Nikola Zivadinovic, Keson Jaioun, Geir Klepaker, Anthony Wagstaff, Kjell Torén, Paul K Henneberger, Johny Kongerud, Regine Abrahamsen, Anne Kristin Møller Fell
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Participants were categorized into overall, mild, and severe asthma exacerbation groups based on self-reports of hospitalization, doctor or emergency visits for breathing difficulties, or increased or new use of lung medications. Logistic regression, adjusted for age, sex, and smoking, was used to assess associations between self-reported asthma exacerbation and exposure to VGDF, job exposure matrix (N-JEM) data, job change, sick leave, and work ability.</p><p><strong>Results: </strong>Asthma exacerbation occurred in 140 (19%) responders; 83 had mild exacerbations and 57 severe exacerbations. Severe exacerbation was associated with daily VGDF exposure (OR 2.57, 95% CI 1.15-5.78) and accidental peak exposure to irritants (OR 4.62, 95% CI 1.13-18.85). Both overall and severe exacerbation were associated with job changes (OR 5.40, 1.26-5.65; OR 3.06, 1.16-8.07), sick leave (OR 1.94, 1.33-2.85; OR 2.78, 1.57-4.92), and reduced work ability (OR 1.61, 1.04-2.49; OR 2.17, 1.18-3.98).</p><p><strong>Conclusion: </strong>Asthma exacerbation was associated with VGDF exposure and some N-JEM occupational exposures. Reducing workplace exposure may decrease job-change, sick leave, and improve work ability in individuals with asthma exacerbation.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1608-1615"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Occupational risk factors for asthma exacerbation in adults: a five-year follow-up of the Norwegian Telemark study cohort.\",\"authors\":\"Nikola Zivadinovic, Keson Jaioun, Geir Klepaker, Anthony Wagstaff, Kjell Torén, Paul K Henneberger, Johny Kongerud, Regine Abrahamsen, Anne Kristin Møller Fell\",\"doi\":\"10.1080/02770903.2025.2500077\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Asthma exacerbation due to occupational exposure is highly prevalent among adults with asthma. This study assessed the association between occupational risk factors and asthma exacerbation and estimated the impact of asthma exacerbations on job change, sick leave and work ability.</p><p><strong>Methods: </strong>In a prospective study of respiratory health in Telemark, Norway, 1857 adult participants with physician-diagnosed asthma were invited to participate in a follow-up survey. Among those who responded, 740 were found eligible for this study. Participants were categorized into overall, mild, and severe asthma exacerbation groups based on self-reports of hospitalization, doctor or emergency visits for breathing difficulties, or increased or new use of lung medications. Logistic regression, adjusted for age, sex, and smoking, was used to assess associations between self-reported asthma exacerbation and exposure to VGDF, job exposure matrix (N-JEM) data, job change, sick leave, and work ability.</p><p><strong>Results: </strong>Asthma exacerbation occurred in 140 (19%) responders; 83 had mild exacerbations and 57 severe exacerbations. Severe exacerbation was associated with daily VGDF exposure (OR 2.57, 95% CI 1.15-5.78) and accidental peak exposure to irritants (OR 4.62, 95% CI 1.13-18.85). Both overall and severe exacerbation were associated with job changes (OR 5.40, 1.26-5.65; OR 3.06, 1.16-8.07), sick leave (OR 1.94, 1.33-2.85; OR 2.78, 1.57-4.92), and reduced work ability (OR 1.61, 1.04-2.49; OR 2.17, 1.18-3.98).</p><p><strong>Conclusion: </strong>Asthma exacerbation was associated with VGDF exposure and some N-JEM occupational exposures. 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引用次数: 0
摘要
目的:职业暴露引起的哮喘加重在成人哮喘患者中非常普遍。本研究评估职业危险因素与哮喘加重的关系,并评估哮喘加重对工作变动、病假及工作能力的影响。方法:在挪威Telemark的一项前瞻性呼吸健康研究中,邀请1857名医生诊断为哮喘的成年参与者参加随访调查。在应答者中,有740人符合本研究的条件。参与者根据自我报告的住院情况、因呼吸困难而就诊的医生或急诊情况、增加或新使用的肺部药物情况,被分为全面、轻度和重度哮喘加重组。采用Logistic回归,调整年龄、性别和吸烟,评估自我报告的哮喘恶化与暴露于VGDF、工作暴露矩阵(N-JEM)数据、工作变化、病假和工作能力之间的关系。结果:140例(19%)应答者发生哮喘加重;轻度加重83例,重度加重57例。严重恶化与每日暴露于VGDF (OR 2.57, 95% CI 1.15-5.78)和意外峰值暴露于刺激物(OR 4.62, 95% CI 1.13-18.85)相关。总体加重和严重加重均与工作变动相关(OR 5.40, 1.26-5.65;OR 3.06, 1.16-8.07),病假(OR 1.94, 1.33-2.85;OR 2.78, 1.57-4.92),工作能力降低(OR 1.61, 1.04-2.49;或2.17,1.18-3.98)。结论:哮喘加重与VGDF暴露和部分N-JEM职业暴露有关。减少工作场所暴露可减少哮喘加重患者的换工作、病假和提高工作能力。
Occupational risk factors for asthma exacerbation in adults: a five-year follow-up of the Norwegian Telemark study cohort.
Objectives: Asthma exacerbation due to occupational exposure is highly prevalent among adults with asthma. This study assessed the association between occupational risk factors and asthma exacerbation and estimated the impact of asthma exacerbations on job change, sick leave and work ability.
Methods: In a prospective study of respiratory health in Telemark, Norway, 1857 adult participants with physician-diagnosed asthma were invited to participate in a follow-up survey. Among those who responded, 740 were found eligible for this study. Participants were categorized into overall, mild, and severe asthma exacerbation groups based on self-reports of hospitalization, doctor or emergency visits for breathing difficulties, or increased or new use of lung medications. Logistic regression, adjusted for age, sex, and smoking, was used to assess associations between self-reported asthma exacerbation and exposure to VGDF, job exposure matrix (N-JEM) data, job change, sick leave, and work ability.
Results: Asthma exacerbation occurred in 140 (19%) responders; 83 had mild exacerbations and 57 severe exacerbations. Severe exacerbation was associated with daily VGDF exposure (OR 2.57, 95% CI 1.15-5.78) and accidental peak exposure to irritants (OR 4.62, 95% CI 1.13-18.85). Both overall and severe exacerbation were associated with job changes (OR 5.40, 1.26-5.65; OR 3.06, 1.16-8.07), sick leave (OR 1.94, 1.33-2.85; OR 2.78, 1.57-4.92), and reduced work ability (OR 1.61, 1.04-2.49; OR 2.17, 1.18-3.98).
Conclusion: Asthma exacerbation was associated with VGDF exposure and some N-JEM occupational exposures. Reducing workplace exposure may decrease job-change, sick leave, and improve work ability in individuals with asthma exacerbation.
期刊介绍:
Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.