Journal of affective disorders最新文献

{"title":"Using natural language processing to identify patterns associated with depression, anxiety, and stress symptoms during the COVID-19 pandemic","authors":"Abigail Beech ,&nbsp;Haoxue Fan ,&nbsp;Jocelyn Shu ,&nbsp;Javiera Oyarzun ,&nbsp;Peter Nadel ,&nbsp;Olivia T. Karaman ,&nbsp;Sophia Vranos ,&nbsp;Elizabeth A. Phelps ,&nbsp;M. Alexandra Kredlow","doi":"10.1016/j.jad.2025.01.139","DOIUrl":"10.1016/j.jad.2025.01.139","url":null,"abstract":"<div><h3>Background</h3><div>Combining data-driven natural language processing techniques with traditional methods using predefined word lists may offer greater insights into the connections between language patterns and depression and anxiety symptoms, particularly within specific stressful contexts.</div></div><div><h3>Methods</h3><div>Between 2020 and 2021, 1106 participants wrote narrative responses describing their experiences during the COVID-19 pandemic and completed the Depression Anxiety Stress Scale-21 (DASS). We investigated language patterns associated with DASS symptoms using established categories from Linguistic Inquiry and Word Count (LIWC) and sentiment analysis, as well as exploratory natural language processing techniques. Finally, we constructed machine learning regression models in order to assess how much of the variance in DASS symptoms is related to language use.</div></div><div><h3>Results</h3><div>We found significant positive bivariate correlations between total DASS symptoms and hypothesized LIWC categories: first-person singular pronouns, absolute language, and negative emotion words. These results remained largely similar when using negative sentiment scores and when statistically controlling for gender, age, and education. Exploratory n-gram analyses also revealed new individual words and phrases correlated with total DASS symptoms. Lastly, our regression models demonstrated a significant association between language use and total DASS symptoms (<em>R</em>² = 0.36–0.62).</div></div><div><h3>Conclusions</h3><div>The current study is one of the first to examine associations between language use and DASS symptoms during the pandemic using both traditional and data-driven techniques. These results replicate and extend prior findings regarding negative emotion and absolute language and identify unique correlates of DASS symptoms during pandemic-related stress, contributing to the literature on language and mental health more broadly.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 113-121"},"PeriodicalIF":4.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A shotgun metagenomic study identified short-chain fatty acid-producing species and their functions in the gut microbiome of adults with depressive symptoms: Large-scale shotgun sequencing data of the gut microbiota using a cross-sectional design","authors":"Sun-Young Kim ,&nbsp;So-Youn Woo ,&nbsp;Hyung-Lae Kim ,&nbsp;Yoosoo Chang ,&nbsp;Seungho Ryu ,&nbsp;Han-Na Kim","doi":"10.1016/j.jad.2025.01.149","DOIUrl":"10.1016/j.jad.2025.01.149","url":null,"abstract":"<div><h3>Background</h3><div>The gut-brain axis is emerging as a novel mechanism to explain depressive disorders.</div></div><div><h3>Methods</h3><div>We performed shotgun metagenomic sequencing of stool samples obtained from 133 individuals with depression and 532 without depression. This study examined the taxonomy, functional pathways, and predicted metabolites profiles associated with depressive symptoms, using generalized linear models. To explore links between the taxonomic and functional pathway results, we compared the relative abundance of specific species contributing to pathways significantly associated with depressive symptoms.</div></div><div><h3>Results</h3><div>Taxonomic composition suggested a disruption in short-chain fatty acid (SCFA)-producing capacity of the gut microbiome in the depressed group. Pathways related to SCFA biosynthesis were also depleted in this group. <em>Faecalibacterium prausnitzii</em>, a well-known SCFA-producing bacterium, was significantly decreased in the depressed group and was identified as a major contributor to the depleted pathways. When inferring the metabolites related to depression from metagenomic data, higher levels of docosapentaenoic acid, stearoyl ethanolamide, putrescine, and bilirubin were more likely to be found in the depressed group.</div></div><div><h3>Conclusion</h3><div>The present findings highlight the altered gut microbiota and associated SCFA-related pathways in individuals with depression. The depletion of <em>F. prausnitzii</em> and its contribution to SCFA production suggest that it is a potential therapeutic target for depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 26-35"},"PeriodicalIF":4.