Journal of Asthma最新文献

{"title":"Circulating inflammatory proteins as causal drivers and therapeutic targets in asthma: insights from genetic and pathway-based analyses.","authors":"Yiyan Miao, Haihua Chen, Qishu Wei, Kun Yan, Praise Audax Rukonge, Zhe Zhang, Guiping Yu","doi":"10.1080/02770903.2025.2555292","DOIUrl":"10.1080/02770903.2025.2555292","url":null,"abstract":"<p><strong>Objective: </strong>To identify circulating inflammatory proteins with potential causal roles in asthma development through integrated genetic and pathway-based analyses, and to evaluate their potential as therapeutic targets.</p><p><strong>Methods: </strong>We used genetically anchored instrumental variables from 180 protein quantitative trait loci (pQTLs) to assess the causal effects of 91 circulating inflammatory proteins on asthma risk, using large-scale GWAS datasets. Analytical robustness was evaluated through pleiotropy and heterogeneity testing. Functional enrichment and literature-based pathway analyses were performed to support biological plausibility and validate findings.</p><p><strong>Results: </strong>Four proteins showed significant causal effects on asthma: CCL19 and LIFR were protective (OR = 0.89 and 0.91, <i>p</i> ≤ 6.8E-03), while ARTN and IL6 were associated with increased risk (OR = 1.15 and 1.18, <i>p</i> ≤ 1.1E-04). We also identified reverse causal effects of asthma on 11 cytokines, including MMP10, TGFB1, IL33, and IL18R1. Most of these proteins were enriched in pathways related to cytokine signaling and immune response (<i>p</i> < 0.001). All identified proteins had prior literature support linking them to asthma or airway inflammation.</p><p><strong>Conclusions: </strong>Our findings highlight a subset of circulating inflammatory proteins that are likely causal in asthma pathogenesis and may serve as promising targets for therapeutic intervention. These results offer novel insights into the immunological mechanisms underlying asthma and support the utility of genetic causal inference in target prioritization.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary antioxidants: a challenge or an opportunity for asthma? Genetic insights from a Two-sample mendelian randomization study.","authors":"Xiaoqing Zhou, Yujie Zhou, Jialing Chen, Chen Chen, Ruilin Chen, Suqun Zheng, Zhen Wang, Linshui Zhou","doi":"10.1080/02770903.2025.2555297","DOIUrl":"10.1080/02770903.2025.2555297","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress is crucial in the immune response and airway inflammatory process associated with asthma. While the relationship between dietary antioxidants and asthma remains debated in observational studies, this study uses two-sample Mendelian randomization (MR) to explore a potential causal link.</p><p><strong>Methods: </strong>We acquired six distinct categories of absolute circulating antioxidants and five different types of metabolic circulating antioxidants from the most recent genome-wide association study data of the European population, including vitamin A (retinol), vitamin C (ascorbic acid), vitamin E (tocopherol), β-carotene, lycopene, and urate. The latest data regarding asthma was obtained from the FinnGen database. We utilized single nucleotide polymorphisms as instrumental variables to conduct five MR methods. To confirm the accuracy of the results, additional sensitivity analyses were performed to eliminate any potential confounding factors, such as heterogeneity and pleiotropy.</p><p><strong>Results: </strong>MR and sensitivity analyses revealed an association between circulating urate and asthma, suggesting a potential increase in asthma risk (OR = 1.090; 95% CI = 1.030-1.150; <i>p</i> = 0.004). No causal relationship was found for other antioxidants.</p><p><strong>Conclusions: </strong>This MR analysis suggested that genetically determined circulating urate may increase asthma risk. Further large-scale randomized controlled trials and mediated MR analysis are needed to explore underlying mechanisms.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity levels in individuals with asthma: a comparison between wearable device users and non-users: 2017 BRFSS.","authors":"Willie Leung, Maleiah Hubbard, Jinhyun Lee, Moosong Kim, Lu Shi","doi":"10.1080/02770903.2025.2555301","DOIUrl":"10.1080/02770903.2025.2555301","url":null,"abstract":"<p><strong>Objective: </strong>Despite the health benefits of physical activity (PA), many individuals with asthma are not sufficiently active. Wearable devices (WD) are increasingly popular tools for promoting PA, but limited research has examined their effectiveness among individuals with asthma. This study aims to compare PA levels between WD users and non-users with asthma.</p><p><strong>Methods: </strong>Data were drawn from the 2017 Behavioral Risk Factor Surveillance System. Participants who self-reported a diagnosis of asthma were included in this secondary data analysis. Based on the self-report, participants were categorized as WD users or non-users. PA measures included total weekly minutes of PA, weekly minutes of vigorous PA, and whether participants met national PA guidelines. Survey-weighted unadjusted and adjusted linear and logistic regression analyses were conducted to assess associations between WD use and PA outcomes.