Journal of affective disorders最新文献

{"title":"An exploratory analysis on the association between suicidal ideation and the microbiome in patients with or without major depressive disorder.","authors":"Vincent Chin-Hung Chen, Shu-I Wu","doi":"10.1016/j.jad.2024.10.120","DOIUrl":"https://doi.org/10.1016/j.jad.2024.10.120","url":null,"abstract":"<p><strong>Background: </strong>Scarce research has investigated associations between suicidal ideation and the gut microbiota. We aimed to explore variations in the gut microbiome associated with suicidal ideation and major depressive disorder (MDD).</p><p><strong>Method: </strong>A case-control study compared abundances of fecal microbiota and biomarkers of gut permeability among patients with MDD, with or without suicidal ideation, and healthy volunteers without depression. Information on demographic variables and assessments of suicidal ideation (Beck Suicidal Ideation Scale), depression (Hamilton Depression Scale, Patient Health Questionnaire, Hospital Anxiety and Depression Scale- Depression), as well as anxiety (Hospital Anxiety and Depression Scale- Anxiety), were obtained. Univariate and multivariate regression model was performed to explore the possible predictors of suicidal ideation.</p><p><strong>Results: </strong>Among the 140 participants, significant differences in Beta diversity were found between MDD patients with (n = 43) or without suicidal ideation (n = 34), and healthy volunteers (n = 42) (all p < 0.001). The strain of g-Phascolarctobacterium was found to have significant positive associations with scores of BSSI and BSSI Part 1 (suicidal ideation), particularly in MDD patients with suicidal ideation, after controlling for demographic and mood covariates. Mediation analyses revealed that g-Phascolarctobacterium may be a partial mediator between depression and suicidal ideation; however, it is also possible that the association between g-Phascolarctobacterium and suicidal ideation was partially mediated by the level of depression.</p><p><strong>Conclusion: </strong>We found different compositions, diversities, and possible mediating of the gut microbiome associated with suicidal ideations. Potential mechanisms need further investigation to establish whether this reflects a biological process that might be the focus for intervention development.</p><p><strong>Synopsis: </strong>Our objective was to investigate whether the diversities and abundances of the gut microbiome varied in people with or without suicidal ideation and with or without MDD after considering possible demographic and mood confounders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-year course over time and predictors of suicidal ideation in depressed older patients","authors":"","doi":"10.1016/j.jad.2024.10.097","DOIUrl":"10.1016/j.jad.2024.10.097","url":null,"abstract":"<div><h3>Background</h3><div>It is important to know predictors of long-term course over time of suicidal thoughts and ideation in depressed older persons.</div></div><div><h3>Methods</h3><div>In this study, 378 depressed older persons were interviewed at baseline, and after 2 and 6 years to evaluate the presence of depressive disorder. The Inventory of Depressive Symptomatology (IDS) was administered every 6 months for 6 years. Latent Class Growth Analysis was performed on the IDS item on suicidal ideation to identify subgroups with different trajectories.</div></div><div><h3>Results</h3><div>Five subgroups with suicidal ideation trajectories were identified: 1) severe, transient (10.9 %), 2) severe, persisting (8.0 %), 3) mild, but increasing (14.9 %), 4) moderate, persisting (35.6 %), and 5) no thoughts (30.6 %). Mixed model analysis showed that trajectories were related to 6-year course of depressive symptoms. Yet, suicidal ideation or thoughts of loss of meaning of life were still present in 22.7 % and 17.4 % of those who remitted after 2 and 6 years. Independent of baseline depressive symptom severity, loneliness, childhood trauma, history of suicidal ideation or attempt, openness to experience, earlier age of depression onset, anxiety symptom severity and worse mastery predicted worse trajectories.</div></div><div><h3>Limitations</h3><div>47 % dropped out at 6-years follow-up, we did not distinguish between thoughts of death and suicide, we did not assess death by suicide.</div></div><div><h3>Conclusions</h3><div>Although trajectories of suicidal ideation and thoughts of loss of meaning of life were strongly related to the course of depression severity, they also appear after remission. Clinicians should be vigilant for suicidal ideation or death wish, even after remission of depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omnivore, vegan and vegetarian diet quality associations with depressive symptoms: A comparative cross-sectional analysis of the Australian Longitudinal Study on Women's Health","authors":"","doi":"10.1016/j.jad.2024.10.119","DOIUrl":"10.1016/j.jad.2024.10.119","url":null,"abstract":"<div><h3>Background</h3><div>Depressive symptoms are experienced by &gt;350 million people globally. Research suggests that a diet rich in plant foods could be protective against depressive symptoms, but vegans and vegetarians who eat a predominant plant-based diet are known to have higher depressive symptoms than omnivores.</div></div><div><h3>Methods</h3><div>This study aims to explore a secondary analysis of the association between diet quality and depressive symptoms in women born between 1973 and 1978 who follow vegan, vegetarian, and omnivore diets from the Australian Longitudinal Study of Women's Health at baseline (1996) and at three time points (2000, 2003 and 2009).