Journal of Asthma最新文献

{"title":"Patient perspectives on the use of oral corticosteroids in asthma.","authors":"Tonya Winders, Monica Fletcher, John Oppenheimer, Peter Howarth, Zeina Eid Antoun, Thys van der Molen, Liam G Heaney, Mike Thomas","doi":"10.1080/02770903.2025.2466183","DOIUrl":"10.1080/02770903.2025.2466183","url":null,"abstract":"<p><strong>Objective: </strong>Oral corticosteroids (OCS) are used to treat uncontrolled asthma, either as short rescue courses of treatment for severe disease exacerbations, or as long-term maintenance therapy in addition to other controller medications. Although the adverse events (AEs) associated with OCS are well understood by healthcare professionals (HCPs), the patient's perspective may be underappreciated. This review discusses the patient perspective on OCS use.</p><p><strong>Data sources: </strong>A PubMed literature review was performed.</p><p><strong>Study selection: </strong>Articles were selected to include those primarily containing data on patient perspectives on OCS use in asthma or other airway diseases, including qualitative and quantitative studies. Articles including only clinical data and those primarily focused on another indication were excluded. Additional articles meeting the criteria were permitted based on author knowledge and the bibliographies of systematic reviews on other topics.</p><p><strong>Results: </strong>A total of 6066 articles were identified from the PubMed search; 111 were assessed more closely for eligibility. Fourteen articles were eventually selected by the reviewers for inclusion and confirmed by all authors. Several key themes were identified: (1) Key AEs were prominently reported by patients (including weight gain, skin thinning, known osteoporosis/osteopenia, and sleep/mood disturbances); (2) Impact of OCS on day-to-day lives; (3) Patient perceptions of OCS; (4) Effect of perceptions on treatment adherence.</p><p><strong>Conclusion: </strong>HCPs should consider the impact that OCS have on their patients' wellbeing, including short courses. It is essential for HCPs to discuss the short and long-term risks of OCS with patients prior to initiation of treatment and consider alternatives for patients on long-term OCS.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationships between allergic diseases and significant declines in lung function: a multivariable Mendelian randomization study.","authors":"Jiannan Lin, Xiaoyu Zhao, Shuwen Lu","doi":"10.1080/02770903.2025.2472359","DOIUrl":"https://doi.org/10.1080/02770903.2025.2472359","url":null,"abstract":"<p><strong>Background: </strong>Asthma and other allergic diseases are increasing globally each year, with some patients experiencing the co-occurrence of two or more conditions, significantly impacting their quality of life. While these diseases may share certain immune mechanisms, the independent causal relationships between them and lung function remain unclear.</p><p><strong>Objective: </strong>This study aims to investigate the independent and interactive effects of allergic asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis on significant declines in lung function. By elucidating the potential causal relationships between these allergic diseases and reduced lung function, we hope to provide valuable scientific evidence for managing asthma patients who are co-morbid with multiple allergic conditions.</p><p><strong>Methods: </strong>In this study, we conducted Mendelian randomization (MR) analysis using data from the FinnGen database and the UK Biobank. We rigorously selected instrumental variables (IVs) based on established criteria and employed both univariable and multivariable MR approaches to investigate the relationship between various allergic diseases and significant declines in lung function.</p><p><strong>Results: </strong>In univariable MR analysis, the inverse variance-weighted (IVW) method or the weighted median approach indicated a causal relationship between allergic conjunctivitis, atopic dermatitis, and allergic asthma with significant declines in lung function. However, in multivariable MR analysis, the independent effects of atopic dermatitis and allergic conjunctivitis on lung function were no longer significant. Only allergic asthma continued to show a significant causal relationship with decreased lung function (OR [95%CI]: 1.019 [1.008-1.030], <i>p</i> < .001).