</p><p><strong>Results: </strong>Among the included 497 participants with asthma, 28.19% (95% CI [19.36, 38.30]) of participants were WD users and 71.81% (95% CI [61.7, 80.64]) were non-users. 65.91% (95% CI [57.36, 73.82]) of the participants met the PA guidelines. The unadjusted and adjusted linear regressions found no statistically significant differences in weekly PA and weekly vigorous PA between WD users and non-users. Further, no statistically significant associations were found between WD usage and meeting PA guidelines (<i>p</i> > .05).</p><p><strong>Conclusions: </strong>WD use was not associated with higher PA levels among individuals with asthma. Further research is needed to identify strategies that enhance the effectiveness of WD in promoting PA in this population.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric asthma population risk stratification using k-means clustering.","authors":"Mandana Rezaeiahari, Arina Eyimina, Melanie Boyd, Clare C Brown, Tamara T Perry, Erhan Ararat, J Mick Tilford, Akilah A Jefferson","doi":"10.1080/02770903.2025.2552745","DOIUrl":"10.1080/02770903.2025.2552745","url":null,"abstract":"<p><strong>Objectives: </strong>Incorporating social determinants of health to identify distinct pediatric asthma patient groups can help stratify populations by their risk of adverse events, improving targeted outreach and care.</p><p><strong>Methods: </strong>Insurance claims and enrollment data from the Arkansas All-Payer Claims Database identified 22 169 children aged 5-18 years with an asthma diagnosis in 2018 and continuous Medicaid enrollment in 2018 and 2019. The clustering approach used information on comorbid conditions, asthma controller medication intensity, total controller and reliever medications filled, zip code-level Child Opportunity Index, and rural-urban classification. Binary and categorical variables were first transformed into continuous latent variables using Generalized Low-Rank Models. K-means clustering with Euclidean distance was then applied. The resulting clusters were compared based on asthma-related emergency department (ED) visits and hospitalizations in 2018.</p><p><strong>Results: </strong>K-means clustering identified six clusters. The distribution of ED visits differed significantly across the clusters (<i>p</i> < 0.001) with Cluster 1 having the highest observed percentages (1 ED visit: 9.5%; ≥2 ED visits: 2.6%). This cluster consisted of 65.9% Black and had the highest proportion of children residing in neighborhoods with very low child opportunity scores: 90.5% had very low education scores, 85.5% very low health and environment scores, and 94.4% very low social and economic scores.</p><p><strong>Conclusions: </strong>Interventions to reduce pediatric asthma disparities should address social, economic, and environmental inequities. Clustering identified children from low child opportunity areas in Arkansas, with a high percentage of Black children, as a high-risk group for asthma exacerbations, underscoring the potential of population risk stratification for tailoring interventions.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma endotypes in flux: integrating type 1 and type 2 inflammation for biological therapy advancement.","authors":"Picheswara Rao Polu, Vamsi Krishna Bikki","doi":"10.1080/02770903.2025.2555300","DOIUrl":"10.1080/02770903.2025.2555300","url":null,"abstract":"<p><strong>Objective: </strong>To synthesize current understanding of type 1 (T1) and type 2 (T2) asthma endotypes and evaluate how their integration can advance precision biological therapy selection for improved patient outcomes.</p><p><strong>Data sources: </strong>Comprehensive literature review of peer-reviewed articles from PubMed, Embase, and Cochrane databases focusing on asthma immunopathology, endotype characterization, biomarker development, and biological therapies. Additional sources included clinical trial registries, regulatory agency documents, and recent conference proceedings.</p><p><strong>Study selection: </strong>Studies were selected based on relevance to T1/T2 inflammatory pathways, biomarker validation, biological therapy efficacy, and endotype-guided treatment strategies. Priority was given to randomized controlled trials, systematic reviews, and large observational studies with clear endotype characterization.</p><p><strong>Results: </strong>T2 inflammation, characterized by interleukin-4 (IL-4), IL-5, and IL-13 pathways with eosinophilic involvement, has well-established biomarkers (blood eosinophils, fractional exhaled nitric oxide (FeNO), periostin) and successful targeted biologics (anti-IL-5, anti-IL-4 receptor alpha (anti-IL-4Rα), anti-immunoglobulin E (anti-IgE)). T1 inflammation, involving interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and IL-17 with neutrophilic predominance, lacks validated biomarkers and effective therapeutics. Emerging evidence demonstrates significant T1/T2 overlap in severe asthma, challenging traditional dichotomous classification. Multi-pathway targeting strategies and upstream cytokine inhibition show promise for mixed endotypes.