Journal of affective disorders最新文献

{"title":"Prevalence and sociodemographic configurations of anxiety and depression among caregivers of individuals with mental illness: A meta-analysis and qualitative comparative analysis","authors":"Yubin Chen ,&nbsp;Linghui Zhang ,&nbsp;Shuxin Zhang ,&nbsp;Jiayuan Zhang ,&nbsp;Hong Yu ,&nbsp;Qi Li ,&nbsp;Yuqiu Zhou","doi":"10.1016/j.jad.2025.01.129","DOIUrl":"10.1016/j.jad.2025.01.129","url":null,"abstract":"<div><h3>Background</h3><div>Caring for individuals with mental illness involves significant challenges from both the unique symptoms and societal stigma associated with these conditions, often leading to caregiver neglect despite the heightened risk of anxiety and depression among caregivers. This study was designed to quantify the prevalence of anxiety and depression among caregivers and to offer a detailed configurational analysis of their sociodemographic attributes.</div></div><div><h3>Methods</h3><div>Random-effects meta-analyses were conducted using generalized linear mixed models to calculate the prevalence rates for each study. We explored potential sources of heterogeneity through meta-regression and subgroup analyses. Qualitative Comparative Analysis (QCA) was utilized to identify sociodemographic configurations that contribute to anxiety and depression. The study was pre-registered in PROSPERO (CRD42023478003).</div></div><div><h3>Results</h3><div>A total of 52 studies involving 10,232 participants were included. The prevalence of depression was 43.91 % (95 % CI: 34.62 %–53.65 %), anxiety was 66.56 % (95 % CI: 48.45 %–80.82 %), and comorbidity was 37.24 % (95 % CI, 19.75 %–58.85 %). QCA identified four sociodemographic configurations contributing to depression and two contributing to anxiety. Key contributors to depression included younger, unmarried, highly educated female caregivers, as well as older, married caregivers caring for patients with schizophrenia. Anxiety was more prevalent among older, married caregivers of patients with schizophrenia and younger, highly educated female caregivers.</div></div><div><h3>Limitations</h3><div>Differences in the measurement tools used across studies may have impacted the results of this study.</div></div><div><h3>Conclusions</h3><div>The high prevalence of depression and anxiety among caregivers of individuals with mental illness underscores the need for targeted mental health services and policies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 486-495"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide Mendelian randomization mapping the influence of plasma proteome on major depressive disorder","authors":"Chong Li ,&nbsp;Kunxue Zhang ,&nbsp;Jiubo Zhao","doi":"10.1016/j.jad.2025.01.140","DOIUrl":"10.1016/j.jad.2025.01.140","url":null,"abstract":"<div><div>Plasma proteins play critical roles in a series of biological processes and represent a major source of translational biomarkers and drug targets. In this study, we performed Mendelian randomization (MR) to explore potential causal associations of protein quantitative trait loci (pQTL, <em>n</em> = 54,219) with major depressive disorder (MDD) using summary statistics from the PGC (<em>n</em> = 143,265) and further replicated in FinnGen cohort (<em>n</em> = 406,986). Subsequently, gene expression quantitative trait loci (eQTL) of identified proteins were leveraged to validate the primary findings in both PGC and FinnGen cohorts. We implemented reverse causality detection using bidirectional MR analysis, Steiger test, Bayesian co-localization and phenotype scanning to further strengthen the MR findings. In primary analyses, MR analysis revealed 2 plasma protein significantly associated with MDD risk at Bonferroni correction (<em>P</em> &lt; 3.720 × 10–5), including butyrophilin subfamily 2 member A1 (BTN2A1, OR = 0.860; 95 % CI, 0.825–0.895; <em>P</em> = 1.79 × 10–5) and butyrophilin subfamily 3 member A2 (BTN3A2, OR = 1.071; 95 % CI, 1.056–1.086; <em>P</em> = 3.89 × 10–6). Both the identified proteins had no reverse causality. Bayesian co-localization indicated that BTN2A1 (coloc.abf-PPH4 = 0.620) and BTN3A2 (coloc.abf-PPH4 = 0.872) exhibited a shared variant with MDD, a finding that was subsequently validated by HEIDI test. In the replication stage, BTN2A1 and BTN3A2 were successfully validated in the FinnGen cohort. This study genetically determined BTN2A1 and BTN3A2 were associated with MDD and these findings may have clinical implications for MDD prevention.