Journal of Asthma最新文献

{"title":"Awareness of wildfire smoke among U.S. adults with and without asthma.","authors":"Maria C Mirabelli, Tia C Dowling, Lauren Freelander, Audrey F Pennington, Scott A Damon","doi":"10.1080/02770903.2025.2487994","DOIUrl":"10.1080/02770903.2025.2487994","url":null,"abstract":"<p><strong>Objective: </strong>To describe awareness of ambient wildfire smoke among U.S. adults with and without asthma.</p><p><strong>Methods: </strong>We analyzed data from the summer wave of the 2021 <i>ConsumerStyles</i> survey, a nationally representative survey of 4085 U.S. adults. Respondents self-reported their asthma status and awareness of wildfire smoke where they lived in the past 12 months. We linked survey responses by zip code of residence with satellite-detected wildfire smoke plume data that estimated the daily maximum smoke plume density over the preceding year. We estimated associations between asthma status and awareness of wildfire smoke across categories of maximum smoke plume density and days with medium- or heavy-density smoke as prevalence ratios (PRs) with 95% confidence intervals (CIs) using predicted marginal probabilities from logistic regression models.</p><p><strong>Results: </strong>Over 98% of the estimated population of U.S. adults lived in a zip code affected by ≥1 day of medium- or heavy-density wildfire smoke, which occurred on an average of 16 days in the past year. Awareness of wildfire smoke was reported by 19% of U.S. adults and was higher among adults with than without asthma (PR: 1.25; 95% CI: 1.01, 1.55), including in zip codes affected by heavy-density smoke (PR: 1.30, 95% CI: 1.04, 1.63) and with 22 or more days of medium- to heavy-density smoke (PR: 1.22, 95% CI: 1.01, 1.47).</p><p><strong>Conclusions: </strong>Although awareness of wildfire smoke was higher among U.S. adults with than without asthma, low percentages of awareness overall indicate a need for health communication about wildfire smoke and its health risks.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and effectiveness of mepolizumab in adult patients with severe asthma with an eosinophilic phenotype from India: a Phase IV, open-label, single-arm, 24-week study (PRISM).","authors":"Priti Meshram, Venkata Nagarjuna Maturu, Rajesh Swarnakar, Pooja Deb, Disha Gupta, Samir Adsule, Rashmi Hegde","doi":"10.1080/02770903.2025.2475452","DOIUrl":"10.1080/02770903.2025.2475452","url":null,"abstract":"<p><strong>Objective: </strong>Existing mepolizumab trials have excluded patients with severe asthma with an eosinophilic phenotype (SAEP) from India. This study (NCT04276233) investigated the safety and effectiveness of mepolizumab in Indian adults with SAEP.</p><p><strong>Methods: </strong>Multi-center, open-label, single-arm, interventional study; patients received 100 mg mepolizumab subcutaneously every four weeks for 24 weeks. Primary endpoint: incidence of adverse events (AEs), serious AEs (SAEs), and AEs of special interest (AESIs). Secondary endpoints: clinically significant exacerbation (CSEs) frequency (including exacerbations requiring hospitalization); change from baseline to Week 24 in forced expiratory volume/second (FEV₁), peak expiratory flow (PEF), and Asthma Control Questionnaire (ACQ-5) scores.</p><p><strong>Results: </strong>Overall, 100 patients received ≥1 mepolizumab dose. Baseline characteristics: female, 51.0%; mean (standard deviation [SD]) age, 44.8 (12.0) years; mean (SD) body mass index, 24.4 (4.7) kg/m². On-treatment AEs and SAEs were reported by 18.0% and 3.0% of patients, respectively; regarding AESIs, 5.0% reported infection and 2.0% reported systemic reaction. One fatal event occurred (unrelated to mepolizumab). CSEs were reported by 8.0% of patients; 2.0% had an exacerbation requiring hospitalization. Least squares (LS) mean change (95% confidence interval) in pre- and post-bronchodilator FEV₁ and PEF by Week 24 was 0.081 L (-0.05, 0.21; <i>p</i> = 0.231), 0.055 L (-0.06, 0.17; <i>p</i> = 0.325), and 13.67 L/min (3.08, 24.25; <i>p</i> = 0.012), respectively. By Week 24, ACQ-5 scores had significantly improved (LS mean change [standard error]: -0.69 [0.121]; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Mepolizumab was well tolerated in Indian adults with SAEP and improved asthma control and health-related quality of life.