Journal of affective disorders最新文献

{"title":"Lactate phosphorylates nNOS^Ser1412 and protects against restraint stress-induced memory impairment in mice.","authors":"Yuki Tomiga, Masaki Kusano, Akiko Takano, Yasuki Higaki, Hirokazu Takahashi","doi":"10.1016/j.jad.2025.120039","DOIUrl":"10.1016/j.jad.2025.120039","url":null,"abstract":"<p><p>Lactate is a potential energy source in the brain and contributes to several cognitive functions, such as learning, memory, stress resilience, and mood regulation; However, the mechanisms by which lactate contributes to stress-induced cognitive dysfunction, including the roles of nitric oxide (NO) signaling, remain unclear. We hypothesized that lactate improves cognitive dysfunction induced by acute restraint stress via neuronal NO synthase (nNOS), a major NO source in the central nervous system, and the brain-derived neurotrophic factor (BDNF) pathway. We demonstrated that lactate phosphorylates nNOS at Ser1412 and promotes the neural differentiation of Neuro2a, a mouse neuroblastoma cell line. These effects were attenuated by the monocarboxylate transporter (MCT) 1/2-selective inhibitor AR-C155858 or the nNOS-selective inhibitor 7-nitroindazole. In C57BL/6 J mice, intraperitoneal lactate administration (1 g/kg) increased nNOS phosphorylation and BDNF expression, specifically in the dorsal hippocampus, independent of AMPK and Akt activation. Under acute restraint stress conditions, prior lactate administration protected against working memory impairment as measured using the Y-maze test, and nNOS phosphorylation and BDNF expression increased in the dorsal hippocampus. However, lactate administration did not mitigate acute stress-induced anxiety-like behaviors, as assessed through the elevated plus maze test, nor did it significantly alter NO signaling in the ventral hippocampus. These findings provide evidence supporting the partial therapeutic role of elevated blood lactate concentrations, whether induced by nutrition or physiological activities, such as exercise, in mitigating cognitive dysfunction caused by acute stress.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120039"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcortical grey matter structures in relation to symptoms of depression and anxiety on the spectrum from cognitively healthy to dementia.","authors":"Ilse Vom Hofe, Annemarie I Luik, Meike W Vernooij, Esther van den Berg, Frank J Wolters","doi":"10.1016/j.jad.2025.119998","DOIUrl":"10.1016/j.jad.2025.119998","url":null,"abstract":"<p><strong>Background: </strong>Anxiety and depression are common in prodromal dementia, possibly due to changes in subcortical grey matter structures involved in emotion regulation. We aimed to determine the association between subcortical grey matter volumes and depression and anxiety symptoms.</p><p><strong>Methods: </strong>We included dementia-free participants from the population-based Rotterdam Study, who underwent brain MRI between 2009 and 2015. Depression and anxiety symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale and the Hospital Anxiety and Depression scale- Anxiety subscale (HADS-A). We determined cross-sectional associations of standardized volumes with log-transformed CES-D and HADS scores using multivariable linear regression models. We repeated analyses among outpatients who attended the Alzheimer Center Erasmus Medical Center between 2016 and 2021.</p><p><strong>Results: </strong>Among 3451 community-dwelling participants (mean age 69.3 years, 55.2 % women), median CES-D score was 3 (IQR:1-7) and HADS-A score 2 (IQR:0-4). Clinically relevant depressive symptoms (CES-D ≥ 16) were present in 284 (8.2 %) participants, and anxiety (HADS≥8) in 270 (8.2 %). Lower volumes of the caudate and pallidum were associated with fewer depressive symptoms (mean difference [95 %CI] for the caudate: -0.06[-0.10;-0.02], pallidum: -0.04[-0.08;0.00]), and less anxiety (caudate: -0.04[-0.07;-0.01], pallidum: -0.05[-0.09;-0.02]). Lower hippocampal volume was associated with higher odds of clinical depressive symptoms (OR: 1.27[1.05-1.52]), albeit not significant after multiple testing correction. We observed no associations for other structures. Among 315 memory clinic patients, (mean age 68.9 years, 43.5 % women), no associations were observed after multiple testing correction.</p><p><strong>Conclusion: </strong>Volumes of the caudate and pallidum are inversely associated with depression and anxiety symptoms in community-dwelling older adults, but not in a memory clinic population.