Association of Visceral Fat Accumulation with Endothelial Glycocalyx Degradation in People with and without Type 2 Diabetes: A Retrospective Cross-sectional Study.

IF 2.8 2区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of atherosclerosis and thrombosis Pub Date : 2025-07-26 DOI:10.5551/jat.65623

Shoko Miyamoto, Yoshinori Kakutani, Tomoaki Morioka, Yuko Yamazaki, Akinobu Ochi, Shinya Fukumoto, Tetsuo Shoji, Masanori Emoto

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Abstract

Aim: Serum syndecan-1 (SDC-1) concentration is a biomarker for endothelial glycocalyx (EG) degradation, which is elevated in type 2 diabetes (T2D). EG degradation is an early step in vascular endothelial dysfunction. This study investigated the association between serum SDC-1 concentration and visceral fat accumulation, which is closely related to vascular endothelial dysfunction, in people with and without T2D.

Methods: This was a cross-sectional study with two independent groups, one including 219 individuals without diabetes (ND) and the other including 203 individuals with T2D. Visceral fat accumulation was assessed as the visceral fat area (VFA) using computed tomography (CT) in ND or dual bioelectrical impedance analysis (BIA) in T2D. Multivariate analyses were performed for ND and T2D to assess the association between VFA and serum SDC-1 concentrations.

Results: The medians of serum SDC-1 concentration were 16.0 ng/mL and 26.5 ng/mL in ND and T2D, respectively. In the univariate analysis, both CT-VFA in the ND group and BIA-VFA in the T2D group were positively correlated with serum SDC-1 concentration. Moreover, the association between VFAs and serum SDC-1 concentration was independent of other covariates in multivariate analysis for each group. However, neither the body mass index nor subcutaneous fat area were associated with serum SDC-1 concentrations in either group.

Conclusions: CT-VFA and BIA-VFA were independently associated with serum SDC-1 concentrations. Our findings suggest that visceral fat accumulation is involved in the degradation of EG irrespective of the presence of T2D.

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2型糖尿病患者和非2型糖尿病患者内脏脂肪积累与内皮糖萼降解的关联：一项回顾性横断面研究

目的：血清syndecan-1 （SDC-1）浓度是内皮糖萼（EG）降解的生物标志物，在2型糖尿病（T2D）中升高。EG降解是血管内皮功能障碍的早期步骤。本研究探讨了t2dm患者血清SDC-1浓度与内脏脂肪堆积之间的关系，而内脏脂肪堆积与血管内皮功能障碍密切相关。方法：这是一项有两个独立组的横断面研究，一组包括219名无糖尿病（ND）的个体，另一组包括203名有T2D的个体。在ND时使用计算机断层扫描（CT）或在T2D时使用双生物电阻抗分析（BIA）评估内脏脂肪堆积为内脏脂肪面积（VFA）。对ND和T2D进行多变量分析，以评估VFA与血清SDC-1浓度之间的关系。结果：ND和T2D患者血清SDC-1浓度中位数分别为16.0 ng/mL和26.5 ng/mL。在单因素分析中，ND组的CT-VFA和T2D组的BIA-VFA均与血清SDC-1浓度呈正相关。此外，在多变量分析中，各组VFAs和血清SDC-1浓度之间的关联独立于其他协变量。然而，在两组中，体重指数和皮下脂肪面积都与血清SDC-1浓度无关。结论：CT-VFA和BIA-VFA与血清SDC-1浓度独立相关。我们的研究结果表明，无论是否存在T2D，内脏脂肪积累都参与了EG的降解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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