Journal of affective disorders最新文献

{"title":"Hyperforin-induced gut microbiota metabolite carbocysteine protects against depressive-like behaviors in mice by modulating the colonic mucus barrier","authors":"Zheng Zhang ,&nbsp;Bo Xing ,&nbsp;Xuhui Liu ,&nbsp;Kaixuan Shi ,&nbsp;Qingjie Chen","doi":"10.1016/j.jad.2025.03.164","DOIUrl":"10.1016/j.jad.2025.03.164","url":null,"abstract":"<div><h3>Objective</h3><div>Depression affects millions, and current treatments have limitations, necessitating new approaches. Earlier research confirms Hyperforin's ability to reduce anhedonic behaviors in mice and modulate gut microbiota. This study aims to identify specific metabolic changes induced by Hyperforin that could illuminate its impact on gut microbiome metabolism, possibly uncovering novel metabolites for developing antidepressant therapies.</div></div><div><h3>Methods</h3><div>Following the chronic stress model, untargeted metabolomic analysis of fecal samples was conducted to identify metabolic changes induced by Hyperforin. Bioinformatics tools analyzed the origins of differentially expressed metabolites and their correlation with <em>Akkermansia muciniphila</em> and Muribaculum intestinale. The significant metabolite Carbocysteine was further investigated for its antidepressant effects using behavioral assays in a mouse model of depression. Additionally, the response of the colonic mucus barrier was evaluated using Periodic Acid-Schiff (PAS) staining, scanning electron microscopy (SEM), and enzyme-linked immunosorbent assays (ELISA).</div></div><div><h3>Results</h3><div>Hyperforin significantly altered fecal metabolite profiles in stressed mice, with a notable shift in 239 metabolites mainly associated with co-metabolism pathways and microbiota-specific processes. Among these, Carbocysteine emerged as a key metabolite linked to beneficial bacteria <em>Akkermansia muciniphila</em> and Muribaculum intestinale, with its levels significantly elevated following Hyperforin treatment. Behavioral assessments indicated that Carbocysteine supplementation ameliorated depressive-like behaviors in the chronic restraint stress mouse model. It also enhanced colonic mucus production and integrity.</div></div><div><h3>Conclusion</h3><div>Our research highlights Hyperforin's role in modulating gut microbiota metabolism and identifies Carbocysteine as a potential antidepressant. These findings advance our understanding of the gut-brain axis (GBA) in depression and pave the way for developing new therapeutics.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 620-630"},"PeriodicalIF":4.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fifty years later: How ego integrity and despair affect psychological reactions of older adult war veterans to the Israel-Hamas war","authors":"Yuval Palgi ,&nbsp;Lee Greenblatt-Kimron ,&nbsp;Amit Shrira","doi":"10.1016/j.jad.2025.03.165","DOIUrl":"10.1016/j.jad.2025.03.165","url":null,"abstract":"<div><div>This study examined the contribution of aging-related factors (i.e., integrity and despair) reported six months before the October 7 terror attack on Israel (W1) as predictors of probable PTSD and clinical level of depression a month after the onset of the Israel-Hamas War (W2) among older adult Israeli Yom Kippur War veterans. A web-based survey company collected a random sample of 297 Yom-Kippur War veterans, aged 68–88, who participated in both waves. Respondents completed measures of event centrality, ego integrity, and despair in W1. Probable PTSD symptoms due to the Yom Kippur War and depression symptoms were collected in both waves. Probable PTSD symptoms due to the Israel-Hamas War were assessed in W2. Three univariate logistic regressions showed that beyond exposure to wars, W1 event centrality, and W1 probable PTSD or clinical level of depression, a higher level of W1 despair significantly increased the risk of W2 probable PTSD due to the Yom Kippur War and the Israel-Hamas War, and W2 clinical level of depression. Our finding suggests that when examining the outcomes of traumatic events among older adult veterans, it is crucial to account for late-life developmental processes.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 16-21"},"PeriodicalIF":4.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the Edinburgh Postnatal Depression Scale (EPDS) identify antenatal depression and antenatal anxiety disorders? A validation study in Singapore","authors":"Ningxiang Zeng ,&nbsp;Pamela Hui Yee Goh ,&nbsp;Tze-Ern Chua ,&nbsp;Rehena Sultana ,&nbsp;Chin Wen Tan ,&nbsp;Ban Leong Sng ,&nbsp;Helen Chen","doi":"10.1016/j.jad.2025.03.149","DOIUrl":"10.1016/j.jad.2025.03.149","url":null,"abstract":"<div><h3>Objective</h3><div>Research on the usage of the Edinburgh Postnatal Depression Scale (EPDS) to detect common antenatal mental disorders in pregnant women attending outpatient clinics in Singapore is limited. This study aimed to investigate the psychometric properties of the EPDS in screening for antenatal depression (AND) and anxiety disorders.