Journal of Asthma最新文献_第2页

Asthma incidence, prevalence, and mortality in the United States and worldwide, 1990-2019: Findings from the Global Burden of Disease study. 1990-2019年美国和全球哮喘发病率、患病率和死亡率：全球疾病负担研究结果

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 DOI: 10.1080/02770903.2025.2482998

Hamza Ashraf, Mahad Butt, Shanzay Akhtar, Aimen Nadeem, Rutaab Kareem, Haider Ashfaq, Zain Ali Nadeem, Maurish Fatima, Ali Ashraf, Jenish Bhandari

{"title":"Asthma incidence, prevalence, and mortality in the United States and worldwide, 1990-2019: Findings from the Global Burden of Disease study.","authors":"Hamza Ashraf, Mahad Butt, Shanzay Akhtar, Aimen Nadeem, Rutaab Kareem, Haider Ashfaq, Zain Ali Nadeem, Maurish Fatima, Ali Ashraf, Jenish Bhandari","doi":"10.1080/02770903.2025.2482998","DOIUrl":"10.1080/02770903.2025.2482998","url":null,"abstract":"Introduction: Asthma is a serious global health issue, contributing to premature deaths and reduced quality of life.Objective: This study examines trends in the incidence, prevalence, and mortality of asthma in the US and globally from 1990 to 2019.Methods: Data from the Global Burden of Disease database were used to calculate age-standardized incidence (ASIR), prevalence (ASPR), and mortality (ASMR) rates per 100,000 individuals, stratified by gender. Joinpoint regression analysis determined annual percent changes (APCs), and average annual percentage changes (AAPCs) were calculated as weighted averages of these trends.Results: In the US, ASIR increased by 10.2%, rising from 1404.6 in 1990 to 1547.2 in 2019, with an overall AAPC of 0.33. Globally, ASIR decreased by 13%, declining from 580.1 to 504.3, with an overall AAPC of -0.46. ASPR in the US rose from 9374.0 to 10399.3, reflecting a 0.37% annual increase, whereas globally, ASPR dropped by 24.1%, decreasing from 4496.9 to 3415.5 with an overall AAPC of -0.91. Females consistently exhibited higher ASPR rates than males in both settings. US asthma mortality decreased by 50%, with ASMR dropping from 1.66 to 0.87 and an AAPC of -2.15. Globally, ASMR decreased by 51.3%, falling from 11.91 to 5.80, with an overall AAPC of -2.47.Conclusion: Males globally showed higher ASMR, whereas in the US, females had higher rates. While asthma incidence and prevalence increased in the US, global rates declined. Both the US and global populations experienced substantial reductions in asthma-related mortality, highlighting the need for targeted interventions and international collaboration.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroticism and asthma: Mendelian randomization analysis reveals causal link with mood swings and BMI mediation. 神经质和哮喘：孟德尔随机分析揭示情绪波动和BMI中介的因果关系。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 Epub Date: 2024-12-19 DOI: 10.1080/02770903.2024.2434516

Dong-Cai Wu, Xin-Yue Zhang, An-Dong Li, Tan Wang, Zi-Yuan Wang, Si-Yu Song, Meng-Zhu Chen

{"title":"Neuroticism and asthma: Mendelian randomization analysis reveals causal link with mood swings and BMI mediation.","authors":"Dong-Cai Wu, Xin-Yue Zhang, An-Dong Li, Tan Wang, Zi-Yuan Wang, Si-Yu Song, Meng-Zhu Chen","doi":"10.1080/02770903.2024.2434516","DOIUrl":"10.1080/02770903.2024.2434516","url":null,"abstract":"Background: Neuroticism has been associated with asthma, but the nature of this relationship remains unclear due to limited understanding of the impact of psychological factors on asthma risk. While Neuroticism is known to affect various health outcomes, its specific role in respiratory conditions like asthma is not fully understood.Methods: We conducted Mendelian randomization (MR) analyses using genome-wide association studies (GWAS) to explore the causal link between 12 Neuroticism traits and asthma. Various MR approaches, including MR-PRESSO, were employed, with validation through independent GWAS and the FinnGen dataset.Results: MR-PRESSO revealed a significant causal relationship between mood swings and asthma (OR: 1.927, 95% CI: 1.641-2.263), surpassing the Bonferroni-corrected threshold (p < 4.167 × 10-³). Mood swings emerged as the only significant trait associated with asthma, with reverse MR analyses showing no causal links for other traits. Secondary analyses supported these findings. Multivariate analysis showed mood swings increased asthma risk, independent of smoking, BMI, and air pollution. Mediation analysis indicated that BMI partially mediates the mood swing-asthma relationship, accounting for 9.87% of the effect (95% CI: 4.54%-15.2%, p = 2.850 × 10-4).Conclusion: Mood swings elevate asthma risk, with BMI partially mediating this effect, highlighting a potentially significant pathway through which psychological traits influence asthma.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"674-683"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiating asthma and tracheal stenosis: why confirmation of the diagnosis of asthma should precede treatment. 哮喘与气管狭窄的鉴别：为何确诊哮喘应先于治疗？

