Journal of Asthma最新文献

{"title":"Shenzhu Pingxiao formula treats allergic asthma through the HSP90AA1/MAPK14/PTGS2 pathway.","authors":"Jinling Luan, Xiaoxia Zhang","doi":"10.1080/02770903.2025.2562582","DOIUrl":"10.1080/02770903.2025.2562582","url":null,"abstract":"<p><strong>Objective: </strong>Shenzhu Pingxiao formula is a classic Chinese medicinal prescription used for asthma. Given that its mechanism is unclear, this study aimed to evaluate anti-allergic asthma (AA) properties and predict the targets of Shenzhu Pingxiao formula.</p><p><strong>Methods: </strong>Mice were challenged using house dust mites (HDMs). The anti-AA effect of the formula was evaluated by the airway resistance and number of immune cells in bronchoalveolar lavage fluid (BALF). Network pharmacology and molecular docking were used to predict the targets. The real-time reverse-transcription PCR and western blot were applied to analyze key genes and proteins associated with IL-17 signaling pathway.</p><p><strong>Results: </strong>Administration of formula moderated the number of immune cells and reduced the airway hyperresponsiveness. Administration of formula reduced neutrophil recruitment. HSP90AA1, PTGS2, and MAPK14 involved in IL-17 signaling pathway, were predicted to be key targets for this formula. Vina scores in molecular docking were all ≤ -9 for wogonin-HSP90AA1, wogonin-MAPK14, and wogonin-PTGS2 pairs. Shenzhu Pingxiao formula decreased the expression levels of HSP90AA1, PTGS2, and MAPK14 in HDM-challenged mouse lung.</p><p><strong>Conclusions: </strong>Shenzhu Pingxiao formula can reduce neutrophil recruitment and exert anti-AA effects via suppression of HSP90AA1/MAPK14/PTGS2 pathway.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of acupuncture therapy for bronchial asthma: a systematic review and meta-analysis.","authors":"Yicheng Zhu, Jinna Yang","doi":"10.1080/02770903.2025.2513630","DOIUrl":"10.1080/02770903.2025.2513630","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the effectiveness and safety of various acupuncture therapies for bronchial asthma.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in multiple databases to identify systematic reviews and meta-analyses investigating acupuncture therapies for asthma. The therapies included traditional acupuncture, electroacupuncture, warm needling, moxibustion, cupping, auricular acupuncture, scalp acupuncture, acupoint embedding, and acupoint injection. The primary outcome was total efficacy rate, with secondary outcomes including symptom relief rate, pulmonary function tests (FEV1, FVC, FEV1/FVC, PEF), and other relevant measures. The methodological quality of evidence was evaluated using the AMSTAR 2 tool.</p><p><strong>Results: </strong>Fourteen systematic reviews encompassing 167 primary studies with a total of 15,088 participants were included. The meta-analysis revealed that acupuncture therapies significantly improved the total efficacy rate compared to control interventions (Risk Ratio = 1.11, 95% CI: 1.03-1.20, <i>p</i> = 0.006), with remarkably low heterogeneity among studies (I²=0.0%). Acupuncture also showed benefits in symptom relief and some pulmonary function parameters. Regarding safety, only three of the 14 included reviews reported safety outcomes, in addition to an overall low to moderate quality of evidence as assessed by AMSTAR 2, and safety reporting was notably insufficient.</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis suggest that acupuncture therapies may be effective in improving symptoms and some functional outcomes in patients with bronchial asthma. However, due to the limitations in study quality, heterogeneity, and inadequate safety reporting, further high-quality research is needed to confirm these findings and establish optimal acupuncture protocols for asthma management.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1717-1728"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of aortic stiffness in children with asthma by evaluating pulse wave velocity (PWV) using echocardiography.","authors":"Kerem Ertaş, Hülya Köse","doi":"10.1080/02770903.2025.2526374","DOIUrl":"10.1080/02770903.2025.2526374","url":null,"abstract":"<p><strong>Objective: </strong>Asthma bronchiale (AB) is not only limited to the lungs but is also accompanied by systemic inflammation. The aortic stiffness increases with AB. We aimed to evaluate pulse wave velocity (PWV) measurement using an echocardiography device and analyze the factors affecting it.