Journal of Asthma最新文献

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Allergic Diseases and T2DM:A Bidirectional Multivariable Mendelian Randomization Study and Mediation Analysis. 过敏性疾病与 T2DM：一项双向多变量孟德尔随机化研究和中介分析。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2024-11-14 DOI: 10.1080/02770903.2024.2430368

Shukun Zhan, Jinhua Chen, Lingxue Wei, Siyu Gan, Qi Zhang, Haiying Fu

{"title":"Allergic Diseases and T2DM:A Bidirectional Multivariable Mendelian Randomization Study and Mediation Analysis.","authors":"Shukun Zhan, Jinhua Chen, Lingxue Wei, Siyu Gan, Qi Zhang, Haiying Fu","doi":"10.1080/02770903.2024.2430368","DOIUrl":"https://doi.org/10.1080/02770903.2024.2430368","url":null,"abstract":"Background: Clinical studies involving observation have uncovered a mutual relationship between allergic disorders and diabetes, yet the precise causal link remains undetermined.Methods: We conducted two-sample bidirectional Mendelian randomization analyses using single nucleotide polymorphisms (SNPs) associated with allergic conditions (asthma, allergic rhinitis, atopic dermatitis) from genome-wide studies and SNPs related to type 2 diabetes from FinnGen. Initially, we evaluated the causal link between allergic disorders and type 2 diabetes through a univariate Mendelian randomization study, incorporating inverse variance weighting, MR-Egger, and the weighted median estimator. To address potential confounding, we employed multivariate Mendelian randomization. Finally, we validated mediators influencing the correlation between asthma and type 2 diabetes.Results: The Inverse variance weighte method showed that asthma genetically increased the risk of type 2 diabetes (Asthma- type 2 diabetes: β(95%CI)＝0.892(0.152～1.632), P = 0.018). Allergic rhinitis and type 2 diabetes exhibit a mutual protective effect: β(95% CI)＝-1.333(-2.617 to -0.049), P = 0.042；type 2 diabetes - Allergic rhinitis: β(95%CI)＝-0.002(-0.004 to -0.000), P = 0.018). The Multivariable Mendelian randomization study results showed that after after excluding confounding factors, asthma still demonstrates statistical significance in relation to type 2 diabetes. Through mediation analysis, it was discovered that lung function and the percentage of monocytes in leukocytes exert an inhibitory effect on the mediation between asthma and type 2 diabetes.Conclusion: The Multivariable Mendelian randomization study indicates asthma as a risk factor for type 2 diabetes.Lung function, and the percentage of monocytes in leukocytes, play an inhibitory role in asthma and type 2 diabetes mediating effects.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast-Food Consumption and Asthma-Related Emergency Room Visits in California. 加利福尼亚州快餐消费与哮喘相关急诊就诊率。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2024-11-14 DOI: 10.1080/02770903.2024.2429679

Kimberly Valle, Marcela Entwistle, Asa Bradman, Paul Brown, Emanuel Alcala, Ricardo Cisneros

{"title":"Fast-Food Consumption and Asthma-Related Emergency Room Visits in California.","authors":"Kimberly Valle, Marcela Entwistle, Asa Bradman, Paul Brown, Emanuel Alcala, Ricardo Cisneros","doi":"10.1080/02770903.2024.2429679","DOIUrl":"https://doi.org/10.1080/02770903.2024.2429679","url":null,"abstract":"Introduction: Asthma is common, affecting up to 8% of adults in the United States. Several studies have shown an association between poorer diet and asthma. Despite the prevalence of fast-food consumption in the Western diet, research examining fast food consumption and asthma is limited.Objective: This study aimed to examine the association between fast food consumption and asthma-related emergency room visits among adults with asthma in California from 2011-2016.Methods: This cross-sectional study focused on 11,561 adults with asthma in California. Publicly available data from the California Health Interview Survey was used. The independent variable included fast food consumption, and the dependent variable was emergency room visits due to asthma. This study used logistic regression models and controlled for sex, race, self-reported overall health, BMI, and current smoking status. Survey weights were applied to ensure the analysis represented the general population.Results: Consumption of fast food ≥3 times per week was associated with increased odds of emergency room visits for asthma among adults with asthma in California (unadjusted model: OR = 1.64 CI: 1.13-2.40, p = 0.01; adjusted model: ORadj =1.53, CI: 1.03-2.26, p = 0.03).Conclusion: Our findings suggest that high consumption of fast food among adults with asthma may result in higher odds of asthma-related emergency room visits. Thus, decreasing fast food consumption may benefit adults with asthma by reducing emergency room visits.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IMPAIRED RESPIRATORY FUNCTIONS IN CHILDREN WITH CAT SENSITIZATION IN THE EARLY AGES OF CHILDHOOD. 幼年时期对猫过敏的儿童呼吸功能受损。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2024-11-09 DOI: 10.1080/02770903.2024.2428281

Simge Atar Bese, Adnan Mercan, Duygu Erge, Pınar Uysal

{"title":"IMPAIRED RESPIRATORY FUNCTIONS IN CHILDREN WITH CAT SENSITIZATION IN THE EARLY AGES OF CHILDHOOD.","authors":"Simge Atar Bese, Adnan Mercan, Duygu Erge, Pınar Uysal","doi":"10.1080/02770903.2024.2428281","DOIUrl":"https://doi.org/10.1080/02770903.2024.2428281","url":null,"abstract":"Background: To evaluate the respiratory functions in children with cat sensitization accompanying allergic respiratory diseases and to compare these with those of healthy controls, as well as within themselves by classifying according to their diseases, domestic cat exposure, age groups'.Methods: This prospective case-control study included 130 children aged 3-17 years with cat sensitization (CS group) accompanying respiratory allergic diseases and 70 age- and sex-matched healthy controls (HC group). The cases' demographic parameters were recorded, and respiratory functions were analyzed using IOS and spirometry.Results: At IOS evaluation, zR5, R5-20, Fres, and AX values were higher in children in the CS group compared to the HC group (p = 0.029, p = 0.008, p = 0.001, and p < 0.001, respectively), while zX5 and zX20 values were lower (p = 0.001 and p < 0.001). R5-20 and AX were higher in asthma compared to allergic rhinitis (p = 0.008, p = 0.015), but were insignificant compared to asthma and allergic rhinitis coexistent group (p > 0.05). R5-20, Fres, and AX were higher, and zX20 was lower in the pre-school age group (p < 0.001). No correlation was found between zFEV1, zFVC, zFEV1/FVC, zFEF25-75 and zR5 values in the CS group (p > 0.05).Conclusions: Pulmonary resistance was higher and reactance was lower in the entire and peripheral airways in children with cat sensitization accompanying respiratory allergic diseases compared to the healthy controls. Peripheral airway resistance and reactance were more impaired in asthma group compared to allergic rhinitis. However, peripheral airway resistance and main airway reactance were more impaired in the pre-school age group than the older ones.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0