Journal of Asthma最新文献

{"title":"Association between serum Klotho concentrations and asthma in middle-aged and older Americans: a cross-sectional study.","authors":"Jie Wang, Yunzhe Li, Hailong Zhong, Junyi Li, Xiuyun Li, Chenxi Wang, Xixi Zhou, Kang Zou","doi":"10.1080/02770903.2026.2721171","DOIUrl":"10.1080/02770903.2026.2721171","url":null,"abstract":"<p><p>Klotho, an anti-aging protein with anti-inflammatory and antioxidant properties, plays a role in asthma pathophysiology. This study investigated whether serum Klotho concentrations are associated with asthma prevalence among middle-aged and elderly Americans.</p><p><strong>Methods: </strong>This cross-sectional study included 12,442 participants from the National Health and Nutrition Examination Survey (2007-2016). Serum Klotho was measured by ELISA and asthma was self-reported. Weighted multivariable logistic regression adjusting for demographic and clinical confounders was performed to evaluate associations. Smoothed curve fitting assessed potential nonlinear relationships.</p><p><strong>Results: </strong>After adjustment for confounding variables, a significant inverse association was found between serum Klotho concentration and asthma incidence. Specifically, each unit increase in log-transformed Klotho was associated with a 48% reduction in asthma risk (odds ratio: 0.52; 95% confidence interval: 0.38-0.69). Participants in the lowest Klotho quartile had a higher prevalence of asthma than those in the highest quartile (odds ratio, 0.58; 95% confidence interval: 0.45-0.76). Subgroup analyses revealed associations between a history of cardiovascular disease and drinking status. Notably, smoothing curve analysis did not reveal a nonlinear association between Klotho levels and asthma prevalence.</p><p><strong>Conclusions: </strong>Lower serum Klotho levels are significantly associated with higher asthma prevalence in middle-aged and elderly Americans. Klotho may serve as a potential biomarker for asthma risk assessment, though prospective cohort studies are needed to establish causality.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biologic-assisted house dust mite immunotherapy in allergic asthma: could it provide a bridge toward de-escalation?","authors":"Simon Høj, Howraman Meteran","doi":"10.1080/02770903.2026.2730877","DOIUrl":"10.1080/02770903.2026.2730877","url":null,"abstract":"","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-3"},"PeriodicalIF":1.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactive associations of atmospheric humidity and air pollutants with self-reported chronic lung disease risk: Evidence from a nationwide population-based study in China.","authors":"Zonghui Yang, Xiaoxia Li","doi":"10.1080/02770903.2026.2721168","DOIUrl":"10.1080/02770903.2026.2721168","url":null,"abstract":"<p><p>To evaluate the associations of multidimensional atmospheric humidity indicators and air pollution with self-reported chronic lung disease (CLD) among middle-aged and older adults in China.</p><p><strong>Methods: </strong>Data from 16,204 adults aged ≥45 years from the 2011, 2013, and 2015 waves of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed. Annual exposures to six air pollutants (CO, NO₂, O₃, PM₂.₅, PM₁。, SO₂) and six humidity indicators (RH, AVP, VPD, DPT, MR, SH) were estimated at 1-km resolution. Multivariable logistic regression and restricted cubic spline models were applied. Stratified and sensitivity analyses were conducted.</p><p><strong>Results: </strong>Higher concentrations of CO, NO₂, O₃, PM₂.₅, and SO₂ were linearly associated with increased self-reported CLD risk, while PM₁。 showed an approximate U-shaped relationship. Each interquartile-range increase in air pollutant concentrations was associated with an 18-45% higher odds of self-reported CLD. AVP, VPD, DPT, MR, and SH were positively associated with self-reported CLD risk, whereas RH exhibited an inverted U-shaped pattern. Weighted quantile sum analyses showed significant positive associations for both air pollution and humidity mixtures. A significant interaction between RH and sex was observed. Sensitivity analyses across different lag structures confirmed that air pollutants and atmospheric humidity were consistently associated with self-reported CLD risk.</p><p><strong>Conclusions: </strong>Long-term exposure to ambient air pollution and multidimensional humidity indicators was independently associated with higher self-reported CLD risk, highlighting the importance of considering meteorological factors in disease prevention.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-15"},"PeriodicalIF":1.