Journal of Asthma最新文献

{"title":"Vocal cord dysfunction/inducible laryngeal obstruction induced by hyperventilation in healthy individuals, people with asthma, and following coronavirus infection.","authors":"Laurence E Ruane, Joo Koh, Malcolm Baxter, Paul Finlay, Kathy Low, Rachael Hillman, Lucy Ruane, Garun Hamilton, Paul Leong, Philip Bardin","doi":"10.1080/02770903.2025.2463979","DOIUrl":"10.1080/02770903.2025.2463979","url":null,"abstract":"<p><strong>Objective: </strong>Vocal cord dysfunction/inducible laryngeal obstruction (VCD/ILO) commonly co-exists with asthma and can start after viral infections. In this setting evidence suggests that dysfunctional breathing may induce the disorder but this possibility has not been researched. We therefore postulated that dysfunctional breathing can induce VCD/ILO, more so in people with asthma and after viral infections.</p><p><strong>Methods: </strong>Eight healthy control subjects, 16 people with asthma and eight people who had recent COVID-19 infection (three with asthma) were recruited. Video-recorded laryngoscopy was performed at tidal breathing and during controlled hyperventilation (used as a proxy for dysfunctional breathing). VCD/ILO was diagnosed by laryngoscopy using accepted criteria and correlated with study cohorts, clinical attributes, asthma severity and spirometry.</p><p><strong>Results: </strong>Overall, 32 subjects were studied. Hyperventilation was verified in all subjects. None of the healthy control group or people with mild asthma developed VCD/ILO during or after hyperventilation but one person with moderate/severe asthma had clear evidence of VCD/ILO. In contrast, in people who had COVID-19 infection, hyperventilation induced VCD/ILO in 3/8 people (38%).</p><p><strong>Conclusion: </strong>These proof-of-concept studies suggest that hyperventilation can provoke VCD/ILO in asthma and after a recent viral infection. How and why VCD/ILO develops is not known and these preliminary findings should prompt further studies of links between dysfunctional breathing, asthma, and viral infections.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1176-1182"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual role of mucosal-associated invariant T cells (MAIT) in asthma.","authors":"M Asghar Pasha, Rawaa Alnabulsi, Aiden Wan, Russell J Hopp, Qi Yang","doi":"10.1080/02770903.2025.2469319","DOIUrl":"10.1080/02770903.2025.2469319","url":null,"abstract":"<p><strong>Objective: </strong>Mucosal-associated invariant T cells (MAIT) are the predominant type of innate-like T cells in humans, and they represent a unique subset of microbiota-dependent invariant T cells. This Commentary reviews recent clinical studies and animal model research elucidating the multifaceted roles of MAIT cells in asthma.</p><p><strong>Method: </strong>A literature search was performed using PubMed and Google Scholar, and covered the period from 1960 to 2024. The search yielded more than 50 articles, and only essential original research articles and selected review articles were evaluated.</p><p><strong>Results: </strong>Recent studies indicate that MAIT cell-derived effector molecules may play dual roles in asthma and allergic airway inflammation. While MAIT cells can produce the anti-inflammatory enzyme IL4I1 and the Th1 cytokine IFN-γ to repress allergic airway inflammation and airway hyperresponsiveness (AHR), they may also secrete IL-17. Which induces neutrophil infiltration and exacerbates AHR. In addition, some clinical studies from the literature search revealed a negative association between MAIT cell abundance and asthma. Regarding allergic airway inflammation, mouse model studies suggested that MAIT cells may play a protective role.</p><p><strong>Conclusion: </strong>These findings raise critical questions as to whether MAIT cells are friend or foe in asthma, and whether distinct subsets of MAIT cells play different roles in allergic airway inflammation. Further studies are needed to better understand the implication of MAIT cells in asthma pathogenesis, particularly in patients with severe asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1095-1100"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of metalworking exposures on respiratory health: the role of fractional exhaled nitric oxide levels.","authors":"Hülya Doğan Tiryaki, Halim İşsever, Osman Küçükkelepçe, Adil Can Güngen, Nefise Şeker, Osman Kurt","doi":"10.1080/02770903.2025.2463966","DOIUrl":"10.1080/02770903.2025.2463966","url":null,"abstract":"<p><strong>Objective: </strong>The significance of measuring Fractional Exhaled Nitric Oxide (FeNO) has grown, particularly in monitoring respiratory diseases like asthma. FeNO levels indicate inflammation and a rise in response to respiratory irritants. This study investigates whether repeated exposure to irritants in metal casting and coating leads to respiratory inflammation and assesses the benefits of including FeNO measurement in periodic occupational health screenings.