Journal of Asthma最新文献

{"title":"The asthma-anxiety connection: friends or foes?","authors":"Antia Ferreiro-Posse, Elva Mendoza-Zambrano, Angelica Tiotiu, Francisco-Javier Gonzalez-Barcala","doi":"10.1080/02770903.2026.2654583","DOIUrl":"10.1080/02770903.2026.2654583","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the relationship between anxiety and asthma.</p><p><strong>Methods: </strong>We carried an English scientific literature search using electronic search engines (PubMed). We included articles published in peer-review journals from 2020 to December 2024. In order to perform the search for the most suitable and representative articles, keywords were selected (-asthma‖, and -anxiety‖). The evidence level was assessed according to the criteria of the Oxford Center For Evidence-Based Medicine.</p><p><strong>Results: </strong>Across multiple studies, the prevalence of anxiety among patients with asthma ranged from 13.7% to 54.3%, consistently higher than in the general population. Anxiety was associated with poorer asthma control (lower ACQ/ACT scores), reduced quality of life (AQLQ) and, in some cases, impaired lung function and higher inflammatory markers (hs-CRP, NLR). Depression emerged as the strongest risk factor for anxiety (OR 26.00), while well-controlled asthma (ACT ≥ 20) and allergic asthma were associated with approximately 70% lower risk. Being female and asthma onset occurring between ages 40 and 59 were also linked to higher anxiety prevalence. Screening tools such as the mini-AQLQ, HADS, EQ-5D and PHQ-4 demonstrated potential utility in identifying anxiety in asthmatic populations. In specific subgroups, asthma-related anxiety was associated with increased symptom reporting and exacerbations, even without a deterioration in objective measurements for airway obstruction.</p><p><strong>Conclusions: </strong>Anxiety is a common comorbidity among patients with asthma and it is associated with poorer disease control and a reduced quality of life.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1075-1079"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of obstructive sleep apnea among patients with bronchial asthma.","authors":"S Madhan, Antonious Maria Selvam, Praveen Radhakrishnan, Yuvarajan Sivagnaname, Arivarasan Barathi","doi":"10.1080/02770903.2026.2654590","DOIUrl":"10.1080/02770903.2026.2654590","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine the prevalence, severity, and predictors of OSA among patients with bronchial asthma.</p><p><strong>Methods: </strong>This hospital-based cross-sectional analytical study was conducted over 18 months among 90 adult BA patients diagnosed according to GINA 2019 guidelines. Data collection included a structured questionnaire, clinical examination, spirometry, and the Epworth Sleepiness Scale (ESS). Patients with ESS >10 underwent overnight polysomnography, and OSA severity was assessed using the Apnea-Hypopnea Index (AHI). Bivariate and multivariable analyses were performed to identify predictors of OSA.</p><p><strong>Results: </strong>OSA was diagnosed in 30 of 90 patients (33.3%). OSA severity was mild in 11 (36.7%), moderate in 15 (50.0%), and severe in 4 (13.3%) patients, with 63.3% having moderate-to-severe disease. Excessive daytime sleepiness (ESS >10) was present in 30.0% of participants, all of whom had PSG-confirmed OSA. AHI showed strong positive correlations with ESS score (<i>r</i> = 0.855), asthma severity (<i>r</i> = 0.641), and asthma duration (<i>r</i> = 0.516) (all <i>p</i> < 0.001). On multivariable analysis, GERD (aOR = 4.62; 95% CI: 1.05-20.33; <i>p</i> = 0.043) and severe asthma (aOR = 52.20; 95% CI: 2.92-932.41; <i>p</i> = 0.007) independently predicted OSA.</p><p><strong>Conclusion: </strong>OSA is highly prevalent among patients with bronchial asthma, particularly those with severe disease and GERD. Routine sleep assessment may aid in comprehensive asthma management. Larger longitudinal studies are needed to confirm these findings.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1152-1160"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating Respiratory Emergencies in Children Study (T-RECS): a pilot trial of prehospital treatment for life-threatening pediatric asthma.","authors":"Matt Hansen, Kammy Jacobsen, Spencer Freeman, John Studnek, Doug Swanson, Christine Ranjit, Rachel Crady, Susan J Burnett, Brian Clemency, Sarah Becker, Graham Brant-Zawadzki, Jessica Jung, Bradley J Barney","doi":"10.1080/02770903.2026.2654585","DOIUrl":"10.1080/02770903.2026.2654585","url":null,"abstract":"<p><strong>Objectives: </strong>The Treating Respiratory Emergencies in Children Study (T-RECS) pilot study evaluated the feasibility of a prehospital treatment protocol for life-threatening pediatric asthma, including combined albuterol/ipratropium (DuoNeb) and dexamethasone with a checklist, to inform a future trial.