Journal of Asthma最新文献

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Mepolizumab reduced healthcare resource utilization and improved work productivity in patients with severe asthma during the REALITI-A 2-year study. 在REALITI-A为期2年的研究中,Mepolizumab降低了严重哮喘患者的医疗资源利用率并提高了工作效率。
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-29 DOI: 10.1080/02770903.2025.2558755
Giorgio Walter Canonica, Arnaud Bourdin, Erika Penz, Lingjiao Zhang, Peter Howarth, Rafael Alfonso-Cristancho
{"title":"Mepolizumab reduced healthcare resource utilization and improved work productivity in patients with severe asthma during the REALITI-A 2-year study.","authors":"Giorgio Walter Canonica, Arnaud Bourdin, Erika Penz, Lingjiao Zhang, Peter Howarth, Rafael Alfonso-Cristancho","doi":"10.1080/02770903.2025.2558755","DOIUrl":"10.1080/02770903.2025.2558755","url":null,"abstract":"<p><strong>Objective: </strong>To assess the real-world impact of mepolizumab on healthcare resource utilization (HCRU) and work productivity and activity impairment (WPAI) in patients with severe asthma.</p><p><strong>Methods: </strong>Asthma-related HCRU and WPAI were assessed over 2 years in the REALITI-A study-an international, prospective, observational cohort study in adults with severe asthma newly initiating mepolizumab (100 mg subcutaneous). Secondary endpoints of the study compared the proportion of patients with HCRU use, HCRU events, and WPAI component scores 12 months before mepolizumab initiation with 24 months follow-up. The relative rates of HCRU outcomes were calculated, with a treatment policy estimand for discontinuation.</p><p><strong>Results: </strong>Patients (<i>N</i> = 822) had a mean age of 54 years and 63% were female. Hospitalization rates were reduced by 53% in the 0-12-month follow-up period (<i>p</i> < 0.001) and sustained for 24 months. The rates of asthma-related hospitalizations, emergency department visits, and outpatient visits reduced by 59-64% (<i>p</i> < 0.001) across the 24-month follow-up. The mean number of overnight hospital stays reduced from 2.4 in the pre-treatment period to 1.0 and 0.5 in the 0-12-month and 12-24-month follow-up periods, respectively. The WPAI Asthma activity impairment score was reduced from baseline by 47% and 55% at 12 and 24 months of follow-up. Overall work impairment was reduced by 62% and 74%.</p><p><strong>Conclusions: </strong>Mepolizumab treatment reduced HCRU while improving activity and productivity in patients with severe asthma over 2 years. These data provide further evidence of real-world benefits of mepolizumab and may help inform healthcare system resource allocation.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measurement properties of the Patient-Specific Functional Scale in individuals with asthma. 哮喘患者特异性功能量表的测量特性。
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-25 DOI: 10.1080/02770903.2025.2562580
Stephany Costa Franco, Luan Dos Santos Mendes-Costa, Gabriela Bezerra de Almeida, Isabella de Melo Matos, Simone Castelo Branco Fortaleza, Felipe V C Machado, Rafael Mesquita
{"title":"Measurement properties of the Patient-Specific Functional Scale in individuals with asthma.","authors":"Stephany Costa Franco, Luan Dos Santos Mendes-Costa, Gabriela Bezerra de Almeida, Isabella de Melo Matos, Simone Castelo Branco Fortaleza, Felipe V C Machado, Rafael Mesquita","doi":"10.1080/02770903.2025.2562580","DOIUrl":"10.1080/02770903.2025.2562580","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the reliability, construct and content validity, ceiling and floor effects, acceptability, and feasibility of the Patient-Specific Functional Scale (PSFS) in individuals with asthma.</p><p><strong>Methods: </strong>This methodological study included individuals with asthma. Sociodemographic and clinical characteristics, lung function (forced expiratory volume in one second - FEV<sub>1</sub>), asthma control, and quality of life (Asthma Quality of Life Questionnaire - AQLQ) were assessed, in addition to the administration of the PSFS. Reliability, construct, and content validity, as well as ceiling/floor effects, were analyzed.