</p><p><strong>Methods: </strong>50 AB and 50 healthy children were included in the study. Hematological tests, lung function tests, and echocardiographic evaluations were performed for all patients. Aortic elasticity parameters such as aortic strain, aortic stiffness index, distensibility, and PWV were evaluated.</p><p><strong>Results: </strong>Mean age in AB and control groups was 12.07 (± 2.65), 12.70 (± 3.59) years, respectively. 63% of the AB group and 55% of the control group were male. Blood lipid and CRP levels were similar in both groups. FVC, FEV1, FEF25-75 were significantly lower in the AB group (<i>p</i> = .002, .000, and .004, respectively). The ventricular function parameters and aortic root and ascending aorta diameters were similar between the groups. The PWV was significantly higher in the AB group (<i>p</i> = .000). There was a correlation between PWV and lung function tests and between FEF25-75 and aortic diameter changes.</p><p><strong>Conclusion: </strong>In AB patients, aortic elasticity parameters were similar in measurements based on diameter change, whereas PWV measurement was performed when aortic stiffness was high. PWV measurement with an echocardiography device is repeatable, practical, and fast at the patient's bedside, and can be performed without additional software and equipment. The PWV obtained using the new measurement technique are closely related to lung function.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1817-1824"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-inhaler triple therapy improves small airway dysfunction in moderate to severe asthma and asthma-COPD overlap: a retrospective cohort study.","authors":"Yumi Fujita, Toshihiro Shirai, Taisuke Akamatsu, Shogo Sakurai","doi":"10.1080/02770903.2025.2513053","DOIUrl":"10.1080/02770903.2025.2513053","url":null,"abstract":"<p><strong>Background: </strong>Medium- or high-dose fluticasone furoate (FF)/vilanterol (VI)/umeclidinium (UMEC) is associated with an improvement in forced expiratory volume in one second (FEV1), a marker of large airway dysfunction. However, the effect of FF/VI/UMEC on small airway dysfunction (SAD) remains unknown.</p><p><strong>Objective: </strong>To clarify the effect of FF/VI/UMEC on SAD in moderate to severe asthma and asthma-chronic obstructive pulmonary disease overlap (ACO) in a retrospective cohort study.</p><p><strong>Methods: </strong>Subjects included 18 moderate to severe asthma and ACO patients who switched from inhaled corticosteroid/long-acting-β2 agonist (ICS/LABA) to FF/VI/UMEC. Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), blood eosinophil counts, total IgE, fractional exhaled nitric oxide, spirometry, and oscillometry were measured and compared before and after FF/VI/UMEC treatment.</p><p><strong>Results: </strong>Markers of SAD, including forced vital capacity (FVC), forced expiratory flow at 25-75% of FVC, respiratory system reactance at 5 Hz (X5), resonant frequency, and low-frequency reactance area (AX), improved significantly after the induction of SITT, in addition to ACT, ACQ, FEV1, and FEV1/FVC. Improvements in FEV1, X5, and AX correlated with improvements in ACT, and improvements in FEV1 and FEV1/FVC correlated with improvements in ACQ.</p><p><strong>Conclusion: </strong>FF/VI/UMEC improved SAD, and its improvement was correlated with improved asthma control in moderate to severe asthma and ACO patients.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1690-1697"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ERS/ATS 2022 bronchodilator response guidelines in asthma control.","authors":"Clara Seghers Carreras, Miguel Jiménez Gómez, Begoña Peña Del Cura, Lucía Ortega Ruíz, Fernando Vargas Ursúa, Cristina Martín-Arriscado Arroba, Carlos Melero Moreno, Rocío Magdalena Díaz Campos","doi":"10.1080/02770903.2025.2513060","DOIUrl":"10.1080/02770903.2025.2513060","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether the bronchodilator response (BDR) according to the new cutoff values is associated with worse asthma control compared with the 2005 definition.