</p><p><strong>Methods: </strong>Prospective, before-and-after study across three US EMS agencies (January 2024-February 2025). We enrolled patients aged 2-17 with severe asthma exacerbations who met specific criteria. The intervention phase introduced the new protocol and checklist. The primary outcome was the hospital admission status collection rate. Secondary outcomes included NIH PROMIS asthma impact score collection, hospital-free days, and ICU-free days. Implementation outcomes were assessed using the RE-AIM framework, including reach, paramedic adoption, and protocol implementation. Paramedic surveys assessed protocol and checklist acceptability. The study was registered on clinicaltrials.gov on 8/10/23 (NCT06074185).</p><p><strong>Results: </strong>The study screened 302 patients and enrolled 43. Hospital admission status was collected for 58% of enrolled patients. There was an observed increase in the use of albuterol/ipratropium (50% to 78.1%) and dexamethasone (41.7% to 65.6%) in the post-intervention phase, with an increase in the combined use of both (16.7% to 53.1%). Paramedic surveys (28% response rate) indicated the protocol was generally easy to follow, and the checklist was helpful. Challenges included time constraints and specific eligibility criteria.</p><p><strong>Conclusions: </strong>This pilot trial evaluated the feasibility and acceptability of implementing a prehospital protocol for severe pediatric asthma. While hospital data collection needs to be improved, these findings provide important considerations for a larger trial to evaluate the impact of this intervention on patient outcomes.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1143-1151"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric asthma hospitalizations and associated factors in California.","authors":"Sasha Singh, Aryaman Trikala, Elvin Hernandez","doi":"10.1080/02770903.2026.2647913","DOIUrl":"10.1080/02770903.2026.2647913","url":null,"abstract":"<p><strong>Objectives: </strong>Asthma is the most common chronic respiratory condition of childhood worldwide. In 2021, about 25% of Californians had at some point been diagnosed with asthma. Between 2008 and 2010, the age-adjusted rate of pediatric asthma deaths was 1.9 in California but 5 in San Bernardino. In this study, we compare rates of pediatric asthma hospitalizations across California counties and examine factors correlating to reduced asthma attacks.</p><p><strong>Methods: </strong>We analyzed two datasets. The first dataset was from the California Health and Human Services Open Data Portal (CA ODP), \"Rates of Preventable Hospitalizations (Age < 18) for Selected Medical Conditions by County.\" Selected counties included Los Angeles, San Bernardino, Kern, Fresno, Alameda, and Santa Clara. The second dataset was from the California Health Interview Survey, Public Use Files (CHIS PUFs), for Teens and Children for years 2018-2022.</p><p><strong>Results: </strong>Risk-adjusted rates showed a noticeable difference between pediatric asthma hospitalizations across California, with the highest rates being seen in Fresno County at 160.0 per 100,000. Reduced asthma attacks in the past year were significantly associated with having a written asthma action plan (<i>p</i> = 0.004) and receiving one from a healthcare provider (<i>p</i> < 0.001). Participants with a usual source of care other than the emergency room (ER) had fewer asthma attacks compared to those without (<i>p</i> = 0.028).</p><p><strong>Conclusions: </strong>Pediatric asthma morbidity remains high throughout different California regions, with increased rates being seen in Fresno. Various factors including consistent healthcare provider access and written asthma action plans play a role in asthma prognosis.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1099-1105"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between waist-to-height ratio and asthma in U.S. children: a cross‑sectional study from NHANES 1999 to 2020.","authors":"Yan Wang, Lei Li, Jun Wang, Hongxia Shen, Xinglin Chen","doi":"10.1080/02770903.2026.2654584","DOIUrl":"10.1080/02770903.2026.2654584","url":null,"abstract":"<p><strong>Background: </strong>In addition to the established link between obesity and asthma, the precise role of adiposity, both total and central, as measured by waist-to-height ratio (WHtR), remains underexplored in pediatric asthma. We aimed to investigate the association between WHtR and asthma in United States (U.S.) children and adolescents.