Journal of affective disorders最新文献

{"title":"Prevalence and predictors of rehospitalization in youth depression patients: A 10-year longitudinal study.","authors":"Lennart Seizer, Tobias Renner, Johanna Löchner","doi":"10.1016/j.jad.2025.119800","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119800","url":null,"abstract":"<p><p>Depression affects approximately one in ten children and adolescents, with severe cases often requiring full or partial hospitalization. Despite the effectiveness of these treatments, about one third of the patients are readmitted after release, highlighting the need to identify predictors of rehospitalization. This study examined demographic, clinical, biological, and treatment-related factors in 1114 depression patients aged 8 to 18 years admitted to the Child and Adolescent Psychiatry at the University Hospital of Tübingen between 2014 and 2024. Cox regression analyses revealed that symptom severity, presence of psychotic symptoms, antidepressant medication use, and crisis ward admission significantly increased the risk of rehospitalization. Notably, immune markers such as C-reactive protein and white blood cell counts were not associated with rehospitalization risk. These findings suggest that clinical severity and specific treatment factors are critical in predicting rehospitalization, underscoring the importance of comprehensive discharge planning to reduce readmission rates and improve patient outcomes.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119800"},"PeriodicalIF":4.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pathway from childhood unpredictability to somatic symptoms among college students: The mediating role of anxiety symptoms and the moderating role of coping strategies","authors":"Shiyuan Xiang ,&nbsp;Xiaojiao Ye ,&nbsp;Xuanjing Li ,&nbsp;Pujing Chen ,&nbsp;Shan Zhao","doi":"10.1016/j.jad.2025.119749","DOIUrl":"10.1016/j.jad.2025.119749","url":null,"abstract":"<div><div>Although it has been suggested that childhood adversity could have a long-lasting influence on health, such as somatic symptoms in later life, less is known about the role of childhood unpredictability, an independent and important environmental signal, and the potential mechanism underlying this association. Besides, the extent to which different coping strategies may either mitigate or amplify this negative association is not adequately investigated. To fill this research gap, the present study investigated the relationship between childhood unpredictability and somatic symptoms among college students, whilst exploring the mediating role of anxiety symptoms and the moderating role of coping strategies. Using two-wave longitudinal data over a six-month period, a total of 992 Chinese college freshmen (67.7 % female; ages 17 to 23, <em>M</em>_<em>age</em> = 18.32, <em>SD</em>_<em>age</em> = 0.62) completed self-reported questionnaires measuring childhood unpredictability, coping strategies, anxiety symptoms, and somatic symptoms. Results showed that childhood unpredictability significantly predicted subsequent somatic symptoms among college students through increased anxiety symptoms. Moreover, both approach and avoidant coping significantly moderated the indirect association between childhood unpredictability and somatic symptoms. Specifically, employing approach coping was beneficial in reducing anxiety symptoms only among participants who experienced low childhood unpredictability. Conversely, adopting low levels of avoidant coping was particularly effective in reducing anxiety symptoms among participants who experienced high childhood unpredictability. These effects, in turn, further influenced somatic symptoms. Recommended intervention and prevention strategies include raising parental awareness of childhood unpredictability, reducing anxiety symptoms, and promoting specific coping strategies for particular stressors to alleviate somatic symptoms among college students.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119749"},"PeriodicalIF":4.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of depression and anxiety among reproductive-aged women in Bangladesh: Insights from national survey","authors":"Ehsan Ahmed ,&nbsp;Md Injamul Haq Methun ,&nbsp;Masudur Rahman Siam","doi":"10.1016/j.jad.2025.119771","DOIUrl":"10.1016/j.jad.2025.119771","url":null,"abstract":"<div><h3>Background</h3><div>Depression and anxiety are highly prevalent yet underexplored mental health issues among reproductive-aged women in Bangladesh. This study aims to investigate the determinants of depression and anxiety symptoms among reproductive-aged women in Bangladesh using data from a national survey.</div></div><div><h3>Methods</h3><div>Data from 20,029 ever-married reproductive-aged women were utilized for analysis to investigate the association between various socioeconomic and demographic, reproductive, and community-level factors. The chi-square test was used to determine the association between the outcome and various explanatory variables. The variables with P-value &lt; 0.25 in the chi-square test were only included in the Binary logistic regression model.