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between depressive symptoms and premature death: An exploratory mediation analysis via mitochondrial function","authors":"Kun Lian ,&nbsp;Xi Zhang ,&nbsp;Chenglong Shi ,&nbsp;Wei Yang ,&nbsp;Xiufeng Xu","doi":"10.1016/j.jad.2025.01.135","DOIUrl":"10.1016/j.jad.2025.01.135","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a common mental health issue that can lead to various physical and psychological diseases. However, the relationship between depressive symptoms and premature death remains unclear.</div></div><div><h3>Methods</h3><div>In this study, we used data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 to assess the relationship between depressive symptoms and premature mortality and the potential influence of mitochondrial function on this relationship. The Patient Health Questionnaire-9 (PHQ-9) was used to assess the severity of depressive symptoms. Mortality data were obtained from the National Death Index (NDI). Mitochondrial function was assessed by measuring methylmalonic acid (MMA) levels. Multivariate logistic regression was used to assess the association between depressive symptoms and premature mortality, controlling for demographic, lifestyle, and disease-related factors. Restricted cubic splines were plotted, and propensity score matching (PSM) was used to create balanced groups. Finally, mediation analysis was performed to investigate the mediating role of MMA in the association between depressive symptoms and premature mortality.</div></div><div><h3>Results</h3><div>This study included a total of 6599 participants. The results showed a substantial positive association (odds ratio [OR] = 1.452; 95 % confidence interval [CI], 1.038–2.031; <em>p</em> &lt; 0.05) between depressive symptoms and premature mortality. The significance of this relationship was maintained after PSM analysis (OR = 2.370; 95 % CI, 1.749–3.212; <em>p</em> &lt; 0.01). Mediation analysis showed that MMA partially mediated this relationship, with a mediation proportion of 4.1 %.</div></div><div><h3>Conclusion</h3><div>This study indicates that depressive symptoms significantly increases the risk of premature death and mitochondrial dysfunction partially mediates this positive relationship. Additional prospective and experimental studies are warranted to verify these findings.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 373-379"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and potential pathology of Moyamoya disease combined with psychiatric disorders in Chinese population - A cross-sectional study.","authors":"Lei Cao, Eryong Liu, Xiaoli Yuan, Yang Dong, Bo Yang, Hongwei Li","doi":"10.1016/j.jad.2025.01.134","DOIUrl":"https://doi.org/10.1016/j.jad.2025.01.134","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to identify the clinical characteristics of Moyamoya disease (MMD) combined with psychiatric disorders and explore the potential pathogenesis.</p><p><strong>Material and methods: </strong>Psychiatric disorders between 88 MMD patients and 72 health controls were investigated using psychological testing scales. We subsequently analyzed the clinical features of 72 MMD patients with psychiatric comorbidities retrospectively. Finally, neurotransmitters analysis was conducted to further explore the pathogenesis.</p><p><strong>Results: </strong>Results of self-testing scales revealed a significantly higher susceptibility of psychiatric disorders in MMD patients. Compared with MMD group, clinical features of combined group demonstrated significant differences in age (51.3 ± 9.6 vs. 40.9 ± 10.4, p = 0.000), gender of female (68.1 % vs. 51.3 %, p = 0.018), duration time (33.3 ± 44.6mon vs. 8.1 ± 15.3mon, p = 0.000), cerebral infarction (55.2 % vs. 70.8 %, p = 0.025), initial type, Suzuki stage and mRS scores (p < 0.05). The perfusion results revealed significantly decreased time to peak in frontal parietal lobe (1854.14 ± 238.62 vs. 1242.79 ± 115.99, p = 0.025), temporal occipital lobe (1721.55 ± 245.15 vs. 1165.71 ± 111.55, p = 0.040), lateral ventricle (1840.03 ± 256.88 vs. 1221.95 ± 115.53, p = 0.028), and the cerebral blood volume of temporal occipital lobe was found significantly decreased (300.36 ± 34.93 vs. 403.23 ± 19.70, p = 0.026), and remarkable lower incidence of hyperperfusion syndrome and subdural effusion were demonstrated. Differential neurotransmitters of decreased 3-htdroxybutyric acid expression and increased sarcosine, tyrosine, betaine aldehyde chloride, kynurenic acid, glycine, succinic acid and lysine were identified in combined group.