</div></div><div><h3>Results</h3><div>After controlling for covarying factors, there was a significant association between diet quality and depressive symptoms in both the plant-based and omnivore groups at both time points <em>F</em>(9, 4851) = 106.90, <em>p</em> &lt; .001. There was no significant difference between diet quality and depressive symptoms between diet type.</div></div><div><h3>Conclusions</h3><div>Despite diet type (plant-based or omnivore), adhering to a high-quality diet may decrease depressive symptoms and a low-quality diet may increase depressive symptoms in Australian women.</div></div><div><h3>Limitations</h3><div>Caution should be exercised when interpreting these results due to the small sample sizes and small resulting coefficients, there is uncertainty that coefficients this small can be associated with any meaningful change in an individual being treated for depressive symptoms in a clinical setting.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of vicarious trauma, depression, anxiety, stress, post-traumatic stress disorder, and resilience among the Tigrayan diaspora in Australia: A cross-sectional study following the Tigray conflict","authors":"","doi":"10.1016/j.jad.2024.10.075","DOIUrl":"10.1016/j.jad.2024.10.075","url":null,"abstract":"<div><div>Ethiopia's Tigray in 2020. This war has had a detrimental impact on the mental health and overall wellbeing of Tigrayans living in other countries and abroad. The present study investigated the state of mental health and wellbeing among Tigrayan diaspora living in Australia, many of whom are migrants, but most are refugees.</div></div><div><h3>Methods</h3><div>We employed a cross-sectional survey gathered through Qualtrics-designed hybrid data collection techniques. We assessed vicarious trauma using the secondary traumatic stress scale (STSS), depression, anxiety, and stress using the Depression Anxiety and Stress Scale-21 (DASS-21), PTSD using PTSD Checklist- Civilian Version (PCL<img>C), and resilience using the Connor–Davidson Resilience Scale (CD-RISC-10). We calculated the psychometric properties of these tools among the population. We employed binary logistic regression analysis to identify factors associated with the outcomes of interest.</div></div><div><h3>Findings</h3><div>241 people participated in the survey. Intrusion symptoms of vicarious trauma were prevalent among 85.6 % (172/201) of participants, avoidance symptoms of vicarious trauma among 87.6 % (176/201) of participants, and arousal vicarious trauma among 83.6 % (168/201) of participants. Extremely severe depression was prevalent among 38.2 % (81/212) of participants, extremely severe anxiety among 47.6 % (101/212) of participants, and extremely severe stress among (26.9 % (57/212) of participants. PTSD symptoms were prevalent among 75 % (151/204) of participants. Resilience was reduced among 67.5 % (135/200) of participants.</div></div><div><h3>Interpretation</h3><div>The study implies that conflict occurring in one's home country can have a profound impact on the mental wellbeing of individuals residing abroad.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and acceptability of brain stimulation for anxiety disorders, OCD, and PTSD: A systematic review and network meta-analysis of randomized controlled trials","authors":"","doi":"10.1016/j.jad.2024.10.071","DOIUrl":"10.1016/j.jad.2024.10.071","url":null,"abstract":"<div><h3>Background</h3><div>The present study aimed to conduct a systematic review and network meta-analysis to investigate the efficacy and acceptability of brain stimulation techniques (BSTs) for anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD).</div></div><div><h3>Methods</h3><div>A comprehensive search was performed in Embase, PubMed, Web of Science, PsycINFO, Cochrane, <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> and HowNet databases for studies published before September 10, 2023. Randomized clinical trials that involved deep brain stimulation (DBS), electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), sham therapy, or health control were included for analysis. The primary outcome was efficacy, while acceptability was considered as a secondary outcome.</div></div><div><h3>Results</h3><div>The sample consisted of 1333 patients with various anxiety disorders including social anxiety disorder, general anxiety disorder, panic disorder, social panic, obsessive-compulsive disorder, post-traumatic stress disorder, and agoraphobia, recruited from 41 trials with 86 treatment arms. Network meta-analysis showed that some BSTs had higher efficacy compared to controls, including DBS, ECT, cathodal tDCS, high-frequency rTMS (hf-rTMS), anodal tDCS, and low-frequency rTMS (lf-rTMS). Furthermore, hf-rTMS, lf-rTMS, and ECT had high acceptability in terms of odds ratio (OR).</div></div><div><h3>Limitations</h3><div>This study has limitations, including a focus on specific types of brain stimulation for anxiety disorders, OCD and PTSD and not considering factors like stimulation parameters. Future research should explore a broader range of technologies and parameters across various psychiatric and neurological conditions.</div></div><div><h3>Conclusion</h3><div>The study results suggest that BSTs are effective treatments for anxiety disorders, OCD and PTSD; lf-rTMS may be considered as the most promising option.