Journal of atherosclerosis and thrombosis最新文献

{"title":"Ligand-Specific Notch Signaling in Atherosclerosis: Implications for Inflammation and Plaque Stability.","authors":"Oyunbileg Bavuu, Daiju Fukuda","doi":"10.5551/jat.ED306","DOIUrl":"10.5551/jat.ED306","url":null,"abstract":"","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"675-677"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Optimal Antiplatelet Therapy in Acute Ischemic Stroke: What Can We Learn from a Post Hoc Subgroup Analysis of the ACUTE-PRAS Study?","authors":"Yoshinobu Wakisaka, Tetsuro Ago","doi":"10.5551/jat.ED304","DOIUrl":"10.5551/jat.ED304","url":null,"abstract":"","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"678-680"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Assessment of Genetic and Epigenetic Contributions to the Plasma Lipid Levels with Respect to Cardiovascular Risk.","authors":"Fumihiko Takeuchi, Masaya Yamamoto, Masahiro Nakatochi, Kozue Takano, Atsuko Okazaki, Sakurako Emoto, Yasuharu Tabara, Tomohiro Katsuya, Ken Yamamoto, Masato Isono, Kotaro Mori, Tatsuaki Matsubara, Sahoko Ichihara, Mitsuhiro Yokota, Hisao Hara, Yukio Hiroi, Norihiro Kato","doi":"10.5551/jat.66000","DOIUrl":"10.5551/jat.66000","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to develop a model to simultaneously assess the genetic and epigenetic contributions to plasma lipids.</p><p><strong>Methods: </strong>The study used two cardiovascular risk groups: individuals with high low-density lipoprotein cholesterol (LDL-C) levels (N = 296) and coronary artery disease (CAD) (N = 315), in contrast to the reference (max N = 3,801) and non-CAD individuals (N = 164). For genetic predisposition, rare pathological variants in five target genes related to familial hypercholesterolemia (FH) were screened, while common variants were characterized to calculate a polygenic risk score (PRS). The methylation risk score (MRS) was also calculated for the epigenetic profile based on the DNA methylation levels at the 17 CpG sites. The relationship between each lipid level and these variables was analyzed using regression and quantile models.</p><p><strong>Results: </strong>Functionally significant rare variants were identified more frequently in patients with high LDL-C or CAD than in the general Japanese population (3.8% vs. 2.3%). For LDL-C, the model incorporating both PRS_LDL-C (plus rare variants) and MRS_LDL-C showed a higher correlation between the predicted and measured values (r = 0.272, P = 3.7×10^-12) than those using PRS_LDL-C alone (r = 0.106, P = 0.008) and PRS_LDL-C plus rare variants (r = 0.263, P = 1.9×10^-11). PRS and MRS had the most significant impact on high-density lipoprotein cholesterol and triglycerides, respectively; the two risk scores had additive effects on these lipid traits, as well as LDL-C.</p><p><strong>Conclusion: </strong>Our results provide a proof-of-concept that assesses the relative contribution of genetic predisposition and DNA methylation levels, which may help individuals refine their dyslipidemia treatment.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"717-758"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146219868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Pemafibrate on Fibrinogen and Thrombogenicity in Patients with Coronary Artery Disease.","authors":"Masanobu Ishii, Koichiro Fujisue, Koichi Kaikita, Kenshi Yamanaga, Shinsuke Hanatani, Yasushi Matsuzawa, Mitsutoshi Miura, Takashi Kudo, Hideki Shimomura, Masafumi Takae, Yuichiro Shirahama, Nobuyasu Yamamoto, Teruhiko Ito, Ryusuke Tsunoda, Eiji Horio, Tomohiro Sakamoto, Taku Rokutanda, Kenji Morihisa, Katsuo Noda, Hiroki Tanaka, Yunosuke Matsuura, Eiichiro Yamamoto, Yasuhiro Izumiya, Kenichi Tsujita","doi":"10.5551/jat.65984","DOIUrl":"10.5551/jat.65984","url":null,"abstract":"<p><strong>Aims: </strong>Pemafibrate effectively reduces the triglyceride levels in patients with coronary artery disease (CAD). However, its effect on the fibrinogen levels in these patients remains unclear. This study aimed to investigate the effects of pemafibrate on thrombogenicity and the plasma fibrinogen levels in patients complicated by hypertriglyceridemia.