</div></div><div><h3>Results</h3><div>Our findings reveal that depressive symptoms were reported by 4.9 % of women, while 19.5 % experienced anxiety symptoms. The main factors associated with depressive symptoms were lower educational attainment, pressure to become pregnant, and a partner occupation. These factors are also significantly associated with anxiety symptoms along with age at first birth, pregnancy termination history, and unwanted pregnancy.</div></div><div><h3>Conclusion</h3><div>The study provides an update on the determinants of depressive and anxiety symptoms, two giant components of mental health problems. This could help the policymaker to take steps to improve the overall well-being of reproductive-aged women in Bangladesh.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119771"},"PeriodicalIF":4.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipolar disorder: Systematic review of approved psychiatric medications (2008-2024) and pipeline Phase-3 medications.","authors":"Salma Ramadan, Laurel Tay, Harlene Kaur, Thomas Parrish, Salma Abdelmoteleb, Jayant Totlani, Emile Tadros, Drew Hirsch, Nathalie Murphy, Ashley Meyer, Macie Miller, Mia Pasini, Aasim Naqvi, Angela Liu, Sabrina Renteria, Rebecca Hedrick, Itai Danovitch, Robert Pechnick, Waguih William IsHak","doi":"10.1016/j.jad.2025.119778","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119778","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review evaluates psychiatric medications for bipolar disorder (BP) approved by the U.S. FDA between 2008 and 2024, alongside investigational agents in advanced clinical development, in addition to medications with exploratory evidence. It categorizes these treatments by clinical relevance, mechanism of action, efficacy, dosing, adverse effects, and guideline and real-world use.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed, FDALabel, and ClinicalTrials.gov databases for studies published between 2008 and 2024, using keywords including \"bipolar\" AND \"psychopharm*\" OR \"medic*\" OR \"pharm*.\" Two reviewers independently assessed the resulting publications, resolving any discrepancies through consensus to finalize the studies for inclusion in this review. Key findings from the selected full-text articles were extracted to compile data for the review tables. We also utilized practice guidelines for BP from the US, Canada, the UK, and Australia/New Zealand.</p><p><strong>Results: </strong>BP medications were categorized into three tiers: (1) FDA-approved and guideline-endorsed, (2) FDA-approved, with emerging clinical use, and (3) Phase 3 agents. We described eight Tier 1 and eight Tier 2 medications that received FDA approval from 2008 to 2024, seven that are actively in pipeline Phase 3 clinical trials, and six more medications with exploratory evidence.</p><p><strong>Conclusion: </strong>Advances in pharmacologic treatment for bipolar disorder over the past 16 years reflect a shift towards individualized, mechanism-based care. Our tiered framework offers clinicians and researchers a structured approach to evaluate treatment maturity and real-world applicability. Continued research and careful interpretation of the evolving pipeline and medications with exploratory evidence are essential to optimize long-term management.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119778"},"PeriodicalIF":4.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood adversities and depression according to sexual orientation and gender identity among university students in Chile","authors":"Marcelo A. Crockett ,&nbsp;Vania Martínez ,&nbsp;Daniel Núñez ,&nbsp;Scarlett Mac-Ginty ,&nbsp;Álvaro I. Langer ,&nbsp;Jorge Gaete ,&nbsp;Irene Léniz","doi":"10.1016/j.jad.2025.119758","DOIUrl":"10.1016/j.jad.2025.119758","url":null,"abstract":"<div><div>Childhood adversities (CA) are a recognized risk factor for depression. However, research on how these adversities differ based on sexual orientation and gender identity remains limited. This study aimed to examine differences in the type, number, and frequency of CA and analyze their association with depression according to sexual orientation and gender identity among university students in Chile. A total of 7213 first-year students (34 % lesbian, gay, bisexual, transgender, questioning and other diverse sexual orientations and gender identities [LGBTQ+], aged 18–30) from five Chilean universities completed an online survey assessing seven types of adversity experienced before age 18 and the occurrence of 12-month major depressive episode (MDE). Regression models were employed for the analyses. LGBTQ+ students reported significantly more types, a higher number, and a greater frequency of CA compared to heterosexual/cisgender students. No significant differences were found between the groups regarding the associations between the type or number of CA and the occurrence of 12-month MDE. However, a significant group difference emerged concerning the frequency of CA. A greater frequency of CA was associated with an increased likelihood of experiencing 12-month MDE across both groups. Notably, LGBTQ+ students exhibited a higher proportion of 12-month MDE, even with no reported CA; this difference diminished and disappeared as the frequency of CA increased. CA are highly prevalent among LGBTQ+ individuals and are associated with depression in both LGBTQ+ and heterosexual/cisgender university students. These findings underscore the urgent need for interventions to prevent exposure to CA and mitigate their detrimental effects.