</p><p><strong>Conclusions: </strong>Patients of MMD combined with psychiatric disorders presented unique clinical characteristics. Neurotransmitters disorder may be involved in the pathogenesis. These results provided novel clinical management evidence and new insights in pathologic mechanism of MMD combined with psychiatric disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term exposure therapy outcome in phobia and the link with behavioral and neural indices of extinction learning","authors":"Jette H. de Vos ,&nbsp;Iris Lange ,&nbsp;Liesbet Goossens ,&nbsp;Nicole K. Leibold ,&nbsp;Klara de Cort ,&nbsp;Jindra Bakker ,&nbsp;Stijn Michielse ,&nbsp;Machteld Marcelis ,&nbsp;Jim van Os ,&nbsp;Therese van Amelsvoort ,&nbsp;David E.J. Linden ,&nbsp;Koen R.J. Schruers","doi":"10.1016/j.jad.2025.01.133","DOIUrl":"10.1016/j.jad.2025.01.133","url":null,"abstract":"<div><div>Extinction learning is regarded as a core mechanism underlying exposure therapy. Under this assumption, studies have looked at the predictive value of the extinction learning paradigm for exposure therapy outcomes. However, predicting factors of long-term exposure therapy success have not been established. Participants with a specific phobia (SP) for spiders were included in a double-blind randomized controlled trial. Participants were randomly assigned to receive exposure therapy (<em>n</em> = 25, 24 females) or an active control intervention, progressive muscle relaxation (PMR; <em>n</em> = 18, 15 females). Symptom levels were measured with the Fear of Spiders questionnaire (FSQ) at baseline (T0), after the intervention (T1), and at six- (T2) and twelve (T3) months follow-up. At baseline, participants completed a three-day fMRI fear conditioning, extinction learning, and extinction recall paradigm. Indices of extinction were defined as self-reported threat expectancy and fear, and neural activation during stimulus presentations and threat omission in the ventromedial prefrontal cortex and nucleus accumbens, based on prior data. Mixed model analysis revealed that the exposure therapy group had an overall stronger decrease in phobic symptoms over time than the PMR group (β = 10.95, <em>p</em> &lt; .001). However, none of the indices of extinction learning were predictive for FSQ scores after exposure therapy at the longest follow-up measurement (T3). In sum, the current results show the long-term effectiveness of a single session of exposure therapy for reducing a specific fear of spiders but no baseline characteristics were identified that predicted individual differences in exposure therapy success after one year.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 324-330"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left prefrontal intermittent theta-burst stimulation therapy for major depressive disorder: A real-world, multisite observational study in Japan","authors":"Yoshihiro Noda ,&nbsp;Ryota Osawa ,&nbsp;Yuya Takeda ,&nbsp;Kyoshiro Fujii ,&nbsp;Yuka Saijo ,&nbsp;Taku Kajiya ,&nbsp;Kana Takeishi ,&nbsp;Sotaro Moriyama ,&nbsp;Takashi Saeki ,&nbsp;Shinichiro Nakajima ,&nbsp;Ryosuke Kitahata","doi":"10.1016/j.jad.2025.01.131","DOIUrl":"10.1016/j.jad.2025.01.131","url":null,"abstract":"<div><h3>Background</h3><div>Although approved for treatment in 2018, the effectiveness of intermittent theta-burst stimulation (iTBS) in a real-world setting remains inadequately studied. This observational study investigated the real-world use of iTBS, a usual medical practice for depression, factors influencing its effectiveness, and differences in effectiveness between 600 and 1200 pulses.</div></div><div><h3>Methods</h3><div>Data from patients who received iTBS therapy for depression at four private clinics between January 2021 and April 2024 were extracted. Patients were assessed using the 17-item Hamilton Depression Rating Scale at baseline and after treatment completion. Correlation and multiple regression analyses were performed to investigate clinico-demographic factors and stimulation parameters associated with iTBS effectiveness. Safety was assessed using all relevant data, and effectiveness was evaluated using eligible samples.</div></div><div><h3>Results</h3><div>Among 538 patients meeting eligibility criteria for effectiveness evaluation (mean age 40.8 ± 13.8 years, 44.1 % women), 63 completed iTBS with 600 pulses, and 475 completed iTBS with 1200 pulses. Overall response and remission rates were 69.1 % and 53.7 %, respectively, with no significant difference in effectiveness between iTBS-600 and iTBS-1200. Multiple regression analysis indicated fewer depressive episodes (β = −0.103, <em>t</em> = −2.080, <em>p</em> = 0.038) and more treatment sessions (β = 0.134, <em>t</em> = 3.155, <em>p</em> = 0.002) may have contributed to the positive effect of iTBS therapy. The most common adverse event was stimulation site pain. No severe adverse events, such as seizure induction or manic switch, were observed.