</p><p><strong>Methods: </strong>Prospective study on moderate to severe asthma patients under clinical follow-up. Patients were classified based on the BDR using both ERS/ATS 2022 and 2005 thresholds. We collected clinical and functional data, along with exacerbations over a one-year follow-up period.</p><p><strong>Results: </strong>Among the 198 patients included, mean age was 60.2 years-old (SD 16.3), with 74.7% being women and 69.7% having severe asthma. According to the 2005 threshold, 46 (23.2%) showed bronchodilator responsiveness, whereas with the 2022 recommendations decreased to 38 (19.2%). The agreement between the 2005 and 2022 ERS/ATS criteria for BDR positivity was 92.17%, with a Cohen's kappa coefficient of 0.76 (<i>p</i> < 0.001). Using the 2022 cutoff values, patients with BDR had a significantly lower mean asthma control test score (19.9 vs 22.5; <i>p</i> = 0.001), while no difference was observed with the 2005 criteria. The relative risk of exacerbations after one year follow-up was 1.23 (CI 95% 1-1.25) with the 2022 recommendations, compared to 1.09 (CI 95% 0.88-1.38) with the 2005 criteria.</p><p><strong>Conclusions: </strong>The use of the new BDR criteria could provide a valuable marker of asthma control, allowing for better risk stratification and more informed therapeutic decisions.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1712-1716"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploration of how online media portrays asthma and its treatment in New Zealand.","authors":"Amy Hai Yan Chan, Shane Scahill, James Zhu, Ziyi Qin, Christina Lin, Emanuelle Abadi, Saliha Hameedi, Hilary Pinnock, Trudi Aspden","doi":"10.1080/02770903.2025.2514268","DOIUrl":"10.1080/02770903.2025.2514268","url":null,"abstract":"<p><strong>Introduction: </strong>Asthma is one of the most common long-term conditions worldwide. Mass media can influence public perceptions of asthma and treatment, yet there is limited literature on how online media portrays asthma and asthma treatment. The aim was to explore the portrayal of asthma and inhaled treatments in online mass media in New Zealand.</p><p><strong>Methods: </strong>Documents were retrieved over a 5-year period from national patient support organizations and online news outlets. These were screened for inhaler images and mentions of two or more keywords relating to asthma. Manufacturers were contacted to access direct-to-consumer advertisements. A coding instrument was developed to quantitatively analyze the retrieved documents.</p><p><strong>Results: </strong>In total, 124 documents were retrieved and analyzed; 59 from patient support organizations and 65 from online news websites. No online direct-to-consumer advertisements were retrieved. Using inhalers was the most frequently cited asthma management strategy (84%, 84/100). Metered dose inhalers were the most common inhaler device (78%, 175/225) portrayed or mentioned, and blue was the most common color (48%, 109/225). Under half (45%) of metered dose inhalers were shown with a spacer. Online press items contained more emotive themes, such as challenge, fear, and stigma content, than resources from patient support organizations.</p><p><strong>Conclusion: </strong>Blue-colored metered dose inhalers, traditionally associated with relievers, were the most commonly depicted devices in New Zealand online mass media. Most online news articles used emotive language, while patient support organizations used more objective language. How media influences public perceptions of asthma and its treatment needs to be considered by health promoters.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1740-1751"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of disease and unmet clinical needs in pediatric patients with asthma: real-world experience from the United States and five European countries.","authors":"Wei-Han Cheng, Kinga Borsos, Zhixiao Wang, Olivier Ledanois, Rebecca Gall, Mark Small, Richard Humphreys","doi":"10.1080/02770903.2025.2513059","DOIUrl":"10.1080/02770903.2025.2513059","url":null,"abstract":"<p><strong>Objective: </strong>Childhood asthma is a multifaceted, chronic respiratory disease; data on its burden in real-world settings are still scarce. We aimed to assess the burden of pediatric asthma and challenges with current management.