Journal of affective disorders最新文献

{"title":"The effect of social robot interventions on anxiety in children in clinical settings: a systematic review and meta-analysis","authors":"Ruo-Yan Wu ,&nbsp;Xin-Heng Li ,&nbsp;Yi-Chen Li ,&nbsp;Zhi-Hong Ren ,&nbsp;Bing-Xiang Yang ,&nbsp;Zhen-Tao Liu ,&nbsp;Bao-Liang Zhong ,&nbsp;Chen-Ling Liu","doi":"10.1016/j.jad.2025.04.102","DOIUrl":"10.1016/j.jad.2025.04.102","url":null,"abstract":"<div><h3>Aims</h3><div>Children in clinical settings are prone to anxiety due to developmental limitations, which hinders treatment progress. This systematic review and meta-analysis aimed to evaluate the efficacy of social robot interventions compared to routine care or alternative non-pharmacological strategies in reducing anxiety among children aged 4–12 years undergoing medical procedures in clinical settings, based on evidence from randomized controlled trials.</div></div><div><h3>Methods</h3><div>The review protocol was prospectively registered in PROSPERO. Five electronic databases PubMed, Web of Science, Embase, Cochrane Library and PsycINFO were searched for randomized controlled trials (RCTs) examining the effects of SRs on children's anxiety. The search ends on 1 December 2024. A total of 10 RCTs meeting the inclusion criteria were identified, involving 877 children aged 4–12 years.</div></div><div><h3>Results</h3><div>The meta-analysis reveals a significant reduction in anxiety levels among children who interacted with social robots in clinical settings. Subgroup analyses showed that 1) Both inpatient and outpatient children exhibited reduced anxiety levels. 2) School-age children experienced a decrease in anxiety following interventions with social robots. 3) The social robots were effective in alleviating children's anxiety using distraction techniques and psycho-educational interventions.</div></div><div><h3>Conclusions</h3><div>This meta-analysis is the first to summarize the effects of social robots on anxiety in children and finds an overall positive trend. It's more effective than traditional psychotherapy and has no adverse effects due to drug use. In the context of care shortages, social robots represent a significant tool for reducing anxiety among children in clinical settings and demonstrate promising potential.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 304-315"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Ketamine and Esketamine on Measures of Quality of Life in Major Depressive Disorder and Treatment-Resistant Depression: A Systematic Review","authors":"Morgan C.H. Cheng ,&nbsp;Christine E. Dri ,&nbsp;Hana Ballum ,&nbsp;Kyle Valentino ,&nbsp;William Cheung ,&nbsp;Kayla M. Teopiz ,&nbsp;Sabrina Wong ,&nbsp;Roger S. McIntyre","doi":"10.1016/j.jad.2025.04.119","DOIUrl":"10.1016/j.jad.2025.04.119","url":null,"abstract":"<div><h3>Introduction</h3><div>The rapid and clinically meaningful antidepressant effects of ketamine and esketamine are well-established in major depressive disorder (MDD) and treatment-resistant depression (TRD) as evidenced by improvement in clinician- and patient-reported depression measures. However, there remains a need to determine how these agents affect patient-reported quality of life (QoL). Herein, we aimed to systematically review extant studies evaluating the effect of ketamine and esketamine on QoL measures.</div></div><div><h3>Methods</h3><div>A literature search was conducted on online databases (PubMed, Scopus, Web of Science, Medline, and clinicaltrials.gov) for articles from inception to September 30th, 2024, reporting on the association between ketamine/esketamine and measures of QoL in persons diagnosed with MDD or TRD. A risk of bias assessment was conducted using the ROBINS-1 tool and the Newcastle-Ottawa Scale.</div></div><div><h3>Results</h3><div>Five studies were identified that investigated the association between ketamine/esketamine and measures of QoL in persons with MDD or TRD. Scales used to measure QoL included the WHOQOL-BREF scale, Assessment of Quality of Life 8D test, and the EuroQol-5 Dimension-5 Layers. Statistically significant findings (<em>p</em> &lt; 0.001) suggest that ketamine and esketamine improve measures of QoL in persons with MDD or TRD. However, an overall moderate risk of bias was observed in the papers included in this analysis.</div></div><div><h3>Discussion</h3><div>Extant studies suggest that ketamine and esketamine treatment are associated with improvement in QoL measures in adults with MDD or TRD. Limitations of this study include hetergeneity in the types of QoL scales as well as study study duration among the studies included. Near-term research priorities should endeavour to investigate the effect of ketamine and esketamine on specific domains of QoL, respectively.