</p><p><strong>Conclusion: </strong>Integration of T1 and T2 endotype characterization through validated biomarkers and multi-omics approaches is essential for advancing precision medicine in asthma. Future therapeutic strategies must address endotype plasticity and mixed inflammatory patterns to optimize biological therapy selection and improve treatment outcomes in heterogeneous asthma populations.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-21"},"PeriodicalIF":1.3,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the causal role of plasma metabolites in pediatric asthma: a Mendelian randomization study.","authors":"Shaojie Ma, Wenjuan Hu, Yingwei Bi, Ying Han, Wei Wang, Deli Xin","doi":"10.1080/02770903.2025.2552748","DOIUrl":"10.1080/02770903.2025.2552748","url":null,"abstract":"<p><strong>Background: </strong>Pediatric asthma (PA) is the prevailing chronic respiratory ailment in childhood. A better understanding of plasma metabolites is the goal for elucidating the molecular pathological mechanisms of PA and investigating novel therapeutic approaches.</p><p><strong>Methods: </strong>Data for PA from Genome-Wide Association Studies (GWAS) was derived from the IEU-OpenGWAS project, featuring a collection of 1400 plasma metabolites. The inverse-variance weighting (IVW) method assessed causal relationships between plasma metabolites and PA, with measures taken to mitigate horizontal pleiotropy and heterogeneity. To select instrumental variables, a genome-wide significance threshold (<i>p</i> < 5 × 10-8) was applied to ensure robust genetic instruments. A Bonferroni correction controlled for multiple testing, with statistical significance defined as <i>p</i> < 3.57 × 10-5) (0.05/1400). To further substantiate outcomes, a reverse Mendelian randomization analysis was conducted.</p><p><strong>Results: </strong>Research found 91 plasma metabolites linked to PA, ten of which showed significant associations. Of note, 20:4n6 levels (IVW: OR (95% CI) = 1.062 (1.030 to 1.094) and G/C16 (IVW: OR (95% CI) = 0.886 (0.832 to 0.943) were identified as pivotal exposure factors for PA.</p><p><strong>Conclusions: </strong>This study highlights 10 plasma metabolites that may have significant associations with PA incidence, with 20:4n6 levels and G/C16 potentially serving as valuable biomarkers for the early detection and management of PA.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk Factors of Asthma in Children: A Systematic Review and Meta-analysis.","authors":"Li Yin, Feifei Zhang, Xue Wang, Mimi Gao, Anna Liu, Fang Li","doi":"10.1080/02770903.2025.2552749","DOIUrl":"10.1080/02770903.2025.2552749","url":null,"abstract":"<p><strong>Objective: </strong>The present study aims to evaluate the prevalence and risk factors of asthma in children through a meta-analysis.</p><p><strong>Data sources: </strong>The PubMed, Embase, Cochrane, and Web of Science databases were comprehensively retrieved for studies on the prevalence and risk factors of childhood asthma (CA) published between January 1, 2015, and July 8, 2024. Studies were screened and selected based on predefined eligibility criteria, and pertinent data were extracted. The quality of eligible studies was evaluated through the Newcastle-Ottawa Scale (NOS). Statistical analyses were undertaken via Stata 16 and R 4.4.1.</p><p><strong>Study selection: </strong>45 studies comprising 647,414 participants were included.</p><p><strong>Results: </strong>The pooled prevalence of CA was 11.9% (95% CI: 8.8-15.8%). The meta-analysis identified several risk factors for CA, including prenatal exposure to per- and polyfluoroalkyl substances (PFAS) (OR = 0.89, 95% CI: 0.80-0.98, P = 0.021), prenatal exposure to acid-suppressive medications (OR = 1.11, 95% CI: 1.04-1.19, P = 0.002), maternal folic acid supplementation during pregnancy (OR = 1.18, 95% CI: 1.10-1.27, <i>p</i> < 0.001), as well as <i>Helicobacter pylori</i> infection in childhood (OR = 2.07, 95% CI: 1.35-3.15, <i>p</i> = 0.001).</p><p><strong>Conclusions: </strong>The prevalence rate of asthma among children was approximately 11.9%. Prenatal exposure to PFAS and acid-suppressive medications, <i>Helicobacter pylori</i> infection in childhood were proved to be risk factors for asthma. Folic acid supplementation during pregnancy is positively associated with a reduced risk of asthma in children. Further large-scale prospective research is warranted to unveil the roles and significance of these factors.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into causal relationship between serum lipids, obesity, and asthma: a Mendelian randomization study.","authors":"Jialiang Sun, Lanlan Chen, Peiliang Zhao, Xinquan Bai, Shu Nie, Yanan Li","doi":"10.1080/02770903.2025.2493177","DOIUrl":"10.1080/02770903.2025.2493177","url":null,"abstract":"<p><strong>Objective: </strong>To identify causal risk factors for asthma using a Mendelian randomization (MR) approach.