Journal of Asthma最新文献

{"title":"Exploring the mechanism of Zhichuanling oral liquid in treating childhood bronchial asthma based on network pharmacology and experimental verification.","authors":"Jiao Wang, Jiaxin Li, Xianhe Wang, Lihai Zhang, Qiuyan Liu, Duo Yang","doi":"10.1080/02770903.2026.2696579","DOIUrl":"10.1080/02770903.2026.2696579","url":null,"abstract":"<p><strong>Background: </strong>Bronchial asthma (BA), a common chronic airway inflammatory disease, significantly impairs lung function and quality of life due to pathological features such as airway remodeling, inflammatory imbalance, and oxidative damage. This study aimed to investigate the clinical efficacy of Zhichuanling Oral Liquid (ZCL) in children with BA and elucidate its mechanism of action through network pharmacology, animal experiments, and cellular studies.</p><p><strong>Methods: </strong>Sixty children with BA were randomly divided into a control group (conventional treatment) and an observation group (+ZCL). Clinical efficacy, lung function, and serum markers (IL-6, SAA, and IgE) were evaluated. Network pharmacology identified potential targets and pathways. An OVA-induced BA mouse model and cultured airway smooth muscle cells (ASMCs) were used to validate the mechanism.</p><p><strong>Results: </strong>Results showed ZCL significantly improved lung function (FVC, FEV1, and PEF), reduced symptom scores, and decreased IL-6, SAA, and IgE levels compared to control. Symptom relief times were shorter, and overall effective rate was higher (86.67% vs 60.00%). Network pharmacology revealed core targets (NFKB1, SIRT1, HIF1A, and MMP9) and component QCT, involving IL-17 pathway. In mice, ZCL reduced behavioral scores, IL-17, IL-4, MDA, and increased SOD, GSH-Px, alleviating airway inflammation. Medium-dose ZCL was most effective. In ASMCs, ZCL upregulated SIRT1, reduced NF-κB, IL-17, and oxidative stress, enhanced by SIRT1 overexpression.</p><p><strong>Conclusions: </strong>ZCL effectively treats childhood BA, as demonstrated by improvements in lung function and symptoms. Its mechanism is likely mediated by QCT regulating the SIRT1/NF-κB/IL-17 pathway to reduce airway inflammation and oxidative damage.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1583-1601"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-10 promoter polymorphisms (-1082G > A, -819C > T and - 592 C > A) and pediatric asthma susceptibility in a Mauritanian population.","authors":"Salka Boghale, Sondess Hadj Fredj, Yessine Amri, Mariem Sidatt, Sidi M Ghaber, Chayma Sahli, Siwar Chelbi, Rym Othmani, F Ouali, Rym Dabboubi, Taieb Messaoud","doi":"10.1080/02770903.2026.2696576","DOIUrl":"10.1080/02770903.2026.2696576","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-10 (IL-10) is a key immunoregulatory cytokine implicated in asthma pathogenesis. This case-control study investigated the association of three IL-10 promoter polymorphisms (-1082 G > A, -819 C > T, and -592 C > A) with asthma susceptibility and immune cell profiles in a Mauritanian pediatric population.</p><p><strong>Methods: </strong>Fifty-four asthmatic children and 45 controls were genotyped by PCR-RFLP and Sanger sequencing. Allele/genotype frequencies were compared by chi-square test, haplotypes by Haploview, and IgE, leukocyte, and platelet counts were analyzed using non-parametric tests.</p><p><strong>Results: </strong>The -592 C > A polymorphism was significantly associated with asthma, with the A allele more frequent in cases and the CA genotype increasing risk. The -1082 G > A polymorphism showed a significant genotype association, with the GA genotype protective and the AA genotype observed only in cases. The ACG haplotype showed a trend toward increased risk. Asthmatic children exhibited higher IgE levels, neutrophil and basophil percentages, and lower lymphocyte, monocyte, and platelet counts. The -1082 G > A variant was associated with neutrophils and monocytes in the overall population. Stratified analysis revealed disease-specific effects: -819 C > T influenced monocytes in cases, while -592 C > A affected eosinophils in controls.</p><p><strong>Conclusion: </strong>IL-10 promoter polymorphisms, particularly -592 C > A, are significantly associated with pediatric asthma susceptibility, with -1082 G > A showing an additional protective effect. Asthmatic children display a mixed inflammatory profile of elevated neutrophils and basophils alongside reduced lymphocytes and monocytes. The -1082 G > A, -819 C > T, and -592 C > A variants show immunomodulatory effects on leukocyte composition in a disease-context-dependent manner. Replication in larger cohorts with functional IL-10 measurements is warranted.