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119998"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and impulsivity pathways in non-suicidal self-injury among bipolar disorder: A 24-week longitudinal cohort study.","authors":"Yinglin Han, Xinxin Huang, Yishan Du, Zhijian Yao","doi":"10.1016/j.jad.2025.120015","DOIUrl":"10.1016/j.jad.2025.120015","url":null,"abstract":"<p><strong>Background: </strong>Non-suicidal self-injury (NSSI) is frequently observed in patients with bipolar disorder (BD), increasing the risk of suicide. However, the longitudinal mechanisms linking inflammatory, cognitive control deficits, and impulsive to NSSI remain unclear.</p><p><strong>Methods: </strong>We conducted a 24-week longitudinal study involving 400 participants (200 BD patients with NSSI, 100 BD patients without NSSI, and 100 healthy controls), with assessments at baseline (T0), Week 12 (T1), and Week 24 (T2). Key measures included inflammatory markers (IL-6, CRP), cognitive tasks (Go/No-Go, DSST), impulsivity (BIS-11), and clinical features. Analyses involved linear mixed models, hierarchical regressions, structural equation modeling (SEM), and time-varying latent growth modeling (LGM).</p><p><strong>Results: </strong>Across a 24-week follow-up, the BD + NSSI group showed persistently elevated IL-6 and CRP levels, with IL-6 increasing significantly over time (p < 0.01). Baseline structural equation modeling (SEM) revealed a significant indirect pathway from CRP to NSSI severity via impaired cold inhibitory control (Go/NoGo task: β = 0.048, p < 0.001), while the hot inhibition pathway (CRP → DSST→NSSI) was statistically non-significant and temporally unstable. Time-varying LGM further indicated that cold inhibition mediated the effects of both CRP and IL-6 on NSSI in the later phase (T2), supporting a delayed but progressive inflammatory impact on executive control. Exploratory moderation analyses showed that high impulsivity attenuated the indirect inflammation-NSSI pathway, suggesting a distinct impulsivity-driven subtype. These findings support a dual-pathway framework for NSSI in bipolar disorder, involving both chronic inflammation-related cognitive dysfunction and trait impulsivity mechanisms.</p><p><strong>Conclusion: </strong>These findings support a temporally distinct dual-pathway model in which acute CRP-related and chronic IL-6-mediated inflammation contribute to NSSI via cognitive and affective mechanisms in bipolar disorder.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120015"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between air pollution and dementia in mood disorders: The moderating role of sleep patterns-- A prospective study from the UK Biobank.","authors":"Rong Song, Jian Song, Jintao Liu, Ming Li, Zhiqian Cui, Yuxin Huang, Zichen Zhang, Lingmei Kuang, Chuan Li, Xin Yu, Weizhuo Yi, Rubing Pan, Xingxu Yi, Jian Cheng, Tianrong Pan, Hong Su","doi":"10.1016/j.jad.2025.120022","DOIUrl":"10.1016/j.jad.2025.120022","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to quantify dementia risk in mood disorder patients, to examine the association between air pollution and dementia risk, and to assess whether sleep patterns incorporating five specific sleep behaviors modifies this relationship.</p><p><strong>Methods: </strong>This prospective cohort study enrolled 459,635 individuals from the UK Biobank, 46,256 mood disorder patients at baseline; of those, 1494 developed dementia during follow-up. Air pollution exposure (PM_2.5, PM₁₀, PM_C, NO₂, and NO_X) was estimated using land-use regression models. Sleep patterns were defined according to five sleep domains (sleep chronotype, duration, insomnia, snoring, and daytime sleepiness), with a score ≥ 4 considered healthy. Proportional hazards regression (Cox models) was employed to assess hazard ratios (HRs) for dementia risk. Stratification methodologies were performed to evaluate modification by both individual sleep behaviors and the total sleep pattern score on PM_2.5-dementia associations.</p><p><strong>Results: </strong>Mood disorders significantly increased dementia risk (HR: 5.69, 95 %CI: 5.36-6.04, P < 0.001). Notably, a significant association with increased dementia risk was observed only for PM_2.5 (HR: 1.67 per 10 μg/m³, 95 % CI: 1.04-2.69, P = 0.034), while PM_C, PM₁₀, NO₂, and NO_X showed no significant associations after comprehensive covariate adjustment. Both five sleep domains and the sleep patterns were found to mitigate the adverse effect of PM_2.5 on dementia risk.</p><p><strong>Conclusions: </strong>This study reveals that PM_2.5 significantly increases dementia risk in mood disorder patients, while healthy sleep patterns may mitigate this effect. These findings highlight the importance of air pollution control and sleep interventions in dementia prevention to reduce dementia risk in vulnerable populations.