Journal of Asthma最新文献

Evaluation of sexual problems in asthmatic patients. 哮喘患者性问题的评价。

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-08 DOI: 10.1080/02770903.2026.2666085

Suayip Ceylan, Ahmet Cagın, Onur Ozturk

{"title":"Evaluation of sexual problems in asthmatic patients.","authors":"Suayip Ceylan, Ahmet Cagın, Onur Ozturk","doi":"10.1080/02770903.2026.2666085","DOIUrl":"10.1080/02770903.2026.2666085","url":null,"abstract":"Objective: This study evaluated sexual function in patients with asthma and its association with sociodemographic and clinical factors.Methods: This cross-sectional study included 380 individuals (aged 18-49) diagnosed with asthma for at least six months and was conducted at the pulmonology outpatient clinic of Samsun University Training and Research Hospital. Data were collected using a structured sociodemographic and sexual repertoire form and the Golombok-Rust Inventory of Sexual Satisfaction (GRISS). Statistical analyses included Chi-square, Mann-Whitney's U, and independent samples t-tests, followed by multivariable linear regression to identify independent predictors of sexual dysfunction.Results: A total of 380 individuals participated in the study, with an equal number of male and female participants. Females had significantly higher total GRISS scores than males (p = 0.001). Married individuals reported higher sexual satisfaction than singles (p = 0.004) in univariate analysis; however, marital status was not an independent factor in multivariable regression analysis. GRISS scores decreased with increasing education level (p = 0.008). Married participants reported a significant reduction in vaginal intercourse (p = 0.019). Additionally, participants who experienced fear of an asthma attack during intercourse had significantly higher scores than those who did not (p = 0.003).Conclusions: Women, single individuals, and those with lower educational levels reported higher GRISS scores, indicating more sexual dysfunction. Similarly, high scores were observed among participants who experienced fear of an asthma attack during intercourse. These findings suggest that asthma appears to be associated with multidimensional impairments in sexual health.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors, preventive strategies, and long-term effects of lower respiratory tract infections in early childhood: a comprehensive review. 儿童早期下呼吸道感染的危险因素、预防策略和长期影响：一项综合综述。

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-08 DOI: 10.1080/02770903.2026.2666102

Arul Kiruba N M, Mary Minolin T, Mary Nithya P

{"title":"Risk factors, preventive strategies, and long-term effects of lower respiratory tract infections in early childhood: a comprehensive review.","authors":"Arul Kiruba N M, Mary Minolin T, Mary Nithya P","doi":"10.1080/02770903.2026.2666102","DOIUrl":"10.1080/02770903.2026.2666102","url":null,"abstract":"Objective: To synthesize existing evidence on the risk factors, preventive measures, and long-term outcomes of lower respiratory tract infections (LRTIs) in early childhood, and to identify key gaps in research and policy.Methods: A systematic search was conducted in PubMed, Scopus, and Web of Science for studies published between January 2000 and August 2025, supplemented by reports from WHO, UNICEF, and the Global Burden of Disease (GBD) database. Eligible studies included randomized controlled trials, cohort, case-control, and cross-sectional studies, as well as systematic reviews involving children aged 0-5 years. Studies focused solely on acute treatment or adult populations were excluded.Results: Early-life LRTIs arise from interacting determinants, including prematurity, malnutrition, indoor air pollution, inadequate immunization, and socioeconomic inequities. Preventive strategies such as vaccination, maternal immunization, exclusive breastfeeding, micronutrient supplementation, and the use of clean fuels-significantly reduce childhood morbidity and mortality. Evidence also indicates long-term health consequences, including asthma, impaired lung function, neurodevelopmental delay, and increased cardiometabolic risk.Conclusions: Early-life LRTIs represent both an acute health burden and a determinant of lifelong respiratory and systemic outcomes. Expanding equitable vaccination coverage, improving maternal and child nutrition, reducing environmental exposures, and strengthening health-system capacity are essential to mitigate both short- and long-term global impacts.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between nocturnal asthma, symptom severity, and clinical outcomes: a systematic review. 夜间哮喘、症状严重程度与临床结果的关系：一项系统综述。

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-07 DOI: 10.1080/02770903.2026.2660319

Patricia Tachinardi, Gustavo Yano Callado, Julia M G Ferreira, Maria Celidonio Gutfreund, Isabele Pardo, Edson C D Lopes, Lucas Bulgarelli, Colin M Rogerson, Rodrigo Octavio Deliberato, Alexandre R Marra, Eneida A Mendonça