</p><p><strong>Methods: </strong>This cross-sectional study involved 99 workers aged 18-65 in the foundry and metal coating sectors in the İkitelli Organized Industrial Zone. The study group included 54 workers exposed to metal dust and fumes, while the control group comprised 45 workers in non-exposure roles (e.g. secretarial, assembly, packaging). Data were collected through face-to-face interviews, recording demographics, smoking habits, symptoms. FeNO levels were measured and analyzed with pulmonary function test parameters.</p><p><strong>Results: </strong>FeNO levels were significantly higher in the study group compared to the control group (<i>p</i> = 0.02). No significant relationships were found between FeNO levels and age, height, weight, BMI, waist circumference, years of work, or symptom presence, but a significant negative correlation was observed between FeNO levels and FEV1/FVC. Additionally, current smokers had significantly lower FeNO levels compared to those who had quit or never smoked (study, <i>p</i> = 0.014; control, <i>p</i> = 0.011).</p><p><strong>Conclusions: </strong>Monitoring FeNO levels in occupational health assessments may facilitate early intervention and preventive measures, protecting worker health. Incorporating FeNO measurement into periodic screenings could enhance occupational health practices.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1148-1155"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perspectives on the use of oral corticosteroids in asthma.","authors":"Tonya Winders, Monica Fletcher, John Oppenheimer, Peter Howarth, Zeina Eid Antoun, Thys van der Molen, Liam G Heaney, Mike Thomas","doi":"10.1080/02770903.2025.2466183","DOIUrl":"10.1080/02770903.2025.2466183","url":null,"abstract":"<p><strong>Objective: </strong>Oral corticosteroids (OCS) are used to treat uncontrolled asthma, either as short rescue courses of treatment for severe disease exacerbations, or as long-term maintenance therapy in addition to other controller medications. Although the adverse events (AEs) associated with OCS are well understood by healthcare professionals (HCPs), the patient's perspective may be underappreciated. This review discusses the patient perspective on OCS use.</p><p><strong>Data sources: </strong>A PubMed literature review was performed.</p><p><strong>Study selection: </strong>Articles were selected to include those primarily containing data on patient perspectives on OCS use in asthma or other airway diseases, including qualitative and quantitative studies. Articles including only clinical data and those primarily focused on another indication were excluded. Additional articles meeting the criteria were permitted based on author knowledge and the bibliographies of systematic reviews on other topics.</p><p><strong>Results: </strong>A total of 6066 articles were identified from the PubMed search; 111 were assessed more closely for eligibility. Fourteen articles were eventually selected by the reviewers for inclusion and confirmed by all authors. Several key themes were identified: (1) Key AEs were prominently reported by patients (including weight gain, skin thinning, known osteoporosis/osteopenia, and sleep/mood disturbances); (2) Impact of OCS on day-to-day lives; (3) Patient perceptions of OCS; (4) Effect of perceptions on treatment adherence.</p><p><strong>Conclusion: </strong>HCPs should consider the impact that OCS have on their patients' wellbeing, including short courses. It is essential for HCPs to discuss the short and long-term risks of OCS with patients prior to initiation of treatment and consider alternatives for patients on long-term OCS.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1101-1111"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human blood metabolites and obesity-related asthma-a Mendelian randomization study.","authors":"Xinghui Li, Yunzhi Xiao, Yaoyao Chen, Guansheng Zeng, Lichang Chen","doi":"10.1080/02770903.2025.2469313","DOIUrl":"10.1080/02770903.2025.2469313","url":null,"abstract":"<p><strong>Purpose: </strong>Obesity-related asthma poses serious health problems. Blood metabolite concentrations play crucial roles in its development, but the association with obesity-related asthma risk is unclear. This study aimed to explore the causal effect of blood metabolite levels on this risk.