</p><p><strong>Methods: </strong>This cross-sectional study included 34,957 participants aged 3-17 years from the National Health and Nutrition Examination Survey (NHANES, 1999-2020). Multivariable logistic regression models were used to assess the relationship between WHtR and asthma. Generalized additive models and two-piecewise logistic regression were employed to examine nonlinearity.</p><p><strong>Results: </strong>A total of 5,847 (16.7%) children had asthma. Each 0.1-unit increase in WHtR was associated with a 25% higher odds of asthma (OR = 1.25, 95% CI: 1.20-1.30) after full adjustment. A nonlinear relationship was identified with an inflection point at WHtR = 0.467. Below this point, each 0.1-unit increase in WHtR was associated with a 61% increase in asthma odds (OR = 1.61, 95% CI: 1.38-1.88); above it, the increase was 18% (OR = 1.18, 95% CI: 1.11-1.24).</p><p><strong>Conclusion: </strong>In U.S. children and adolescents, WHtR was positively associated with asthma prevalence in a nonlinear pattern. An elevated WHtR was associated with an increased risk of asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1133-1142"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurse-led family interactive intervention in children with bronchopneumonia: a randomized controlled trial.","authors":"Fang Wu","doi":"10.1080/02770903.2026.2654592","DOIUrl":"10.1080/02770903.2026.2654592","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to explore the influence of nurse-led family interactive psychological intervention on negative emotions and treatment coordination degree of hospitalized children with bronchial asthma (BA).</p><p><strong>Design: </strong>Prospective randomized controlled trial.</p><p><strong>Methods: </strong>91 children with BA and their primary caregivers in the hospital from January 2023 to December 2025 were collected by convenience sampling method as study subjects. Children were completely randomized into two groups based on the random number table method. 45 children formed control group and received routine nursing, and the remaining 46 children constituted intervention group and implemented nurse-led family interactive psychological intervention in addition to nursing in control group. The primary clinical outcome was Test for Respiratory and Asthma Control in Kids (TRACK), and the secondary clinical outcomes included Child Medical Fear Scale (CMFS), children' s medication compliance questionnaire, and Family Caregiver Task Inventory (FCTI).</p><p><strong>Results: </strong>The TRACK score in intervention group and control group was statistically significant from the aspect of interaction effect (<i>p</i> = 0.008), and there was an interaction between time effect and grouping effect (<i>p</i> < 0.001). Simple effect analysis found that the TRACK scores at 1 day before discharge, 1 month after discharge and 3 months after discharge in intervention group with (80.52 ± 3.88) points, (84.20 ± 3.64) points, (88.54 ± 3.95) points were higher compared with (77.11 ± 5.61) points, (79.62 ± 4.66) points and (82.80 ± 4.55) points in control group (all <i>p</i> < 0.05). The CMFS score exhibited a statistical significance at 4 time points (Wald <i>χ</i>² = 251.62, <i>p</i> < 0.001). The CMFS scores on the 2^nd day of admission and the 3^rd day of admission and at 1 day before discharge were lower in intervention group than those in control group (all <i>p</i> < 0.05). The score of children' s medication compliance questionnaire in intervention group at 1 day before discharge was higher while the FCTI score was lower compared to control group (both <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This study suggests that nurse-led family interactive psychological intervention can reduce the medical fear of hospitalized children with BA, and enhance the medication compliance and family care ability of children.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1161-1169"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined effect of pulmonary rehabilitation and vitamin D supplementation on pulmonary function tests in asthma patients.","authors":"Ambreen Fatima, Rahul Saxena, Devendra Kumar Singh, Sachin Gupta","doi":"10.1080/02770903.2026.2647908","DOIUrl":"10.1080/02770903.2026.2647908","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the Combined Effect of Pulmonary Rehabilitation and Vitamin D Supplementation on Pulmonary Function Tests in Asthma Patients.