</p><p><strong>Conclusions: </strong>This study suggests that while atopic dermatitis and allergic conjunctivitis may indirectly affect lung function and lead to significant declines, their independent effects are not notable when asthma is well-controlled. Therefore, clinicians should recognize that acute exacerbations of allergic diseases are unlikely to be the primary reason for significant declines in lung function among asthma patients with multiple allergic conditions, provided that their asthma is well-managed.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual role of mucosal-associated invariant T cells (MAIT) in asthma.","authors":"M Asghar Pasha, Rawaa Alnabulsi, Aiden Wan, Russell J Hopp, Qi Yang","doi":"10.1080/02770903.2025.2469319","DOIUrl":"10.1080/02770903.2025.2469319","url":null,"abstract":"<p><strong>Objective: </strong>Mucosal-associated invariant T cells (MAIT) are the predominant type of innate-like T cells in humans, and they represent a unique subset of microbiota-dependent invariant T cells. This Commentary reviews recent clinical studies and animal model research elucidating the multifaceted roles of MAIT cells in asthma.</p><p><strong>Method: </strong>A literature search was performed using PubMed and Google Scholar, and covered the period from 1960 to 2024. The search yielded more than 50 articles, and only essential original research articles and selected review articles were evaluated.</p><p><strong>Results: </strong>Recent studies indicate that MAIT cell-derived effector molecules may play dual roles in asthma and allergic airway inflammation. While MAIT cells can produce the anti-inflammatory enzyme IL4I1 and the Th1 cytokine IFN-γ to repress allergic airway inflammation and airway hyperresponsiveness (AHR), they may also secrete IL-17. Which induces neutrophil infiltration and exacerbates AHR. In addition, some clinical studies from the literature search revealed a negative association between MAIT cell abundance and asthma. Regarding allergic airway inflammation, mouse model studies suggested that MAIT cells may play a protective role.</p><p><strong>Conclusion: </strong>These findings raise critical questions as to whether MAIT cells are friend or foe in asthma, and whether distinct subsets of MAIT cells play different roles in allergic airway inflammation. Further studies are needed to better understand the implication of MAIT cells in asthma pathogenesis, particularly in patients with severe asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human blood metabolites and obesity-related asthma-a Mendelian randomization study.","authors":"Xinghui Li, Yunzhi Xiao, Yaoyao Chen, Guansheng Zeng, Lichang Chen","doi":"10.1080/02770903.2025.2469313","DOIUrl":"10.1080/02770903.2025.2469313","url":null,"abstract":"<p><strong>Purpose: </strong>Obesity-related asthma poses serious health problems. Blood metabolite concentrations play crucial roles in its development, but the association with obesity-related asthma risk is unclear. This study aimed to explore the causal effect of blood metabolite levels on this risk.</p><p><strong>Patients and methods: </strong>Using data from the 2023 FinnGen study, which included 345,200 subjects, with 10,306 patients having obesity-associated asthma, we conducted a two-sample Mendelian randomization (MR) analysis. We assessed the causal relationship between 1400 blood metabolites and the risk of developing obesity-associated asthma. The inverse-variance weighting (IVW) method was used to estimate the causal link, with additional tests for heterogeneity and pleiotropy to ensure robustness.</p><p><strong>Results: </strong>The forward MR results showed that 71 metabolites were associated with the risk of developing obesity-related asthma; 57 were previously identified, and 14 were new. Among the known metabolites, 29 were linked to an increased risk, and 28 to a decreased risk. Reverse-MR results identified four metabolites related to the risk of obesity-related asthma.</p><p><strong>Conclusion: </strong>The ratio of proline to trans-4-hydroxyproline and branched chain 14:0 dicarboxylic acid are negatively associated with the risk, while serum concentrations of X-25810 and N-acetyl-L-alanine are positively associated with the risk.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long non-coding RNA AK007111 mediates mast cells apoptosis via targeting of protein MOAP1.","authors":"Xiao Ma, Yingying Luo, Jiejing Xu, Feng Liu, Changdi Xu, Heng Tang","doi":"10.1080/02770903.2025.2463974","DOIUrl":"10.1080/02770903.2025.2463974","url":null,"abstract":"<p><strong>Background: </strong>Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes in a variety of diseases including asthma. In this study, we reported the identification of lncRNA-AK007111 as an essential modulator of mast cell apoptosis and investigated its potential mechanism.