Journal of Asthma最新文献

{"title":"The assessment of exhaled nitric oxide in patients with obesity and asthma before and after exercise.","authors":"Burcu Parlak, Zeynep Ülker Tamay Altinel, Nermin Güler","doi":"10.1080/02770903.2025.2453507","DOIUrl":"10.1080/02770903.2025.2453507","url":null,"abstract":"<p><strong>Objective: </strong>It is well-known that children who suffer from obesity and asthma may also have exercise-induced bronchospasm. Exhaled nitric oxide is an indicator of airway inflammation, and could be affected by exercise. This study looked at how exercise, which is a typical cause of acute airway obstruction, affects the levels of FeNO and spirometric parameters in obese and asthmatic children.</p><p><strong>Materials and methods: </strong>Seventy children between the ages of 6 and 18 were divided into four groups: healthy children, obese children with asthma, obese children without asthma, and normal-weight asthmatic children. FeNO and spirometric parameters were assessed before and after exercise. Their heart rate was raised to 160-170 beats per minute by walking on a flat surface.</p><p><strong>Results: </strong>The highest mean FeNO was seen in the asthmatic-obese group, while the lowest mean FeNO was found in the healthy group. MEF25-75 increased with exercise in the obese non-asthmatic group. FEV1/FVC was the lowest in the asthmatic-obese group.</p><p><strong>Conclusions: </strong>FeNO and FEV1/FVC have a strong association with asthma. The highest values of FeNO found in asthma-obesity combined. It was seen that obesity increased inflammation but exercise did not affect FeNO values. FeNO and FEV1 values were found to be higher in obese patients with and without asthma than normal weight and overweight asthmatics and non-asthmatics.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1013-1019"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world mepolizumab treatment in patients with severe asthma decreased exacerbations, oral corticosteroid use, and healthcare resource utilization and costs over 4 years: a retrospective analysis.","authors":"Wendy C Moore, Alexandra Stach-Klysh, Thomas Corbridge, Elizabeth Packnett, Donna McMorrow, Megan Richards, Arijita Deb","doi":"10.1080/02770903.2025.2450640","DOIUrl":"10.1080/02770903.2025.2450640","url":null,"abstract":"<p><strong>Objective: </strong>Although the efficacy of mepolizumab in reducing exacerbations and oral corticosteroid (OCS) use in severe asthma is well-established, real-world long-term effectiveness data are limited. This study evaluated the real-world impact of mepolizumab treatment in patients with severe asthma over a 4-year follow-up period.</p><p><strong>Methods: </strong>This was a retrospective cohort study of patients with asthma initiating mepolizumab (index date: first claim, November 2015-September 2019) using the Merative MarketScan Commercial and Medicare Databases. Outcomes included asthma exacerbations, OCS use, and exacerbation-related healthcare resource utilization (HCRU) and costs, assessed 12-months pre-index (baseline) and annually during the 4-year follow-up period.</p><p><strong>Results: </strong>Among 189 eligible patients, mean asthma exacerbation rate (AER) declined progressively from baseline during follow-up: AER decreased by 53.8% at Year 1 and 73.8% by Year 4 (<i>p</i> < 0.001). The annual OCS prescription rate reduced from baseline by 41.1% at Year 1 and 62.2% at Year 4 (<i>p</i> < 0.001). The proportion of patients with both no exacerbations and no OCS use progressively increased from 6.4% at baseline to 18.5% at Year 1 and 41.8% at Year 4. Exacerbation-related HCRU including inpatient, emergency room, and outpatient office visits decreased from baseline (9.0%, 21.7%, and 78.8%, respectively), at Year 1 (3.2%, 12.2%, and 49.2%), and Year 4 (0.0%, 4.8%, and 31.8%). Exacerbation-related healthcare costs declined from $4,635 at baseline to $1,487 at Year 1 and $217 at Year 4 (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Patients treated with mepolizumab demonstrated progressive and sustained long-term, real-world reductions in exacerbation frequency, OCS dependency, and exacerbation-related HCRU and costs over 4 years.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"984-996"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning models for preventative mobile health asthma control.","authors":"Alan Wong","doi":"10.1080/02770903.2025.2453812","DOIUrl":"10.1080/02770903.2025.2453812","url":null,"abstract":"<p><strong>Introduction: </strong>Asthma attacks are set off by triggers such as pollutants from the environment, respiratory viruses, physical activity and allergens. The aim of this research is to create a machine learning model using data from mobile health technology to predict and appropriately warn a patient to avoid such triggers.</p><p><strong>Methods: </strong>Lightweight machine learning models, XGBoost, Random Forest, and LightGBM were trained and tested on cleaned asthma data with a 70-30 train-test split. The models were measured on Precision Score, Accuracy Score, Recall Score, F1 Score and model speed.</p><p><strong>Results: </strong>The best model, XGBoost, obtained an Accuracy score of 0.902, Recall score of 0.904, Precision score of 0.835, and F1 score of 0.860 and a model training speed of 14 s.