</p><p><strong>Patients and methods: </strong>Using data from the 2023 FinnGen study, which included 345,200 subjects, with 10,306 patients having obesity-associated asthma, we conducted a two-sample Mendelian randomization (MR) analysis. We assessed the causal relationship between 1400 blood metabolites and the risk of developing obesity-associated asthma. The inverse-variance weighting (IVW) method was used to estimate the causal link, with additional tests for heterogeneity and pleiotropy to ensure robustness.</p><p><strong>Results: </strong>The forward MR results showed that 71 metabolites were associated with the risk of developing obesity-related asthma; 57 were previously identified, and 14 were new. Among the known metabolites, 29 were linked to an increased risk, and 28 to a decreased risk. Reverse-MR results identified four metabolites related to the risk of obesity-related asthma.</p><p><strong>Conclusion: </strong>The ratio of proline to trans-4-hydroxyproline and branched chain 14:0 dicarboxylic acid are negatively associated with the risk, while serum concentrations of X-25810 and N-acetyl-L-alanine are positively associated with the risk.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1203-1210"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the peripheral perfusion index in children with bronchial asthma.","authors":"Hatice Bayar Acik, Nuh Yilmaz, Ahmet Kan","doi":"10.1080/02770903.2025.2472355","DOIUrl":"10.1080/02770903.2025.2472355","url":null,"abstract":"<p><strong>Objective: </strong>Peripheral perfusion index (PI) is noninvasive method measuring peripheral blood volume in numerical form and indicating perfusion status. In this study, we have investigated whether the relationship between the measurements of PI and definition of bronchial asthma exacerbation classification and treatment.</p><p><strong>Methods: </strong>This prospective study included in aged 5-12 years children applied to the hospital between January 2020 and June 2020. They were divided into two groups as patients who presented bronchial asthma symptoms and the control group who were selected as children applied to the hospital for routine healthy child follow-up. The severity of the asthma exacerbations was evaluated. Before administering nebulizer therapy, vital signs, oxygen hemoglobin saturation and PI values were recorded. Appropriate nebulizer treatment was initiated for the severity of exacerbation and subsequent changes in the PI values were recorded.</p><p><strong>Results: </strong>Pretreatment PI values were higher in children with asthma than those in healthy children (<i>p</i> = 0.001). The PI measurements of the patients for diagnosing asthma exacerbation showed a statistically significant area under the ROC curve (<i>p</i> = 0.001), and AUC (0.842) values of the 2.25 cutoff point of the PI value were sufficiently high. In the ROC analysis conducted to determine the need for hospitalization in patients presented with asthma exacerbations, the area under the curve was statistically significant (<i>p</i> = 0.020), and AUC (0.830) values of the 3.25 cutoff point of the PI value were sufficiently high.</p><p><strong>Conclusions: </strong>The PI measured in patients presented with asthma symptoms may use a valuable parameter for the diagnosing of asthma exacerbations and making hospitalization decisions.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1240-1245"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effectiveness and safety of mepolizumab in elderly patients with severe asthma: insights from the REDES study.","authors":"Eva Martínez-Moragón, Celia Pinedo, Luis Puente-Maestu, Mariana Muñoz-Esquerre, Ana Gómez-Bastero, Jacinto Ramos, Miguel Díaz-Palacios, Tamara Hermida, David Bañas-Conejero, Santiago Quirce","doi":"10.1080/02770903.2025.2463956","DOIUrl":"10.1080/02770903.2025.2463956","url":null,"abstract":"<p><strong>Objective: </strong>Asthma and severe asthma are problems affecting all age groups, but asthma is frequently undiagnosed in the elderly, due to the poor perception of airflow limitation, lack of fitness, and presence of multiple comorbidities. Even so, the proportion of patients with severe asthma aged ≥65 is significant, and data on efficacy of asthma medications in the elderly are sometimes limited. We report here the effectiveness and safety of mepolizumab (an IL-5 inhibitor) in elderly (≥65 years) patients.