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 1-9"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional relationship between afternoon naps and depressive symptoms in Chinese middle-aged and older adults: Evidence from a nationally representative cohort study","authors":"Bowen Qin ,&nbsp;Zhe Li ,&nbsp;Guozhi Xia ,&nbsp;Xu Wang ,&nbsp;Ruhai Bai","doi":"10.1016/j.jad.2025.01.122","DOIUrl":"10.1016/j.jad.2025.01.122","url":null,"abstract":"<div><h3>Background</h3><div>Limited studies have investigated the association between depressive symptoms and napping habits. In this study, nationally representative data from the China Health and Retirement Longitudinal Study (CHARLS) were employed to conduct cross-sectional and longitudinal analyses to investigate their associations among Chinese middle-aged and older adults.</div></div><div><h3>Methods</h3><div>The study included 12,208 participants from the 2015 CHARLS. Depressive symptoms were measured using the Depression Scale. Napping duration was categorized into four groups: no napping (0 min), short (&lt;30 min), moderate (30–89 min), and prolonged (≥90 min). Logistic regression analysis was used to assess bidirectional relationships, and dose–response patterns were analyzed via restricted cubic splines (RCS).</div></div><div><h3>Results</h3><div>A total of 2487 participants (32.0 %) developed new-onset depressive symptoms, and moderate napping group exhibited the lowest incidence rate. Statistical analysis revealed that moderate napping was a protective factor for the depressive symptoms (OR, 95 % CI, 0.689, 0.567–0.843). A total of 1742 participants (42.3 %) newly experienced poor napping, and the incidence of poor napping gradually rose by the increase of the CES-D-10 score quartiles. Moreover, depressive symptoms were also found to be a risk factor for poor napping (OR, 95 % CI, 1.149, 1.004–1.314). The RCS model revealed that there was an approximately U-shaped association between nap duration and depressive symptoms, and there was a negative linear association between CES-D-10 scores and nap duration.</div></div><div><h3>Limitation</h3><div>The observational design limits ruling out unobserved confounding factors.</div></div><div><h3>Conclusion</h3><div>There was a significant bidirectional relationship and a dose–response association between napping and depressive symptoms in middle-aged and older adults.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 380-389"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-scale digital phenotyping: Identifying depression and anxiety indicators in a general UK population with over 10,000 participants","authors":"Yuezhou Zhang ,&nbsp;Callum Stewart ,&nbsp;Yatharth Ranjan ,&nbsp;Pauline Conde ,&nbsp;Heet Sankesara ,&nbsp;Zulqarnain Rashid ,&nbsp;Shaoxiong Sun ,&nbsp;Richard J.B. Dobson ,&nbsp;Amos A. Folarin","doi":"10.1016/j.jad.2025.01.124","DOIUrl":"10.1016/j.jad.2025.01.124","url":null,"abstract":"<div><h3>Background</h3><div>Digital phenotyping offers a novel and cost-efficient approach for managing depression and anxiety. Previous studies, often limited to small-to-medium or specific populations, may lack generalizability.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis of data from 10,129 participants recruited from a UK-based general population between June 2020 and August 2022. Participants shared wearable (Fitbit) data and self-reported questionnaires on depression, anxiety, and mood via a study app. We examined correlations between mental health scores and wearable-derived features, demographics, health variables, and mood assessments. Unsupervised clustering was used to identify behavioural patterns associated with depression and anxiety. Furthermore, we employed XGBoost machine learning models to predict depression and anxiety severity and compared the performance using different subsets of features.</div></div><div><h3>Results</h3><div>We observed significant associations between the severity of depression and anxiety with several factors, including mood, age, gender, BMI, sleep patterns, physical activity, and heart rate. Clustering analysis revealed that participants simultaneously exhibiting lower physical activity levels and higher heart rates reported more severe symptoms. Prediction models incorporating all types of variables achieved the best performance (R² = 0.41, MAE = 3.42 for depression; R² = 0.31, MAE = 3.50 for anxiety) compared to those using subsets of variables. Several wearable-derived features were observed to have non-linear relationships with depression and anxiety in the prediction models.</div></div><div><h3>Limitations</h3><div>Data collection during the COVID-19 pandemic may introduce biases.</div></div><div><h3>Conclusion</h3><div>This study identified several indicators for depression and anxiety and highlighted the potential of digital phenotyping and machine learning technologies for rapid screening of mental disorders in general populations.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 412-422"},"PeriodicalIF":4.