</p><p><strong>Conclusion: </strong>As proved by the XGBoost model, predicting asthma triggers can be a viable option for asthma control using machine learning. In addition, the actionable information of triggers, allows patients to make behavior changes. However there will still need to be work testing the system in a mobile health system.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1032-1040"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and system-level determinants of caregivers' quality of life among inner-city preschool children with asthma.","authors":"Olusegun Owotomo, Kristin A Riekert, Cynthia S Rand, Michelle N Eakin","doi":"10.1080/02770903.2025.2458516","DOIUrl":"10.1080/02770903.2025.2458516","url":null,"abstract":"<p><strong>Objective: </strong>Caregivers of children with asthma can become overwhelmed by the burden of care provision. Guided by the socioecological framework, we examined individual and system-level factors associated with caregiver health-related quality of life (HRQoL) among preschool children (aged two to six years) enrolled in a multilevel home- and school-based asthma educational intervention in Baltimore, Maryland.</p><p><strong>Methods: </strong>The primary outcome was caregiver HRQoL measured at baseline and six months. Independent variables were baseline individual-level factors (caregiver's health literacy, self-efficacy to manage asthma, and depressive symptoms) and system-level factors (barriers to asthma care measured in five subdomains-pragmatics, health knowledge and beliefs, expectations, skills, and marginalization-and neighborhood social cohesion). Multiple regression models were used to assess the association between baseline individual and system-level factors and caregiver HRQoL at baseline and six-month follow-up adjusting for the child's asthma control, caregiver's age, household income, and study arm assignment/intervention.</p><p><strong>Results: </strong>398 caregivers completed the baseline survey and 328 (82%) completed the six-month follow-up survey. In the adjusted multiple regression model, lower caregiver's health literacy and higher barriers to asthma care related to pragmatics were significantly associated with lower caregiver HRQoL at baseline (<i>b</i> = 0.38, 95% CI, 0.15-0.61, <i>p</i> = .002; and <i>b</i> = 0.01, 95% CI, 0.004-0.02, <i>p</i> < .001, respectively). The results were similar at the six-month follow-up.</p><p><strong>Conclusion: </strong>Caregiver health literacy and barriers to asthma care related to pragmatics and skills were found to be important determinants of asthma caregiver HRQoL. Addressing these factors may improve the quality of life among caregivers of preschool children with asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1061-1069"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography in severe asthma assessment: a systematic review.","authors":"Simona Luzzi, Tommaso Pianigiani, Akter Dilroba, Martina Meocci, Elisa Salvadori, Benedetta Picchi, Vittoria Ventura, Sara Croce, Laura Bergantini, Miriana D'Alessandro, Elena Bargagli, Paolo Cameli","doi":"10.1080/02770903.2025.2460549","DOIUrl":"10.1080/02770903.2025.2460549","url":null,"abstract":"<p><strong>Objective: </strong>Chest computed tomography (CT) is usually performed in patients with severe asthma (SA) to exclude concomitant conditions related to poor clinical control. Despite the growing evidence regarding the utility of CT in the characterization of morphological abnormalities and airway remodeling, its role in SA assessment is still largely unexplored. The aim of our systematic review was to evaluate published data investigating the role of chest CT in patients with SA.</p><p><strong>Data sources: </strong>The systematic search was conducted on the Medline database through the Pubmed search engine.</p><p><strong>Study selections: </strong>A total of 53 studies has been included.</p><p><strong>Results: </strong>Quantitative CT (qCT) parameters generally differ between SA patients compared to mild to moderate asthmatic patients or healthy controls and are related to functional decline. CT parameters allow to identify image-based clusters reflecting remodeling patterns and/or air trapping features. The detection of mucus plugs is more frequent in severe eosinophilic asthma, and it is related to marked airway obstruction and ventilation defects. Benralizumab treatment appears to reduce or vanish mucus plugging. Most studies regarding CT and bronchial thermoplasty (BT) detect the usefulness of this investigation in predicting treatment response. Lastly, conflicting results surround the relation between chest CT and SA assessment in children due to also the scarcity of studies focusing on pediatric population.</p><p><strong>Conclusions: </strong>The role of CT scans in SA is still debated. Most studies focus on the identification of CT-derived disease clusters while studies primarily evaluating the predicting role of CT scan to different biologics are lacking and could represent an interesting research area.