Ke Wang, Jue Zhang, Bing Han, Youyou Xu, Jiayue Xu, Fuhong Yuan, Lei Wang, Jianwei Zhu
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引用次数: 0
Abstract
Diabetic wound ulcers, characterized by chronic infection and persistent inflammation, significantly impair patient quality of life and present substantial socioeconomic burdens. Traditional therapeutic strategies frequently encounter challenges, including antibiotic resistance, systemic side effects, and inadequate control over localized inflammation. We herein developed novel carrier-free nanoparticles (CeCur NPs) by self-assembling chlorin e6 (Ce6) and curcumin, achieving simultaneous photodynamic antibacterial activity and sustained anti-inflammatory effects. CeCur NPs exhibited effective and synergetic anti-bacteria and anti-inflammation both in vitro and in vivo. Comprehensive biosafety evaluations further confirmed the excellent biocompatibility of CeCur NPs, underscoring their potential as a promising therapeutic strategy for accelerating diabetic wound healing.
期刊介绍：
The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device.
The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials.
Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.
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