Journal of biomedical materials research. Part A最新文献

{"title":"Assessment of the Use of Hybrid Film With Titanium Deposition on AISI 316-L Stainless Steel Substrate as a Biomaterial","authors":"Marielen Longhi,&nbsp;Lucas Pandolphi Zini,&nbsp;Vanessa Bueno Pereira,&nbsp;Natasha Maurmann,&nbsp;Patricia Pranke,&nbsp;Venina Santos,&nbsp;Jane Zoppas Ferreira","doi":"10.1002/jbm.a.37942","DOIUrl":"https://doi.org/10.1002/jbm.a.37942","url":null,"abstract":"<div>\u0000 \u0000 <p>Metals play a fundamental role in medicine, particularly in the replacement, stabilization, and reinforcement of human body structures, due to their excellent mechanical performance. However, the biocompatibility of these materials is a critical factor, as they must not induce adverse reactions or pathologies when in contact with bodily fluids, which could lead to implant rejection by the host organism. Among the widely used metals, AISI 316-L stainless steel (SS) stands out for its mechanical properties and lower cost but presents limitations related to corrosion in biological environments, leading to the release of nickel and chromium ions, which are harmful to the human body. A promising alternative to mitigate these effects is the use of biocompatible coatings. In this context, the present study aimed to develop and characterize different hybrid films on AISI 316-L SS substrates for medical applications. The coatings were based on the alkoxide precursors 3-(trimethoxysilylpropyl)methacrylate (MAP) and tetraethyl orthosilicate (TEOS), applied via dip-coating and followed by titanium thin film deposition through magnetron sputtering. The results indicated good interaction between the hybrid layer, the titanium thin film, and the substrate. The HF sample, composed of only one silane-based layer, exhibited the lowest surface roughness (16.7 ± 0.6 nm Ra) compared with pure AISI SS (27.3 ± 1 nm Ra), which positively influenced the contact angle, achieving a value of (69.1° ± 0.3°), promoting cell adhesion and osseointegration—key factors for the clinical success of implants. Surfaces coated with titanium for 10 and 20 min (HF_Ti10 and HF_Ti20) on AISI 316-L SS demonstrated contact angles similar to SS (83.4° ± 0.4°), indicating a hydrophilic behavior. Additionally, no cytotoxicity was observed in the coated samples compared with the control group after 14 days in lactate dehydrogenase (LDH) assays, and HF_Ti10 presented the lowest cytotoxicity. Adherent stem cells were found in all experimental groups. These findings suggest that pre-treatment with silane-based HF, followed by titanium thin film deposition, holds great potential for application in AISI 316-L SS materials in the medical field, contributing to the development of safe and effective implants.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144219952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell/Surface Interactions and Osseointegration of Ti-6AI-4V: Effects of Laser Microgrooves, Hydroxyapatite Nanorods, and Arginyl-Glycyl-Aspartic Acid (RGD) on Ti-6Al-4V","authors":"Precious O. Etinosa,&nbsp;Ali A. Salifu,&nbsp;Sarah A. Osafo,&nbsp;Stanley C. Eluu,&nbsp;John D. Obayemi,&nbsp;Winston O. Soboyejo","doi":"10.1002/jbm.a.37929","DOIUrl":"https://doi.org/10.1002/jbm.a.37929","url":null,"abstract":"<div>\u0000 \u0000 <p>This work presents the results of an experimental study of surface-modified Ti-6Al-4V designed to enhance implant integration with human fetal osteoblast (hFOB) cells. Three surface profiles—laser-grooved (LG), Hydroxyapatite (HA)-coated laser-grooved (LGH), and arginyl glycyl aspartic acid (RGD)-functionalized HA-coated laser-grooved (LGHR)—were developed and evaluated for their effects on hFOB cell attachment, spreading, proliferation, and ECM formation over a 28-day period. Cell-laden surfaces were analyzed using scanning electron and fluorescence microscopies, and cell proliferation was quantified using the Alamar Blue assay to provide additional insights. The surface characterization revealed that the LG substrate facilitated contact guidance, promoting directional cell alignment and attachment. The LGH substrate additionally created a bioactive interface by mimicking natural bone tissue, releasing calcium and phosphate ions that enhanced cell attachment and spreading. The LGHR substrate provided specific biological cues, further improving early cell attachment, accelerating proliferation, and promoting extracellular matrix (ECM) formation. Quantitative analysis confirmed that LGHR surfaces exhibited the highest cell density, areal coverage, and metabolic activity, particularly during the initial stages of culture, emphasizing the synergistic effects of HA and RGD coatings in accelerating osseointegration. This novel approach offers robust improvements in implant-tissue integration, accelerating wound healing and enhancing tissue compatibility, with promising implications for orthopedic and dental applications.