Journal of biomedical materials research. Part A最新文献

{"title":"Correction to “Injectable Hydrogel Scaffold Incorporating Microspheres Containing Cobalt-Doped Bioactive Glass for Bone Healing”","authors":"","doi":"10.1002/jbm.a.37910","DOIUrl":"https://doi.org/10.1002/jbm.a.37910","url":null,"abstract":"<p>\u0000 <span>Ghiasi Tabari, P</span>, <span>Sattari, A</span>, <span>Mashhadi Keshtiban, M</span>, <span>Karkuki Osguei, N</span>, <span>Hardy, JG</span>, <span>Samadikuchaksaraei, A.</span> <span>Injectable Hydrogel Scaffold Incorporating Microspheres Containing Cobalt-Doped Bioactive Glass for Bone Healing</span>. <i>J Biomed Mater Res A.</i> <span>2024</span>, <span>112</span>(<span>12</span>): <span>2225</span>–<span>2242</span>; doi: https://doi.org/10.1002/jbm.a.37773.\u0000 </p><p>In Figure 4, panel A-S-G7Co of Alizarin Red S staining in our original article, an incorrect figure was used. Figure 4 is now updated with new correct panel for A-S-G7Co of Alizarin Red S staining. Please note that this correction does not affect the results, the description and interpretation of the results, or the conclusions of the article.</p><p>We apologize for this error.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical Assessment of the Galvanic Corrosion and Metal Ion Release in Overlapping Stent and Vascular Plug Systems","authors":"O. Burak Istanbullu,&nbsp;Gulsen Akdogan,&nbsp;Halis Yilmaz,&nbsp;Mustafa Istanbullu","doi":"10.1002/jbm.a.37946","DOIUrl":"https://doi.org/10.1002/jbm.a.37946","url":null,"abstract":"<p>Cardiovascular diseases cause the highest global mortality rates and are often treated with surgical interventions such as stent or vascular plug placement. However, in-stent restenosis develops over time depending on the material composition and interactions with body fluids. Current strategies to address restenosis include balloon angioplasty or placing a secondary stent at the same site. A key concern with overlapping stents is the increasing risk of galvanic corrosion, as most cardiovascular stents have metallic composition. This study examines galvanic corrosion rates in different vascular stent and plug combinations using electrochemical corrosion characterization techniques. Three metallic vascular specimens with varying compositions are evaluated. The specimens are immersed in simulated body fluid at 37°C under individual and overlapping conditions. Electrochemical impedance spectroscopy and current density measurements, conducted via potentiostat, provide insights into the corrosion behavior of each specimen configuration. Additionally, inductively coupled plasma mass spectrometry quantifies metal ion release through SBF samples. Results show that combining dissimilar materials in overlapping placements significantly increases galvanic corrosion and metal ion release. The corrosion current density (<i>i</i>_corr) significantly increased from 11.75 μA/cm² in the individual bare-metallic stent to 522.3 μA/cm² in the stent-on-plug configuration. A similar increase was observed in the stent-on-stent configuration, with an <i>i</i>_corr of 132.6 μA/cm². These results corresponded with notable decreases in electrochemical impedance and polarization resistance, measured as low as 0.039 kΩ (<i>Z</i>_T) and 0.057 kΩ cm² (<i>R</i>_P) for the stent-on-plug system. Consequently, the calculated corrosion rate escalated to 2254 μm/year, with a mass loss reaching 42.22 mg/cm²·year. ICP-MS analysis supported these findings, showing the highest levels of metal ion release in the stent-on-plug configuration, with 23.86 ppm of Ni and 0.41 ppm of Cr. These findings highlight the importance of stent-material selection in reducing corrosion-related complications. Implementing material-specific strategies in secondary stent placement can lower the risks of inflammatory host response, stent failure, and their long-term effects.