{"title":"Linking anemia to asthma: maternal, childhood and adult perspectives from a meta-analysis of 20 studies.","authors":"Kaiwen Zheng, Xiang Wang","doi":"10.1080/02770903.2025.2499837","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Anemia has been implicated as a potential risk factor for asthma across different life stages, yet evidence remains inconsistent.</p><p><strong>Objective: </strong>This meta-analysis (CRD420251008733) aimed to evaluate the associations between maternal anemia and offspring asthma, childhood anemia and asthma, and adult anemia and asthma.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Web of Science, and Cochrane Library, identifying 20 observational studies. Study quality was assessed using the Newcastle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ) checklist. Heterogeneity, sensitivity, and publication bias were explored through subgroup analyses, sensitivity tests, and Egger's test. Meta-analysis performed using Stata 17.</p><p><strong>Results: </strong>Twenty studies involving over 4499364 participants were included. The results showed pooled OR for the association between anemia and asthma (OR = 1.55, 95% CI: 1.36-1.77). Maternal anemia during pregnancy was associated with a modest increase in offspring asthma risk (OR = 1.19, 95% CI: 1.02-1.38), adult anemia was also linked to asthma (OR = 1.94, 95% CI: 1.14-3.30). Childhood anemia showed a stronger association with asthma (OR = 2.22, 95% CI: 1.65-2.99), though Egger's test (<i>p</i> = 0.041) suggested publication bias, with an adjusted OR of 2.03 (95% CI: 1.51-2.74).</p><p><strong>Conclusions: </strong>Anemia is significantly associated with an increased risk of asthma, particularly in children. These findings suggest a potential role for anemia screening in asthma management.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1459-1471"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asthma","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02770903.2025.2499837","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Anemia has been implicated as a potential risk factor for asthma across different life stages, yet evidence remains inconsistent.
Objective: This meta-analysis (CRD420251008733) aimed to evaluate the associations between maternal anemia and offspring asthma, childhood anemia and asthma, and adult anemia and asthma.
Methods: We searched PubMed, Embase, Web of Science, and Cochrane Library, identifying 20 observational studies. Study quality was assessed using the Newcastle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ) checklist. Heterogeneity, sensitivity, and publication bias were explored through subgroup analyses, sensitivity tests, and Egger's test. Meta-analysis performed using Stata 17.
Results: Twenty studies involving over 4499364 participants were included. The results showed pooled OR for the association between anemia and asthma (OR = 1.55, 95% CI: 1.36-1.77). Maternal anemia during pregnancy was associated with a modest increase in offspring asthma risk (OR = 1.19, 95% CI: 1.02-1.38), adult anemia was also linked to asthma (OR = 1.94, 95% CI: 1.14-3.30). Childhood anemia showed a stronger association with asthma (OR = 2.22, 95% CI: 1.65-2.99), though Egger's test (p = 0.041) suggested publication bias, with an adjusted OR of 2.03 (95% CI: 1.51-2.74).
Conclusions: Anemia is significantly associated with an increased risk of asthma, particularly in children. These findings suggest a potential role for anemia screening in asthma management.
期刊介绍:
Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.