Journal of affective disorders最新文献

{"title":"The complex impacts of early sexual intercourse, biological sex, and sexual orientation on the risk of depression","authors":"Peilin Zou ,&nbsp;Jiajun Li ,&nbsp;Liangkai Chen ,&nbsp;Man Liu ,&nbsp;Yucong Zhang","doi":"10.1016/j.jad.2025.119938","DOIUrl":"10.1016/j.jad.2025.119938","url":null,"abstract":"<div><h3>Objective</h3><div>To better understand the impacts of biological sex, sexual orientation and early sexual intercourse on depression.</div></div><div><h3>Methods</h3><div>Data from the National Health and Nutrition Examination Survey database from 2005 to 2016 were used. First sexual intercourse before 18 years of age was defined as early sexual intercourse. Participants who were not heterosexual were considered sexual minorities.</div></div><div><h3>Results</h3><div>This study enrolled 15,231 participants. After adjusting for confounders, early sexual intercourse was a risk factor for depression only for female heterosexual (OR = 1.66, 95 % CI: 1.28, 2.16). Female biological sex was a risk factor for depression in heterosexual individuals, regardless of early sexual intercourse (without early sexual intercourse: OR = 2.77, 95 % CI: 1.30, 5.92; with early sexual intercourse: OR = 1.64, 95 % CI: 1.08, 2.50). However, female biological sex was not significantly associated with the risk of depression in sexual minorities. Sexual minority status was a risk factor for depression, except for male individuals without early sexual intercourse. Interestingly, for biological female individuals with early sexual intercourse, homosexuality was associated with a lower risk of depression (OR = 0.28, 95 % CI: 0.09, 0.85).</div></div><div><h3>Conclusion</h3><div>The impacts of early sexual intercourse, biological sex and sexual orientation on the risk of depression are contingent on each other.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119938"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial respiration in patients with bipolar disorder: Can mitochondrial respiratory control ratios serve as state and/or trait markers?","authors":"Jana Hroudová ,&nbsp;Lucie Kališová ,&nbsp;Eva Kitzlerová ,&nbsp;Martina Zvěřová ,&nbsp;Alena Lambertová ,&nbsp;Zdeněk Fišar","doi":"10.1016/j.jad.2025.119948","DOIUrl":"10.1016/j.jad.2025.119948","url":null,"abstract":"<div><h3>Background</h3><div>Bipolar disorder (BD) is a multifactorial disorder whose pathophysiology is not fully understood. Mitochondrial dysfunction has been proposed as a part of the molecular background of BD. Mitochondrial dysfunction, manifested as changes in oxygen consumption, can be detected in peripheral blood and may serve as potential state or trait marker of BD.</div></div><div><h3>Methods</h3><div>Mitochondrial respiration was analyzed in blood platelets obtained from BD patients in manic/depressive episode and in remission and compared with controls. 52 BD patients and 66 healthy age-matched controls were recruited. BD was clinically assessed using diagnostic scales and questionnaires. High-resolution respirometry was used to determine mitochondrial respiratory control ratios in both intact and permeabilized platelets.</div></div><div><h3>Results</h3><div>In BD patients in remission, the capacity of complex II-linked respiration and reserve respiration were decreased compared to controls in intact platelets. In permeabilized platelets, physiological respiration, electron transfer system (ETS) capacity, and excess capacity were decreased in BD patients compared to controls. When comparing acute states and remissions, more pronounced changes in respiratory parameters were observed in intact platelets after treatment of depression than after treatment of mania. In permeabilized platelets, qualitative changes in respiratory parameters did not depend on the type of episode prior to pharmacotherapy.</div></div><div><h3>Conclusions</h3><div>Mitochondrial dysfunction is implicated in BD pathophysiology and is associated with alterations in both activity of respiratory complexes and availability of substrates for oxidative phosphorylation. In intact platelets, complex II-linked respiration/ETS capacity could be potential blood-based trait biomarker for BD. Complex I-linked respiration/ETS capacity in permeabilized platelets could serve as state marker.