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119758"},"PeriodicalIF":4.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between wearable device-measured weekend catch-up sleep and brain health in UK Biobank participants.","authors":"Yanxu Zheng, Jing Bao, Tingpei Hu, Jin Wang, Jingyu Liu, Haozhe Chang, Ying He, Shuhang Huang, Zhaowei Zhu, Jinze Wu","doi":"10.1016/j.jad.2025.119779","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119779","url":null,"abstract":"<p><p>This study explores whether weekend catch-up sleep (WCS) influences the risk of major neurological and psychiatric disorders-including depression, anxiety, dementia, stroke, and Parkinson's disease (PD)-in a cohort of 91,665 participants from the UK Biobank, tracked over an average of 7.98 years. Accelerometer-measured sleep data were used to categorize WCS duration into four groups: no WCS (≤0 h), short (>0 to <1 h), medium (≥1 to <2 h), and long (≥2 h). Using Cox proportional hazards models that controlled for various confounding factors, along with restricted cubic spline analyses to examine potential nonlinear relationships, the results indicated that both medium (HR 0.82, 95 % CI: 0.72-0.92) and short (HR 0.85, 95 % CI 0.77-0.95) WCS were associated with reduced depression risk, with medium WCS also linked to lower anxiety risk (HR 0.88, 95 % CI: 0.78-0.99). These associations exhibited clear nonlinear patterns (p for nonlinearity < 0.001). However, no significant relationship was found between WCS and dementia, stroke, or PD risk. Overall, these findings highlight medium-duration WCS as a potentially beneficial practice for improving mental health outcomes-specifically, by reducing depression and anxiety risks. Nevertheless, the impact on other neurological conditions remains uncertain. Future research should verify these associations across diverse populations and further explore underlying biological mechanisms.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"119779"},"PeriodicalIF":4.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital technology empowers family education to improve adolescent mental health and reduce suicide tendency.","authors":"Xinqiao Liu, Ao Shen","doi":"10.1016/j.jad.2025.119780","DOIUrl":"10.1016/j.jad.2025.119780","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119780"},"PeriodicalIF":4.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MDD-LLM: Towards accuracy large language models for major depressive disorder diagnosis","authors":"Yuyang Sha ,&nbsp;Hongxin Pan ,&nbsp;Wei Xu ,&nbsp;Weiyu Meng ,&nbsp;Gang Luo ,&nbsp;Xinyu Du ,&nbsp;Xiaobing Zhai ,&nbsp;Henry H.Y. Tong ,&nbsp;Caijuan Shi ,&nbsp;Kefeng Li","doi":"10.1016/j.jad.2025.119774","DOIUrl":"10.1016/j.jad.2025.119774","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) impacts &gt;300 million individuals worldwide, highlighting a significant public health issue. However, the uneven distribution of medical resources and the complexity of diagnostic methods have resulted in inadequate attention to this disorder in numerous countries and regions.</div></div><div><h3>Methods</h3><div>This paper introduces a high-performance MDD diagnosis tool named MDD-LLM, an AI-driven framework that utilizes fine-tuned large language models (LLMs) and extensive real-world samples to tackle challenges in MDD diagnosis. Specifically, we select 274,348 individual records from the UK Biobank cohort and design three tabular data transformation methods to create a large corpus for training and evaluating the proposed method. To illustrate the advantages of MDD-LLM, we perform comprehensive experiments and provide several comparative analyses against existing model-based solutions across multiple evaluation metrics.</div></div><div><h3>Results</h3><div>Experimental results show that MDD-LLM (70B) achieves an accuracy of 0.8378 and an AUC of 0.8919 (95 % CI: 0.8799–0.9040), significantly outperforming existing machine and deep learning frameworks for MDD diagnosis. Given the limited exploration of LLMs in MDD diagnosis, we examine numerous factors that may influence the performance of our proposed method, including tabular data transformation techniques and different fine-tuning strategies. Furthermore, we also analyze the model's interpretability, requiring the MDD-LLM to explain its predictions and provide corresponding reasons.