Journal of atherosclerosis and thrombosis最新文献

{"title":"Role of T1-weighted MRI in Identifying Coronary Intraplaque Hemorrhage: CATCH the Truly High-Risk Plaque.","authors":"Hidenari Matsumoto","doi":"10.5551/jat.66089","DOIUrl":"https://doi.org/10.5551/jat.66089","url":null,"abstract":"<p><p>Intraplaque hemorrhage (IPH) is a key feature of plaque vulnerability that contributes to atherothrombotic events. Non-invasive coronary plaque imaging has been challenging because of the small size of the coronary arteries and motion caused by cardiac contraction and respiration. Recent advances in magnetic resonance imaging (MRI) have enabled the non-invasive detection of coronary IPH. Compared with coronary computed tomography angiography and intravascular imaging modalities, MRI offers unique noninvasive tissue characterization based on intrinsic signal properties. Histopathological and intravascular imaging investigations have indicated that erythrocyte-derived materials, rather than lipid components, constitute the predominant substrate of coronary high-intensity plaques, reflecting recent IPH. This review summarizes the pathophysiological basis, imaging characteristics, and clinical implications of MRI-detected coronary IPH, in the context of other imaging modalities.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching from Conventional Fibrates to Pemafibrate Improves Lipid Profiles, Liver Enzymes, Renal Function, and Fibrosis Markers in Dyslipidemic Patients with MASLD: A Multicenter Real-World Study.","authors":"Takao Sato, Toshihiro Miyamoto, Ryoma Fukuoka, Kazumasa Sugimoto, Yoko Tanimoto, Takashi Nakayama, Kojiro Tanimoto, Koichiro Sugimura, Yoshihide Fujimoto, Takahiko Kiyooka, Akio Kawamura","doi":"10.5551/jat.66030","DOIUrl":"https://doi.org/10.5551/jat.66030","url":null,"abstract":"<p><strong>Aims: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent worldwide. Conventional fibrates effectively lower triglycerides but may elevate liver enzymes and creatinine, limiting long-term use. Pemafibrate, a selective PPARα modulator (SPPARMα), offers potent triglyceride reduction with favorable hepatic and renal safety. This study evaluated the effects of switching from conventional fibrates to pemafibrate on lipid profiles, liver enzyme, fibrosis indices(Fibrosis-4 index) with particular emphasis on renal safety in clinical practice.</p><p><strong>Methods: </strong>We retrospectively analyzed 144 patients with dyslipidemia, including those with MASLD or chronic kidney disease, who were switched from bezafibrate 200mg (N = 24) or 400mg (N = 30), or fenofibrate 80mg (N = 51) or 160mg (N = 39), to pemafibrate (0.2mg/day). Laboratory parameters were assessed at baseline and 6 months post-switch.</p><p><strong>Results: </strong>Triglycerides decreased significantly, particularly in the bezafibrate 200 mg and fenofibrate 80 mg groups, while other lipid profiles remained stable. Serum alanine aminotransferase decreased significantly with bezafibrate 200mg (29±27 to 17±13U/L, p＜0.05) and fenofibrate 80mg (26±18 to 20±10 U/L, p＜0.05), whereas treatment with bezafibrate (400mg) and fenofibrate (160mg) showed a trend toward reduction. The glutamyl transferase showed a similar trend. The Fibrosis-4 index showed reductions across all groups, reaching statistical significance in bezafibrate200mg (1.51±0.63→1.36±0.47, p = 0.02) and fenofibrate 80mg (1.17±0.37→1.07±0.33, p = 0.001). Renal function remained stable across all groups, with no clinically significant deterioration in estimated glomerular filtration rate, supporting the renal safety of pemafibrate.</p><p><strong>Conclusion: </strong>Switching from conventional fibrates to pemafibrate improved triglyceride levels, liver enzymes, and fibrosis indices in patients with MASLD, while maintaining a favorable renal safety profile.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Conventional Imaging: From Time-Based to Data-Driven Decision-Making in Acute Ischemic Stroke.","authors":"Ichiro Deguchi, Junya Aoki","doi":"10.5551/jat.RV22050","DOIUrl":"https://doi.org/10.5551/jat.RV22050","url":null,"abstract":"<p><p>Reperfusion therapy has profoundly transformed acute ischemic stroke (AIS) care. Initially, treatment decisions relied primarily on time from symptom onset. However, growing evidence has shown that the extent of irreversibly injured tissue and the presence of salvageable brain tissue determine the efficacy and safety of reperfusion therapy. This caused a paradigm shift from time-based selection toward tissue-based assessment, placing neuroimaging at the center of clinical decision-making. This narrative review traces the evolution of imaging-based stroke assessment