Journal of Asthma最新文献

{"title":"Parental numeracy skills and asthma control: a cross-sectional study.","authors":"Walid Al-Qerem, Anan Jarab, Abdel Qader Al Bawab, Judith Eberhardt, Enas Al-Zayadnehe, Montaha Al-Iede, Maher Khdour, Lujain Al-Sa'di, Lama Sawaftah","doi":"10.1080/02770903.2025.2519100","DOIUrl":"10.1080/02770903.2025.2519100","url":null,"abstract":"<p><strong>Objective: </strong>Asthma is a common chronic condition among children globally, with increasing prevalence in Jordan. Effective asthma control depends on parental involvement, including numeracy skills, which influence medication management and symptom monitoring. This study investigated the association between parental numeracy and asthma control in Jordanian children.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 400 parents of children with asthma receiving treatment at the University of Jordan Hospital between February and May 2024. Participants were recruited from clinic waiting areas. Parental numeracy was assessed using the Arabic version of the Asthma Numeracy Questionnaire (Ar-ANQ). The sample included 59.5% male children (median age = 6 years; IQR: 3-11) and 54.1% female parents (median age = 37 years; IQR: 31-43).</p><p><strong>Results: </strong>Higher parental numeracy scores were significantly associated with better asthma control (Coefficient = 0.236, 95% CI [0.056, 0.417], <i>p</i> = 0.01). Low monthly income and older parental age were negatively associated with asthma control (<i>p</i> = 0.034 and <i>p</i> = 0.004, respectively). Poor medication adherence also correlated with lower asthma control (<i>p</i> = 0.025).</p><p><strong>Conclusions: </strong>Parental numeracy significantly affects asthma control in children. Improving numeracy skills and medication adherence, especially in low-income families, could enhance asthma outcomes. Future research should explore long-term interventions to address these factors and improve asthma management in Jordan.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1768-1775"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome sequencing analysis identified an alternative splicing regulatory network mediated by RNA-binding proteins in asthma.","authors":"Jingyi Zhang, Mengqi Wang, Dongxiao Yu, Changjie Qu, Jialin Zhang, Huimin Lao","doi":"10.1080/02770903.2025.2526365","DOIUrl":"10.1080/02770903.2025.2526365","url":null,"abstract":"<p><strong>Background: </strong>Accelerated eosinophilic apoptosis is an important therapeutic strategy for bronchial asthma (BA).</p><p><strong>Objective: </strong>To further reveal the molecular mechanism.</p><p><strong>Methods: </strong>We selected RNA-seq data from cells in bronchoalveolar lavage fluid from patients with different severity levels. we performed principal component analysis (PCA) of the splicing ratios of differentially expressed genes (DEGs) between different samples. And we carried out overlapping analysis of DEGs in samples with known RBP genes. Then we analyzed the GO functions of the differentially expressed AS genes regulated by the differential expression of RBPs. We also analyzed the RBP-AS-GO network and analyzed RBPs and genes known to be involved in apoptosis and inflammation. Finally, we selected another set of data to verify the results.</p><p><strong>Results: </strong>we identified nine highly expressed alternative splicing events, among which A3SS and A5SS had the highest incidence. The incidence of these alternative splicing events (ASEs) is closely related to the severity of BA. And we identified nine important RNA-binding proteins (RBPs). We obtained some AS genes were enriched in apoptosis- and inflammation-related pathways. Then we analyzed RBPs and genes known to be involved in apoptosis and inflammation. The results revealed that the expression levels of the selected RBPs were consistent in the two datasets and that the rate of AS events in both genes was increased.</p><p><strong>Conclusion: </strong>We hypothesized that the regulation of AS by RBPs could affect apoptosis and inflammation in patients with severe asthma. We predicted that RBPs (PCBP4 and RPS29) and ASEs (A5SSs) are potential therapeutic targets for BA.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1798-1806"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High- <i>vs.