</div></div><div><h3>Conclusion</h3><div>The results suggest the highly favorable effectiveness of iTBS therapy for major depressive disorder in real-world settings.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 316-323"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Please, just talk to me: Self-disclosure mediates the effect of autobiographical memory specificity on adolescent self-harm and depressive symptoms in a UK population-based study","authors":"Uyen Doan,&nbsp;Dou Hong,&nbsp;Caitlin Hitchcock","doi":"10.1016/j.jad.2025.01.141","DOIUrl":"10.1016/j.jad.2025.01.141","url":null,"abstract":"<div><h3>Background</h3><div>Depression and self-harm are two of the most prevalent mental health challenges experienced by adolescents. Sharing their experiences with a parental figure (herein, self-disclosure) can be an important step in getting help, and ultimately, reducing symptoms. Understanding factors that predict self-disclosure can inform public health approaches to support adolescent mental health. We evaluated whether an adolescent's ability to retrieve specific memories of both positive and negative events may be one factor which increases self-disclosure, theorising that having more specific memories would make it easier to describe and share experiences.</div></div><div><h3>Methods</h3><div>This pre-registered (<span><span>https://osf.io/5xdns</span><svg><path></path></svg></span>) analysis evaluated data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK population-based study. We hypothesised that self-disclosure would mediate the relationship between memory specificity, and depressive symptoms, self-harm, and suicide planning. Longitudinal structural equation models evaluated mediation pathways, using three waves of data collected when adolescents (<em>N</em> = 5785) were 13-, 14- and 16-years old. Potential confounds including baseline and cross-sectional depression were considered. Multiple imputation accounted for missing data.</div></div><div><h3>Findings</h3><div>Significant indirect relationships were observed for our co-primary outcomes of depressive symptoms (b = −0∙13, SE = 0∙005) and self-harm (b = −0∙02, SE = 0∙01). Higher memory specificity at age 13 predicted higher self-disclosure at age 14 (b = 0∙27, SE = 0∙07), which predicted lower depressive symptoms (b = −0∙10, SE = 0∙02) and lower odds of self-harm at age 16 (odds ratio = 0∙87 [95 % CI [0∙78–0∙97]). Models predicting suicide planning were non-significant.</div></div><div><h3>Interpretation</h3><div>Findings suggest that specific memory retrieval in early adolescence may help to promote self-disclosure to parental figures, and indirectly, reduce poor mental health in later adolescence.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 10-17"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between mental health and cervical, thoracic, and lumbar back pain in adolescents: A cross-sectional study","authors":"Camilla Porto Campello ,&nbsp;Murilo Gominho ,&nbsp;Gustavo Aires de Arruda ,&nbsp;Jorge Bezerra ,&nbsp;João Francisco Lins Brayner Rangel ,&nbsp;Mauro Virgilio Gomes de Barros ,&nbsp;Marcos André Moura dos Santos","doi":"10.1016/j.jad.2025.01.125","DOIUrl":"10.1016/j.jad.2025.01.125","url":null,"abstract":"<div><h3>Background</h3><div>Low back pain is a significant emergent health disorder in adolescence. It is predicted that around 843 million subjects worldwide will present this condition in 2050. We investigated whether symptoms of anxiety, depression, and suicidal behavior are associated with back pain in adolescents.</div></div><div><h3>Methods</h3><div>This is a cross-sectional school-based study including 4514 student participants aged 14–19 years. Data were collected using the WHO's “Global School-Based Student Health Survey”. Anxiety symptoms were assessed with the Social Anxiety Scale for Adolescents. The Depression Scale of the Center for Epidemiologic Studies was used to estimate depressive symptomatology. Suicidal behaviors were assessed with two questions about thoughts and plans for suicide. The presence (yes, no) of each of cervical, thoracic, and lumbar back pain were assessed with the use of a drawing of the human body with spine areas delimited. Multivariable logistic regression analyses were used to study the presence of three outcomes of back pain (cervical, thoracic, and lumbar) and associated factors.</div></div><div><h3>Results</h3><div>Adolescents with cervical pain were more likely to report social anxiety (OR = 1.0, CI: 1.00–1.02). Depression symptomatology was associated with pain in the tree segments of the spine: cervical (OR = 1.01, CI: 1.00–1.02), thoracic (OR = 1.02, CI: 1.01–1.02), and lumbar (OR = 1.02, CI: 1.01–1.02). No association was observed between suicidal behavior and cervical (OR = 0.86 CI: 0.743–1.017), thoracic (OR = 0.92, CI: 0.79–1.08), and lumbar back pain (OR = 0.86, CI: 0.73–1.01).