</p><p><strong>Methods: </strong>The REDES study was an observational, multicenter study of the effectiveness and safety of mepolizumab 100 mg SC every 4 weeks in 318 severe asthma patients in Spain. This post-hoc analysis compares the effectiveness and safety of patients ≥65 years old to patients <65 years after 12 months of mepolizumab treatment.</p><p><strong>Results: </strong>27% of patients were ≥65 years old, compared with 73% of patients <65 years. Elderly patients showed a trend toward less frequent comorbid nasal polyps (<i>p</i> = 0.06) and a lower proportion of atopic sensitization (as detected by prick test or specific IgE) (<i>p</i> = 0.02). Similar improvements were noted in ACT score (<i>p</i> < 0.0001), comparable exacerbation reductions (<i>p</i> < 0.0001), and lung function parameters (<i>p</i> < 0.04 in elder group and <i>p</i> < 0.0001 in younger elder group), although an apparent greater reduction of OCS daily dose was observed in elder patients (<i>p</i> = 0.0002). No new safety signals were reported in the elderly population.</p><p><strong>Conclusions: </strong>This study further supports mepolizumab as an effective and well tolerated therapy in the difficult to treat population of elderly patients with severe asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1128-1132"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing serum and biopsy biomarkers for predicting allergic asthma severity: a comprehensive study.","authors":"Zainab Khaleel Mohammed, Shukur Wasman Smail, Christer Janson, Kawa Amin","doi":"10.1080/02770903.2025.2463953","DOIUrl":"10.1080/02770903.2025.2463953","url":null,"abstract":"<p><strong>Background: </strong>Allergic asthma is a chronic respiratory condition characterized by inflammation and constriction of the airways in response to specific allergens. This study aimed to assess serum and biopsy biomarkers to predict the severity of allergic asthma.</p><p><strong>Methods: </strong>A total of 18 allergic asthma patients and 15 healthy controls (HCs) were included from April to August 2021 in Par hospital, Erbil-Iraq. The blood and bronchial biopsy were taken, the serum biopsy marker were assessed <i>via</i> ELISA and immunohistochemistry (IHC) methods.</p><p><strong>Results: </strong>It was showed no significant difference in age between allergic asthma patients and HCs (<i>p</i> = 0.285), although patients with allergic asthma had a significantly higher BMI (<i>p</i> = 0.028). Allergic asthma patients exhibited significantly elevated levels of serum eosinophil cationic protein (ECP), fibroblast growth factor 23 (FGF-23), and fibroblast growth factor 18 (FGF-18) compared to HCs (<i>p</i> < 0.0001). IHC analysis revealed significantly higher levels of myeloperoxidase (MPO) positive cells, activated eosinophils (EG2) positive cells, mast cells, FGF-18 positive cells, and FGF-23 positive cells in bronchial biopsy samples from allergic asthma patients compared to HCs (<i>p</i> < 0.0001). Additionally, serum FGF-18, EG2 positive cells, and FGF-18 positive cells were negatively correlated with lung function (FEV1/FVC), while asthma score showed a significant positive correlation with these markers.</p><p><strong>Conclusion: </strong>Serum FGF-18, EG2 positive cells, and FGF-18 positive cells are promising biomarkers that can predict improvements in the FEV1/FVC ratio and reductions in asthma score, highlighting their potential utility in assessing the severity of allergic asthma and guiding treatment decisions.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1119-1127"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry.","authors":"Zeynep Celebi Sozener, Ipek Kıvılcım Oguzulgen, Funda Seher Ozalp Ates, Ayse Baccioglu, Serap Argun Barıs, Dane Ediger, Fatma Esra Gunaydın, Can Sevinc, Ummuhan Seker, Bilge Yılmaz Kara, Sengul Beyaz, Dilsad Mungan, Omur Aydin, Derya Gokmen, Gozde Koycu Buhari, Bilun Gemicioglu, Ismet Bulut, Cihan Orcen, Secil Kepil Ozdemir, Metin Keren, Ebru Damadoglu, Tugce Yakut, Ayse Fusun Kalpaklioglu, Sumeyra Alan Yalim, Insu Yilmaz, Ilkay Koca Kalkan, Mehmet Atilla Uysal, Elif Yelda Ozgun Niksarlioglu, Ali Fuat Kalyoncu, Gul Karakaya, Muge Erbay, Sibel Nayci, Fatma Merve Tepetam, Asli Akkor Gelincik, Hulya Dirol, Ozlem Goksel, Selen Karaoglanoglu, Ferda Oner Erkekol, Sacide Rana Isik, Fusun Yildiz, Yasemin Yavuz, Dilek Karadogan, Nurgul Bozkurt, Ilknur Basyigit, Elif Yilmazel Ucar, Tuba Erdogan, Mehmet Polatli, Murat Turk, Leyla Pur, Zeynep Yegin Katran, Yonca Sekibag, Enes