Journal of Asthma最新文献

{"title":"Asthma causally affects the brain cortical structure: a Mendelian randomization study.","authors":"Tingting Fu, Xiao Fu, Jing Gao, Shilong Zhao, Chunling Hu, Junlu Li, Lihua Xing","doi":"10.1080/02770903.2025.2493123","DOIUrl":"10.1080/02770903.2025.2493123","url":null,"abstract":"<p><strong>Objective: </strong>The potential causal relationship between asthma and brain structures remains uncertain. We performed a two-sample Mendelian randomization to investigate the causal effects of various asthma phenotypes - unspecified asthma, moderate-to-severe asthma, childhood-onset asthma, and adult-onset asthma (AOA) - on cerebral cortex structure.</p><p><strong>Methods: </strong>We utilized phenotype data derived from genome-wide association studies (GWASs). The ENIGMA Consortium GWAS provided outcome variables for surface area (SA) and thickness across the whole brain and 34 region-specific areas of the cerebral cortex. Using the inverse variance-weighted method as our primary estimation approach, we employed several techniques, including Cochran's <i>Q</i> statistic, the MR-PRESSO global test, MR-Egger, and weighted median, to assess heterogeneity and pleiotropy, thereby ensuring the robustness of our findings. Additionally, we conducted enrichment analyses of gene sets with causal effects on cortical structure and applied bioinformatics techniques to construct interaction networks and identify hub nodes.</p><p><strong>Results: </strong>At the global level, AOA was associated with a significant reduction in full cortical SA (<i>β</i> = -58.49 mm², <i>p</i> = 0.017). In regional analyses, moderate-to-severe asthma exhibited a more pronounced impact on the cerebral cortex compared to other phenotypes. Enrichment analysis revealed that pathways implicated in brain morphology among asthma patients were primarily linked to immune and inflammation-driven pathways.</p><p><strong>Conclusions: </strong>Our findings provide new evidence supporting a causal relationship between asthma and alterations in cortical structure, offering potential explanations for cognitive and psychiatric impairments observed in individual post-asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1499-1511"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-frequency percussive ventilation as a lifesaving intervention in a pediatric case of life-threatening asthma: a case report and literature review.","authors":"Lanah Almatroud, John S Rerucha, Waseem Ostwani","doi":"10.1080/02770903.2025.2495723","DOIUrl":"10.1080/02770903.2025.2495723","url":null,"abstract":"<p><strong>Introduction: </strong>Severe acute asthma exacerbation requiring mechanical ventilation, referred to as life-threatening asthma, presents significant challenges due to elevated airway resistance, dynamic hyperinflation, and impaired gas exchange. Conventional mechanical ventilation may be insufficient in these cases, necessitating alternative strategies. High-frequency percussive ventilation (HFPV) offers a promising approach by combining improved oxygenation and ventilation with effective secretion clearance.</p><p><strong>Case study: </strong>An 11-year-old male with a history of asthma and eczema presented to the emergency department in respiratory failure with profound hypercarbia. Life-threatening asthma with cardiopulmonary arrest led to endotracheal intubation and initiation of mechanical ventilation. Despite the use of conventional settings, oxygen saturation remained critically low, and air trapping persisted. The patient was transitioned to HFPV <i>via</i> a VDR^®-4 ventilator.</p><p><strong>Results: </strong>Arterial blood gases demonstrated rapid improvement within 2 hours (from pH 6.7, pCO₂ >120 mmHg to pH 7.169, pCO₂ 77.2 mmHg). After 29 hours on HFPV, the patient was transitioned to conventional ventilation, followed by tracheal extubation to high-flow nasal cannula. The patient was discharged home within 72 hours with optimized asthma management.</p><p><strong>Conclusion: </strong>This case demonstrates the potential efficacy of HFPV in managing life-threatening pediatric asthma, achieving rapid stabilization without the use of neuromuscular blockade. Further prospective studies are needed to evaluate HFPV's potential as a rescue therapy in both specialized and non-specialized settings.