</div></div><div><h3>Method</h3><div>250 pregnant women from two national public obstetric clinics were included. The EPDS and EPDS-3A were validated against the Mini International Neuropsychiatric Interview (MINI) by analyzing key parameters at different cutoffs and obtaining the receiver operating characteristic analysis. Multivariable analysis was used to identify possible risk factors of AND.</div></div><div><h3>Results</h3><div>The prevalence of AND and anxiety disorders was 4.4 % and 3.3 %, respectively. The EPDS demonstrated strong psychometric performance in screening for both conditions, with an Area Under the Curve (AUC) of 0.927 for depression and 0.829 for anxiety. In contrast, the EPDS-3A was not recommended as a screening tool due to its relatively poor psychometric properties. For clinical applicability of AND screening using EPDS in a busy outpatient clinic, a cutoff &gt;11 is recommended, followed by further assessment and tiered care based on needs. Being a member of minority ethnic group was the only risk factor identified for AND in our study population.</div></div><div><h3>Conclusion</h3><div>EPDS performs well in screening for antenatal depression and anxiety disorders; however, further assessment is important.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 496-504"},"PeriodicalIF":4.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive changes in infant emotion regulation persist three months following birthing parent receipt of cognitive behavioral therapy for postpartum depression.","authors":"John E Krzeczkowski, Kian Yousefi Kousha, Calan Savoy, Louis A Schmidt, Ryan J Van Lieshout","doi":"10.1016/j.jad.2025.03.148","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.148","url":null,"abstract":"<p><strong>Background: </strong>Infants exposed to postpartum depression (PPD) exhibit more emotion regulatory (ER) difficulties than infants who are not. While treatments for PPD that include cognitive behavioral therapy (CBT) may adaptively alter infant ER immediately following treatment, it is unclear if these improvements persist.</p><p><strong>Methods: </strong>This study examined if adaptive changes in infant ER persisted three months after their birthing parent completed 9-weeks of CBT for PPD. We used data from n = 35 case infants (of birthing parents diagnosed with a postpartum major depressive disorder), and n = 33 healthy control infants (born to non-depressed birthing parents and matched to case infants on age, sex and family SES). A multimethod assessment of infant ER included resting-state frontal EEG asymmetry (FA), high-frequency heart rate variability (HF-HRV), and birthing parent- and partner-reported temperamental positive affect (PA). Infant ER was examined at three study visits (V1 occurred before CBT/at baseline for control infants, V2 took place immediately after CBT (9-weeks later), and V3 was three months after V2).</p><p><strong>Results: </strong>Three months after birthing parent CBT (V3), infants continued to exhibit greater left FA relative to pre-treatment [∆mean_{V1 to V3} = 0.19, [SE = 0.082], p = 0.02]-the pre-to-post treatment shift from right to left FA remained statistically significant at V3). HF-HRV at V3 also increased relative to pre-treatment [∆m_{V1 to V3} = 0.81, [0.19], p < 0.001], as did PA reported by birthing parents [∆m_{V1 to V3} = 0.64, [0.16], p < 0.001] and their partners [∆m_{V1 to V3} = 0.54, [0.18], p = 0.004]. No ER measures differed between case and control infants at the three-month visit.</p><p><strong>Conclusions: </strong>Treating PPD may set infants on a persistent adaptive ER trajectory.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent potential traumatic events and high PTSD-symptom levels are not associated with an increase in negative beliefs or expectations about oneself: A prospective, comparative, population-based study","authors":"Peter G. van der Velden ,&nbsp;Carlo Contino ,&nbsp;Marcel Das ,&nbsp;Evelien Brouwers ,&nbsp;Miquelle Marchand ,&nbsp;Lutz Wittmann","doi":"10.1016/j.jad.2025.03.133","DOIUrl":"10.1016/j.jad.2025.03.133","url":null,"abstract":"<div><h3>Background</h3><div>Persistent and exaggerated negative beliefs or expectations about oneself is one of the symptoms of PTSD (DSM-5), but the extent to which recent potential traumatic events (PTEs) increase these beliefs is largely unknown.