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What empathizers do: Empathy and the selection of everyday interpersonal emotion regulation strategies","authors":"","doi":"10.1016/j.jad.2024.10.056","DOIUrl":"10.1016/j.jad.2024.10.056","url":null,"abstract":"<div><h3>Background</h3><div>Empathic behavior is crucial in promoting positive social outcomes and strengthening interpersonal bonds. Research on how empathy modulates responses to others' emotions remains scarce yet is fundamental for elucidating mechanisms of impaired social functioning in psychopathology and its treatment.</div></div><div><h3>Methods</h3><div>Two ecological momentary assessment studies (<em>N</em>s = 125 and 204) investigated participants' empathy and usage of interpersonal emotion regulation strategies in 5537 social interactions. We measured empathy, a multi-faceted construct, as dissected into its components of mentalizing and experience sharing in Study 1, while Study 2 additionally investigated empathic concern and personal distress.</div></div><div><h3>Results</h3><div>Findings revealed that empathizers engage in significantly increased other-focused regulation, especially when feeling empathic concern. We also found differences in the strengths of the links between empathy and responses to others' emotions: When we mentalize, share others' emotions, or feel concerned, we choose more relationship-oriented strategies, including validation and soothing, and less cognitive reappraisal and avoidance to regulate others' emotions. In contrast, when personally distressed by others' emotions, we select more cognitive reappraisal and avoidance and less relationship-oriented strategies.</div></div><div><h3>Limitations</h3><div>Both studies relied on regulator reports.</div></div><div><h3>Conclusions</h3><div>Empathy facets distinctly shape our responses to others' emotions and can make us increasingly emotionally responsive and relationship-oriented. Understanding these dynamics can enhance the treatment of affective disorders characterized by deficits in social functioning.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of symptom change in the mental health of refugees and asylum seekers (MEHIRA) study examining the effects of a stepped and collaborative care model – A multicentered rater-blinded randomized controlled trial","authors":"","doi":"10.1016/j.jad.2024.10.103","DOIUrl":"10.1016/j.jad.2024.10.103","url":null,"abstract":"<div><h3>Background</h3><div>Predictors of symptom improvement are an essential starting point for tailoring psychological treatments to each individual and, in turn, increasing treatment efficacy overall. However, such research regarding refugees/asylum seekers from Arabic-/Farsi-speaking countries is lacking. The current study aimed to characterize predictors for symptom improvement in the Mental Health in Refugees and Asylum Seekers (MEHIRA) study, one of the most extensive multicentered controlled trials on a nationwide stepped and collaborative care model compared to routine German mental health care.</div></div><div><h3>Methods</h3><div>Variables characterizing symptom change were chosen using backward elimination and inserted into logistic regression models for two depression endpoints, namely the Patient Health Questionnaire-9 (PHQ-9) and the Montgomery Asberg Depression Rating Scale (MADRS).</div></div><div><h3>Results</h3><div>Six variables were found to be at least marginally significantly associated with symptom decrease in both outcomes: baseline depressive symptom load, comorbid post-traumatic stress disorder, identifying as a refugee, years of schooling, physical health, and post-migration social status difference. Additionally, psychological health and resilience were marginally significant for one of the models.</div></div><div><h3>Limitations</h3><div>Some predictor constructs - such as social support - were not adequately measured to replicate previous findings. Additionally, the study was underpowered for symptom change prediction of individual treatments beyond the group intervention.</div></div><div><h3>Conclusions</h3><div>These outcomes indicate that trauma-related elements as well as content on refugee identity and post-migration social status changes should be included in depression interventions for refugees. Further, recommendations for future outcome prediction studies are made.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-criticism is a real-time predictor of non-suicidal self-injury and disordered eating: An ecological momentary assessment study among treatment-seeking individuals.","authors":"Christina L Robillard, Laurence Claes, Sarah E Victor, Inez Myin-Germeys, Glenn Kiekens","doi":"10.1016/j.jad.2024.10.121","DOIUrl":"https://doi.org/10.1016/j.jad.2024.10.121","url":null,"abstract":"<p><strong>Background: </strong>Although theory and research implicate self-criticism as a risk factor for non-suicidal self-injury (NSSI), the nature of this association in daily life remains unclear. This study used ecological momentary assessment (EMA) to address whether (1) trait and state self-criticism elevate the risk of NSSI, (2) state self-criticism predicts NSSI behavior in real-time via increased NSSI urge intensity, and (3) the risk pattern extends to disordered eating (DE; binge eating, purging, restrictive eating).</p><p><strong>Methods: </strong>A total of 125 treatment-seeking individuals who self-injure (87.20 % female; M_age = 22.98, SD = 5.32) completed measures of trait self-criticism at intake, followed by six daily assessments for 28 days (15,098 assessments; median compliance = 78.6 %) measuring self-critical thoughts, NSSI, and DE. Multilevel vector autoregressive models were constructed within a dynamic structural equation modeling framework.