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37946","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tendon-Tissue Derived Monofilaments by Electrochemical Compaction: Production and Characterization","authors":"Phillip McClellan,&nbsp;Joohee Choi,&nbsp;Mikhail Nasrallah,&nbsp;Kathleen Lundberg,&nbsp;Ozan Akkus","doi":"10.1002/jbm.a.37948","DOIUrl":"https://doi.org/10.1002/jbm.a.37948","url":null,"abstract":"<p>Repair of tendon tissues remains a complex problem in orthopedic surgery. Tendon auto- and allografts are not utilized to the full extent of their capabilities due largely to the lack of porosity and availability of properly processed tendon stock. Cryomilling is often utilized to maximize surface area-to-volume while limiting alterations to native protein/gene structure. In this study, native tendons were isolated, cryomilled, and decellularized using a truncated protocol. The resulting decellularized tendon powder exhibited reduced DNA content of less than 15 ng/mg, indicating effective removal of cellular components. The resulting decellularized tendon “powder” was then subjected to mild acidic conditions to partially solubilize the collagen within the extracellular matrix to produce a solution that could be electrochemically compacted to generate aligned fibers. Proteomic analyses revealed the presence of tendon-related proteins (cartilage oligomeric protein, fibromodulin, lumican, biglycan, and tenascin c). Proteoglycans were present in tendon-derived thread (TDT) and largely absent in pure collagen threads, as visualized by safranin O and quantified by dimethylmethylene blue staining. Mesenchymal stem cells seeded and cultured for up to 14 days on collagen threads and TDTs exhibited similar expression of genes related to tendon tissue.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144299867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Reactions Induced by Bioactive Glass Air Abrasion of Titanium and Their Effects on Osteoblast Cellular Responses","authors":"Faleh Abushahba,&nbsp;Adrian Stiller,&nbsp;Sherif A. Mohamad,&nbsp;Nagat Areid,&nbsp;Leena Hupa,&nbsp;Terhi J. Heino,&nbsp;Pekka K. Vallittu,&nbsp;Timo O. Närhi","doi":"10.1002/jbm.a.37949","DOIUrl":"https://doi.org/10.1002/jbm.a.37949","url":null,"abstract":"<p>This study investigated the chemical events that occur when titanium (Ti) surfaces are treated with air particle abrasion (APA) using zinc-containing bioactive glass (ZnBG), followed by immersion in simulated body fluid (SBF) for up to 96 h. The impact of these changes on osteoblast cell viability, adhesion, and differentiation was evaluated. Sandblasted and acid-etched (SA) Ti disks were subjected to APA with ZnBG particles and then immersed in SBF from 8 to 96 h. Ion dissolution and characterization of ZnBG powder and Ti disks were conducted. Analyses of osteoblast viability, adhesion, and alkaline phosphatase (ALP) activity were performed on MC3T3-E1 cells cultured on control disks (SA-Ti), as well as on ZnBG abraded disks (APA-Ti) and disks immersed for 96 h in SBF (CaP-Ti). After SBF immersion, the ZnBG particle surfaces showed a rise in Si atomic (at.)% within the first 8 h, while Ca remained stable, and the P doubled over 96 h. The ZnBG covering the disks dissolved during the first 8 h, and then the Ca, P, and Si at.% increased as the immersion time extended. The glass particles exhibited amorphous calcium–phosphate (Ca–P) layer formation after 96 h. A significantly (<i>p</i> = 0.004) higher cell viability level was observed on day 7 on APA-Ti compared to SA-Ti disks, while no differences in osteoblast differentiation were observed across the different surfaces. Fluorescence images demonstrated that on day 3, cells adhered to valleys and peaks of CaP-Ti threads but only to valleys on SA-Ti and APA-Ti disks. By day 7, cells were also observed on APA-Ti peaks but not on SA-Ti. In summary, APA enhanced osteoblast proliferation, and a biocompatible Ca–P layer, which formed upon mineralization, supported osteoblast viability, adhesion, and spreading.