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 Epub Date: 2024-12-09 DOI: 10.1080/02770903.2024.2434507

Ananna Kazi, Sarah Shidid, Anna Katrina Gutierrez, Denisa Ferastraoaru

{"title":"Differentiating asthma and tracheal stenosis: why confirmation of the diagnosis of asthma should precede treatment.","authors":"Ananna Kazi, Sarah Shidid, Anna Katrina Gutierrez, Denisa Ferastraoaru","doi":"10.1080/02770903.2024.2434507","DOIUrl":"10.1080/02770903.2024.2434507","url":null,"abstract":"Introduction: Asthma is a common respiratory condition; however, its symptoms often overlap with other diseases, posing diagnostic challenges. Tracheal stenosis, often seen in patients with a history of intubation, can mimic asthma symptoms, leading to misdiagnosis.Case study: This case study discusses a 58-year-old female with hypertension, type 2 diabetes, and obesity. She was initially treated for presumed asthma for over a year without confirming the diagnosis with pulmonary function tests (PFTs). Despite multiple steroid treatments for exacerbations, her condition deteriorated, leading to hospitalization. During hospitalization, her symptoms were minimally improved with steroid and nebulizer treatments. Examination revealed inspiratory stridor, and a subsequent CT scan identified subglottic tracheal stenosis. Flexible bronchoscopy confirmed the stenosis, successfully treated with balloon dilation. Post-procedure, her PFTs showed mild obstruction without bronchodilator response, her shortness of breath resolved, and her exercise tolerance improved markedly without ongoing asthma treatment.Discussion: Asthma symptoms, including dyspnea, wheezing, cough, and chest tightness, frequently overlap with tracheal stenosis. Early differentiation is crucial to avoid misdiagnosis, reduce unnecessary treatments, and prevent complications. Recognizing risk factors, such as obesity, diabetes, female gender, and prior intubation, and employing diagnostic tools, such as PFTs and CT scan of the neck help diagnose tracheal stenosis. Prompt bronchoscopy and appropriate intervention can dramatically improve patient outcomes.Conclusion: This case underscores the importance of heightened clinical suspicion and comprehensive diagnostic evaluation in patients with persistent treatment-resistant asthma-like symptoms, particularly those with a history of intubation, for timely diagnosis of tracheal stenosis.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"737-740"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal association between allergic diseases and celiac disease: a bidirectional two-sample and multivariable Mendelian-randomization study. 过敏性疾病与乳糜泻之间的因果关系：一项双向双样本多变量孟德尔随机研究。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 Epub Date: 2024-11-09 DOI: 10.1080/02770903.2024.2425370

Jun-Bo Wang, Hai-Lan Li, Xin Ming, Jin-Xiu Feng, Zhi-Li Hu, Li Zhou

{"title":"Causal association between allergic diseases and celiac disease: a bidirectional two-sample and multivariable Mendelian-randomization study.","authors":"Jun-Bo Wang, Hai-Lan Li, Xin Ming, Jin-Xiu Feng, Zhi-Li Hu, Li Zhou","doi":"10.1080/02770903.2024.2425370","DOIUrl":"10.1080/02770903.2024.2425370","url":null,"abstract":"Objective: This study aimed to assess the causality of allergic diseases and celiac disease.Methods: We collected summary-level data from publicly available genome-wide association studies to conduct our bidirectional two-sample and multivariable Mendelian randomization analysis. Furthermore, a series of sensitivity analyses were applied to validate our findings.Results: In bidirectional two-sample MR analyses, we found a significant causal effect of atopic dermatitis (AD) on CD (Inverse-variance weighted (IVW): odds ratio [OR] = 1.302, 95% confidence interval [CI] = 1.152-1.471, p < 0.001). We also found a significant causal effect of allergic rhinitis (AR) on CD (IVW: OR = 4.181, 95% CI = 1.495-11.697, p = 0.006). However, the MR-Egger method indicated a different causal effect direction compared to the IVW and weighted median method. After Bonferroni correction, the result of asthma on CD is suggestive of a causal effect (IVW: OR = 1.186, 95% CI = 1.021-1.378, p = 0.026). No causal effects were found when CD was considered as an exposure variable. In MVMR analyses, after separately and jointly adjusting for the influence of smoking and BMI, the causal effect of AD on CD remained robust.Conclusions: Our study suggests that AD is a risk factor for CD and it is considered suggestive of a causal relationship between asthma and CD. Further research is needed to explore the potential mechanisms underlying this causal effect.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"621-627"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability of 24-h measurement of physical activity, sleep, and sedentary time in adult patients with asthma using a triaxial accelerometer. 使用三轴加速度计对成年哮喘患者的体力活动、睡眠和久坐时间进行 24 小时测量的可靠性。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 Epub Date: 2024-11-01 DOI: 10.1080/02770903.2024.2420758