</i> low-intensity inspiratory muscle training in asthma: effects on respiratory muscles, exercise performance, dyspnea, and health-related quality of life.","authors":"Cahidenur Kocak, Esra Pehlivan, Seyma Baslilar","doi":"10.1080/02770903.2025.2519103","DOIUrl":"10.1080/02770903.2025.2519103","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of high- and low-intensity Inspiratory Muscle Training (IMT) combined with standard pulmonary rehabilitation on respiratory muscle function, exercise capacity, dyspnea, and quality of life in asthmatic patients.</p><p><strong>Methods: </strong>Forty asthmatic patients were randomized into high-intensity IMT (H-IMT, <i>n</i> = 20) and low-intensity IMT (L-IMT, <i>n</i> = 20) groups. The H-IMT group trained at 80% of maximal inspiratory pressure and the L-IMT group at 30%, with 5% weekly load increases. Both groups followed an 8-week exercise program including breathing, strengthening, and walking exercises. Respiratory functions, pulmonary function test, respiratory muscle strength, maximum inspiratory and expiratory pressure measurement, peripheral muscle strength, 6-min walk test (6MWT), modified Medical Research Council (mMRC) dyspnea and Asthma Control Test (ACT), Asthma Quality of Life Questionnaire (AQLQ), Saint George Respiratory Quality of Life Questionnaire (SGRQ) and International Physical Activity Questionnaire (IPAQ) scores were assessed pre- and post-intervention.</p><p><strong>Results: </strong>Baseline characteristics were similar. Both groups improved in most outcomes except spirometric values. The L-IMT group showed significant gains in IPAQ-SF walking (<i>p</i> = .03) and total scores (<i>p</i> = .02). 6MWT distance, mMRC, and ACT scores improved significantly more in the H-IMT group compared to the L-IMT group. There was no statistically significant difference between the groups (<i>p</i> > 0.05). Similarly, when the groups were compared, AQLQ-Environmental, AQLQ-Total, SGRQ-Impact, SGRQ-Total scores showed more improvement in the H-IMT group.</p><p><strong>Conclusion: </strong>Both IMT intensities improved respiratory function, exercise capacity, and quality of life. High-intensity IMT was more effective for asthma control, while low-intensity IMT enhanced physical activity. Tailoring IMT intensity may optimize outcomes for asthmatic patients.</p><p><strong>Registration number: </strong>NCT06516848.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1776-1788"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stock inhalers in action: results of a pilot study across multiple Illinois counties.","authors":"Andrea A Pappalardo, Paige Hardy, Caroline Youssef, Lynn B Gerald, Molly A Martin","doi":"10.1080/02770903.2025.2519095","DOIUrl":"10.1080/02770903.2025.2519095","url":null,"abstract":"<p><strong>Objective: </strong>Pediatric asthma health disparities are common. Schools often lack asthma diagnostic information and infrastructure to handle asthma symptoms. Undesignated or stock rescue inhalers available to anyone in respiratory distress can help prevent absences.</p><p><strong>Methods: </strong>A stock inhaler pilot program was conceptualized and evaluated using implementation science frameworks. Districts from high-asthma-burden counties were engaged and offered guided implementation over the 2022-2023 or 2023-2024 school year. Districts were required to complete training and report stock inhaler incidents. Pre/post implementation interviews and surveys were performed to assess acceptability, feasibility, fidelity to emergency protocols, satisfaction, and utilization. Descriptive statistics were calculated for surveys and utilization data. Thematic data analysis was performed on interview transcripts.</p><p><strong>Results: </strong>Fourteen pilot schools from six districts served 10,265 children. Twenty-eight stock inhaler events were documented. The majority of children (75%) using the stock inhaler had known asthma. Of the 24 events for which disposition was reported, 12 students returned to class (50%), 10 left school with a parent (42%), and only two were transported by emergency services (8%). Pre-implementation interviews revealed that school nurses were concerned about family asthma education (76%) and staff training (29%). One interviewee described the program as \"a sturdy safety net… if you can't breathe, nothing else matters\". All schools intended to continue stocking inhalers.</p><p><strong>Conclusions: </strong>Stock inhaler programming was well received and improved student outcomes. Resources for Every School Confronting Unexpected Emergencies-Illinois (RESCUE-IL) secured state funding in Illinois to expand stock inhaler programming to over 80% of Illinois public schools. Multi-level, community-focused interventions can maximize the impact of health policies.