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation of an electronic medical record-based asthma registry at a tertiary care center.","authors":"Michael Aw, Sumiya Lodhi, Marielena Dibartolo, Sandra Giangioppo, Nick Barrowman, Anne Tsampalieros, Madhura Thipse, Dhenuka Radhakrishnan","doi":"10.1080/02770903.2026.2647917","DOIUrl":"10.1080/02770903.2026.2647917","url":null,"abstract":"<p><strong>Objective: </strong>Large population-based asthma registries improve disease understanding and management and can be developed through the secondary use of electronic medical records (EMRs). We have created an <i>Epic</i>-EMR registry of children treated for asthma at the Children's Hospital of Eastern Ontario (CHEO). This study's objective was to validate the Epic-EMR asthma registry by comparing it against expert clinical asthma diagnoses.</p><p><strong>Methods: </strong>The sample included children aged 0-18 years. We randomly selected 200 children from the Epic-EMR asthma registry, 200 children with non-asthma respiratory conditions, and 200 children with non-asthma, non-respiratory diagnoses. All asthma diagnoses were verified by two blinded pediatric respirologists based on data abstracted from the electronic chart.</p><p><strong>Results: </strong>In total 598 children were included for analysis. The <i>Epic</i>-EMR asthma registry had a positive predictive value of 0.91 (95%CI 0.86-0.94) and negative predictive value of 0.92 (95%CI 0.89-0.94). Correcting for the proportion of CHEO patients in the asthma registry (6.6%), the estimated specificity was 0.99 (95%CI 0.99-0.99) and sensitivity was 0.44 (95%CI 0.36-0.53). When age-stratified, the specificity was 0.99 (95%CI 0.99-0.99) and sensitivity was 0.39 (95%CI 0.29-0.50) for participants aged 0 to <6 years, and 0.99 (95%CI 0.98-0.99) and 0.5 (95%CI 0.37-0.63) for participants aged 6-18 years.</p><p><strong>Conclusion: </strong>The <i>Epic</i>-EMR asthma registry accurately identifies children with asthma. With a very high specificity, positive and negative predictive value, this tool is appropriate to use for clinical care and research.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1106-1113"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the visceral fat-to-muscle ratio and severe exacerbation of asthma: a cross-sectional study.","authors":"Xia Su, Lingyan Xie","doi":"10.1080/02770903.2026.2647911","DOIUrl":"10.1080/02770903.2026.2647911","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a prevalent chronic inflammatory airway disease globally, and its acute exacerbations significantly increase healthcare burdens. In recent years, abnormal body composition has been recognized as a potential contributor to the onset and progression of asthma. The Visceral Fat-to-Muscle Ratio (VMR) is a composite indicator reflecting sarcopenic obesity. This study primarily aims to evaluate the relationship between VMR and asthma, as well as asthma-related events.</p><p><strong>Methods: </strong>This study utilized cross-sectional data from the 2011-2018 NHANES database, including adult participants. Multivariable logistic regression models were employed to assess the association between VMR and asthma risk, as well as acute exacerbations in the past year. Additionally, restricted cubic spline (RCS) functions were applied to examine potential nonlinear relationships between VMR and asthma risk, and subgroup analyses were conducted to verify the robustness of the results.</p><p><strong>Results: </strong>The study analyzed data from 7352 participants. Further classification into stable asthma and asthma exacerbation groups revealed that higher VMR levels were significantly associated with an increased risk of asthma exacerbations (OR = 1.33, 95% CI: 1.12-1.57). Compared to the lowest group, participants in the highest VMR quartile had a 94% higher risk of asthma exacerbations (OR = 1.94; 95% CI: 1.18-3.18, <i>p</i> < 0.01), whereas no significant association was observed during the stable phase of asthma. RCS analysis indicated a linear relationship between VMR and asthma risk, with the association remaining statistically significant.</p><p><strong>Conclusion: </strong>This cross-sectional study is the first to identify a significant association between VMR and the risk of asthma exacerbations, suggesting that abnormal body composition may be an important factor influencing asthma attacks. As a convenient and modifiable body composition indicator, VMR holds potential clinical value in risk identification and non-pharmacological management of asthma populations.