</p><p><strong>Methods: </strong>In this 12-week comparative interventional study, 90 adults (aged 30-55 years) with mild to moderate asthma and serum 25(OH)<i>D</i> < 30 ng/mL were randomized into three groups (<i>n</i> = 30 each): Group A (PR + vitamin D), Group B (PR only), and Group C (vitamin D only). PR consisted of supervised exercise sessions three times per week for 8 wk, while vitamin D supplementation was administered as oral cholecalciferol 60,000 IU weekly. Pulmonary function tests (FEV₁, FVC, FEV₁/FVC) and serum 25(OH)D levels were measured pre- and post-intervention. Within-group and between-group differences were analyzed using paired t-tests and ANOVA with Tukey post-hoc tests.</p><p><strong>Results: </strong>All interventions significantly improved FEV₁ and FVC (<i>p</i> < 0.05), with the greatest gains observed in Group A (FEV₁ Δ0.44 ± 0.10 L; FVC Δ0.44 ± 0.12 L; FEV₁/FVC Δ2.7 ± 1.4%), followed by Group B (FEV₁ Δ0.32 ± 0.09 L; FVC Δ0.28 ± 0.11 L; FEV₁/FVC Δ1.4 ± 1.2%) and Group C (FEV₁ Δ0.18 ± 0.08 L; FVC Δ0.15 ± 0.10 L; FEV₁/FVC Δ1.0 ± 1.1%). Between-group comparisons showed Group A > Group B > Group C for pulmonary function improvement (<i>p</i> < 0.001). Serum 25(OH)D increased significantly in Groups A and C (<i>p</i> < 0.001) but remained unchanged in Group B. Compliance was high, and no serious adverse events occurred.</p><p><strong>Conclusion: </strong>Pulmonary rehabilitation and vitamin D supplementation independently improve pulmonary function in patients with mild to moderate asthma, but their combination produces superior outcomes. Integrating vitamin D supplementation into structured PR programs offers a safe, feasible, and potentially synergistic strategy to optimize asthma management.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1080-1089"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between high-sensitivity C-reactive protein levels and asthma in middle-aged and elderly Chinese population: a cross-sectional study based on China Health and Retirement Longitudinal Study (CHARLS).","authors":"Dongfang Ding, Tong Wu, Liwen Zhai, Shuixiang Deng, Xiantao Li, Yi Zhu, Chenyan Qian","doi":"10.1080/02770903.2026.2654594","DOIUrl":"10.1080/02770903.2026.2654594","url":null,"abstract":"<p><strong>Background: </strong>Systemic inflammation has been increasingly recognized as a potential contributor to asthma pathogenesis, particularly in middle-aged and older populations.</p><p><strong>Objective: </strong>This study aimed to examine the association between serum High-sensitivity C-reactive protein (hs-CRP) levels and asthma in middle-aged and older adults in China.</p><p><strong>Methods: </strong>Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2015). After performing 6:1 propensity score matching (PSM), a total of 3,677 participants aged ≥45 years were included in the analysis. Multivariate binary logistic regression was used to assess the association between hs-CRP levels, relevant covariates, and asthma prevalence.</p><p><strong>Results: </strong>Following PSM, asthma patients exhibited significantly higher hs-CRP levels compared to matched non-asthmatic controls. Moderate hs-CRP levels (1-3 mg/L) were associated with increased odds of asthma (OR = 1.54, 95% CI [1.23, 1.93], <i>p</i> < 0.001). High hs-CRP levels (≥3 mg/L) showed a similar association (OR = 1.62, 95% CI [1.24-2.11], <i>p</i> < 0.001). Asthma was also significantly linked to the presence of cardiovascular disease (CVD) (<i>p</i> < 0.001). Additionally, asthma patients had a higher proportion of abnormal white blood cell (WBC) counts compared to non-asthmatic individuals (<i>p</i> = 0.018).</p><p><strong>Conclusion: </strong>Elevated hs-CRP levels are significantly associated with asthma in Chinese adults over 45 years of age. Asthma also shows a notable comorbidity with CVD in this population. Early identification and management of systemic inflammation may help reduce the overall burden of asthma and related conditions in older adults.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1170-1179"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of pentraxin-3 and eosinophil-derived neurotoxin as biomarkers of disease activity in pediatric bronchial asthma.","authors":"Eman Ahmed Abd-Elmawgood, Ahmed Alamir Mahmoud Abdallah, Mohammed H Hassan, Marwa Nasr Abo El-Hasan, Fayed Hm, Nagwan I Rashwan","doi":"10.1080/02770903.2026.2652315","DOIUrl":"10.1080/02770903.2026.2652315","url":null,"abstract":"<p><strong>Background: </strong>Bronchial asthma is a chronic inflammatory airway disorder driven predominantly by Th2-mediated immune responses and eosinophilic activation. Eosinophil-derived neurotoxin (EDN) and pentraxin-3 (PTX3) have been implicated in airway inflammation and remodeling, yet their clinical relevance in children is not fully established.