Journal of affective disorders最新文献

{"title":"Depolymerization of aquaporin-4 orthogonal array particles via the A25Q mutation does not cause behavioral deficits but confers resilience to chronic unpredictable mild stress.","authors":"Supratik Kundu, Yu Ai, Yue-Lin Huang, Jing-Cheng Lu, Tong Wu, Dan-Yue Shan, Yue Kong, Yi-Fan Zhao, Ao-Ran Sui, Dan-Dan Zhu, Tong-Hui Ma, Shao Li","doi":"10.1016/j.jad.2026.122376","DOIUrl":"10.1016/j.jad.2026.122376","url":null,"abstract":"<p><p>Aquaporin-4 (AQP4) formed orthogonal array particles (OAPs) is critical for brain water homeostasis and astrocytic function, but whether OAP structural integrity influences behavior or stress susceptibility is unknown. Using knock-in mice carrying the AQP4-A25Q mutation, which depolymerizes OAPs without altering AQP4 expression, we investigated baseline behavior and responses to chronic unpredictable mild stress (CUMS). Naïve AQP4-A25Q mice showed no anxiety- or depression-like behavior differences from wild-type (WT) mice, indicating OAP disassembly alone does not cause behavior deficit disorders. However, after CUMS, AQP4-A25Q mice exhibited significant resilience: reduced immobility in the tail suspension and forced swimming tests, preserved locomotor activity and central-zone exploration in the open field, and decreased anxiety-like responses in elevated plus maze compared to post stress WT mice. CUMS induced marked astrocytic (GFAP, S100β) and microglial (Iba-1, CD68) activation in WT hippocampus, but these responses were largely absent in mutants. Consistently, CUMS elevated pro-inflammatory cytokine (IL-1β, IL-6, TNF-α) in WT but not mutant mice. Although CUMS reduced the pAkt/Akt ratio in both genotypes, AQP4-A25Q mice maintained significantly higher pAkt levels after stress. Moreover, CUMS caused neuronal damage in WT hippocampus and cortex, whereas AQP4-A25Q mice were protected and even showed increased hippocampal neuronal density after stress. Collectively, OAP depolymerization does not intrinsically disrupt behavior but confers resilience to chronic stress by attenuating glial activation, neuroinflammation, and pAkt decline, preserving neuronal integrity. This identifies AQP4 OAP structure as a novel molecular determinant of stress susceptibility and highlights therapeutic potential for targeting OAP assembly in stress-related neuropsychiatric disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122376"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novelty seeking and rapid symptom improvement across active and sham accelerated iTBS conditions: A pooled individual-patient data analysis.","authors":"Cecilia Chiarenza, Beatriz Araújo Cavendish, Deng Mao, Yichen Zhang, Kevin La Monica, Guo-Rong Wu, Sara De Witte, Paula Horczak, Cisse Geleyn, Maria Salvina Signorelli, Carmen Concerto, Laís Boralli Razza, Chris Baeken","doi":"10.1016/j.jad.2026.122406","DOIUrl":"10.1016/j.jad.2026.122406","url":null,"abstract":"<p><strong>Introduction: </strong>Major depressive disorder (MDD) is highly prevalent and often treatment-resistant. Accelerated intermittent theta burst stimulation (aiTBS) is a promising intervention for treatment-resistant depression (TRD), though outcomes vary. Personality traits have been examined in relation to rTMS outcomes, yet their role in aiTBS remains underexplored. This pooled individual-patient-data analysis of two randomized, sham-controlled trials examined associations between baseline Temperament and Character Inventory (TCI) traits and one-week symptom change, and whether they differed by condition.</p><p><strong>Methods: </strong>The left dorsolateral prefrontal cortex was targeted for 20 sessions over 4 days. Personality was assessed with the TCI, depression severity with the 17-item Hamilton Depression Rating Scale (HDRS-17). TCI-symptom-change associations were examined with a robust linear mixed-effects model, adjusting for age, gender, repeated measurements, and study membership.</p><p><strong>Results: </strong>104 participants were included (M/F 45/59; mean age 40.9 ± 12.7; active/sham 50/54). The model yielded a Time × Novelty Seeking interaction (β = -1.70, p = 0.021): higher baseline Novelty Seeking was associated with faster symptom reduction, without a between-arm difference. However, the interaction did not survive Holm correction across 14 trait-interaction tests (adjusted p = 0.294) and is therefore exploratory. No other interaction reached the uncorrected threshold.