Zeynep Celebi Sozener, Ipek Kıvılcım Oguzulgen, Funda Seher Ozalp Ates, Ayse Baccioglu, Serap Argun Barıs, Dane Ediger, Fatma Esra Gunaydın, Can Sevinc, Ummuhan Seker, Bilge Yılmaz Kara, Sengul Beyaz, Dilsad Mungan, Omur Aydin, Derya Gokmen, Gozde Koycu Buhari, Bilun Gemicioglu, Ismet Bulut, Cihan Orcen, Secil Kepil Ozdemir, Metin Keren, Ebru Damadoglu, Tugce Yakut, Ayse Fusun Kalpaklioglu, Sumeyra Alan Yalim, Insu Yilmaz, Ilkay Koca Kalkan, Mehmet Atilla Uysal, Elif Yelda Ozgun Niksarlioglu, Ali Fuat Kalyoncu, Gul Karakaya, Muge Erbay, Sibel Nayci, Fatma Merve Tepetam, Asli Akkor Gelincik, Hulya Dirol, Ozlem Goksel, Selen Karaoglanoglu, Ferda Oner Erkekol, Sacide Rana Isik, Fusun Yildiz, Yasemin Yavuz, Dilek Karadogan, Nurgul Bozkurt, Ilknur Basyigit, Elif Yilmazel Ucar, Tuba Erdogan, Mehmet Polatli, Murat Turk, Leyla Pur, Zeynep Yegin Katran, Yonca Sekibag, Enes Furkan Aykac, Ozcan Gul, Ali Cengiz, Bulent Akkurt, Seyma Ozden, Semra Demir, Derya Unal, Ayse Feyza Aslan, Ali Can, Reyhan Gumusburun, Gulhan Bogatekin, Hatice Serpil Akten, Sinem Inan, Munevver Erdinc, Aliye Candan Ogus, Murat Kavas, Demet Polat Yulug, Mehmet Erdem Cakmak, Saltuk Bugra Kaya, Gulistan Alpagat, Eylem Sercan Ozgur, Oguz Uzun, Sule Tas Gulen, Gulseren Pekbak, Deniz Kizilirmak, Yavuz Havlucu, Halil Donmez, Bahar Arslan, Gulden Pacaci Cetin, Sadan Soyyigit, Gulden Pasaoglu Karakis, Adile Berna Dursun, Resat Kendirlinan, Ayse Bilge Ozturk, Gokcen Omeroglu Simsek, Oznur Abadoglu, Pamir Cerci, Taskin Yucel, Irfan Yorulmaz, Zahide Ciler Tezcaner, Emel Cadalli Tatar, Ahmet Emre Suslu, Serdar Ozer, Engin Dursun, Arzu Yorgancioglu, Gulfem Elif Celik
{"title":"Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry.","authors":"Zeynep Celebi Sozener, Ipek Kıvılcım Oguzulgen, Funda Seher Ozalp Ates, Ayse Baccioglu, Serap Argun Barıs, Dane Ediger, Fatma Esra Gunaydın, Can Sevinc, Ummuhan Seker, Bilge Yılmaz Kara, Sengul Beyaz, Dilsad Mungan, Omur Aydin, Derya Gokmen, Gozde Koycu Buhari, Bilun Gemicioglu, Ismet Bulut, Cihan Orcen, Secil Kepil Ozdemir, Metin Keren, Ebru Damadoglu, Tugce Yakut, Ayse Fusun Kalpaklioglu, Sumeyra Alan Yalim, Insu Yilmaz, Ilkay Koca Kalkan, Mehmet Atilla Uysal, Elif Yelda Ozgun Niksarlioglu, Ali Fuat Kalyoncu, Gul Karakaya, Muge Erbay, Sibel Nayci, Fatma Merve Tepetam, Asli Akkor Gelincik, Hulya Dirol, Ozlem Goksel, Selen Karaoglanoglu, Ferda Oner Erkekol, Sacide Rana Isik, Fusun Yildiz, Yasemin Yavuz, Dilek Karadogan, Nurgul Bozkurt, Ilknur Basyigit, Elif Yilmazel Ucar, Tuba Erdogan, Mehmet Polatli, Murat Turk, Leyla Pur, Zeynep Yegin Katran, Yonca Sekibag, Enes Furkan Aykac, Ozcan Gul, Ali Cengiz, Bulent Akkurt, Seyma Ozden, Semra Demir, Derya Unal, Ayse Feyza Aslan, Ali Can, Reyhan Gumusburun, Gulhan Bogatekin, Hatice Serpil Akten, Sinem Inan, Munevver Erdinc, Aliye Candan Ogus, Murat Kavas, Demet Polat Yulug, Mehmet Erdem Cakmak, Saltuk Bugra Kaya, Gulistan Alpagat, Eylem Sercan Ozgur, Oguz Uzun, Sule Tas Gulen, Gulseren Pekbak, Deniz Kizilirmak, Yavuz Havlucu, Halil Donmez, Bahar Arslan, Gulden Pacaci Cetin, Sadan Soyyigit, Gulden Pasaoglu Karakis, Adile Berna Dursun, Resat Kendirlinan, Ayse Bilge Ozturk, Gokcen Omeroglu Simsek, Oznur Abadoglu, Pamir Cerci, Taskin Yucel, Irfan Yorulmaz, Zahide Ciler Tezcaner, Emel Cadalli Tatar, Ahmet Emre Suslu, Serdar Ozer, Engin Dursun, Arzu Yorgancioglu, Gulfem Elif Celik","doi":"10.1080/02770903.2025.2466182","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma.</p><p><strong>Methods: </strong>This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR). Clinical presentation, disease control, severity, and demographics of obese and non-obese (normal-weight, overweight) patients were compared.</p><p><strong>Results: </strong>The obesity rate in TAAR was 32.2% (<i>n</i> = 619/1919; 18-83 years; 527 F/92 M). Patients with asthma and obesity had higher rates of childhood obesity, longer symptom duration, later onset of asthma, and more severe asthma. These patients were more likely to be female, older, less educated, and live in rural areas. Patients with obesity had more scheduled visits and emergency visits compared with non-obese patients, but similar asthma control, oral corticosteroid use, hospitalizations, intensive care unit admissions, and unscheduled visits. They also had a higher frequency of T2-high but lower frequency of possible T2-low phenotypes compared with normal-weight asthmatics. The risk of severe asthma in patients with obesity was 6.04 times higher for allergic than non-allergic patients and 3.58 times higher for the T2-high phenotype than for possible T2-low phenotypes. A one-unit increase in the asthma control test reduced the risk of severe asthma by 22%.</p><p><strong>Conclusions: </strong>A good definition of this phenotype is important to ensure that appropriate treatment strategies are implemented to achieve the control goal. We also believe that prevention of childhood obesity is an effective and pivotal strategy to achieve the goal of asthma control.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.7000,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asthma","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02770903.2025.2466182","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma.
Methods: This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR). Clinical presentation, disease control, severity, and demographics of obese and non-obese (normal-weight, overweight) patients were compared.
Results: The obesity rate in TAAR was 32.2% (n = 619/1919; 18-83 years; 527 F/92 M). Patients with asthma and obesity had higher rates of childhood obesity, longer symptom duration, later onset of asthma, and more severe asthma. These patients were more likely to be female, older, less educated, and live in rural areas. Patients with obesity had more scheduled visits and emergency visits compared with non-obese patients, but similar asthma control, oral corticosteroid use, hospitalizations, intensive care unit admissions, and unscheduled visits. They also had a higher frequency of T2-high but lower frequency of possible T2-low phenotypes compared with normal-weight asthmatics. The risk of severe asthma in patients with obesity was 6.04 times higher for allergic than non-allergic patients and 3.58 times higher for the T2-high phenotype than for possible T2-low phenotypes. A one-unit increase in the asthma control test reduced the risk of severe asthma by 22%.
Conclusions: A good definition of this phenotype is important to ensure that appropriate treatment strategies are implemented to achieve the control goal. We also believe that prevention of childhood obesity is an effective and pivotal strategy to achieve the goal of asthma control.
期刊介绍：
Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.
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