in the reperfusion era. We review the development and clinical impact of the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and diffusion-weighted imaging (DWI)-ASPECTS, which translated the pathophysiological concept of the ischemic core into a practical, reproducible, routine clinical tool. We discuss the emergence of imaging and clinical mismatch concepts, including perfusion-based ischemic core-penumbra mismatch, as well as clinical-diffusion, MRA-diffusion, and DWI-FLAIR mismatches, which address the limitations of strict time-based criteria and expand treatment opportunities, particularly in patients with unknown onset time. Finally, we examine the growing role of artificial intelligence (AI)-driven automated imaging platforms in acute stroke care, enabling rapid, standardized, and quantitative assessment of ischemic core, penumbra, and vascular pathology. These tools support clinical decision-making under severe time constraints and reduce inter-reader and inter-institutional variability. This iterative process of trial and refinement has shaped the current framework of tissue-based, data-driven stroke care. We discuss how integrating established imaging concepts with emerging AI technologies may further advance precision reperfusion therapy and improve equity and outcomes in AIS treatment.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum Soluble T-cadherin Levels with Metabolic Syndrome in Japanese Participants Undergoing Health Checkups.","authors":"Ryohei Mineo, Shiro Fukuda, Masahito Iioka, Hitoshi Nishizawa, Keitaro Kawada, Yuta Kondo, Yoshinari Obata, Hirofumi Nagao, Yuya Fujishima, Takashi Fujimoto, Koji Yamamoto, Yuji Matsuzawa, Iichiro Shimomura","doi":"10.5551/jat.65980","DOIUrl":"10.5551/jat.65980","url":null,"abstract":"<p><strong>Aims: </strong>Visceral fat accumulation is the central feature of metabolic syndrome and subsequent atherosclerotic cardiovascular disease. Soluble T-cadherin (sT-cad) has been identified in circulation, but its clinical significance in the general population remains unclear. We investigated the associations of circulating sT-cad levels with metabolic syndrome and its components in a population undergoing health checkups.</p><p><strong>Methods: </strong>A total of 1321 Japanese participants (825 males and 496 females) undergoing health checkups were enrolled. Serum levels of sT-cad (130-kDa, 100-kDa, and 30-kDa), adiponectin (APN), and other clinical parameters were measured. Associations between sT-cad and metabolic risk factors were analyzed.</p><p><strong>Results: </strong>Among the three sT-cad isoforms, serum 130-kDa sT-cad levels were significantly negatively correlated with waist circumference, blood pressure, Homeostatic Model Assessment for Insulin Resistance (HOMA-R), triglycerides, Alanine aminotransferase (ALT), uric acid, and high-sensitivity C-reactive protein (hsCRP), and positively correlated with high-density lipoprotein (HDL) cholesterol and APN. In multivariate analysis, high TG levels and/or HDL-C levels and hsCRP were independent negative determinants of 130-kDa sT-cad levels in both sexes. Furthermore, 130-kDa sT-cad levels decreased progressively with an increasing number of metabolic risk factors (P for trend ＜0.001).</p><p><strong>Conclusion: </strong>Low serum 130-kDa sT-cad levels are associated with the presence and accumulation of metabolic syndrome-related abnormalities in a Japanese population undergoing health checkups. Inflammation and lipid abnormalities of metabolic syndrome (high TG and/or low HDL-C) may influence the serum 130-kDa sT-cad levels.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"402-416"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Safety and Efficacy of Bempedoic Acid in Japanese Patients with Hypercholesterolemia: the CLEAR-J LONG.","authors":"Daisaku Masuda, Kouji Kajinami, Nobutaka Sakayoshi, Daisuke Yokota, Masakazu Nagamine, Yuki Morikawa-Isogai, Shizuya Yamashita","doi":"10.5551/jat.65947","DOIUrl":"10.5551/jat.65947","url":null,"abstract":"<p><strong>Aims: </strong>Bempedoic acid is an ATP citrate lyase (ACLY) inhibitor acting in the cholesterol biosynthesis pathway. This study evaluated long-term safety and efficacy of bempedoic acid 180 mg/day for 52 weeks in Japanese patients with hypercholesterolemia.</p><p><strong>Methods: </strong>A multicenter, open-label, single-arm Phase 3 long-term study was conducted at 26 hospitals and clinics across Japan in patients aged 18 to 85 years. Newly enrolled patients had previously failed to achieve their lipid management targets because of inadequate response to statins or statin intolerance; rollover patients had completed the 12-week treatment period of a domestic Phase 3 confirmatory study (the CLEAR-J trial) and had not met the discontinuation criteria at Week 12.