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119948"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cardiometabolic index and depressive symptoms with cardiovascular and cerebrovascular diseases in middle-aged and older adults: A national prospective cohort study","authors":"Xiaopeng Cui ,&nbsp;Yunsheng Zhang ,&nbsp;Yujing Jin ,&nbsp;Zhuolin Wu ,&nbsp;Ying Gao ,&nbsp;Haiyan Su ,&nbsp;Qing Zhang ,&nbsp;Liang Wang ,&nbsp;Xinyu Yang","doi":"10.1016/j.jad.2025.119940","DOIUrl":"10.1016/j.jad.2025.119940","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular diseases (CVDs) are the leading cause of mortality globally, with ischemic heart disease and stroke being the primary contributors. Despite the widespread use of traditional risk assessment models, new biomarkers are needed to enhance predictive accuracy. Depression and cardiometabolic index (CMI) are strongly associated with CVD risk, but their combined effect remains understudied. This study aimed to examine the association between depression and CMI, individually or in combination, and the incidence of CVD in middle-aged and older adults.</div></div><div><h3>Methods</h3><div>Using data from the China Health and Retirement Longitudinal Study (CHARLS), 5808 adults aged 45 years and older were included in this analysis. Cox proportional hazard models assessed both the individual and combined effects of depression and CMI on CVD risk. Causal mediation analysis further explored the potential mediating effects of depression and CMI on CVD.</div></div><div><h3>Results</h3><div>During 9 years of follow-up, CVD occurred in 1140 participants, including 843 cases of coronary heart disease and 408 strokes. Following the adjustment for sociodemographic factors and health-related variables, a higher CMI was found to be significantly associated with an increased risk of stroke (HR: 2.015, 95 % CI: 1.458–2.786) and CVD (HR: 1.284, 95 % CI: 1.072–1.537). Additionally, depressive symptoms were significantly linked to an elevated risk of CVD (HR: 1.472, 95 % CI: 1.296–1.671). The highest incidence of CVD was found in those with a combination of depression and high CMI (HR: 1.647, 95 % CI: 1.319–2.056). Subgroup analyses revealed significant heterogeneity in the association of age, gender, education level, and chronic disease status in the risk of CVD. Mediation analyses showed a small indirect effect of CMI on CVD through depressive symptoms (ACME: -0.00186, 95 % CI: −0.00410-0.00), whereas the indirect effect of depressive symptoms on CVD through CMI was significant (ACME: -0.00108, 95 % CI: −0.00243 -0.00).</div></div><div><h3>Conclusions</h3><div>Both depression and CMI demonstrated significant associations with the risk of CVD. Furthermore, the likelihood of CVD occurrence was notably higher when both factors coexisted. The mediation analysis suggests that depression modulates CVD risk through metabolic abnormalities, providing an important basis for further pathological mechanism studies and comprehensive intervention strategies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119940"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of sleep quality and duration in associations between daily minority stress and next-day suicidal ideation in LGBTQ+ youth.","authors":"Alexandros Nikolaidis-Konstas, Annabelle M Mournet, John E Pachankis, Evan M Kleiman, Kirsty A Clark","doi":"10.1016/j.jad.2025.119951","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119951","url":null,"abstract":"<p><strong>Background: </strong>LGBTQ+ youth experience greater minority stress, poorer sleep, and heightened suicidal ideation (SI) compared to non-LGBTQ+ youth. Despite the high within-person variability of these biopsychosocial factors, few studies have utilized intensive longitudinal methods to examine their daily associations.</p><p><strong>Method: </strong>This study addresses this gap by enrolling LGBTQ+ youth aged 13-24 with past-year SI and current depressive symptoms into a smartphone-based ecological momentary assessment (EMA) study, administering three surveys per day for 28 consecutive days. Data were aggregated at the day level. Fifty participants (average age = 18.52 years, 78.0 % non-Hispanic White) contributed a total of 999 survey days. Using linear mixed-effects models with varying intercepts, we tested whether sleep quality or sleep duration mediated and/or moderated the within-person associations between daily minority stress (e.g., discrimination, rejection) and next-day active SI (desire to kill oneself), passive SI (desire to not stay alive), and non-suicidal self-injury ideation intensity.</p><p><strong>Results: </strong>Mediation analyses were non-significant; however, moderation analyses indicated that better sleep quality, but not sleep duration, rendered the association between minority stress and next-day passive SI negative.</p><p><strong>Conclusions: </strong>Findings suggest that better sleep quality might mitigate the suicidogenic impact of minority stress from one day to the next. Public health and clinical interventions aimed at reducing minority stress exposure and enhancing sleep quality may hold promise in lowering suicide risk among LGBTQ+ youth.