Journal of atherosclerosis and thrombosis最新文献

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The longitudinal Relationship between Educational Level and Arterial Stiffness: The Toon Health Study. 教育水平与动脉僵硬度的纵向关系:卡通健康研究。
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-28 DOI: 10.5551/jat.65089
Moemi Miura, Ai Ikeda, Kiyohide Tomooka, Koutatsu Maruyama, Ryoichi Kawamura, Yasunori Takata, Haruhiko Osawa, Isao Saito, Takeshi Tanigawa
{"title":"The longitudinal Relationship between Educational Level and Arterial Stiffness: The Toon Health Study.","authors":"Moemi Miura, Ai Ikeda, Kiyohide Tomooka, Koutatsu Maruyama, Ryoichi Kawamura, Yasunori Takata, Haruhiko Osawa, Isao Saito, Takeshi Tanigawa","doi":"10.5551/jat.65089","DOIUrl":"https://doi.org/10.5551/jat.65089","url":null,"abstract":"<p><strong>Aim: </strong>Previous studies have shown that higher educational levels are associated with slower progression of arterial stiffness; however, evidence from Asian countries is lacking. We aimed to examine the association between educational level and arterial stiffness measured using the cardio-ankle vascular index (CAVI) over time in a sample of Japanese men and women.</p><p><strong>Methods: </strong>A total of 1381 participants (453 men and 928 women) were included in the present study. Arterial stiffness was measured using the CAVI at baseline (2009-2012) and 5 years later (2014-2018). The educational level was divided into two groups (junior or senior high school vs. junior college, professional school, college, or higher) based on a self-administered questionnaire. A mixed-effects model was used to analyze the association between education and the CAVI at baseline and its change over 5 years. The participants were stratified by sex and age (<65 vs. ≥ 65 years).</p><p><strong>Results: </strong>The CAVI at baseline did not differ significantly according to education in any of the four subgroups accorded to age and sex. However, among women of ≥ 65 years of age, the change in the CAVI over 5 years was significantly smaller in the higher education group (p=0.04). No such association was found in women of <65 years of age or men.</p><p><strong>Conclusions: </strong>Education is a factor that affects arterial stiffness in women of ≥ 65 years of age. These results suggest that educational level affects arterial stiffness, depending on sex and age.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Genetic Testing and Sex Differences among Patients with Familial Hypercholesterolemia: The Hokuriku-plus Familial Hypercholesterolemia Registry Study. 家族性高胆固醇血症患者基因检测和性别差异的影响:Hokuriku-plus家族性高胆固醇血症登记研究
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-28 DOI: 10.5551/jat.65359
Hayato Tada, Hirofumi Okada, Shohei Yoshida, Masaya Shimojima, Akihiro Nomura, Toyonobu Tsuda, Mika Mori, Shin-Ichiro Takashima, Takeshi Kato, Soichiro Usui, Kenji Sakata, Kenshi Hayashi, Noboru Fujino, Akihiro Inazu, Katsuhiko Nagase, Eishiro Mizukoshi, Masa-Aki Kawashiri, Masayuki Takamura
{"title":"Impact of Genetic Testing and Sex Differences among Patients with Familial Hypercholesterolemia: The Hokuriku-plus Familial Hypercholesterolemia Registry Study.","authors":"Hayato Tada, Hirofumi Okada, Shohei Yoshida, Masaya Shimojima, Akihiro Nomura, Toyonobu Tsuda, Mika Mori, Shin-Ichiro Takashima, Takeshi Kato, Soichiro Usui, Kenji Sakata, Kenshi Hayashi, Noboru Fujino, Akihiro Inazu, Katsuhiko Nagase, Eishiro Mizukoshi, Masa-Aki Kawashiri, Masayuki Takamura","doi":"10.5551/jat.65359","DOIUrl":"https://doi.org/10.5551/jat.65359","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to clarify the degree and factors associated with low-density lipoprotein (LDL)-cholesterol treatment target attainment among patients with heterozygous familial hypercholesterolemia (HeFH) using the Hokuriku-plus FH registry.