{"title":"Association between nocturnal asthma, symptom severity, and clinical outcomes: a systematic review.","authors":"Patricia Tachinardi, Gustavo Yano Callado, Julia M G Ferreira, Maria Celidonio Gutfreund, Isabele Pardo, Edson C D Lopes, Lucas Bulgarelli, Colin M Rogerson, Rodrigo Octavio Deliberato, Alexandre R Marra, Eneida A Mendonça","doi":"10.1080/02770903.2026.2660319","DOIUrl":"10.1080/02770903.2026.2660319","url":null,"abstract":"Objective: Nocturnal asthma is characterized by the worsening of asthma symptoms during the night and indicates more severe disease. This review aims to analyze evidence regarding the association between nocturnal asthma, symptom severity, pulmonary function, and clinical outcomes in both adult and pediatric populations.Methods: Databases Embase, PubMed, CINAHL, Cochrane (Wiley), Scopus, and LILACS were searched from their dates of inception to April 8, 2024. We included studies comparing severity of asthma symptoms, pulmonary function, and clinical outcomes in patients with nocturnal asthma to patients with nocturnal asthma.Results: Thirteen studies met the inclusion criteria for this review. These studies varied in setting, population, definitions of nocturnal, and outcome assessment. Despite methodological heterogeneity, a consistent pattern emerged: none of the evaluated outcomes had better results in the nocturnal asthma group, and nocturnal asthma was associated with worse symptom severity and poorer pulmonary function in most studies. However, evidence regarding hospital outcomes was mixed, with only one study reporting increased ward or intensive care unit (ICU) admission rates for nocturnal asthma patients, and no differences observed in length of stay.Conclusions: Evidence presented in this systematic review reinforced the association between nocturnal asthma and more severe disease manifestations, including worse symptom scores and poorer pulmonary function compared to non-nocturnal asthma. While evidence regarding hospitalization outcomes remains inconclusive, the findings underscore the clinical significance of recognizing nocturnal symptoms to improve disease management and diagnosis.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the association between omalizumab use and adverse fetal outcomes among pregnant women with asthma: a population-based retrospective cohort study. 评估哮喘孕妇使用omalizumab与不良胎儿结局之间的关系：一项基于人群的回顾性队列研究

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-05 DOI: 10.1080/02770903.2026.2666093

Chun-Tse Hung, Ting-An Yen, Hsin-Yi Huang, Chung-Hsuen Wu

{"title":"Evaluating the association between omalizumab use and adverse fetal outcomes among pregnant women with asthma: a population-based retrospective cohort study.","authors":"Chun-Tse Hung, Ting-An Yen, Hsin-Yi Huang, Chung-Hsuen Wu","doi":"10.1080/02770903.2026.2666093","DOIUrl":"10.1080/02770903.2026.2666093","url":null,"abstract":"Objective: This study aimed to evaluate the association between omalizumab use during pregnancy and the risk of adverse fetal outcomes among pregnant women with asthma.Methods: This population-based retrospective cohort study was conducted using data from the 2010-2022 National Health Insurance Research Database and the Birth Certification Application in Taiwan. The study population was pregnant women with asthma. An active-comparator design was employed. Pregnant women who received at least one dose of omalizumab during pregnancy were assigned as the exposure group, while those having at least one prescription for inhaled corticosteroid (ICS) during pregnancy were assigned as the control group. The study outcome was adverse fetal outcomes. Propensity score matching was used to adjust for measurable confounders. Conditional logistic regression models were used to estimate the risk of adverse fetal outcomes.Results: A total of 4,416 pregnant women with asthma were included, with 16 (0.1%) receiving omalizumab and 4,410 (99.9%) using ICS during pregnancy. The risk of adverse fetal outcomes, including pre-term birth (OR, 1.74; 95% CI, 0.46-6.63), low birth weight (OR, 1.04; 95% CI, 0.22-4.87), small for gestational age (OR, 1.11; 95% CI, 0.14-8.98), did not differ between omalizumab and ICS users.Conclusions: Omalizumab was not associated with an increased risk of adverse fetal outcomes among pregnant women with asthma. Further investigation with a larger sample of omalizumab users is warranted.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mid-term impact of COVID-19 related non-pharmaceutical interventions on the incidence of hospitalizations for severe asthma exacerbation in children: a ten-year time-series analysis. COVID-19相关非药物干预措施对儿童严重哮喘加重住院发生率的中期影响：十年时间序列分析

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-05 DOI: 10.1080/02770903.2026.2666087

Marie Facy, Zein Assad, Zaba Valtuille, Naïm Ouldali, Florentia Kaguelidou, Romain Basmaci, Flore Amat