</p><p><strong>Results: </strong>One hundred participants were evaluated (88% women, mean age 56 ± 14 years), the mean PSFS score was 4.1 ± 2.3. Regarding reliability, the intraclass correlation coefficient was 0.95 (95% confidence interval (CI): 0.88-0.97, <i>p</i> < .0001). The PSFS showed a fair correlation with the AQLQ activity limitation domain (<i>r</i> = 0.34, <i>p</i> = .001) and a weak correlation with FEV<sub>1</sub> (<i>r</i> = 0.16, <i>p</i> = .19). Lower scores were observed in participants with poorer asthma control (<i>p</i> = .03). Ninety-seven percent of the activities reported in the PSFS were classified under the Activity and Participation domain of the International Classification of Functioning, Disability, and Health (ICF). No ceiling or floor effects were detected.</p><p><strong>Conclusions: </strong>The PSFS demonstrated strong reliability, adequate validity, and no ceiling or floor effects, supporting its potential as a useful tool for assessing activity limitations in asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of psychological support and respiratory function training in alleviating anxiety and improving lung function in patients with bronchial asthma. 心理支持和呼吸功能训练在支气管哮喘患者焦虑缓解和肺功能改善中的作用。
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-20 DOI: 10.1080/02770903.2025.2562572
Xiaofang Lin, Caiping Tan
{"title":"The role of psychological support and respiratory function training in alleviating anxiety and improving lung function in patients with bronchial asthma.","authors":"Xiaofang Lin, Caiping Tan","doi":"10.1080/02770903.2025.2562572","DOIUrl":"10.1080/02770903.2025.2562572","url":null,"abstract":"<p><strong>Objective: </strong>Patients with bronchial asthma often experience anxiety in addition to decreased lung function.</p><p><strong>Method: </strong>This study retrospectively enrolled 204 diagnosed and hospitalized patients with bronchial asthma in our hospital, and randomly divided them into the observation group and the control group. Firstly, the differences in baseline data between two groups of patients were analyzed. Secondly, the differences in anxiety scores (GAD-7, HADS), Peak Expiratory Flow (PEF) levels, and nursing satisfaction between two groups of patients were analyzed at 1 week, 1 month, and 3 months after nursing intervention. Finally, the generalized estimation equation is applied to analyze the interaction between nursing intervention and time.</p><p><strong>Result: </strong>There were no significant differences between the observation group and the control group in most baseline indicators, such as age and gender. At 1 week, 1 month, and 3 months after intervention, the GAD-7 and HADS levels in the intervention group were significantly lower than those in the control group, while the PEF level and patient satisfaction were significantly higher than those in the control group. Over time, GAD-7 and HADS significantly decrease, while PEF and satisfaction (<i>p</i> < 0.001) significantly increase. The interaction showed that psychological support and respiratory function training significantly reduced anxiety levels at 1 and 3 months after intervention (GAD-7: <i>p</i> = 0.032; HADS: <i>p</i> = 0.002), significantly increased PEF levels at 1 week and 1 month after intervention (<i>p</i> < 0.001), and significantly improved satisfaction levels at 3 months after intervention (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Psychological support combined with respiratory function training can significantly reduce anxiety levels in patients with bronchial asthma and improve lung function.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postural balance and falls in older adults with asthma: a controlled cross-sectional study with follow-up. 老年哮喘患者的体位平衡和跌倒:一项随访的对照横断面研究。
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-16 DOI: 10.1080/02770903.2025.2558760
Bruhna Schwambach, Fabiano Francisco de Lima, Patrícia Puccetti Pires, Rosana Câmara Agondi, Regina Maria Carvalho-Pinto, Celso R F Carvalho
{"title":"Postural balance and falls in older adults with asthma: a controlled cross-sectional study with follow-up.","authors":"Bruhna Schwambach, Fabiano Francisco de Lima, Patrícia Puccetti Pires, Rosana Câmara Agondi, Regina Maria Carvalho-Pinto, Celso R F Carvalho","doi":"10.1080/02770903.2025.2558760","DOIUrl":"10.1080/02770903.2025.2558760","url":null,"abstract":"<p><strong>Background: </strong>Postural balance is impaired in adults with asthma; however, this remains poorly understood in older people with asthma.</p><p><strong>Objective: </strong>To assess postural balance and the incidence of falls in older individuals with moderate to severe asthma.