Journal of affective disorders最新文献

{"title":"Childhood maltreatment and parenting style moderate the mediation of resilience in the continuity of anxious and depressive symptoms in Chinese children and adolescents","authors":"Die Fang ,&nbsp;Jin Lu ,&nbsp;Hailiang Ran ,&nbsp;Yandie He ,&nbsp;Guiqing Zheng ,&nbsp;Shuqing Liu ,&nbsp;Yi Xiang ,&nbsp;Xiang Wang ,&nbsp;Xinyi Liu ,&nbsp;Yuanyuan Xiao ,&nbsp;Ying Chen","doi":"10.1016/j.jad.2025.119946","DOIUrl":"10.1016/j.jad.2025.119946","url":null,"abstract":"<div><h3>Background</h3><div>Existing studies suggest that resilience may play as a significant mediator in the continuity of depressive and anxious symptoms in youth, however, longitudinal evidence is lacking. Besides, whether childhood maltreatment (CM) and parenting styles significantly moderate this mediation of resilience has not been discussed before.</div></div><div><h3>Methods</h3><div>This population-based longitudinal study included 5218 participants from the Mental Health Survey for Children and Adolescents in Yunnan (MHSCAY), with a baseline survey (T₁) and 2 rounds of follow-up (T₂ and T₃). Univariate and multivariate logistic regression models were used to examine the continuity in depressive and anxious symptoms. Path analysis was adopted to estimate the mediation of resilience in the continuity of depressive and anxious symptoms. Stratified analysis was performed to test the moderation by CM and parenting styles in the mediation of resilience.</div></div><div><h3>Results</h3><div>Depressive and anxious symptoms at T₁ significantly predicted depressive and anxious symptoms at T₃ (adjusted OR for depressive symptoms: 3.35, 95 % CI: 2.85–3.93; adjusted OR for anxious symptoms: 3.31, 95 % CI: 2.76–3.99). Resilience mediated 18.96 % of the continuity in depressive symptoms and 19.51 % of the continuity in anxious symptoms, and the mediation was stronger for internal resilience factors. CM and parenting styles significantly moderated the mediation of resilience, with a stronger mediation found in individuals who had experienced CM, parental overprotection or parental rejection.</div></div><div><h3>Conclusions</h3><div>Resilience-based interventions could be useful in breaking the continuity of depressive and anxious symptoms in children and adolescents. Particularly for those who were exposed to CM or negative parenting styles.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119946"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifractal-dynamic reliability of white matter in rs-fMRI and relationships to gray matter","authors":"Sihai Guan ,&nbsp;Honglang Wei ,&nbsp;Chun Meng ,&nbsp;Bharat Biswal","doi":"10.1016/j.jad.2025.119932","DOIUrl":"10.1016/j.jad.2025.119932","url":null,"abstract":"<div><div>Recent studies have demonstrated the reliable detection and analysis of white matter (WM) using the resting-state functional magnetic resonance imaging (rs-fMRI) signal. This paper studies the multifractal spontaneous in WM based on the HCP test-retest datasets. Precisely: (1) multifractal in the WM; (2) the source of multifractal; (3) difference and similarity between the multifractal of WM and gray matter (GM). Results showed that WM appears to be multifractal and significantly different from GM, but the variability of brain regions in WM was smaller than that in GM. For example, in WM, (‘Fornix’, ‘Inferior cerebellar peduncle L’, ‘Superior cerebellar peduncle R’, ‘Posterior corona radiata R’, and ‘Uncinate fasciculus L’) had higher multifractal scores than other regions; but in GM, the degree of multifractal in the parietal lobe, occipital lobe, and parietal lobe was higher than that of different regions. Besides, the source of multifractality is primarily composed of heavy-tailed probability distributions and long-range dependence, particularly heavy-tailed probability distributions. In addition, the ICC of multifractal in GM or WM increases with the increase of sample points, but the growth trend decreases. The ICC of multifractal in GM or WM decreased with the rise of the subject numbers, but when this number was &gt;36, the ICC did not significantly change. Besides, the ICC value of multifractal in GM and WM did not change significantly with the change of smooth size between 4 mm, 6 mm, and 8 mm full-width half-maximum. The results provide a reference for understanding the spontaneous neuronal fluctuations in WM.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119932"},"PeriodicalIF":4.