Journal of atherosclerosis and thrombosis最新文献_第10页

Predictive Value of Lipoprotein(a) Combined with the Suita Score for High-Risk Plaque in Japanese Patients. 脂蛋白(a)结合Suita评分对日本患者高危斑块的预测价值

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-05-01 Epub Date: 2025-12-11 DOI: 10.5551/jat.65904

Yudai Niwa, Hiroyuki Naruse, Hideki Kawai, Eirin Sakaguchi, Yuya Ishihara, Hidekazu Hattori, Komei Uehara, Masaki Ito, Shingo Yamada, Akira Yamada, Takashi Muramatsu, Fumihiko Kitagawa, Hiroshi Takahashi, Junnichi Ishii, Masayoshi Sarai, Masanobu Yanase, Yukio Ozaki, Kuniaki Saito, Hideo Izawa

{"title":"Predictive Value of Lipoprotein(a) Combined with the Suita Score for High-Risk Plaque in Japanese Patients.","authors":"Yudai Niwa, Hiroyuki Naruse, Hideki Kawai, Eirin Sakaguchi, Yuya Ishihara, Hidekazu Hattori, Komei Uehara, Masaki Ito, Shingo Yamada, Akira Yamada, Takashi Muramatsu, Fumihiko Kitagawa, Hiroshi Takahashi, Junnichi Ishii, Masayoshi Sarai, Masanobu Yanase, Yukio Ozaki, Kuniaki Saito, Hideo Izawa","doi":"10.5551/jat.65904","DOIUrl":"10.5551/jat.65904","url":null,"abstract":"Aims: The global distribution of lipoprotein(a) [Lp(a)] levels varies due to racial and ethnic differences. However, the clinical relevance of Lp(a) levels in Japanese patients has not been fully explored.Methods: We investigated the association of Lp(a) levels, the Suita score, and the presence of high-risk plaque (HRP) as well as that of ≥ 50% stenosis, quantitative plaque volume, and the value of coronary artery calcium score in coronary computed tomographic angiography (CCTA), among 272 Japanese patients (mean age: 65 years) in whom serum Lp(a) levels were measured due to suspected coronary artery disease. HRP was defined as positive remodeling and/or low attenuation. Plaque volume was quantified as the percent plaque volume.Results: HRP was identified in 33 (12.1%) patients. The prevalence of HRP, ≥ 50% stenosis, and percent plaque volume progressively increased with higher Lp (a) levels and Suita scores. In multivariate analyses, Lp(a) and the Suita score independently predicted HRP when assessed as continuous (p = 0.02, p＜0.001, respectively) or categorical variables (p = 0.005, p = 0.007, respectively). Patients in the highest tertile of Lp(a) and classified as high- or intermediate-risk by the Suita score had the highest HRP risk, whereas those in the lower 2 tertiles and low-risk group had the lowest. Incorporating Lp(a) into the Suita score improved the prediction of HRP beyond the Suita score alone (p = 0.005).Conclusions: The combinatorial value of assessing Lp(a) levels and Suita score may provide useful insight regarding Japanese patients undergoing CCTA for the prediction of HRP.","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"566-577"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Achilles Tendon Thickness with Severity of Coronary Artery Disease in Non -Familial Hypercholesterolemia. 非家族性高胆固醇血症患者跟腱厚度与冠状动脉疾病严重程度的关系

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-05-01 Epub Date: 2025-12-25 DOI: 10.5551/jat.65995

Shimpei Fujioka, Daisuke Shishikura, Kenta Sakaguchi, Hirofumi Kusumoto, Masahito Michikura, Yumiko Kanzaki, Mariko Harada-Shiba, Hideaki Morita