</div></div><div><h3>Conclusion</h3><div>This paper investigates the application of LLMs and large-scale training samples for diagnosing MDD. The findings indicate that LLMs-driven schemes offer significant potential for accuracy, robustness, and interpretability in MDD diagnosis compared to traditional model-based solutions.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119774"},"PeriodicalIF":4.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram for predicting depression risk in older adults with cognitive impairment","authors":"Nian Chen ,&nbsp;Huichao Xia ,&nbsp;Yuxi Pan ,&nbsp;Di Wu","doi":"10.1016/j.jad.2025.119766","DOIUrl":"10.1016/j.jad.2025.119766","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and validate a clinically practical nomogram for predicting depression risk in older adults with cognitive impairment.</div></div><div><h3>Methods</h3><div>Cross-sectional data from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS) included 3254 adults ≥65 years. Cognitive impairment was defined by Mini-Mental State Examination (MMSE) scores ≤24; depression by Center for Epidemiologic Studies Depression Scale (CES<img>D) ≥10. Participants were divided into training (<em>n</em> = 2278) and test (<em>n</em> = 976) sets. Variables included demographics, lifestyle, and medical history. LASSO regression (10-fold cross-validation) identified key predictors; multivariate logistic regression constructed the nomogram. Model performance was evaluated using area under the curve (AUC), calibration curves, and internal/external validation.</div></div><div><h3>Results</h3><div>Eight independent predictors were identified: younger age (OR = 0.981), living alone (OR = 1.584), smoking history (OR = 0.650), poor sleep quality (e.g., “very poor” OR = 50.326), infrequent outdoor activities (OR = 2.272), rare reading (OR = 5.558), limited TV/radio exposure (OR = 1.905), and cataract history (OR = 1.587). The nomogram demonstrated strong discrimination (AUC training: 0.807; test: 0.716) and good calibration (Hosmer-Lemeshow <em>P</em> = 0.491, internal validation; bootstrap MAE = 0.011 confirming stability).</div></div><div><h3>Conclusion</h3><div>This nomogram integrates modifiable lifestyle and clinical factors for depression risk stratification in cognitively impaired older adults. Its simplicity and accuracy suit resource-limited settings, enabling early intervention and personalized care. Limitations include the cross-sectional design, reliance on a single data source which may affect external validity beyond the tested sample, the assumption of linearity for some lifestyle factors, and the absence of a control group of depressed individuals without cognitive impairment for comparative analysis.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119766"},"PeriodicalIF":4.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sMRI-guided rTMS on brain function and structure in major depressive disorder","authors":"Pengfei Guo ,&nbsp;Xiaoyan Liu ,&nbsp;Yuyong Sun,&nbsp;Qianna Zhi,&nbsp;Yong Xia","doi":"10.1016/j.jad.2025.119772","DOIUrl":"10.1016/j.jad.2025.119772","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is a leading cause of disability worldwide. Repetitive transcranial magnetic stimulation (rTMS) guided by structural magnetic resonance imaging (sMRI) has emerged as a promising non-invasive treatment. However, the neural mechanisms underlying its efficacy remain unclear.</div></div><div><h3>Methods</h3><div>Thirty-three MDD patients and forty-two healthy controls underwent resting-state functional MRI and structural MRI scans. Among the MDD patients, thirty were rescanned after receiving 10 sessions of sMRI-guided rTMS over 2 weeks. Amplitude of low-frequency fluctuations (ALFF), resting-state functional connectivity (rsFC), and gray matter volume (GMV) were analyzed before and after treatment. The correlations of brain imaging changes after rTMS with clinical outcomes were calculated.</div></div><div><h3>Results</h3><div>At baseline, compared to the healthy controls, MDD patients exhibited decreased ALFF in the right angular gyrus, right superior frontal gyrus (SFG), and left precuneus, as well as increased ALFF in the left inferior parietal lobe (IPL) and right middle temporal gyrus (MTG). Following rTMS treatment, ALFF in the right angular gyrus and right SFG increased, while rsFC between the right angular gyrus and left MTG decreased. No significant changes in GMV were observed post-treatment. These neuroimaging changes were not significantly correlated with clinical efficacy.</div></div><div><h3>Conclusions</h3><div>These findings indicate that sMRI-guided rTMS may induce restoration of local functional activity in the angular gyrus and SFG, as well as normalization of aberrant functional connectivity within the default mode network (DMN) in MDD patients. However, correlation analyses indicate these changes may not necessarily represent the neuroimaging mechanisms underlying sMRI-guided rTMS treatment effects.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119772"},"PeriodicalIF":4.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}