</div></div><div><h3>Methods</h3><div>To examine this effect, a two-wave prospective study design (T1–T2) was applied. We extracted data from the <em>Victims in Modern Society</em> (VICTIMS)—study assessing PTEs and PTSD-symptomatology and the Core study Personality assessing self-esteem (2018–2023), that were conducted with the population-based Dutch LISS panel. General Linear Models (GLM) were performed to compare the one-year course of self-esteem (T1–T2) among adult respondents exposed to PTEs (N = 754) between T1 and T2 and a non-exposed comparison group (N = 4918). Intercorrelations of self-esteem (T1–T2) within subgroups were compared using Fisher <em>Z</em>-Transformation.</div></div><div><h3>Limitations</h3><div>We did not examine potentially delayed effects of PTEs on self-esteem after T2.</div></div><div><h3>Results</h3><div>The course of self-esteem did not differ between the comparison group and PTE groups with and without high PTSD-symptom levels (PTSS), although the last group had a lower self-esteem. Within the PTE group, those with higher levels of the PTSD-symptom ‘negative beliefs about oneself’ did not differ in the course of self-esteem, although they had a lower self-esteem. Intercorrelations of self-esteem were high and hardly differed between subgroups.</div></div><div><h3>Conclusions</h3><div>We found no evidence that PTEs and PTSS systematically increase negative beliefs about oneself. Affected adults respondents with PTSS already had lower pre-event self-esteem levels. Findings question the diagnostic utility of the DSM-5 criterion referring to negative beliefs or expectations about oneself.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 527-534"},"PeriodicalIF":4.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation mediates the association between dietary inflammation index and incident anxiety and depression in UK Biobank.","authors":"Yizhao Zhou, Chengcheng Zhang, Jingya Li, Ying Zheng, Shuiyuan Xiao","doi":"10.1016/j.jad.2025.03.101","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.101","url":null,"abstract":"<p><strong>Background: </strong>Evidence on whether systemic inflammation mediates the association between diet and depression and anxiety is lacking.</p><p><strong>Methods: </strong>We analyzed 55,799 participants from the UK Biobank, assessing dietary inflammatory index (DII) based on 3 days' 24-hour dietary recall. Systemic inflammation was represented by systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI). Incident depression and anxiety were ascertained through linkage to hospital records, and Cox proportional hazard regression models evaluated the associations, with mediation analysis performed for systemic inflammation.</p><p><strong>Results: </strong>DII ranged from -6.87 to 4.88 with a median of -0.67. After a median follow-up time of 9.12 years, 1409 were diagnosed with depression and 1806 with anxiety. Higher DII level is associated with the incident risk of depression (HR_Q4vsQ1 = 1.20, 1.09-1.32, P < 0.001) and anxiety (HR_Q4vsQ1 = 1.10, 1.00-1.21, P < 0.001). SIRI and SII respectively mediate 4.12 % (95 % CI = 1.30 %-23.3 %, P < 0.001) and 4.43 % (95 % CI = 1.89 %-43.75 %, P < 0.001) of the association between DII and depression incidence. As for anxiety, SIRI mediated 8.27 % (95 % CI = 1.44 %-15.31 %, P < 0.001) and SII mediated 4.19 % (95 % CI = 1.58 %-11.47 %, P < 0.001), respectively.</p><p><strong>Limitations: </strong>The potential coexistence of anxiety and depression with other psychiatric disorders and limitations in data on changes in DII and inflammation markers over time may bias the findings. The study's generalization is constrained by the demographic of participants.</p><p><strong>Conclusion: </strong>Our findings suggest that DII is positively associated with depression and anxiety, which may be mediated by SII/SIRI.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet quality and depression risk: A systematic review and meta-analysis of prospective studies.","authors":"Patricio Molero, Francesco De Lorenzi, Adam Gędek, Celina Strater, Elena Popescu, Felipe Ortuño, Willem Van Der Does, Miguel Angel Martínez-González, Marc L Molendijk","doi":"10.1016/j.jad.2025.03.162","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.162","url":null,"abstract":"<p><strong>Background: </strong>The association between diet and the onset and treatment of depression is unclear. This study aims to estimate the evidence for the prospective association between diet quality and depression.