</p><p><strong>Methods: </strong>This multicenter, randomized, controlled trial enrolled 101 patients with hypertriglyceridemia (fasting triglycerides ≥ 150 mg/dL) and CAD who received antiplatelet monotherapy and statin therapy. After exclusion, 98 participants were randomly assigned to receive either pemafibrate 0.1 mg twice daily (intervention group) or standard care without any additional lipid-lowering therapy (control group), and 96 patients were analyzed. The fibrinogen levels were assessed at the baseline and after 12 weeks of treatment. The primary endpoint was the change in the fibrinogen level from baseline to week 12. The secondary endpoints included thrombogenicity measured using the Total Thrombus-formation Analysis System (T-TAS).</p><p><strong>Results: </strong>Among the 96 patients, the median baseline fasting triglyceride, HDL cholesterol, LDL cholesterol, and fibrinogen levels were 175 mg/dL, 45 mg/dL, 72 mg/dL, and 299 mg/dL, respectively. The median decrease in triglycerides from baseline to 12 weeks was greater in the pemafibrate group than in the control group (-62 mg/dL vs. -5 mg/dL, p＜0.001), as was the median decrease in fibrinogen (-58 mg/dL vs. 9 mg/dL, p＜0.001).</p><p><strong>Conclusions: </strong>Pemafibrate significantly reduced fibrinogen levels in patients with CAD and hypertriglyceridemia, thus highlighting its primary benefit in lowering thrombotic risk.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"759-774"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Low LDL-C Level but not Statin Use is Associated with In-hospital Mortality in Spontaneous Intracerebral Hemorrhage; The J-ICH Registry.","authors":"Kazo Kanazawa, Nobukazu Miyamoto, Hideaki Ueno, Satoshi Tsutsumi, Rikizo Saito, Joji Tokugawa, Yuji Ueno, Kazuo Yamashiro, Munetaka Yamamoto, Yukimasa Yasumoto, Makoto Hishii, Takuji Yamamoto, Chikashi Maruki, Takao Urabe, Akihide Kondo, Hajime Arai, Nobutaka Hattori, Ryota Tanaka","doi":"10.5551/jat.65992","DOIUrl":"10.5551/jat.65992","url":null,"abstract":"<p><strong>Aim: </strong>A reduction in low-density lipoprotein cholesterol (LDL-C) is beneficial for vascular diseases; however, lower LDL-C levels may be associated with an increased risk of spontaneous intracerebral hemorrhage (sICH). The present study investigated the relationship between the LDL-C levels and in-hospital mortality after sICH using data from the Juntendo Registry of Spontaneous Intra-Cerebral Hemorrhage (J-ICH registry).</p><p><strong>Methods: </strong>Patients aged ≥ 20 years with non-traumatic sICH admitted to five Juntendo-affiliated hospitals between September 2016 and December 2019 were enrolled in this study. The relationships between the LDL-C levels and in-hospital mortality, statin therapy, and antithrombotic therapy were analyzed.</p><p><strong>Results: </strong>Among the 1,017 patients with sICH, lower LDL-C levels were associated with older age, a lower BMI, a larger hematoma volume, more severe neurological deficits, and a higher in-hospital mortality. A logistic regression analysis confirmed that LDL-C ＜100 mg/dL independently increased the risk of in-hospital death, along with age, the NIHSS score, hematoma volume, and intraventricular hemorrhage. Subgroup analyses showed that the association between low LDL-C levels and mortality was particularly evident in patients with deep/infratentorial intracerebral hemorrhage, those managed without surgery, and those without prior statin use. Prior statin use was associated with a potential protective effect against in-hospital mortality and hematoma volume.</p><p><strong>Conclusion: </strong>This study demonstrated that lower LDL-C levels were associated with a higher in-hospital mortality after sICH, whereas prior statin use was not associated with poorer outcomes and may instead offer a protective effect.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"835-848"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dietary Fiber Intake and the Risk of Disabling Dementia: The JPHC Disabling Dementia Study.","authors":"Shoko Aoki, Kazumasa Yamagishi, Isao Muraki, Tomomi Kihara, Junko Ishihara, Hiroyasu Iso, Nobufumi Yasuda, Manami Inoue, Shoichiro Tsugane, Norie Sawada","doi":"10.5551/jat.65864","DOIUrl":"10.5551/jat.65864","url":null,"abstract":"<p><strong>Aim: </strong>We evaluated the association between the dietary fiber intake and the risk of dementia.