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the power of gamification: Video game-based breathing vs. conventional breathing exercises on pulmonary and extrapulmonary features in children with asthma.","authors":"Hikmet Ucgun, Buket Akinci, Sena Teber, Guzin Kaya Aytutuldu, Omer Akcal","doi":"10.1080/02770903.2025.2472352","DOIUrl":"10.1080/02770903.2025.2472352","url":null,"abstract":"<p><strong>Objective: </strong>The benefits of incorporating breathing exercises as an adjunct to medical treatment in the management of asthma are well established. Video game-based interventions are notable for the additional advantages they offer to children with chronic respiratory diseases; however, research specifically focusing on children with asthma remains limited. This study aimed to compare the effects of video game-based breathing exercises and conventional breathing exercises on pulmonary and extrapulmonary features in children with asthma.</p><p><strong>Methods: </strong>Thirty-four children with asthma aged 8-18 years were randomly divided into gamification group (GG) and control group (CG). The GG performed video game-based breathing exercises and the CG performed conventional breathing exercises 5 days a week for 8 wk. Pulmonary function, respiratory and peripheral muscle strength, functional capacity, dyspnea, fatigue, asthma control, and quality of life were assessed at baseline and after 8 wk of training.</p><p><strong>Results: </strong>Pulmonary function, respiratory and peripheral muscle strength, functional capacity, and total and physical dimensions of both fatigue and quality of life improved in both GG and CG; however, the improvement in the GG was greater. Significant changes in inspiratory capacity and improvement in dynamic hyperinflation were found only in the GG. Both methods were insufficient in improving dyspnea and asthma control.</p><p><strong>Conclusion: </strong>While breathing exercises are beneficial for children with asthma in improving pulmonary and extrapulmonary features, the video game-based method may provide further improvements. More importantly, the video game-based method is superior to the conventional method as it is also successful in improving dynamic hyperinflation.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"725-736"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive association between dietary total sugar intake and eosinophil counts in asthmatic children and adolescents in the United States: a cross-sectional study.","authors":"Linjun Du, Jinkai Sun, Xiaolan Zhang, Lifang Chen, Chao Che, Rongguan Zhou","doi":"10.1080/02770903.2024.2438095","DOIUrl":"10.1080/02770903.2024.2438095","url":null,"abstract":"<p><strong>Background: </strong>There is not enough data currently available to determine a correlation between eosinophil count and total sugar intake in the diet.</p><p><strong>Objective: </strong>To clarify the relationship between eosinophil levels and overall sugar intake in the diet.</p><p><strong>Methods: </strong>A cross-sectional study that involved 2013 people used data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2020. The relationship between total sugar intake and eosinophil count was investigated using multiple linear regression models. The linear relationship between the two was tested using a restricted cubic spline. Stratified analysis further confirms the stability of the findings.</p><p><strong>Results: </strong>With a mean age of 11.6 ± 4.8 years and 56.5% male participation, all 2013 eligible participants were included. The fully adjusted model indicated a positive correlation between total dietary sugar intake and eosinophil counts (β = 0.41; 95% CI: 0.15 to 0.68; <i>p</i> = 0.002), as determined by multivariable linear regression adjusted for risk variables. A multiple regression model using three quartiles of the total amount of sugar consumed did not change the significance of this outcome. Moreover, by limiting the triple spline, a linear relationship (<i>p</i> = 0.089) was discovered between the overall amount of sugar consumed and the eosinophil count. Subgroup analysis revealed an identical pattern of connection (p-values for all interactions were larger than 0.05).</p><p><strong>Conclusion: </strong>In U.S. children and adolescents with asthma, total dietary sugar intake was positively correlated with eosinophil levels. The findings are significant.