</p><p><strong>Methods: </strong>The Hokuriku-plus FH registry (UMIN000038210) was a prospective, observational, multicenter cohort study that enrolled consecutive patients with FH who fulfilled the clinical criteria for FH in Japan from 37 participating hospitals, mostly in the Hokuriku region, from April 2020 to March 2024. This registry collects data on clinical parameters, including lipid levels, physical findings, genetic background, and clinical events. In total, 431 patients were enrolled, and the median followup period was 3.1 years. We assessed the degree and factors associated with LDL-cholesterol treatment target attainment among patients with HeFH using the Hokuriku-plus FH registry.</p><p><strong>Results: </strong>Among the 431 patients, sufficient data were collected from 386 patients. Logistic regression analysis revealed that male sex (odds ratio [OR] = 2.16, 95% confidence interval [CI]: 1.14-3.18, p<0.001) and genetic testing (OR = 1.68, 95% CI: 1.10-2.26, p<0.001) were significantly associated with LDL-cholesterol treatment target attainment. In fact, female patients were less likely to attain LDL-cholesterol treatment target than male patients (24.0% vs. 38.1%, p<0.001), and patients who did not undergo genetic testing were less likely to attain LDL-cholesterol treatment target than those who underwent genetic testing (24.5% vs. 37.1%, p<0.001).</p><p><strong>Conclusion: </strong>Sex bias and masked genetic status are significant barriers to the clinical management of patients with HeFH.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Ability of Risk Models in the Field of Ischemic Stroke for Predicting Atherosclerotic Outcomes in Patients with Acute Myocardial Infarction. 缺血性卒中风险模型在预测急性心肌梗死患者动脉粥样硬化预后方面的诊断能力
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-26 DOI: 10.5551/jat.65162
Hiroki Goto, Yuichi Saito, Hiroaki Yaginuma, Kazunari Asada, Takanori Sato, Osamu Hashimoto, Hideki Kitahara, Yoshio Kobayashi
{"title":"Diagnostic Ability of Risk Models in the Field of Ischemic Stroke for Predicting Atherosclerotic Outcomes in Patients with Acute Myocardial Infarction.","authors":"Hiroki Goto, Yuichi Saito, Hiroaki Yaginuma, Kazunari Asada, Takanori Sato, Osamu Hashimoto, Hideki Kitahara, Yoshio Kobayashi","doi":"10.5551/jat.65162","DOIUrl":"https://doi.org/10.5551/jat.65162","url":null,"abstract":"<p><strong>Aims: </strong>Several risk-scoring models, including the Fukuoka Stroke Risk Score, Essen Stroke Risk Score, and Stroke Prognosis Instrument II, have been developed to predict recurrent cerebrovascular events in patients with ischemic stroke. As myocardial infarction (MI) and ischemic stroke are both atherosclerotic diseases, these scoring models in the field of cerebrovascular disease may be applicable and useful for risk stratification in patients with acute MI. We therefore evaluated the diagnostic ability and clinical applicability of these stroke risk scores in predicting atherosclerotic events after acute MI.</p><p><strong>Methods: </strong>This multicenter retrospective study included 2016 patients with acute MI who underwent percutaneous coronary intervention and survived to discharge. The three risk-scoring models were calculated, and their diagnostic ability for major adverse cardiovascular events (MACE) after discharge, a composite of cardiovascular death, recurrent MI, and ischemic stroke, was evaluated.</p><p><strong>Results: </strong>During the median follow-up of 523 days, 218 (10.8%) patients experienced MACE after discharge. High values for Fukuoka Stroke Risk Score, Essen Stroke Risk Score, and Stroke Prognosis Instrument II were progressively associated with an increased risk of MACE after discharge. Overall, the diagnostic abilities of the three risk scores were similar.</p><p><strong>Conclusions: </strong>Risk prediction models in the field of ischemic stroke, including the Fukuoka Stroke Risk Score, Essen Stroke Risk Score, and Stroke Prognosis Instrument II, were useful in stratifying MACE risk in patients with acute MI. Risk-scoring models for atherosclerotic cardiovascular disease may be applicable to patient populations with other cardiovascular diseases in different arterial territories.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atherogenic Dyslipidemia Is Critically Related to Aortic Complicated Lesions in Cryptogenic Stroke. 动脉粥样硬化性血脂异常与隐源性卒中的主动脉并发症密切相关。