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120022"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of depression, 1990-2021: a decomposition and age-period-cohort analysis with projection to 2040.","authors":"Qianshu Xu, Zhengxue Qiao, Yuecui Kan, Bowen Wan, Xiaohui Qiu, Yanjie Yang","doi":"10.1016/j.jad.2025.120018","DOIUrl":"10.1016/j.jad.2025.120018","url":null,"abstract":"<p><strong>Background: </strong>Depression stands as one of the leading causes of disability worldwide. This study conducts a comprehensive analysis of the global burden of depression.</p><p><strong>Methods: </strong>Based on the Global Burden of Disease (GBD), we employed Joinpoint regression to analyze trends disease burden of depression globally from 1990 to 2021. The age-period-cohort (APC) model was employed to decompose the effects of age, period, and cohort, while the Das Gupta method quantified the contributions of aging, population growth, and epidemiological changes. A Bayesian age-period-cohort (BAPC) model was further utilized to project disease burden through 2040.</p><p><strong>Results: </strong>In 2021, the global age-standardized incidence, prevalence, and DALY rates of depression increased by 15.6 %, 11.3 %, and 13.4 %, compared to 1990, with average annual percentage changes (AAPCs) of 0.5 %, 0.4 %, and 0.4 %. APC analysis identified a peak age effect at 60-64 years, the highest period risk during 2017-2021, and a continuous rise in cohort risk after 1987. Cross-national inequality analysis revealed a higher burden in low-SDI countries (SII = -1981.7 per 100,000 in 2021), alongside widening health disparities among females. Decomposition analysis indicated that population growth accounted for 43.5 %-54.2 % of the global burden increase. BAPC projections estimated that by 2040, global age-standardized incidence, prevalence, and DALY rates would rise to 8478.2, 6927.8, and 1248.1 per 100,000.</p><p><strong>Conclusions: </strong>The global burden of depression continues to rise with significant inequalities. Prioritizing women, high-growth regions, and low-SDI countries is essential to address the escalating burden. This study provides critical evidence for optimizing resource allocation and developing interdisciplinary intervention plans.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120018"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant in treating myocardial infarction complicated with depression via 5-HT/inflammation from heart to brain.","authors":"Lijun Zhang, Meiyan Liu, Haiyang Chen, Yanwei Li, Peijun Rao","doi":"10.1016/j.jad.2025.120048","DOIUrl":"10.1016/j.jad.2025.120048","url":null,"abstract":"<p><strong>Objective: </strong>Exploring the potential mechanism by which inflammation and 5-HT linking myocardial infarction (MI) and depression, and to evaluate therapeutic effect of fluoxetine and SN50.</p><p><strong>Methods: </strong>Patients with coronary artery disease (CAD) were recruited; depressive symptoms were evaluated, inflammatory factors were detected, and the effects of selective serotonin reuptake inhibitors (SSRIs) for CAD patients with depression were recorded. Furthermore, fluoxetine and SN50 were administrated separately for treatment in MI mice, SERT knockout mice, and H9C2 cell experiments.</p><p><strong>Results: </strong>CAD patients with depression had higher value of TNF-α, IL-4, IL-17, IFN-α, and IFN-γ (P < 0.05) compared to those without depression. CAD + depression patients were followed up for 2 years, those who received SSRIs treatment experienced lower cardiac events [1 events (3.7 %) vs. 14 events (11.8 %)] than those who did not. The animal experiment showed that MI surgery induced cardiac dysfunction and autonomic nerves injury which were exacerbated by excessive inflammatory response. Moreover, MI mice exhibited depressive behaviors, possibly due to autonomic nerves injury and inflammation in the cortex and hippocampus. Furthermore, fluoxetine and SN50 contributed to improving cardiac function, regulating cardiac vegetative nervous, relieving depressive behaviors, and reducing inflammation via macrophages/TNF-α/TNFR/NF-κB signaling pathway. SERT knockout mice experiment further revealed the association between 5-HT and inflammation. In addition, the H9C2 cell experiment presented demonstrated the anti-inflammatory effect of fluoxetine.