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1541-1552"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heated high flow nasal cannula flow rates in critical pediatric asthma: an observational cohort study.","authors":"Sayantika Roy, Patrick T Wilson, Augusto A Litonjua, Michele E Smith","doi":"10.1080/02770903.2026.2696567","DOIUrl":"10.1080/02770903.2026.2696567","url":null,"abstract":"<p><strong>Objective: </strong>Heated high flow nasal cannula (HHFNC) use in pediatric critical asthma is rising despite concerns regarding its ability to effectively deliver nebulized medications to the lower airway. We aim to measure the association of low versus high HHFNC flow rates for delivery of continuously inhaled short acting beta agonist (cSABA) on clinical outcomes in the Pediatric Intensive Care Unit (PICU).</p><p><strong>Methods: </strong>This is a retrospective cohort study investigating PICU patients admitted with critical asthma who were prescribed HHFNC for cSABA delivery. Patients were divided into two groups based on the average flow rate used to deliver cSABA: low flow (≤5 L/min) versus high flow (>5 L/min). Outcomes, including total duration of cSABA, total duration of noninvasive respiratory support (HHFNC, continuous (CPAP) and bilevel (BPAP) positive airway pressure), PICU LOS, and hospital LOS were explored. Data was analyzed by Wilcoxon-Rank Sum, Chi-squared and Fisher's Exact tests.</p><p><strong>Results: </strong>112 patients were included. Patients in the low flow group (<i>n</i> = 56) had a median HHFNC flow rate of 4.0 L/min (IQR 3.9-4.0) versus patients in the high flow group (<i>n</i> = 56) at 9.6 L/min (IQR 7.0-15.0; <i>p</i> < 0.001). Pediatric Asthma Severity Scores (PASS) were similar (<i>p</i> = 0.095). The low flow group had significantly shorter total duration of cSABA (<i>p</i> = 0.048), shorter duration of noninvasive respiratory support (<i>p</i> = 0.0234), and shorter PICU (<i>p</i> < 0.001) and hospital (<i>p</i> = 0.0063) LOS.</p><p><strong>Conclusions: </strong>Low HHFNC flow rates for cSABA delivery are associated with shorter durations of cSABA, noninvasive respiratory support, PICU and hospital LOS.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1496-1506"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased induced sputum ITGB5 expression was correlated with airway inflammation and lung function in asthma.","authors":"Yuxia Liang, Lingzi Lei, Lu Qin, Juan Xia, Lu Tang, Yuqing Mo, Lijuan Du","doi":"10.1080/02770903.2026.2696583","DOIUrl":"10.1080/02770903.2026.2696583","url":null,"abstract":"<p><strong>Background: </strong>ITGB5 encodes integrin subunit beta 5 of that has been implicated in the eosinophilic asthma phenotype. However, the secretory profile of ITGB5 in induced sputum and its clinical significance in asthma remains poorly understood.</p><p><strong>Objective: </strong>This study aimed to measure ITGB5 levels in induced sputum supernatant from asthma patients and investigate its potential clinical implications.</p><p><strong>Methods: </strong>We enrolled 78 participants (18 healthy controls and 60 asthma patients) and quantified ITGB5 protein levels in induced sputum supernatant using ELISA. Correlations between ITGB5 and inflammatory markers, as well as airway obstruction parameters, were analyzed. Subsequently, we performed comparative analyses to evaluate variations in inflammatory cytokines between high- and low-ITGB5 expression subgroups.</p><p><strong>Results: </strong>Induced sputum ITGB5 levels were significantly elevated in asthma patients and markedly increased following inhaled corticosteroid (ICS) treatment. ITGB5 levels showed positive correlations with Th2-associated cytokines (IL-4, IL-5, IL-13, IL-25, IL-33, and TSLP) and Th2 signature genes (SERPINB2, CLCA1, and POSTN). Notably, IL-5, FeNO, and POSTN were significantly higher in the high-ITGB5(<i>n</i> = 30) than the low- ITGB5 (<i>n</i> = 30) expression group. Furthermore, sputum ITGB5 levels were inversely associated with pulmonary function (FEV₁% pred, FVC% pred, MEF% pred, MEF₂₅% pred and MEF₅₀% pred).</p><p><strong>Conclusions: </strong>Increased sputum ITGB5 in asthma was positively associated with inflammatory mediators and negatively correlated with pulmonary function, suggesting that ITGB5 upregulation may be involved in airway inflammation and obstruction in asthma pathogenesis.