{"title":"Association of Achilles Tendon Thickness with Severity of Coronary Artery Disease in Non -Familial Hypercholesterolemia.","authors":"Shimpei Fujioka, Daisuke Shishikura, Kenta Sakaguchi, Hirofumi Kusumoto, Masahito Michikura, Yumiko Kanzaki, Mariko Harada-Shiba, Hideaki Morita","doi":"10.5551/jat.65995","DOIUrl":"10.5551/jat.65995","url":null,"abstract":"Aim: Achilles tendon xanthomas are a characteristic feature of familial hypercholesterolemia (FH). Achilles tendon thickness (ATT) has been associated with the severity of coronary artery disease (CAD) in FH. However, its relevance in non-FH remains unclear. Therefore, we assessed the relationship between ATT and CAD severity in patients with acute coronary syndrome (ACS) without FH.Methods: A total of 194 patients (mean age: 69.1±11.9 years) with ACS without FH were retrospectively investigated and divided into two groups: single-vessel disease (SVD) or multivessel disease (MVD). ATT was measured using ultrasonography (US-ATT) and radiography (Xp-ATT). The association between ATT and CAD severity was evaluated.Results: Of the total, 107 patients (55.2%) had SVD, and 87 (44.8%) had MVD. Mean US-ATT and Xp-ATT values were 5.0±0.6 mm and 6.4±1.2 mm, respectively. ATT was significantly greater in the MVD group than in the SVD group (US-ATT: 5.2 mm vs. 4.8 mm, p＜0.01; Xp-ATT: 6.6 mm vs. 6.1 mm, p = 0.01) and correlated with the SYNTAX score (US-ATT: r = 0.30, p＜0.01; Xp-ATT: r = 0.19, p = 0.02). Multivariable analysis identified US-ATT as an independent predictor of MVD (odds ratio: 2.71; 95% confidence interval: 1.46-5.01; p＜0.01).Conclusion: In patients with ACS without FH, ATT was significantly associated with CAD severity. This suggests that ATT, particularly US-ATT, may serve as a practical, non-invasive marker for cardiovascular risk stratification.","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"578-588"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inverse Association between T50 Calciprotein Crystallization (Serum Calcification Propensity) and Carotid Artery Intima-Media Thickness in Health Examinees with a Reduced Kidney Function. 肾功能减退健康体检者T50钙蛋白结晶（血清钙化倾向）与颈动脉内膜-中膜厚度的负相关

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-05-01 Epub Date: 2026-01-16 DOI: 10.5551/jat.65964

Yu Nagakura, Tetsuo Shoji, Shinya Fukumoto, Hideki Uedono, Shinya Nakatani, Katsuhito Mori, Yuki Nagata, Yasuo Imanishi, Tomoaki Morioka, Toshio Watanabe, Masanori Emoto

{"title":"Inverse Association between T50 Calciprotein Crystallization (Serum Calcification Propensity) and Carotid Artery Intima-Media Thickness in Health Examinees with a Reduced Kidney Function.","authors":"Yu Nagakura, Tetsuo Shoji, Shinya Fukumoto, Hideki Uedono, Shinya Nakatani, Katsuhito Mori, Yuki Nagata, Yasuo Imanishi, Tomoaki Morioka, Toshio Watanabe, Masanori Emoto","doi":"10.5551/jat.65964","DOIUrl":"10.5551/jat.65964","url":null,"abstract":"Aim: T50 is the time required for primary calciprotein particles (CPPs) to transform into secondary CPPs in vitro, reflecting serum calcification propensity, and used as a biomarker for calcification stress. Since secondary CPPs induce inflammation and oxidative stress, they may promote atherosclerosis. We investigated whether or not T50 was associated with carotid artery intima-media thickness (IMT).Methods: This was a cross-sectional study of 202 health examinees. T50 was measured by the established nephelometric method. Carotid artery IMT was measured by high-resolution ultrasonography. The association between T50 and IMT was evaluated by a multivariable-adjusted linear regression analysis.Results: In a univariate analysis, IMT was not significantly correlated with T50. A multivariable-adjusted linear regression analysis showed that IMT was independently associated with age, sex, diabetes mellitus, dyslipidemia, and fetuin-A but not with T50 in the total subjects. However, when stratified by the estimated glomerular filtration rate (eGFR), T50 was independently and inversely associated with IMT in the subgroup with an eGFR ＜60 mL/min/1.73 m2 (β = -0.418, P = 0.013), whereas it was not in the subgroup with an eGFR ≥ 60 mL/min/1.73 m2.Conclusion: T50 was independently and inversely associated with IMT in health examinees with a reduced kidney function, suggesting a novel link between calcification stress and atherosclerosis, particularly in those with chronic kidney disease.","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"632-642"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TLR4 Inhibition Attenuates Vascular Remodeling in A Mouse Model of Chronic Kidney Disease. TLR4抑制减缓慢性肾脏疾病小鼠模型血管重构

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-05-01 Epub Date: 2026-02-02 DOI: 10.5551/jat.66076