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"919-928"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody response to SARS-CoV-2 vaccine in patients with asthma.","authors":"Xiaoqin Zhang, Yifei Tao, Zhu Song, Lina Sun, Yongchang Sun, Rong Jin, Chun Chang","doi":"10.1080/02770903.2025.2458523","DOIUrl":"10.1080/02770903.2025.2458523","url":null,"abstract":"<p><strong>Background: </strong>Viral infections constitute a primary trigger for asthma exacerbations. While vaccines protect against viral infections by eliciting a Th1 immune response, the impact of the asthmatic immune milieu which is characterized by Th2 cytokine dominance and elevated IgE levels on post-vaccination antibody production remains elusive. Therefore, vaccination protocols tailored to asthma patients need to be formulated.</p><p><strong>Methods: </strong>The levels of IgG specific for SARS-CoV-2 S protein were measured in the sera of vaccinated and unvaccinated individuals by ELISA. The differences in antibody titers between asthma patients and healthy controls, as well as among distinct asthma subgroups were analyzed.</p><p><strong>Results: </strong>The vaccinated individuals had significantly elevated serum antibody levels compared to their unvaccinated counterparts. There were no significant differences in the antibody titers of asthma patients and healthy controls after completion of the three-dose vaccination regimen. Furthermore, no discernible variations in antibody titers were detected among the asthma subgroups.</p><p><strong>Conclusion: </strong>Asthma patients can safely adhere to the same vaccination strategies as the general healthy population, negating the need for any specialized vaccination protocols based solely on the asthmatic immune landscape.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1082-1091"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing ChatGPT's accuracy and reliability in asthma general knowledge: implications for artificial intelligence use in public health education.","authors":"Muhammad Thesa Ghozali","doi":"10.1080/02770903.2025.2450482","DOIUrl":"10.1080/02770903.2025.2450482","url":null,"abstract":"<p><strong>Background: </strong>Integrating Artificial Intelligence (AI) into public health education represents a pivotal advancement in medical knowledge dissemination, particularly for chronic diseases such as asthma. This study assesses the accuracy and comprehensiveness of ChatGPT, a conversational AI model, in providing asthma-related information.</p><p><strong>Methods: </strong>Employing a rigorous mixed-methods approach, healthcare professionals evaluated ChatGPT's responses to the Asthma General Knowledge Questionnaire for Adults (AGKQA), a standardized instrument covering various asthma-related topics. Responses were graded for accuracy and completeness and analyzed using statistical tests to assess reproducibility and consistency.</p><p><strong>Results: </strong>ChatGPT showed notable proficiency in conveying asthma knowledge, with flawless success in the etiology and pathophysiology categories and substantial accuracy in medication information (70%). However, limitations were noted in medication-related responses, where mixed accuracy (30%) highlights the need for further refinement of ChatGPT's capabilities to ensure reliability in critical areas of asthma education. Reproducibility analysis demonstrated a consistent 100% rate across all categories, affirming ChatGPT's reliability in delivering uniform information. Statistical analyses further underscored ChatGPT's stability and reliability.</p><p><strong>Conclusion: </strong>These findings underscore ChatGPT's promise as a valuable educational tool for asthma while emphasizing the necessity of ongoing improvements to address observed limitations, particularly regarding medication-related information.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"975-983"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns and trends in burden of asthma and its attributable risk factors from 1990 to 2021 among South Asian countries: a systematic analysis for the Global Burden of Disease Study 2021.","authors":"Akashanand, Mahalaqua Nazli Khatib, Ashok Kumar Balaraman, R Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G V Siva Prasad, Pranchal Rajput, Teena Vishwakarma, Sonam Puri, Puneet Tyagi, Ganesh Bushi, Nagavalli Chilakam, Sakshi Pandey, Megha Jagga, Rachana Mehta, Sanjit Sah, Muhammed Shabil, Abhay M Gaidhane, Diptismita Jena","doi":"10.1080/02770903.2025.2453810","DOIUrl":"10.1080/02770903.2025.2453810","url":null,"abstract":"<p><strong>Objective: </strong>Asthma poses a significant health burden in South Asia, with increasing incidence and mortality despite a global decline in age-standardized prevalence rates. This study aims to analyze asthma trends from 1990 to 2021, focusing on prevalence, incidence, mortality, and disability-adjusted life years (DALYs) across South Asia. The study also assesses the impact of risk factors like high body mass index (BMI), smoking, and occupational exposures on asthma outcomes.</p><p><strong>Method: </strong>We extracted asthma data from the Global Burden of Disease database for South Asia (1990-2021). Joinpoint regression analysis was used to assess temporal trends in asthma burden. Total Percentage change (TPC) in age-standardized rates of incidence, mortality, and DALYs were calculated. Data were stratified by gender, and the contribution of risk factors was evaluated.