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1644-1650"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting prolonged hospitalization in asthma patients: model development and external validation.","authors":"Xinkai Ma, Peiqi Li, Yupeng Li, Yanqing Xing, Zhen Ma, Chuangchuan Dong, Liting Feng, Rujie Huo, Fei Hu, Yanting Dong, Jie Chen, Jiali Zhang, Xinrui Tian","doi":"10.1080/02770903.2025.2500081","DOIUrl":"10.1080/02770903.2025.2500081","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to develop and validate a machine learning (ML) model to predict prolonged hospitalization in asthma patients.</p><p><strong>Patients and methods: </strong>This retrospective cohort study included patients with asthma as the primary diagnosis. We randomly divided 2820 asthma patients from Beth Israel Deaconess Medical Center into a training set and an internal validation set (in an 8:2 ratio), and used 1714 asthma patients from 208 other hospitals in the United States as an external validation cohort. Prolonged hospitalization was the primary outcome. Feature selection was conducted using LASSO regression, univariate logistic regression, and multivariate logistic regression analyses. Nine ML algorithms were employed to develop predictive models.</p><p><strong>Results: </strong>Based on discrimination, calibration, and clinical utility, the Extreme Gradient Boosting (XGBoost) model demonstrated the best overall performance. The nine most important predictors in the model were age, oxygen saturation (SpO2), red blood cell count, hemoglobin count, comorbid pneumonia, chronic obstructive pulmonary disease (COPD), congestive heart failure, anxiety, and use of invasive mechanical ventilation. The XGBoost model achieved an area under the receiver operating characteristic curve (AUC) of 0.829 and a Cohen's Kappa value of 0.439 in the internal validation set, and an AUC of 0.745 and a Cohen's Kappa value of 0.315 in the external validation set. The decision curve analysis indicated good clinical utility of the model.</p><p><strong>Conclusions: </strong>The XGBoost model can effectively predict prolonged hospitalization in asthma patients.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1616-1626"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking anemia to asthma: maternal, childhood and adult perspectives from a meta-analysis of 20 studies.","authors":"Kaiwen Zheng, Xiang Wang","doi":"10.1080/02770903.2025.2499837","DOIUrl":"10.1080/02770903.2025.2499837","url":null,"abstract":"<p><strong>Background: </strong>Anemia has been implicated as a potential risk factor for asthma across different life stages, yet evidence remains inconsistent.</p><p><strong>Objective: </strong>This meta-analysis (CRD420251008733) aimed to evaluate the associations between maternal anemia and offspring asthma, childhood anemia and asthma, and adult anemia and asthma.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Web of Science, and Cochrane Library, identifying 20 observational studies. Study quality was assessed using the Newcastle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ) checklist. Heterogeneity, sensitivity, and publication bias were explored through subgroup analyses, sensitivity tests, and Egger's test. Meta-analysis performed using Stata 17.</p><p><strong>Results: </strong>Twenty studies involving over 4499364 participants were included. The results showed pooled OR for the association between anemia and asthma (OR = 1.55, 95% CI: 1.36-1.77). Maternal anemia during pregnancy was associated with a modest increase in offspring asthma risk (OR = 1.19, 95% CI: 1.02-1.38), adult anemia was also linked to asthma (OR = 1.94, 95% CI: 1.14-3.30). Childhood anemia showed a stronger association with asthma (OR = 2.22, 95% CI: 1.65-2.99), though Egger's test (<i>p</i> = 0.041) suggested publication bias, with an adjusted OR of 2.03 (95% CI: 1.51-2.74).</p><p><strong>Conclusions: </strong>Anemia is significantly associated with an increased risk of asthma, particularly in children. These findings suggest a potential role for anemia screening in asthma management.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1459-1471"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in asthma health literacy: a comparative analysis of ChatGPT versus Gemini.","authors":"Simon Høj, Vibeke Backer, Charlotte Suppli Ulrik, Torben Sigsgaard, Howraman Meteran","doi":"10.1080/02770903.2025.2495729","DOIUrl":"10.1080/02770903.2025.2495729","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a complex and heterogeneous chronic disease affecting over 300 million individuals worldwide. Despite advances in pharmacotherapy, poor disease control remains a major challenge, necessitating innovative approaches to patient education and self-management. Artificial intelligence driven chatbots, such as ChatGPT and Gemini, have the potential to enhance asthma care by providing real-time, evidence-based information. As asthma management moves toward personalized medicine, AI could support individualized education and treatment guidance. However, concerns remain regarding the accuracy and reliability of AI-generated medical content.