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1619-1627"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TNFR2 overexpression ameliorates allergic airway inflammation and restores immune homeostasis associated with Hippo pathway modulation in an ovalbumin-induced allergic asthma mouse model.","authors":"Dong Lin, Seyan Yan, Guohua Weng","doi":"10.1080/02770903.2026.2696574","DOIUrl":"10.1080/02770903.2026.2696574","url":null,"abstract":"<p><strong>Objective: </strong>Asthma remains a major global health burden with limited therapeutic options. Tumor necrosis factor receptor 2 (TNFR2) has been implicated in immune regulation, we aimed to investigate its role and underlying mechanisms in asthma pathogenesis.</p><p><strong>Methods: </strong>An ovalbumin (OVA)-induced murine asthma model was established to investigate TNFR2 function. Recombinant adeno-associated virus serotype 9 vectors were administered three weeks prior to OVA sensitization to achieve prophylactic TNFR2 overexpression. Airway inflammation was assessed by histological staining and inflammation scoring. Bronchoalveolar lavage fluid was analyzed for inflammatory cell infiltration. Flow cytometry was employed to determine Th1/Th2 ratios in lymphoid tissues. Cytokine profiles were measured by ELISA. Western blotting and immunohistochemistry were conducted to evaluate Hippo signaling pathway activation.</p><p><strong>Results: </strong>TNFR2 protein expression was significantly downregulated in asthmatic lung tissues. TNFR2 overexpression markedly attenuated airway inflammation, reduced mucus production, and decreased plasma IgE levels. The treatment restored Th1/Th2 immune balance and modulated cytokine production. Mechanistically, TNFR2 overexpression was associated with altered phosphorylation status of large tumor suppressor kinase (LATS) and yes-associated protein (YAP), suggesting potential involvement of the Hippo signaling pathway.</p><p><strong>Conclusions: </strong>These findings demonstrate that prophylactic TNFR2 overexpression ameliorates allergic airway inflammation <i>via</i> immunomodulation, with concomitant modulation of immune responses and Hippo pathway activity, identifying TNFR2 as a potential therapeutic target for asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1531-1540"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the role of single-nucleotide polymorphisms of PTGS2 and IL17 gene with allergic asthma susceptibility in the Indian population.","authors":"Saheen Sultana, Indranil Ganai, Himani Biswas, Saibal Moitra, Sanjoy Podder","doi":"10.1080/02770903.2026.2696577","DOIUrl":"10.1080/02770903.2026.2696577","url":null,"abstract":"<p><p><b>Objective:</b> Asthma is a multifactorial chronic inflammatory airway disease influenced by complex interactions between genetic predisposition and environmental exposures. Polymorphisms in inflammatory pathway genes such as PTGS2 and IL17 may modulate immune regulation and allergic asthma susceptibility. However, evidence from Indian populations remains limited. This study investigated the association of PTGS2 rs5277, IL17A rs3804513, and IL17F rs763780 polymorphisms with allergic asthma susceptibility and disease-related phenotypes in a population from West Bengal, India.<b>Method:</b> This case-control study involved 975 clinically confirmed allergic asthma patients and 600 healthy controls. Allergic asthma diagnosis was established using spirometry following GINA guidelines and atopy was confirmed by skin prick testing. Total serum IgE levels were measured using enzyme immunoassay. Genotyping was performed by polymerase chain reaction based restriction fragment length polymorphism. Associations were assessed using chi-square analysis under different genetic models, and odds ratios with 95% confidence intervals were calculated.<b>Result:</b> Significant associations were observed for PTGS2 rs5277 and IL17F rs763780 polymorphisms with allergic asthma susceptibility. The rs5277 CC and rs763780 CC genotypes, as well as the corresponding C alleles, conferred increased allergic asthma risk. These risk genotypes were also associated with reduced FEV₁/FVC ratios and elevated total IgE levels among patients. In contrast, IL17A rs3804513 showed no significant association with allergic asthma. Environmental factors such as damp housing and urban residence further influenced pulmonary function in patients.<b>Conclusions:</b> These findings demonstrate that PTGS2 rs5277 and IL17F rs763780 polymorphisms are associated with impaired lung function and enhanced IgE-mediated responses among the population of West Bengal, India.