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37949","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tyrosine-Derived Polymeric Surfactants Modulate the Fusion of Normal and Cancer Cells","authors":"David I. Devore,&nbsp;Dongming Sun,&nbsp;Iman Tadmori,&nbsp;Kim-phuong N. Le,&nbsp;Mariana R. N. Lima,&nbsp;Joachim Kohn","doi":"10.1002/jbm.a.37941","DOIUrl":"https://doi.org/10.1002/jbm.a.37941","url":null,"abstract":"<p>Plasma membrane fusion and resealing play essential roles in diverse biological processes, including embryogenesis, morphogenesis, tissue repair, and cancer metastasis. Certain polymeric surfactants, including poly(ethylene glycol) (PEG) and triblock poly(alkylene oxides) like Poloxamer 188 (P188), are known to modify cell membrane biophysical properties. This has enabled applications such as PEG fusion for severed nerves and P188-mediated muscle tissue repair. Similar to P188, tyrosine-derived triblock copolymers (TyPS) form self-assembled nanospheres that can reversibly insert into phospholipid monolayers and cell plasma membranes. The effects of phospholipid head group polarity on the insertion of TyPS into Langmuir phospholipid monolayers are examined here. The hydrophobic blocks of the polymeric surfactants are found to provide the primary driving force for insertion in the phospholipid membranes. The impact of the TyPS, PEG, and P188, alone and in combination, on membrane fusion in normal (L929 mouse fibroblast) and transformed (MDA-MB-231 human breast cancer) cells is then determined using in vitro cell culture methods. The cell culture studies demonstrate that PEG induces fusion in both cell lines and reveal that the combination of PEG and P188 has a strong positive synergistic effect on cell fusion. In contrast, the TyPS exhibits strong anti-fusion properties, inhibiting both spontaneous and PEG-enhanced fusion. P188 has a weak antifusion effect compared to TyPS. The fusogenic or antifusogenic behaviors of the polymeric surfactants correlate with their thermodynamic Hansen solubility parameters, and the synthetic tunability of the TyPS enables access to a far greater range of hydrophobicities than the available commercial Poloxamers. These findings suggest that mixtures of PEG and P188 may have the potential to enhance tissue repair and hybridoma output for monoclonal antibody production, while the TyPS may have the potential to inhibit metastatic cancers.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37941","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Characterization of AgNWs Conductive Hydrogel With High Mechanical Performance, High Electrical Conductivity, and Biocompatibility","authors":"Shui Guan,&nbsp;Fengxu Wang,&nbsp;Chuzhou Wen,&nbsp;Hailong Liu,&nbsp;Changkai Sun","doi":"10.1002/jbm.a.37951","DOIUrl":"https://doi.org/10.1002/jbm.a.37951","url":null,"abstract":"<div>\u0000 \u0000 <p>Hydrogel scaffolds incorporating conductive fillers have garnered significant interest due to their potential applications in neural tissue repair and regenerative medicine. However, most conductive fillers have adverse effects on the mechanical properties of hydrogel networks. In the present study, a novel polyacrylamide/alginate (PAAm/Alg) assembled with conductive silver nanowires (AgNWs) composite hydrogel was developed through photopolymerization and crosslinking methods. The chemical structure, morphology, mechanical properties, conductivity, porosity, swelling rate, adhesive strength, thermal stability, in vitro biodegradation, and biocompatibility of the prepared hydrogel samples were investigated. The PAAm/Alg-AgNWs hydrogels exhibited uniform pore structure distribution, high porosity and water absorption, improved mechanical and conductive properties, good thermal stability, and adequate biodegradability. In particular, the 0.4 wt% AgNWs conductive hydrogel exhibited excellent conductivity of 0.618 S/m and a high Young's modulus of 43.6 kPa, along with good electrical durability and stability over ten cyclic loading. Moreover, the abundant hydrophilic groups in the hydrogel make it have good adhesion properties at different interfaces. Compared with the PAAm/Alg hydrogel, the incorporation of AgNWs enhanced the material's roughness, facilitating cell adhesion, viability, and proliferation. These results showed that the AgNWs assembled into the PAAm/Alg polymers endowed the hydrogel with high electrical conductivity, while excellent mechanical strength and biocompatibility, indicating an attractive conductive substrate for further studies on neural tissue repair and regeneration.