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119951"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma exposure and risk of post-traumatic stress disorder among youth and young adults during the Russia-Ukraine war","authors":"Oleksii Serdiuk ,&nbsp;Viktor Burlaka ,&nbsp;Anna Markovska ,&nbsp;Carter Smith ,&nbsp;Vitalii Panok ,&nbsp;Vladyslav Klochkov ,&nbsp;Arash Javanbakht","doi":"10.1016/j.jad.2025.119944","DOIUrl":"10.1016/j.jad.2025.119944","url":null,"abstract":"<div><h3>Background</h3><div>The Russia-Ukraine War has led to widespread trauma. This study examines how various traumatic events influence the risk of Post-Traumatic Stress Disorder (PTSD) among Ukrainian youth and young adults.</div></div><div><h3>Objective</h3><div>To investigate the prevalence of PTSD symptoms and the association between different trauma types and PTSD risk in a war-affected Ukrainian population aged 10–26 years.</div></div><div><h3>Participants and setting</h3><div>2086 youth and young adults attending schools and universities in Eastern Ukraine after the Russian invasion onset were assessed between October 2022 and February 2023. The data were collected as part of two surveys: Ukrainian Longitudinal Study (ULS) and annual cross-sectional survey Youth and Drugs (ULS+).</div></div><div><h3>Methods</h3><div>Trauma exposure was measured using the 14-item Self-Report Trauma History Form, and PTSD symptoms were evaluated with the UCLA PTSD Reaction Index for DSM-5 Brief Form. Bivariate and multivariate logistic regression models examined associations between trauma types, sociodemographics and clinical PTSD.</div></div><div><h3>Results</h3><div>23.49 % of participants met the clinical PTSD cutoff. Interpersonal traumas like forced sex (aOR = 1.66, 95 % CI:1.03–2.68), unwanted sexual touching (aOR = 1.81, 95 % CI:1.31–2.49), and physical assault at home (aOR = 1.55, 95 % CI:1.04–2.31) showed stronger associations with PTSD than non-interpersonal traumas including war. Female sex (aOR = 0.35, 95 % CI:0.25–0.49) and lower income (aOR = 0.75, 95 % CI:0.67–0.84) increased PTSD risk.</div></div><div><h3>Conclusions</h3><div>Study reports high prevalence of PTSD symptoms among youth and young adults in a war-affected region, with interpersonal trauma – particularly sexual and physical violence – posing significantly higher risk than war-related trauma. Findings highlight the need for trauma-informed interventions tailored to the Ukrainian context.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119944"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alexithymia and facial expression recognition: A systematic review and meta-analysis","authors":"Megan L. Willis ,&nbsp;Melissa J. Miller ,&nbsp;Alissa More ,&nbsp;Xochitl de la Piedad Garcia","doi":"10.1016/j.jad.2025.119953","DOIUrl":"10.1016/j.jad.2025.119953","url":null,"abstract":"<div><h3>Objectives</h3><div>The primary aim of this systematic review and meta-analysis was to estimate the strength of the relationship between alexithymia and facial expression recognition. Secondary aims were to determine if the strength of the relationship was moderated the type of stimuli (e.g., dynamic, static) used in the study, and whether studies excluded participants with mental health disorders.</div></div><div><h3>Methods</h3><div>Web of Science, PsycINFO, MEDLINE, and Scopus database searches were conducted on 21 st June 2024. Studies were included if they comprised participants aged between 16 and 65 years, included a validated measure of alexithymia, a forced choice facial expression recognition labelling task, and reported the relationship between these variables. Risk of bias was assessed using the AXIS tool.</div></div><div><h3>Results</h3><div>Twenty-four studies were included in a random effects meta-analysis revealing a significant, medium, negative relationship between alexithymia and overall facial expression recognition ability, <em>r</em> = −0.24, CI [−0.29, −0.18]. Small, negative relationships were observed for recognition of anger, disgust, fear, happiness, and sadness. The type of stimuli moderated the strength of the relationship, with significant negative relationships between alexithymia and recognition of static facial expressions observed, but no significant relationship observed for dynamic stimuli. Exclusion of participants with mental health disorders did not moderate the strength of the relationship.</div></div><div><h3>Conclusions</h3><div>Results indicate alexithymia is associated with a global deficit labelling static facial expressions, that does not appear to be attributable to comorbid mental health disorders. Further research is needed to clarify the relationship between alexithymia and recognition of dynamic facial expressions.