{"title":"Mid-term impact of COVID-19 related non-pharmaceutical interventions on the incidence of hospitalizations for severe asthma exacerbation in children: a ten-year time-series analysis.","authors":"Marie Facy, Zein Assad, Zaba Valtuille, Naïm Ouldali, Florentia Kaguelidou, Romain Basmaci, Flore Amat","doi":"10.1080/02770903.2026.2666087","DOIUrl":"10.1080/02770903.2026.2666087","url":null,"abstract":"Background: The aim of this study was to analyze the temporal association of the national incidence of severe asthma exacerbations (SAEs) in children with the implementation and lifting of NPIs.Methods: We performed a time-series analysis of a national, hospital-based French surveillance system. An SAE was defined as asthma associated with acute respiratory failure. All children aged ≤18 years hospitalized for an SAE in metropolitan France between January 2013 and June 2023 were included. The main outcome was the monthly incidence of hospitalizations for SAEs per 100,000 children, analyzed by a quasi-Poisson regression model, adjusted for pollution exposure. The incidence of hospitalizations for acute pyelonephritis over the same period was analyzed as a control outcome.Results: NPI implementation in March 2020 was associated with a significant decrease in the monthly incidence of SAEs (immediate change, -29.4%; 95%CI -49.4 to -1.5; p = 0.041), and a significant increase following the lifting of the NPIs in March 2021 (immediate change, 59.1%; 95%CI 12.8 to 124.6; p = 0.008), resulting in a non-significant excess compared to the pre-COVID-19 pandemic period trend (+12.3%; 95%CI -12.6 to 44.5; p = 0.36), independently of pollution exposure. No significant changes were observed for acute pyelonephritis hospitalizations over the study period.Conclusions: NPIs were associated with significant changes in the incidence of pediatric SAEs. This unexpected benefit suggests that public health interventions targeting respiratory viruses may reduce the burden of SAEs in children. The mid- and long-term impact of lifting NPIs on SAEs and on the use of healthcare resources should be carefully monitored.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safer use of short-acting beta₂-agonists: perceiving and responding to risk-a qualitative study. 短效β 2激动剂的安全使用：感知和应对风险-一项定性研究。

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-04 DOI: 10.1080/02770903.2026.2660323

Eliza J McEwin, Lorraine Smith, Brett Toelle, Carol Armour, Barbara Mintzes, Bandana Saini

{"title":"Safer use of short-acting beta2-agonists: perceiving and responding to risk-a qualitative study.","authors":"Eliza J McEwin, Lorraine Smith, Brett Toelle, Carol Armour, Barbara Mintzes, Bandana Saini","doi":"10.1080/02770903.2026.2660323","DOIUrl":"10.1080/02770903.2026.2660323","url":null,"abstract":"Methods: People with asthma who overuse SABAs were enrolled into the study through community pharmacist invitation. Semi-structured interviews were completed by telephone or via Zoom. The recordings were transcribed and thematically analyzed using inductive and deductive approaches.Results: Between September 2021 and May 2022, 21 people were interviewed. Data analyses yielded six themes. Three themes related to risk perception including risks related to asthma, medicines, and other factors such as environmental triggers. Three themes related to how people responded to their perceived risk. These included actions taken by some to reduce risk while others chose not to act to reduce risk, despite knowing how to, suggesting a lack of self-efficacy.Conclusions: This is the first study of its kind in a group of Australians who have asthma, a common, as yet incurable, often lifelong chronic health condition. Our interviews yielded rich and sometimes surprising insights into the complexity and number of factors contributing to how people perceive and respond to risks associated with their asthma and with the medicines that they take to manage it.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidden burden: discrepancies between patient-reported and clinically documented severe asthma exacerbations. 隐藏的负担：患者报告和临床记录的严重哮喘恶化之间的差异。

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-01 Epub Date: 2026-01-12 DOI: 10.1080/02770903.2025.2610347

Takeshi Matsumoto, Hiroki Suga, Yuichi Kajiwara, Tomoya Matoba, Akiko Kaneko, Takahiro Fujiki, Yusuke Kusakabe, Emi Nakayama, Naoki Yamamoto, Mayuko Tashima, Chikara Ito, Kensaku Aihara

