Journal of atherosclerosis and thrombosis最新文献

{"title":"Differential Effects of Direct Plasmin Inhibition and Tranexamic Acid on Atherosclerosis Progression and Vascular Remodeling in Apoe/Ldlr Double-Knockout Mice.","authors":"Natsumi Yoshihama, Nana Kurisu, Kentaro Shimatani, Kanae Hyodo, Naotaka Ohta, Hiromitsu Ishii, Tsutomu Yamashita","doi":"10.5551/jat.66328","DOIUrl":"https://doi.org/10.5551/jat.66328","url":null,"abstract":"<p><strong>Aim: </strong>The fibrinolytic system may protect against or promote atherosclerosis; however, the effects of distinct antifibrinolytic interventions on plaque development and extracellular matrix (ECM) remodeling remain unclear.</p><p><strong>Methods: </strong>We compared YO-2, a direct plasmin inhibitor, and tranexamic acid (TXA), a lysine analog that interferes with plasminogen/plasmin binding to fibrin, in Apoe/Ldlr double-knockout mice fed a Western diet. The atherosclerotic burden, plaque structure, vascular marker expression, leukocyte-endothelial interactions, and nitric oxide (NO)-related indices were assessed.</p><p><strong>Results: </strong>YO-2 significantly increased the atherosclerotic lesion area compared to the control, whereas TXA had minimal effects. The thrombolytic activity in the He-Ne laser-induced thrombosis model and NO-related indices did not differ significantly among the groups. Vascular t-PA expression increased in both treatment groups. YO-2 was associated with reduced uPAR and MMP-9 expression and preservation of the internal elastic lamina and medial elastin fibers, suggesting reduced pericellular ECM degradation. TXA increased PAI-1 and TAFI expression without altering uPAR. Both treatments significantly reduced leukocyte rolling, and the E-selectin expression was significantly decreased with YO-2, with a similar trend with TXA. eNOS mRNA expression was significantly higher in both groups, although the corresponding increase in the eNOS protein expression was only a non-significant trend.</p><p><strong>Conclusions: </strong>Direct plasmin inhibition with YO-2 aggravated atherosclerosis and it was associated with a reduced uPAR/MMP-9 expression and altered vascular ECM remodeling. TXA had limited effects on lesion burden while increasing PAI-1 and TAFI expression. These findings suggest that direct plasmin inhibition and TXA-mediated antifibrinolysis may differentially affect atherosclerosis and vascular remodeling.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological within-day Variation in Lipoprotein(a): Is a Once-in-a-lifetime Measurement Sufficient for Cardiovascular Risk Evaluation?","authors":"Shuxin Song, Satoshi Hirayama, Haruka Inaba, Atsushi Hori, Yuna Horiuchi, Yuri Ichikawa, Yutaka Kimura, Yoshifumi Fukushima, Tsuyoshi Ueno, Yuki Uehara, Takashi Miida","doi":"10.5551/jat.66290","DOIUrl":"https://doi.org/10.5551/jat.66290","url":null,"abstract":"<p><strong>Aims: </strong>Lipoprotein(a) (Lp(a)) is a strong risk factor for cardiovascular events, independent of low-density lipoprotein cholesterol (LDL-C). Because the Lp(a) concentration is largely determined by genetic factors, some dyslipidemia guidelines recommend a once-in-a-lifetime measurement of Lp(a). Furthermore, a non-fasting lipid profile assessment is allowed for initial screening of dyslipidemia. Although the LDL-C concentration decreases slightly throughout the day, the within-day variation of Lp(a) remains unknown. We aimed to investigate whether the Lp(a) concentration remains stable throughout the day.</p><p><strong>Methods: </strong>Lp(a) concentrations were measured at seven time points throughout the day in 34 patients using a latex turbidimetric immunoassay. The Lp(a) values are expressed in molar units, which are equivalent to those determined by a mass spectrometry-based reference measurement procedure.</p><p><strong>Results: </strong>We found that the Lp(a) concentrations decreased by 2.9±5.2 nmol/L at 14:00 (p＜0.05), 3.6±4.8 nmol/L at 20:00 (p＜0.001), and 2.9±5.1 nmol/L at 24:00 (p＜0.05). The mean percent Lp(a) decreased significantly at 17:30 (-6.2±0.1%) and 24:00 (-7.0±0.1%) from the fasting level.