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of physical activity in the association between ADHD and emotional dysregulation","authors":"Narda Ontiveros ,&nbsp;Camilla A. Wiklund ,&nbsp;Anna Ohlis ,&nbsp;Örjan Ekblom","doi":"10.1016/j.jad.2025.01.127","DOIUrl":"10.1016/j.jad.2025.01.127","url":null,"abstract":"<div><h3>Background</h3><div>Emotional dysregulation (ED) represents a burden for individuals with ADHD. Physical activity (PA) is associated with improvements in emotion regulation, but knowledge is limited regarding its role in ED in the context of ADHD. This study aimed to increase understanding of the association between ADHD and ED and to explore the role of PA. Identifying modifiable risk factors could aid the design of future interventions.</div></div><div><h3>Methods</h3><div>Children from the Swedish Twin Registry were included. ADHD symptoms and PA intensity and frequency were measured using parent-reported questionnaires at age 9/age 12. ED was assessed through questionnaires at age 15. The association between ADHD and ED was assessed through linear GEE regression models. Interaction terms and stratified analyses by level of PA were used to explore the role of PA. Analyses were done separately for boys and girls.</div></div><div><h3>Results</h3><div>12,094 children (52 % girls) were included. A positive association between ADHD symptoms and ED remained significant after adjusting for mental comorbidities and unmeasured family-shared confounders (β = 0.07, 95% CI 0.02–0.12 in boys; β = 0.09, 95% CI 0.02–0.16 in girls). The association was driven by inattention in boys but combined symptoms in girls. The association remained in all strata of PA. A significant interaction between PA frequency and ADHD symptoms was observed among boys (<em>p</em> = 0.02).</div></div><div><h3>Limitations</h3><div>Results were based on parent-reported PA; findings might differ with sensor-based measurements.</div></div><div><h3>Conclusion</h3><div>Higher ADHD symptoms in childhood were associated with greater ED in adolescence in all PA levels. Low PA frequency intensified the association among boys.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 68-75"},"PeriodicalIF":4.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do young-old and old-old adults benefit from cognitive-behavioral therapy compared to working-age adults? A large multicenter naturalistic study","authors":"Nicolas Wrede ,&nbsp;Mareike C. Hillebrand ,&nbsp;Anne Katrin Risch ,&nbsp;Georg W. Alpers ,&nbsp;Stephan Bartholdy ,&nbsp;Eva-Lotta Brakemeier ,&nbsp;Anne-Kathrin Bräscher ,&nbsp;Timo Brockmeyer ,&nbsp;Hanna Christiansen ,&nbsp;Monika Equit ,&nbsp;Lydia Fehm ,&nbsp;Thomas Forkmann ,&nbsp;Julia Glombiewski ,&nbsp;Jens Heider ,&nbsp;Sylvia Helbig-Lang ,&nbsp;Andrea Hermann ,&nbsp;Christiane Hermann ,&nbsp;Jürgen Hoyer ,&nbsp;Tina In-Albon ,&nbsp;Tim Klucken ,&nbsp;Gabriele Wilz","doi":"10.1016/j.jad.2025.01.145","DOIUrl":"10.1016/j.jad.2025.01.145","url":null,"abstract":"<div><h3>Background</h3><div>Although meta-analyses suggest comparable efficacy of cognitive-behavioral therapy (CBT) in older adults compared to working-age adults, little is known about its effectiveness in naturalistic settings across different age groups. Hence, this study compared symptom change, attrition rates, and treatment duration in outpatient CBT between working-age adults (18–64 years), young-old adults (65–74 years), and old-old adults (≥ 75 years).</div></div><div><h3>Methods</h3><div>We analyzed a large naturalistic dataset comprising 9081 patients between 18 and 96 years receiving outpatient CBT in Germany. Using propensity score matching, we examined differences in treatment response, remission, attrition, and duration between comparable groups of working-age, young-old, and old-old adults.</div></div><div><h3>Results</h3><div>Response and remission rates did not differ between the three age groups in terms of the Brief Symptom Inventory (BSI-53) and patient- and clinician-rated subjective improvement (CGI-I). Young-old and old-old adults showed lower rates of response and remission on the Beck Depression Inventory (BDI-II). These differences were limited to items assessing somatization, which may be related to normal aging. Treatment duration was shorter in young-old and old-old adults compared to working-age adults. Attrition rates did not differ.</div></div><div><h3>Limitations</h3><div>The samples of older adults were relatively small and probably selective. Especially, home-bound, vulnerable older adults may be underrepresented. Further, the observational study design limits interpretability of findings.</div></div><div><h3>Conclusions</h3><div>Young-old and old-old adults seem to benefit from outpatient CBT to a similar extent as working-age adults. Potential bias in outcome measures due to age-related somatic complaints should be acknowledged in practice and future research.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 456-464"},"PeriodicalIF":4.