Journal of Asthma最新文献

{"title":"Patterns and trends in burden of asthma and its attributable risk factors from 1990 to 2021 among South Asian countries: a systematic analysis for the Global Burden of Disease Study 2021.","authors":"Akashanand, Mahalaqua Nazli Khatib, Ashok Kumar Balaraman, R Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G V Siva Prasad, Pranchal Rajput, Teena Vishwakarma, Sonam Puri, Puneet Tyagi, Ganesh Bushi, Nagavalli Chilakam, Sakshi Pandey, Megha Jagga, Rachana Mehta, Sanjit Sah, Muhammed Shabil, Abhay M Gaidhane, Diptismita Jena","doi":"10.1080/02770903.2025.2453810","DOIUrl":"10.1080/02770903.2025.2453810","url":null,"abstract":"<p><strong>Objective: </strong>Asthma poses a significant health burden in South Asia, with increasing incidence and mortality despite a global decline in age-standardized prevalence rates. This study aims to analyze asthma trends from 1990 to 2021, focusing on prevalence, incidence, mortality, and disability-adjusted life years (DALYs) across South Asia. The study also assesses the impact of risk factors like high body mass index (BMI), smoking, and occupational exposures on asthma outcomes.</p><p><strong>Method: </strong>We extracted asthma data from the Global Burden of Disease database for South Asia (1990-2021). Joinpoint regression analysis was used to assess temporal trends in asthma burden. Total Percentage change (TPC) in age-standardized rates of incidence, mortality, and DALYs were calculated. Data were stratified by gender, and the contribution of risk factors was evaluated.</p><p><strong>Results: </strong>Asthma-related mortality in South Asia decreased by 37%, from 27.78 per 100,000 (1990) to 17.54 per 100,000 (2021). The Maldives showed the most significant reduction in mortality (78.31%), while Bangladesh recorded a 47.44% reduction in prevalence and a 62.64% decrease in DALYs. High BMI, smoking, and environmental risks contributed significantly to DALYs, with environmental factors playing a major role in countries like Afghanistan (20.73%) and Bhutan (18.58%). Females, particularly those over 20, experienced higher asthma-related DALYs than males.</p><p><strong>Conclusion: </strong>Asthma burden in South Asia has reduced over the past three decades, yet the absolute number of cases continues to rise, driven by population growth and environmental risk factors. Targeted interventions addressing risk factors and healthcare disparities are essential for further reducing asthma burden.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1020-1031"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and regional mortality trends in patients with asthma in the United States (1999-2020): a CDC WONDER analysis.","authors":"Sophia Ahmed, Muhammad Asfandyar Nadir, Areej Iftikhar, Hamza Ashraf, Mohammad Ashraf","doi":"10.1080/02770903.2025.2458519","DOIUrl":"10.1080/02770903.2025.2458519","url":null,"abstract":"<p><strong>Objective: </strong>Around 7.7% of Americans have asthma, including 20.2 million adults and 4.6 million children. This study examines asthma mortality trends and disparities across U.S. demographic and geographic groups from 1999 to 2020.</p><p><strong>Methods: </strong>A retrospective analysis was conducted using the CDC WONDER database to examine asthma-related deaths in the U.S. from 1999 to 2020. Age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) per 100,000 were calculated. Trends and annual percent changes (APCs) were assessed overall and stratified by sex, race, region, and age.</p><p><strong>Results: </strong>From 1999 to 2020, the U.S. recorded 221 161 asthma-related deaths (AAMR: 3.07), mostly in medical facilities. Mortality declined from 1999 to 2018 (APC: -1.53%) but surged from 2018 to 2020 (APC: 28.63%). Females, NH Blacks, and NH American Indians had the highest mortality rates. Older adults (≥65) had the greatest burden, with younger groups showing notable increases post-2018. Rural areas and the West reported slightly higher rates than urban and other regions. Hawaii and the District of Columbia had the highest AAMRs, while Florida and Nevada had the lowest.</p><p><strong>Conclusion: </strong>Asthma-related mortality in the U.S. declined until 2018 but sharply increased from 2018 to 2020, with rises across all demographic groups, regions, and settings. Females, NH Blacks, and older adults consistently had higher mortality rates, while younger age groups showed recent alarming increases. Targeted interventions are urgently needed to address inequities and recent mortality surges.