</p><p><strong>Conclusion: </strong>The Lp(a) concentration decreases slightly, but significantly, throughout the day. Considering physiological variations, it is preferable to re-evaluate the Lp(a) concentration in those with a borderline elevation.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Albuminuria and eGFR with Stiffness Parameter β in Type 2 Diabetes.","authors":"Susumu Nakatani, Tomoaki Morioka, Yoshinori Kakutani, Shoko Miyamoto, Yuka Natsuki, Yuya Miki, Masafumi Kurajoh, Shinya Nakatani, Masanori Emoto","doi":"10.5551/jat.66371","DOIUrl":"https://doi.org/10.5551/jat.66371","url":null,"abstract":"<p><strong>Aims: </strong>The stiffness parameter β is a clinical index of arterial stiffness that reflects systemic atherosclerosis. Chronic kidney disease (CKD) is a major cardiovascular risk factor in type 2 diabetes; however, it remains unclear whether a reduced kidney function or albuminuria is more strongly associated with arterial stiffness. This study examined the relative associations of estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) with stiffness parameter β in patients with type 2 diabetes.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 1,924 patients with type 2 diabetes. The stiffness parameter β was assessed at the common carotid artery using ultrasonography.</p><p><strong>Results: </strong>The participants were 58.8% male, with a median age of 63 years and a median HbA1c level of 8.3%. According to univariate analyses, stiffness parameter β was significantly correlated with both eGFR and UACR. However, after adjusting for conventional cardiovascular risk factors, stiffness parameter β remained independently associated with UACR, whereas no independent association was observed with eGFR. Similar findings were observed when eGFR and albuminuria were analyzed according to the CKD categories. No significant interactions were observed between UACR and either age or body mass index in relation to stiffness parameter β.</p><p><strong>Conclusions: </strong>In patients with type 2 diabetes, albuminuria, but not eGFR, was independently associated with stiffness parameter β after multivariable adjustment. These findings suggest that albuminuria may serve as a marker of local carotid arterial stiffening and vascular injury.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) is Independently Associated with Polyvascular Disease Burden.","authors":"Ryotaro Yamada, Teruyoshi Kume, Hiroshi Okamoto, Yumi Matsutani, Kanako Ichiki, Yuya Murakami, Kaede Iteya, Yuuki Yamada, Masahiro Yamashita, Satoshi Koto, Kyo Kamisaka, Yoshitaka Sasahira, Tomoko Tamada, Terumasa Koyama, Koichiro Imai, Yoji Neishi, Shiro Uemura","doi":"10.5551/jat.66432","DOIUrl":"https://doi.org/10.5551/jat.66432","url":null,"abstract":"<p><strong>Aims: </strong>Lipoprotein(a) [Lp(a)] is an established, genetically determined risk factor for atherosclerotic cardiovascular disease. However, its association with the polyvascular disease burden remains unclear. This study investigated the relationship between the Lp(a) concentration and polyvascular disease burden.</p><p><strong>Methods: </strong>We retrospectively analyzed data from 1,799 patients who underwent Lp(a) measurements between 2012 and 2025. The polyvascular disease burden was assessed using a polyvascular score based on the presence of coronary artery disease, cerebrovascular disease, lower-extremity artery disease, aneurysmal aortic disease, and calcific aortic valve disease. Patients were categorized according to the number of affected disease domains (scores 0, 1, 2, 3, and ≥ 4). A multivariable ordinal logistic regression analysis was performed to identify the factors associated with an increasing polyvascular disease burden.</p><p><strong>Results: </strong>Patients with polyvascular disease (polyvascular score ≥1) had significantly higher Lp(a) concentrations than those without clinically overt vascular disease (57.9 [24.0-118.3] vs. 42.9 [20.2-76.8] nmol/L, P＜0.001). The Lp(a) concentrations increased progressively with increasing polyvascular scores, and the prevalence of elevated Lp(a) (≥ 125 nmol/L) increased stepwise across the score categories (both P＜0.001). In a multivariable ordinal logistic regression analysis adjusted for age, sex, hypertension, smoking history, family history of ischemic heart disease, eGFR, and LDL-C, higher Lp(a) levels remained independently associated with an increased polyvascular disease burden (OR 1.07 per 10 nmol/L increase, 95% CI 1.05-1.10; P＜0.001).