</p><p><strong>Objective: </strong>This study evaluated the accuracy of ChatGPT (version 4.0) and Gemini (version 1.2) in providing asthma-related health information using the Patient-completed Asthma Knowledge Questionnaire, a validated asthma literacy tool.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in which both AI models answered 54 standardized asthma-related items. Responses were classified as correct or incorrect based on alignment with validated clinical knowledge. Accuracy was assessed using descriptive statistics, Cohen's kappa for inter-model agreement, and chi-square tests for comparative performance.</p><p><strong>Results: </strong>ChatGPT achieved an accuracy of 96.3% (52/54 correct; 95% CI: 87.5%-99.0%), while Gemini scored 92.6% (50/54 correct; 95% CI: 82.5%-97.1%), with no statistically significant difference (<i>p</i> = 0.67). Cohen's kappa demonstrated near-perfect agreement for ChatGPT (κ = 0.91) and strong agreement for Gemini (κ = 0.82).</p><p><strong>Conclusion: </strong>ChatGPT and Gemini demonstrated high accuracy in delivering asthma-related health information, supporting their potential as adjunct tools for patient education. AI models could potentially play a role in personalized asthma management by providing tailored treatment guidance and improving patient engagement.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1560-1566"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational risk factors for asthma exacerbation in adults: a five-year follow-up of the Norwegian Telemark study cohort.","authors":"Nikola Zivadinovic, Keson Jaioun, Geir Klepaker, Anthony Wagstaff, Kjell Torén, Paul K Henneberger, Johny Kongerud, Regine Abrahamsen, Anne Kristin Møller Fell","doi":"10.1080/02770903.2025.2500077","DOIUrl":"10.1080/02770903.2025.2500077","url":null,"abstract":"<p><strong>Objectives: </strong>Asthma exacerbation due to occupational exposure is highly prevalent among adults with asthma. This study assessed the association between occupational risk factors and asthma exacerbation and estimated the impact of asthma exacerbations on job change, sick leave and work ability.</p><p><strong>Methods: </strong>In a prospective study of respiratory health in Telemark, Norway, 1857 adult participants with physician-diagnosed asthma were invited to participate in a follow-up survey. Among those who responded, 740 were found eligible for this study. Participants were categorized into overall, mild, and severe asthma exacerbation groups based on self-reports of hospitalization, doctor or emergency visits for breathing difficulties, or increased or new use of lung medications. Logistic regression, adjusted for age, sex, and smoking, was used to assess associations between self-reported asthma exacerbation and exposure to VGDF, job exposure matrix (N-JEM) data, job change, sick leave, and work ability.</p><p><strong>Results: </strong>Asthma exacerbation occurred in 140 (19%) responders; 83 had mild exacerbations and 57 severe exacerbations. Severe exacerbation was associated with daily VGDF exposure (OR 2.57, 95% CI 1.15-5.78) and accidental peak exposure to irritants (OR 4.62, 95% CI 1.13-18.85). Both overall and severe exacerbation were associated with job changes (OR 5.40, 1.26-5.65; OR 3.06, 1.16-8.07), sick leave (OR 1.94, 1.33-2.85; OR 2.78, 1.57-4.92), and reduced work ability (OR 1.61, 1.04-2.49; OR 2.17, 1.18-3.98).</p><p><strong>Conclusion: </strong>Asthma exacerbation was associated with VGDF exposure and some N-JEM occupational exposures. Reducing workplace exposure may decrease job-change, sick leave, and improve work ability in individuals with asthma exacerbation.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1608-1615"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing gaps in asthma management during childbearing age and pregnancy: insights from a survey of Italian physicians and patients.","authors":"Manuela Latorre, Cristina Cardini, Oliviero Rossi, Enrico Heffler, Diego Bagnasco, Gianenrico Senna, Gabriella Guarnieri, Francesco Blasi, Giorgio Walter Canonica, Pierluigi Paggiaro","doi":"10.1080/02770903.2025.2494222","DOIUrl":"10.1080/02770903.2025.2494222","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a common condition among women of childbearing age, requiring careful management, particularly during pregnancy. Despite existing guidelines, significant gaps remain in asthma management during pregnancy, notably for women with moderate-to-severe asthma.