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"705-713"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of pediatric uncontrolled asthma in Vietnam.","authors":"Ly Cong Tran, Phuong Minh Nguyen, Nghia Quang Bui, Chau Bao Vo, Giang Thanh Huynh Lam, Y Nhu Thi Nguyen, Thang Hoang Le, Duy-Truong Khac Le, My Hoang Le","doi":"10.1080/02770903.2025.2482988","DOIUrl":"10.1080/02770903.2025.2482988","url":null,"abstract":"<p><strong>Objective: </strong>Uncontrolled asthma profoundly affects quality of life and imposes a significant societal burden. However, reports on its prevalence and contributing factors in Vietnam remain limited. This study aimed to address this gap by investigating the prevalence and factors associated with uncontrolled asthma among children in Vietnam.</p><p><strong>Methods: </strong>An analytical cross-sectional study was conducted involving 344 pediatric asthma patients and their caregivers. The Childhood Asthma Control Test (C-ACT) and Asthma Control Test (ACT) were used to assess asthma control in children aged 4-11 and 12-16 years, respectively. Data on patient, caregiver, and treatment characteristics were collected for analysis. Logistic regression analysis was employed to identify factors associated with uncontrolled asthma.</p><p><strong>Results: </strong>The prevalence of uncontrolled asthma was 40.1%. Factors significantly associated with uncontrolled asthma included previous admissions due to asthma (aOR = 2.80, 95% CI: 1.56-5.04, <i>p</i> < .001), inadequate caregiver knowledge (aOR = 2.86, 95% CI: 1.58-5.19, <i>p</i> < .001), and non-adherence to controller medication (aOR = 1.92, 95% CI: 1.07-3.48, <i>p</i> = .030).</p><p><strong>Conclusions: </strong>The prevalence of uncontrolled asthma in Vietnamese children is quite high. Previous admissions due to asthma, inadequate caregiver knowledge, and controller medication non-adherence were identified as significant factors associated with uncontrolled asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Budesonide/formoterol turbuhaler vs pMDI salbutamol for acute asthma in outpatient emergency department: a prospective, randomized, open-label study.","authors":"Hock Peng Koh, Sin Nan Lai, Woon Wee Chong, Zulsairi Mohd Pauzi","doi":"10.1080/02770903.2024.2438094","DOIUrl":"10.1080/02770903.2024.2438094","url":null,"abstract":"<p><strong>Background: </strong>The Global Initiative for Asthma (GINA) has suggested the need for more studies on inhaled corticosteroid (ICS)-formoterol in the Emergency Department (ED).</p><p><strong>Objectives: </strong>We aimed to compare the outcomes of budesonide/formoterol (160/4.5 mcg/inhalation) turbuhaler versus pressurized metered-dose inhaler (pMDI) salbutamol (100 mcg/puff) in acute asthma in the outpatient ED.</p><p><strong>Methods: </strong>This single-centre, prospective, randomized, and open-label study involved adult asthma patients with mild to moderate asthma exacerbation who attended the outpatient ED of a tertiary hospital in Malaysia. The intervention arm received budesonide/formoterol (Symbicort^® 160/4.5 mcg) turbuhaler, while the control arm received pMDI salbutamol with a valved holding chamber. Stratified randomization with variable baseline ICS use was employed. Direct discharge rate from outpatient ED was the primary outcome. Vital signs pre- and post-treatment between the two arms were also compared.</p><p><strong>Results: </strong>Seventy-four (<i>n</i> = 37 for each arm) asthma patients were recruited. Baseline clinical characteristics were comparable between the two arms. Direct discharge rates from ED were comparable between the intervention (94.6%) and the control (91.9%) arms (<i>p</i> = 1.000). Post-treatment outcomes (respiratory rate, oxygen saturation, peak expiratory flow rate) were similar between the two arms, except for the higher increment of heart rate (<i>p</i> < 0.001) and lesser reduction of blood pressure in the control arm (<i>p</i> = 0.013). Intravenous hydrocortisone use was significantly higher in the control arm (<i>n</i> = 19, 51.4%) than in the budesonide/formoterol arm (<i>n</i> = 6, 16.2%) (<i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Budesonide/formoterol turbuhaler is as effective as pMDI salbutamol in treating asthma exacerbation in the outpatient ED with less effect on heart rate and lower usage of intravenous corticosteroids.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"694-704"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical exercise, systemic inflammation and adult-onset asthma: a 12-year follow-up study.","authors":"Juho Loponen, Iida Vähätalo, Leena E Tuomisto, Onni Niemelä, Lauri Lehtimäki, Mari Hämäläinen, Eeva Moilanen, Hannu Kankaanranta, Pinja Ilmarinen","doi":"10.1080/02770903.2024.2438096","DOIUrl":"10.1080/02770903.2024.2438096","url":null,"abstract":"<p><p><b>Objective:</b> Physical exercise in treatment of asthma is scarcely studied with no clear exercise guidelines for asthmatics. We aimed to investigate the associations between physical exercise frequency, systemic inflammation and asthma control. This has not been previously studied in adult-onset asthma.