S M J Janssen, M A Spruit, R S Djamin, J C C M In 't Veen, H A C van Helvoort, A J van 't Hul

{"title":"Reliability of 24-h measurement of physical activity, sleep, and sedentary time in adult patients with asthma using a triaxial accelerometer.","authors":"S M J Janssen, M A Spruit, R S Djamin, J C C M In 't Veen, H A C van Helvoort, A J van 't Hul","doi":"10.1080/02770903.2024.2420758","DOIUrl":"10.1080/02770903.2024.2420758","url":null,"abstract":"Objective: Physical activity (PA), sleep, and sedentary time (SST) are important outcomes to monitor and to improve as part of patients' asthma management. This study aimed to assess the number of measurement days needed to reliably measure PA and SST. Secondly, the influence of external factors on the reliability of measuring PA and SST was studied.Methods: Adult patients with stable asthma were asked to wear a triaxial accelerometer for at least four days, with at least 22.5 h of wear time per day. The Intraclass Correlation Coefficients (ICCs) between different number of measurement days were used to determine reliability. Values ≥0.75 indicated good reliability.Results: Data from 452 patients were analyzed (63% women; age: 49 ± 16 years; FEV1: 87 ± 17% predicted). PA could reliably be measured with four valid measurement days (ICC 0.761). For SST, three days were needed (ICC 0.778). In summer and autumn, three days were needed to reliably measure PA, in winter four, in spring six. For SST, five days were needed in spring for good reliability, and two in all other seasons.Conclusion: Based on data from four valid days, PA and SST can reliably be measured with an accelerometer in patients with asthma. Seasonal influences are present, especially during spring. When measuring for four days, using only weekdays or three weekdays and one weekend day is recommended. The degree of asthma control, dyspnea or spirometric values did not influence the reliability.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"566-576"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achieving clinical remission in asthma with mepolizumab: a subanalysis on vitamin D as a predictor of response. "使用美妥珠单抗使哮喘临床缓解：维生素 D 作为反应预测因子的子分析"。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 Epub Date: 2024-11-01 DOI: 10.1080/02770903.2024.2419435

Ravi Shekhar Jha

{"title":"Achieving clinical remission in asthma with mepolizumab: a subanalysis on vitamin D as a predictor of response.","authors":"Ravi Shekhar Jha","doi":"10.1080/02770903.2024.2419435","DOIUrl":"10.1080/02770903.2024.2419435","url":null,"abstract":"Objective: Mepolizumab, an anti-IL-5 monoclonal antibody, has shown promise in reducing exacerbations and steroid dependency in severe eosinophilic asthma. This study aims to evaluate the effectiveness of mepolizumab in achieving clinical remission in asthma over 12 months and explore Vitamin D levels as a predictor of response.Method: We assessed Asthma Control Questionnaire (ACQ) scores, spirometry, number of exacerbations, oral corticosteroid (OCS) use, and inhaled corticosteroid (ICS) use in 32 patients, observing significant clinical improvements. Data were collected 1 year prior to starting mepolizumab and one year after starting mepolizumab. Nasal polyps were not seen in all the patients, and computed tomography of para-nasal sinuses are not available for all the patients, so nasal polyps status are not evaluated to avoid any bias.Result: Our results indicate that 12 patients achieved clinical remission after starting mepolizumab, with a strong correlation between higher Vitamin D levels and positive treatment outcomes. This suggests that optimizing Vitamin D levels could enhance the response to mepolizumab in asthma patients, and help in achieving better asthma control.Conclusion: Mepolizumab is an effective treatment for severe eosinophilic asthma, significantly improving clinical outcomes and reducing corticosteroid use. This study highlights the importance of Vitamin D as a predictor of response to mepolizumab, suggesting that higher Vitamin D levels may enhance treatment efficacy.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"549-553"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast-food consumption and asthma-related emergency room visits in California. 加利福尼亚州快餐消费与哮喘相关急诊就诊率。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 Epub Date: 2024-11-19 DOI: 10.1080/02770903.2024.2429679

