Journal of Asthma最新文献

{"title":"Venous thromboembolism associated with severe dyspnea and asthma in 21,205 adults from the Danish population.","authors":"Kristin Felicia Nilausen, Delia-Ioana Radutiu, Eskild Morten Landt, Suzan Al-Shuweli, Børge G Nordestgaard, Uffe Bødtger, Morten Salling Olesen, Christina Ellervik, Morten Dahl","doi":"10.1080/02770903.2025.2478512","DOIUrl":"10.1080/02770903.2025.2478512","url":null,"abstract":"<p><strong>Background: </strong>Long-term consequences after a pulmonary embolism include lung function deficits, dyspnea, and chronic thromboembolic pulmonary hypertension. Recent studies suggest patients who experience pulmonary embolism may also be at increased risk of asthma.</p><p><strong>Methods: </strong>We tested the hypothesis that individuals with pulmonary embolism or deep vein thrombosis (venous thromboembolism) have lower lung function, or higher risks of dyspnea and asthma using data from 21,205 random adults from the Danish General Suburban Population Study.</p><p><strong>Results: </strong>Prevalences of pulmonary embolism, deep vein thrombosis, and venous thromboembolism were 0.60%, 1.7%, and 1.9%, respectively. Individuals with pulmonary embolism or deep vein thrombosis had FEV₁% predicted of 86% and 89% compared with 95% in individuals without venous thromboembolism (<i>t</i>-test: <i>p</i> < .001). Corresponding values for FVC% predicted were 92% and 94% versus 99% (<i>p</i> < .001). Individuals with versus without venous thromboembolism had adjusted odds ratios for light, moderate, and severe dyspnea of 1.6 (95% CI: 1.1-2.2), 1.8 (1.2-2.6), and 2.6 (1.8-3.8), respectively. Individuals with versus without venous thromboembolism had adjusted odds ratios for asthma and use of asthma medication of 1.6 (1.2-2.2) and 1.9 (1.4-2.6), respectively. The adjusted odds ratio for asthma in individuals with versus without venous thromboembolism was increased among individuals who received no treatment with anticoagulants (2.0, 1.4-3.0) compared to those who received treatment (1.0, 0.6-1.6) (<i>p</i> for interaction = .02).</p><p><strong>Conclusions: </strong>Individuals with venous thromboembolism have lower lung function, 2.6-fold higher risk of severe dyspnea, and 1.6-fold higher risk of asthma in the Danish population.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediation analysis of gut microbiota and plasma metabolites in asthma pathogenesis using Mendelian randomization.","authors":"XuWen Zheng, JinNan Yin, Liang Zhao, YongJun Qian, Jin Xu","doi":"10.1080/02770903.2025.2478504","DOIUrl":"10.1080/02770903.2025.2478504","url":null,"abstract":"<p><strong>Objective: </strong>Asthma is a prevalent chronic respiratory condition with multifactorial pathogenesis. Emerging evidence suggests that gut microbiota and their metabolites influence asthma risk. This study explores the mediation effects of plasma metabolites between gut microbiota and asthma using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>Publicly available genome-wide association study (GWAS) data were analyzed, comprising 5,959 individuals for gut microbiota, 8,299 for plasma metabolites, and 543,586 (86,923 cases and 456,663 controls) for asthma outcomes. MR analyses were conducted to evaluate causal relationships between gut microbiota, plasma metabolites, and asthma. Mediation effects were assessed using the product of coefficients approach, and statistical significance was determined with Bonferroni correction.</p><p><strong>Results: </strong>The MR analysis identified 24 gut microbiomes and 88 plasma metabolites with suggestive associations with asthma. Notably, mediation analysis revealed that the phylum <i>Cyanobacteria</i> reduced asthma risk <i>via</i> the alpha-tocopherol to glycerol ratio (mediated proportion: 37.48%), while the species <i>UBA2922 sp900313925</i> and the order <i>Parachlamydiales</i> increased risk through arachidonate to linoleate (14.62%) and hypotaurine to taurine (29.36%) ratios, respectively.</p><p><strong>Conclusion: </strong>This study underscores the significant role of the gut microbiota-lung axis in asthma pathogenesis. By identifying specific gut microbiota and metabolite pathways, the findings pave the way for innovative biomarkers and therapeutic strategies targeting gut microbiota and its metabolites to manage and prevent asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends and hotspots in mitochondria and asthma: a bibliometric and visualized analysis.","authors":"Leming Huang, Chuyan Wu, Feng Jiang, Xinxin Bu","doi":"10.1080/02770903.2025.2478524","DOIUrl":"10.1080/02770903.2025.2478524","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a complex chronic respiratory disease marked by inflammation, bronchoconstriction, and hyperresponsiveness. Mitochondria, key regulators of energy production, ROS, and apoptosis, are increasingly recognized as crucial in asthma pathophysiology. However, a comprehensive analysis of global research trends in this area is lacking. This study aims to perform a bibliometric and visualized analysis of global research on mitochondria and asthma.