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A novel chassis for high-quality recombinant protein expression: apoptosis pathway engineering via multi-gene knockout and efficacy improvement of CHO cells. 高质量重组蛋白表达的新基础：通过多基因敲除的凋亡途径工程和CHO细胞效能的提高。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-21 DOI: 10.1186/s13036-026-00669-2
Youzhi Wu, Ying Cao, Zexuan Guo, Yanhua Ma, Xiaohui Zan, Xingjin Gu, Fan Zhang, Chunxia Chai, Rui Nui, Qiang Shang, Wei Wang
{"title":"A novel chassis for high-quality recombinant protein expression: apoptosis pathway engineering via multi-gene knockout and efficacy improvement of CHO cells.","authors":"Youzhi Wu, Ying Cao, Zexuan Guo, Yanhua Ma, Xiaohui Zan, Xingjin Gu, Fan Zhang, Chunxia Chai, Rui Nui, Qiang Shang, Wei Wang","doi":"10.1186/s13036-026-00669-2","DOIUrl":"10.1186/s13036-026-00669-2","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro electrical stimulation devices: practical framework for design, fabrication, and operation. 体外电刺激装置：设计、制造和操作的实用框架。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-20 DOI: 10.1186/s13036-026-00664-7
Gaurav Kulkarni, Jorge M Garcia, Miriam Isasi-Campillo, María Ujué González, Sahba Mobini
{"title":"In vitro electrical stimulation devices: practical framework for design, fabrication, and operation.","authors":"Gaurav Kulkarni, Jorge M Garcia, Miriam Isasi-Campillo, María Ujué González, Sahba Mobini","doi":"10.1186/s13036-026-00664-7","DOIUrl":"10.1186/s13036-026-00664-7","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are we there yet? The road to faster and more efficient CAR T cell manufacturing. 我们到了吗？通往更快更高效的CAR - T细胞制造之路。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-20 DOI: 10.1186/s13036-026-00666-5
Leonor N Matos, Margarida S Costa, Margarida Serra, Marta H G Costa
{"title":"Are we there yet? The road to faster and more efficient CAR T cell manufacturing.","authors":"Leonor N Matos, Margarida S Costa, Margarida Serra, Marta H G Costa","doi":"10.1186/s13036-026-00666-5","DOIUrl":"10.1186/s13036-026-00666-5","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosome-loaded hydrogels for bone regeneration: a cell-free therapeutic strategy. 外泌体负载水凝胶用于骨再生：一种无细胞治疗策略。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-19 DOI: 10.1186/s13036-026-00659-4
Shengyu Jin, Shicheng Zhou
{"title":"Exosome-loaded hydrogels for bone regeneration: a cell-free therapeutic strategy.","authors":"Shengyu Jin, Shicheng Zhou","doi":"10.1186/s13036-026-00659-4","DOIUrl":"10.1186/s13036-026-00659-4","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal deep learning for inflammatory bowel disease: a new frontier in cellular and molecular biomarker discovery to clinical translation. 炎症性肠病的多模式深度学习：细胞和分子生物标志物发现到临床转化的新前沿。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-19 DOI: 10.1186/s13036-026-00637-w
Peihong Li, Siqing Guo, Yikun Zhang, Hongyi Hu, TingJun Cheng, Bo Xu, Kexin Zeng, Tianjiao Huang, Zhi Dong, BenHuo, Jiang Lin, Hongzhu Wen, Boyun Sun
{"title":"Multimodal deep learning for inflammatory bowel disease: a new frontier in cellular and molecular biomarker discovery to clinical translation.","authors":"Peihong Li, Siqing Guo, Yikun Zhang, Hongyi Hu, TingJun Cheng, Bo Xu, Kexin Zeng, Tianjiao Huang, Zhi Dong, BenHuo, Jiang Lin, Hongzhu Wen, Boyun Sun","doi":"10.1186/s13036-026-00637-w","DOIUrl":"10.1186/s13036-026-00637-w","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":"20 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chitin nanowhiskers/octacalcium phosphate synergistically reinforced chitosan hydrogel for enhanced bone regeneration. 几丁质纳米晶须/磷酸八钙协同增强壳聚糖水凝胶促进骨再生。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-18 DOI: 10.1186/s13036-026-00647-8