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between multimorbidity trajectories and subsequent cognitive decline: evidence from two nationwide longitudinal cohorts","authors":"Linlin Wang ,&nbsp;Yiling Lou ,&nbsp;Qingqing Jiang ,&nbsp;Hengchang Wang ,&nbsp;Shen Huang ,&nbsp;Yulin Xie ,&nbsp;Furong Wang ,&nbsp;Shiyi Cao","doi":"10.1016/j.jad.2025.119958","DOIUrl":"10.1016/j.jad.2025.119958","url":null,"abstract":"<div><h3>Background</h3><div>The number of chronic diseases in a patient may change over time, but how multimorbidity developmental trajectories affect subsequent cognitive decline remains unknown.</div></div><div><h3>Methods</h3><div>Data were drawn from eight waves (2004–2018) of the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS), involving 5300 and 4357 participants, respectively. Group-based trajectory modeling was used to identify multimorbidity trajectories over six years (2004–2010) according to ten chronic diseases. We performed linear mixed-effects models to investigate the association between multimorbidity trajectories and subsequent cognitive decline in global cognition and three cognitive domains, including memory, executive function, and orientation.</div></div><div><h3>Results</h3><div>Three multimorbidity trajectories (low-stable, moderate-increasing, and rapid-increasing) were identified in two cohorts. Compared to the low-stable trajectory group, the moderate-increasing trajectory group exhibited faster declines in memory [pooled <em>β</em> = −0.027 standard deviation (SD)/year, 95 % confidence interval (CI): −0.044 to −0.011], orientation (pooled <em>β</em> = −0.036 SD/year, 95 % CI: −0.066 to −0.006), and global cognition (pooled <em>β</em> = −0.043 SD/year, 95 % CI: −0.084 to −0.002). Furthermore, the rapid-increasing trajectory group was associated with steeper declines in memory (pooled <em>β</em> = −0.049 SD/year, 95 % CI: −0.084 to −0.015), executive function (pooled <em>β</em> = −0.044 SD/year, 95 % CI: −0.065 to −0.022), orientation (pooled <em>β</em> = −0.077 SD/year, 95 % CI: −0.116 to −0.037), and global cognition (pooled <em>β</em> = −0.138 SD/year, 95 % CI: −0.211 to −0.065).</div></div><div><h3>Limitations</h3><div>Limited by the structure of questionnaire, some of the information was derived by self-report, which may lead to recalling bias.</div></div><div><h3>Conclusions</h3><div>Both moderately and rapidly increased multimorbidity are associated with accelerated cognitive decline among older people. Multimorbidity surveillance and management might help to delay the decline rate of cognition.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119958"},"PeriodicalIF":4.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on Moore et al. (2025): Is it premature to conclude that psychotherapy adds no benefit to ketamine for depression or PTSD?","authors":"Albert Yeung,&nbsp;David Mischoulon","doi":"10.1016/j.jad.2025.119959","DOIUrl":"10.1016/j.jad.2025.119959","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119959"},"PeriodicalIF":4.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Association between weight-adjusted waist index and mortality: The mediative role of depressive symptoms","authors":"Yanting Jiang ,&nbsp;Qixing Xia ,&nbsp;Qiang Liu","doi":"10.1016/j.jad.2025.119962","DOIUrl":"10.1016/j.jad.2025.119962","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119962"},"PeriodicalIF":4.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between depressive symptoms and all-cause and cardiovascular mortality in diabetes patients: A national cohort study","authors":"Zheng Zhang ,&nbsp;Huijie Xu ,&nbsp;Yun Meng ,&nbsp;Yangxinyu Yan ,&nbsp;Yuanyuan Wang","doi":"10.1016/j.jad.2025.119957","DOIUrl":"10.1016/j.jad.2025.119957","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a significant psychological burden frequently observed among diabetic patients, and it has been increasingly linked to higher mortality risks, particularly from cardiovascular diseases. Clarifying why depression contributes to these risks is essential for effective intervention strategies.</div></div><div><h3>Methods</h3><div>This national cohort study utilized data from the National Health and Nutrition Examination Survey (NHANES) (2005–2018), analyzing 4743 diabetic patients. Depressive symptoms were assessed using the PHQ-9 scale, and mortality data were linked through the National Death Index. The Systemic Immune-Inflammation Index (SII) was calculated to evaluate its mediating role in the relationship between depressive symptoms and mortality.</div></div><div><h3>Results</h3><div>Depressive symptoms significantly increased all-cause (HR = 1.32, 95 % CI = 1.07–1.63) and cardiovascular mortality (HR = 1.73, 95 % CI = 1.23–2.42) even after adjustments. SII mediated 8.0 % of the association with all-cause mortality and 6.0 % with cardiovascular mortality. Subgroup analyses revealed varied impacts based on demographic characteristics.