</p><p><strong>Aim: </strong>This study aimed to explore the awareness, limitations, and challenges of asthma management during childbearing age and pregnancy from both asthmatic women (AW) and physician perspectives in Italy. Additionally, it sought to identify unmet needs and collect real-life experiences from Italian centers specialized in severe asthma care.</p><p><strong>Methods: </strong>An anonymous online survey was disseminated through scientific networks and patient associations. Separate questionnaires were developed for doctors and AW by a task force of specialists.</p><p><strong>Results: </strong>76 doctors and 54 AW completed the survey, with 70% of AW reporting moderate-to-severe asthma. While most physicians had experience managing asthma in pregnancy, 40% lacked systematic collaboration with gynecologists recognizing the need for integrated care. Despite guidelines supporting asthma medication continuity, 60% of doctors reported discontinuing treatments due to perceived risks. However, surveyed AW generally expressed greater confidence in medication safety. Physicians and AW highlighted the lack of pre-pregnancy counseling, with 55% of AW reporting they had never discussed pregnancy plans when starting asthma treatment. Both groups emphasized the need for improved interdisciplinary collaboration and structured asthma care pathways during pregnancy.</p><p><strong>Conclusions: </strong>This study reveals significant gaps in asthma management for women of childbearing age and during pregnancy, especially those with moderate-to-severe asthma. Improving outcomes requires better education for patients and healthcare providers, along with a structured multidisciplinary network.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1537-1546"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of tezepelumab therapy on perceived asthma triggers: a multicenter real-life study.","authors":"Andrea Portacci, Giulia Scioscia, Silvano Dragonieri, Maria Aliani, Ernesto Lulaj, Francesca Montagnolo, Pietro Magaletti, Piera Soccio, Luciana Salerno, Donato Lacedonia, Giovanna Elisiana Carpagnano","doi":"10.1080/02770903.2025.2495725","DOIUrl":"10.1080/02770903.2025.2495725","url":null,"abstract":"<p><strong>Objective: </strong>Asthma exacerbations are often triggered by factors such as respiratory infections, allergens, exercise, and airway irritants, significantly affecting patients' respiratory symptoms and quality of life. Effective management of triggers is crucial in severe asthma care. Tezepelumab, an anti-thymic stromal lymphopoietin (TSLP) monoclonal antibody, can effectively reduce severe asthma exacerbations and symptoms burden. However, its impact on patients' perception of trigger-related symptoms remains underexplored.</p><p><strong>Methods: </strong>We conducted an observational, multicenter study involving 30 severe asthma patients starting tezepelumab 210 mg every 4 wk. Asthma triggers were assessed with the Asthma Triggers Inventory (ATI), while respiratory symptoms and HRQoL were evaluated using the Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), and Asthma Quality of Life Questionnaire (AQLQ). Data were collected at baseline (T0) and after 3 months of treatment (T3).</p><p><strong>Results: </strong>At T3, patients demonstrated a significant reduction in the impact of asthma triggers as well as improvements in the perception of triggers effects on HRQoL. Specific improvements were observed in the \"air pollution/irritants\" and \"infection\" domains of the ATI. Correlation analysis revealed a significant association between ATI and AQLQ changes over time.</p><p><strong>Conclusion: </strong>Tezepelumab positively impacts patients' perception of asthma triggers and their HRQoL, supporting its role in managing triggers hypersensitivity as a treatable trait in severe asthma. Further research is warranted to investigate underlying mechanisms and long-term effects.