</p><p><strong>Results: </strong>Asthma-related mortality in South Asia decreased by 37%, from 27.78 per 100,000 (1990) to 17.54 per 100,000 (2021). The Maldives showed the most significant reduction in mortality (78.31%), while Bangladesh recorded a 47.44% reduction in prevalence and a 62.64% decrease in DALYs. High BMI, smoking, and environmental risks contributed significantly to DALYs, with environmental factors playing a major role in countries like Afghanistan (20.73%) and Bhutan (18.58%). Females, particularly those over 20, experienced higher asthma-related DALYs than males.</p><p><strong>Conclusion: </strong>Asthma burden in South Asia has reduced over the past three decades, yet the absolute number of cases continues to rise, driven by population growth and environmental risk factors. Targeted interventions addressing risk factors and healthcare disparities are essential for further reducing asthma burden.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1020-1031"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and regional mortality trends in patients with asthma in the United States (1999-2020): a CDC WONDER analysis.","authors":"Sophia Ahmed, Muhammad Asfandyar Nadir, Areej Iftikhar, Hamza Ashraf, Mohammad Ashraf","doi":"10.1080/02770903.2025.2458519","DOIUrl":"10.1080/02770903.2025.2458519","url":null,"abstract":"<p><strong>Objective: </strong>Around 7.7% of Americans have asthma, including 20.2 million adults and 4.6 million children. This study examines asthma mortality trends and disparities across U.S. demographic and geographic groups from 1999 to 2020.</p><p><strong>Methods: </strong>A retrospective analysis was conducted using the CDC WONDER database to examine asthma-related deaths in the U.S. from 1999 to 2020. Age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) per 100,000 were calculated. Trends and annual percent changes (APCs) were assessed overall and stratified by sex, race, region, and age.</p><p><strong>Results: </strong>From 1999 to 2020, the U.S. recorded 221 161 asthma-related deaths (AAMR: 3.07), mostly in medical facilities. Mortality declined from 1999 to 2018 (APC: -1.53%) but surged from 2018 to 2020 (APC: 28.63%). Females, NH Blacks, and NH American Indians had the highest mortality rates. Older adults (≥65) had the greatest burden, with younger groups showing notable increases post-2018. Rural areas and the West reported slightly higher rates than urban and other regions. Hawaii and the District of Columbia had the highest AAMRs, while Florida and Nevada had the lowest.</p><p><strong>Conclusion: </strong>Asthma-related mortality in the U.S. declined until 2018 but sharply increased from 2018 to 2020, with rises across all demographic groups, regions, and settings. Females, NH Blacks, and older adults consistently had higher mortality rates, while younger age groups showed recent alarming increases. Targeted interventions are urgently needed to address inequities and recent mortality surges.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1070-1081"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Asthma Exacerbations in Pediatric Emergency Departments Across the United States.","authors":"Melisa S Tanverdi, Isabella Zaniletti, Nidhya Navanandan, Isabel Hardee, Andrew H Liu, Rakesh D Mistry","doi":"10.1080/02770903.2025.2513056","DOIUrl":"https://doi.org/10.1080/02770903.2025.2513056","url":null,"abstract":"<p><strong>Objectives: </strong>There are 750,000 emergency department (ED) visits by children for asthma exacerbations in the United States annually. Despite changing evidence and epidemiology, there have not been recent assessments of acute asthma prevalence, management, and outcomes from pediatric EDs. This 40-center retrospective evaluation utilizes the Pediatric Hospital Information System to characterize pediatric ED asthma presentations from 2015-2020.</p><p><strong>Study design: </strong>Children 2-18 years with asthma ICD-9/10 code and receipt of albuterol were included. Demographics, Child Opportunity Index (COI), ED management, return visits, and adjusted costs were evaluated. Data were summarized using standard descriptive statistics and trends assessed using Mann-Kendall trend test.</p><p><strong>Results: </strong>There were 414,264 encounters made by 256,209 unique patients; 21% had >1 visit in 12 months. Median age was 6 years, 61.6% male, 44.5% Black, and 68.5% publicly insured; 58.3% of visits were by patients with very low/low COI. Systemic corticosteroids were administered in 86.3% of visits; 52.7% used dexamethasone. Chest radiographs were obtained in 23% of encounters. Most (74.9%) encounters resulted in ED discharge with a downward trend of visits for exacerbations per 1,000 ED visits of -9.77, 95% CI [-9.99,-9.54], increase in disposition to intensive care unit of 2.01 [1.87,2.41] and decrease in home/other of -3.77 [-4.34,-3.20]. There was no significant trend in return visits. Total adjusted costs were ∼$900 million.</p><p><strong>Conclusions: </strong>ED visits for asthma remain frequent and disproportionately affect children with lower social determinants of health. Dexamethasone has not been widely adopted as corticosteroid of choice and use of ancillary testing continues, highlighting opportunities for improvement in asthma care.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}