</p><p><strong>Methods: </strong>Systematic searches in PubMed, Web of Science and Embase up to 2024/01/04 of propective studies on the potential relationship between diet quality and depression identified 21 randomized clinical trials (RCT) and 92 prospective cohorts (PC) (>700,000 participants), that were pooled in random-effects frequentist and Bayesian meta-analyses.</p><p><strong>Results: </strong>Treatment-RCT yielded anecdotal-to-moderately strong support for the hypothesis that dietary interventions improve depression (d = -0.80, 95 % CI = -1.46 to -0.14), though their internal validity was low. Interventional effects were observed in nonpatient samples (d = -0.17, -0.29 to -0.08). Prevention-RCT yielded strong evidence indicating no association. Data from PC showed that adherence to some dietary patterns/food groups was associated with depression, e.g., adherence to the Mediterranean-diet was associated to fewer self-reported symptoms (OR = 0.91, 95%CI = 0.88-0.96), with anecdotal-to-moderate strength of evidence but no dose-response relationship. For most dietary patterns and food-groups (e.g., fish), data supported the null-hypothesis of no effect. Effect moderation was present: associations were evident when depression was self-reported but not when diagnosed. Postpartum-depression studies yielded evidence showing dose-response associations between fish (OR = 0.84, 95%CI = 0.78-0.91) and dietary DHA/EPA/Omega3 consumption (OR = 0.84, 95%CI = 0.77-0.92) with self-reported depression-scores.</p><p><strong>Conclusions: </strong>The strength of the current evidence on the hypothesis that dietary quality influences depression outcome is very low, due to reverse causation and low internal and construct validity. The clinical significance of fish/dietary DHA/EPA/Omega3 intake to reduce the risk of postpartum-depression should be further investigated.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic network alterations and associated neurotransmitter signatures across major psychiatric disorders in adolescents: Evidence from edge-centric analysis of time-varying functional brain networks","authors":"Jing Wang ,&nbsp;Jianshan Chen ,&nbsp;Junle Li ,&nbsp;Qiuxia Wu ,&nbsp;Jiaqi Sun ,&nbsp;Xiaofei Zhang ,&nbsp;Xuan Li ,&nbsp;Chanjuan Yang ,&nbsp;Liping Cao ,&nbsp;Jinhui Wang","doi":"10.1016/j.jad.2025.03.151","DOIUrl":"10.1016/j.jad.2025.03.151","url":null,"abstract":"<div><h3>Background</h3><div>Adolescence is a pivotal phase marked by heightened vulnerability to the onset of psychiatric disorders. However, there are few transdiagnostic studies of dynamic brain networks across major psychiatric disorders during this phase.</div></div><div><h3>Methods</h3><div>We collected resting-state functional MRI data from 189 adolescent patients (61 with bipolar disorder, 73 with major depressive disorder, and 55 with schizophrenia) and 181 healthy adolescents. Functional networks were constructed using a state-of-art edge-centric dynamic functional connectivity (DFC) approach.</div></div><div><h3>Results</h3><div>Four DFC states were identified for the healthy adolescents that were related to different behavioral and cognitive terms. Disorder-related alterations were observed in two states involving motor and somatosensory processing and one state involving various cognitive functions. Regardless of the state, the three patient groups exhibited lower FC that were mainly involved in edges between different functional subsystems and were predominantly linked to regions in the somatomotor network. The patients with major depressive disorder additionally showed increased FC that were primarily linked to default mode regions. Graph-based network analysis revealed different patterns of disrupted small-world organization and altered nodal degree in the disorders in a state-dependent manner. The nodal degree alterations were correlated with the concentration of various neurotransmitters. Intriguingly, the noradrenaline concentration was engaged in the nodal degree alterations in each patient group. Finally, decreased FC involving regions in the somatomotor network showed significant correlations with clinical variables in the major depressive disorder patients.</div></div><div><h3>Conclusion</h3><div>These findings may help understand the developmental pathways associated with the heightened vulnerability to major psychiatric disorders during adolescence.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 401-412"},"PeriodicalIF":4.