Association between dietary inflammatory index and asthmatic patients with sleep disorders in American adults, NHANES 2005-2020.

IF 1.3 4区 医学 Q3 ALLERGY
Journal of Asthma Pub Date : 2025-10-01 Epub Date: 2025-07-02 DOI:10.1080/02770903.2025.2526368
Zhouzhou Lu, Yujing Gu, Yun Zhao, Xiaoyi Shen, Honggan Wang, Jun Xie
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引用次数: 0

Abstract

Background: Chronic airway inflammation, recognized as the core pathological mechanism of asthma, may disrupt circadian rhythms through neuroimmune modulation mediated by inflammatory mediators. Emerging evidence suggests a markedly elevated prevalence of sleep disturbances among asthma patients, while dietary patterns modulating systemic inflammatory balance present feasible intervention targets. However, the association between Dietary Inflammatory Index (DII) and comorbid sleep disorders in asthma remains underexplored.

Method: This cross-sectional study analyzed data from 4,443 asthmatic adults with sleep disorders in NHANES (2005-2020). DII scores were calculated using 28 food parameters from two 24-h dietary recalls. Weighted multivariable logistic regression models were employed to examine DII-sleep disturbance associations with sequential adjustment for demographic, lifestyle, and clinical confounders. Restricted cubic spline (RCS) analysis evaluated nonlinear relationships and inflection points. Gender heterogeneity and subgroup interactions were assessed through stratified analyses.

Result: Multivariable analysis demonstrated significant dose-response relationships between elevated DII and sleep disturbance risk (P for trend <0.001). Participants in the highest DII quartile (Q4) demonstrated 47% increased risk compared to Q1 (OR:1.47, 95%CI:1.19-1.83). Full adjustment attenuated this association (Model 2 OR = 1.27, 0.99-1.62; p = 0.06), though borderline significance persisted (P for trend = 0.05). RCS analysis revealed a U-shaped nonlinear association (inflection point: DII = 1; p < 0.05) with significant gender heterogeneity. Males exhibited pronounced U-shaped trends (p < 0.05), contrasting with linear patterns in females (p > 0.05). Poverty-income ratio demonstrated significant interaction (p < 0.05), while other subgroups showed no significant interaction (p > 0.05).

Conclusion: The U-shaped DII-sleep disturbance underscores the critical importance of implementing anti-inflammatory dietary strategies in comprehensive asthma management.

膳食炎症指数与美国成人哮喘患者睡眠障碍的关系,NHANES 2005-2020。
背景:慢性气道炎症被认为是哮喘的核心病理机制,它可能通过炎症介质介导的神经免疫调节破坏昼夜节律。新出现的证据表明,哮喘患者中睡眠障碍的患病率明显升高,而饮食模式调节全身炎症平衡是可行的干预目标。然而,饮食炎症指数(DII)与哮喘共病睡眠障碍之间的关系仍未得到充分探讨。方法:本横断面研究分析了NHANES(2005-2020)中4443名患有睡眠障碍的哮喘成人的数据。使用两次24小时饮食回顾的28种食物参数计算DII评分。采用加权多变量logistic回归模型来检验dii -睡眠障碍与人口统计学、生活方式和临床混杂因素序贯调整的关系。限制三次样条(RCS)分析评估了非线性关系和拐点。通过分层分析评估性别异质性和亚组相互作用。结果:多变量分析显示,DII升高与睡眠障碍风险之间存在显著的剂量-反应关系(P为趋势0.05)。贫困收入比存在显著交互作用(p0.05)。结论:u型dii -睡眠障碍强调了在哮喘综合管理中实施抗炎饮食策略的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Asthma
Journal of Asthma 医学-过敏
CiteScore
4.00
自引率
5.30%
发文量
158
审稿时长
3-8 weeks
期刊介绍: Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.
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