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1070-1081"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Asthma Exacerbations in Pediatric Emergency Departments Across the United States.","authors":"Melisa S Tanverdi, Isabella Zaniletti, Nidhya Navanandan, Isabel Hardee, Andrew H Liu, Rakesh D Mistry","doi":"10.1080/02770903.2025.2513056","DOIUrl":"https://doi.org/10.1080/02770903.2025.2513056","url":null,"abstract":"<p><strong>Objectives: </strong>There are 750,000 emergency department (ED) visits by children for asthma exacerbations in the United States annually. Despite changing evidence and epidemiology, there have not been recent assessments of acute asthma prevalence, management, and outcomes from pediatric EDs. This 40-center retrospective evaluation utilizes the Pediatric Hospital Information System to characterize pediatric ED asthma presentations from 2015-2020.</p><p><strong>Study design: </strong>Children 2-18 years with asthma ICD-9/10 code and receipt of albuterol were included. Demographics, Child Opportunity Index (COI), ED management, return visits, and adjusted costs were evaluated. Data were summarized using standard descriptive statistics and trends assessed using Mann-Kendall trend test.</p><p><strong>Results: </strong>There were 414,264 encounters made by 256,209 unique patients; 21% had >1 visit in 12 months. Median age was 6 years, 61.6% male, 44.5% Black, and 68.5% publicly insured; 58.3% of visits were by patients with very low/low COI. Systemic corticosteroids were administered in 86.3% of visits; 52.7% used dexamethasone. Chest radiographs were obtained in 23% of encounters. Most (74.9%) encounters resulted in ED discharge with a downward trend of visits for exacerbations per 1,000 ED visits of -9.77, 95% CI [-9.99,-9.54], increase in disposition to intensive care unit of 2.01 [1.87,2.41] and decrease in home/other of -3.77 [-4.34,-3.20]. There was no significant trend in return visits. Total adjusted costs were ∼$900 million.</p><p><strong>Conclusions: </strong>ED visits for asthma remain frequent and disproportionately affect children with lower social determinants of health. Dexamethasone has not been widely adopted as corticosteroid of choice and use of ancillary testing continues, highlighting opportunities for improvement in asthma care.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ERS/ATS 2022 bronchodilator response guidelines in asthma control.","authors":"Clara Seghers Carreras, Miguel Jiménez Gómez, Begoña Peña Del Cura, Lucía Ortega Ruíz, Fernando Vargas Ursúa, Cristina Martín-Arriscado Arroba, Carlos Melero Moreno, Rocío Magdalena Díaz Campos","doi":"10.1080/02770903.2025.2513060","DOIUrl":"https://doi.org/10.1080/02770903.2025.2513060","url":null,"abstract":"<p><p>The aim of this study was to determine whether the BDR according to the new cut-off values is associated with worse asthma control compared with the 2005 definition.We conducted a prospective study on moderate to severe asthma patients under clinical follow-up. Patients were classified based on the BDR using both ERS/ATS 2022 and 2005 thresholds. We collected clinical and functional data, along with exacerbations over a one-year follow-up period.Among the 198 patients included, mean age was 60.2 years-old (SD 16.3), with 74.7% being women and 69.7% having severe asthma. According to the 2005 threshold, 46 (23.2%) showed bronchodilator responsiveness, whereas with the 2022 recommendations decreased to 38 (19.2%). The agreement between the 2005 and 2022 ERS/ATS criteria for BDR positivity was 92.17%, with a Cohen's kappa coefficient of 0.76 (p < 0.001). Using the 2022 cut-off values, patients with BDR had a significantly lower mean asthma control test (ACT) score (19.9 vs 22.5; p = 0.001), while no difference was observed with the 2005 criteria. The relative risk of exacerbations after 1 year follow-up was 1.23 (CI 95% 1-1.25) with the 2022 recommendations, compared to 1.09 (CI 95% 0.88- 1.38) with the 2005 criteria.The use of the new BDR criteria could provide a valuable marker of asthma control, allowing for better risk stratification and more informed therapeutic decisions.