Mingdong Yan, Yanjing Ou, Ruimin Liu, Changfu Xie, Jiang Chen
{"title":"Chitin nanowhiskers/octacalcium phosphate synergistically reinforced chitosan hydrogel for enhanced bone regeneration.","authors":"Mingdong Yan, Yanjing Ou, Ruimin Liu, Changfu Xie, Jiang Chen","doi":"10.1186/s13036-026-00647-8","DOIUrl":"10.1186/s13036-026-00647-8","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triphenylphosphine bromide enhances the effect of nano-micellar drug delivery system loaded with ROS inhibitor TEMPO on acute lung injury. 三苯基溴化膦增强了负载活性氧抑制剂TEMPO的纳米胶束给药系统对急性肺损伤的作用。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-17 DOI: 10.1186/s13036-026-00662-9
Jing Wang, Lisheng Xu, Wanrong Li, Fang Zhao, Yang Yang, Lingling Shan, Linyan Xin, Weiwei Wang
{"title":"Triphenylphosphine bromide enhances the effect of nano-micellar drug delivery system loaded with ROS inhibitor TEMPO on acute lung injury.","authors":"Jing Wang, Lisheng Xu, Wanrong Li, Fang Zhao, Yang Yang, Lingling Shan, Linyan Xin, Weiwei Wang","doi":"10.1186/s13036-026-00662-9","DOIUrl":"10.1186/s13036-026-00662-9","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A modular biodevice assembly tool kit for combinatorial screening and benchmarking multiple cell surface display platforms in Escherichia coli. 用于组合筛选和对大肠杆菌中多个细胞表面显示平台进行基准测试的模块化生物设备组装工具包。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-14 DOI: 10.1186/s13036-026-00660-x
Xiaoyue Xu, In-Geol Choi
{"title":"A modular biodevice assembly tool kit for combinatorial screening and benchmarking multiple cell surface display platforms in Escherichia coli.","authors":"Xiaoyue Xu, In-Geol Choi","doi":"10.1186/s13036-026-00660-x","DOIUrl":"10.1186/s13036-026-00660-x","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing red blood cell compatibility: in vitro hemagglutination prevention using a trispecific triabody as a blocking fragment for blood group antigens. 增强红细胞相容性：使用三特异性三体作为血型抗原阻断片段的体外血凝预防。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-13 DOI: 10.1186/s13036-026-00661-w
Saleha Hafeez, Muhammad Asghar
{"title":"Enhancing red blood cell compatibility: in vitro hemagglutination prevention using a trispecific triabody as a blocking fragment for blood group antigens.","authors":"Saleha Hafeez, Muhammad Asghar","doi":"10.1186/s13036-026-00661-w","DOIUrl":"10.1186/s13036-026-00661-w","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategic utilization of chicken bones immobilized by Aspergillus terreus for sustainable bioremediation of cobalt: statistical modeling, kinetics and thermodynamic studies. 土曲霉固定化鸡骨对钴可持续生物修复的战略利用：统计模型、动力学和热力学研究。
IF 6.5 3区 生物学
Journal of Biological Engineering Pub Date : 2026-03-11 DOI: 10.1186/s13036-025-00599-5
Marwa Eltarahony, Eman H El-Gamal, Moustafa M Salama, Amany Ibrahim
{"title":"Strategic utilization of chicken bones immobilized by Aspergillus terreus for sustainable bioremediation of cobalt: statistical modeling, kinetics and thermodynamic studies.","authors":"Marwa Eltarahony, Eman H El-Gamal, Moustafa M Salama, Amany Ibrahim","doi":"10.1186/s13036-025-00599-5","DOIUrl":"10.1186/s13036-025-00599-5","url":null,"abstract":"","PeriodicalId":15053,"journal":{"name":"Journal of Biological Engineering","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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