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network analysis of body dysmorphic and obsessive-compulsive symptoms among individuals with and without exposure to trauma","authors":"Li-Ling Song ,&nbsp;Alica J. Peel ,&nbsp;David Veale ,&nbsp;Thalia C. Eley ,&nbsp;Georgina Krebs","doi":"10.1016/j.jad.2025.01.146","DOIUrl":"10.1016/j.jad.2025.01.146","url":null,"abstract":"<div><h3>Background</h3><div>BDD and OCD symptoms often co-occur, but the associations between specific symptoms remain unclear. Furthermore, current research suggests that the clinical presentation of emotional disorders can differ in individuals who self-report exposure to trauma, but it is unclear whether this extends to BDD and OCD. The current study aimed to: (a) investigate associations between individual OCD and BDD symptoms and (b) determine whether symptom networks differ in those with self-reported trauma compared to those without self-reported trauma.</div></div><div><h3>Methods</h3><div>Participants (<em>N</em> = 3127) were drawn from the Genetic Links to Anxiety and Depression (GLAD) Study and had completed validated self-reported questionnaires to assess BDD and OCD symptoms, and childhood and adulthood experiences of trauma. Network analysis was used to investigate associations between seven BDD symptoms and six OCD symptom domains. Networks of reporters and non-reporters of lifetime trauma were compared using the network comparison test.</div></div><div><h3>Results</h3><div>BDD and OCD symptoms clustered distinctively with some bridging associations between them. The strongest bridging edges highlighted an association between three core BDD symptoms and the OCD domain of obsessional thoughts. BDD and OCD networks of reporters and non-reporters of lifetime trauma did not differ.</div></div><div><h3>Limitations</h3><div>Cross-sectional design, meaning causality cannot be inferred.</div></div><div><h3>Conclusions</h3><div>The findings suggest that BDD and OCD symptoms cluster distinctively, with some bridging associations between core BDD symptoms and obsessional thoughts. Future research is needed to understand the mechanisms underpinning this relationship.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 206-215"},"PeriodicalIF":4.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of neutrophils on the relationship between physical activity and depression: Evidence from cross-sectional study and mendelian randomization analysis","authors":"Fanchao Meng,&nbsp;Yiwei Lin,&nbsp;Tianyi Chang,&nbsp;Jia Chang,&nbsp;Lin Guan,&nbsp;Shuang Wang,&nbsp;Xu Chen,&nbsp;Fan He","doi":"10.1016/j.jad.2025.01.132","DOIUrl":"10.1016/j.jad.2025.01.132","url":null,"abstract":"<div><h3>Objective</h3><div>Physical activity (PA) is suggested to reduce the risk of depression, and inflammation is believed to play an important role in this antidepressant effect. The current study aims to investigate the effect of neutrophils, one of the most important markers of inflammation, on the relationship between PA and depression.</div></div><div><h3>Methods</h3><div>We cross-sectionally analyzed 34,317 adults who participated in the National Health and Nutrition Examination Survey. The moderation and mediation effects of neutrophils on the relationship between PA and depression were assessed using a four-way decomposition approach. Additional Mendelian Randomization (MR) analysis was conducted to validate the potential causal mediation effect.</div></div><div><h3>Results</h3><div>PA was associated with lower odds of depression [Odds Ratio (OR): 0.67; 95 % Confidence Interval (CI): 0.56–0.79] and a lower level of neutrophils (OR: 0.83; 95 % CI: 0.77–0.90). Neutrophils were associated with higher odds of depression in a non-linear manner. While neutrophils did not modify the association between PA and depression, a significant mediating effect was observed. The influence of PA and neutrophils on depression was attributed to the controlled direct effect (96 % proportion) and the pure indirect effect (2 % proportion). MR analysis did not confirm a potential causal effect.</div></div><div><h3>Conclusion</h3><div>There is a close relationship between PA, neutrophils, and depression. The effect of PA on depression did not differ among participants with different levels of neutrophils. Although neutrophils mediated the association between PA and depression, this mediating effect was not causal. Other unknown factors closely related to neutrophils may be involved in this mediating process.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 406-411"},"PeriodicalIF":4.