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the 2020 Healthy Eating Index with Asthma in Children and Adolescents in the United States: A Cross-Sectional Study of NHANES.","authors":"Tong Lu, Qiang Yu, Liyong Che, Xiaolan Zhang, Chao Che, Linjun Du, Jia Jia","doi":"10.1080/02770903.2025.2512596","DOIUrl":"https://doi.org/10.1080/02770903.2025.2512596","url":null,"abstract":"<p><strong>Objective: </strong>Our goal was to investigate the connection between asthma and HEI-2020.</p><p><strong>Data sources: </strong>A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2020.</p><p><strong>Study selections: </strong>Diet quality was measured as HEI-2020 scores using 24-hour and 2-day dietary recall data. A range of statistical methods, including as sensitivity analysis, restricted triple spline analysis, subgroup analysis, and multivariate logistic regression, were used to assess the relationship between the HEI-2020 and asthma.</p><p><strong>Results: </strong>2,740 (17.5%) of the 15,667 said a doctor or other health care provider had diagnosed them with asthma. The lower a child or adolescent's risk of developing asthma, after adjusting for pertinent factors, the higher the overall HEI-2020 score. The adjusted odds ratios (OR) for asthma in the second (Tertiles 2, 42.92-<51.9) and third (Tertiles 3, 42.92-51.9) groups were 0.93 (0.84-1.03) and 0.83 (0.73-0.94), respectively, in comparison to the group with the lowest HEI-2020 values (Tertiles 1, 18.35-<42.92). The results' resilience was further validated using stratified and sensitivity analyses. Asthma risk may also be decreased by eating less sodium and added sweets and more total fruits, whole fruits, seafood and plant proteins.</p><p><strong>Conclusion: </strong>There is a negative correlation between asthma and the Healthy Eating Index-2020 in children and adolescents in the United States.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dilemma of the asthmatic patient: fight with the help of drugs or escape to a healthier environment?","authors":"Giovanni Rolla","doi":"10.1080/02770903.2025.2513593","DOIUrl":"https://doi.org/10.1080/02770903.2025.2513593","url":null,"abstract":"<p><p>Asthma is characterized by chronic airway inflammation that underlies exacerbations in response to environmental triggers. The notable change in the environment that has occurred in recent decades, both outdoor and indoor, has contributed to increasing the concentrations of substances considered toxic to epithelia, including the epithelium of the airways.Considering the importance of environmental triggers, an avoidance strategy for environmental triggers could be useful for improving asthma control with sparing use of medications. <b>The purpose of my commentary is to provide evidence that avoidance of environmental triggers can help control asthma with a consequent saving of anti-asthma medications</b>. This approach requires that monitoring of pollutants to which the patient is exposed becomes part of the patient evaluation as is the search for biomarkers of inflammatory response. Many observations have shown that reduced exposure to NOx, household cleaning products and fine particulate matter is able to improve asthma control. Equally important for the control of asthma were the remediation of houses with damp and mold. Greater consideration of the environmental triggers of asthma exacerbations can help the clinician further personalize the asthma treatment strategy. My message is to combine the immunophenotyping of asthma (<b>T2 high vs T2 low</b>) with a sort of phenotyping of environmental triggers.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-inhaler triple therapy improves small airway dysfunction in moderate to severe asthma and asthma-COPD overlap: a retrospective cohort study.","authors":"Yumi Fujita, Toshihiro Shirai, Taisuke Akamatsu, Shogo Sakurai","doi":"10.1080/02770903.2025.2513053","DOIUrl":"https://doi.org/10.1080/02770903.2025.2513053","url":null,"abstract":"<p><strong>Background: </strong>Medium- or high-dose fluticasone furoate (FF)/vilanterol (VI)/umeclidinium (UMEC) is associated with an improvement in forced expiratory volume in one second (FEV1), a marker of large airway dysfunction. However, the effect of FF/VI/UMEC on small airway dysfunction (SAD) remains unknown.</p><p><strong>Objective: </strong>To clarify the effect of FF/VI/UMEC on SAD in moderate to severe asthma and asthma-chronic obstructive pulmonary disease overlap (ACO) in a retrospective cohort study.</p><p><strong>Methods: </strong>Subjects included 18 moderate to severe asthma and ACO patients who switched from inhaled corticosteroid/long-acting-β2 agonist (ICS/LABA) to FF/VI/UMEC. Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), blood eosinophil counts, total IgE, fractional exhaled nitric oxide, spirometry, and oscillometry were measured and compared before and after FF/VI/UMEC treatment.</p><p><strong>Results: </strong>Markers of SAD, including forced vital capacity (FVC), forced expiratory flow at 25-75% of FVC, respiratory system reactance at 5Hz (X5), resonant frequency, and low-frequency reactance area (AX), improved significantly after the induction of SITT, in addition to ACT, ACQ, FEV1, and FEV1/FVC. Improvements in FEV1, X5, and AX correlated with improvements in ACT, and improvements in FEV1 and FEV1/FVC correlated with improvements in ACQ.</p><p><strong>Conclusion: </strong>FF/VI/UMEC improved SAD, and its improvement was correlated with improved asthma control in moderate to severe asthma and ACO patients.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-driven airway eosinophilia and neutrophilia in asthma.","authors":"Joseph Zouein, Loretta G Que, Jennifer L Ingram","doi":"10.1080/02770903.2025.2505464","DOIUrl":"10.1080/02770903.2025.2505464","url":null,"abstract":"<p><strong>Objective: </strong>Asthma patients with comorbid obesity tend to have more severe, difficult-to-control asthma than lean asthma patients. This increase in asthma severity may be due, in part, to obesity-related adipokines, such as leptin, which contribute to airway hyperresponsiveness, sustained subclinical chronic inflammation, and treatment resistance. This narrative literature review aims to elucidate the differences in airway eosinophilia and neutrophilia profiles between asthma patients with and without obesity.</p><p><strong>Methods: </strong>A PubMed search of full journal articles published between 1992 and 2024 was performed in April 2024 using the terms \"asthma\", \"tissue eosinophilia\" and \"obesity\" combined with the Boolean operator \"AND\". Articles detailing airway tissue eosinophilia and neutrophilia in asthma patients or mice were included. Only articles in English were included.</p><p><strong>Results: </strong>To date, several studies have reported increased airway tissue eosinophilia in obese mouse asthma models (four studies) and in asthma patients with obesity (three studies). Airway tissue eosinophilia in asthma patients with obesity is driven by altered and elevated levels of adipokines, pro-inflammatory cytokines, and eosinophil-stimulating chemokines such as eotaxin. Leptin and eotaxin levels are increased in asthma with obesity and contribute to enhanced eosinophil recruitment, migration, adhesion to airway smooth muscles and fibroblasts, and reduced apoptosis.</p><p><strong>Conclusions: </strong>Airway tissue eosinophilia is an important feature of obesity-associated asthma. Airway tissue eosinophilia is mainly driven by obesity-related homeostatic changes. These increased airway tissue eosinophils contribute to a more severe disease.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the nutraceutical and nutritional features of wheat germ to reduce atopic asthma symptoms in children.","authors":"Fahri Bayiroglu, Nilgun Erdonmez, Leyla Aydin, Mehmet Salih Kaya","doi":"10.1080/02770903.2025.2499833","DOIUrl":"https://doi.org/10.1080/02770903.2025.2499833","url":null,"abstract":"<p><strong>Background: </strong>The rise in childhood asthma has increased interest in nutraceutical treatment options such as specific nutritional supplements, as medical treatments may not always produce the desired results. Despite treatment, between 30 and 50% of children with asthma do not attain adequate control.</p><p><strong>Objectives: </strong>For the first time, the effects of adding fermented wheat germ to the daily diet of children with atopic asthma on respiratory function-related disease symptoms, serum IgE, and eosinophil levels were studied.</p><p><strong>Methods: </strong>The study comprised 52 patients (control group <i>n</i> = 26, experimental group <i>n</i> = 26) aged 12-18 years with a clear diagnosis of atopic asthma. The experimental group consumed 100 g of fermented wheat bread with 5% wheat germ every day for three months, while the control group consumed standard bread. The groups were assessed at baseline and at the end of each month with spirometry (FVC, FEV1, PEF), serum eosinophil and IgE measurements, and the application of the Asthma Control Test (ACT) scale.