</p><p><strong>Objectives: </strong>To assess serum EDN and PTX3 levels in children with bronchial asthma compared with healthy controls, and to evaluate their diagnostic performance and association with asthma severity and control.</p><p><strong>Methods: </strong>This case-control study included 105 Egyptian children aged 2-18 years (55 asthmatics and 50 healthy controls). Asthma diagnosis, severity, and control were classified according to Global Initiative for Asthma (GINA) guidelines. All participants underwent detailed clinical evaluation, chest radiography, spirometry, and laboratory investigations, including serum EDN, and PTX3 measured by ELISA.</p><p><strong>Results: </strong>Serum EDN and PTX3 levels were significantly elevated in asthmatic children compared with controls (<i>p</i> < 0.0001). EDN showed significant correlations with eosinophil count, IgE, exacerbation frequency, and pulmonary function indices, whereas PTX3 demonstrated weaker clinical associations. ROC analysis showed good discriminatory ability for EDN (AUC = 0.82) and high discrimination for PTX3 (AUC = 0.91) between asthmatic and non-asthmatic subjects, but limited ability of PTX3 to stratify asthma control.</p><p><strong>Conclusion: </strong>EDN and PTX3 are associated with pediatric asthma, reflecting different components of airway inflammation. EDN demonstrated closer relationships with markers of disease activity suggesting its potential role as an adjunct biomarker for monitoring inflammation, while PTX3 primarily differentiated asthmatic from healthy children. These biomarkers should be considered complementary research tools rather than stand-alone diagnostic tests.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1123-1132"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world comparison of inhaled corticosteroid monotherapy versus fixed-dose inhaled corticosteroid/long-acting beta-2 agonist combinations in children aged 6-11 years with persistent asthma.","authors":"Muhammet Kaya, Hülya Anıl, Niyazi Onur Şapcı, Sinem Aslan, Koray Harmancı","doi":"10.1080/02770903.2026.2721169","DOIUrl":"10.1080/02770903.2026.2721169","url":null,"abstract":"<p><p>In children aged 6-11 years with persistent asthma, earlier use of inhaled corticosteroid (ICS)-long-acting beta-2 agonist combination therapies has become a topic of increasing interest in recent years; however, available evidence in this age group remains limited. This study aimed to compare ICS monotherapy, fixed-dose ICS/salmeterol, and fixed-dose ICS/formoterol therapies regarding asthma exacerbations requiring systemic corticosteroids.</p><p><strong>Methods: </strong>This retrospective study included children aged 6-11 years with persistent asthma who were followed for at least 1 year while receiving regular inhaled therapy between January 2021 and August 2024. Patients classified as The Global Initiative for Asthma (GINA) steps 2-4 were grouped according to treatment with ICS monotherapy, fixed-dose ICS/salmeterol, or fixed-dose ICS/formoterol. Asthma exacerbations were assessed based on the need for systemic corticosteroids, emergency department visits, and/or hospitalization.</p><p><strong>Results: </strong>A total of 296 children aged 6-11 years with persistent asthma met the inclusion criteria: 184 received fluticasone propionate (FP), 47 received fluticasone propionate/salmeterol (FP/SAL), and 65 received budesonide/formoterol (BUD/FOR). The groups differed in age at initiation of inhaled therapy (<i>p</i> < 0.001) and duration of follow-up (<i>p</i> = 0.014). Overall, 113 patients (38.2%) experienced at least one asthma exacerbation during follow-up, with no significant difference among FP, FP/SAL, and BUD/FOR groups (<i>p</i> = 0.93). Rates of emergency department visits and hospital admissions were also comparable between groups (<i>p</i> = 0.805 and <i>p</i> = 0.383, respectively), and no significant differences were found regarding systemic corticosteroid-requiring asthma exacerbations.</p><p><strong>Conclusions: </strong>In children aged 6-11 years with persistent asthma, no single controller therapy demonstrated clear superiority in preventing asthma exacerbations.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}