</p><p><strong>Methods: </strong>RNA-seq profiling and transcriptome sequencing technology were adopted to screen for differentially expressed genes. Transfection was done by small interfering RNAs (siRNAs) to down-regulate lncRNA-AK007111 and Modulator of apoptosis 1 (MOAP1). Starvation was used to induce apoptosis. The apoptotic rate was measured by flow cytometry. Western Blot was conducted to detect the expression of apoptosis-related proteins.</p><p><strong>Results: </strong>LncRNA-AK007111 was highly expressed in IgE/Ag-mediated activation of mast cells. Down-regulation of LncRNA-AK007111 promoted apoptosis of mast cells. Down-regulation of MOAP1 attenuated apoptosis in mast cells induced by the down-regulation of lncRNA-AK007111.</p><p><strong>Conclusion: </strong>LncRNA-AK007111 may be a potential regulator of mast cell apoptosis by interaction with MOAP1.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Evaluation of Wumei Pill (WP) for Nocturnal Asthma in Bmal1 Gene Knockout Mice.","authors":"Po Hu, Yili Tao, Yunwei Chen, Ying Yang, Bohan Wang, Wenxing Mei, Kejian Wang, Ye Wu","doi":"10.1080/02770903.2025.2469317","DOIUrl":"https://doi.org/10.1080/02770903.2025.2469317","url":null,"abstract":"<p><strong>Objective: </strong>Previous clinical studies have demonstrated that Wumei Pill (WP), a traditional Chinese medicine formula, can effectively alleviate nocturnal asthma-related anxiety and improve nighttime symptoms. The therapeutic mechanism of WP may involve regulation of inflammatory chemokines in peripheral blood. This mechanism is potentially linked to modulation of the circadian clock gene ARNT-like protein-1 (Bmal1), but precise pathways underlying this interaction remain unclear, requiring further investigation.</p><p><strong>Methods: </strong>Bmal1 knockout and wild-type mice were utilized to establish asthma models. Techniques such as flow cytometry, RT-PCR, and ELISA were employed to measure the levels of serum inflammatory mediators, specifically IFN-γ, CXCL16, I-TAC, and PARC. Furthermore, the pathological alterations in airway thickness were assessed. Additionally, we investigated the regulation of the Bmal1 gene and its influence on the circadian rhythm-related recruitment of leukocytes, as well as the expression patterns of downstream mediators.</p><p><strong>Results: </strong>Compared to the wild-type (WT) group, the model group showed significantly higher levels of CXCL16, I-TAC, and PARC (p < 0.05), as well as a notable decrease in IFN-γ expression. WP treatment effectively normalized the levels of these inflammatory factors in the model group, indicating a regulatory effect of WP on inflammatory chemokines.</p><p><strong>Conclusion: </strong>The knockout of the Bmal1 gene, a crucial regulator of circadian rhythms, disrupts the circadian expression of inflammatory chemokines. Treatment with WP modulated Bmal1 expression, influencing the release of these mediators, offering a promising strategy for managing nocturnal asthma. Notably, wild-type nocturnal asthma mice exhibited significantly better control of airway inflammation compared to their Bmal1-deficient counterparts, highlighting the importance of circadian regulation in the pathophysiology of asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry.","authors":"Zeynep Celebi Sozener, Ipek Kıvılcım Oguzulgen, Funda Seher Ozalp Ates, Ayse Baccioglu, Serap Argun Barıs, Dane Ediger, Fatma Esra Gunaydın, Can Sevinc, Ummuhan Seker, Bilge Yılmaz Kara, Sengul Beyaz, Dilsad Mungan, Omur Aydin, Derya Gokmen, Gozde Koycu Buhari, Bilun Gemicioglu, Ismet Bulut, Cihan Orcen, Secil Kepil Ozdemir, Metin Keren, Ebru Damadoglu, Tugce Yakut, Ayse Fusun Kalpaklioglu, Sumeyra Alan Yalim, Insu Yilmaz, Ilkay Koca Kalkan, Mehmet Atilla Uysal, Elif Yelda Ozgun Niksarlioglu, Ali Fuat Kalyoncu, Gul Karakaya, Muge Erbay, Sibel Nayci, Fatma Merve Tepetam, Asli Akkor Gelincik, Hulya Dirol, Ozlem Goksel, Selen Karaoglanoglu, Ferda Oner Erkekol, Sacide Rana Isik, Fusun Yildiz, Yasemin Yavuz, Dilek Karadogan, Nurgul Bozkurt, Ilknur Basyigit, Elif Yilmazel Ucar, Tuba Erdogan, Mehmet Polatli, Murat Turk, Leyla Pur, Zeynep Yegin Katran, Yonca Sekibag, Enes Furkan Aykac, Ozcan Gul, Ali Cengiz, Bulent Akkurt, Seyma Ozden, Semra