二手烟暴露与儿童哮喘患者IL-17基因多态性的相互作用

IF 1.3 4区 医学 Q3 ALLERGY
Berrak Oztosun, Azer Kilic Baskan, Aysel Kalayci, Deniz Ozceker, Mehmet Seven, Haluk Cokugras, Ayse Ayzit Kilinc Sakalli
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引用次数: 0

摘要

背景:哮喘是一种多因素疾病,影响全球约3亿人。多种基因、环境风险因素及其相互作用与哮喘有关。吸烟引发il -17介导的炎症反应。IL-17相关的炎症反应可能在个体之间存在差异,这种差异与IL-17多态性有关。目的:探讨IL-17多态性对儿童哮喘的影响及其与二手烟的相互作用。方法:选取100例儿童哮喘患者和100例健康儿童作为研究对象。分析可替宁水平以显示SHS暴露(SHSe)。对IL-17F(rs763780)和IL-17A (rs8193036、rs2275913)的多态性进行遗传分析。根据可替宁的结果,研究参与者被分为四组:哮喘伴SHSe,哮喘不伴SHSe,伴SHSe的对照组和不伴SHSe的对照组。结果:可替宁中位浓度为11,06 ng/ml。结论:本研究首次证实了IL-17多态性与儿童哮喘SHS相互作用之间的关系。没有发现IL-17多态性的存在以及这些多态性与SHS的相互作用相关。哮喘儿童体内较低的可替宁水平表明父母更容易患SHSe。在我们的队列中,可替宁的水平明显高于发达国家。这表明,暴露于SHS在我国仍然是一个严重的环境问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interaction between secondhand smoke exposure and IL-17 gene polymorphism in pediatric asthma.

Background: Asthma is a multifactorial disease affecting approximately 300 million people worldwide. Multiple genes, environmental risk factors, and their interactions have been associated with asthma. Smoking triggers an IL-17-mediated inflammatory response. The IL-17-related inflammatory response may differ between individuals, and this difference is associated with IL-17 polymorphisms.

Objective: Our aim was to investigate the effect of IL-17 polymorphism and its interaction with secondhand smoke on pediatric asthma.

Methods: The study comprised 100 pediatric asthma patients and 100 healthy children. Cotinine levels were analyzed to show SHS exposure (SHSe). A genetic study was conducted to reveal IL-17F(rs763780) and IL-17A (rs8193036, rs2275913) polymorphisms. The study participants were categorized into four groups based on the cotinine results: asthma with SHSe, asthma without SHSe, control with SHSe, and control without SHSe.

Results: The median cotinine concentration was 11.06 ng/ml. Children with asthma had lower cotinine levels than healthy children (p < 0.001). Genotype distributions and allele frequencies of rs763780, rs8193036, and rs2275913 were compared among the four groups, and no significant differences were found.

Conclusion: This study is the first to demonstrate the relationship between IL-17 polymorphisms and SHS interaction in childhood asthma. Neither the presence of IL-17 polymorphisms nor the interaction of these polymorphisms with SHS was found to be associated. The lower cotinine levels in asthmatic children suggest that parents are more susceptible to SHSe. Cotinine levels in our cohort were significantly greater than those found in developed countries. This demonstrates that exposure to SHS is still a serious environmental issue in our country.

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来源期刊
Journal of Asthma
Journal of Asthma 医学-过敏
CiteScore
4.00
自引率
5.30%
发文量
158
审稿时长
3-8 weeks
期刊介绍: Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.
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