吸烟对体外倍氯米松/福莫特罗控制哮喘的影响:一项前瞻性队列研究的事后分析。

IF 1.7 4区 医学 Q3 ALLERGY
Izabela Kupryś-Lipińska, Tomasz Dębowski, Cezary Palczyński, Roman Hożejowski, Piotr Lacwik, Piotr Kuna
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引用次数: 0

摘要

目的暴露于烟草烟雾是哮喘控制不良的主要危险因素。我们的目的是评估基于患者吸烟状况的哮喘治疗反应。方法:本事后分析使用了一项大型前瞻性队列研究的数据,该研究的患者均接受了吸入的超细倍氯米松/福莫特罗治疗。回顾性地将患者分为当前吸烟者、曾经吸烟者和不吸烟者。使用全球哮喘倡议(GINA)标准评估6个月内的哮喘控制和症状严重程度。主要结局是达到改善GINA类别哮喘控制的患者比例,而次要结局是哮喘控制良好的比例。为了解释基线差异,根据年龄、性别、体重指数、自我报告的身体活动、教育水平和FEV1进行倾向评分匹配(1:1:1)。结果从17098例患者的初始队列中,选择了2856例(每组952例)的匹配样本,确保了可比较的基线特征。6个月后,78%的吸烟者、75%的戒烟者和77%的不吸烟者的GINA分类得到改善(p = 0.381)。控制良好的哮喘发生率在两组间具有可比性(当前吸烟者:58%,前吸烟者:54%;不吸烟者:57% (p = 0.255)。未控制的哮喘仍然不常见,但在当前吸烟者(10%)和前吸烟者(8.9%)中比在非吸烟者(5.7%)中更为普遍(p = 0.002和p = 0.033)。结论哮喘患者,无论是否吸烟,对治疗表现出相似的反应。不受控制的哮喘虽然在治疗中很少见,但在吸烟者中更为常见,因为他们的基线严重程度较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of smoking on asthma control with extrafine beclomethasone/formoterol: post hoc analysis of a prospective cohort study.

Objective: Exposure to tobacco smoke is a major risk factor for poor asthma control. We aimed to assess the response to asthma treatment based on patients' smoking status.

Methods: This post hoc analysis used data from a large prospective asthma cohort treated with inhaled extrafine beclomethasone/formoterol. Patients were retrospectively categorized as current smokers, former smokers, or nonsmokers. Asthma control and symptom severity were evaluated over 6 months using Global Initiative for Asthma (GINA) criteria. The primary outcome was the proportion of patients who achieved an improved GINA category of asthma control, while the secondary outcome was the proportion with well-controlled asthma. To account for baseline differences, the cohorts were propensity score-matched (1:1:1) based on age, sex, body mass index, self-reported physical activity, education level, and FEV1.

Results: From an initial cohort of 17 098 patients, a matched sample of 2856 (952 per group) was selected, ensuring comparable baseline characteristics. After 6 months, an improved GINA category was observed in 78% of current smokers, 75% of former smokers, and 77% of nonsmokers (p = 0.381). The rates of well-controlled asthma were comparable across groups (current smokers: 58%, former smokers: 54%; nonsmokers: 57%, p = 0.255). Uncontrolled asthma remained infrequent but was more prevalent in current (10%) and former (8.9%) smokers than in nonsmokers (5.7%) (p = 0.002 and p = 0.033, respectively).

Conclusions: Asthma patients, regardless of smoking status, demonstrate a similar response to treatment. Uncontrolled asthma, though rare under treatment, is more common among smokers, due to their higher baseline severity.

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来源期刊
Journal of Asthma
Journal of Asthma 医学-过敏
CiteScore
4.00
自引率
5.30%
发文量
158
审稿时长
3-8 weeks
期刊介绍: Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.
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