</p><p><strong>Methods: </strong>Data were drawn from the Adelphi Disease Specific Programme™, a cross-sectional survey of physicians, pediatric patients with moderate and severe asthma, and their parents/guardians in five European countries and the United States between July 2021 and February 2022 (index). Demographics, clinical characteristics, diagnostic tests, symptoms, treatment patterns, and healthcare resource utilization data were collected from 12 months pre-index period or medical history, stratified by 2- to 5- and 6- to <12-year age groups.</p><p><strong>Results: </strong>Data on 1332 patients were collected (mean age, 7.8 years; physician-confirmed asthma, 80.3%). Overall, 92% of patients were perceived as having moderate asthma; ∼51% had type 2 (T2) comorbidities. Significant inter-country differences (<i>p</i> < .05) were observed for ethnicity, confirmed asthma diagnosis, receipt of asthma medication, and ongoing T2 comorbidities in the 6 to <12 years age group. Approximately, 80% of patients experienced at least one asthma-related symptom in the past 4 weeks, including shortness of breath (21.0%), wheezing (31.0%), and persistent cough (23.0%). Inhaled corticosteroids plus short-acting drugs were prescribed to one-fourth of patients aged 6 to <12 years. Of all, 62% patients had experienced at least one exacerbation in the past 12 months.</p><p><strong>Conclusions: </strong>In our study, a substantial proportion of pediatric asthma patients had T2 comorbidities, high symptomatic burden, and elevated risk of exacerbations, highlighting an unmet need in disease management.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1698-1711"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary inflammatory index and asthmatic patients with sleep disorders in American adults, NHANES 2005-2020.","authors":"Zhouzhou Lu, Yujing Gu, Yun Zhao, Xiaoyi Shen, Honggan Wang, Jun Xie","doi":"10.1080/02770903.2025.2526368","DOIUrl":"10.1080/02770903.2025.2526368","url":null,"abstract":"<p><strong>Background: </strong>Chronic airway inflammation, recognized as the core pathological mechanism of asthma, may disrupt circadian rhythms through neuroimmune modulation mediated by inflammatory mediators. Emerging evidence suggests a markedly elevated prevalence of sleep disturbances among asthma patients, while dietary patterns modulating systemic inflammatory balance present feasible intervention targets. However, the association between Dietary Inflammatory Index (DII) and comorbid sleep disorders in asthma remains underexplored.</p><p><strong>Method: </strong>This cross-sectional study analyzed data from 4,443 asthmatic adults with sleep disorders in NHANES (2005-2020). DII scores were calculated using 28 food parameters from two 24-h dietary recalls. Weighted multivariable logistic regression models were employed to examine DII-sleep disturbance associations with sequential adjustment for demographic, lifestyle, and clinical confounders. Restricted cubic spline (RCS) analysis evaluated nonlinear relationships and inflection points. Gender heterogeneity and subgroup interactions were assessed through stratified analyses.</p><p><strong>Result: </strong>Multivariable analysis demonstrated significant dose-response relationships between elevated DII and sleep disturbance risk (P for trend <0.001). Participants in the highest DII quartile (Q4) demonstrated 47% increased risk compared to Q1 (OR:1.47, 95%CI:1.19-1.83). Full adjustment attenuated this association (Model 2 OR = 1.27, 0.99-1.62; <i>p</i> = 0.06), though borderline significance persisted (P for trend = 0.05). RCS analysis revealed a U-shaped nonlinear association (inflection point: DII = 1; <i>p</i> < 0.05) with significant gender heterogeneity. Males exhibited pronounced U-shaped trends (<i>p</i> < 0.05), contrasting with linear patterns in females (<i>p</i> > 0.05). Poverty-income ratio demonstrated significant interaction (<i>p</i> < 0.05), while other subgroups showed no significant interaction (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>The U-shaped DII-sleep disturbance underscores the critical importance of implementing anti-inflammatory dietary strategies in comprehensive asthma management.