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1567-1574"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-driven airway eosinophilia and neutrophilia in asthma.","authors":"Joseph Zouein, Loretta G Que, Jennifer L Ingram","doi":"10.1080/02770903.2025.2505464","DOIUrl":"10.1080/02770903.2025.2505464","url":null,"abstract":"<p><strong>Objective: </strong>Asthma patients with comorbid obesity tend to have more severe, difficult-to-control asthma than lean asthma patients. This increase in asthma severity may be due, in part, to obesity-related adipokines, such as leptin, which contribute to airway hyperresponsiveness, sustained subclinical chronic inflammation, and treatment resistance. This narrative literature review aims to elucidate the differences in airway eosinophilia and neutrophilia profiles between asthma patients with and without obesity.</p><p><strong>Methods: </strong>A PubMed search of full journal articles published between 1992 and 2024 was performed in April 2024 using the terms \"asthma\", \"tissue eosinophilia\" and \"obesity\" combined with the Boolean operator \"AND\". Articles detailing airway tissue eosinophilia and neutrophilia in asthma patients or mice were included. Only articles in English were included.</p><p><strong>Results: </strong>To date, several studies have reported increased airway tissue eosinophilia in obese mouse asthma models (four studies) and in asthma patients with obesity (three studies). Airway tissue eosinophilia in asthma patients with obesity is driven by altered and elevated levels of adipokines, pro-inflammatory cytokines, and eosinophil-stimulating chemokines such as eotaxin. Leptin and eotaxin levels are increased in asthma with obesity and contribute to enhanced eosinophil recruitment, migration, adhesion to airway smooth muscles and fibroblasts, and reduced apoptosis.</p><p><strong>Conclusions: </strong>Airway tissue eosinophilia is an important feature of obesity-associated asthma. Airway tissue eosinophilia is mainly driven by obesity-related homeostatic changes. These increased airway tissue eosinophils contribute to a more severe disease.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1472-1482"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Tailoring of a Peer-Administered Asthma Management Intervention for Urban Latino Middle School Children.","authors":"Daphne Koinis-Mitchell, Christina D'Angelo, Maria Teresa Coutinho, Sheryl J Kopel, Rebecca Noga, Heather Yoho, Luis Guzman, Sumera S Subzwari, Elizabeth L McQuaid, Ligia Chavez, Jean-Marie Bruzzese, Anna J Yeo, Glorisa Canino","doi":"10.1080/02770903.2025.2539807","DOIUrl":"https://doi.org/10.1080/02770903.2025.2539807","url":null,"abstract":"<p><p><b>Objective</b>: Children from Latino backgrounds face unique challenges in managing asthma. Barriers are compounded when children live in urban settings and are exposed to urban stressors (e.g., barriers to medication use, neighborhood stress). Asthma management in schools is often directly implicated. This study aims to address these gaps in care by developing a 4-session, peer-facilitated, culturally tailored asthma self-management group intervention in urban public-school settings. <b>Methods</b>: We developed and tested the ASMAS (<u>A</u>sthma <u>S</u>elf-<u>Ma</u>nagement in <u>S</u>chools) intervention, utilizing an iterative process guided by previous work and theoretical models. Feedback from focus groups was used to further tailor ASMAS. We enrolled 81 middle school students in a cross-site pilot randomized controlled trial (RCT) to evaluate the efficacy of ASMAS compared both to Attention Control and No-Treatment Control conditions. Outcomes included asthma control, asthma-related sleep disruption, school absences, asthma self-efficacy, and availability of rescue inhaler and asthma action plan (AAP) at school. <b>Results</b>: Compared to Attention Control participants, youth who received ASMAS had improved asthma outcomes over time (baseline to end-of-treatment) including asthma control (t = 2.1, <i>p</i><.05, d=.4, M_diff=1.5), asthma-related sleep disruptions (t=-.24, <i>p</i> <.05, d=-.4, M_diff=-3.6), school absences (d=-.2), asthma management self-efficacy (t = 2.3, <i>p</i> <.05, d=.4, M_diff=0.3) and rates of AAP (t = 1.8, <i>p</i> =.06; d=.3, M_diff=20%) and rescue inhalers availability (t = 2.0, <i>p</i> <.01, d=.7, M_diff=23%). Similar patterns were maintained at 4-month follow-up. <b>Conclusions</b>: Results demonstrate ASMAS' feasibility and highlight the potential benefits of the tailored asthma intervention. A full-scale RCT to evaluate ASMAS' effectiveness, implementation, and sustainability is warranted.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}