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1090-1098"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing causal relationships between oral microbiota and asthma: evidence from two-sample mendelian randomization analysis.","authors":"Zi-Feng Wei, Jia-Pei Wuzhang, Yi-Ting Huang, Hao-Yu Li, Jian Chen","doi":"10.1080/02770903.2026.2647919","DOIUrl":"10.1080/02770903.2026.2647919","url":null,"abstract":"<p><strong>Objective: </strong>Accumulating evidence indicates that alterations in the composition of the oral microbiota are associated with asthma. However, it remains uncertain whether these associations reflect causal relationships. The study aimed to investigate the causal relationship between oral microbiota and asthma at the genetic level.</p><p><strong>Methods: </strong>A two-sample Mendelian randomization (MR) analysis was conducted using genome-wide association studies (GWAS) data on the oral microbiota and asthma within the East Asian population. Inverse-variance weighted (IVW), MR-Egger, weighted median, and weighted mode methods were utilized to examine the potential causal relationship between oral microbiota and asthma. Additionally, pleiotropy and heterogeneity tests were conducted to assess the robustness of the findings.</p><p><strong>Results: </strong>Among the 3,117 bacterial taxa analyzed, nine genera, comprising 18 oral microbiota, exhibited causal effects on asthma. Twelve oral microbiota, including <i>Streptococcus_umgs_1936</i>, <i>Porphyromonas_mgs_3421</i>, and <i>Campylobacter_A_umgs_3382</i>, demonstrated positive causal associations with asthma. Conversely, six oral microbiota, including <i>Parvimonas_umgs_2046</i>, and <i>Parvimonas_umgs_3325</i>, were negatively related to asthma. Enrichment was observed in three genera: <i>Parvimonas</i>, <i>Streptococcus</i>, and <i>TM7x</i>. No pleiotropy or heterogeneity was detected among the instrumental variables (IVs) throughout the study.</p><p><strong>Conclusions: </strong>The findings suggest a causal relationship between oral microbiota and asthma. These results provide novel insights into the mechanisms underlying asthma that are mediated by the oral microbiota.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1114-1122"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild asthma - a deceptive danger.","authors":"Daniel J Tan, Shyamali C Dharmage","doi":"10.1080/02770903.2026.2647916","DOIUrl":"10.1080/02770903.2026.2647916","url":null,"abstract":"<p><p>Asthma remains one of the commonest chronic diseases globally, affecting over 339 million people across all age-groups. It is the most prevalent chronic respiratory disease in children, and second most common in adults. While most asthma patients are labelled as having 'mild' disease, strong evidence now shows that so-called 'mild asthma' is neither benign nor stable, and can result in serious adverse outcomes including severe exacerbations, persistent airflow limitation, and even death. Here, we challenge the concept of mild asthma as a low-risk condition, highlight evidence for its hidden dangers, and propose an evidence-based approach to redefine and manage the condition.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1071-1074"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The asthma-anxiety connection: friends or foes?","authors":"Antia Ferreiro-Posse, Elva Mendoza-Zambrano, Angelica Tiotiu, Francisco-Javier Gonzalez-Barcala","doi":"10.1080/02770903.2026.2654583","DOIUrl":"10.1080/02770903.2026.2654583","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the relationship between anxiety and asthma.</p><p><strong>Methods: </strong>We carried an English scientific literature search using electronic search engines (PubMed). We included articles published in peer-review journals from 2020 to December 2024. In order to perform the search for the most suitable and representative articles, keywords were selected (-asthma‖, and -anxiety‖). The evidence level was assessed according to the criteria of the Oxford Center For Evidence-Based Medicine.</p><p><strong>Results: </strong>Across multiple studies, the prevalence of anxiety among patients with asthma ranged from 13.7% to 54.3%, consistently higher than in the general population. Anxiety was associated with poorer asthma control (lower ACQ/ACT scores), reduced quality of life (AQLQ) and, in some cases, impaired lung function and higher inflammatory markers (hs-CRP, NLR). Depression emerged as the strongest risk factor for anxiety (OR 26.00), while well-controlled asthma (ACT ≥ 20) and allergic asthma were associated with approximately 70% lower risk. Being female and asthma onset occurring between ages 40 and 59 were also linked to higher anxiety prevalence. Screening tools such as the mini-AQLQ, HADS, EQ-5D and PHQ-4 demonstrated potential utility in identifying anxiety in asthmatic populations. In specific subgroups, asthma-related anxiety was associated with increased symptom reporting and exacerbations, even without a deterioration in objective measurements for airway obstruction.