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1553-1565"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond BMI: a three-dimensional integrative framework of morphology-metabolism-adipose inflammation for predicting obesity-related asthma.","authors":"Yuanyuan Ying, Yaqin Wang, Kaiwen Ni, Zhen Wang, Ruilin Chen","doi":"10.1080/02770903.2026.2696562","DOIUrl":"10.1080/02770903.2026.2696562","url":null,"abstract":"<p><strong>Objective: </strong>Body mass index (BMI) fails to distinguish fat from lean mass, capture fat distribution, or reflect metabolic dysfunction and adipose inflammation, limiting its utility in obesity-related asthma. A framework integrating morphological, metabolic, and inflammatory indicators may offer a more biologically relevant approach.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, and Web of Science up to April 10, 2026, including population-based studies, imaging/body composition analyses, and mechanistic studies reporting asthma risk, phenotypes, lung function, control, or exacerbations.</p><p><strong>Results: </strong>BMI alone insufficiently predicts asthma outcomes. Central and upper-body anthropometric indices (waist-to-height ratio, neck circumference, weight-adjusted waist index) show stronger, BMI-independent associations with asthma onset, poor control, and lung function decline. Body composition distinguishes fat versus lean mass effects; visceral adipose tissue and dysanapsis capture mechanical/developmental pathways. Metabolic abnormalities (dyslipidemia, small dense LDL, triglyceride-glucose index) correlate with airway resistance and exacerbation risk, often independent of total adiposity. Leptin is elevated and adiponectin (ADPN) reduced in asthma; the leptin/ADPN ratio and interleukin-6 identify a metabolically driven, non-type 2 phenotype poorly captured by BMI. These three dimensions offer complementary biomarkers for risk stratification, phenotyping, and monitoring treatment response.</p><p><strong>Conclusions: </strong>Assessing obesity-related asthma should move beyond a BMI-centered approach toward an integrated morphology-metabolism-inflammation framework, enhancing early identification, endotype-based stratification, and personalized management. Longitudinal studies are needed to validate multi-indicator scoring systems and establish standardized cutoffs.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1399-1417"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148351993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of biologic therapy on ICS/LABA adherence in severe asthma: assessment of inhaler therapy adherence remains imperative.","authors":"L Bult, S van Deelen, M S van Daalen, B W A van Deurzen, G J Braunstahl, E C Vasbinder, J C C M In 't Veen","doi":"10.1080/02770903.2026.2696582","DOIUrl":"10.1080/02770903.2026.2696582","url":null,"abstract":"<p><strong>Rationale: </strong>Poor adherence to inhaled corticosteroids (ICSs) is often overlooked in severe asthma (SA), yet remains critical for treatment success. This study assesses electronically measured ICS/long-acting-beta-agonist (LABA) adherence and inhalation technique after biologic initiation in SA patients.</p><p><strong>Methods: </strong>This study is a sub-study derived from the EXACT@home study, a prospective, single-center randomized control trial. ICS/LABA treatments for SA patients initiating biologic therapy were switched to BF-Digihaler (Teva^®), a digital inhaler containing budesonide/formoterol, to monitor adherence and technique over a 6-month period. Adequate adherence was defined as using the correct dosage and achieving adequate inhalation flow on ≥80% of days, excluding underuse and overuse.</p><p><strong>Results: </strong>Fourteen patients were included (mean age 54 ± 11 years; 35.7% female). Median weekly adherence was 100% [43-100%] at baseline (week 2) and decreased to 73% [40-100%] at follow-up (week 27) (<i>p</i> = 0.153). Four patients had a weekly adherence rate below 80% at baseline, and seven had a rate below 80% at follow-up. A decrease in adherence of ≥10% was observed in six patients. There was a significant positive correlation between adherence and ACQ at follow-up (Spearman's <i>ρ</i> = 0.698, <i>p</i> = 0.006). Decrease in adherence was primarily due to reduced medication use, rather than worsened inhalation technique.</p><p><strong>Conclusions: </strong>Even among patients with SA who have started biologic therapy, adherence to ICS/LABA is crucial in treatment optimization and may decrease over time. This highlights the importance of ongoing adherence monitoring and support following biologics initiation to ensure optimal asthma control in SA patients.