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1752-1761"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of asthma exacerbations in pediatric emergency departments across the United States.","authors":"Melisa S Tanverdi, Isabella Zaniletti, Nidhya Navanandan, Isabel Hardee, Andrew H Liu, Rakesh D Mistry","doi":"10.1080/02770903.2025.2513056","DOIUrl":"10.1080/02770903.2025.2513056","url":null,"abstract":"<p><strong>Objectives: </strong>There are 750,000 emergency department (ED) visits by children for asthma exacerbations in the United States annually. Despite changing evidence and epidemiology, there have not been recent assessments of acute asthma prevalence, management, and outcomes from pediatric EDs. This 40-center retrospective evaluation utilizes the Pediatric Hospital Information System to characterize pediatric ED asthma presentations from 2015-2020.</p><p><strong>Study design: </strong>Children 2-18 years with asthma ICD-9/10 code and receipt of albuterol were included. Demographics, Child Opportunity Index (COI), ED management, return visits, and adjusted costs were evaluated. Data were summarized using standard descriptive statistics and trends assessed using Mann-Kendall trend test.</p><p><strong>Results: </strong>There were 414,264 encounters made by 256,209 unique patients; 21% had >1 visit in 12 months. Median age was 6 years, 61.6% male, 44.5% Black, and 68.5% publicly insured; 58.3% of visits were by patients with very low/low COI. Systemic corticosteroids were administered in 86.3% of visits; 52.7% used dexamethasone. Chest radiographs were obtained in 23% of encounters. Most (74.9%) encounters resulted in ED discharge with a downward trend of visits for exacerbations per 1,000 ED visits of -9.77, 95% CI [-9.99,-9.54], increase in disposition to intensive care unit of 2.01 [1.87,2.41] and decrease in home/other of -3.77 [-4.34,-3.20]. There was no significant trend in return visits. Total adjusted costs were ∼$900 million.</p><p><strong>Conclusions: </strong>ED visits for asthma remain frequent and disproportionately affect children with lower social determinants of health. Dexamethasone has not been widely adopted as corticosteroid of choice and use of ancillary testing continues, highlighting opportunities for improvement in asthma care.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1651-1655"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mepolizumab reduced healthcare resource utilization and improved work productivity in patients with severe asthma during the REALITI-A 2-year study.","authors":"Giorgio Walter Canonica, Arnaud Bourdin, Erika Penz, Lingjiao Zhang, Peter Howarth, Rafael Alfonso-Cristancho","doi":"10.1080/02770903.2025.2558755","DOIUrl":"10.1080/02770903.2025.2558755","url":null,"abstract":"<p><strong>Objective: </strong>To assess the real-world impact of mepolizumab on healthcare resource utilization (HCRU) and work productivity and activity impairment (WPAI) in patients with severe asthma.</p><p><strong>Methods: </strong>Asthma-related HCRU and WPAI were assessed over 2 years in the REALITI-A study-an international, prospective, observational cohort study in adults with severe asthma newly initiating mepolizumab (100 mg subcutaneous). Secondary endpoints of the study compared the proportion of patients with HCRU use, HCRU events, and WPAI component scores 12 months before mepolizumab initiation with 24 months follow-up. The relative rates of HCRU outcomes were calculated, with a treatment policy estimand for discontinuation.</p><p><strong>Results: </strong>Patients (<i>N</i> = 822) had a mean age of 54 years and 63% were female. Hospitalization rates were reduced by 53% in the 0-12-month follow-up period (<i>p</i> < 0.001) and sustained for 24 months. The rates of asthma-related hospitalizations, emergency department visits, and outpatient visits reduced by 59-64% (<i>p</i> < 0.001) across the 24-month follow-up. The mean number of overnight hospital stays reduced from 2.4 in the pre-treatment period to 1.0 and 0.5 in the 0-12-month and 12-24-month follow-up periods, respectively. The WPAI Asthma activity impairment score was reduced from baseline by 47% and 55% at 12 and 24 months of follow-up. Overall work impairment was reduced by 62% and 74%.</p><p><strong>Conclusions: </strong>Mepolizumab treatment reduced HCRU while improving activity and productivity in patients with severe asthma over 2 years. These data provide further evidence of real-world benefits of mepolizumab and may help inform healthcare system resource allocation.