Li Yin, Feifei Zhang, Xue Wang, Mimi Gao, Anna Liu, Fang Li
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Statistical analyses were undertaken via Stata 16 and R 4.4.1.</p><p><strong>Study selection: </strong>45 studies comprising 647,414 participants were included.</p><p><strong>Results: </strong>The pooled prevalence of CA was 11.9% (95% CI: 8.8-15.8%). The meta-analysis identified several risk factors for CA, including prenatal exposure to per- and polyfluoroalkyl substances (PFAS) (OR = 0.89, 95% CI: 0.80-0.98, P = 0.021), prenatal exposure to acid-suppressive medications (OR = 1.11, 95% CI: 1.04-1.19, P = 0.002), maternal folic acid supplementation during pregnancy (OR = 1.18, 95% CI: 1.10-1.27, <i>p</i> < 0.001), as well as <i>Helicobacter pylori</i> infection in childhood (OR = 2.07, 95% CI: 1.35-3.15, <i>p</i> = 0.001).</p><p><strong>Conclusions: </strong>The prevalence rate of asthma among children was approximately 11.9%. Prenatal exposure to PFAS and acid-suppressive medications, <i>Helicobacter pylori</i> infection in childhood were proved to be risk factors for asthma. Folic acid supplementation during pregnancy is positively associated with a reduced risk of asthma in children. Further large-scale prospective research is warranted to unveil the roles and significance of these factors.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-12"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence and Risk Factors of Asthma in Children: A Systematic Review and Meta-analysis.\",\"authors\":\"Li Yin, Feifei Zhang, Xue Wang, Mimi Gao, Anna Liu, Fang Li\",\"doi\":\"10.1080/02770903.2025.2552749\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The present study aims to evaluate the prevalence and risk factors of asthma in children through a meta-analysis.</p><p><strong>Data sources: </strong>The PubMed, Embase, Cochrane, and Web of Science databases were comprehensively retrieved for studies on the prevalence and risk factors of childhood asthma (CA) published between January 1, 2015, and July 8, 2024. 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引用次数: 0
摘要
目的:本研究旨在通过荟萃分析评估儿童哮喘患病率及危险因素。数据来源:全面检索PubMed、Embase、Cochrane和Web of Science数据库,检索2015年1月1日至2024年7月8日期间发表的关于儿童哮喘(CA)患病率和危险因素的研究。根据预先设定的资格标准筛选和选择研究,并提取相关数据。通过纽卡斯尔-渥太华量表(NOS)评估符合条件的研究的质量。通过Stata 16和r4.4.1进行统计分析。研究选择:纳入45项研究,共647,414名受试者。结果:CA的总患病率为11.9% (95% CI: 8.8%-15.8%)。荟萃分析确定了CA的几个危险因素,包括产前暴露于全氟烷基和多氟烷基物质(PFAS) (OR = 0.89, 95% CI: 0.80-0.98, P = 0.021),产前暴露于抑酸药物(OR = 1.11, 95% CI: 1.04-1.19, P = 0.002),怀孕期间母体补充叶酸(OR = 1.18, 95% CI: 1.10-1.27, P < 0.001),以及儿童期幽门螺杆菌感染(OR = 2.07, 95% CI: 1.35-3.15, P = 0.001)。研究选择。结论:儿童哮喘患病率约为11.9%。产前暴露于PFAS和抑酸药物,儿童期幽门螺杆菌感染被证明是哮喘的危险因素。怀孕期间补充叶酸与降低儿童哮喘风险呈正相关。为了揭示这些因素的作用和意义,有必要进一步进行大规模的前瞻性研究。
Prevalence and Risk Factors of Asthma in Children: A Systematic Review and Meta-analysis.
Objective: The present study aims to evaluate the prevalence and risk factors of asthma in children through a meta-analysis.
Data sources: The PubMed, Embase, Cochrane, and Web of Science databases were comprehensively retrieved for studies on the prevalence and risk factors of childhood asthma (CA) published between January 1, 2015, and July 8, 2024. Studies were screened and selected based on predefined eligibility criteria, and pertinent data were extracted. The quality of eligible studies was evaluated through the Newcastle-Ottawa Scale (NOS). Statistical analyses were undertaken via Stata 16 and R 4.4.1.
Study selection: 45 studies comprising 647,414 participants were included.
Results: The pooled prevalence of CA was 11.9% (95% CI: 8.8-15.8%). The meta-analysis identified several risk factors for CA, including prenatal exposure to per- and polyfluoroalkyl substances (PFAS) (OR = 0.89, 95% CI: 0.80-0.98, P = 0.021), prenatal exposure to acid-suppressive medications (OR = 1.11, 95% CI: 1.04-1.19, P = 0.002), maternal folic acid supplementation during pregnancy (OR = 1.18, 95% CI: 1.10-1.27, p < 0.001), as well as Helicobacter pylori infection in childhood (OR = 2.07, 95% CI: 1.35-3.15, p = 0.001).
Conclusions: The prevalence rate of asthma among children was approximately 11.9%. Prenatal exposure to PFAS and acid-suppressive medications, Helicobacter pylori infection in childhood were proved to be risk factors for asthma. Folic acid supplementation during pregnancy is positively associated with a reduced risk of asthma in children. Further large-scale prospective research is warranted to unveil the roles and significance of these factors.
期刊介绍:
Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.