</p><p><p><b>Methods:</b> This study is part of Seinäjoki Adult Asthma Study (SAAS), where 203 patients with adult-onset asthma were evaluated in 2012-2013. Exercise frequency was recorded with a structured lifestyle questionnaire. Study population was divided into two categories by exercise frequency: Low-frequency group exercised ≤2 times/week and high frequency group >2 times/week. Blood inflammatory markers were measured and IL-6 > 1.55 pg/ml and hs-CRP > 4.12 mg/l indicated systemic inflammation.</p><p><p><b>Results:</b> High-exercise frequency group had lower levels of hs-CRP (<i>p</i> = 0.007), IL-6 (<i>p</i> = 0.015), suPAR (<i>p</i> = 0.008) and adipsin (<i>p</i> = 0.031) and higher levels of adiponectin (<i>p</i> = 0.010) than low-exercise frequency group. In logistic multivariate regression models, higher-exercise frequency lowered odds for elevated hs-CRP (OR = 0.37, 95% CI 0.15-0.94) and IL-6 levels (OR = 0.43, 95% CI 0.20-0.91), after adjusting for possible confounding factors. There was no difference in lung function tests, asthma control test or airways questionnaire 20 scores between the exercise frequency groups. However, differences were found in single symptom questions; high-exercise frequency group had less symptoms during light housework and laughing but experienced more limitation of activity in self-reports.</p><p><p><b>Conclusions:</b> Higher-exercise frequency is associated with lower level of systemic inflammation in patients with adult-onset asthma but no clear association was found to asthma outcomes. Exercise frequency may be associated with lesser amount of some individual asthma symptoms.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"714-724"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maximal exercise capacity, peripheral muscle strength, sleep quality, and quality of life in adult patients with stable asthma.","authors":"Furkan Özdemir, Meral Boşnak Güçlü, Hanım Eda Göktaş, I Kıvılcım Oğuzülgen","doi":"10.1080/02770903.2024.2425369","DOIUrl":"10.1080/02770903.2024.2425369","url":null,"abstract":"<p><strong>Objective: </strong>The prevalence of asthma is increasing gradually worldwide. The pathophysiological process of asthma causes some alterations in the respiratory system and decreases oxygen-carbon dioxide exchange and respiration volume. These alterations may affect maximal exercise capacity, peripheral muscle strength, sleep quality, and disease-specific quality of life but have yet to be comprehensively investigated. To compare maximal exercise capacity, pulmonary function, peripheral muscle strength, dyspnea, sleep quality, and quality of life in adult patients with asthma, healthy controls were aimed.</p><p><strong>Methods: </strong>Forty-one adult stable asthmatic patients (GINA I-III) and 41 healthy subjects were compared. Exercise capacity (cardiopulmonary exercise test [CPET]), pulmonary function (spirometry), peripheral muscle strength (dynamometer), dyspnea (modified Medical Research Council [mMRC] dyspnea scale), quality of life (Asthma Quality of Life Questionnaire [AQLQ]) and sleep quality (Pittsburgh Sleep Quality Index [PSQI]) were evaluated.</p><p><strong>Results: </strong>Peak VO₂, VO₂kg, MET, VE, HR, %VE, %HR, VCO₂ parameters of CPET, FVC, FEV₁, FEF_25-75%, and FEV₁/FVC and quadriceps femoris, shoulder abductors, and hand grip muscle strength were significantly decreased in patients with asthma (<i>p</i> < 0.05). MMRC dyspnea scale score was increased, and AQLQ and PSQI scores decreased in asthma patients (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Cardiac and pulmonary system responses to peak exercise worsened, and maximal exercise capacity and peripheral muscle strength decreased in adult patients with stable asthma. In addition, dyspnea during daily activities increases, and quality of life and sleep quality are impaired. A variety of exercise training that would benefit asthmatic patients' outcomes should be investigated.