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement properties of the Patient-Specific Functional Scale in individuals with asthma.","authors":"Stephany Costa Franco, Luan Dos Santos Mendes-Costa, Gabriela Bezerra de Almeida, Isabella de Melo Matos, Simone Castelo Branco Fortaleza, Felipe V C Machado, Rafael Mesquita","doi":"10.1080/02770903.2025.2562580","DOIUrl":"10.1080/02770903.2025.2562580","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the reliability, construct and content validity, ceiling and floor effects, acceptability, and feasibility of the Patient-Specific Functional Scale (PSFS) in individuals with asthma.</p><p><strong>Methods: </strong>This methodological study included individuals with asthma. Sociodemographic and clinical characteristics, lung function (forced expiratory volume in one second - FEV₁), asthma control, and quality of life (Asthma Quality of Life Questionnaire - AQLQ) were assessed, in addition to the administration of the PSFS. Reliability, construct, and content validity, as well as ceiling/floor effects, were analyzed.</p><p><strong>Results: </strong>One hundred participants were evaluated (88% women, mean age 56 ± 14 years), the mean PSFS score was 4.1 ± 2.3. Regarding reliability, the intraclass correlation coefficient was 0.95 (95% confidence interval (CI): 0.88-0.97, <i>p</i> < .0001). The PSFS showed a fair correlation with the AQLQ activity limitation domain (<i>r</i> = 0.34, <i>p</i> = .001) and a weak correlation with FEV₁ (<i>r</i> = 0.16, <i>p</i> = .19). Lower scores were observed in participants with poorer asthma control (<i>p</i> = .03). Ninety-seven percent of the activities reported in the PSFS were classified under the Activity and Participation domain of the International Classification of Functioning, Disability, and Health (ICF). No ceiling or floor effects were detected.</p><p><strong>Conclusions: </strong>The PSFS demonstrated strong reliability, adequate validity, and no ceiling or floor effects, supporting its potential as a useful tool for assessing activity limitations in asthma.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of psychological support and respiratory function training in alleviating anxiety and improving lung function in patients with bronchial asthma.","authors":"Xiaofang Lin, Caiping Tan","doi":"10.1080/02770903.2025.2562572","DOIUrl":"10.1080/02770903.2025.2562572","url":null,"abstract":"<p><strong>Objective: </strong>Patients with bronchial asthma often experience anxiety in addition to decreased lung function.</p><p><strong>Method: </strong>This study retrospectively enrolled 204 diagnosed and hospitalized patients with bronchial asthma in our hospital, and randomly divided them into the observation group and the control group. Firstly, the differences in baseline data between two groups of patients were analyzed. Secondly, the differences in anxiety scores (GAD-7, HADS), Peak Expiratory Flow (PEF) levels, and nursing satisfaction between two groups of patients were analyzed at 1 week, 1 month, and 3 months after nursing intervention. Finally, the generalized estimation equation is applied to analyze the interaction between nursing intervention and time.</p><p><strong>Result: </strong>There were no significant differences between the observation group and the control group in most baseline indicators, such as age and gender. At 1 week, 1 month, and 3 months after intervention, the GAD-7 and HADS levels in the intervention group were significantly lower than those in the control group, while the PEF level and patient satisfaction were significantly higher than those in the control group. Over time, GAD-7 and HADS significantly decrease, while PEF and satisfaction (<i>p</i> < 0.001) significantly increase. The interaction showed that psychological support and respiratory function training significantly reduced anxiety levels at 1 and 3 months after intervention (GAD-7: <i>p</i> = 0.032; HADS: <i>p</i> = 0.002), significantly increased PEF levels at 1 week and 1 month after intervention (<i>p</i> < 0.001), and significantly improved satisfaction levels at 3 months after intervention (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Psychological support combined with respiratory function training can significantly reduce anxiety levels in patients with bronchial asthma and improve lung function.