</p><p><strong>Methods: </strong>We performed a prospective study within the Japan Public Health Center-based Prospective Study involving 41,467 Japanese individuals aged 45-74 years between 1995-1998. Information regarding food intake was collected using a food frequency questionnaire. Disabling dementia was detected using the National Long-term Insurance System between 2006 and 2016. We calculated the hazard ratios and 95% confidence intervals for disabling dementia according to quartiles of soluble, insoluble, and total fiber intake and dietary fiber intake from food groups (cereals, potatoes and starches, soybeans, vegetables, and fruits) intake by sex.</p><p><strong>Results: </strong>During an average follow-up period of 9.4, 4910 cases of disabling dementia were documented. The total fiber intake was inversely associated with the risk of disabling dementia in both men and women. The multivariable hazard ratios (95% confidence intervals: CIs) of disabling dementia for the highest versus lowest quartiles of total fiber intake were 0.82 (0.73-0.91) in women (p for trend ＜0.001) and 0.86 (0.74-1.00) in men (p for trend = 0.03). Similar inverse associations between soluble and insoluble fiber intake and the risk of disabling dementia were observed. The dietary fiber intake from cereals, potatoes, starches, vegetables, and fruits, but not soybeans, was inversely associated with the risk of disabling dementia, with some variation by sex.</p><p><strong>Conclusions: </strong>The dietary intake of total, soluble, and insoluble fiber was associated with a lower risk of disabling dementia. The associations did not vary materially according to the food source of the fiber.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":"33 5","pages":"607-618"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Familial Hypercholesterolemia: Your Feet can Help Predict Your Coronary Atherosclerosis.","authors":"Masa-Aki Kawashiri, Hayato Tada","doi":"10.5551/jat.ED303","DOIUrl":"10.5551/jat.ED303","url":null,"abstract":"","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"562-563"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PGC-1β Mediates the Atheroprotective Roles of β-Aminoisobutyric Acid (BAIBA) in Vascular Endothelial Cells.","authors":"Hiroyasu Yamamoto, Ayano Ishii, Shinji Kihara","doi":"10.5551/jat.66011","DOIUrl":"10.5551/jat.66011","url":null,"abstract":"<p><strong>Aims: </strong>Physical exercise exerts antiatherosclerotic effects through several mechanisms. One anti-inflammatory effect of exercise is directly exerted on vascular endothelial cells by β-aminoisobutyric acid (BAIBA), which is released from the skeletal muscles during physical activity. The increased expression of estrogen-related receptor α (ERRα) and peroxisome proliferator-activated receptor-gamma co-activator (PGC)-1β also plays a role in these mechanisms. However, the underlying mechanisms remain unknown, and we aimed to explore the effects of PGC-1β on the endothelial function.</p><p><strong>Methods: </strong>We generated human umbilical vein endothelial cells (HUVECs) with PGC-1β knockdown using siRNA or by inducing the overexpression of PGC-1β using an adenovirus. We then examined the expression of inflammation-related genes induced by tumor necrosis factor α (TNFα) using qRT-PCR and the expression of endothelial nitric oxide synthase (eNOS) and its activation-related proteins using a western blot analysis.</p><p><strong>Results: </strong>BAIBA treatment suppressed the TNFα-induced expression of inflammation-related molecules in HUVECs. However, these protective effects were diminished following PGC-1β knockdown, which correlated with decreased levels of IκBα protein. Additionally, in PGC-1β knockdown-HUVECs, the total and phosphorylated levels of eNOS decreased along with the levels of active AMP-activated protein kinase (AMPK) and protein kinase B (Akt). Conversely, the overexpression of PGC-1β in HUVECs resulted in the opposite effect.</p><p><strong>Conclusion: </strong>These results suggest that BAIBA exerts various protective effects on vascular endothelial cells through the PGC-1β-NFκB and PGC-1β-AMPK-Akt-eNOS axes.