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 438-442"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short sleep duration and daytime outdoor activities effects on adolescents mental health: A stress susceptibility-recovery model analysis","authors":"Xiaoyun Yang ,&nbsp;Yunjuan Yang ,&nbsp;Jie Yang ,&nbsp;Junyu Ni ,&nbsp;Huiyu Li ,&nbsp;Xiaodong Mu ,&nbsp;Chunlan Wang","doi":"10.1016/j.jad.2025.04.085","DOIUrl":"10.1016/j.jad.2025.04.085","url":null,"abstract":"<div><h3>Background</h3><div>Mental health disorders are a growing public health challenge globally. This study aimed to utilize the Stress Susceptibility-Recovery Model to identify the relationship between sleep duration, daytime outdoor activities, and major mental health outcomes among adolescents.</div></div><div><h3>Methods</h3><div>Data from the Yunnan Students' Common Disease Survey was analyzed. Multi-factorial logistic regression assessed the impact of each variable on mental health, while subgroup analyses and interaction tests examined the stability of the association between sleep duration, daytime outdoor activity, and mental health. Mendelian Randomization analysis assessed causal effects.</div></div><div><h3>Results</h3><div>The analysis included 204,158 participants aged 12–18 from 953 surveillance schools. After adjusting for covariates, the prevalence of depressive mood increased from 18.81 % (12–13 years) to 24.89 % (16–18 years); Females had a higher prevalence than males (1:1.36). Senior high school students (26.04 %) had a significantly higher rate than junior high school (21.41 %), and vocational high school students (18.42 %). Students with &lt;2 h of daytime outdoor activity had a higher prevalence of depressive mood (24.40 %) compared to those with 2 or more hours of daytime outdoor activity (19.96 % for 2 h and 19.70 % for 3 or more hours). Short sleep duration mediated the association between reduced daytime outdoor activity and increased depressive mood or affective disorders risk, supporting the Stress Susceptibility-recovery Model.</div></div><div><h3>Conclusions</h3><div>Sleep duration and daytime outdoor activity were key determinants of emotional well-being, considering aging and gender disparities.</div></div><div><h3>Limitations</h3><div>Potential sampling bias due to differences in baseline characteristics between participants with and without missing data.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 428-437"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and clinical characteristics in psychiatric outpatients with suicidality in the context of irritability","authors":"Haein Kim ,&nbsp;Yunsu Kim ,&nbsp;Jihye Ahn ,&nbsp;Hyewon Yeo ,&nbsp;Wonhye Lee ,&nbsp;Sujung Yoon ,&nbsp;In Kyoon Lyoo ,&nbsp;Seog Ju Kim","doi":"10.1016/j.jad.2025.04.121","DOIUrl":"10.1016/j.jad.2025.04.121","url":null,"abstract":"<div><h3>Background</h3><div>This study examines differences in psychiatric diagnoses and clinical symptoms between patients with suicidality with and without irritability, while also exploring the moderating role of sex on these distinctions.</div></div><div><h3>Methods</h3><div>Medical records of 6118 psychiatric outpatients in South Korea, including structured clinical interviews and standardized rating scales, were retrospectively reviewed. Patients were categorized into four groups based on the presence or absence of suicidality and irritability: suicidality with irritability (SI group; <em>n</em> = 345), suicidality only (S group; <em>n</em> = 1918), irritability only (I group; <em>n</em> = 283), and neither (N group; <em>n</em> = 3572).</div></div><div><h3>Results</h3><div>Bipolar, substance use, eating, and personality disorders were most prevalent in SI group, whereas depressive disorders were most frequent in S group. Psychotic and neurocognitive disorders predominated in I group, while anxiety, somatic symptom, sleep, and trauma- or stressor-related disorders were most common in N group. SI and S groups exhibited higher depression, anxiety, hopelessness, attention deficits, and alcohol use compared to I and N groups. S group demonstrated greater hopelessness than SI group. SI group showed lower prevalence of depressive disorders and higher bipolarity than S group, with these differences more pronounced in males than females. Somatic symptom disorders in SI group were more frequent in males but less common in females compared to S group.</div></div><div><h3>Conclusion</h3><div>This study highlights diagnostic and symptomatic distinctions among psychiatric outpatients with suicidality, depending on the presence of irritability, and underscores the moderating role of sex. The combination of suicidality and irritability appears to represent a qualitatively distinct clinical manifestation compared to suicidality alone.