</p><p><strong>Conclusions: </strong>Higher baseline Novelty Seeking showed a nominal association with faster symptom reduction, without a difference between active and sham conditions. Because it did not survive multiplicity correction and was not reproduced in within-arm analyses, it is preliminary and may reflect contextual or nonspecific processes. Independent replication is required before temperament assessment can be clinically informative.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122406"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained cognitive and functional effects of pro-cognitive interventions for bipolar disorder: A systematic review of randomised controlled trials.","authors":"Michail Kalfas, Anna Tröger, Elliot Hampsey, Rebecca Strawbridge, Kamilla W Miskowiak, Sameer Jauhar, Allan H Young, Dimosthenis Tsapekos","doi":"10.1016/j.jad.2026.122390","DOIUrl":"10.1016/j.jad.2026.122390","url":null,"abstract":"<p><p>A substantial proportion of individuals with bipolar disorder (BD) experience considerable cognitive deficits. Existing systematic reviews have evaluated the efficacy of pro-cognitive interventions in BD, but have not established whether any cognitive benefits translate into functional improvements, with evidence for sustained functional effects remaining limited. A systematic search was conducted on MEDLINE, EMBASE, PsycINFO and Cochrane Library from inception until 21 May 2026. Eligible studies were randomised controlled trials (RCTs) in BD reporting cognitive or functional outcomes at three or more months following a pro-cognitive intervention, or examining the translation of cognitive benefits into improvements in functional outcomes at any timepoint. Seven unique RCTs plus three secondary analyses of these trials (n = 615) met the inclusion criteria. Approximately 13% (7/55) of RCTs identified in the search of pro-cognitive interventions in adult BD assessed cognitive or functional outcomes at least 3 months after treatment end. Of the seven unique RCTs, most evaluated cognitive remediation (CR; k = 4). The average follow-up length was 4 months (range: 3-6 months). Three of the four RCTs examining CR reported cognitive benefits at 3 to 6 months, whereas only one CR RCT found consistent functional effects at 3 months. Evidence on the translation of cognitive benefits to functional improvements is scarce and inconsistent. Most trials examining pro-cognitive interventions do not examine whether potential benefits are sustained or whether they translate into improvements in real-world functioning. CR appears to be a promising intervention for achieving durable cognitive gains in BD, although evidence for sustained effects of other interventions is limited.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"414 ","pages":"122390"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dispositional optimism and pessimism on the relationship between stressful life events and late-life depression.","authors":"Greg Roebuck, Mojtaba Lotfaliany, James Whittaker, Malcolm Forbes, Mohammadreza Mohebbi, John J McNeil, Robyn L Woods, Alice J Owen, Stephanie A Ward, Rosanne Freak-Poli, Danijela Gasevic, Heather Craig, Chenglong Yu, Paul Lacaze, Jessica E Green, Richard A Kanaan, Michael Berk","doi":"10.1016/j.jad.2026.122359","DOIUrl":"10.1016/j.jad.2026.122359","url":null,"abstract":"<p><strong>Background: </strong>Dispositional optimism is associated with a lower risk of depression. Optimism may protect against depression by conferring resilience to stressful life events. This study aimed to investigate the effects of dispositional optimism, and the related trait of dispositional pessimism, on the relationship between stressors and depression in older adults.</p><p><strong>Methods: </strong>This prospective cohort study used data from the ASPREE Longitudinal Study of Older Persons. Participants were aged ≥70 years and without known cardiovascular disease, dementia, independence-limiting physical disability and depression. Optimism and pessimism were measured using the Life Orientation Test-Revised. Incident depression was defined as a score ≥ 8 on the 10-item Center for Epidemiological Studies Depression Scale. The experience of 10 different types of stressors was assessed.</p><p><strong>Findings: </strong>10,791 participants were followed for a median (IQR) period of 3.5 (2.8-5.0) years. After adjusting for sociodemographic, lifestyle and medical factors and genetic predisposition to depression (using a polygenic score), optimism was associated with a lower risk of depression (HR, 0.92; 95% CI 0.90-0.93). Pessimism (HR, 1.07; 95% CI 1.06-1.08) and stressful life events (HR, 1.17; 95% CI 1.14-1.21) were associated with a higher depression risk. Neither optimism nor pessimism was associated with differences in the strength of the relationship between stressors and depression (p ≥ 0.499).