Kimberly Valle, Marcela Entwistle, Asa Bradman, Paul Brown, Emanuel Alcala, Ricardo Cisneros

{"title":"Fast-food consumption and asthma-related emergency room visits in California.","authors":"Kimberly Valle, Marcela Entwistle, Asa Bradman, Paul Brown, Emanuel Alcala, Ricardo Cisneros","doi":"10.1080/02770903.2024.2429679","DOIUrl":"10.1080/02770903.2024.2429679","url":null,"abstract":"Introduction: Asthma is common, affecting up to 8% of adults in the United States. Several studies have shown an association between poorer diet and asthma. Despite the prevalence of fast-food consumption in the Western diet, research examining fast food consumption and asthma is limited.Objective: This study aimed to examine the association between fast food consumption and asthma-related emergency room visits among adults with asthma in California from 2011-2016.Methods: This cross-sectional study focused on 11,561 adults with asthma in California. Publicly available data from the California Health Interview Survey was used. The independent variable included fast food consumption, and the dependent variable was emergency room visits due to asthma. This study used logistic regression models and controlled for sex, race, self-reported overall health, BMI, and current smoking status. Survey weights were applied to ensure the analysis represented the general population.Results: Consumption of fast food ≥3 times per week was associated with increased odds of emergency room visits for asthma among adults with asthma in California (unadjusted model: OR = 1.64 CI: 1.13-2.40, p = 0.01; adjusted model: ORadj =1.53, CI: 1.03-2.26, p = 0.03).Conclusion: Our findings suggest that high consumption of fast food among adults with asthma may result in higher odds of asthma-related emergency room visits. Thus, decreasing fast food consumption may benefit adults with asthma by reducing emergency room visits.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"647-654"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating the cost of asthma: moderating effect of race/ethnicity on the relationship between asthma severity and the direct cost. 估算哮喘的成本：种族/族裔对哮喘严重程度与直接成本之间关系的调节作用。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 Epub Date: 2024-11-13 DOI: 10.1080/02770903.2024.2424306

Yonsu Kim, Ji Won Yoo, Sheniz Moonie, Tae-Ha Chung, Soumya Upadhyay, Rumy Lee

{"title":"Estimating the cost of asthma: moderating effect of race/ethnicity on the relationship between asthma severity and the direct cost.","authors":"Yonsu Kim, Ji Won Yoo, Sheniz Moonie, Tae-Ha Chung, Soumya Upadhyay, Rumy Lee","doi":"10.1080/02770903.2024.2424306","DOIUrl":"10.1080/02770903.2024.2424306","url":null,"abstract":"Objective: Marginalized racial/ethnic populations showed higher rates of asthma prevalence and high-cost healthcare utilization for asthma. However, few studies investigated the disproportionate financial burden of asthma among the underrepresented racial/ethnic groups. This study aims to estimate the direct cost of asthma by severity and race/ethnicity and examine the moderating effects of race/ethnicity on the relationship between asthma severity and the cost.Methods: This study employs a retrospective study design to estimate the direct cost of asthma for hospitalizations, ED visits, and outpatient visits. Nevada claims data were used from Q4 2015 to Q4 2021. Generalized linear models (GLMs) were used to estimate the direct cost of asthma and test the moderating effects of race/ethnicity.Results: The direct cost increased as asthma severity intensified across the three settings. The direct cost rose from $42148 (Hospitalizations), $4291 (ED visits), and $2177 (Outpatient visits) among those with mild asthma to $60464, $10857, and $7116 among those with severe asthma. The direct cost increased if patients were older, African Americans, or diagnosed with severe asthma. The incremental cost was greater among African American and Asian patients for ED visits, indicating the moderating effect of race/ethnicity.Conclusions: We found an incremental cost for severe asthma and the moderating effect of race/ethnicity on the relationship between asthma severity and the cost of ED and outpatient visits. The higher incremental costs among marginalized racial/ethnic groups imply that the financial burden of asthma increases on a larger scale among those racial/ethnic groups than among White patients.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"600-607"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Arabic version of the Asthma Trigger Inventory among asthmatic pediatric patients in Saudi Arabia. 沙特阿拉伯哮喘儿科患者哮喘触发量表阿拉伯语版的评估。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.1080/02770903.2024.2426005