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 373-381"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral blood miR-16-5p as a potential biomarker for distinguishing unmedicated bipolar disorder type II from major depressive disorder","authors":"Longyan Ni ,&nbsp;Yuanyuan Zhu ,&nbsp;Lanlan Lv ,&nbsp;Rongrong Zhang ,&nbsp;Shiping Xie ,&nbsp;Xiangrong Zhang","doi":"10.1016/j.jad.2025.04.126","DOIUrl":"10.1016/j.jad.2025.04.126","url":null,"abstract":"<div><h3>Objective</h3><div>major depressive disorder (MDD) and bipolar disorder type II (BD-II) are difficult to distinguish clinically due to similar depressive symptoms and unrecognizable hypomania symptoms in the early stages. The study aims to identify these two disorders in the early stages through differential expression of microRNAs.</div></div><div><h3>Methods</h3><div>93 subjects including 66 unmedicated patients (33 MDD, 33 BD-II), and 27 healthy controls (HC) were enrolled. At the time of enrollment, all subjects' demographic data, HAMD, HCL-32, and YMRS scales were assessed. 5 ml of peripheral blood for all subjects was collected for microRNA second-generation sequencing. MicroRNA differential expression, target gene GO and KEGG analyses were performed.</div></div><div><h3>Results</h3><div>No statistical differences in demographic data were found except for age (BD-II &lt; MDD, <em>P</em> = 0.002). In terms of clinical data, there are differences in the course of the disease (BD-II &gt; MDD, <em>P</em> = 0.037) and the HCL-32 (BD-II &gt; MDD, <em>P</em> &lt; 0.01). A variance analysis of microRNA expressions across all three groups identified eight highly expressed differential miRNAs (<em>P</em> &lt; 0.001), Pairwise comparisons revealed that the expression level of miR-16-5p was lower in both MDD group (<em>P</em> &lt; 0.05) and BD-II group (<em>P</em> &lt; 0.001) than in HC group, and it was even lower in BD-II group compared to MDD group (<em>P</em> &lt; 0.01). The area under the curve (AUC) for miR-16-5p in differentiating BD-II from MDD groups was 0.723 (<em>P</em> = 0.003).</div></div><div><h3>Conclusions</h3><div>Peripheral blood miR-16-5p may serve as a potential biomarker for distinguishing unmedicated BD-II from MDD patients.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 453-461"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal ideation among young US essential workers during the COVID-19 pandemic: A longitudinal study","authors":"Chana T. Fisch ,&nbsp;Yonatan Sheffer ,&nbsp;Amit Lazarov ,&nbsp;Jun Liu ,&nbsp;Roberto Lewis-Fernández ,&nbsp;Lisa B. Dixon ,&nbsp;Yuval Neria ,&nbsp;Doron Amsalem","doi":"10.1016/j.jad.2025.04.096","DOIUrl":"10.1016/j.jad.2025.04.096","url":null,"abstract":"<div><h3>Objective</h3><div>The COVID-19 pandemic exacerbated clinical distress, with essential workers among the most impacted. Rates of suicidal ideation (SI) also rose, especially among gender minorities and young adults. The present study assessed rates of SI in a large sample of US essential workers. We hypothesized relatively high rates of SI in the sample, with the highest rates noted for cisgender women and transgender individuals. We further hypothesized an inverse relationship between age and SI, such that younger adults would express higher rates of SI.</div></div><div><h3>Methods</h3><div>This longitudinal study recruited a convenience sample of 4136 essential workers for assessment of clinical symptoms, including SI, at four timepoints: baseline, 14-day follow-up, 30-day follow-up, and 90-day follow-up. Self-reported SI was assessed using the Patient Health Questionnaire-9. The study took place in August–December 2021.</div></div><div><h3>Results</h3><div>Approximately one in five (20 %–23 %) essential workers endorsed experiencing SI at least several days of the two weeks prior to assessment at all study timepoints. An inverse relationship between age and SI was revealed, with younger adults endorsing significantly higher rates of SI. Transgender participants, but not cisgender women, endorsed significantly higher rates of SI than cisgender men. No significant change in SI appeared over time.</div></div><div><h3>Conclusions</h3><div>While levels of SI appeared relatively high among this large sample of essential workers, transgender and young adult participants stood out for their significantly higher rates of SI. This highlights the need for mental healthcare and early interventions for those at the forefront of global crises, especially among members of vulnerable groups.