</p><p><strong>Results: </strong>There was no significant difference between the control and experimental groups in terms of any measurement. The experimental group had significant increases in PEF (<i>p</i> < 0.05), FVC, and IgE levels (<i>p</i> < 0.001) compared to monthly measurements. Both groups showed statistically significant improvements in ACT and FEV1 (<i>p</i> < 0.001). Nonetheless, the control and experimental groups showed no significant difference in time-dependent eosinophil levels (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>Although the inclusion of fermented wheat germ to asthmatic children's diets has been shown to improve PEF and IgE levels, these findings require further investigation.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct characteristics of asthma overlap phenotypes: Insights from the Turkish adult asthma registry.","authors":"Secil Kepil Ozdemir, Bilun Gemicioglu, Fusun Yildiz, Serhat Hayme, Gulistan Alpagat, Nurgul Bozkurt, Ismet Bulut, Munevver Erdinc, Gul Karakaya, Metin Keren, Gulden Pacaci Cetin, Insu Yilmaz, Arzu Yorgancioglu, Omur Aydin, Derya Gokmen, Gozde Koycu Buhari, Zeynep Celebi Sozener, Sengul Beyaz, Cihan Orcen, Ebru Damadoglu, Tugce Yakut, Ayse Fusun Kalpaklioglu, Ayse Baccioglu, Sumeyra Alan Yalim, Ilkay Koca Kalkan, Mehmet Atilla Uysal, Elif Yelda Ozgun Niksarlioglu, Ali Fuat Kalyoncu, Muge Erbay, Sibel Nayci, Fatma Merve Tepetam, Aslı Gelincik, Hulya Dirol, Ozlem Goksel, Selen Karaoglanoglu, Ferda Oner Erkekol, Sacide Rana Isik, Yasemin Yavuz, Dilek Karadogan, Ummuhan Seker, Ipek Kivilcim Oguzulgen, Ilknur Basyigit, Serap Argun Baris, Elif Yilmazel Ucar, Tuba Erdogan, Mehmet Polatli, Dane Ediger, Fatma Esra Gunaydin, Murat Turk, Leyla Pur, Zeynep Yegin Katran, Yonca Sekibag, Enes Furkan Aykac, Dilsad Mungan, Ozcan Gul, Ali Cengiz, Bulent Akkurt, Seyma Ozden, Semra Demir, Derya Unal, Ayse Feyza Aslan, Ali Can, Reyhan Gumusburun, Gulhan Bogatekin, Hatice Serpil Akten, Sinem Inan, Aliye Candan Ogus, Murat Kavas, Demet Polat Yulug, Mehmet Erdem Cakmak, Saltuk Bugra Kaya, Eylem Sercan Ozgur, Oguz Uzun, Sule Tas Gulen, Gulseren Pekbak, Deniz Kizilirmak, Yavuz Havlucu, Halil Donmez, Bahar Arslan, Sadan Soyyigit, Bilge Yilmaz Kara, Gulden Pasaoglu Karakis, Adile Berna Dursun, Resat Kendirlinan, Ayse Bilge Ozturk, Can Sevinc, Gokcen Omeroglu Simsek, Oznur Abadoglu, Pamir Cerci, Taskin Yucel, Irfan Yorulmaz, Zahide Ciler Tezcaner, Emel Cadalli Tatar, Ahmet Emre Suslu, Serdar Ozer, Engin Dursun, Gulfem Elif Celik","doi":"10.1080/02770903.2025.2493134","DOIUrl":"10.1080/02770903.2025.2493134","url":null,"abstract":"<p><strong>Introduction: </strong>Considerable overlaps exist between asthma phenotypes and the clinical significance of these overlaps remains undetermined. The objective of this study is to analyze the characteristics of asthma overlap phenotypes using data from the Turkish Adult Asthma Registry (TAAR).</p><p><strong>Methods: </strong>This cross-sectional registry study included 2053 adult patients (74.8% female) with asthma.</p><p><strong>Results: </strong>Overall, 39.3% (<i>n</i> = 697) had allergic-eosinophilic (AE), 26.0% (<i>n</i> = 461) had allergic-non-eosinophilic (ANE), 21.3% (<i>n</i> = 377) had non-allergic-eosinophilic (NAE), and 13.4% (<i>n</i> = 237) had non-allergic-non-eosinophilic (NANE) asthma. Severe asthma exacerbations and emergency department (ED) visits were more frequent in the AE (28.3%, 31.2%, respectively) and NAE groups (36.0%, 34.0%, respectively) than in the ANE (14.3%, 20.6%, respectively) and NANE groups (12.6%, 16.7%, respectively) (<i>p</i> < 0.001). FEV1 values were significantly lower in the AE group than in the ANE and NANE groups (<i>p</i> < 0.001, <i>p</i> = 0.048, respectively) and in the NAE group than in the ANE group (<i>p</i> < 0.001). Risk factors for poor asthma control included living in rural areas, asthma-related ED visits, FEV1 < 60% in the NAE; being overweight, chronic rhinosinusitis, oral corticosteroids use, age < 40 years in the NANE; FEV1 < 80% in the AE; and severe asthma exacerbations, ED visits for AE and ANE groups.</p><p><strong>Conclusion: </strong>The considerable overlap between allergic and eosinophilic asthma phenotypes has clinical implications as increased rates of asthma exacerbations and healthcare utilization. The clinical heterogeneity among asthma phenotypes based on a single biomarker highlights the importance of multidimensional asthma phenotyping.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}