Mohammed M Alyami, Ahmed H Alasimi, Abdullah A Alqarni, Musaad J Alghamdi, Fahad H Balharith, Abdulelah M Aldhahir

{"title":"Evaluation of the Arabic version of the Asthma Trigger Inventory among asthmatic pediatric patients in Saudi Arabia.","authors":"Mohammed M Alyami, Ahmed H Alasimi, Abdullah A Alqarni, Musaad J Alghamdi, Fahad H Balharith, Abdulelah M Aldhahir","doi":"10.1080/02770903.2024.2426005","DOIUrl":"10.1080/02770903.2024.2426005","url":null,"abstract":"Background: Asthma Trigger Inventory (ATI) is available in English, German, and Spanish languages; however, a version in Arabic language specifically tailored for identifying asthma triggers within Saudi Arabia has been missing.Objectives: To assess the reliability and validity of the adapted Arabic ATI among parents of asthmatic children in Saudi Arabia.Methods: A cross-cultural adaptation of the ATI was conducted, adding seven region-specific triggers to reflect cultural and environmental factors. The Pediatric Asthma Quality of Life Questionnaire (PACQLQ) was used to assess quality of life. Construct validity of the Arabic ATI was evaluated via exploratory factor analysis (EFA), and reliability was measured with Cronbach's alpha.Results: EFA yielded a KMO of 0.634 and a significant Bartlett's Test (χ2 = 10,005.076, p < 0.001). Six trigger subscales showed high reliability (α > 0.90), though Middle Eastern triggers had lower internal consistency (α = -0.11). Physical and psychological triggers correlated significantly with poorer quality of life (exercise: r = -0.662, p < 0.001; psychological: r = -0.307, p < 0.001). Air pollution and Middle Eastern triggers correlated positively with quality of life (r = 0.222, p < 0.001 and r = 0.245, p < 0.001).Conclusion: The Arabic version of the ATI exhibited robust reliability and validity when administered to parents of asthmatic children in Saudi Arabia. Additional research is warranted to further validate its applicability across various Arabic-speaking populations.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"628-636"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe asthma exacerbations associated with unconventional natural gas development activity in area of concentrated development. 在集中开发地区，非常规天然气开发活动与严重哮喘发作有关。

IF 1.7 4区医学

Journal of Asthma Pub Date : 2025-04-01 DOI: 10.1080/02770903.2025.2483000

Jeanine M Buchanich, Ada O Youk, Jennifer Fedor, Michael Lann, Nicholas R Tedesco, Evelyn O Talbott, Maureen Lichtveld, James P Fabisiak, Sally Wenzel

{"title":"Severe asthma exacerbations associated with unconventional natural gas development activity in area of concentrated development.","authors":"Jeanine M Buchanich, Ada O Youk, Jennifer Fedor, Michael Lann, Nicholas R Tedesco, Evelyn O Talbott, Maureen Lichtveld, James P Fabisiak, Sally Wenzel","doi":"10.1080/02770903.2025.2483000","DOIUrl":"10.1080/02770903.2025.2483000","url":null,"abstract":"Introduction: Residential proximity to unconventional natural gas development (UNGD) has been shown to be associated with asthma exacerbations, but there is limited evidence regarding whether exacerbations are associated with a particular distance or phase of well activity.Objective: To study the impact of proximity to UNGD activity by well phase and buffer distance.Methods: We included asthma patients 5-90 years old with a primary diagnosis of asthma and at least one order for medications prescribed for asthma residing in one of eight Southwestern Pennsylvania counties between 2011 and 2020. We matched events (severe exacerbation, emergency department visit, hospitalization) by age group, sex, and year to cohort members without an event of the same or greater severity. The primary exposure measure was an inverse distance-weighted index of UNGD activity up to 10 miles of a patient's residence. We fit a series of adjusted multilevel logistic regression models using tertiles of exposure activity by well phase and buffer distance.Results: Our cohort consisted of 46,676 asthma patients. We found strong evidence for an increased risk specifically during the production phase for all buffer distances examined for all three event types, as based on consistent, statistically significantly elevated odds ratios. Elevations ranged from 2 to 8 times the baseline of no wells within 10 miles of the patient's residence.Conclusion: This study provides evidence of increased risk of asthma events with the production phase. This should be considered in determining risk communication and assessment for these vulnerable populations, particularly during the production phase.","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0