</p><p><strong>Results: </strong>Bempedoic acid was administered to 130 patients. Treatment-emergent adverse events (TEAEs) occurred in 83.8%, treatment-related TEAEs in 14.6%, serious TEAEs in 6.2%, and AEs leading to discontinuation in 4.6%. None were severe. Between baseline and Week 52, low-density lipoprotein-cholesterol (LDL-C) decreased by 21.6% (overall population) and 25.3% (newly enrolled group), as observed in both statin response subgroups. LDL-C target levels based on risk category were achieved by 65.6% at Week 52 (overall population). Long-term efficacy was also demonstrated for non-high-density lipoprotein cholesterol, total cholesterol, apolipoprotein B, and high-sensitivity C-reactive protein.</p><p><strong>Conclusions: </strong>Bempedoic acid 180 mg/day for 52 weeks was well tolerated in patients with hypercholesterolemia, with no major safety concerns. Serious AEs were infrequent, and no new safety signals specific to the Japanese population were observed. More than 60% of patients achieved and sustained their LDL-C target levels.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"449-469"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Dense Low-density Lipoprotein Cholesterol as a Prognostic Risk Factor in Premature Acute Coronary Syndrome with Multivessel Disease: A Retrospective Cohort Study.","authors":"Munawaer Keremu, Ze-Xin Zhou, Xiao-Lei Li, Xiao-Mei Li, Fen Liu, Adila Wulamu, Shu-Ying Ding, Xia Li, Yu-Nan Wang, Dilare Adi, Yi-Tong Ma","doi":"10.5551/jat.65810","DOIUrl":"10.5551/jat.65810","url":null,"abstract":"<p><strong>Aim: </strong>Small dense low-density lipoprotein cholesterol (sdLDL-C) is recognized as an atherogenic risk factor. This study investigated the prognostic significance of sdLDL-C levels in patients with premature acute coronary syndrome (PACS) and multivessel disease (MVD).</p><p><strong>Methods: </strong>This retrospective study enrolled 847 hospitalized patients diagnosed with PACS and MVD between May 2022 and November 2023. Patients were stratified based on clinical outcomes and tertiles of sdLDL-C levels. Multivariate Cox proportional hazard models were applied to determine whether or not sdLDL-C was a prognostic risk factor for major adverse cardiovascular events (MACEs). Cumulative event curves were estimated using the Kaplan-Meier method. The predictive efficacy of sdLDL-C for MACEs was assessed through a time-dependent receiver operating characteristic (ROC) analysis. In addition, a restricted cubic spline (RCS) analysis was conducted to explore the relationship between sdLDL-C levels and the risk of MACEs.</p><p><strong>Results: </strong>During a median follow-up of 12 months (interquartile range: 9-15 months), 124 MACEs (14.64%) were observed. The sdLDL-C levels in the MACEs group were significantly higher compared to the non-MACEs group (P＜0.001). A multivariate Cox hazards regression analysis revealed that the risk of MACEs in the highest sdLDL-C tertile group was 2.38 times greater than in the lowest tertile group (hazard ratio [HR]: 2.38, 95% confidence interval [CI]: 1.42-4.00; P = 0.001). Furthermore, each 1-mg/dL increase in sdLDL-C levels corresponded to a 12.2% increase in the risk of MACEs (HR: 1.12, 95% CI: 1.08-1.16; P＜0.001). A Kaplan-Meier survival analysis identified significant differences in event-free survival among sdLDL-C tertiles (log-rank test, P＜0.001). The time-dependent ROC analysis demonstrated a progressive increase in the area under the curve during the follow-up period, particularly within the first 12 months. The RCS analysis revealed a nonlinear dose-response relationship between higher sdLDL-C levels and increased cumulative risk of MACEs (P_nonlinear = 0.001).</p><p><strong>Conclusion: </strong>sdLDL-C is a predominant predictor of a poor prognosis in patients with PACS and MVD, underscoring its clinical relevance for risk stratification and the early identification of high-risk individuals who may benefit from targeted intervention.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"470-487"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting Soluble T-Cadherin Through the Lens of Cardiovascular-Kidney-Metabolic Health.","authors":"Yasuhiro Endo, Kei Sasaki, Katsunori Ikewaki","doi":"10.5551/jat.ED299","DOIUrl":"10.5551/jat.ED299","url":null,"abstract":"","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"380-381"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher Small Dense LDL Cholesterol to LDL Cholesterol Ratio is Associated with Glomerular Hyperfiltration in Adults without Diabetes.","authors":"Nobuhisa Morimoto, Yasushi Yamamoto, Ryoko Toragai, Toshio Kuroshima, Yoshiyuki Watanabe, Yasuki Ito, Masumi Ai","doi":"10.5551/jat.65852","DOIUrl":"10.5551/jat.65852","url":null,"abstract":"<p><strong>Aims: </strong>While glomerular hyperfiltration (GHF) emerged as a risk factor for cardiovascular disease (CVD), little is known about the association between GHF and blood lipid profile. We aimed to examine the association between GHF and blood lipid parameters in adults with few comorbidities.