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between loneliness and suicidality: A systematic review of general populations and persons with depression-related disorders.","authors":"Andy Lu, Allyssa Chan, Trisha Menon, Gia Han Le, Sabrina Wong, Roger Ho, Heidi Ka Ying Lo, Taeho Greg Rhee, Poh Khuen Lim, Hernan F Guillen-Burgos, Roger S McIntyre","doi":"10.1016/j.jad.2025.03.150","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.150","url":null,"abstract":"<p><strong>Background: </strong>Loneliness and suicidality are interrelated phenomena with implications for public health and clinical psychiatry. This systematic review seeks to analyze this association in general population samples of varying age groups and persons with depression-related disorders-depressive and bipolar disorders.</p><p><strong>Methods: </strong>Search terms in this review include words related to loneliness suicidality general populations age groups (elderly adults and adolescents) and depression-related disorders. Databases include PubMed OVID (MedLine Embase AMED PsychINFO JBI EBP) and Web of Science. The search occurred from database inception to May 27, 2024.</p><p><strong>Results: </strong>Fifty-six studies met eligibility criteria: 52 involving general population samples and 4 involving patients with depression-related disorders. In healthy adults (18-64yo), loneliness showed a moderate positive correlation with suicidality (r = 0.26 to 0.59), while correlations in elderly (65+) (r = 0.498) and adolescents (13-17yo) were weaker. In depression-related disorders, correlations ranged from weak to moderate (r = -0.06 to 0.40), with associations stronger in unadjusted models (UOR = 2.8 to 7.07). Depressive symptoms were a mediator.</p><p><strong>Limitations: </strong>We mostly found cross-sectional studies. Mixed age group studies made direct comparisons difficult. In addition, an inadequate amount of healthy elderly and depression-related studies were found. We also only focused on age and depressive symptoms as a covariate.</p><p><strong>Conclusion: </strong>A generally moderate positive association was observed between loneliness and suicidality, particularly in healthy adults. However, age moderates these associations, warranting further exploration. The role of depression-related disorders in these associations remains unclear, highlighting the need for longitudinal and diverse population studies to inform prevention strategies.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The abnormal choline to creatine ratio of the right anterior cingulate gyrus is linked to cognitive impairment in youth with major depressive disorder.","authors":"Shijie Luo, Shunkai Lai, Linna Chu, Ying Wang, Pan Chen, Xiaojie Ye, Jinping Zhuo, Munila Abula, Yikun Liang, Dongxue Wei, Meiqi Zhang, Jie Yin, Xiaodan Lu, Jianzhao Zhang, Yiliang Zhang, Shuming Zhong, Yanbin Jia","doi":"10.1016/j.jad.2025.03.161","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.161","url":null,"abstract":"<p><strong>Background: </strong>Previous studies indicated that the notion that 20-40 % of patients with major depressive disorder (MDD) have cognitive impairments (CI). The mechanism of cognitive deficits in MDD is largely unknown. Recent evidence suggests that metabolic changes may be associated with poorer cognitive outcomes in MDD.</p><p><strong>Method: </strong>We recruited 105 right-handed, untreated youth with MDD patients, and 68 demographically matched healthy controls (HCs), and underwent the MATRICS Consensus Cognitive Battery (MCCB) assessment and proton magnetic resonance spectroscopy (1H-MRS) scan in the anterior cingulate gyrus (ACC) and putamen. Differential and association analysis was performed to investigate the relationship between cognitive performance and neurometabolism ratios of ACC and putamen in MDD groups.</p><p><strong>Results: </strong>Thirty-nine patients defined as CI group (>1.5 SD below the normal mean of MCCB in two or more MCCB domains) and 67 patients for NCI (without CI) group. The CI group exhibited significantly higher Cho/Cr ratios in the right ACC when compared to the NCI group and HCs groups. Both CI and NCI groups showed significantly higher Cho/Cr ratios in the left putamen compared to the HCs. Meanwhile, the number of episodes were positively correlated with the Cho/Cr ratios in the left putamen (r = 0.35, p = 0.035) in CI group.</p><p><strong>Conclusion: </strong>Our findings suggest that both CI and NCI MDD may experience putamen dysfunction. Additionally, the frequency of depressive episodes appears to have a cumulative effect on alterations in the Cho/Cr ratios in the putamen. Concurrently, an increased Cho/Cr ratio in the ACC is linked to widespread cognitive deficits in MDD patients. These results may point to a subgroup of patients who could benefit from interventions aimed at modulating brain functional status.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}