Tomohiro Shirouzu, Jun-Ichiro Koga, Nasanbadrakh Orkhonselenge, Yasufumi Nagata, Tetsu Miyamoto, Masaharu Kataoka

{"title":"TLR4 Inhibition Attenuates Vascular Remodeling in A Mouse Model of Chronic Kidney Disease.","authors":"Tomohiro Shirouzu, Jun-Ichiro Koga, Nasanbadrakh Orkhonselenge, Yasufumi Nagata, Tetsu Miyamoto, Masaharu Kataoka","doi":"10.5551/jat.66076","DOIUrl":"10.5551/jat.66076","url":null,"abstract":"Aim: Chronic kidney disease (CKD) is linked to accelerated vascular remodeling, characterized by medial thickening and fibrosis; however, the molecular mechanisms driving this process remain unclear.Methods: We investigated the role of toll-like receptor 4 (TLR4) in CKD-associated vascular remodeling using a 5/6 nephrectomy mouse model. TLR4 signaling was selectively inhibited by the long-term administration of TAK-242, a small-molecule-specific inhibitor of TLR4.Results: TLR4 blockade decreased aortic medial thickening and perivascular fibrosis independent of blood pressure. Immunostaining revealed that blockade of TLR4 decreased Mac-3-positive macrophage accumulation and Ki-67-positive proliferating cells in the aorta. The mRNA expression of IL-6 was suppressed in aortas treated with TAK-242. Disulfide HMGB1 induced the expression of IL-6 in macrophages. Serum from CKD mice induced the expression of IL-6 in RAW264.7 cells and promoted in vitro vascular smooth muscle cell growth, both of which were attenuated with serum from TAK-242-treated CKD mice.Conclusion: These findings suggest that TLR4-mediated sterile inflammation may contribute to vascular remodeling in CKD and that modulation of TLR4 signaling could be explored as a potential therapeutic strategy to mitigate cardiovascular complications in CKD patients.","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"643-654"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Elevated Serum Apolipoprotein C-III Concentration is Associated with the Risk of Coronary Heart Disease in a Japanese General Population. The Hidaka Cohort Study. 日本普通人群血清载脂蛋白C-III浓度升高与冠心病风险相关Hidaka队列研究。

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-05-01 Epub Date: 2026-02-02 DOI: 10.5551/jat.66073

Yoshio Fujioka, Shin-Ichiro Tanaka, Takeshi Tsujino, Tatsuro Ishida, Ken-Ichi Hirata

{"title":"An Elevated Serum Apolipoprotein C-III Concentration is Associated with the Risk of Coronary Heart Disease in a Japanese General Population. The Hidaka Cohort Study.","authors":"Yoshio Fujioka, Shin-Ichiro Tanaka, Takeshi Tsujino, Tatsuro Ishida, Ken-Ichi Hirata","doi":"10.5551/jat.66073","DOIUrl":"10.5551/jat.66073","url":null,"abstract":"Aim: Apolipoprotein CIII (ApoC-III) is a lipid-associated protein crucial for the lipid metabolism. Recent studies have shown that ApoC-III also plays a role in vascular dysfunction and the development of coronary heart disease (CHD). This study examined the hypothesis that the serum ApoC-III concentration is associated with the future risk of CHD in a general Japanese population.Methods: We prospectively studied 1,676 individuals (1,005 women, 671 men; mean age 57.1 years) in a rural community in Japan. In the 1993 baseline survey, anthropometric examinations, current smoking status, blood pressure, and serum concentrations of lipids and apolipoproteins were assessed. During the follow-up period of 10.9 years (interquartile range 10.8 - 11.1), 48 participants developed CHD, including 18 fatal and non-fatal myocardial infarction patients and 30 sudden death cases.Results: In the age- and sex-adjusted analysis, we did not find any association between the baseline serum ApoC-III concentration and the risk of CHD and sudden death (HR 2.11, CI 0.88 - 5.03, P = 0.094). However, in a multivariable analysis adjusted for age, sex, the presence of hypertension, presence of diabetes mellitus, current smoking status, total cholesterol, high-density lipoprotein cholesterol, and triglycerides, serum ApoC-III concentration was significantly associated with the risk of CHD and sudden death (HR 3.59, CI 1.05 - 12.3, P = 0.041).Conclusion: Serum ApoC-III concentration was independently associated with the risk of CHD and sudden death in a general Japanese population.","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"655-664"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Affecting Body Weight/Waist Circumference Changes after Specific Health Guidance for Obese People with CVD Risk Factors in Japan. 日本伴有心血管疾病危险因素的肥胖人群接受特殊健康指导后体重/腰围变化的影响因素