</p><p><strong>Conclusions: </strong>Higher Lp(a) concentrations were independently associated with an increased polyvascular disease burden, suggesting that Lp(a) may reflect the extent of cardiovascular disease involvement across multiple disease domains.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet and Atherosclerosis Prevention: Rethinking the Significance of \"The Japan Diet\".","authors":"Chizuko Maruyama","doi":"10.5551/jat.RV22057","DOIUrl":"10.5551/jat.RV22057","url":null,"abstract":"<p><p>Although the mortality rate from cardiovascular disease (CVD) in Japan remains lower than that in Western countries, the need for the prevention of atherosclerotic diseases still merits emphasis. Cardiovascular disease develops due to the accumulation of risk factors such as visceral obesity, impaired glucose tolerance and diabetes, dyslipidemia, metabolic dysfunction associated with steatotic liver disease, hypertension, and chronic kidney disease. Dietary therapy must comprehensively improve these factors through the intake of nutrients and food components. This narrative review aims to confirm the effects of well-known nutrients that influence atherosclerotic risk factors and foods providing each nutrient in the Japanese diet. Furthermore, the actual dietary intake of the Japanese population is described. Target foods and dietary habits to modify patients' diets should be determined through nutrition assessment. Reducing carbohydrate intake requires limiting confectioneries, sweet beverages, and sweet fruits while avoiding the consumption of a lot of refined grains at once. The consumption of foods rich in saturated fatty acids, such as lard, beef tallow, butter, fatty red meat, fresh cream, and trans fatty acids contained in shortening, margarine, oily processed and fried foods, should be reduced. To meet the dietary fiber intake requirement, more unpolished grains, vegetables, citrus or whole fruits, seaweed, mushrooms, and konjac should be consumed. Fish intake is higher in Japan than in Western countries but it has been decreasing in younger generations, indicating the need for education and environments that encourage fish consumption for EPA and DHA intake and limit excess oil intake. Japanese people have higher candidate gene polymorphisms responsible for salt-sensitive hypertension than Caucasians; therefore, strict salt reduction is desirable. Sodium is included in salt, seasonings, and sodium salt additives in take-away, prepared, and ultra-processed foods, the cumulative impact of which cannot be ignored. The Japan Atherosclerosis Society (JAS) recommends a dietary pattern called \"The Japan Diet,\" featuring higher consumption of fish, soybeans and soy products, vegetables, citrus fruits, low-fat milk and dairy products, seaweed/mushrooms/konjak, and unrefined cereals with reduced consumption of animal fat, fatty meat and poultry, sweets including desserts and snacks, and alcoholic drinks, along with reduced salt intake. \"The Japan Diet\", a reasonable and useful strategy for nutrition therapy, improves multiple atherosclerotic risk factors comprehensively by providing prescribed nutrients. Nutrition education for \"The Japan Diet\" intake improved serum lipid and metabolic parameters in patients with dyslipidemia. However, clinical intervention studies on patients with atherosclerotic risk factors remain limited. Further studies on the effect of \"The Japan Diet\" on CVD prevention are needed.