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144206462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Simultaneous Linear Release of Folic Acid and Doxorubicin from Ethyl Cellulose/Chitosan/g-C3N4/MoS2 Core-Shell Nanofibers and its Anticancer Properties","authors":"","doi":"10.1002/jbm.a.37921","DOIUrl":"https://doi.org/10.1002/jbm.a.37921","url":null,"abstract":"<p>\u0000 <b>RETRACTION:</b> <span>A. Nouri</span>, <span>B. F. Dizaji</span>, <span>N. Kianinejad</span>, <span>A. J. Rad</span>, <span>S. Rahimi</span>, <span>M. Irani</span>, and <span>F. S. Jazi</span>, “ <span>Simultaneous Linear Release of Folic Acid and Doxorubicin from Ethyl Cellulose/Chitosan/g-C3N4/MoS2 Core-Shell Nanofibers and its Anticancer Properties</span>,” <i>Journal of Biomedical Materials Research Part A</i> <span>109</span>, no. <span>6</span> (<span>2021</span>): <span>903</span>–<span>914</span>, https://doi.org/10.1002/jbm.a.37081.\u0000 </p><p>The above article, published online on 09 August 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, J. Kent Leach; and Wiley Periodicals LLC. A third party notified the publisher that they had found evidence of image manipulation in Figures 6A, 6C, and 6D. An investigation by the publisher confirmed that elements in those figures had been copied and manipulated to compose each image. The retraction has been agreed due to the evidence of image manipulation which fundamentally compromises the conclusions presented in the article. The corresponding author Mohammad Irani disagrees with this decision. The other authors did not respond.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37921","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent Sensing Switches in Drug Delivery Systems: Mechanisms, Material Selection, and Future Perspectives","authors":"Fuyu Chen,&nbsp;Heng Li,&nbsp;Chengdong Zhen,&nbsp;Guimei Lin,&nbsp;Bingtao Tang,&nbsp;Yanbin Shi,&nbsp;Li Wang,&nbsp;Jinwei Qiao,&nbsp;Xuelin Li","doi":"10.1002/jbm.a.37938","DOIUrl":"https://doi.org/10.1002/jbm.a.37938","url":null,"abstract":"<div>\u0000 \u0000 <p>The intelligence and controllability of drug delivery systems (DDS) are crucial for enhancing therapeutic efficacy and minimizing side effects. Among these, DDS responsive switches play a pivotal role in precisely regulating the timing and spatial distribution of drug release in response to specific physiological environments within the body or external stimuli. Based on the origin of stimuli, they can be categorized into endogenous and exogenous stimuli. This paper reviews various types of stimulus-responsive switches, including dual-stimulus responsive switches, and elaborates on the drug release mechanisms of each intelligent switch. It summarizes the advantages and limitations of different stimulus-responsive systems, highlights the properties of commonly used temperature-sensitive materials, and discusses the applications of popular nano-engineered materials in pH and electromagnetic-responsive switches. Finally, the paper provides an outlook on the future of DDS, focusing on achieving more precise control, as well as ensuring clinical stability and reliability.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Mechanical Properties of Pituitary Adenomas for Optimized Surgery","authors":"Umesh Gautam,&nbsp;Hemlata Jangir,&nbsp;Harsh Jain,&nbsp;Vaishali Suri,&nbsp;Ajay Garg,&nbsp;Sitikantha Roy,&nbsp;Ashish Suri","doi":"10.1002/jbm.a.37940","DOIUrl":"https://doi.org/10.1002/jbm.a.37940","url":null,"abstract":"<div>\u0000 \u0000 <p>Pituitary adenoma (PA) is a common brain tumor located in a small cavity at the cranial base. It disrupts hormonal balance and compresses the optic nerves, leading to abnormal body growth, sexual dysfunction, vision loss, and mortality if untreated. Its surgical resection is highly challenging due to its small size, heterogeneous structure, deep location, and indistinct interface with surrounding nerves, arteries, and brain tissues. Mechanical properties of tumor tissues play a crucial role in their microstructure, growth, and progression. However, data on the mechanical properties of PA tissues is scarce. This study aims to provide detailed mechanical properties of various PA tissues and demonstrate the differences in stiffness between tumors and brain tissues. The viscoelastic properties and collagen content of postoperative PA tissues (<i>n</i> = 40) and normal human brain white matter (<i>n</i> = 7) were analyzed using in vitro nanoindentation and histological staining, respectively. Tumor consistency was also assessed preoperatively via magnetic resonance images (MRIs) and intraoperatively through surgeon feedback. PA tissues exhibited a considerable variation in viscoelastic properties; however, their average stiffness was significantly higher than normal brain white matter (<i>p</i> &lt; 0.05). Tumors with firm consistency showed higher collagen content (29.8% <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation>$$ pm $$</annotation>\u0000 </semantics></math> 21.2%) than the soft (9.1% <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation>$$ pm $$</annotation>\u0000 </semantics></math> 8.1%) and medium (12.9% <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation>$$ pm $$</annotation>\u0000 </semantics></math> 9.7%) consistency tumors, however the correlation with mechanical properties was not strong (<i>r</i> = 0.40, <i>p</i> = 0.01). Strong correlations between preoperative predictions, intraoperative observations, and postoperative measurements emphasize the clinical relevance of these findings. These results underscore the potential of mechanical biomarkers to enhance surgical strategies, improve outcomes, and support applications in diagnosis, development of elastography and elastic image fusion algorithms, as well as in robot-assisted interventions.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Application of Zeolitic Imidazolate Framework-8 Loaded With Artemisia Argyi Essential Oil in the Treatment of Bacterial Infected Wounds","authors":"Yiyang Xu,&nbsp;Ying Li,&nbsp;Zixuan Ye,&nbsp;Cheng Wang,&nbsp;Pengfei Cui,&nbsp;Shuwen Zhou,&nbsp;Lin Qiu,&nbsp;Jianhao Wang","doi":"10.1002/jbm.a.37937","DOIUrl":"https://doi.org/10.1002/jbm.a.37937","url":null,"abstract":"<div>\u0000 \u0000 <p>Wound bacterial infection deteriorates with antibiotic misuse, boosting bacterial drug resistance, threatening human health. Therefore, combining natural antibacterials with efficient broad-spectrum materials offers new solutions. Artemisia argyi is a kind of medicinal plant distributed in Asia, known for its rich biological active compounds. With the advancement of modern analytical technology, Artemisia argyi has shown excellent antibacterial and anti-inflammatory potential, particularly Artemisia argyi essential oil (AAEO) which is considered to be the most active substance in Artemisia argyi. However, its practical application is limited due to its poor water solubility, strong volatility, high sensitivity to light and heat, and its irritating odor. Zeolitic imidazolate framework-8 (ZIF-8) is a type of metal–organic framework material (MOF) with good biocompatibility, simple synthesis, high porosity, and antimicrobial activity. ZIF-8 can be used as an ideal vehicle for the preparation of antibacterial materials. In this study, we loaded AAEO onto ZIF-8 to successfully develop AAEO@ZIF-8 antibacterial nanomaterial. The bactericidal ability and antibacterial mechanism of AAEO@ZIF-8 were evaluated through in vitro experiments such as bacterial coating, Live/Dead staining, and crystal violet staining. It was confirmed that AAEO@ZIF-8 had significant antibacterial activity against both <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. In in vivo experiments, the wound model using C57BL/6 male mice was established, and wound tissue staining with Gram, CD31⁺ immunohistochemistry, H&amp;E, and Masson staining was performed to evaluate the antibacterial activity of AAEO@ZIF-8. The results showed that AAEO@ZIF-8 exhibited the best wound repair performance in the model. These findings suggested that AAEO@ZIF-8 is a novel and effective antimicrobial nanomaterial targeting pathogenic bacteria. This study successfully transformed the storage mode of AAEO from liquid to solid, providing a promising strategy for the application of AAEO in the treatment of wound bacterial infections.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3D Cell Culture Platform for Evaluating Macrophage-Liposome Conjugates in Combination Chemotherapy","authors":"Chia-Chen Kuo,&nbsp;Wei-Yu Liao,&nbsp;Yu-Jung Lin,&nbsp;Chau-Hwang Lee","doi":"10.1002/jbm.a.37939","DOIUrl":"https://doi.org/10.1002/jbm.a.37939","url":null,"abstract":"<div>\u0000 \u0000 <p>Macrophage-based drug delivery systems, such as macrophage-liposome conjugates (Mϕ-Lip), leverage the natural tumor-homing ability of macrophages and offer a potential solution for overcoming biological barriers and delivering chemotherapy drugs to challenging tumor regions. However, reliable platforms to assess the tumor-targeting efficiency, penetration capabilities, and therapeutic effectiveness of drug-laden macrophages remain largely unavailable. In this study, we developed a three-dimensional (3D) cell culture platform that mimics the structural and biological complexity of in vivo tumors, enabling real-time observation and analysis of Mϕ-Lip as they migrate, penetrate, and exert anti-tumor effects. Beyond evaluating the delivery process, this work focuses on the rational design and optimization of dosage regimens for co-delivering cisplatin (CDDP) and paclitaxel (Taxol) using Mϕ-Lip. Experimental results demonstrated that the drugs encapsulated within the liposomes influenced the invasive behavior of Mϕ-Lip, which in turn impacted their tumor-killing efficiency. Using this 3D cell culture platform, we identified optimal dosage regimens for co-delivering combination chemotherapy drugs through the Mϕ-Lip. This newly developed approach provides a reliable and versatile tool not only for evaluating but also for fine-tuning cell-based drug delivery strategies. It holds significant promise for advancing targeted chemotherapy strategies and improving therapeutic outcomes for solid tumors.