</div></div><div><h3>Conclusion</h3><div>Depressive symptoms are linked to heightened mortality risks in diabetic patients, with SII serving as a critical mediating factor. Comprehensive management addressing both mental health and inflammation is essential for improving outcomes in this population.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119957"},"PeriodicalIF":4.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between marital status and risk for suicidal thoughts, plans, and attempts: Evidence for a growing association.","authors":"Stephen Cranney, Samuel T Wilkinson","doi":"10.1016/j.jad.2025.119862","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119862","url":null,"abstract":"<p><strong>Background: </strong>Suicide is a public health crisis. Marital status has long been associated with a reduced suicide risk, though the culture and prevalence of marriage has changed substantially over previous decades. This report investigates whether the association of marriage and risk changed from 2008 to 2019.</p><p><strong>Methods: </strong>Using data from the National Survey of Drug Use and Health (NSDUH), the association between marital status and risk of suicidal thoughts, plans and attempts in the previous year are analyzed. Interaction effects (time by marital status by sex) are tested in hierarchical regression models.</p><p><strong>Results: </strong>Unadjusted data show that unmarried individuals are approximately three times more likely than married individuals to think about, plan, and/or attempt a suicide (all ps < .001) at any given point in time. This relationship holds after controlling for age, sex, race, income, religious observance, and education. The protective association of marriage is growing (with a year by married status odds ratio of 0.95-0.97 [p < .01]), a trend driven by the never married (as opposed to divorced or widowed individuals); never-married individuals are at increasing risk over time (all p < .001) for all outcomes observed (suicidal thoughts, plans, attempts).</p><p><strong>Conclusion: </strong>The protective association of marriage against risk of suicidal thoughts, plans and attempts is growing at a time when many young people have de-prioritized marriage as an important life goal. Increased clinical attention may be warranted for individuals who are not married, especially those who have other significant risk factors for suicide.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119862"},"PeriodicalIF":4.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an Australian Clinical Practice Guideline on methylenedioxymethamphetamine (MDMA)-assisted Psychotherapy for Post-traumatic Stress Disorder.","authors":"Alene Sze Jing Yong, Sue E Brennan, Suzie Bratuskins, Aimee Freeburn, Gillinder Bedi, Rimona Burke, Mary Hollick, Kimberley Ann Jones, Andrew J Lawrence, Yong Yi Lee, Alexander C McFarlane, Stephen Parker, Nicholas Procter, Liam Spicer, Andrew A Somogyi, Simon Stafrace, Stacey Watts, Clare Walton, Kay Wilson, J Simon Bell","doi":"10.1016/j.jad.2025.119866","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119866","url":null,"abstract":"<p><strong>Introduction: </strong>Despite recent clinical and research interest, medical use of psychedelics has not been legalised in most jurisdictions. The Australian Therapeutic Goods Administration rescheduled methylenedioxymethamphetamine (MDMA) in July 2023 to permit authorised prescribing of MDMA for Post-traumatic Stress Disorder (PTSD) outside of the clinical trial setting.</p><p><strong>Objective: </strong>This manuscript describes the development of the Australian Clinical Practice Guideline on MDMA-assisted psychotherapy (MDMA-AP) for PTSD.</p><p><strong>Methods: </strong>The Guideline will be developed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) process. The Guideline will consider the benefits and harms of MDMA-AP compared to other treatments in people with PTSD. High quality systematic reviews identified via an overview of systematic reviews will be used as index and supplementary reviews. Using the GRADE Evidence-to-Decision framework, the multidisciplinary Guideline Development Group (GDG) will consider treatment benefits and harms, certainty of evidence, patient preferences and values, resources, equity, acceptability and feasibility. The GDG will be supported by a Stakeholder Group, Expert Group, Conflict of Interest Oversight Committee, and Evidence Review Team. The Guideline will be developed using an integrated knowledge translation approach, emphasising the co-production of knowledge through active participation and shared decision-making with end-users.