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1611-1618"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of short-acting beta-2 agonists delivered by metered-dose inhaler with spacer versus nebulizer in acute asthma exacerbations: a systematic review and meta-analysis.","authors":"Judicael Adadja, Tarek Boumenna, Frederic Bergeron, Patrick Daigneault, Jason R Guertin, Simon Berthelot","doi":"10.1080/02770903.2026.2696575","DOIUrl":"10.1080/02770903.2026.2696575","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aimed to compare the clinical effectiveness of short-acting β₂-agonist (SABA) delivery <i>via</i> metered-dose inhaler with spacer versus nebulizer in patients with acute asthma exacerbations.</p><p><p>A comprehensive search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library from inception to July 14, 2025. Randomized controlled trials (RCTs) involving patients aged 2 years or older comparing SABA administration via metered-dose inhaler with spacer versus nebulizer were included. The primary outcome was hospital admission; secondary outcomes included length of stay, return visit within 72 h, peak expiratory flow, forced expiratory volume in one second, oxygen saturation, respiratory rate, heart rate, and tremor. Two reviewers independently selected studies, extracted data, and assessed risk of bias using the RoB 2 tool. Random-effects meta-analyses were conducted, with separate analyses for pediatric and adult populations. The certainty of evidence was assessed using the GRADE approach. The protocol was registered in PROSPERO (CRD42023445698).</p><p><strong>Results: </strong>Twenty RCTs (2235 participants) were included. No significant difference in hospital admission was observed overall (RR = 0.90; 95% CI [0.69 to 1.18]; I² = 0%), nor in adults, children, or severe exacerbations. Secondary outcomes showed no significant differences overall. In children, however, MDI with spacer was associated with shorter ED stays and a lower risk of tremor. Certainty of evidence ranged from moderate to very low.</p><p><strong>Conclusion: </strong>SABA delivery <i>via</i> MDI with spacer showed comparable clinical outcomes to nebulization for acute asthma exacerbations, with potential pediatric advantages in reducing ED length of stay and the risk of tremor.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1435-1450"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child asthma and parental mental health: exploring associations by parental sex.","authors":"Benjamin Zablotsky, Laryssa Mykyta, Jonaki Bose, Julie D Weeks","doi":"10.1080/02770903.2026.2666095","DOIUrl":"10.1080/02770903.2026.2666095","url":null,"abstract":"<p><strong>Objective: </strong>Childhood asthma is a chronic condition that can be controlled with treatment. However, parents of children with asthma may face stressors such as juggling work and asthma care responsibilities, including the unpredictability of acute episodes. The current study examines associations between child asthma and parental mental health by parental sex and explores whether these differences reflect established differences seen in depression and anxiety symptoms.</p><p><strong>Methods: </strong>Weighted pair data from the 2019-2023 National Health Interview Survey permitted separate analysis of mother-child and father-child pairs. Logistic regression models examined associations between current child asthma and episodes/attacks in the past 12 months among children with current asthma with reported feelings of parental anxiety and/or depression, controlling for sociodemographic characteristics.</p><p><strong>Results: </strong>Mothers living with a child with asthma were more likely to report feelings of anxiety and/or depression compared to mothers not living with a child with asthma (AOR = 1.99, 95% CI = 1.64-2.42). In addition, mothers living with a child with asthma who had an episode/attack in the past 12 months were more likely to report feelings of anxiety and/or depression than mothers living with a child with asthma without an episode/attack (AOR = 1.52, 95% CI = 1.06-2.19). Weaker and nonsignificant associations were found between feelings of anxiety and/or depression among fathers by child asthma status (AOR = 1.30, 95% CI = 0.95-1.79) and whether the child had an episode/attack in the past 12 months (AOR = 1.32, 95% CI = 0.69-2.52).</p><p><strong>Conclusions: </strong>The current study highlights a potential increased risk for anxiety and/or depression among mothers raising a child with asthma when compared to fathers.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1468-1478"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}