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Evaluation of Mesoporous Silica-Biopolymer-Based Bone Substitutes for Tissue Engineering","authors":"María Inés Álvarez Echazu,&nbsp;Sandra Judith Renou,&nbsp;Christian Ezequiel Olivetti,&nbsp;Gisela Solange Alvarez,&nbsp;Martin Federico Desimone,&nbsp;Daniel Gustavo Olmedo","doi":"10.1002/jbm.a.37927","DOIUrl":"https://doi.org/10.1002/jbm.a.37927","url":null,"abstract":"<div>\u0000 \u0000 <p>Bone substitutes for tissue regeneration should provide an appropriate environment for cell attachment, differentiation, proliferation, and migration. 3D structure, degradability, swelling, porosity, and cytotoxicity have been highlighted as key points in their design. For this research, mesoporous silica-biopolymer composites were synthesized from mesoporous silica (Mes-Si) particles combined with either collagen (C/Mes-Si) or chitosan (CS/Mes-Si). The composites were evaluated for tissue engineering purposes, as bone substitutes intended to imitate features of the natural bone matrix, thereby providing an appropriate biochemical environment for bone repair. Physicochemical-biological evaluation was performed to identify the features that would be useful for bone tissue engineering. For the Mes-Si particles, the specific surface area was 750.95 m²/g and the average pore size was 3.47 nm. SEM images showed that Mes-Si particles were distributed within the chitosan (CS) or collagen (C) matrix. Both composites swelled rapidly and had low cytotoxicity. Histologically, no acute inflammatory infiltrate or giant multinucleated cell was observed 14 days after implantation. In C/Mes-Si, newly woven bone tissue and areas of osseointegration at the C/Mes-Si-tissue interface were observed. In CS/Mes-Si, only reparative granulation tissue was observed. The physicochemical properties and biocompatibility of both composites were adequate for a bone scaffold. Moreover, Mes-Si particles have a tunable surface area for chemical modifications and anchoring bioactive materials, which may enhance composite bioactivity or the delivery of bioactive materials.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Nanoparticle-Enhanced Silk Hydrogels for Tissue Engineering Biomaterials","authors":"Olivia K. Foster,&nbsp;Derek Hiscox,&nbsp;Sawnaz Shaidani,&nbsp;Jean Park,&nbsp;Ella Canas,&nbsp;Charlotte Jacobus,&nbsp;Riley Patten,&nbsp;David L. Kaplan","doi":"10.1002/jbm.a.37945","DOIUrl":"https://doi.org/10.1002/jbm.a.37945","url":null,"abstract":"<div>\u0000 \u0000 <p>Hydrogels prepared from natural polymers, such as silk fibroin, are useful in the field of tissue engineering due to their biocompatibility, biodegradability, and biological performance. However, poor mechanical properties can limit their broader utility. This study investigated reinforcing enzymatically crosslinked silk hydrogels with 130 nm silk nanoparticles (SNPs) to generate silk-silk composite materials with tunable strength and stiffness. The strength of the materials was dependent on SNP concentration, and hydrogels with Young's moduli of 14, 34, and 67 kPa were fabricated by adding no SNPs, 2 mg/mL SNPs, and 4 mg/mL SNPs, respectively. These methods were applied to silk bioinks using Freeform Reversible Embedding of Suspended Hydrogels (FRESH) 3D printing to fabricate complex 3D structures with control of elasticity and modulus. Cylinders with Young's moduli of 17, 35, and 58 kPa were obtained with no SNPs, 2 mg/mL SNPs, and 4 mg/mL SNPs, respectively. SNPs were also preloaded with epidermal growth factor (EGF), relevant for tissue development and wound healing, and sustained release was achieved for over 15 days when embedded in hydrogels. Pilot studies of dermal fibroblast encapsulation in SNP-reinforced silk hydrogels demonstrated cytocompatibility. Tunable silk hydrogels reinforced with SNPs provide application-specific scaffolding for a variety of biomaterial and tissue engineering applications.