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1246-1258"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum ADAMTS18 Levels at Admission Are Associated With 3-Month Functional Outcome After Acute Ischemic Stroke.","authors":"Ting Cui, Huan Wang, Yuyi Zhu, Mingxi Chen, Yaqi Chen, Keying Wu, Junfeng Liu, Zilong Hao, Bo Wu, Deren Wang","doi":"10.5551/jat.66202","DOIUrl":"10.5551/jat.66202","url":null,"abstract":"<p><strong>Aims: </strong>ADAMTS18 is a secreted metalloproteinase implicated in vascular homeostasis and protection against ischemic brain injury. However, its clinical relevance in acute ischemic stroke (AIS) remains unclear.</p><p><strong>Methods: </strong>We retrospectively analyzed 194 AIS patients from the Chengdu Stroke Registry. Serum ADAMTS18 levels were measured within 48 hours of admission using ELISA. Associations between ADAMTS18 levels and 3-month poor outcomes (modified Rankin Scale score 3-6) were evaluated using logistic regression. Predictive performance was assessed using area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI).</p><p><strong>Results: </strong>Among 194 patients, the median ADAMTS18 was 21.45 ng/mL (IQR 19.68-23.58 ng/mL), 79 (40.7%) had poor outcomes. Patients with poor outcomes had lower serum ADAMTS18 levels [19.84 (18.46-21.24) vs. 22.88 (21.14-24.81) ng/mL, P＜0.001]. After adjustment, lower ADAMTS18 levels were independently associated with poor outcome (OR 0.70, 95% CI 0.58-0.83, P＜0.001). Quartile analysis showed that compared with the lowest quartile, patients in Q3 (OR = 0.26; 95% CI: 0.08-0.83; P = 0.023) and Q4 (OR = 0.02; 95% CI: 0.00-0.11; P＜0.001) had progressively lower odds of poor functional outcome (P for trend ＜0.001). Restricted cubic spline analysis confirmed a negative linear association (adjusted P_overall＜0.001). Incorporating ADAMTS18 into predictive models improved discrimination (AUC = 0.91 vs. 0.86, P = 0.011), IDI (11.14%, P＜0.001), and NRI (77.1%, P＜0.001).</p><p><strong>Conclusion: </strong>Lower admission ADAMTS18 levels are independently associated with poor 3-month functional outcomes after AIS and may provide additional prognostic information.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1300-1309"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATP Inside and Out: Understanding Atherosclerosis Through Energy Metabolism and Purinergic Signaling.","authors":"Osamu Baba, Koh Ono","doi":"10.5551/jat.RV22054","DOIUrl":"10.5551/jat.RV22054","url":null,"abstract":"<p><p>Adenosine triphosphate (ATP) is well known as the major intracellular energy carrier. It also functions as a potent extracellular signaling molecule. In atherosclerosis, both intracellular and extracellular ATP have been increasingly implicated in the disease pathophysiology. The intracellular ATP levels are closely regulated by the balance among the metabolic pathways, including glycolysis and oxidative phosphorylation (OXPHOS), and they play diverse and cell type-specific roles in atherosclerotic plaques. In contrast, the extracellular ATP released from these cells binds to purinergic P2 receptors and activates downstream signaling cascades primarily in an autocrine or paracrine manner, thereby regulating various cellular functions during disease progression. These two contrasting ATP-associated pathways are involved in a wide range of atherosclerosis-related processes including inflammation, vascular tone and barrier function, cell proliferation, migration and differentiation, and calcification, some of which are shared or highly context-dependent. This review summarizes the fundamental aspects of ATP biology, discusses the current approaches for measuring ATP concentrations in atherosclerotic plaques, and highlights the functions of intra- and extracellular ATP in major atherosclerosis-related cell types, including endothelial cells, macrophages and vascular smooth muscle cells (VSMCs), to clarify these intricately intertwined pathophysiological processes. Finally, this overview provides insights into the current challenges in ATP biology research and outlines therapeutic opportunities targeting intra- or extracellular ATP in atherosclerotic disease.