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-26 DOI: 10.5551/jat.65289
Muneaki Kikuno, Yuji Ueno, Yohei Tateishi, Ayako Kuriki, Ryosuke Doijiri, Takahiro Shimizu, Hidehiro Takekawa, Kodai Kanemaru, Yoshiaki Shimada, Eriko Yamaguchi, Masatoshi Koga, Yuki Kamiya, Masafumi Ihara, Akira Tsujino, Koichi Hirata, Yasuhiro Hasegawa, Hitoshi Aizawa, Hiroo Terashi, Nobutaka Hattori, Takao Urabe
{"title":"Atherogenic Dyslipidemia Is Critically Related to Aortic Complicated Lesions in Cryptogenic Stroke.","authors":"Muneaki Kikuno, Yuji Ueno, Yohei Tateishi, Ayako Kuriki, Ryosuke Doijiri, Takahiro Shimizu, Hidehiro Takekawa, Kodai Kanemaru, Yoshiaki Shimada, Eriko Yamaguchi, Masatoshi Koga, Yuki Kamiya, Masafumi Ihara, Akira Tsujino, Koichi Hirata, Yasuhiro Hasegawa, Hitoshi Aizawa, Hiroo Terashi, Nobutaka Hattori, Takao Urabe","doi":"10.5551/jat.65289","DOIUrl":"https://doi.org/10.5551/jat.65289","url":null,"abstract":"<p><strong>Aims: </strong>Atherogenic dyslipidemia (AD) is regarded as a residual risk of cardiovascular diseases characterized by low high-density lipoprotein cholesterol (HDL-C) and high triglyceride (TG) levels and related to the intracranial stenosis of atheromatous thrombotic brain infarction (ATBI). Further, atherosclerosis is possibly related to another stroke subtype, including cryptogenic stroke (CS). In particular, an aortic complicated lesion (ACL) is a notable embolic source of CS, since recurrence of aortogenic brain embolism is not rare. This study aimed to clarify the underlying association between AD and CS.</p><p><strong>Methods: </strong>CHALLENGE ESUS/CS (Mechanisms of Embolic Stroke Clarified by Transesophageal Echocardiography for ESUS/CS) had extensive data from CS patients who underwent transesophageal echocardiography (TEE). AD was defined as HDL-C ≤ 40 mg/dl and TG ≥ 150 mg/dl. Based on these criteria, patients were divided into an AD group and a non-AD group to compare the clinical features.</p><p><strong>Results: </strong>Of 664 CS patients (446 men, 68.7±12.8 years), 68 (10.2%) met the criteria of AD (AD group), and 596 (89.8%) were in the non-AD group. On multiple logistic regression analysis, body mass index (unit OR 1.11, 95%CI 1.04-1.19, p=0.002), diabetes mellitus (OR 2.23, 95%CI 1.28-3.87, p=0.004), ACL in the arch (OR 1.89, 95%CI 1.09-3.31, p=0.025), and deterioration during hospitalization (OR 3.96, 95%CI 1.32-10.68, p=0.009) were independently associated with AD.</p><p><strong>Conclusion: </strong>AD was not rare in the present CS population. Moreover, AD was crucially related to ACL in CS. Therefore, intensive and pleiotropic lipid-modifying therapy would be efficacious for further treatment of aortogenic brain embolism.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T50 Calciprotein Crystallization and the Decreased Role of Fetuin-A in Type 2 Diabetes. T50钙蛋白结晶和胎儿素a在2型糖尿病中的作用降低。
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-25 DOI: 10.5551/jat.65351
Yu Nagakura, Tetsuo Shoji, Shinya Fukumoto, Hideki Uedono, Shinya Nakatani, Katsuhito Mori, Yuki Nagata, Yasuo Imanishi, Tomoaki Morioka, Toshio Watanabe, Masanori Emoto