</p><p><strong>Methods: </strong>A cross-sectional study was performed on adults undergoing health screening in Osaka, Japan. Adults with a history of heart disease or stroke, those with diabetes mellitus, chronic kidney disease (estimated glomerular filtration rate (eGFR) ＜60 mL/min/1.73m²), or those using lipid-lowering medication were excluded. The outcome was GHF, defined as ＞95^th percentile of eGFR after stratification by age and sex. The exposure was blood lipid parameters, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), non-HDL-C, TG/HDL-C ratio, small dense LDL-C (sdLDL-C), and sdLDL-C/LDL-C ratio. Associations between blood lipid parameters and GHF were examined by multiple logistic regression under a Bayesian framework, adjusted for established risk factors of GHF, including body mass index, blood pressure, and lifestyle factors.</p><p><strong>Results: </strong>Of 17,288 eligible individuals (mean age 50.1±9.9 years; 45.5% women), 853 individuals (4.9%) had GHF. Multiple logistic regression analyses demonstrated an association between a higher sdLDL-C/LDL-C ratio and GHF (odds ratio (OR) = 1.51, 95% credible interval (CrI) 1.21-1.88). LDL-C showed an inverse association with GHF (OR = 0.94, 95% CrI 0.92-0.97).</p><p><strong>Conclusion: </strong>Our findings demonstrated an independent association between a higher sdLDL-C/LDL-C ratio and GHF. The role of an sdLDL-C/LDL-C ratio in GHF development and CVD risk merits further investigation.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"503-519"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mysterious Question on Discordance between Achilles Tendon Thickness Assessed by Ultrasound and X-ray Has been Solved.","authors":"Hayato Tada","doi":"10.5551/jat.ED300","DOIUrl":"10.5551/jat.ED300","url":null,"abstract":"","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":"33 4","pages":"382-383"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlamydia pneumoniae Seropositivity is Associated with Cardiovascular Events in the General Population: The Nagahama Study.","authors":"Aya Ogawa, Aya Shoji-Asahina, Takahisa Kawaguchi, Takeo Nakayama, Fumihiko Matsuda, Yasuharu Tabara","doi":"10.5551/jat.65868","DOIUrl":"10.5551/jat.65868","url":null,"abstract":"<p><strong>Aims: </strong>Persistent Chlamydia pneumoniae (C. pneumoniae) infection has been suggested to be a risk factor for cardiovascular events; however, only findings from studies on small populations are available so far. This study investigated this hypothesis in a large general population through a longitudinal analysis.</p><p><strong>Methods: </strong>We included 9,064 community residents who participated in the Nagahama study (mean age: 52.8 years). C. pneumoniae infection (seropositivity) was determined by serum levels of immunoglobulin A and immunoglobulin G assessed by enzyme-linked immunoassay. The incidence rates of cardiovascular diseases (CVDs), including stroke and coronary artery diseases, were determined by reviewing participants' hospital records and death certificates. Basic clinical parameters were obtained using the baseline survey of the Nagahama study.</p><p><strong>Results: </strong>During a mean follow-up duration of 4,390 days, we observed 323 cases of CVDs. The incidence rates of CVDs were 45.0 and 24.5 per 10,000 person-years in the seropositive and seronegative groups, respectively (log-rank test: p＜0.001). The results of the Cox proportional hazard model analysis indicated that C. pneumoniae seropositivity was remarkably associated with CVDs (1.30, 95% confidence interval: 1.04-1.64) after adjusting for established risk factors, including arterial stiffness (p = 0.023). The hazard ratio was higher in the subpopulation aged ≤ 55 years (2.62, 95% confidence interval: 1.45-4.75, p = 0.001) and reached 3.66 (95% confidence interval: 1.39-9.65, p = 0.009) in the subpopulation aged ≤ 45 years.</p><p><strong>Conclusion: </strong>C. pneumoniae seropositivity was significantly associated with CVDs incidence, especially in adolescents and middle-aged individuals.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"428-440"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}