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119953"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression: Economic evaluation of the PAX-BD randomised controlled trial","authors":"Michael Berger ,&nbsp;Timea Helter ,&nbsp;Lumbini Azim ,&nbsp;Thomas Chadwick ,&nbsp;Paul Courtney ,&nbsp;Tony Fouweather ,&nbsp;John Geddes ,&nbsp;Paul Hindmarch ,&nbsp;Richard Morriss ,&nbsp;Paul R.A. Stokes ,&nbsp;Stuart Watson ,&nbsp;Christopher Weetman ,&nbsp;Allan H. Young ,&nbsp;R. Hamish McAllister-Williams ,&nbsp;Judit Simon","doi":"10.1016/j.jad.2025.119937","DOIUrl":"10.1016/j.jad.2025.119937","url":null,"abstract":"<div><h3>Background</h3><div>People with bipolar disorders (BD) frequently experience depressive symptoms that do not respond to available treatment options. The resulting burden for people with BD and society is substantial. This study sought to explore the cost-effectiveness of pramipexole in combination with mood stabilisers for people with treatment-resistant bipolar disorder (TRBD).</div></div><div><h3>Methods</h3><div>We calculated mean incremental cost-effectiveness ratios (ICER) of pramipexole compared to placebo over 12 and 48 weeks from health and social care (NHS + PSS) and societal perspectives for 36 participants with TRBD. Quality-adjusted life years (QALY) were captured with the EQ-5D-5L as the primary outcome measure. We used capability well-being measures (ICECAP-A, OxCAP-MH) to assess the robustness of the results and multiple imputation and bootstrapping to address missing data and small sample size.</div></div><div><h3>Results</h3><div>We found that pramipexole is dominantly more effective and cost-saving from the NHS + PSS perspective with 86 % probability of being cost-effective at £30,000/QALY gained over 12 weeks and 93 % over 48 weeks. From the societal perspective, pramipexole was more effective but also more expensive with lower probability of cost-effectiveness (36 % over 12 weeks and 48 % over 48 weeks). Uncertainty around the mean ICERs was substantial due to the small sample size.</div></div><div><h3>Limitations</h3><div>The PAX-BD trial was conducted during the COVID-19 pandemic and terminated early, resulting in a limited generalizability of resource use outside the pandemic context and a small sample size.</div></div><div><h3>Conclusions</h3><div>Pramipexole is a cost-effective treatment option for TRBD from the NHS + PSS perspective, with statistically significant increases in health-related quality of life and capability well-being over extended periods.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119937"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal maternal mood instability and child externalizing problems: An ecological momentary assessment study","authors":"Sophie G. Srivastava ,&nbsp;Curt A. Sandman ,&nbsp;Elysia Poggi Davis ,&nbsp;Laura M. Glynn","doi":"10.1016/j.jad.2025.119947","DOIUrl":"10.1016/j.jad.2025.119947","url":null,"abstract":"<div><div>This study examines whether exposure to affect fluctuations during fetal development have implications for child psychopathology. To evaluate maternal mood instability, participants (<em>N</em> = 154) completed Ecological Momentary Assessment (EMA) eight times per day across three days at 15-, 25-, and 35-weeks' gestation, and then at two months postpartum. The EMA measured depressive symptoms (Center for Epidemiologic Studies Depression Scale), anxiety (Profile of Mood States), and stress (Perceived Stress Scale). Mood instability was quantified by calculating root mean square of successive differences (RMSSD), which captures both variability and temporal dependency of mood states. When the children were 3 years old, mothers reported on their child's externalizing symptoms with the Child Behavior Checklist (CBCL) and then again at 4.5 years with the Strengths and Difficulties Questionnaire (SDQ). Bivariate correlations indicated a positive association between prenatal mood instability and child externalizing problems at both ages (<em>r</em> = 0.34, <em>r</em> = 0.29, respectively; all <em>p</em> &lt; .05). Sensitivity analyses indicated that mood instability was predictive of child externalizing problems, even after consideration of potential confounding factors, including prenatal and postnatal negative mood level as well as postnatal mood instability. Examination of maternal mood instability, in addition to mood level, provides additional and unique information regarding how maternal mental health affects child psychopathology and underscores the developmental importance of patterns of parental signals even in the very earliest stages of neurodevelopment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119947"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of allostatic load and dietary inflammatory index with depressive symptoms among U.S. adults: NHANES 2007-2018.","authors":"Baohua Zheng, Shufa Du, Mengna Wei, Wenqi Xia, Yanfen Jiang, Jiameng Zhou, Jianduan Zhang","doi":"10.1016/j.jad.2025.119955","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119955","url":null,"abstract":"<p><strong>Background: </strong>Both chronic stress and pro-inflammatory diets have been independently linked to depressive symptoms (DSs). However, their joint effects are uncertain.