</p><p><strong>Methods: </strong>A controlled cross-sectional study with follow-up included individuals aged 65-80 years (asthma group, AG; <i>n</i> = 26) and without asthma (control group, CG; <i>n</i> = 27). The control group was matched by sex, age, and body mass index (BMI). The evaluations included comorbidities, fear of falling, muscle strength, and postural balance in different conditions. Subsequently, individuals received a fall diary and were followed up for six months.</p><p><strong>Results: </strong>AG had more comorbidities, greater fear of falling, and consumed more medications (<i>p</i> < 0.005). AG also had worse postural balance assessed by the Mini-BESTest compared to the CG (23 [18.0-25.0] <i>vs.</i> 24 [21.00-26.00] score; <i>p</i> = 0.03). AG showed a greater CoP oscillation than CG at rest in natural base without foam (1.22 [0.78-1.94] <i>vs.</i> 0.88 [0.64-1.37] cm<sup>2</sup>; <i>p</i> = 0.04) and at semi-tandem, post-exertion with foam (3.56 [2.59-6.57] <i>vs.</i> 2.54 [1.94-3.42] cm<sup>2</sup>, <i>p</i> = 0.006). No between-group difference was observed in the predicted quadriceps and ankle dorsiflexor muscle strength (<i>p</i> > 0.05). Despite greater fear of falling and poorer balance, no group difference was observed in fall incidence over 6 months (8 <i>vs.</i> 10 falls), which may be partially explained by the follow-up period and the characteristics of the control group.</p><p><strong>Conclusion: </strong>Our findings partially support the study hypothesis. Older adults with asthma exhibit impaired balance and an increased fear of falling, but this does not necessarily translate into a higher incidence of falls.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors for Uncontrolled Asthma in a Pediatric Population with Severe Asthma: FRAMAG Study. 严重哮喘儿童人群中未控制哮喘的危险因素:FRAMAG研究
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-15 DOI: 10.1080/02770903.2025.2562583
Elida Duenas-Meza, Sarah Pulido-Fentanes, Monica Mendez-Moreno, Nadia Juliana Proaños-Jurado
{"title":"Risk Factors for Uncontrolled Asthma in a Pediatric Population with Severe Asthma: FRAMAG Study.","authors":"Elida Duenas-Meza, Sarah Pulido-Fentanes, Monica Mendez-Moreno, Nadia Juliana Proaños-Jurado","doi":"10.1080/02770903.2025.2562583","DOIUrl":"https://doi.org/10.1080/02770903.2025.2562583","url":null,"abstract":"<p><p>Severe asthma (SA) in children is associated with significant morbidity, increased healthcare utilization, and reduced quality of life. Despite appropriate treatment, achieving optimal asthma control remains challenging, particularly in pediatric populations. This study aimed to identify factors associated with poor asthma control in children with SA, focusing on clinical, functional, and caregiver-related variables. This retrospective cohort study included children aged 6-17 years with SA followed for up to three years in the Asmaire-Rexpira Program in Bogota, Colombia. Asthma control was defined using a comprehensive composite score integrating symptom questionnaires, exacerbation history, corticosteroid use, hospitalizations, and spirometry. Multivariable logistic regression was used to identify independent risk factors for uncontrolled asthma. Results: Of the 228 children included, 35.5% had uncontrolled asthma. Obstructive sleep apnea (OR: 2.16; 95% CI: 1.13-4.11; p = 0.019) and moderate to severe impairment in caregiver quality of life (OR: 12.35; 95% CI: 4.15-36.80; p < 0.001) were independently associated with uncontrolled asthma. Systemic corticosteroid use and hospitalization in the prior year were significantly more common in this group. Lung function was preserved in most children; however, those with uncontrolled asthma exhibited significantly greater bronchodilator reversibility (5.8% vs. 4.1%; p = 0.015) and higher functional variability over time based on conditional FEV<sub>1</sub> change scores (≥ +1.96 z-score in 18.9% vs. 8.5%). Conclusions: uncontrolled asthma in children with SA is associated with comorbid sleep apnea, caregiver burden, and functional variability despite normal spirometric values. These findings underscore the need for multidimensional evaluation, caregiver support, and longitudinal monitoring to optimize asthma control in high-risk pediatric populations.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Point application therapy targeting Feishu, Pishu and Shenshu attenuates asthma by suppressing autophagy and the AMPK-mTOR signalling pathway. 穴位贴敷治疗肺俞、脾俞、肾俞通过抑制自噬和AMPK-mTOR信号通路减轻哮喘。
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-15 DOI: 10.1080/02770903.2025.2558759