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 366-372"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of sex and age of treatment-resistant tendency to antidepressants: A cohort study of 325,615 patients with major depressive disorder","authors":"Dian-Jeng Li ,&nbsp;Shih-Jen Tsai ,&nbsp;Tzeng-Ji Chen ,&nbsp;Yu-Chen Kao ,&nbsp;Chih-Sung Liang ,&nbsp;Mu-Hong Chen","doi":"10.1016/j.jad.2025.04.071","DOIUrl":"10.1016/j.jad.2025.04.071","url":null,"abstract":"<div><h3>Background</h3><div>Treatment resistance to antidepressants can impose a significant burden on patients with major depressive disorder (MDD). This study aimed to evaluate the effects of age, sex, and psychiatric and physical comorbidities on the tendency toward treatment resistance to antidepressants (TRT).</div></div><div><h3>Methods</h3><div>We utilized data from the Taiwan National Health Insurance Research Database. Patients diagnosed with MDD were included in the study. Physical comorbidities were assessed using the Charlson Comorbidity Index. TRT was defined as receiving antidepressant treatment at an adequate defined daily dose, followed by a subsequent switch to another antidepressant within one year after the initial diagnosis of depression. Logistic regression was used to estimate the odds ratios (ORs) of various potential factors associated with TRT.</div></div><div><h3>Results</h3><div>A total of 325,615 patients with MDD were included in the study. After adjusting for key confounders, patients aged 20 to 29 years had the highest OR (1.60; 95 % confidence interval [CI]: 1.50–1.70) for TRT compared to the oldest age group (≥80 years). The ORs gradually decreased with increasing age. Males had a significantly lower OR (0.89; 95 % CI: 0.88–0.91) for TRT than females. TRT was also associated with the presence of physical and psychiatric comorbidities, except for autism spectrum disorder (ASD).</div></div><div><h3>Limitations</h3><div>As a naturalistic observational study, our findings are subject to potential confounding factors that cannot be fully controlled for, as would be possible in a formal randomized controlled trial.</div></div><div><h3>Conclusions</h3><div>Our study highlights the impact of age and sex on TRT. Clinicians should consider these risk factors when managing patients with MDD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 248-255"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the association between childhood socioeconomic status and later-life depression among middle-aged and older adults in China: A chain mediation model of education level and present subjective social status","authors":"Jinpeng Xu ,&nbsp;Xinyan Jiang ,&nbsp;Jiale Sun ,&nbsp;Xinhui Zuo ,&nbsp;Feier Cheng ,&nbsp;Bobkov Artem ,&nbsp;Guomei Tian ,&nbsp;Zheng Kang ,&nbsp;Liuying Wang","doi":"10.1016/j.jad.2025.04.103","DOIUrl":"10.1016/j.jad.2025.04.103","url":null,"abstract":"<div><h3>Background</h3><div>The mechanisms connecting childhood socioeconomic status (SES) to later-life depression remain underexplored. This study aims to examine the mediating roles of education level and subjective social status (SSS) between childhood SES and later-life depression among middle-aged and older adults in China, with a focus on potential gender differences.</div></div><div><h3>Methods</h3><div>5485 individuals aged 45 years and older from the 2022 China Family Panel Study were selected for analysis. Depression was assessed via the short form of the Center for Epidemiological Studies Depression Scale. Childhood SES was derived through principal component analysis. The bootstrap program was used to test the chained mediation effects.</div></div><div><h3>Results</h3><div>The average depression score among the participants was 6.00 ± 4.365. Childhood SES, education level, and subjective social status were negatively associated with depression (<em>P</em> &lt; 0.05). The chain mediation effect was significant for all participants, with education level exhibiting a 2.4 times stronger mediating effect in women than in men. Additionally, a negative correlation was observed between participants' education level and their present SSS (<em>P</em> &lt; 0.05), which contributed to a positive chain-mediated effect that links childhood SES to depression (Effect = 0.011, 95%CI = 0.006 to 0.016).</div></div><div><h3>Limitations</h3><div>Retrospective self-reported data and a cross-sectional design.</div></div><div><h3>Conclusions</h3><div>Poorer childhood SES was associated with an increased risk of later-life depression in middle-aged and older adults, and this relationship can be partially explained by education level and subjective social status. Attention should be given to those with poor childhood SES to improve their subjective perception of social status along with educational attainment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 382-389"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring mental health literacy on twitter: A machine learning approach","authors":"Yin-Ju Lien ,&nbsp;Hsin-Pei Feng ,&nbsp;Yuen-Hsien Tseng ,&nbsp;Chao-Hui Chen ,&nbsp;Wei-Hung Tseng","doi":"10.1016/j.jad.2025.04.097","DOIUrl":"10.1016/j.jad.2025.04.097","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates whether reducing mental illness stigma, enhancing help-seeking efficacy, and maintaining positive mental health mediate the relationship between the recognition of mental disorders and help-seeking attitudes.