</p><p><strong>Conclusion: </strong>The Guideline will be published on the digital platform MAGICapp and disseminated in peer-reviewed publications, professional conferences and via specific stakeholder groups. A Companion Guide will be developed for people living with PTSD and their carers, family members, and supports.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119866"},"PeriodicalIF":4.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based detection of depression by fusing auditory, visual and textual clues","authors":"Chenyang Xu ,&nbsp;Yangbin Chen ,&nbsp;Yanbao Tao ,&nbsp;Wanqing Xie ,&nbsp;Xiaofeng Liu ,&nbsp;Yunhan Lin ,&nbsp;Chunfeng Liang ,&nbsp;Fan Du ,&nbsp;Zhixiong Lin ,&nbsp;Chuan Shi","doi":"10.1016/j.jad.2025.119860","DOIUrl":"10.1016/j.jad.2025.119860","url":null,"abstract":"<div><h3>Background</h3><div>Early detection of depression is crucial for implementing interventions. Deep learning-based computer vision (CV), semantic, and acoustic analysis have enabled the automated analysis of visual and auditory signals.</div></div><div><h3>Objective</h3><div>We proposed an automated depression detection model based on artificial intelligence (AI) that integrated visual, auditory, and textual clues. Moreover, we validated the model's performance in multiple scenarios, including interviews with chatbot.</div></div><div><h3>Methods</h3><div>A chatbot for depressive symptom inquiry powered by GPT-2.0 was developed. The brief affective interview task was designed as supplement. Audio-video and textual clues were captured during interview, and features from different modalities were fused using a multi-head cross-attention network. To validate the model's generalizability, we performed external validation with an independent dataset.</div></div><div><h3>Results</h3><div>(1)In the internal validation set (152 depression patients and 118 healthy controls), the multimodal model demonstrated strong predictive power for depression in all scenarios, with an area under the curve (AUC) exceeding 0.950 and an accuracy over 0.930. Under the symptomatic interview by chatbot scenario, the model showed exceptional performance, achieving an AUC of 0.999. Specificity decreases slightly (0.883) in the Brief Affective Interview Task. The multimodal model outperformed unimodal and bimodal counterparts. (2)For external validation under the symptomatic interview by chatbot scenario, a geographically distinct dataset (55 depression patients and 45 healthy controls) was employed. The multimodal fusion model achieved an AUC of 0.978, though all modality combinations exhibited reduced performance compared to internal validation.</div></div><div><h3>Limitations</h3><div>Longitudinal follow-up was not conducted in this study, and severe depression applicability requires further study.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119860"},"PeriodicalIF":4.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inconclusive evidence for a prospective effect of sense of coherence on subjective burden and mental health: A simulated reanalysis and comment on Gonçalves-Pereira et al. (2025)","authors":"Kimmo Sorjonen ,&nbsp;Bo Melin","doi":"10.1016/j.jad.2025.119939","DOIUrl":"10.1016/j.jad.2025.119939","url":null,"abstract":"<div><div>Based on findings from analyses with cross-lagged panel models, <span><span>Gonçalves-Pereira et al. (2025)</span></span> suggested causal effects of sense of coherence (SOC) on subjective burden, anxiety, and depression among family caregivers. Here, we simulated data to resemble the data used by Gonçalves-Pereira et al. We used triangulation and fitted complementary models to the simulated data and found contradicting increasing, decreasing, and null effects of initial sense of coherence on subsequent change in subjective burden and mental health. These divergent findings indicated that it is premature to assume causal effects of sense of coherence on subjective burden and mental health and the suggestions by Gonçalves-Pereira et al. in this regard can be challenged. It is important for researchers to be aware that correlations, including adjusted cross-lagged effects, do not prove causality in order not to overinterpret findings, something that appears to have happened to Gonçalves-Pereira et al. We recommend researchers to triangulate by fitting complementary models to their data in order to evaluate if analyzed data could be used to support contradicting conclusions, in which case the data should not be used to support any of those conclusions.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119939"},"PeriodicalIF":4.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}