{"title":"T50 Calciprotein Crystallization and the Decreased Role of Fetuin-A in Type 2 Diabetes.","authors":"Yu Nagakura, Tetsuo Shoji, Shinya Fukumoto, Hideki Uedono, Shinya Nakatani, Katsuhito Mori, Yuki Nagata, Yasuo Imanishi, Tomoaki Morioka, Toshio Watanabe, Masanori Emoto","doi":"10.5551/jat.65351","DOIUrl":"https://doi.org/10.5551/jat.65351","url":null,"abstract":"<p><strong>Aim: </strong>Patients with type 2 diabetes mellitus (T2D) are prone to develop vascular calcification. Fetuin-A protects against vascular calcification but it increases insulin resistance. T50 calciprotein crystallization (also called serum calcification propensity) is a novel marker of calcification stress. This study examined whether T2D affects T50 and the potential role of fetuin-A in the relationship between T2D and T50.</p><p><strong>Methods: </strong>This cross-sectional study included 101 individuals with T2D and 101 individuals without diabetes (controls). T50 and fetuin-A levels were measured using the established nephelometric method and an enzyme-linked immunosorbent assay, respectively.</p><p><strong>Results: </strong>Although fetuin-A levels were higher in the T2D group, T50 was not significantly different between the T2D and control groups. In multivariable-adjusted analyses of the total population, T50 was not independently associated with the presence of T2D, fasting plasma glucose, or HbA1c, whereas T50 was significantly associated with fetuin-A, phosphate, and calcium levels. The association between T50 and fetuin-A was modified by the presence of T2D. A subgroup analysis revealed that the positive association between T50 and fetuin-A was significant but smaller in the T2D group, and that the associations of T50 with serum phosphate and calcium were more evident in the T2D group. Additional analyses showed that T50/fetuin-A ratio was lower in the T2D group and that T50/fetuin-A ratio was inversely correlated with fasting glucose and HbA1c levels.</p><p><strong>Conclusions: </strong>T2D itself was not significantly associated with T50 but T2D modified the association between T50 and fetuin-A in favor of developing vascular calcification in T2D.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Factors Associated with 2-year Mortality in Patients with Intermittent Claudication Treated with Endovascular Therapy for Femoropopliteal Lesions: Results from the Multicenter PROCYON Study. 经股腘动脉内治疗的间歇性跛行患者2年死亡率相关的预后因素:来自多中心PROCYON研究的结果
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-25 DOI: 10.5551/jat.65379
Tatsuro Takei, Takahiro Tokuda, Naoki Yoshioka, Kenji Ogata, Akiko Tanaka, Shunsuke Kojima, Kohei Yamaguchi, Takashi Yanagiuchi, Tatsuya Nakama
{"title":"Prognostic Factors Associated with 2-year Mortality in Patients with Intermittent Claudication Treated with Endovascular Therapy for Femoropopliteal Lesions: Results from the Multicenter PROCYON Study.","authors":"Tatsuro Takei, Takahiro Tokuda, Naoki Yoshioka, Kenji Ogata, Akiko Tanaka, Shunsuke Kojima, Kohei Yamaguchi, Takashi Yanagiuchi, Tatsuya Nakama","doi":"10.5551/jat.65379","DOIUrl":"https://doi.org/10.5551/jat.65379","url":null,"abstract":"<p><strong>Aim: </strong>Few studies have evaluated the midterm prognosis of patients with intermittent claudication who underwent endovascular therapy (EVT) for femoropopliteal lesions. Therefore, we aimed to assess 2-year mortality and prognostic factors in these patients.</p><p><strong>Methods: </strong>We retrospectively analyzed 947 patients who underwent EVT for intermittent claudication between January 2018 and December 2021 at eight Japanese cardiovascular centers. Kaplan-Meier survival analysis was performed for mortality, and prognostic factors were analyzed using the Cox proportional hazards regression model. Patient backgrounds and medications were included in the investigation of prognostic factors.