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1207-1219"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Lipids and Glaucoma.","authors":"Atsuya Miki","doi":"10.5551/jat.ED308","DOIUrl":"10.5551/jat.ED308","url":null,"abstract":"","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1259-1260"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Sinus Rhythm: Rhythm Control and Mechanism-Based Secondary Prevention in Atrial Fibrillation-Related Stroke.","authors":"Yasuhiro Nishiyama","doi":"10.5551/jat.RV22055","DOIUrl":"10.5551/jat.RV22055","url":null,"abstract":"<p><p>Atrial fibrillation is one of the most important causes of ischemic stroke and it is strongly associated with recurrent stroke, systemic embolism, heart failure, cognitive decline, and mortality. Oral anticoagulation, preferably direct oral anticoagulants, remains the cornerstone of secondary stroke prevention in patients with atrial fibrillation and a history of ischemic stroke. However, ischemic stroke may still occur despite appropriate anticoagulation therapy, a condition often referred to as breakthrough ischemic stroke. This residual risk reflects heterogeneous mechanisms, including inadequate anticoagulant exposure, atrial cardiomyopathy, left atrial appendage thrombus, large-artery atherosclerosis, small-vessel disease, cancer-associated thrombosis, and other competing etiologies. Rhythm control has re-emerged as a disease-modifying strategy after the EAST-AFNET 4 trial, and its prespecified subgroup analysis suggested a potential benefit in patients with prior stroke. However, the recently reported STABLED randomized clinical trial, which specifically evaluated catheter ablation in addition to edoxaban-based standard therapy after a recent ischemic stroke, did not demonstrate a significant reduction in recurrent ischemic stroke, systemic embolism, all-cause mortality, or hospitalization for heart failure. These findings do not negate the value of rhythm control for symptom relief, atrial fibrillation burden reduction, and selected cardiovascular outcomes; however, they challenge the assumption that the restoration of sinus rhythm alone is sufficient for secondary stroke prevention. Future strategies should integrate optimized anticoagulation and early rhythm control when appropriate, with a systematic evaluation of competing stroke mechanisms, vascular risk factor control, and selected left atrial appendage interventions. The next frontier is not rhythm control alone but rhythm control embedded within mechanism-based secondary stroke prevention.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1220-1231"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Ambient Temperature on the Cardiovascular and Cerebrovascular Disease Incidence during 2009-2023 in Zhanjiang, Guangdong, China.","authors":"Shanshan Fan, Jilin Wang, Mingyi Tang, Juncheng Liu, Yinuo Shen, Yanyan Yang, Yufei Feng, Bohan Wang, Haoxin Chen, Wenxin Liu","doi":"10.5551/jat.66035","DOIUrl":"10.5551/jat.66035","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effects of temperature exposure on the incidence of cardiovascular and cerebrovascular diseases in Zhanjiang, a subtropical coastal city in China.</p><p><strong>Methods: </strong>We analyzed hospitalization data from 2009 to 2023 using generalized additive models (GAMs) and distributed lag nonlinear models (DLNMs) to examine the exposure-response relationships and lagged effects of daily maximum temperature on stroke (CVA), acute coronary syndrome (ACS), and acute aortic syndrome (AAS).</p><p><strong>Results: </strong>Distinct temperature-associated risk patterns were observed for each disease type. ACS showed the strongest association, with significant risk increases at 1-day (relative risk [RR] = 1.19) and 5-day lags (RR = 1.12). The risk of CVA was moderately elevated at lower temperatures (22.7℃; RR = 1.08), whereas AAS exhibited a delayed peak at 5 days (RR = 1.29).</p><p><strong>Conclusions: </strong>These subtropical patterns differ from those reported in temperate regions. Our findings support climate-specific warnings: namely, multi-day monitoring for CVA at lower temperatures, immediate and sustained alerts for ACS, and focused surveillance approximately 5 days after exposure for AAS.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"1285-1299"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}