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"608-620"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic diseases and T2DM: a bidirectional multivariable Mendelian randomization study and mediation analysis.","authors":"Shukun Zhan, Jinhua Chen, Lingxue Wei, Siyu Gan, Qi Zhang, Haiying Fu","doi":"10.1080/02770903.2024.2430368","DOIUrl":"10.1080/02770903.2024.2430368","url":null,"abstract":"<p><strong>Background: </strong>Clinical studies involving observation have uncovered a mutual relationship between allergic disorders and diabetes, yet the precise causal link remains undetermined.</p><p><strong>Methods: </strong>We conducted two-sample bidirectional Mendelian randomization analyses using single nucleotide polymorphisms (SNPs) associated with allergic conditions (asthma, allergic rhinitis, atopic dermatitis) from genome-wide studies and SNPs related to type 2 diabetes from FinnGen. Initially, we evaluated the causal link between allergic disorders and type 2 diabetes through a univariate Mendelian randomization study, incorporating inverse variance weighting, MR-Egger, and the weighted median estimator. To address potential confounding, we employed multivariate Mendelian randomization. Finally, we validated mediators influencing the correlation between asthma and type 2 diabetes.</p><p><strong>Results: </strong>The Inverse variance weighted method showed that asthma genetically increased the risk of type 2 diabetes [Asthma-type 2 diabetes: <i>β</i>(95%CI)＝0.892 (0.152-1.632), <i>p</i> = 0.018]. Allergic rhinitis and type 2 diabetes exhibit a mutual protective effect: <i>β</i>(95% CI)＝-1.333 (-2.617 to -0.049), <i>p</i> = 0.042; type 2 diabetes-Allergic rhinitis: <i>β</i>(95%CI)＝-0.002 (-0.004 to -0.000), <i>p</i> = 0.018. The Multivariable Mendelian randomization study results showed that after excluding confounding factors, asthma still demonstrates statistical significance in relation to type 2 diabetes. Through mediation analysis, it was discovered that lung function and the percentage of monocytes in leukocytes exert an inhibitory effect on the mediation between asthma and type 2 diabetes.</p><p><strong>Conclusion: </strong>The Multivariable Mendelian randomization study indicates asthma as a risk factor for type 2 diabetes. Lung function, and the percentage of monocytes in leukocytes, play an inhibitory role in asthma and type 2 diabetes mediating effects.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"655-673"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships between oxidative balance score and asthma, COPD, with asthma-COPD overlap in American adults: findings from NHANES 2013-2018.","authors":"Shidong Wang, Runxin Jiang, Lin Zhang, Yuelin Cai, Changsheng Zhou, Liang Wu","doi":"10.1080/02770903.2024.2422419","DOIUrl":"10.1080/02770903.2024.2422419","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress plays a crucial role in the development of multiple chronic respiratory diseases. Oxidative Balance Score (OBS) composing of 16 dietary factors and 4 lifestyle factors has been developed to evaluate the effect of oxidants/antioxidants produced by dietary intake and lifestyle habits on the overall oxidative balance. However, the relationships between OBS with asthma, COPD, and asthma-COPD overlap (ACO) are still unclear.</p><p><strong>Methods: </strong>A total of 10,942 adults aged 20 years and older from the 2013-2018 National Health and Nutrition Examination Survey were included in the analyses. ANOVA and chi-square tests were used to compare characteristics between different OBS subgroups. Multiple multivariate logistic regression was used to analyze the associations between OBS and asthma, COPD, and ACO.RCS curves were used to describe the dose-response effect of the associations. Subgroup analyses and interaction effects were employed to reflect the stability of the associations.</p><p><strong>Results: </strong>In the fully adjusted models, OBS was found to be negatively associated with asthma, COPD, and ACO. OBS at Q2, Q3, and Q4 (OR: 0.66, 95% CI: 0.46-0.97) were negatively associated with the risk of asthma. OBS at Q2 and Q4 were negatively associated with the risk of COPD. OBS at Q2 and Q4 were negatively associated with the risk of ACO. The RCS curves reflected the negative dose-response trend of association. Moreover, the associations were stable in various subgroups.</p><p><strong>Conclusion: </strong>The negative associations between OBS and asthma, COPD, and ACO were found in American adults, providing evidence for dietary and lifestyle prevention.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"591-599"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}