</div></div><div><h3>Limitations</h3><div>It is not possible to affirm causality in the interpretation of findings.</div></div><div><h3>Conclusions</h3><div>Social anxiety and depression symptomatology were associated with back pain in adolescents.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 366-372"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional mediation of psychological distress and food addiction influenced by childhood trauma among adolescents","authors":"Xiaofang Lin ,&nbsp;Xin Wang ,&nbsp;Chang Wang ,&nbsp;Jieshu Wu ,&nbsp;Wenyi Yang ,&nbsp;Jun Wang ,&nbsp;Yaming Yang ,&nbsp;Renzhong Zhang ,&nbsp;Jinmei Hu ,&nbsp;Fei Wang ,&nbsp;Jie Yang ,&nbsp;Yuan Lin","doi":"10.1016/j.jad.2025.01.123","DOIUrl":"10.1016/j.jad.2025.01.123","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to explore the relationship between childhood trauma, psychological distress, and food addiction in adolescents.</div></div><div><h3>Methods</h3><div>The sample comprised 4560 adolescents (46.67 % females) aged 12–19 years (15.21 ± 1.75) who participated in the School-based Evaluation Advancing Response for Child Health (SEARCH) survey, a mixed longitudinal cohort study in Jiangsu, China. Bidirectional mediation was used to assess the interplay among childhood trauma, psychological distress, and food addiction derived from a self-report survey.</div></div><div><h3>Results</h3><div>Among participants, 29.67 % reported experiencing at least one type of trauma during childhood, and 2.80 % exhibited significant symptoms of food addiction. The prevalence of depression, anxiety, and stress among participants were 32.85 %, 47.52 %, and 24.80 %, respectively. Emotional neglect (OR = 2.12[1.44–3.14]), emotional abuse (OR = 5.77 [3.96–8.41]), physical neglect (OR = 1.73 [1.17–2.56]), and physical abuse (OR = 3.53 [2.26–5.52]) had a direct positive predictive effect on food addiction. Trend analyses showed that more types of childhood traumas, and higher levels of depression, anxiety, and stress were significantly associated with higher food addiction incidence. Bidirectional mediation analysis identified that both psychological distress and food addiction mediated their respective relationships with childhood trauma. The mediating effect of psychological distress was larger than that of food addiction.</div></div><div><h3>Limitations</h3><div>The study was limited by the use of self-reported cross-sectional data.</div></div><div><h3>Conclusion</h3><div>This study indicated a bidirectional mediation between psychological distress and food addiction in adolescents, within the context of childhood trauma. The effect size of the forward mediator was larger than the reverse mediator, which may guide future treatments.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 448-455"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotion regulation repertoires predict the risk of major depressive disorder.","authors":"Xi Song, Xiang-Yang Zhang, Feng Du","doi":"10.1016/j.jad.2025.01.126","DOIUrl":"https://doi.org/10.1016/j.jad.2025.01.126","url":null,"abstract":"<p><strong>Background: </strong>Few studies explored emotion regulation (ER) repertoires (the tendency to utilize multiple ER strategies in different contexts) in patients with Major Depressive Disorder (MDD). It remains unclear to what extent emotion regulation (ER) repertoires can assess the risk of MDD and other psychiatric disorders.</p><p><strong>Method: </strong>Three subsamples including 1397 non-clinical individuals, 135 MDD patients, and 127 healthy controls (HCs) were combined to explore ER repertoires. We further built classifiers of ER repertoires to distinguish MDD patients from HCs, and additionally examined its performance based on published studies (total N = 4918).</p><p><strong>Results: </strong>Adaptive, average, maladaptive, and intensely maladaptive repertoires were identified. The classifier based on ER repertoires can effectively distinguish MDD patients from HCs, demonstrating an AUC of 0.803 (SD = 0.067). Additionally, the classifier exhibited discriminatory power for various psychopathologies in published studies, including depression, anxiety, eating disorders, PTSD, and personality disorders (AUC: 0.616-0.779).</p><p><strong>Limitations: </strong>Future studies should investigate the longitudinal influence of ER repertoires on the development of psychopathologies.</p><p><strong>Conclusions: </strong>Our findings suggest that an individual's ER repertoire is a critical psychopathological risk that can serve as a valuable indicator for assessing risk and imply the potential utility of reforming ER repertoire.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}