</p><p><strong>Results: </strong>Notably, 79 deaths occurred during the mean follow-up period of 20.9±6.2 months. The 2-year mortality rate was 9.1%. In multivariate analysis, body mass index (BMI) <18.5 kg/m<sup>2</sup> (p<0.001), coronary artery disease (CAD) (p<0.001), dialysis (p<0.001), and ankle-brachial pressure index (ABI) <0.6 (p=0.012) were risk factors. Statins and cilostazol were protective factors (p=0.014 and p=0.036, respectively). When the study population was stratified based on the number of these risk factors, the mortality rate was highest (32.5% at 2 years) in patients with at least three risk factors. However, when stratified according to protective factors, the mortality rate was lowest in patients with two protective factors (2.1% at 2 years).</p><p><strong>Conclusions: </strong>Dialysis, low BMI, CAD, and low ABI were risk factors for a worse 2-year prognosis in patients with intermittent claudication who underwent EVT for femoropopliteal lesions. Statins and cilostazol may improve the 2-year prognosis of patients with lower extremity artery disease.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Pemafibrate on LDL-C and Related Lipid Markers in Patients with MASLD: A Sub-Analysis of the PEMA-FL Study. pemafbrate对MASLD患者LDL-C及相关脂质标志物的影响:pama - fl研究的亚分析
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-18 DOI: 10.5551/jat.65395
Ryohei Tanigawa, Atsushi Nakajima, Yuichiro Eguchi, Hirokazu Takahashi, Rohit Loomba, Hideki Suganami, Masaya Tanahashi, Ayumi Saito, Yuki Iida, Shizuya Yamashita
{"title":"Effects of Pemafibrate on LDL-C and Related Lipid Markers in Patients with MASLD: A Sub-Analysis of the PEMA-FL Study.","authors":"Ryohei Tanigawa, Atsushi Nakajima, Yuichiro Eguchi, Hirokazu Takahashi, Rohit Loomba, Hideki Suganami, Masaya Tanahashi, Ayumi Saito, Yuki Iida, Shizuya Yamashita","doi":"10.5551/jat.65395","DOIUrl":"https://doi.org/10.5551/jat.65395","url":null,"abstract":"<p><strong>Aim: </strong>In the PEMA-FL study in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), pemafibrate was shown to significantly decrease low-density lipoprotein cholesterol (LDL-C) levels. We aimed to investigate the mechanisms of pemafibrate-induced LDL-C reduction in patients with MASLD by conducting an additional sub-analysis of the PEMA-FL study.</p><p><strong>Methods: </strong>The PEMA-FL study randomized 118 patients with MASLD to receive pemafibrate or placebo for 72 weeks. This sub-analysis examined the percentage change in LDL-C and related lipid markers by tertile of baseline LDL-C levels and the correlation between these changes in the pemafibrate group.</p><p><strong>Results: </strong>Pemafibrate significantly decreased LDL-C levels approximately 25% (p<0.001 at all timepoints) from baseline in the highest tertile of baseline LDL-C levels (≥ 137.5 mg/dL), with similar trends for non-high-density lipoprotein cholesterol (non-HDL-C) and apolipoprotein B (ApoB) levels. Lipoprotein (a) [Lp(a)] levels decreased only in patients with the highest baseline LDL-C levels. Regardless of the baseline LDL-C levels, pemafibrate altered the LDL particle profile (increased LDL particle size and decreased the number); reduced lathosterol, β-sitosterol, and campesterol; and increased angiopoietin-like protein 3 (ANGPTL3). The percentage change in LDL-C positively correlated with that in ApoB, non-HDL-C, Lp(a), lathosterol, β-sitosterol, and campesterol but not HDL-C and ANGPTL3.</p><p><strong>Conclusion: </strong>Pemafibrate reduced LDL-C, ApoB, and non-HDL-C levels in patients with MASLD, and the effect was greater in those with higher baseline LDL-C levels. Pemafibrate may clinically benefit patients with MASLD by improving LDL-C levels and the LDL particle profile.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triglycerides and the Risk of Atherosclerotic Cardiovascular Events Across Different Risk Categories. 甘油三酯与不同风险类别的动脉粥样硬化性心血管事件风险。
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-13 DOI: 10.5551/jat.65334