</p><p><strong>Methods: </strong>Genetic variants associated with the exposures at the genome-wide significance level (<i>p</i> < 5 × 10 - 8) were obtained from corresponding genome-wide association studies. Summary-level statistical data for asthma were obtained from the UK Biobank (UKB) and the FinnGen Consortia. Univariate and multivariate MR analyses were performed to clarify causal relationships among obesity, serum lipids, and asthma. Meta-analyses were performed to combine UKB and FinnGen results using a fixed-effects model.</p><p><strong>Results: </strong>In FinnGen, the odds for asthma increased for every 1-SD increase in body mass index (BMI; odds ratio [OR] 1.292, <i>p</i> = 1.34 × 10^-7), together with body fat percentage (BF%; OR 1.449, <i>p</i> = 4.90×10^-3), and total cholesterol level (OR = 0.949, <i>p</i> = 0.027). However, higher BMI and BF% were found to increase the risk for asthma in the multivariate MR analysis. In the UKB, the BMI results were replicated. Meta-analysis revealed that high-density lipoprotein cholesterol could also increase the risk for asthma, although there were no associations with other risk factors included in this study.</p><p><strong>Conclusion: </strong>This MR study found that genetically predicted higher BF% and BMI could increase the risk for asthma and corroborated some risk factors for asthma from previous MR studies. Moreover, the results suggest that higher BMI and BF% could serve as independent risk factors for asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1525-1536"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between serum urate and asthma: a Mendelian randomization study.","authors":"Guobing Jia, Tao Guo, Lei Liu, Chengshi He","doi":"10.1080/02770903.2025.2495734","DOIUrl":"10.1080/02770903.2025.2495734","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have suggested that elevated urate levels may increase the risk of asthma; however, the nature of this association remains debated. To clarify this uncertainty, we conducted a Mendelian randomization (MR) study to investigate the potential causal relationship.</p><p><strong>Methods: </strong>Summary statistics for urate were sourced from the Global Urate Genetics Consortium (GUGC), and those for asthma were obtained from the FinnGen database. Genetic variants strongly associated with urate were selected as instrumental variables (IVs). Univariable and multivariable MR analyses were conducted to investigate the causal relationship between urate and asthma. Subsequently, network MR analyses were performed to reveal the mediating role of urate in the relationship between body mass index (BMI) and asthma.</p><p><strong>Results: </strong>The univariable MR analysis showed that urate was associated with an increased risk of asthma (IVW OR = 1.13, 95%CI = 1.04-1.23, <i>p</i> = 0.004). This causal relationship remained consistent in multivariable MR analyses, even after adjusting for potential confounders, including smoking initiation, cigarettes per day, alcohol intake frequency, BMI, allergic rhinitis, and gastroesophageal reflux disease (GERD). Furthermore, network MR analyses demonstrated that the proportion of causal effect between BMI and asthma mediated by urate was 18.05% (95%CI = 6.23%-29.88%).</p><p><strong>Conclusion: </strong>Our study confirms that serum urate is associated with an increased risk of asthma, suggesting its potential as a target for both prevention and treatment. Additionally, our findings indicate that urate partially mediates the relationship between BMI and asthma, emphasizing its role in the mechanism underlying BMI-induced asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1575-1583"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe asthma, biologic hypersensitivity and inefficacy: overcoming treatment barriers with tezepelumab.","authors":"Maria Bragança, Inês Barreto, Henrique Rodrigues, Ana Mendes, Carlos Lopes","doi":"10.1080/02770903.2025.2552744","DOIUrl":"https://doi.org/10.1080/02770903.2025.2552744","url":null,"abstract":"<p><p>Severe asthma is a heterogeneous disease involving multiple inflammatory pathways, with significant therapeutic challenges. Biologic therapies targeting T2 inflammation improve outcomes but may, in rare cases, trigger hypersensitivity reactions due to anti-drug antibodies, excipients, or protein structure. Additionally, some patients exhibit suboptimal or no response. Tezepelumab, a thymic stromal lymphopoietin inhibitor, offers a novel upstream approach, addressing diverse endotypes.</p><p><p>We present a 30-year-old female with severe T2-high asthma, multiple allergies, and poor disease control despite optimal therapy. She experienced an allergic reaction with omalizumab and dupilumab and had inadequate response to benralizumab. Enrolled in an early access program for tezepelumab, she showed remarkable clinical improvement, with significant FEV1 increase and FeNO reduction, allowing discontinuation of systemic corticosteroids and supplemental oxygen.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-5"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}