Furkan Aykac, Ozcan Gul, Ali Cengiz, Bulent Akkurt, Seyma Ozden, Semra Demir, Derya Unal, Ayse Feyza Aslan, Ali Can, Reyhan Gumusburun, Gulhan Bogatekin, Hatice Serpil Akten, Sinem Inan, Munevver Erdinc, Aliye Candan Ogus, Murat Kavas, Demet Polat Yulug, Mehmet Erdem Cakmak, Saltuk Bugra Kaya, Gulistan Alpagat, Eylem Sercan Ozgur, Oguz Uzun, Sule Tas Gulen, Gulseren Pekbak, Deniz Kizilirmak, Yavuz Havlucu, Halil Donmez, Bahar Arslan, Gulden Pacaci Cetin, Sadan Soyyigit, Gulden Pasaoglu Karakis, Adile Berna Dursun, Resat Kendirlinan, Ayse Bilge Ozturk, Gokcen Omeroglu Simsek, Oznur Abadoglu, Pamir Cerci, Taskin Yucel, Irfan Yorulmaz, Zahide Ciler Tezcaner, Emel Cadalli Tatar, Ahmet Emre Suslu, Serdar Ozer, Engin Dursun, Arzu Yorgancioglu, Gulfem Elif Celik","doi":"10.1080/02770903.2025.2466182","DOIUrl":"10.1080/02770903.2025.2466182","url":null,"abstract":"<p><strong>Objective: </strong>The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma.</p><p><strong>Methods: </strong>This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR). Clinical presentation, disease control, severity, and demographics of obese and non-obese (normal-weight, overweight) patients were compared.</p><p><strong>Results: </strong>The obesity rate in TAAR was 32.2% (<i>n</i> = 619/1919; 18-83 years; 527 F/92 M). Patients with asthma and obesity had higher rates of childhood obesity, longer symptom duration, later onset of asthma, and more severe asthma. These patients were more likely to be female, older, less educated, and live in rural areas. Patients with obesity had more scheduled visits and emergency visits compared with non-obese patients, but similar asthma control, oral corticosteroid use, hospitalizations, intensive care unit admissions, and unscheduled visits. They also had a higher frequency of T2-high but lower frequency of possible T2-low phenotypes compared with normal-weight asthmatics. The risk of severe asthma in patients with obesity was 6.04 times higher for allergic than non-allergic patients and 3.58 times higher for the T2-high phenotype than for possible T2-low phenotypes. A one-unit increase in the asthma control test reduced the risk of severe asthma by 22%.</p><p><strong>Conclusions: </strong>A good definition of this phenotype is important to ensure that appropriate treatment strategies are implemented to achieve the control goal. We also believe that prevention of childhood obesity is an effective and pivotal strategy to achieve the goal of asthma control.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1183-1194"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of early adolescents with allergic asthma receiving online education from peers: a qualitative phenomenological study.","authors":"Pelin Karatas, Husniye Calisir, Pinar Uysal","doi":"10.1080/02770903.2025.2472353","DOIUrl":"10.1080/02770903.2025.2472353","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the experiences and opinions of adolescents aged 10-14 years with allergic asthma in Turkiye about the online asthma education they received from their peers.</p><p><strong>Methods: </strong>Eleven adolescents who had previously received peer education concerning asthma participated in this qualitative phenomenological study. These were asked semi-structured questions to evaluate peer education through a video chat program. Qualitative data were analyzed using N'Vivo (Version 12.5) software.</p><p><strong>Results: </strong>Four main themes and 12 sub-themes were identified in the light of the data obtained from the interviews. 'The importance of friends' theme (T1) was established for the sharing, listening to their thoughts, caring about their opinions, and taking their suggestions into consideration sub-themes. 'The comfort derived from being with peers' them (T2) was established for the facilitating learning, feeling not alone, feeling understood, and motivation for recovery sub-themes. The reliability of information' theme (T3) was established for the believing in the reliability of the information and applying the information learned sub-themes, and the 'opinions about the educator' theme (T4) for the experiences with peer educators and suggestions for peer educators sub-themes.</p><p><strong>Conclusions: </strong>The experiences and opinions of the adolescents with allergic asthma in this study were highly favorable regarding the education provided by their peers about the disease in an online environment.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1221-1230"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}