</p><p><strong>Conclusion: </strong>This study identified inflammation, autonomic nerves dysfunction/5-HT as critical mechanisms of MI + depression. Antidepressant treatment would benefit both heart and brain. Moreover, anti-inflammation would be a promising approach for treating MI complicated with depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120048"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rationale for subtyping depression into atypical and melancholic in research and clinical settings: A narrative review.","authors":"Martin Preisig, Jennifer Glaus, Aurélie M Lasserre, Beatriz Pozuelo Moyano, Giorgio Pistis, Marie-Pierre F Strippoli, Caroline L Vandeleur","doi":"10.1016/j.jad.2025.120045","DOIUrl":"10.1016/j.jad.2025.120045","url":null,"abstract":"<p><strong>Background: </strong>Given the well-known heterogeneity of depression, subtyping into atypical and melancholic depression according to clinical manifestations has gained increasing interest in research, to define more homogenous groups. This narrative review focuses on studies investigating indicators of the validity of the subtyping of depression into atypical vs. melancholic, including familial aggregation patterns and course of illness as well as differences between these subtypes regarding sociodemographic, psychological and biological characteristics.</p><p><strong>Results: </strong>There is some limited evidence for the specific familial aggregation and longitudinal stability of the atypical depression subtype, but weaker evidence for the validity of the melancholic subtype. In contrast, there is good evidence, based on multiple mostly cross-sectional studies with partially large samples, to support differences between the atypical and the melancholic subtypes in sex distribution, metabolic and inflammatory marker levels and HPA-axis functioning. There is also some evidence for a differential lifetime prevalence between subtypes for comorbid anxiety and substance use disorders as well as for dietary habits.</p><p><strong>Limitations: </strong>Heterogeneity of subtype definitions and data on familial aggregation and the longitudinal stability of these subtypes is scarce.</p><p><strong>Conclusions: </strong>Although the reviewed literature provides support for subtyping into atypical and melancholic depression, the current DSM definitions of these subtypes are not optimal. In the future, an enhanced understanding of the biological pathways underlying depression should help to define subtypes or dimensions that are more closely related to their underlying biological mechanisms, thereby promoting the identification of patient subgroups that are more likely to respond to specific types of treatment.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120045"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating and moderating effects of experiential avoidance between excessive daytime sleepiness and anxiety symptoms.","authors":"Yu-Bin Ma, Xiao-Xin Niu, Zhi-Ying Yao, Yi-Ning Yan, Zi-Ang Zheng, Cun-Xian Jia","doi":"10.1016/j.jad.2025.120065","DOIUrl":"10.1016/j.jad.2025.120065","url":null,"abstract":"<p><strong>Background: </strong>Anxiety symptoms (AS) are prevalent among college students and are associated with various negative outcomes. Excessive daytime sleepiness (EDS) is also prevalent in this group, with some studies suggesting a possible association with AS, though the underlying mechanisms remain unclear. Experiential avoidance (EA), which reflects individuals' unwillingness to remain in contact with negative experiences, may play a mediating or moderating role in this relationship. This study aims to explore these potential roles of EA to inform future interventions targeting sleep and emotion regulation.</p><p><strong>Methods: </strong>A total of 4835 college students participated in the study. The questionnaires were distributed and collected via the QuestionStar platform. The study used logistic regression to test the association between EDS, EA and AS in college students. The mediation model and moderated effects were tested using bias-corrected percentile bootstrapping.</p><p><strong>Results: </strong>44.5 % of college students reported AS, and 35.1 % experienced EDS. Both EDS (OR = 1.11; 95 %CI: 1.09-1.13) and EA (OR = 1.13; 95 %CI: 1.12-1.14) were associated with AS. Additionally, EA negatively moderated the association between EDS and AS (β = -0.002, P < 0.001). EA also partially mediated this association, accounting for 44.07 % of the total effect. No significant gender differences were observed in the moderated mediation model.</p><p><strong>Conclusions: </strong>AS and EDS were prevalent among college students. EA mediated and weakened the association between EDS and AS. Targeting EA through interventions like ACT may reduce AS and improve sleep-related outcomes.