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postural balance and falls in older adults with asthma: a controlled cross-sectional study with follow-up.","authors":"Bruhna Schwambach, Fabiano Francisco de Lima, Patrícia Puccetti Pires, Rosana Câmara Agondi, Regina Maria Carvalho-Pinto, Celso R F Carvalho","doi":"10.1080/02770903.2025.2558760","DOIUrl":"10.1080/02770903.2025.2558760","url":null,"abstract":"<p><strong>Background: </strong>Postural balance is impaired in adults with asthma; however, this remains poorly understood in older people with asthma.</p><p><strong>Objective: </strong>To assess postural balance and the incidence of falls in older individuals with moderate to severe asthma.</p><p><strong>Methods: </strong>A controlled cross-sectional study with follow-up included individuals aged 65-80 years (asthma group, AG; <i>n</i> = 26) and without asthma (control group, CG; <i>n</i> = 27). The control group was matched by sex, age, and body mass index (BMI). The evaluations included comorbidities, fear of falling, muscle strength, and postural balance in different conditions. Subsequently, individuals received a fall diary and were followed up for six months.</p><p><strong>Results: </strong>AG had more comorbidities, greater fear of falling, and consumed more medications (<i>p</i> < 0.005). AG also had worse postural balance assessed by the Mini-BESTest compared to the CG (23 [18.0-25.0] <i>vs.</i> 24 [21.00-26.00] score; <i>p</i> = 0.03). AG showed a greater CoP oscillation than CG at rest in natural base without foam (1.22 [0.78-1.94] <i>vs.</i> 0.88 [0.64-1.37] cm²; <i>p</i> = 0.04) and at semi-tandem, post-exertion with foam (3.56 [2.59-6.57] <i>vs.</i> 2.54 [1.94-3.42] cm², <i>p</i> = 0.006). No between-group difference was observed in the predicted quadriceps and ankle dorsiflexor muscle strength (<i>p</i> > 0.05). Despite greater fear of falling and poorer balance, no group difference was observed in fall incidence over 6 months (8 <i>vs.</i> 10 falls), which may be partially explained by the follow-up period and the characteristics of the control group.</p><p><strong>Conclusion: </strong>Our findings partially support the study hypothesis. Older adults with asthma exhibit impaired balance and an increased fear of falling, but this does not necessarily translate into a higher incidence of falls.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Uncontrolled Asthma in a Pediatric Population with Severe Asthma: FRAMAG Study.","authors":"Elida Duenas-Meza, Sarah Pulido-Fentanes, Monica Mendez-Moreno, Nadia Juliana Proaños-Jurado","doi":"10.1080/02770903.2025.2562583","DOIUrl":"https://doi.org/10.1080/02770903.2025.2562583","url":null,"abstract":"<p><p>Severe asthma (SA) in children is associated with significant morbidity, increased healthcare utilization, and reduced quality of life. Despite appropriate treatment, achieving optimal asthma control remains challenging, particularly in pediatric populations. This study aimed to identify factors associated with poor asthma control in children with SA, focusing on clinical, functional, and caregiver-related variables. This retrospective cohort study included children aged 6-17 years with SA followed for up to three years in the Asmaire-Rexpira Program in Bogota, Colombia. Asthma control was defined using a comprehensive composite score integrating symptom questionnaires, exacerbation history, corticosteroid use, hospitalizations, and spirometry. Multivariable logistic regression was used to identify independent risk factors for uncontrolled asthma. Results: Of the 228 children included, 35.5% had uncontrolled asthma. Obstructive sleep apnea (OR: 2.16; 95% CI: 1.13-4.11; p = 0.019) and moderate to severe impairment in caregiver quality of life (OR: 12.35; 95% CI: 4.15-36.80; p < 0.001) were independently associated with uncontrolled asthma. Systemic corticosteroid use and hospitalization in the prior year were significantly more common in this group. Lung function was preserved in most children; however, those with uncontrolled asthma exhibited significantly greater bronchodilator reversibility (5.8% vs. 4.1%; p = 0.015) and higher functional variability over time based on conditional FEV₁ change scores (≥ +1.96 z-score in 18.9% vs. 8.5%). Conclusions: uncontrolled asthma in children with SA is associated with comorbid sleep apnea, caregiver burden, and functional variability despite normal spirometric values. These findings underscore the need for multidimensional evaluation, caregiver support, and longitudinal monitoring to optimize asthma control in high-risk pediatric populations.</p>","PeriodicalId":15076,"journal":{"name":"Journal of Asthma","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}