Demir, Derya Unal, Ayse Feyza Aslan, Ali Can, Reyhan Gumusburun, Gulhan Bogatekin, Hatice Serpil Akten, Sinem Inan, Munevver Erdinc, Aliye Candan Ogus, Murat Kavas, Demet Polat Yulug, Mehmet Erdem Cakmak, Saltuk Bugra Kaya, Gulistan Alpagat, Eylem Sercan Ozgur, Oguz Uzun, Sule Tas Gulen, Gulseren Pekbak, Deniz Kizilirmak, Yavuz Havlucu, Halil Donmez, Bahar Arslan, Gulden Pacaci Cetin, Sadan Soyyigit, Gulden Pasaoglu Karakis, Adile Berna Dursun, Resat Kendirlinan, Ayse Bilge Ozturk, Gokcen Omeroglu Simsek, Oznur Abadoglu, Pamir Cerci, Taskin Yucel, Irfan Yorulmaz, Zahide Ciler Tezcaner, Emel Cadalli Tatar, Ahmet Emre Suslu, Serdar Ozer, Engin Dursun, Arzu Yorgancioglu, Gulfem Elif Celik","doi":"10.1080/02770903.2025.2466182","DOIUrl":"10.1080/02770903.2025.2466182","url":null,"abstract":"<p><strong>Objective: </strong>The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma.</p><p><strong>Methods: </strong>This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR). Clinical presentation, disease control, severity, and demographics of obese and non-obese (normal-weight, overweight) patients were compared.</p><p><strong>Results: </strong>The obesity rate in TAAR was 32.2% (<i>n</i> = 619/1919; 18-83 years; 527 F/92 M). Patients with asthma and obesity had higher rates of childhood obesity, longer symptom duration, later onset of asthma, and more severe asthma. These patients were more likely to be female, older, less educated, and live in rural areas. Patients with obesity had more scheduled visits and emergency visits compared with non-obese patients, but similar asthma control, oral corticosteroid use, hospitalizations, intensive care unit admissions, and unscheduled visits. They also had a higher frequency of T2-high but lower frequency of possible T2-low phenotypes compared with normal-weight asthmatics. The risk of severe asthma in patients with obesity was 6.04 times higher for allergic than non-allergic patients and 3.58 times higher for the T2-high phenotype than for possible T2-low phenotypes. A one-unit increase in the asthma control test reduced the risk of severe asthma by 22%.</p><p><strong>Conclusions: </strong>A good definition of this phenotype is important to ensure that appropriate treatment strategies are implemented to achieve the control goal. We also believe that prevention of childhood obesity is an effective and pivotal strategy to achieve the goal of asthma control.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and regional mortality trends in patients with asthma in the United States (1999-2020): a CDC WONDER analysis.","authors":"Sophia Ahmed, Muhammad Asfandyar Nadir, Areej Iftikhar, Hamza Ashraf, Mohammad Ashraf","doi":"10.1080/02770903.2025.2458519","DOIUrl":"https://doi.org/10.1080/02770903.2025.2458519","url":null,"abstract":"<p><strong>Objective: </strong>Around 7.7% of Americans have asthma, including 20.2 million adults and 4.6 million children. This study examines asthma mortality trends and disparities across U.S. demographic and geographic groups from 1999 to 2020.</p><p><strong>Methods: </strong>A retrospective analysis was conducted using the CDC WONDER database to examine asthma-related deaths in the U.S. from 1999 to 2020. Age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) per 100,000 were calculated. Trends and annual percent changes (APCs) were assessed overall and stratified by sex, race, region, and age.</p><p><strong>Results: </strong>From 1999 to 2020, the U.S. recorded 221 161 asthma-related deaths (AAMR: 3.07), mostly in medical facilities. Mortality declined from 1999 to 2018 (APC: -1.53%) but surged from 2018 to 2020 (APC: 28.63%). Females, NH Blacks, and NH American Indians had the highest mortality rates. Older adults (≥65) had the greatest burden, with younger groups showing notable increases post-2018. Rural areas and the West reported slightly higher rates than urban and other regions. Hawaii and the District of Columbia had the highest AAMRs, while Florida and Nevada had the lowest.</p><p><strong>Conclusion: </strong>Asthma-related mortality in the U.S. declined until 2018 but sharply increased from 2018 to 2020, with rises across all demographic groups, regions, and settings. Females, NH Blacks, and older adults consistently had higher mortality rates, while younger age groups showed recent alarming increases. Targeted interventions are urgently needed to address inequities and recent mortality surges.