient elasticity, causing early rupture of stitches and subsequent hernia recurrence. In this study, we introduce a novel thermoplastic polyurethane membrane designed to accommodate the child's growth. This film/fiber bilayer membrane, produced in a single continuous electrospinning process by varying the flow rate, exhibits a smooth surface to prevent adhesion of the tissues on the abdominal side and a rough surface to promote adhesion of the diaphragm muscle on the thoracic side. Mechanical properties of the membrane were evaluated under various deformation modes, including uniaxial tensile tests and equibiaxial tensile tests by the bubble inflation technique. We demonstrated the ability to tune the elastic modulus by adjusting the thickness of the film and fibers, achieving greater stretchability than specified for supporting child growth and respiration both in uniaxial and inflation tests. Moreover, in vitro biological tests showed that the membrane promotes cellular colonization without pro-inflammatory effect, making it a promising candidate to replace the currently used prosthesis.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}