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120065"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of electroconvulsive therapy on cognitive function, depressive symptoms, and suicidal ideation in adolescents with major depressive disorder: A prospective observational study.","authors":"Renqin Hu, Junyao Li, Huirong Luo, Yanwei Guo, Jinglan Tan, Shuaichen Li, Qinghua Luo","doi":"10.1016/j.jad.2025.120092","DOIUrl":"10.1016/j.jad.2025.120092","url":null,"abstract":"<p><strong>Background: </strong>Adolescent depression and suicide are significant issues, with insufficient solutions available. Concerns about electroconvulsive therapy (ECT)'s cognitive side effects have restricted its use in adolescents with major depressive disorder (MDD). Clarifying ECT's cognitive, antidepressant, and anti-suicidal effects is crucial to inform its clinical application.</p><p><strong>Methods: </strong>This prospective observational study enrolled 60 adolescents with DSM-5-diagnosed MDD and scheduled for bifrontal ECT, between October 2023 and March 2025. Cognitive outcomes were assessed using the Cambridge Neuropsychological Test Automated Battery, and clinical outcomes using the 24-item Hamilton Depression Rating Scale (HAMD-24) and the Beck Scale for Suicide Ideation (BSI). Assessments were conducted at four points: before ECT (T0), and at 1 day (T1), 2 weeks (T2), and 4 months after ECT courses(T3).</p><p><strong>Result: </strong>Cognitive assessments showed mild declines in spatial and verbal memory at T1 (d = 0.376 and 0.364, respectively), which recovered by T2. Working memory, attention, and executive function did not decline at T1; instead, improvements emerged in 2 weeks and persisted at 4 months. No prolonged cognitive impairment was observed after four months. Following the ECT course, depressive symptoms significantly decreased (d = 4.20), with 78.3 % response and 25.0 % remission. Suicidal ideation also showed a marked reduction (d = 2.70). Other adverse events were generally mild and transient, with headaches being most frequent (58.3 %).</p><p><strong>Conclusion: </strong>ECT was associated with transient impairments in specific cognitive domains, but prolonged impairments were not observed. Additionally, ECT provides a rapid and powerful effect for depressive symptoms and suicidal ideation in adolescents. Therefore, in adolescents with MDD and elevated suicide risk, early consideration of ECT may be warranted.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120092"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of self-directed violence among traumatic stress correlates: Network analysis and comparison in veteran men and women.","authors":"Rachel L Zelkowitz, Emma K Knutson, Shannon Kehle-Forbes, Brian N Smith, Karen S Mitchell","doi":"10.1016/j.jad.2025.120017","DOIUrl":"10.1016/j.jad.2025.120017","url":null,"abstract":"<p><p>Suicidal self-directed violence (SDV) is elevated among those exposed to trauma, making it critical to understand how features of traumatic stress relate to SDV outcomes. We used network analysis to identify the associations of three SDV outcomes (recent suicidal ideation, recent suicide planning, lifetime suicide attempt) with other correlates of traumatic stress in two samples of U.S. veterans. Sample 1 included veterans from any service era (N = 911, 53.0 % women), and Sample 2 encompassed veterans from the post-9/11 era who had recently separated from service (N = 1089, 57.0 % women). Participants self-reported current posttraumatic stress disorder (PTSD) symptoms, depressive symptoms, and risky/self-destructive behaviors (i.e., nonsuicidal self-injury, binge drinking, drug use, binge eating, purging, excessive exercise, and fasting). We estimated networks using mixed graphical models and identified edges connecting correlates to SDV outcomes in each sample. The PTSD symptom cluster of negative alterations in cognitions and mood, depressive symptoms and nonsuicidal self-injury consistently emerged as correlates of SDV outcomes. We used the network comparison test to compare network strength, structure, and SDV connections across samples and between veteran men and women. We found no evidence to support differences in network strength or structure across samples. The network structure differed significantly for men compared to women (M = 0.193, p = .017), but network strength did not differ between these groups. Similarly, connections to SDV outcomes did not differ between veteran men and women. Findings suggest the importance of targeting specific correlates of traumatic stress to ameliorate SDV risk.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"120017"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}