</p><p><strong>Conclusions: </strong>Optimism was associated with a lower risk of late-life depression. However, it was not associated with lower vulnerability to the depressogenic effects of stressful life events. These findings raise questions regarding whether optimism confers resilience to stressors in older adults.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122359"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive trajectories in the nine months following recent-onset major depressive disorder.","authors":"Alexandra Stainton, Caroline X Gao, Georgina D Thomas, Myriam Zhou, Robert Hester, Shayden Bryce, Katharine Chisholm, Siân Lowri Griffiths, Lana Kambeitz-Ilankovic, Julian Wenzel, Carolina Bonivento, Paolo Brambilla, Mariam Iqbal, Theresa K Lichtenstein, Marlene Rosen, Linda A Antonucci, Eleonora Maggioni, Joseph Kambeitz, Stefan Borgwardt, Anita Riecher-Rössler, Christina Andreou, André Schmidt, Frauke Schultze-Lutter, Eva Meisenzahl, Stephan Ruhrmann, Raimo K R Salokangas, Christos Pantelis, Rebekka Lencer, Olga Bienek, Georg Romer, Udo Dannlowski, Alessandro Bertolino, Rachel Upthegrove, Dominic B Dwyer, Nikolaos Koutsouleris, Stephen J Wood, Kelly Allott","doi":"10.1016/j.jad.2026.122371","DOIUrl":"10.1016/j.jad.2026.122371","url":null,"abstract":"<p><strong>Background: </strong>Specific cognitive difficulties are common in major depressive disorder, impacting functioning and quality of life. Yet, the timing of their emergence and longitudinal course remains poorly understood. This study aimed to characterise longitudinal cognitive functioning following recent onset depression and its association with changes in depressive symptoms.</p><p><strong>Methods: </strong>Longitudinal data from the PRONIA (Personalised Prognostic Tools for Early Psychosis Management) cohort recruited from ten European sites were used to evaluate trajectory differences between Healthy Controls (HC) and individuals experiencing recent onset depression (ROD). Linear mixed effect models were used with group-by-time interaction term for trajectory differences between baseline and nine-month follow-up, and the associations between changes in depression symptoms and cognitive functioning among ROD.</p><p><strong>Results: </strong>The sample comprised 420 participants (ROD, N = 151; HC, N = 269) aged 15-40 years (M = 25.4, SD = 6.1; 55% female). Two distinct group-level cognitive trajectories were observed. First, a similar trajectory (i.e., no difference) to HC in visual memory, attention span, verbal learning and memory, visuospatial working memory, emotion recognition, and processing speed. A stable deficit trajectory was observed in mental flexibility, auditory verbal working memory, phonetic and semantic verbal fluency among the ROD group. Analysis within ROD group suggested that these outcomes were unrelated to reductions in depressive symptoms. Changes in visual memory, visuospatial working memory, sustained attention, and processing speed were associated with changes in depressive symptoms, despite being unrelated to baseline variations in depressive symptoms, possibly suggesting a sensitivity to state effects of illness, regardless of baseline severity.</p><p><strong>Conclusions: </strong>Specific cognitive difficulties are already evident at the first depressive episode and may endure in the short-medium term, irrespective of depressive course. Tailored treatment addressing cognition should be provided early to promote cognitive health and functional recovery.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122371"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of H-coil TMS on suicidality in major depression: A secondary analysis of data from a multisite randomized trial comparing accelerated to once-a-day stimulation.","authors":"Yiftach Roth, Aron Tendler, Eliza Brink, Molly Davis, Aftab Khan, Timothy Prestley, Owen Muir, Carlene MacMillan, Aswin Kumar Mudunuru, M S Reddy, Samson Seplow, Russ Voltin, Daniel M Thistlethwaite, Colleen A Hanlon, Abraham Zangen","doi":"10.1016/j.jad.2026.122409","DOIUrl":"10.1016/j.jad.2026.122409","url":null,"abstract":"<p><p>Suicide is the 10th leading cause of death in US adults. Standard once-daily repetitive transcranial magnetic stimulation (rTMS) can reduce suicidal ideation. Yet, antidepressant and anti-suicidal effects often take several weeks to