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1807-1816"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of asthma age of onset or duration on efficacy of dupilumab in moderate-to-severe type 2 asthma.","authors":"William W Busse, Monica Kraft, Christian Domingo, Inés de Mir-Messa, Diego J Maselli, Xavier Soler, Changming Xia, Nami Pandit-Abid, Juby A Jacob-Nara, Harry J Sacks, Paul J Rowe, Yamo Deniz","doi":"10.1080/02770903.2025.2494233","DOIUrl":"10.1080/02770903.2025.2494233","url":null,"abstract":"<p><strong>Objective: </strong>Age of asthma onset is critical for determining heterogeneous asthma phenotypes. How onset and duration affect therapeutic response is not well understood. Phase 3 QUEST (NCT02414854) and open-label extension TRAVERSE (NCT02134028) studies demonstrated dupilumab's efficacy up to three years in patients ≥12 years with uncontrolled, moderate-to-severe asthma. We assessed how age of asthma onset and asthma duration affect clinical efficacy of dupilumab in patients with moderate-to-severe type 2 inflammatory asthma.</p><p><strong>Methods: </strong>This <i>post hoc</i> analysis included patients with type 2 asthma from QUEST who enrolled in TRAVERSE. Annualized severe exacerbation rates (AER), change from parent study baseline (PSBL) in pre-bronchodilator forced expiratory volume in 1 s (FEV₁), and five-item Asthma Control Questionnaire (ACQ-5) score were assessed according to asthma age of onset (<18 years, 18-40 years, >40 years) and duration (<20 years, ≥20 years).</p><p><strong>Results: </strong>In all subgroups, treatment with dupilumab through QUEST and TRAVERSE progressively reduced AER (TRAVERSE Week 48-96 range, 0.160-0.333), increased pre-bronchodilator FEV₁ (TRAVERSE Week 96 change from PSBL range, 0.20-0.44 L), and reduced ACQ-5 scores (TRAVERSE Week 48 change from PSBL range, -1.63 to -1.84). In patients who received placebo during QUEST, treatment with dupilumab in TRAVERSE improved AER, FEV₁, and ACQ-5 in all subgroups.</p><p><strong>Conclusions: </strong>In patients with uncontrolled, moderate-to-severe type 2 asthma, treatment with dupilumab provides sustained, long-term exacerbation rate reductions and improvements in lung function and asthma control, across all subgroups, with higher reductions in AER and improvements in pre-bronchodilator FEV₁ seen in patients with later onset or longer duration.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1678-1689"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental determinants of asthma among Khasis in Meghalaya, India.","authors":"Prabhnoor Saini, Baname W D Waanbah, N K Mungreiphy","doi":"10.1080/02770903.2025.2519104","DOIUrl":"10.1080/02770903.2025.2519104","url":null,"abstract":"<p><strong>Objective: </strong>Asthma is a major obstructive airway disease, with high morbidity and mortality rates. Indigenous communities, such as the Khasis, face increased asthma risk due to environmental factors, including indoor and outdoor pollutants, allergens, and climate variability. This study investigated the environmental determinants of asthma among the Khasis in Meghalaya, focusing on the impact of these factors on asthma in this population.</p><p><strong>Methods: </strong>A case-control study was conducted among the Khasi population, including 249 asthma cases and 252 controls, aged 10 to 75 years, in Meghalaya, India. Asthma cases were recruited from hospitals, whereas controls were drawn from the community. A validated interview schedule was used to assess indoor, outdoor, and workplace environmental factors. Statistical analysis was performed using IBM SPSS (v26) to evaluate the associations, with significance set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>Lack of sunlight was found to be strongly associated with an increased risk of asthma (AOR = 43.12, <i>p</i> < 0.001). Early-life exposure to passive tobacco smoke (AOR = 12.81, <i>p</i> < 0.001) and past exposures to traditional biomass fuel (wood) (AOR = 8.72, <i>p</i> < 0.001) and cooking smoke (AOR = 3.76, <i>p</i> < 0.01) were other notable risk factors. Exposure to vehicular smoke was also associated with a three times increase in the risk of asthma (AOR = 2.97, <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>The study showed that asthma risk in the Khasi community is significantly influenced by environmental factors, necessitating targeted public health interventions to improve housing conditions, reduce indoor air pollution, and address outdoor environmental risks.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1789-1797"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}