</p><p><strong>Results: </strong>Patients who reported higher mean state self-critical thoughts experienced more intense NSSI urges and an increased risk for NSSI behavior during treatment. Higher-than-usual self-critical thoughts predicted NSSI urge intensity and NSSI behavior within the following 2 h. NSSI urge intensity partially mediated the effect of self-critical thoughts on NSSI behavior. Trait self-criticism did not predict comorbid DE, but aggregated state self-critical thoughts were associated with binge and restrictive eating. The within-person risk pattern of self-criticism generally extended to DE, with full mediation via DE urges for purging and restrictive eating, but not binge eating.</p><p><strong>Conclusions: </strong>Self-criticism is a real-time predictor of NSSI and comorbid DE. These findings underscore the relevance of monitoring self-criticism outside the therapy room, as it may be an important treatment target.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts.","authors":"Humam Emad Rajha, Reem Abdelaal, Khouloud Charfi, Aisha O Alemadi, Alyaa S Al-Sheraim, Mubarak A Al-Maadid, Youssef Louati, Suhail Doi, Salma M Khaled","doi":"10.1016/j.jad.2024.10.114","DOIUrl":"10.1016/j.jad.2024.10.114","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis, a significant public health concern, affects millions of adult women globally, leading to increased morbidity and fracture risk. Antidepressant use, prevalent in this demographic, is suggested to influence bone mineral density (BMD), yet evidence remains limited across antidepressant classes.</p><p><strong>Objective/aim: </strong>We investigated the association between antidepressant use and osteoporosis in a representative sample of adult women in the United States, focusing on different classes of antidepressants and their potential associations with BMD and fracture risk.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using data from ten cohorts of the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2000 to 2017-2020. The sample included adult women, with data collected on antidepressant use, BMD scores, and reported fractures. Statistical models adjusted for potential confounders such as Major Depressive Disorder (MDD), age, physical activity, and comorbidities.</p><p><strong>Results: </strong>Antidepressant use was associated with a 44 % increase in the odds of osteoporosis. Phenylpiperazines showed the highest association, followed by miscellaneous antidepressants and tricyclic antidepressants (TCAs). Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) also demonstrated significant, though comparatively lower associations. The odds of fractures were elevated by 62 % among antidepressant users, particularly with phenylpiperazines and miscellaneous antidepressants. A dose-response analysis indicated that both the number and duration of antidepressants were associated with increased odds of osteoporosis.</p><p><strong>Conclusion: </strong>Our findings underscore the need for heightened awareness of the adverse effects of antidepressants on bone health, particularly in adult women. Careful consideration is necessary when prescribing these medications, especially in populations at risk for osteoporosis and MDD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal beta bursts of depression in the orbitofrontal cortex and its relationship with clinical symptoms.","authors":"Li Xue, Xiaowen Hu, Siqi Zhang, Zhongpeng Dai, Hongliang Zhou, Zhilu Chen, Zhijian Yao, Qing Lu","doi":"10.1016/j.jad.2024.10.092","DOIUrl":"https://doi.org/10.1016/j.jad.2024.10.092","url":null,"abstract":"<p><strong>Background: </strong>Recent researches have reported that frequency-specific patterns of neural activity contain not only rhythmically sustained oscillations but also transient-bursts of isolated events. The aim of this study was to investigated the correlation between beta burst and depression in order to explore depressive disease and the neurological underpinnings of disease-related symptoms.</p><p><strong>Methods: </strong>We collected resting-state MEG recordings from 30 depressive patients and a matched 40 healthy controls. A Hidden Markov Model (HMM) was applied on source-space time courses for 78 cortical regions of the AAL atlas and the temporal characteristics of beta burst from the matched HMM states were captured. Group differences were evaluated on these beta burst characteristics after permutation tests and, for the depressive group, associations between burst characteristics and clinical symptom severity were determined using Spearman correlation coefficients.</p><p><strong>Results: </strong>At a threshold of p=0.05corrected, burst characteristics revealed significant differences between depression patients and controls at the group level, including increased burst amplitude in frontal lobe, decreased burst duration in occipital regions, increased burst rate and decreased burst interval time in some brain regions. Furthermore, burst amplitude in the orbitofrontal cortex (OFC) was positively related to the severity of sleep disturbance and burst rate in the OFC was negatively related to the severity of anxiety in depression patients.</p><p><strong>Conclusions: </strong>The findings highlight OFC may be a targeted area responsible for the anxiety and sleep disturbance symptom by abnormal beta burst in depressive patients and beta burst characteristics of OFC might serve as a neuro-marker for the depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}