Serum Total Cholesterol and Fatal Subarachnoid Hemorrhage in 120,000 Japanese: A Pooled Analysis of Data from 12 Cohorts.

IF 2.8 2区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of atherosclerosis and thrombosis Pub Date : 2025-05-24 DOI:10.5551/jat.65650

Atsushi Satoh, Hisatomi Arima, Sachiko Tanaka-Mizuno, Akira Fujiyoshi, Aya Kadota, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, Yoshitaka Murakami

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Abstract

Aim: The aim of this study was to clarify the association between serum total cholesterol and fatal subarachnoid hemorrhage in Japanese men and women.

Methods: The study involved a pooled analysis of individual data from 12 well-qualified cohort studies conducted in Japan. The participants were classified according to their serum total cholesterol levels: ＜4.14 mmol/L (＜160 mg/dL), 4.14-4.64 mmol/L (160-180 mg/dL), 4.65-5.16 mmol/L (180-199 mg/dL), 5.17-5.68 mmol/L (200-219 mg/dL), 5.69-6.20 mmol/L (220-239 mg/dL), and ≥ 6.21 mmol/L (≥ 240 mg/dL). The outcome of the analysis was death from subarachnoid hemorrhage.

Results: A total of 120,973 participants (70,947 women and 50,026 men) aged 18-96 years at baseline underwent follow-up for a median of 12.7 years, and 261 participants died from subarachnoid hemorrhage during this period. In women, both low (＜5.69 mmol/L [＜220 mg/dL]) and high (≥ 6.21 mmol/L [≥ 240 mg/dL]) serum total cholesterol levels were significantly associated with a higher risk of fatal subarachnoid hemorrhage compared with the reference group (5.69-6.20 mmol/L [220-239 mg/dL]). These associations remained significant after adjustment for confounding factors. In contrast, no associations were observed in men.

Conclusion: Both low and high serum total cholesterol levels were associated with a higher risk of fatal subarachnoid hemorrhage in 70,947 female participants from 12 cohort studies throughout Japan.

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12万日本人血清总胆固醇与致命性蛛网膜下腔出血：来自12个队列数据的汇总分析

目的：本研究的目的是阐明血清总胆固醇与日本男性和女性致死性蛛网膜下腔出血之间的关系。方法：本研究对日本进行的12项合格队列研究的个体数据进行了汇总分析。参与者根据血清总胆固醇水平分为：<4.14 mmol/L （<160 mg/dL）、4.14-4.64 mmol/L （160-180 mg/dL）、4.65-5.16 mmol/L （180-199 mg/dL）、5.17-5.68 mmol/L （200-219 mg/dL）、5.69-6.20 mmol/L （220-239 mg/dL）和≥6.21 mmol/L（≥240 mg/dL）。分析结果为蛛网膜下腔出血死亡。结果：共有120,973名参与者（70,947名女性和50026名男性）在基线时年龄为18-96岁，随访时间中位数为12.7年，261名参与者在此期间死于蛛网膜下腔出血。在女性中，与对照组（5.69-6.20 mmol/L [220-239 mg/dL]）相比，低（<5.69 mmol/L [<220 mg/dL]）和高（≥6.21 mmol/L[≥240 mg/dL]）血清总胆固醇水平均与致死性蛛网膜下腔出血的高风险显著相关。在校正混杂因素后，这些关联仍然显著。相比之下，在男性中没有观察到任何关联。结论：在日本12项队列研究的70,947名女性参与者中，低和高血清总胆固醇水平与致死性蛛网膜下腔出血的高风险相关。

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