emerge, while rapid improvement is often required. Accelerated TMS has been proposed as a strategy to hasten therapeutic response. A recent FDA-regulated multicenter trial evaluated accelerated intermittent theta burst Deep TMS with the H1-coil versus standard high-frequency Deep TMS in MDD. Both groups demonstrated high remission and response rates for depression, with the accelerated protocol showing non-inferiority and a shorter time to remission. The goal of this exploratory secondary analysis was to evaluate the impact of these two H-coil TMS dosing paradigms on suicidal ideation. The Scale for Suicide Ideation (SSI), as well as suicidality items of HDRS, MADRS and CUDOS were collected and analyzed. On all scales, both accelerated and standard Deep TMS protocols were associated with meaningful reductions in suicidality. The accelerated protocol achieved a faster onset of improvement. Comparison between the timeline of improvement in suicidality and in overall depressive symptoms found a trend for faster improvement in suicidality, especially with the accelerated protocol. These findings highlight the importance of treatment frequency in determining time to clinical benefit and support the use of scalable accelerated protocols for patients requiring more rapid symptom relief.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122409"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antipsychotic medication and the prevention of psychiatric emergencies in difficult-to-treat adolescent depression.","authors":"Linnea Sepe-Forrest, Richard F Meraz, Zheng Chang, Michael D Morse, Tanya E Froehlich, Brian M D'Onofrio, Patrick D Quinn","doi":"10.1016/j.jad.2026.122386","DOIUrl":"10.1016/j.jad.2026.122386","url":null,"abstract":"<p><strong>Objectives: </strong>It is unclear how antipsychotic medications affect acute healthcare use among adolescents with depression. We compared risk of psychiatric emergencies between adolescents with difficult-to-treat depression initiating new antipsychotic versus antidepressant medications.</p><p><strong>Methods: </strong>This cohort study employed a target trial emulation framework using Optum's de-identified Clinformatics® Data Mart Database between 2009 and 2021. We compared risk of emergency visits or inpatient encounters with mental health diagnoses (i.e. psychiatric emergencies) following new atypical antipsychotic versus secondary antidepressant prescription fills among adolescents (10-19 years old) with depression. All adolescents had filled SSRI prescriptions within one year prior to initiating a secondary medication and had no FDA-approved indications for pediatric antipsychotic use.</p><p><strong>Results: </strong>Among youth with depression and SSRI receipt, there were 3710 incident antipsychotic users (63.7% female) and 28,527 secondary antidepressant users (71.7% female). Within 1 year of initiation, antipsychotic medications were associated with a higher risk of psychiatric emergencies (propensity-score weighted HR = 1.59; 95% CI = 1.46, 1.72) compared with secondary antidepressant medications. The weighted cumulative incidence of psychiatric emergencies was 38.7% (95% CI = 34.8%, 42.7%) for antipsychotic and 24.5% (95% CI = 23.7%, 25.3%) for secondary antidepressant users. Comparable results were observed for emergencies involving suicidality and in a series of sensitivity analyses.</p><p><strong>Conclusions: </strong>Our findings do not provide support for a protective effect of atypical antipsychotic medications compared with secondary antidepressant medications for the prevention of psychiatric emergencies in youth with difficult-to-treat depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122386"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Mapping heterogeneous predictors of problematic smartphone use in Chinese adolescents: A machine learning approach with a nationally representative sample\" [J. Affect. Disord. (2026) 410, 122007].","authors":"Shun Liu, Yuefa Lin, Wenpeng Hu, Yang Meng, Xiqin Liu","doi":"10.1016/j.jad.2026.122303","DOIUrl":"10.1016/j.jad.2026.122303","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122303"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of psychiatric medication on suicide reattempt risk in patients with depression: A retrospective cohort study using national health insurance data in Korea.","authors":"Jeong Hun Yang, Min Ji Kim, Sang Jin Rhee, Hyunju Lee, Youngdoe Kim, Bolam Lee, Yong Min Ahn","doi":"10.1016/j.jad.2026.122364","DOIUrl":"10.1016/j.jad.2026.122364","url":null,"abstract":"<p><strong>Background: </strong>This post-hoc analysis examined the effect of sustained psychiatric medication on suicide reattempt risk among Korean patients with depression following an initial attempt.