饮食抗氧化剂:哮喘的挑战还是机遇?来自两样本孟德尔随机化研究的遗传学见解。

IF 1.3 4区 医学 Q3 ALLERGY
Xiaoqing Zhou, Yujie Zhou, Jialing Chen, Chen Chen, Ruilin Chen, Suqun Zheng, Zhen Wang, Linshui Zhou
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引用次数: 0

摘要

背景:氧化应激在哮喘相关的免疫反应和气道炎症过程中至关重要。虽然饮食抗氧化剂和哮喘之间的关系在观察性研究中仍有争议,但本研究使用双样本孟德尔随机化(MR)来探索潜在的因果关系。方法:我们从最新的欧洲人群全基因组关联研究数据中获得了六种不同类型的绝对循环抗氧化剂和五种不同类型的代谢循环抗氧化剂,包括维生素A(视黄醇)、维生素C(抗坏血酸)、维生素E(生育酚)、β-胡萝卜素、番茄红素和尿酸盐。有关哮喘的最新数据来自FinnGen数据库。我们利用单核苷酸多态性作为工具变量进行了五种MR方法。为了确认结果的准确性,进行了额外的敏感性分析,以消除任何潜在的混杂因素,如异质性和多效性。结果:MR和敏感性分析显示循环尿酸与哮喘之间存在关联,提示哮喘风险可能增加(OR = 1.090; 95% CI = 1.030-1.150; P = 0.004)。其他抗氧化剂没有发现因果关系。结论:磁共振分析表明,基因决定的循环尿酸可能增加哮喘风险。需要进一步的大规模随机对照试验和介导的MR分析来探索潜在的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dietary antioxidants: a challenge or an opportunity for asthma? Genetic insights from a Two-sample mendelian randomization study.

Background: Oxidative stress is crucial in the immune response and airway inflammatory process associated with asthma. While the relationship between dietary antioxidants and asthma remains debated in observational studies, this study uses two-sample Mendelian randomization (MR) to explore a potential causal link.

Methods: We acquired six distinct categories of absolute circulating antioxidants and five different types of metabolic circulating antioxidants from the most recent genome-wide association study data of the European population, including vitamin A (retinol), vitamin C (ascorbic acid), vitamin E (tocopherol), β-carotene, lycopene, and urate. The latest data regarding asthma was obtained from the FinnGen database. We utilized single nucleotide polymorphisms as instrumental variables to conduct five MR methods. To confirm the accuracy of the results, additional sensitivity analyses were performed to eliminate any potential confounding factors, such as heterogeneity and pleiotropy.

Results: MR and sensitivity analyses revealed an association between circulating urate and asthma, suggesting a potential increase in asthma risk (OR = 1.090; 95% CI = 1.030-1.150; p = 0.004). No causal relationship was found for other antioxidants.

Conclusions: This MR analysis suggested that genetically determined circulating urate may increase asthma risk. Further large-scale randomized controlled trials and mediated MR analysis are needed to explore underlying mechanisms.

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来源期刊
Journal of Asthma
Journal of Asthma 医学-过敏
CiteScore
4.00
自引率
5.30%
发文量
158
审稿时长
3-8 weeks
期刊介绍: Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.
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