</p><p><strong>Methods: </strong>This study included 20,446 U.S. adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Chronic stress was quantified using allostatic load score (ALS) derived from eight biomarkers. Dietary inflammatory potential was quantified using Dietary Inflammation Index (DII) calculated from two 24-h dietary recalls. DSs were assessed using the Patient Health Questionnaire-9 (PHQ-9). Weighted logistic regression, restricted cubic splines (RCS), mediation, and population attributable fraction (PAF) analyses were conducted.</p><p><strong>Results: </strong>Both ALS (adjusted odds ratio [aOR] = 1.23, 95 % confidence interval [CI]: 1.16-1.29) and DII (aOR = 1.21, 95%CI:1.15-1.26) independently and synergistically increased DSs risk, showing significant linear trends (both P-overall<0.001) with no evidence of nonlinearity. The highest-risk group (highest ALS quartile + pro-inflammatory diet) exhibited a 3.94-fold increased risk (aOR = 4.94, 95 % CI: 2.73-8.94) compared to the reference group. DII partially mediated the ALS-DSs association (mediation proportion: 4.27 %, 95 % CI: 2.96 %-6.00 %). Eliminating high ALS and pro-inflammatory diets could prevent 40.4 % (95 % CI: 31.7-49.2 %) of depression cases.</p><p><strong>Limitations: </strong>The cross-sectional design limits causal inference, and residual confounding may exist due to unmeasured factors.</p><p><strong>Conclusions: </strong>This study highlights the independent, synergistic, and mediated effects of ALS and DII on DSs. Integrated interventions addressing both stress and diet may help mitigate depression burden in U.S. adult.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119955"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping psilocybin therapy: A systematic review of therapeutic frameworks, adaptations, and standardization across contemporary clinical trials","authors":"Mary E. Kittur ,&nbsp;L. Almendra Burgos M. ,&nbsp;Brett D.M. Jones ,&nbsp;Daniel M. Blumberger ,&nbsp;Benoit H. Mulsant ,&nbsp;Joshua D. Rosenblat ,&nbsp;M. Ishrat Husain","doi":"10.1016/j.jad.2025.119952","DOIUrl":"10.1016/j.jad.2025.119952","url":null,"abstract":"<div><div>Accumulating evidence suggests that psilocybin can produce rapid and sustained clinical benefits when administered in conjunction with psychological support. Though non-pharmacological procedures are considered integral, the field lacks therapeutic guidelines and little is known about current practices. This systematic review sought to provide a comprehensive and cross-diagnostic synthesis of current psilocybin therapy (PT) protocols across contemporary mental health related trials. Primary objectives were to define and compare PT models with respect to overall therapeutic framework, evidence-based psychotherapeutic adaptations, and therapeutic standardization measures. Database search identified 22 recent trials assessing psilocybin as treatment for major and treatment-resistant depression, medical condition-related distress, substance use, obsessive-compulsive disorders, and eating disorders. Cross-diagnostic review revealed broad consistency in therapeutic structure (i.e. before, during, and after psilocybin treatment), session themes, and external context during drug administration. However, trials varied in therapeutic intensity, diagnostic adaptations, and incorporation of evidence-based psychotherapies. Less than half of reviewed trials reported standardization measures such as manualized procedures, PT-specific training, or adherence and fidelity monitoring. With non-pharmacological treatment mechanisms still unclear, results highlight potential confounds and standardization gaps that undermine the replicability and generalizability of recent psilocybin interventions. Until adjunctive support protocols are adequately operationalized, mechanistic insight and uptake into clinical practice will remain a challenge.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119952"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}