Yutong Jin, Yena Gu, Lihua Xuan
{"title":"Point application therapy targeting Feishu, Pishu and Shenshu attenuates asthma by suppressing autophagy and the AMPK-mTOR signalling pathway.","authors":"Yutong Jin, Yena Gu, Lihua Xuan","doi":"10.1080/02770903.2025.2558759","DOIUrl":"10.1080/02770903.2025.2558759","url":null,"abstract":"<p><strong>Objective: </strong>In traditional Chinese medicine, asthma is associated with deficiencies in Lung Qi, Spleen Qi, and Kidney Qi. This study investigated the therapeutic mechanism of point application therapy focusing on the acupoints Feishu (BL13), Pishu (BL20), and Shenshu (BL23) for asthma treatment.</p><p><strong>Methods: </strong>An asthma model was established in Wistar rats <i>via</i> intraperitoneal ovalbumin injection combined with nebulization. Therapeutic ointments were prepared using white mustard seed, Yanhusuo, Gansui and Asarum sieboldii, which were applied topically to the Feishu (BL13), Pishu (BL20) and Shenshu (BL23) acupoints. To examine the mechanistic basis, the AMPK inhibitor dorsomorphin (compound C, CC) was employed. We subsequently measured inflammatory factor levels in rat serum and bronchoalveolar lavage fluid, quantified AMPK/mTOR pathway-related protein expression, and assessed pulmonary inflammation alongside collagen deposition in airway mucosa.</p><p><strong>Results: </strong>The point application therapy significantly ameliorated asthma symptoms and reduced levels of inflammatory factors, including interleukin (IL)-6 and IL-1<i>β</i>, in both serum and bronchoalveolar lavage fluid. The treatment additionally decreased expression levels of mTOR, LC3, NF-κB and TGF-<i>β</i>1 while increasing AMPK content. Histological examination revealed reduced inflammatory cell infiltration and diminished collagen deposition in both lung and airway tissues. Crucially, administration of the AMPK inhibitor dorsomorphin substantially attenuated the therapeutic efficacy of point application therapy in asthmatic rats.</p><p><strong>Conclusions: </strong>Point application therapy targeting Feishu, Pishu and Shenshu acupoints inhibits autophagy in airway and lung tissues in asthma. These therapeutic effects are mediated, at least partially, through the AMPK/mTOR pathway.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The breath of revolution: Illness and metaphor in the life of Ernesto "Che" Guevara. 革命的气息:切·格瓦拉一生中的疾病与隐喻。
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-12 DOI: 10.1080/02770903.2025.2555309
Domenico Ribatti, Francesco M Galassi, Elena Varotto, Mauro Vaccarezza
{"title":"The breath of revolution: Illness and metaphor in the life of Ernesto \"Che\" Guevara.","authors":"Domenico Ribatti, Francesco M Galassi, Elena Varotto, Mauro Vaccarezza","doi":"10.1080/02770903.2025.2555309","DOIUrl":"10.1080/02770903.2025.2555309","url":null,"abstract":"<p><p>This article examines the chronic asthma of Ernesto \"Che\" Guevara not merely as a biomedical condition, but as a metaphorical and existential element of his revolutionary identity. Drawing on Aristotle's theory of metaphor and S. Sontag's cultural critique of illness, it explores how Guevara's lifelong struggle with asthma shaped his medical vocation and informed his political radicalism. Through a close reading of primary sources-including Guevara's letters, diaries, and biographical accounts-this study contextualizes his disease as both a personal crucible and a symbol of rebellion. The article situates Guevara within a lineage of physician-activists, alongside Albert Schweitzer and Frantz Fanon, to consider the transformative potential of embodied suffering in revolutionary praxis.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-3"},"PeriodicalIF":1.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating inflammatory proteins as causal drivers and therapeutic targets in asthma: insights from genetic and pathway-based analyses. 循环炎症蛋白作为哮喘的病因驱动因素和治疗靶点:来自遗传和通路分析的见解。
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-08 DOI: 10.1080/02770903.2025.2555292
Yiyan Miao, Haihua Chen, Qishu Wei, Kun Yan, Praise Audax Rukonge, Zhe Zhang, Guiping Yu