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-05-01 Epub Date: 2025-12-23 DOI: 10.5551/jat.65943

Nagako Okuda, Koshi Nakamura, Makoto Watanabe, Kei Kamide, Katsushi Yoshita, Sayuki Torii, Katsuyuki Miura, Aya Higashiyama, Kozo Tanno, Yuki Yonekura, Tomomi Nagahata, Toru Kuribayashi, Akira Okayama

{"title":"Factors Affecting Body Weight/Waist Circumference Changes after Specific Health Guidance for Obese People with CVD Risk Factors in Japan.","authors":"Nagako Okuda, Koshi Nakamura, Makoto Watanabe, Kei Kamide, Katsushi Yoshita, Sayuki Torii, Katsuyuki Miura, Aya Higashiyama, Kozo Tanno, Yuki Yonekura, Tomomi Nagahata, Toru Kuribayashi, Akira Okayama","doi":"10.5551/jat.65943","DOIUrl":"10.5551/jat.65943","url":null,"abstract":"Aim: Specific Health Checkups (SHCs) and Specific Health Guidance (SHG) were launched in 2008, but the factors related to their effectiveness have not been clarified. We examined the mean reduction in body weight (BW) and waist circumference (WC) of participants eligible for active support under SHG. Body size was considered, as well as the number of support points given during SHG, which indicates the amount of support they received.Methods: A dataset of participants (aged 40-64) who were eligible for SHG and had SHC results collected between 2011 and 2012 was analyzed (n = 76,565). The mean changes in BW and WC between 2011 and 2012 were compared among participants based on their participation status (did not participate, dropped out, finished) and the number of support points for those who finished. Participants were also stratified by sex and BMI (kg/m2): normal weight, overweight, and obese.Results: The mean BW change (95% CI) for those who did not participate and finished SHG was -0.45 kg (-0.47, -0.43) and -1.32 kg (-1.39, -1.25) in men, and -0.66 kg (-0.72, -0.60) and -1.68 kg (-1.87, -1.49) in women, respectively. Higher support points and larger body sizes correlated with greater reductions in BW in men (P＜0.001), but the associations were not significant in women. The reduction in WC was greater in women with normal weight than in obese women.Conclusion: Sex differences were observed in the association between BW/WC reduction and body size or the amount of support given during SHG.","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"589-606"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence-based Specific Health Guidance for Obese Individuals with Cardiovascular Risk Factors to Reduce Weight and Waist Circumference. 有心血管危险因素的肥胖个体减少体重和腰围的循证健康指导

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-05-01 Epub Date: 2026-03-25 DOI: 10.5551/jat.ED305

Rumi Tsukinoki

引用次数: 0

A Catalog of the Pathogenic Variants in ABCG5 and ABCG8 and Clinical Features in Sitosterolemia. ABCG5和ABCG8致病变异目录及谷固醇血症的临床特征。

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-05-01 Epub Date: 2026-02-11 DOI: 10.5551/jat.RV22049

Takeshi Okada, Shizuya Yamashita, Hayato Tada, Kazuhisa Tsukamoto, Masako Togo, Masa-Aki Kawashiri, Kimitoshi Nakamura, Kazushige Dobashi, Katsunori Ikewaki, Hiroshi Yoshida, Mariko Harada-Shiba

