Jefferson Antonio Buendía, Diana Guerrero Patiño, Juan Antonio Buendia Sanchez
{"title":"孟鲁司特+丙酸氟替卡松与丙酸氟替卡松治疗儿童咳嗽变异性哮喘：成本-效用分析","authors":"Jefferson Antonio Buendía, Diana Guerrero Patiño, Juan Antonio Buendia Sanchez","doi":"10.1080/02770903.2025.2546348","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the cost-utility of Mon and Flu versus Flu monotherapy in children with CVA in Colombia.</p><p><strong>Materials: </strong>We simulated a hypothetical cohort of 10,000 pediatric patients diagnosed with CVA, reflecting the typical clinical profile in Colombia. Cost-effectiveness was evaluated at a willingness-to-pay (WTP) value of US$5180. This analysis used QALYs and costs from a third-payer perspective over a 5-year time horizon.</p><p><strong>Results: </strong>The combination of Mon and Flu is not cost-effective since the incremental cost-utility ratio is greater than the willingness to pay per QALY in Colombia (USD 55,547 vs. USD 5180). The cost of Mon has the greatest influence on cost effectiveness, if the cost per dose of Mon 5 mg is less than US$ 0.034, the combination of Mon and Flu will be cost-effective at WTP of US$ 5180.</p><p><strong>Conclusions: </strong>The combination of Mon and Flu is not cost-effective for the management of CVA in children in Colombia, given the current WTP threshold. To enhance the cost-effectiveness of this combination therapy, efforts should focus on reducing the price of Mon and further optimizing its clinical use.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1970-1977"},"PeriodicalIF":1.3000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: cost-utility analysis.\",\"authors\":\"Jefferson Antonio Buendía, Diana Guerrero Patiño, Juan Antonio Buendia Sanchez\",\"doi\":\"10.1080/02770903.2025.2546348\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aims to evaluate the cost-utility of Mon and Flu versus Flu monotherapy in children with CVA in Colombia.</p><p><strong>Materials: </strong>We simulated a hypothetical cohort of 10,000 pediatric patients diagnosed with CVA, reflecting the typical clinical profile in Colombia. Cost-effectiveness was evaluated at a willingness-to-pay (WTP) value of US$5180. This analysis used QALYs and costs from a third-payer perspective over a 5-year time horizon.</p><p><strong>Results: </strong>The combination of Mon and Flu is not cost-effective since the incremental cost-utility ratio is greater than the willingness to pay per QALY in Colombia (USD 55,547 vs. USD 5180). The cost of Mon has the greatest influence on cost effectiveness, if the cost per dose of Mon 5 mg is less than US$ 0.034, the combination of Mon and Flu will be cost-effective at WTP of US$ 5180.</p><p><strong>Conclusions: </strong>The combination of Mon and Flu is not cost-effective for the management of CVA in children in Colombia, given the current WTP threshold. To enhance the cost-effectiveness of this combination therapy, efforts should focus on reducing the price of Mon and further optimizing its clinical use.</p>\",\"PeriodicalId\":15076,\"journal\":{\"name\":\"Journal of Asthma\",\"volume\":\" \",\"pages\":\"1970-1977\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asthma\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02770903.2025.2546348\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asthma","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02770903.2025.2546348","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
Montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: cost-utility analysis.
Objective: This study aims to evaluate the cost-utility of Mon and Flu versus Flu monotherapy in children with CVA in Colombia.
Materials: We simulated a hypothetical cohort of 10,000 pediatric patients diagnosed with CVA, reflecting the typical clinical profile in Colombia. Cost-effectiveness was evaluated at a willingness-to-pay (WTP) value of US$5180. This analysis used QALYs and costs from a third-payer perspective over a 5-year time horizon.
Results: The combination of Mon and Flu is not cost-effective since the incremental cost-utility ratio is greater than the willingness to pay per QALY in Colombia (USD 55,547 vs. USD 5180). The cost of Mon has the greatest influence on cost effectiveness, if the cost per dose of Mon 5 mg is less than US$ 0.034, the combination of Mon and Flu will be cost-effective at WTP of US$ 5180.
Conclusions: The combination of Mon and Flu is not cost-effective for the management of CVA in children in Colombia, given the current WTP threshold. To enhance the cost-effectiveness of this combination therapy, efforts should focus on reducing the price of Mon and further optimizing its clinical use.
期刊介绍：
Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.
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