</p><p><strong>Conclusions: </strong>Anxiety is a common comorbidity among patients with asthma and it is associated with poorer disease control and a reduced quality of life.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1075-1079"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of obstructive sleep apnea among patients with bronchial asthma.","authors":"S Madhan, Antonious Maria Selvam, Praveen Radhakrishnan, Yuvarajan Sivagnaname, Arivarasan Barathi","doi":"10.1080/02770903.2026.2654590","DOIUrl":"10.1080/02770903.2026.2654590","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine the prevalence, severity, and predictors of OSA among patients with bronchial asthma.</p><p><strong>Methods: </strong>This hospital-based cross-sectional analytical study was conducted over 18 months among 90 adult BA patients diagnosed according to GINA 2019 guidelines. Data collection included a structured questionnaire, clinical examination, spirometry, and the Epworth Sleepiness Scale (ESS). Patients with ESS >10 underwent overnight polysomnography, and OSA severity was assessed using the Apnea-Hypopnea Index (AHI). Bivariate and multivariable analyses were performed to identify predictors of OSA.</p><p><strong>Results: </strong>OSA was diagnosed in 30 of 90 patients (33.3%). OSA severity was mild in 11 (36.7%), moderate in 15 (50.0%), and severe in 4 (13.3%) patients, with 63.3% having moderate-to-severe disease. Excessive daytime sleepiness (ESS >10) was present in 30.0% of participants, all of whom had PSG-confirmed OSA. AHI showed strong positive correlations with ESS score (<i>r</i> = 0.855), asthma severity (<i>r</i> = 0.641), and asthma duration (<i>r</i> = 0.516) (all <i>p</i> < 0.001). On multivariable analysis, GERD (aOR = 4.62; 95% CI: 1.05-20.33; <i>p</i> = 0.043) and severe asthma (aOR = 52.20; 95% CI: 2.92-932.41; <i>p</i> = 0.007) independently predicted OSA.</p><p><strong>Conclusion: </strong>OSA is highly prevalent among patients with bronchial asthma, particularly those with severe disease and GERD. Routine sleep assessment may aid in comprehensive asthma management. Larger longitudinal studies are needed to confirm these findings.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1152-1160"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating Respiratory Emergencies in Children Study (T-RECS): a pilot trial of prehospital treatment for life-threatening pediatric asthma.","authors":"Matt Hansen, Kammy Jacobsen, Spencer Freeman, John Studnek, Doug Swanson, Christine Ranjit, Rachel Crady, Susan J Burnett, Brian Clemency, Sarah Becker, Graham Brant-Zawadzki, Jessica Jung, Bradley J Barney","doi":"10.1080/02770903.2026.2654585","DOIUrl":"10.1080/02770903.2026.2654585","url":null,"abstract":"<p><strong>Objectives: </strong>The Treating Respiratory Emergencies in Children Study (T-RECS) pilot study evaluated the feasibility of a prehospital treatment protocol for life-threatening pediatric asthma, including combined albuterol/ipratropium (DuoNeb) and dexamethasone with a checklist, to inform a future trial.</p><p><strong>Methods: </strong>Prospective, before-and-after study across three US EMS agencies (January 2024-February 2025). We enrolled patients aged 2-17 with severe asthma exacerbations who met specific criteria. The intervention phase introduced the new protocol and checklist. The primary outcome was the hospital admission status collection rate. Secondary outcomes included NIH PROMIS asthma impact score collection, hospital-free days, and ICU-free days. Implementation outcomes were assessed using the RE-AIM framework, including reach, paramedic adoption, and protocol implementation. Paramedic surveys assessed protocol and checklist acceptability. The study was registered on clinicaltrials.gov on 8/10/23 (NCT06074185).</p><p><strong>Results: </strong>The study screened 302 patients and enrolled 43. Hospital admission status was collected for 58% of enrolled patients. There was an observed increase in the use of albuterol/ipratropium (50% to 78.1%) and dexamethasone (41.7% to 65.6%) in the post-intervention phase, with an increase in the combined use of both (16.7% to 53.1%). Paramedic surveys (28% response rate) indicated the protocol was generally easy to follow, and the checklist was helpful. Challenges included time constraints and specific eligibility criteria.</p><p><strong>Conclusions: </strong>This pilot trial evaluated the feasibility and acceptability of implementing a prehospital protocol for severe pediatric asthma. While hospital data collection needs to be improved, these findings provide important considerations for a larger trial to evaluate the impact of this intervention on patient outcomes.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1143-1151"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}