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted using Web of Science Core Collection data from 2004 to June 2024. CiteSpace and VOSviewer software were used to examine co-authorship, co-citation, keyword co-occurrence, and thematic clusters.</p><p><strong>Results: </strong>A total of 669 publications were identified. The number of studies grew significantly after 2015, with the United States, China, and the UK leading research. Co-citation and keyword analyses revealed mitochondrial dysfunction, oxidative stress, apoptosis, and airway inflammation as major themes. Emerging areas of interest include mitochondrial biogenesis, NLRP3 inflammasome, and innate immunity. Collaboration among institutions like Harvard University and the Council of Scientific & Industrial Research was significant, and journals, such as European Respiratory Journal and Nature Medicine were highly influential.</p><p><strong>Conclusion: </strong>This study provides an overview of research on mitochondria and asthma, highlighting emerging trends, such as mitochondrial biogenesis and immune pathways. Future research should focus on these areas and the role of environmental triggers in mitochondrial dysfunction, offering valuable insights for therapeutic strategies targeting mitochondria in asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-18"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of short-term exposure to PM_2.5 and its components with hospital admission for asthma in Shanghai: a time-stratified case-crossover study.","authors":"Xuesong Zhou, Jia Qiu, Ning Kang, Jingwei Zhang, Yandan Xu, Jian Zhang, Xiuli Tang, Yinghao Yuchi, Mingjia Xu, Chongjian Wang","doi":"10.1080/02770903.2025.2478503","DOIUrl":"10.1080/02770903.2025.2478503","url":null,"abstract":"<p><strong>Introduction: </strong>Associations between PM_2.5 and the risk of asthma admission have been established in previous researches. However, evidence about the specific impacts of PM_2.5 components on asthma-related hospitalizations across different populations and environments is limited and inconsistent. The purpose of this study was to examine the association between short-term exposure PM_2.5 and its components with asthma hospital admission.</p><p><strong>Method: </strong>A total of 930 people hospitalized for asthma were included in the study in Shanghai between December 2018 and December 2022. Air pollution data were assigned to individuals based on their residential address using the Tracking Air Pollution (TAP) platform. A time-stratified case-crossover design and a conditional logistic regression model were used to estimate the risk of asthma admissions related to exposure to PM_2.5. We also conducted stratified analyzes by age, gender, and season.</p><p><strong>Results: </strong>Each 10 μg/m³ increase in PM_2.5, BC, NO₃^-, NH₄⁺, SO₄^2- and OM at lag-5 day were associated with increased risk of asthma admission, with ORs of 1.04(1.00,1.08), 2.59(0.99,6.76), 1.17(1.02,1.33), 1.33(1.06,1.66), 1.28(1.05,1.55) and 1.16(0.98,1.37), respectively. Stratified analysis showed that PM_2.5 and its components had a more significant impact on the risk of asthma admission for women; individuals aged ≥ 65 years, and during cold seasons at lag-5 day. The results remained stable in the sensitivity analysis.</p><p><strong>Conclusion: </strong>Short-term exposure to PM_2.5 and its components (NO₃^-, NH₄⁺, SO₄^2-) increases hospitalization risk in asthma patients, particularly among women, elder and those admitted during cold seasons. It provides new insight for reducing the asthma burden associated with particulate air pollution.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heated high flow nasal cannula and bilevel positive airway pressure in pediatric asthma exacerbations.","authors":"Shelby Nelipovich, Lauren Ozdowski, Michele E Smith","doi":"10.1080/02770903.2025.2478122","DOIUrl":"10.1080/02770903.2025.2478122","url":null,"abstract":"<p><strong>Objective: </strong>Heated High Flow Nasal Cannula (HHFNC) and Bilevel Positive Airway Pressure (BPAP) are noninvasive respiratory support modalities used in pediatric asthma exacerbations. We aim to examine differences in characteristics and outcomes for patients admitted to the Pediatric Intensive Care Unit (PICU) on standard therapy (ST) alone (continuous albuterol and systemic corticosteroids), ST plus HHFNC, and ST plus BPAP.