{"title":"Hidden burden: discrepancies between patient-reported and clinically documented severe asthma exacerbations.","authors":"Takeshi Matsumoto, Hiroki Suga, Yuichi Kajiwara, Tomoya Matoba, Akiko Kaneko, Takahiro Fujiki, Yusuke Kusakabe, Emi Nakayama, Naoki Yamamoto, Mayuko Tashima, Chikara Ito, Kensaku Aihara","doi":"10.1080/02770903.2025.2610347","DOIUrl":"10.1080/02770903.2025.2610347","url":null,"abstract":"Objective: An accurate understanding of asthma exacerbation frequency is essential for optimal management. However, discrepancies may exist between patient-reported and clinically documented exacerbations. This study aimed to investigate the characteristics and associated factors of these discrepancies.Methods: We retrospectively reviewed consecutive patients who regularly visited our hospital for asthma treatment between January 2019 and April 2024 and were followed for one year. Severe exacerbations were defined as short bursts (SB) of systemic corticosteroids lasting ≥3 days or doubling of maintenance oral corticosteroid dose for ≥3 days. Patients were categorized into concordant, under-reporting, or over-reporting groups based on the discrepancies between patient-reported and chart-documented SB counts.Results: Data from 289 patients were analyzed. The level of concordance was weak (κ = 0.26). Among them, 11.4% under-reported and 4.1% over-reported SB events. Among those with objectively confirmed SB, nearly three-quarters under-reported their SB frequency, and over 30% under-reported by at least two episodes. Multivariate analysis revealed that younger age, Global Initiative for Asthma (GINA) step 5, and lower asthma control test (ACT) scores were independently associated with under-reporting by at least one episode (OR = 0.66, 95% CI 0.47-0.93, per 10-year increase; OR = 5.22, 95% CI 1.76-15.01; OR = 0.89, 95% CI 0.80-0.98, per 1-unit ACT increase). Over-reporting was also associated with GINA step 5 and lower ACT scores.Conclusions: A notable proportion of patients exhibited misperception regarding their annual frequency of asthma exacerbations. Particular attention should be paid to patients with severe or poorly controlled asthma, who are more likely to misreport exacerbation events.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"535-542"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breath metabolomics to determine the sputum inflammatory markers of asthma and COPD. 呼吸代谢组学测定哮喘和慢性阻塞性肺病的痰炎标志物。

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-01 Epub Date: 2026-01-16 DOI: 10.1080/02770903.2025.2612527

Ibrahim Baharudin, Mahmoud Dahab, Hamza Mostafa, Maria Basanta, Stephen J Fowler

{"title":"Breath metabolomics to determine the sputum inflammatory markers of asthma and COPD.","authors":"Ibrahim Baharudin, Mahmoud Dahab, Hamza Mostafa, Maria Basanta, Stephen J Fowler","doi":"10.1080/02770903.2025.2612527","DOIUrl":"10.1080/02770903.2025.2612527","url":null,"abstract":"Objective: Differentiating between asthma and chronic obstructive pulmonary disease (COPD) and treating them correctly is challenging because their symptoms overlap and current diagnostic methods are inadequate. We explored the potential of integrating breath metabolomics with sputum inflammatory phenotyping to enhance the discrimination and characterization of respiratory diseases.Methods: Exhaled breath samples were gathered from 74 participants (35 with asthma, 39 with COPD), and sputum samples were examined for eosinophil and neutrophil counts. Orthogonal partial least squares-discriminant analysis (OPLS-DA), logistic regression, and principal component analysis (PCA) were used for the identification of significant volatile organic compounds (VOCs) that discriminate between the diseases, and to determine their relationship to disease state and inflammatory classifications.Results: Breath metabolomics effectively distinct asthma from COPD with 93.2% accuracy, identifying 10 important VOC biomarkers. Significantly, predicting sputum eosinophilia and neutrophilia phenotypes using established thresholds was more accurate (80.6%-90.5%, AUROC 0.67-0.91) compared to directly differentiating the diseases, where each inflammatory subtype presented its own VOC profile. Specific biomarkers, such as allyl methyl sulfide, epizonarene, and camphor, were identified as potential indicators of disease status and inflammatory subtypes.Conclusion: Using breath metabolomics in conjunction with sputum inflammatory phenotyping shows promise in effectively distinguishing between asthma and COPD, as well as identifying inflammatory subtypes, which can aid in creating personalized treatment strategies.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"561-568"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological considerations in evaluating the impact of adenotonsillectomy on asthma control in children. 评估腺扁桃体切除术对儿童哮喘控制影响的方法学考虑。

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-01 Epub Date: 2026-01-14 DOI: 10.1080/02770903.2025.2612523

Jagriti Gairola, Arvind Kumar, Nivedita Nikhil Desai, Dhanya Dedeepya

引用次数: 0

Re: Real-world use of dual biological therapy in severe asthma: insights from four cases. 回复：双重生物疗法在严重哮喘中的实际应用：来自四个病例的见解。

IF 1.3 4区医学

Journal of Asthma Pub Date : 2026-05-01 Epub Date: 2026-01-19 DOI: 10.1080/02770903.2026.2614959

Nav La, Schawanya K Rattanapitoon, Patpicha Arunsan, Nathkapach K Rattanapitoon

引用次数: 0