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"619-631"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Step Clinical Pathways to Cardiovascular Mortality in Chronic Kidney Disease and Dialysis -- A Narrative Review.","authors":"Tetsuo Shoji, Christoph Wanner","doi":"10.5551/jat.RV22048","DOIUrl":"10.5551/jat.RV22048","url":null,"abstract":"<p><p>Patients with chronic kidney disease (CKD) face a markedly elevated risk of death from cardiovascular disease (CVD); in particular, those requiring hemodialysis have a 10- to 30-fold higher risk than the general population. This extremely increased risk of CVD death reflects the coexistence of multiple traditional and nontraditional risk factors. The present narrative review considers two distinct steps: first, the occurrence of a CVD event, and second, death resulting from an inability to recover from the CVD event. Patients undergoing hemodialysis are at an increased risk for both of these steps, accounting for the dramatically higher risk of CVD death in this population. High risk for the second step-death following a CVD event-may be driven by conditions called decreased physical resilience and increased frailty. Studies of patients on hemodialysis show that predictors for death at this stage include key components of malnutrition-inflammation-atherosclerosis syndrome-also called the malnutrition-inflammation-complex-syndrome or protein-energy wasting-such as lower body mass index, lower serum albumin, and higher C-reactive protein. Other important contributors include higher age, longer dialysis duration, diabetic kidney disease, phosphate, calcium, serum calcification propensity (T50), and insulin-like growth factor 1 levels. Notably, some of these factors also predict death following infection, suggesting that the risk predictors for the second step are shared between CVD and infection. Recognizing these steps may facilitate prevention and greater preparedness for CVD, infection, and other stressful events among patients with CKD.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"521-537"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Lipoprotein(a) Combined with the Suita Score for High-Risk Plaque in Japanese Patients.","authors":"Yudai Niwa, Hiroyuki Naruse, Hideki Kawai, Eirin Sakaguchi, Yuya Ishihara, Hidekazu Hattori, Komei Uehara, Masaki Ito, Shingo Yamada, Akira Yamada, Takashi Muramatsu, Fumihiko Kitagawa, Hiroshi Takahashi, Junnichi Ishii, Masayoshi Sarai, Masanobu Yanase, Yukio Ozaki, Kuniaki Saito, Hideo Izawa","doi":"10.5551/jat.65904","DOIUrl":"10.5551/jat.65904","url":null,"abstract":"<p><strong>Aims: </strong>The global distribution of lipoprotein(a) [Lp(a)] levels varies due to racial and ethnic differences. However, the clinical relevance of Lp(a) levels in Japanese patients has not been fully explored.</p><p><strong>Methods: </strong>We investigated the association of Lp(a) levels, the Suita score, and the presence of high-risk plaque (HRP) as well as that of ≥ 50% stenosis, quantitative plaque volume, and the value of coronary artery calcium score in coronary computed tomographic angiography (CCTA), among 272 Japanese patients (mean age: 65 years) in whom serum Lp(a) levels were measured due to suspected coronary artery disease. HRP was defined as positive remodeling and/or low attenuation. Plaque volume was quantified as the percent plaque volume.</p><p><strong>Results: </strong>HRP was identified in 33 (12.1%) patients. The prevalence of HRP, ≥ 50% stenosis, and percent plaque volume progressively increased with higher Lp (a) levels and Suita scores. In multivariate analyses, Lp(a) and the Suita score independently predicted HRP when assessed as continuous (p = 0.02, p＜0.001, respectively) or categorical variables (p = 0.005, p = 0.007, respectively). Patients in the highest tertile of Lp(a) and classified as high- or intermediate-risk by the Suita score had the highest HRP risk, whereas those in the lower 2 tertiles and low-risk group had the lowest. Incorporating Lp(a) into the Suita score improved the prediction of HRP beyond the Suita score alone (p = 0.005).</p><p><strong>Conclusions: </strong>The combinatorial value of assessing Lp(a) levels and Suita score may provide useful insight regarding Japanese patients undergoing CCTA for the prediction of HRP.</p>","PeriodicalId":15128,"journal":{"name":"Journal of atherosclerosis and thrombosis","volume":" ","pages":"566-577"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}