Hiroyuki Mizuta, Masanobu Ishii, So Ikebe, Yasuhiro Otsuka, Yoshinori Yamanouchi, Taishi Nakamura, Kenichi Tsujita
{"title":"Triglycerides and the Risk of Atherosclerotic Cardiovascular Events Across Different Risk Categories.","authors":"Hiroyuki Mizuta, Masanobu Ishii, So Ikebe, Yasuhiro Otsuka, Yoshinori Yamanouchi, Taishi Nakamura, Kenichi Tsujita","doi":"10.5551/jat.65334","DOIUrl":"https://doi.org/10.5551/jat.65334","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the association between triglyceride levels and major adverse cardiovascular events (MACE) in primary and secondary prevention cohorts.</p><p><strong>Methods: </strong>This retrospective study was conducted with a nationwide health insurance claims database, which included approximately 3.8 million participants with medical checkups between January 2005 and August 2020 in Japan. The participants were classified into primary prevention (n=3,415,522) and secondary prevention (n=29,806) cohorts based on cardiovascular or cerebrovascular disease history. Each participant was categorized as having very low (triglyceride <50 mg/dL), low normal (50-99), high normal (100-149), or hypertriglyceridemia (≥ 150). The primary prevention cohort was further stratified into low-, intermediate-, and high-risk groups according to atherosclerotic cardiovascular diseases risk. Outcome was MACE, including acute myocardial infarction (AMI), unstable angina, ischemic stroke, and cardiac death.</p><p><strong>Results: </strong>Over a mean follow-up of 3.25 years, 0.3% and 2.6% MACE occurred in primary and secondary prevention, respectively. Hypertriglyceridemia was associated with high risk of MACE in the primary prevention, but not in the secondary prevention. A significant interaction was observed between prevention categories and the association of TG levels with MACE in those with TG <150 mg/dL and ischemic stroke in those with TG ≥ 150 mg/dL. The population-attributable fraction for hypertriglyceridemia in primary prevention was 4.1% for MACE. In primary prevention, lower risks of AMI were observed in the lower TG category compared to the current threshold.</p><p><strong>Conclusions: </strong>This study suggests distinct triglyceride thresholds for MACE risk in primary and secondary prevention cohorts, requiring further prospective validation for clinical implementation.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Plasma Levels of S-adenosylhomocysteine is Related with the Risk of All-cause and Cardiovascular Mortality in Patients with Coronary Artery Disease. 高血浆s -腺苷型同型半胱氨酸水平与冠心病患者全因死亡率和心血管死亡率相关
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-10 DOI: 10.5551/jat.65083
Si Liu, Yongyi Wang, Mengfeng Yang, Xin Dai, Ting Huang, Ruyi Liao, Hengliang Song, Peng Li, Yun Chen, Haiyan Huang, Changhua Zhang, Yunjun Xiao
{"title":"High Plasma Levels of S-adenosylhomocysteine is Related with the Risk of All-cause and Cardiovascular Mortality in Patients with Coronary Artery Disease.","authors":"Si Liu, Yongyi Wang, Mengfeng Yang, Xin Dai, Ting Huang, Ruyi Liao, Hengliang Song, Peng Li, Yun Chen, Haiyan Huang, Changhua Zhang, Yunjun Xiao","doi":"10.5551/jat.65083","DOIUrl":"https://doi.org/10.5551/jat.65083","url":null,"abstract":"<p><strong>Aims: </strong>Plasma S-adenosylhomocysteine (SAH) level is positively associated with cardiovascular risk. However, the relationship between plasma SAH levels and the risk of all-cause and cardiovascular mortality remains unknown. This study aimed to explore the relationship between plasma SAH levels and the risk of all-cause and cardiovascular mortality in patients with coronary artery disease (CAD).</p><p><strong>Methods: </strong>Plasma SAH levels were measured in 1553 patients with CAD. The association between plasma SAH level and the risk of all-cause and cardiovascular mortality was estimated using Cox Proportional hazards regression models.