</div></div><div><h3>Methods</h3><div>During annotation phase, Twitter were collected data from April to August 2022. Tweets were retrieved using keywords aligned with five mental health literacy (MHL) facets: maintaining positive mental health (M), recognizing mental disorders (R), reducing mental illness stigma (S), help-seeking attitude (HA), and help-seeking efficacy (HE). A pretrained Sentence-BERT model generated embedding vectors for classification tasks, achieving 0.85 precision and 0.88 accuracy. Tweets from November 2021 to December 2022 were organized into three time points: R at Time 1; M, S, and HE at Time 2; and HA at Time 3. In total, 4,471,951 tweets from 941 users were analyzed. Structural equation modeling was employed to examine the temporal relationships among MHL components.</div></div><div><h3>Results</h3><div>Single mediation models indicated that better recognition of mental disorders is associated with more favorable maintenance of positive mental health, greater help-seeking efficacy, and lower mental illness stigma—all of linked to more positive help-seeking attitudes. However, in the multiple mediation model, the reduction of mental illness stigma did not significantly mediate the relationship between the recognition of mental disorders and help-seeking attitudes.</div></div><div><h3>Conclusions</h3><div>This findings suggest that recognizing mental disorders influences help-seeking attitudes through mediators like help-seeking efficacy and positive mental health maintenance. These results provide valuable insights for future interventions and policies aimed at promoting help-seeking behaviors and advancing mental health literacy.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 296-303"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed onset of depressive symptoms in deployed Dutch military personnel: Identifying distinct psychological, biochemical, and genetic pre-deployment profiles","authors":"Xandra Plas ,&nbsp;Remko van Lutterveld ,&nbsp;Bastiaan Bruinsma ,&nbsp;Eric Vermetten ,&nbsp;Elbert Geuze","doi":"10.1016/j.jad.2025.04.123","DOIUrl":"10.1016/j.jad.2025.04.123","url":null,"abstract":"<div><h3>Background</h3><div>Depression is common in the military, with research highlighting variability in depressive symptom development after deployment. This report builds on previous findings to explore differences in pre-deployment psychological, biochemical, and genetic variables across distinct depressive symptom trajectories, with a particular focus on the delayed-onset-increasing trajectory.</div></div><div><h3>Methods</h3><div>A sample of 846 military personnel deployed to Afghanistan (2005–2008) was categorized into resilient (66 %, <em>n</em> = 558), intermediate-stable (20 %, <em>n</em> = 173), symptomatic-chronic (9 %, <em>n</em> = 74), and delayed-onset-increasing (5 %, <em>n</em> = 41) trajectories from pre- to 10 years post-deployment. Differences in pre-deployment characteristics (e.g., psychological, biochemical, and genetic) among the depression trajectories were examined using a non-parametric multivariate analysis.</div></div><div><h3>Results</h3><div>Individuals in the delayed-onset-increasing trajectory had higher general mental health symptom scores than those in the resilient trajectory, but lower scores on fatigue, burnout, and personality factors than the symptomatic-chronic trajectory. No differences were found between the delayed-onset-increasing and the intermediate-stable trajectory. The symptomatic-chronic and resilient trajectories showed significant different scores across most pre-deployment psychological characteristics compared to the other trajectories. For the biochemical and genetic variables no significant differences were found.</div></div><div><h3>Conclusions</h3><div>Our study found that pre-deployment characteristics do not distinguish the delayed-onset-increasing trajectory from the intermediate-stable trajectory, with differences emerging post-deployment likely due to negative life events. Individuals vulnerable in one aspect of mental health may be at risk across multiple psychological domains, highlighting the need to focus on a broader range of symptoms to support vulnerable military personnel and enhance resilience.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 210-214"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}