</p><p><strong>Methods: </strong>This is a retrospective and prospective observational cohort study. Chi-Squared/Fisher's exact and Kruskal Wallis tests were used for categorical and continuous outcomes, respectively.</p><p><strong>Results: </strong>129 patients were included. Younger patients were placed on HHFNC while more severe patients were placed on BPAP. A multiple linear regression controlling for age, sex, race, ethnicity, and exacerbation severity revealed that patients admitted on BPAP had a longer duration of continuous albuterol compared to patients on ST alone (<i>p</i> = 0.02). No differences were found in respiratory support escalation, duration of respiratory support, or adverse events. The BPAP group had the most sedation use and longest length of stay (LOS). Median hourly respiratory rates (RR) increased in the HHFNC group over the first 12 h of admission and remained stable or decreased in the ST and BPAP groups.</p><p><strong>Conclusions: </strong>This study found that BPAP use in pediatric asthma exacerbations is associated with increased exacerbation severity, longer duration of continuous albuterol, increased sedation use, and longer LOS. Although a multiple linear regression analysis was performed to control for multiple covariates including exacerbation severity, it is possible that intrinsic patient characteristics influenced these outcomes rather than BPAP usage.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on the utilization of complementary therapies by adolescents with asthma in an urban population.","authors":"Gary K Soffer, Termeh Feinberg, Hillary Kroll, Marina Reznik","doi":"10.1080/02770903.2025.2475451","DOIUrl":"10.1080/02770903.2025.2475451","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the prevalence and perceived efficacy of complementary and alternative medicine (CAM) use among urban adolescents with asthma, building on a previous landmark study, and to determine if CAM use varied by asthma severity, asthma control test (ACT), and non-CAM prescriptions for asthma treatment.</p><p><strong>Methods: </strong>An adapted survey was completed by 203 patients aged 13-18 years in outpatient specialty and primary care clinics in the Bronx, NY. Demographic information, adherence to prescription(s), ACT, and past year CAM utilization, perceived efficacy of CAM used, and substitution for prescription were assessed <i>via</i> self-report while severity, and related active prescriptions were derived through electronic health records. We conducted logistic regressions to determine if CAM use (yes/no) was associated with ACT (controlled/uncontrolled) or severity (persistent/intermittent).</p><p><strong>Results: </strong>82% of participants utilized at least one form of CAM in the management of their asthma. Mind-body (65%) and natural products (63%) were the most frequent with highest reported perceived efficacy (81%). Only 35% of patients discussed CAM use with their provider. ACT did not vary by CAM use (AOR: 1.57; 95%CI: 0.59, 4.15; <i>p</i> = 0.37), while prescription adherence was associated with a nearly seven-fold increase in CAM use (AOR: 7.79; 95%CI: 3.27, 18.54; <i>p</i><.0001).</p><p><strong>Conclusions: </strong>The prevalence of CAM use amongst Bronx adolescents with asthma has likely largely remained stable since an initial 2002 analysis. Despite a lack of association between CAM use and asthma control, there was a high degree of perceived efficacy. Adolescents who use CAM for asthma management may do so as an overall component of health-promoting behavior such as prescription adherence.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for severe acute pediatric asthma exacerbation in Quanzhou, Southern China.","authors":"Qionghua Chen, Jingyang Zheng, Chunyan Lin, Tianwen Zheng, Qiaoya Hong","doi":"10.1080/02770903.2025.2475457","DOIUrl":"https://doi.org/10.1080/02770903.2025.2475457","url":null,"abstract":"<p><strong>Objective: </strong>To investigate risk factors associated with severe acute asthma attacks in children with asthma over six years of age.</p><p><strong>Methods: </strong>This retrospective study enrolled children aged over six years diagnosed with acute asthma exacerbation at the Department of Pulmonology, Quanzhou Children's Hospital, from January 2012 to September 2024. Data on the patients' clinical manifestations were compared between the mild to moderate and severe asthma attack groups.