</p><p><strong>Results: </strong>Relative to participants in the lowest quartile of plasma SAH levels, those in the highest quartile of plasma SAH levels had a higher risk of all-cause death (adjusted Hazard Ratio [HR], 2.15; 95% CI, 1.54-3.01; P<0.001) and cardiovascular death (adjusted HR, 2.20; 95% CI, 1.49-3.25; P=0.001) in the age- and sex-adjusted model. The results of the multivariable adjusted analysis were similar (all-cause death [adjusted HR, 1.81; 95% CI, 1.27-2.58; P=0.002] and cardiovascular death [adjusted HR, 1.84; 95% CI, 1.21-2.79; P=0.031]). The age- and sex-adjusted HRs for each 1 SD increase in plasma SAH level were 1.30 (95% CI, 1.22-1.38) for all-cause mortality, and 1.34 (95% CI, 1.25-1.43) for cardiovascular mortality, respectively. A 1 SD increase in the SAH level was associated with a 25% higher risk of total death (adjusted HR, 1.25; 95% CI, 1.17-1.34) and a 29% greater risk of cardiovascular death (adjusted HR, 1.29; 95% CI, 1.20-1.39) in multivariable adjusted analysis.</p><p><strong>Conclusions: </strong>We found that the plasma SAH level is positively correlated with the risk of all-cause and cardiovascular mortality in patients with CAD in both age- and sex-adjusted and multivariable-adjusted models.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Differences in the Relationship between Arterial Stiffness and Incidence of Chronic Kidney Disease. 动脉僵硬度与慢性肾脏疾病发病率关系的性别差异
IF 3 2区 医学
Journal of atherosclerosis and thrombosis Pub Date : 2024-12-06 DOI: 10.5551/jat.65055
Chang Hee Kwon, Jeonggyu Kang, Ki-Chul Sung
{"title":"Sex Differences in the Relationship between Arterial Stiffness and Incidence of Chronic Kidney Disease.","authors":"Chang Hee Kwon, Jeonggyu Kang, Ki-Chul Sung","doi":"10.5551/jat.65055","DOIUrl":"https://doi.org/10.5551/jat.65055","url":null,"abstract":"<p><strong>Aims: </strong>There is a lack of evidence regarding the sex-specific impact of arterial stiffness on the incidence of chronic kidney disease (CKD). This study assessed the relationship between arterial stiffness based on brachial-ankle pulse wave velocity (baPWV) and incident CKD in men and women.</p><p><strong>Methods: </strong>Individuals who participated in health checkups and underwent concomitant baPWV measurement between 2006 and 2019 were included. They were free of CKD at baseline. The participants were categorized into 4 groups based on their baPWV values (cm/s) as follows: <1,200 cm/s for normal, ≥ 1,200 and <1,400 for high normal, ≥ 1,400 and <1,800 for borderline, and ≥ 1,800 cm/s. The primary outcome was CKD development (estimated glomerular filtration rate <60 mL/min/1.73 m<sup>2</sup>).</p><p><strong>Results: </strong>A total of 130,100 participants were enrolled, with a mean age of 40.5±8.2 years old. During the mean of 5.6 years of follow-up, 906 (0.7%) participants developed incident CKD. The cumulative incidence of CKD was 0.3%, 0.5%, 1.4%, and 6.2% in the normal, high normal, borderline, and abnormal groups, respectively. In the multivariable-adjusted model including systolic blood pressure, compared with the normal baPWV group, abnormal baPWV group demonstrated a significantly increased risk of incident CKD in women. However, among men, any other baPWV groups were not associated with a significantly elevated risk of incident CKD.</p><p><strong>Conclusions: </strong>Increased arterial stiffness, as measured by baPWV, was associated with an increased risk of incident CKD, with notable sex-specific differences. These findings underscore the utility of baPWV for identifying CKD risk in women and offer valuable insights into sex-specific differences in arterial stiffness and CKD development.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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