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Dermatopontin-Collagen Nanocomposite for Accelerated Wound Healing and ECM Remodeling in Chronic Wound Conditions","authors":"Padmaja Murali,&nbsp;Anbuthiruselvan Solaimuthu,&nbsp;Purna Sai Korrapati","doi":"10.1002/jbm.a.37935","DOIUrl":"https://doi.org/10.1002/jbm.a.37935","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic cutaneous wounds are often accompanied by an extensive alteration in the standard extracellular matrix (ECM) architecture, leading to dysfunction of the resident cells and impaired healing. Conventional wound dressings often fail to address these complex tissue repair needs associated with chronic conditions. Here, we developed a biomimetic collagen-based scaffold, collagen/chitosan/MO NPs/DPT (CCMD), involving the skin-bridge protein dermatopontin (DPT) and molybdenum trioxide (MO NPs) nanoparticle in regulating the repairing cascades in chronic conditions. The sustained release of DPT increased cellular proliferation, cellular adhesion, wound contraction, and regulation of fibronectin in fibroblast cells. Furthermore, the CCMD in influencing angiogenesis was validated by the ex vivo and in vivo assays. The results revealed that the CCMD scaffold promoted endothelial sprouting and blood capillary density, signifying its pro-angiogenic potential and role in vascular reformation, which is ideal for tissue regeneration. Thus, our findings postulate that biomimetic CCMD could serve as a better dermal substrate for ECM reorganization and present new opportunities for pathological-relevant tissue repair in chronic environments.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Evaluation of an Elastic Decellularized Tendon-Derived Scaffold for Vascular Tissue Engineering Applications”","authors":"","doi":"10.1002/jbm.a.37934","DOIUrl":"https://doi.org/10.1002/jbm.a.37934","url":null,"abstract":"<p>S. Ghazanfari, K. A. Alberti, Q. Xu, and A. Khademhosseini, “Evaluation of an Elastic Decellularized Tendon-Derived Scaffold for Vascular Tissue Engineering Applications,” <i>Journal of Biomedical Materials Research Part A</i>, 107, no. 6 (2019): 1225–1234, https://doi.org/10.1002/jbm.a.36622.</p><p>We recently became aware of concerns regarding repetitive regions in Figure 3C. Unfortunately, the original image was not available, thus we proactively repeated the experiment to ensure the integrity of our data. The figure has now been replaced with a new image generated from independently repeated experiments. Please find the updated Figure 3 below:</p><p>In addition, we identified an assembly error in Figure 5A involving the misplacement of the representative image for SMCs on Day 3. Fortunately, we were able to identify the appropriate image from the original dataset. Please find the updated Figure 5 below:</p><p>Importantly, these corrections do not affect the interpretation of the data or alter the study's conclusions. We sincerely apologize for the error.</p>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.a.37934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detachable Microneedles With Crosslinked Hyaluronic Acid as Superficial Skin Filler","authors":"Pattrawadee Toprangkobsin,&nbsp;Apasinee Teepakakorn,&nbsp;Supanan Ampawa,&nbsp;Ahmad Efendi,&nbsp;Benchaphorn Limcharoen,&nbsp;Wijit Banlunara,&nbsp;Pravit Asawanonda,&nbsp;Supason Wanichwecharungruang","doi":"10.1002/jbm.a.37933","DOIUrl":"https://doi.org/10.1002/jbm.a.37933","url":null,"abstract":"<div>\u0000 \u0000 <p>Crosslinking gives hyaluronic acid (HA) the ability to resist digestion by hyaluronidase; thus, crosslinked hyaluronic acid (cHA) is currently the most popular soft tissue filler. Clinically trained physicians usually administer cHA to the desired site via injections. Injection into the upper dermis and epidermis layers of the skin is challenging, and cHA with a low level of crosslinking is employed to prevent the uneven look, but it comes with a shorter lifetime. We demonstrate here the synthesis of cHA and its simultaneous fabrication into cHA-detachable microneedles (cHA-DDMNs). The cHA-DDMN patch allowed for the deposition of cHA into the ex vivo porcine skin in 1 min. The non-crosslinked HA placed into the ex vivo porcine skin spread out evenly within 30 min after it was applied. In contrast, the deposited cHA demonstrated prolonged localization in the tissue. Furthermore, we demonstrated the sustained release of curcumin delivered by cHA both in vitro and ex vivo. In rats, the administration of cHA-DDMNs to the skin did not cause skin irritation and led to a significant increase in dermal thickness and collagen deposition.</p>\u0000 </div>","PeriodicalId":15142,"journal":{"name":"Journal of biomedical materials research. Part A","volume":"113 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}