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in group-based medical mistrust and associations with mental health symptoms during the COVID-19 pandemic","authors":"Jeremy W. Luk ,&nbsp;LaToya Sewell ,&nbsp;Bethany L. Stangl ,&nbsp;Courtney L. Vaughan ,&nbsp;Andrew J. Waters ,&nbsp;Melanie L. Schwandt ,&nbsp;David Goldman ,&nbsp;Vijay A. Ramchandani ,&nbsp;Nancy Diazgranados","doi":"10.1016/j.jad.2025.01.137","DOIUrl":"10.1016/j.jad.2025.01.137","url":null,"abstract":"<div><h3>Background</h3><div>Racial/ethnic disparities in health-related outcomes may have been exacerbated during the COVID-19 pandemic. Individuals from racial/ethnic minority groups or with a history of alcohol use disorder (AUD) may have greater medical mistrust. We examined racial/ethnic and AUD-related differences in group-based medical mistrust during the pandemic and tested whether medical mistrust dimensions were associated with mental health symptoms.</div></div><div><h3>Methods</h3><div>Two hundred and fifty participants from the National Institute on Alcohol Abuse and Alcoholism COVID-19 Pandemic Impact on Alcohol Study completed an online survey between April and July of 2022. Exploratory factor analysis and path analysis were conducted.</div></div><div><h3>Results</h3><div>Group-based medical mistrust scores were elevated among participants who identified as Non-Hispanic Black and those with a history of AUD. Two medical mistrust dimensions were found: (1) Suspicion and Lack of Provider Support, and (2) Group Disparities in Health Care. Compared to Non-Hispanic White participants, Non-Hispanic Black participants reported higher scores on the Suspicion and Lack of Provider Support dimension of medical mistrust, which was associated with higher mental health symptoms. This medical mistrust dimension was also a significant mediator of the observed group differences in mental health symptoms.</div></div><div><h3>Limitations</h3><div>Cross-sectional data, aggregation of racial/ethnic groups with small sample sizes, and nonrepresentative sample.</div></div><div><h3>Conclusions</h3><div>Non-Hispanic Black individuals and individuals with AUD may be more vulnerable to mental health symptoms due to higher suspicion toward medical professionals and healthcare systems and perceived lack of support from healthcare providers. Increased awareness among healthcare providers may help address medical mistrust, encourage help-seeking behaviors, and alleviate mental health symptoms.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 517-524"},"PeriodicalIF":4.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between perceived built environment and depressive symptoms in China: The mediating roles of neighborly relationships and community attachment across age-gender groups","authors":"Yizhou Pan ,&nbsp;Wanting Ren ,&nbsp;Zurong Liang","doi":"10.1016/j.jad.2025.01.130","DOIUrl":"10.1016/j.jad.2025.01.130","url":null,"abstract":"<div><h3>Background</h3><div>While prior research has linked the built environment to mental health, little attention has been given to how this relationship and its mechanisms differ at the intersection of gender and age. This study examines the direct and indirect associations between the perceived built environment and depressive symptoms, with neighborly relationships and community attachment as mediators. It also investigates how these associations vary across age-gender groups.</div></div><div><h3>Methods</h3><div>Drawing from nationally representative data from two waves of the China Family Panel Studies (<em>n</em> = 14,200), this study applied a moderated mediation model to analyze the mediating role of neighborly relationships and community attachment, as well as the moderating role of age-gender groups.</div></div><div><h3>Results</h3><div>The perceived built environment was negatively associated with depressive symptoms, and this relationship was mediated by both neighborly relationships and community attachment. Age-gender groups moderated both the direct and indirect associations, with middle-aged males exhibiting the strongest direct association, while middle-aged females demonstrated more pronounced indirect associations through social cohesion.</div></div><div><h3>Limitations</h3><div>This study relied on self-reported data to assess the built environment, and both neighborly relationships and community attachment were measured using single-item indicators, which may limit the depth of analysis. Furthermore, the observational design of the study precludes definitive causal inferences from the findings.</div></div><div><h3>Conclusions</h3><div>The study reveals varying associations between the perceived built environment and depressive symptoms across age-gender groups, with middle-aged males more affected by environmental stressors and middle-aged females benefiting from social cohesion. These findings provide insights for targeted interventions and policies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 437-447"},"PeriodicalIF":4.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}