</p><p><strong>Methods: </strong>Using the Korean Health Insurance Review and Assessment Service (HIRA) database, we identified adults aged 18 years and older diagnosed with depressive disorder who attempted suicide in 2014 (N = 4925; mean age 47.4 ± 17.3 years, range 19-96). Sustained psychiatric medication was defined as receiving antidepressant or antipsychotic treatment for ≥75% of the six months after the index attempt. Stabilized inverse-probability-of-treatment weighting (IPTW) based on propensity scores addressed baseline imbalances. Logistic regression assessed one-year reattempt risk; survival analyses examined long-term risk over up to seven years (from index through August 31, 2020; median follow-up 5.9 years, maximum 6.7 years). Exploratory subgroup analyses compared patients <65 and ≥ 65 years.</p><p><strong>Results: </strong>After IPTW, baseline characteristics were balanced. The one-year reattempt rate was 5.3% with medication versus 7.9% without (OR:0.65, 95% CI:0.504-0.846, P = 0.001). Survival analyses over the seven-year follow-up showed no significant long-term difference (IPTW-adjusted log-rank P = 0.886). The protective effect was evident only in patients <65 years (OR:0.621, 95% CI:0.471-0.822, P < 0.001), with no significant effect in those ≥65 years.</p><p><strong>Conclusions: </strong>Sustained psychiatric medication after a suicide attempt reduces one-year reattempt risk in patients with depression, in particular in those aged under 65 years. The benefit of initial treatment did not persist over seven years, suggesting that the effect of continued treatment beyond six months warrants future investigation.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122364"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prior reproductive and non-reproductive depression, and depressive symptoms in menopausal transition.","authors":"Marijn Schipper, Margot W L Morssinkhof, Dorenda K E van Dijken, Yadira Roggeveen, Birit F P Broekman","doi":"10.1016/j.jad.2026.122361","DOIUrl":"10.1016/j.jad.2026.122361","url":null,"abstract":"<p><strong>Objective: </strong>The menopausal transition is associated with an increased risk of depression. Prior depression is a well-established risk factor, but studies do not distinguish between prior reproductive and non-reproductive depression. We aimed to examine whether prior reproductive (i.e., premenstrual mood disorder and perinatal depression) and non-reproductive (i.e., not related to hormonal transitions) depression were differentially associated with depressive symptoms during the menopausal transition.</p><p><strong>Methods: </strong>We analyzed cross-sectional data from menopause outpatient clinics, including a multidisciplinary clinic. Exposures included premenstrual mood disorder assessed with the Premenstrual Symptom Screening Tool, perinatal depression assessed with the Edinburgh Postnatal Depression Scale-Lifetime version, and prior non-reproductive depression recorded in medical records. Current depressive symptoms were measured with the Inventory of Depressive Symptomatology-Self Rated. We used univariable and multivariable linear regression models to examine associations; multivariable models accounted for overlap between exposures.</p><p><strong>Results: </strong>Among 180 participants (median age 51; 61% perimenopausal, 39% postmenopausal), premenstrual mood disorder showed the strongest association with depressive symptom severity (B = 9.0, 95% CI 5.1-12.9, p < 0.001), followed by perinatal depression (B = 7.8, 95% CI 3.4-12.1, p < 0.001) and prior non-reproductive depression (B = 4.7, 95% CI 0.7-8.7, p = 0.021). In multivariable analysis, only premenstrual mood disorder (B = 7.2, 95% CI 2.4-12.1, p = 0.0037) and perinatal depression (B = 5.7, 95% CI 1.2-10.1, p = 0.013) remained associated with depressive symptom severity.</p><p><strong>Conclusion: </strong>Prior reproductive depression, but not prior non-reproductive depression, was associated with greater depressive symptom severity during the menopausal transition. Histories of premenstrual mood disorder and/or perinatal depression may help identify individuals vulnerable to depressive symptoms during this period. Prospective studies in population-based samples are needed.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122361"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}