{"title":"steroid-naïve成人支气管哮喘的小气道功能障碍:与嗜酸性粒细胞和非嗜酸性粒细胞表型相关。","authors":"Aditi Maheshwari, Sajal De","doi":"10.1080/02770903.2025.2552737","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Small airway dysfunction (SAD) is a common feature of bronchial asthma. However, its association with asthma phenotypes remains poorly understood. This study aimed to assess the prevalence of oscillometry-defined SAD in steroid-naïve adult bronchial asthma and to explore its association with asthma phenotypes based on peripheral blood eosinophil count (BEC).</p><p><strong>Methods: </strong>A total of 320 consecutive cases of bronchial asthma patients were enrolled. The severity of impairment in oscillometry parameters was expressed in <i>z</i>-scores. SAD in oscillometry was defined as R5-19 > upper limit of normal and/or X5 < lower limit of normal. The cohort was categorized into eosinophilic asthma (EA) and non-eosinophilic asthma (NEA) using a BEC cutoff of 300 cells/µL.</p><p><strong>Results: </strong>The mean age of the cohort was 37.5 ± 12.5 years, and 58.1% were male. The median BEC was 350 cells/µL. The mean FEV<sub>1</sub> was 66.7 ± 18.4 %predicted. Oscillometry-defined SAD was observed in 54.4% (95% CI: 48.1-59.4). Patients with SAD exhibited significantly lower spirometric indices compared to those without SAD. The proportion of EA was 58.4% (95% CI: 53.4-64.7). Spirometric parameters did not differ significantly between the EA and NEA. The severity of impairment in R5 and X5 was less in EA compared to NEA, though the difference was not statistically significant. The proportion of impaired R5-19 was significantly less in EA than NEA (47.6% vs. 57.9%; <i>p</i> = .04).</p><p><strong>Conclusions: </strong>Half of steroid-naïve bronchial asthma patients exhibited SAD at the time of diagnosis. NEA phenotypes are associated with higher impairment in oscillometry.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-7"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oscillometry-defined small airway dysfunction in steroid-naïve adult bronchial asthma: association with eosinophilic and non-eosinophilic phenotypes.\",\"authors\":\"Aditi Maheshwari, Sajal De\",\"doi\":\"10.1080/02770903.2025.2552737\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Small airway dysfunction (SAD) is a common feature of bronchial asthma. However, its association with asthma phenotypes remains poorly understood. This study aimed to assess the prevalence of oscillometry-defined SAD in steroid-naïve adult bronchial asthma and to explore its association with asthma phenotypes based on peripheral blood eosinophil count (BEC).</p><p><strong>Methods: </strong>A total of 320 consecutive cases of bronchial asthma patients were enrolled. The severity of impairment in oscillometry parameters was expressed in <i>z</i>-scores. SAD in oscillometry was defined as R5-19 > upper limit of normal and/or X5 < lower limit of normal. The cohort was categorized into eosinophilic asthma (EA) and non-eosinophilic asthma (NEA) using a BEC cutoff of 300 cells/µL.</p><p><strong>Results: </strong>The mean age of the cohort was 37.5 ± 12.5 years, and 58.1% were male. The median BEC was 350 cells/µL. The mean FEV<sub>1</sub> was 66.7 ± 18.4 %predicted. Oscillometry-defined SAD was observed in 54.4% (95% CI: 48.1-59.4). Patients with SAD exhibited significantly lower spirometric indices compared to those without SAD. The proportion of EA was 58.4% (95% CI: 53.4-64.7). Spirometric parameters did not differ significantly between the EA and NEA. The severity of impairment in R5 and X5 was less in EA compared to NEA, though the difference was not statistically significant. The proportion of impaired R5-19 was significantly less in EA than NEA (47.6% vs. 57.9%; <i>p</i> = .04).</p><p><strong>Conclusions: </strong>Half of steroid-naïve bronchial asthma patients exhibited SAD at the time of diagnosis. NEA phenotypes are associated with higher impairment in oscillometry.</p>\",\"PeriodicalId\":15076,\"journal\":{\"name\":\"Journal of Asthma\",\"volume\":\" \",\"pages\":\"1-7\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asthma\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02770903.2025.2552737\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asthma","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02770903.2025.2552737","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
摘要
目的:小气道功能障碍(SAD)是支气管哮喘的共同特征。然而,其与哮喘表型的关系仍然知之甚少。本研究旨在评估steroid-naïve成人支气管哮喘中振荡测量定义的SAD的患病率,并基于外周血嗜酸性粒细胞计数(BEC)探讨其与哮喘表型的关系。方法:选取320例支气管哮喘患者作为研究对象。振荡参数损伤的严重程度用z分数表示。结果:该队列患者平均年龄为37.5±12.5岁,男性占58.1%。中位BEC为350 cells/µL。平均FEV1为预测值66.7±18.4%。振荡测量定义的SAD发生率为54.4% (95% CI: 48.1-59.4)。与没有SAD的患者相比,SAD患者表现出明显较低的肺活量指数。EA占58.4% (95% CI: 53.4-64.7)。肺活量测定参数在EA和NEA之间无显著差异。EA患者R5和X5损伤程度较NEA患者轻,但差异无统计学意义。EA患者R5-19受损比例明显低于NEA患者(47.6% vs. 57.9%; p = 0.04)。结论:一半的steroid-naïve支气管哮喘患者在诊断时表现出SAD。NEA表型与较高的振荡测量损伤相关。
Oscillometry-defined small airway dysfunction in steroid-naïve adult bronchial asthma: association with eosinophilic and non-eosinophilic phenotypes.
Objective: Small airway dysfunction (SAD) is a common feature of bronchial asthma. However, its association with asthma phenotypes remains poorly understood. This study aimed to assess the prevalence of oscillometry-defined SAD in steroid-naïve adult bronchial asthma and to explore its association with asthma phenotypes based on peripheral blood eosinophil count (BEC).
Methods: A total of 320 consecutive cases of bronchial asthma patients were enrolled. The severity of impairment in oscillometry parameters was expressed in z-scores. SAD in oscillometry was defined as R5-19 > upper limit of normal and/or X5 < lower limit of normal. The cohort was categorized into eosinophilic asthma (EA) and non-eosinophilic asthma (NEA) using a BEC cutoff of 300 cells/µL.
Results: The mean age of the cohort was 37.5 ± 12.5 years, and 58.1% were male. The median BEC was 350 cells/µL. The mean FEV1 was 66.7 ± 18.4 %predicted. Oscillometry-defined SAD was observed in 54.4% (95% CI: 48.1-59.4). Patients with SAD exhibited significantly lower spirometric indices compared to those without SAD. The proportion of EA was 58.4% (95% CI: 53.4-64.7). Spirometric parameters did not differ significantly between the EA and NEA. The severity of impairment in R5 and X5 was less in EA compared to NEA, though the difference was not statistically significant. The proportion of impaired R5-19 was significantly less in EA than NEA (47.6% vs. 57.9%; p = .04).
Conclusions: Half of steroid-naïve bronchial asthma patients exhibited SAD at the time of diagnosis. NEA phenotypes are associated with higher impairment in oscillometry.
期刊介绍:
Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.