{"title":"Circulating inflammatory proteins as causal drivers and therapeutic targets in asthma: insights from genetic and pathway-based analyses.","authors":"Yiyan Miao, Haihua Chen, Qishu Wei, Kun Yan, Praise Audax Rukonge, Zhe Zhang, Guiping Yu","doi":"10.1080/02770903.2025.2555292","DOIUrl":"10.1080/02770903.2025.2555292","url":null,"abstract":"<p><strong>Objective: </strong>To identify circulating inflammatory proteins with potential causal roles in asthma development through integrated genetic and pathway-based analyses, and to evaluate their potential as therapeutic targets.</p><p><strong>Methods: </strong>We used genetically anchored instrumental variables from 180 protein quantitative trait loci (pQTLs) to assess the causal effects of 91 circulating inflammatory proteins on asthma risk, using large-scale GWAS datasets. Analytical robustness was evaluated through pleiotropy and heterogeneity testing. Functional enrichment and literature-based pathway analyses were performed to support biological plausibility and validate findings.</p><p><strong>Results: </strong>Four proteins showed significant causal effects on asthma: CCL19 and LIFR were protective (OR = 0.89 and 0.91, <i>p</i> ≤ 6.8E-03), while ARTN and IL6 were associated with increased risk (OR = 1.15 and 1.18, <i>p</i> ≤ 1.1E-04). We also identified reverse causal effects of asthma on 11 cytokines, including MMP10, TGFB1, IL33, and IL18R1. Most of these proteins were enriched in pathways related to cytokine signaling and immune response (<i>p</i> < 0.001). All identified proteins had prior literature support linking them to asthma or airway inflammation.</p><p><strong>Conclusions: </strong>Our findings highlight a subset of circulating inflammatory proteins that are likely causal in asthma pathogenesis and may serve as promising targets for therapeutic intervention. These results offer novel insights into the immunological mechanisms underlying asthma and support the utility of genetic causal inference in target prioritization.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary antioxidants: a challenge or an opportunity for asthma? Genetic insights from a Two-sample mendelian randomization study. 饮食抗氧化剂:哮喘的挑战还是机遇?来自两样本孟德尔随机化研究的遗传学见解。
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-08 DOI: 10.1080/02770903.2025.2555297
Xiaoqing Zhou, Yujie Zhou, Jialing Chen, Chen Chen, Ruilin Chen, Suqun Zheng, Zhen Wang, Linshui Zhou
{"title":"Dietary antioxidants: a challenge or an opportunity for asthma? Genetic insights from a Two-sample mendelian randomization study.","authors":"Xiaoqing Zhou, Yujie Zhou, Jialing Chen, Chen Chen, Ruilin Chen, Suqun Zheng, Zhen Wang, Linshui Zhou","doi":"10.1080/02770903.2025.2555297","DOIUrl":"10.1080/02770903.2025.2555297","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress is crucial in the immune response and airway inflammatory process associated with asthma. While the relationship between dietary antioxidants and asthma remains debated in observational studies, this study uses two-sample Mendelian randomization (MR) to explore a potential causal link.</p><p><strong>Methods: </strong>We acquired six distinct categories of absolute circulating antioxidants and five different types of metabolic circulating antioxidants from the most recent genome-wide association study data of the European population, including vitamin A (retinol), vitamin C (ascorbic acid), vitamin E (tocopherol), β-carotene, lycopene, and urate. The latest data regarding asthma was obtained from the FinnGen database. We utilized single nucleotide polymorphisms as instrumental variables to conduct five MR methods. To confirm the accuracy of the results, additional sensitivity analyses were performed to eliminate any potential confounding factors, such as heterogeneity and pleiotropy.</p><p><strong>Results: </strong>MR and sensitivity analyses revealed an association between circulating urate and asthma, suggesting a potential increase in asthma risk (OR = 1.090; 95% CI = 1.030-1.150; <i>p</i> = 0.004). No causal relationship was found for other antioxidants.</p><p><strong>Conclusions: </strong>This MR analysis suggested that genetically determined circulating urate may increase asthma risk. Further large-scale randomized controlled trials and mediated MR analysis are needed to explore underlying mechanisms.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical activity levels in individuals with asthma: a comparison between wearable device users and non-users: 2017 BRFSS. 哮喘患者的身体活动水平:可穿戴设备用户和非用户之间的比较:2017 BRFSS。
IF 1.3 4区 医学
Journal of Asthma Pub Date : 2025-09-08 DOI: 10.1080/02770903.2025.2555301
Willie Leung, Maleiah Hubbard, Jinhyun Lee, Moosong Kim, Lu Shi
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