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsphere-Mediated Sustained Delivery of Growth Factors Stimulates Osteogenesis in Target Cells in a Three-Dimensional Microenvironment","authors":"Ketki Holkar,&nbsp;Prasad Pethe,&nbsp;Vaijayanti Kale,&nbsp;Ganesh Ingavle","doi":"10.1002/jbm.a.37947","DOIUrl":"https://doi.org/10.1002/jbm.a.37947","url":null,"abstract":"<div>\u0000 \u0000 <p>Efficient bone repair relies on both osteogenic and angiogenic signals, with growth factors playing a pivotal role. Despite decades of recognition of their therapeutic potential, the optimal dosages and delivery routes of growth factors still require extensive investigation. Previous research demonstrated the osteoinductive and angiogenic potential of growth factors. However, effective therapeutic outcomes depend on precise dosing and prolonged delivery. This study investigates the dual delivery of key growth factors, bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF), providing insights into their optimal dosages and delivery mechanisms. The combination of these growth factors may enhance scaffold-mediated bone regeneration in the early stages of healing. This study employed a dual delivery system using BMP-2 and VEGF, comparing two methods to determine the optimal dosage and delivery strategy. The combined effect indicates that sustained delivery is a more efficient method. Osteogenesis and angiogenesis were examined in an interpenetrating network (IPN) hydrogel composed of alginate and polyethylene diacrylate (PEGDA), which encapsulated preosteoblast MC3T3 cells. The findings of this study reveal significant increases in alkaline phosphatase (ALP) activity and calcium content, emphasizing the effectiveness of this approach. Biomaterial characterization, including swelling measurements, Fourier transform infrared (FTIR) spectroscopy, confirmed growth factor encapsulation, and a release assay validated the delivery process. Compared to direct delivery, sustained delivery increased ALP activity and calcium release by up to 1.12- and 1.85-fold, respectively. Molecular studies indicated that sustained delivery of both growth factors had a stronger osteoinductive and angiogenic effect than direct delivery. This research evaluates the effects of growth factor delivery in a 3D hydrogel-based microenvironment using hydrogels and compares delivery methods to identify a more effective strategy for bone healing.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing Next-Generation Biomaterials to Enhance Peripheral Nerve Repair and Reconstruction","authors":"Rachael Putman,&nbsp;Neill Li,&nbsp;Daniel Y. Joh,&nbsp;Stefan Roberts,&nbsp;Tyler Pidgeon,&nbsp;Suhail Mithani,&nbsp;Ashutosh Chilkoti","doi":"10.1002/jbm.a.37930","DOIUrl":"https://doi.org/10.1002/jbm.a.37930","url":null,"abstract":"<div>\u0000 \u0000 <p>Peripheral nerve injuries are a common and potentially devastating condition affecting over 20 million people in the United States alone, resulting in significant functional disability and chronic pain for patients. Unfortunately, even when repaired under optimal conditions with cutting-edge techniques, current approaches to peripheral nerve repair result in incomplete functional recovery and chronic pain in over half of patients, highlighting the pressing need for the development of new strategies for peripheral nerve repair. Biomaterials, due to their tunable properties, can be rationally designed to address many aspects of peripheral nerve repair, making them a promising solution for improving functional outcomes following nerve repair. This review discusses the current lack of efficacious treatments for peripheral nerve repair and how biomaterials can fill this crucial void, as well as what properties those materials should have from a material, biological, and practical concerns perspective. The review is divided into three main sections, the first of which outlines the complex process of peripheral nerve repair, providing an understandable and clinically germane overview of peripheral nerve repair. Part two of this review discusses biological design principles to engineer biomaterials that favor nerve regeneration. Part three discusses practical considerations for adapting biomaterials for clinical use.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}