{"title":"A Catalog of the Pathogenic Variants in ABCG5 and ABCG8 and Clinical Features in Sitosterolemia.","authors":"Takeshi Okada, Shizuya Yamashita, Hayato Tada, Kazuhisa Tsukamoto, Masako Togo, Masa-Aki Kawashiri, Kimitoshi Nakamura, Kazushige Dobashi, Katsunori Ikewaki, Hiroshi Yoshida, Mariko Harada-Shiba","doi":"10.5551/jat.RV22049","DOIUrl":"10.5551/jat.RV22049","url":null,"abstract":"Aim: Since comprehensive data on the pathogenic variants of ABCG5 and ABCG8 and clinical features in sitosterolemia remain limited, we aimed to compile a catalog through an extensive literature search of case reports from 2002 to 2024, as well as an evaluation of variants reported in review articles.Methods: We compiled 155 cases of sitosterolemia from 133 families with nonsynonymous variants in ABCG5 and ABCG8, along with data on clinical information from case reports. Pathogenic variants were defined either as 1) protein-truncating variants, 2) classified as pathogenic or likely pathogenic variants according to the ACMG guidelines, or 3) serum sitosterol level of the case was measured at ≥ 1 mg/dL.Results: Xanthoma was observed in 69.2% of patients, ischemic heart disease in 14.2%, and hematologic abnormalities in 57.9%. Fifty-three variants in ABCG5 and 52 in ABCG8 were evaluated for their pathogenicity, in which 33 in ABCG5 and 29 in ABCG8 were protein-truncating variants. Additionally, based on the ACMG criteria and serum sitosterol levels, 50 variants in ABCG5 and 51 variants in ABCG8 were finally classified as pathogenic. Among them, the frequently observed R446X and R389H in ABCG5 were highly prevalent in East Asians, while W361X and S107X in ABCG8 were predominantly found in Europeans.Conclusion: We provided the largest catalog of clinical features and pathogenic variants of ABCG5 and ABCG8 in the world. This study may help clarify the pathogenicity of variants in ABCG5 and ABCG8 and provide a valuable reference for the genetic diagnosis of sitosterolemia.","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"538-558"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Lp(a) Help to Identify High-risk Plaques? Lp(a)有助于识别高危斑块吗？

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-05-01 Epub Date: 2026-02-17 DOI: 10.5551/jat.ED301

Yu Kataoka

引用次数: 0

Long-term Safety and Efficacy of Bempedoic Acid in Japanese Patients with Hypercholesterolemia: the CLEAR-J LONG. 本培多酸治疗日本高胆固醇血症患者的长期安全性和有效性：CLEAR-J LONG。

IF 3.4 2区医学

Journal of atherosclerosis and thrombosis Pub Date : 2026-04-01 Epub Date: 2025-11-28 DOI: 10.5551/jat.65947

Daisaku Masuda, Kouji Kajinami, Nobutaka Sakayoshi, Daisuke Yokota, Masakazu Nagamine, Yuki Morikawa-Isogai, Shizuya Yamashita

{"title":"Long-term Safety and Efficacy of Bempedoic Acid in Japanese Patients with Hypercholesterolemia: the CLEAR-J LONG.","authors":"Daisaku Masuda, Kouji Kajinami, Nobutaka Sakayoshi, Daisuke Yokota, Masakazu Nagamine, Yuki Morikawa-Isogai, Shizuya Yamashita","doi":"10.5551/jat.65947","DOIUrl":"10.5551/jat.65947","url":null,"abstract":"Aims: Bempedoic acid is an ATP citrate lyase (ACLY) inhibitor acting in the cholesterol biosynthesis pathway. This study evaluated long-term safety and efficacy of bempedoic acid 180 mg/day for 52 weeks in Japanese patients with hypercholesterolemia.Methods: A multicenter, open-label, single-arm Phase 3 long-term study was conducted at 26 hospitals and clinics across Japan in patients aged 18 to 85 years. Newly enrolled patients had previously failed to achieve their lipid management targets because of inadequate response to statins or statin intolerance; rollover patients had completed the 12-week treatment period of a domestic Phase 3 confirmatory study (the CLEAR-J trial) and had not met the discontinuation criteria at Week 12.Results: Bempedoic acid was administered to 130 patients. Treatment-emergent adverse events (TEAEs) occurred in 83.8%, treatment-related TEAEs in 14.6%, serious TEAEs in 6.2%, and AEs leading to discontinuation in 4.6%. None were severe. Between baseline and Week 52, low-density lipoprotein-cholesterol (LDL-C) decreased by 21.6% (overall population) and 25.3% (newly enrolled group), as observed in both statin response subgroups. LDL-C target levels based on risk category were achieved by 65.6% at Week 52 (overall population). Long-term efficacy was also demonstrated for non-high-density lipoprotein cholesterol, total cholesterol, apolipoprotein B, and high-sensitivity C-reactive protein.Conclusions: Bempedoic acid 180 mg/day for 52 weeks was well tolerated in patients with hypercholesterolemia, with no major safety concerns. Serious AEs were infrequent, and no new safety signals specific to the Japanese population were observed. More than 60% of patients achieved and sustained their LDL-C target levels.","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"449-469"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0