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of depression and asthma: a observational and Mendelian randomization study.","authors":"Shiyuan Guo, Yilong Lin, Junting Li, Yan Zheng, Xin Lan, Jiaojiao Chen, Shuying Li, Yingjie Feng, Songsong Wang","doi":"10.1080/02770903.2025.2463973","DOIUrl":"10.1080/02770903.2025.2463973","url":null,"abstract":"<p><strong>Background: </strong>Both depression and asthma have a significant impact on the quality of life for individuals. Studies have shown that patients with depression often experience comorbid asthma; however, the precise relationship between these two conditions remains unclear. The objective of this study is to investigate the causal relationship between depression and asthma.</p><p><strong>Methods: </strong>In a cross-sectional study, we utilized data from the National Health and Nutrition Examination Survey (NHANES) 2009-2014 and employed logistic regression to assess the correlation between depression and asthma. In the subsequent Mendelian randomization (MR) analysis, we selected single nucleotide polymorphisms (SNPs) closely linked to both depression and asthma as instrumental variables, based on summary data from genome-wide association studies (GWAS). The inverse variance weighted method (IVW) was then applied to ascertain the causal relationship between depression and asthma.</p><p><strong>Results: </strong>Based on the results of the cross-sectional study, it was found that the status of depression was significantly associated with a higher risk of asthma (OR = 2.15, 95%CI = 1.79 ∼ 2.59, <i>p</i> < 0.001). Furthermore, in the MR analysis, a causal relationship was further identified between depression, severe depression, and the increased incidence of asthma (OR = 1.11, 95%CI = 1.05 ∼ 1.18, <i>p</i> < 0.001), (OR = 1.01, 95%CI = 1.01 ∼ 1.02, <i>p</i> < 0.001); the results of the reverse MR analysis indicated no causal relationship between asthma and the increased incidence of depression and severe depression (OR = 1.01, 95%CI0.99 ∼ 1.03, <i>p</i> = 0.50), (OR = 1.07, 95%CI: 0.82 ∼ 1.40, <i>p</i> = 0.64).</p><p><strong>Conclusion: </strong>This study has revealed a causal relationship between depression and an increased risk of developing asthma, offering new insights for the clinical intervention of both asthma and depression.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of metalworking exposures on respiratory health: the role of fractional exhaled nitric oxide levels.","authors":"Hülya Doğan Tiryaki, Halim İşsever, Osman Küçükkelepçe, Adil Can Güngen, Nefise Şeker, Osman Kurt","doi":"10.1080/02770903.2025.2463966","DOIUrl":"10.1080/02770903.2025.2463966","url":null,"abstract":"<p><strong>Objective: </strong>The significance of measuring Fractional Exhaled Nitric Oxide (FeNO) has grown, particularly in monitoring respiratory diseases like asthma. FeNO levels indicate inflammation and a rise in response to respiratory irritants. This study investigates whether repeated exposure to irritants in metal casting and coating leads to respiratory inflammation and assesses the benefits of including FeNO measurement in periodic occupational health screenings.</p><p><strong>Methods: </strong>This cross-sectional study involved 99 workers aged 18-65 in the foundry and metal coating sectors in the İkitelli Organized Industrial Zone. The study group included 54 workers exposed to metal dust and fumes, while the control group comprised 45 workers in non-exposure roles (e.g. secretarial, assembly, packaging). Data were collected through face-to-face interviews, recording demographics, smoking habits, symptoms. FeNO levels were measured and analyzed with pulmonary function test parameters.</p><p><strong>Results: </strong>FeNO levels were significantly higher in the study group compared to the control group (<i>p</i> = 0.02). No significant relationships were found between FeNO levels and age, height, weight, BMI, waist circumference, years of work, or symptom presence, but a significant negative correlation was observed between FeNO levels and FEV1/FVC. Additionally, current smokers had significantly lower FeNO levels compared to those who had quit or never smoked (study, <i>p</i> = 0.014; control, <i>p</i> = 0.011).</p><p><strong>Conclusions: </strong>Monitoring FeNO levels in occupational health assessments may facilitate early intervention and preventive measures, protecting worker health. Incorporating FeNO measurement into periodic screenings could enhance occupational health practices.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}