</p><p><strong>Results: </strong>The average age of the 261 patients was 8.03 ± 1.88 years. The patients were categorized into two groups based on attack severity: mild to moderate (<i>n</i> = 209) and severe (<i>n</i> = 52). Univariate analysis revealed significant differences between the two groups in terms of malnutrition, breastfeeding duration (over three and six months), eosinophil and neutrophil percentages, human rhinovirus (HRV) infection, mediastinal emphysema, and subcutaneous emphysema (<i>p</i> < 0.05). Logistic regression analysis revealed that children over six years of age hospitalized for asthma attacks were more likely to experience severe exacerbations if they had an elevated neutrophil % (OR = 1.040), HRV infection (OR = 5.655), malnutrition (OR = 5.051), or mediastinal emphysema (OR = 9.205). ROC analysis revealed that a neutrophil percentage threshold of 69.35 (the threshold value of neutrophil count over 6 years old is 1.6-8.3 × 10⁹/L) was diagnostically useful for severe asthma, with a sensitivity of 0.750, specificity of 0.617, and an area under the curve of 0.73.</p><p><strong>Conclusion: </strong>The level of neutrophils, history of HRV infection, malnutrition, and mediastinal emphysema are all independent risk factors for a severe acute asthma attack in children aged over six years. Management strategies for asthma should be expanded to focus on high-risk children in order to avoid severe attacks.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling asthma through single-cell RNA sequencing in understanding disease mechanisms.","authors":"Xingxing Yuan, Chaofan Li, Liuxin Yang, Jiawei Gao, Bingyu Wang, Zhuying Li","doi":"10.1080/02770903.2025.2472358","DOIUrl":"10.1080/02770903.2025.2472358","url":null,"abstract":"<p><strong>Objective: </strong>To elucidate the fundamental principles of single-cell RNA sequencing (scRNA-seq) and summarize its application in asthma research, aiming to enhance understanding of asthma pathophysiology and guide future research directions.</p><p><strong>Datasource: </strong>Recent advances and emerging research in scRNA-seq and its role in the pathogenesis of asthma.</p><p><strong>Study selections: </strong>This review incorporates studies that analyzed the heterogeneity of asthma cell types and their functional states using scRNA-seq, with particular emphasis on immune cells and airway remodeling. The selection of specific cell types and markers was based on their relevance to asthma pathogenesis, and we discuss the rationale for favoring certain scRNA-seq technologies in these investigations.</p><p><strong>Results: </strong>ScRNA-seq technology has provided insights into the key mechanisms underlying inflammation and airway remodeling in asthma. It has uncovered the diversity of immune cell subtypes and their specific roles in asthma pathogenesis, revealing critical pathways that contribute to disease progression. These findings offer a theoretical foundation for the development of targeted therapeutic strategies, paving the way for personalized medicine and improved patient outcomes.</p><p><strong>Conclusion: </strong>ScRNA-seq reveals the complex heterogeneity and functional roles of immune cells in asthma, offering key insights into disease mechanisms and the potential for targeted therapies. However, challenges remain, such as the need for further refinement of data integration methods and addressing the limited clinical applicability of current findings. Future research should focus on overcoming these limitations, improving cell type annotation, and expanding studies to include longitudinal and clinical data to better understand disease dynamics and therapy responses.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lingganwuweijiangxin Decoction suppresses allergic airway inflammation in Guinea pigs with cough variant asthma by regulating the treg/Th17 balance and the JAK1/STAT6 signaling pathway.","authors":"Yu Lai, Fengyi He, Jingyi Tang, Xuannan Chen, Shiqing Yuan, Qi Zhang","doi":"10.1080/02770903.2025.2472357","DOIUrl":"https://doi.org/10.1080/02770903.2025.2472357","url":null,"abstract":"<p><strong>Background: </strong>Lingganwuweijiangxin Decoction (LD) is an effective prescription widely used to treat cough variant asthma (CVA) in traditional Chinese medicine, although its mechanisms remain unclear. This study investigates the therapeutic effects and underlying mechanisms of LD on CVA.</p><p><strong>Methods: </strong>A guinea pig CVA model was treated with either LD or budesonide (BUD). Capsaicin aerosol-induced coughs were recorded. Pathological changes were then examined using hematoxylin and eosin staining, transmission electron microscopy, and Wright-Giemsa staining of bronchoalveolar lavage fluid (BALF). Inflammatory cytokines were measured by enzyme-linked immunosorbent assay. mRNA expression levels of transcription factors forkhead box P3 (Foxp3), retinoic acid-related orphan receptor γt (RORγt), Janus kinase 1 (JAK1), signal transducer and activator of transcription 6 (STAT6), the transient receptor potential ankyrin 1 (TRPA1), and transient receptor potential vanilloid 1 (TRPV1) in lung tissue were detected by real-time reverse transcription polymerase chain reaction, and protein levels of these markers were assessed by Western blotting.</p><p><strong>Results: </strong>Compared to the control group, the model group showed significantly more coughs, which were markedly reduced by LD treatment (<i>p</i> = 0.0083 and <i>p</i> = 0.0117). LD treatment also decreased inflammatory cell infiltration, alveolar epithelial hyperplasia, and mitochondrial swelling in ciliated cells, consistent with the lung tissue injury score (<i>p</i> < 0.0001). LD significantly reduced the ovalbumin-induced elevation of TRPA1 (<i>p</i> < 0.01 and <i>p</i> < 0.0001), TRPV1 (<i>p</i> < 0.01 and <i>p</i> < 0.0001), and substance P (SP) levels (<i>p</i> < 0.05). Moreover, LD treatment increased <i>Foxp3</i> mRNA (<i>p</i> = 0.0013) and protein expression (<i>p</i> < 0.0001) and reduced <i>RORγt</i> mRNA (<i>p</i> < 0.0001). LD also decreased <i>JAK1</i> and <i>STAT6</i> transcription (<i>p</i> = 0.0021, <i>p</i> < 0.0001, respectively), with consistent effects observed at the protein level (<i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>LD significantly reduced coughs and airway inflammation in the CVA guinea pig model by regulating TRPA1, TRPV1, SP, regulatory T cell/T helper 17 cell balance, and the JAK1/STAT6 signaling pathway. These effects were comparable to BUD, suggesting that LD may be a viable alternative treatment for CVA.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of biologic therapy on work capacity and workforce attachment in patients with severe asthma.","authors":"Kjell Erik Julius Håkansson, Rikke Ibsen, Niels Steen Krogh, Marianne Baastrup Soendergaard, Susanne Hansen, Anne-Sofie Bjerrum, Anna von Bülow, Ole Hilberg, Anders Løkke, Barbara Bonnesen, Claus Rikard Johnsen, Sofie Lock-Johansson, Lycely Dongo, Maria Bisgaard Borup, Roxana Vijdea, Linda Makowska Rasmussen, Johannes Martin Schmid, Charlotte Suppli Ulrik, Celeste Porsbjerg","doi":"10.1080/02770903.2025.2472356","DOIUrl":"10.1080/02770903.2025.2472356","url":null,"abstract":"<p><strong>Introduction: </strong>Severe asthma impacts work capacity, but little is known about the effects of biologic therapy on patients' ability to work. We aimed to assess the impact of biologic therapy for severe asthma on work capacity and workforce attachment.</p><p><strong>Methods: </strong>This cohort study used the Danish Severe Asthma Register, comprising all Danish patients with severe asthma initiating biologic therapy. Earned income, hours worked, and workforce attachment were tracked in national databases from one year prior to biologic therapy as well as during 2 years of biologic therapy. Outcomes were compared to age-, sex-, cohabitation- and residence-matched controls from the general population.</p><p><strong>Results: </strong>Overall, 381 patients aged 20-62 years (52% females) were included. Annual weeks worked were lower among patients with severe asthma (adjusted incidence rate ratio (aIRR) 0.82 (0.80-0.84)), driven by increases in sick leave (aIRR 2.77 (2.58-2.98)), unemployment (aIRR 1.38 (1.30-1.46)) and disability pension (aIRR 1.85 (1.76-1.94)). After initiating biologic therapy, patients saw modest increases in annual hours worked during the second year of treatment (aIRR 1.03 (1.03-1.04)). However, patients remained at risk for temporary (OR 1.83 (1.15-2.93)) and permanent (OR 2.67 (1.16-6.16)) workforce withdrawal. Patients achieving on-treatment remission worked significantly more hours compared to non- and clinical responders and had lower unemployment-, sick-leave and disability pension rates both at baseline and after two years.</p><p><strong>Conclusion: </strong>Biologic therapy resulted in a modest increase in hours worked, yet patients remain at significant risk of early workforce withdrawal. Patients achieving remission had a stronger attachment to the workforce, also prior to biologic therapy.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}