Journal of affective disorders最新文献

{"title":"The importance of social support and food insecurity in improving outcomes for perinatal depression: A causal mediation analysis of the AFFIRM-SA trial","authors":"Nadine Seward PhD ,&nbsp;Emily Garman ,&nbsp;Thandi Davies ,&nbsp;Charlotte Hanlon ,&nbsp;Angus MacBeth ,&nbsp;Robert C. Stewart ,&nbsp;Ahmad Waqas ,&nbsp;Ricardo Araya ,&nbsp;Crick Lund","doi":"10.1016/j.jad.2025.03.159","DOIUrl":"10.1016/j.jad.2025.03.159","url":null,"abstract":"<div><h3>Background</h3><div>Understanding the mechanisms through which psychological interventions influence symptoms of perinatal depression can inform the development of interventions for improving maternal mental health. The AFFIRM-SA trial, conducted in an underserved settlement on the outskirts of Cape Town, was a task-shared psychological intervention designed to improve symptoms of perinatal depression. We aim to estimate indirect effects of mediators through which the AFFIRM-SA intervention reduced perinatal depressive symptoms.</div></div><div><h3>Methods</h3><div>Interventional Effects, a robust causal inference framework, was used to decompose the total effect of randomisation to the intervention on symptoms of perinatal depression reducing by at least 40 % on the Edinburgh Postnatal Depression Scale (EPDS) at 12 months postpartum in women with complete data (<em>n</em> = 310), into the following indirect effects at three months postpartum: experienced violence, presence of moderate or severe levels of food, and mean levels of perceived social support.</div></div><div><h3>Results</h3><div>Of the total effect of the intervention measured through the difference in EPDS scores improving by at least 40 % between treatment arms (mean difference in probability between intervention and control arm: 0.139, bias-corrected 95 % CI −0.056 to 0.224), 8 % was mediated through reduced levels of severe food insecurity (0.011; bias-corrected 95 % CI 0.003, 0.029) and 9 % through increased levels of perceived social support (0.012: bias-corrected 95 % CI: 0.001, 0.032). There was no evidence to support the mediating role of reduced levels of violence.</div></div><div><h3>Limitations</h3><div>The main limitation is the sample size (<em>n</em> = 310) which reduces the certainty of our findings where mediators are uncommon (e.g., domestic violence).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that psychological interventions that combine psychological components with interventions that directly target social determinants of mental health (such as food insecurity and social support) could substantially improve perinatal depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 552-560"},"PeriodicalIF":4.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The U-shape relationship between the aggregate index of systemic inflammation and depression in American adults: A cross-sectional study","authors":"Jiayi Duan ,&nbsp;Jianhui Chen ,&nbsp;Zhongtian Xiang","doi":"10.1016/j.jad.2025.03.139","DOIUrl":"10.1016/j.jad.2025.03.139","url":null,"abstract":"<div><h3>Background</h3><div>This investigation aims to examine the connection between the aggregate index of systemic inflammation (AISI) and depression, using data from the National Health and Nutrition Examination Survey (NHANES) database.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study using data from the NHANES collected between 2005 and 2018. Depression was assessed via the patient health questionnaire-9. To investigate the connection between AISI and the prevalence of depression, we employed weighted multivariable logistic regression models as well as restricted cubic spline (RCS) models. This study also performed subgroup and interaction analyses to further explore these associations. Additionally, threshold effect and saturation effect analyses were conducted to identify potential inflection points for AISI and depression. Finally, we compared the area under the curve (AUC) values from receiver operating characteristic (ROC) analyses to assess the diagnostic capability of the optimal model for depression.</div></div><div><h3>Results</h3><div>This study initially recruited 29,092 individuals, of whom 2596 had depression. After adjusting for potential confounders, we discovered a higher AISI was significantly linked with an higher risk of depression when comparing the highest to the lowest quantile of AISI (odds ratio: 1.205; 95 % confidence interval: 1.019–1.424; <em>P</em> = 0.032). Marital status interacted with AISI to influence the prevalence of depression (P for trend = 0.0275). The curve for participants was U-shaped, with an optimal AISI value of 828.8, and a non-linear relationship was found between AISI and depression (P for log-likelihood ratio test &lt;0.001). ROC analysis indicated that AISI had a stronger discriminative ability and accuracy in predicting depression compared to other inflammatory biomarkers.</div></div><div><h3>Conclusions</h3><div>The AISI level exhibited a U-shaped association with depression, indicating that maintaining AISI within a reasonable range may help reduce the prevalence of depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 270-278"},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between a healthy lifestyle and dementia in older adults with obesity: A prospective study in the UK biobank","authors":"Junru Wang ,&nbsp;Jiahui Zhang ,&nbsp;Yongbin Zhu ,&nbsp;Xiaojun Ma ,&nbsp;Yali Wang ,&nbsp;Kai Liu ,&nbsp;Zhuoyuan Li ,&nbsp;Jing Wang ,&nbsp;Renzhang Liang ,&nbsp;Shulan He ,&nbsp;Jiangping Li","doi":"10.1016/j.jad.2025.03.115","DOIUrl":"10.1016/j.jad.2025.03.115","url":null,"abstract":"<div><h3>Background</h3><div>The impact of adherence to low-risk lifestyle factors on dementia risk in individuals with obesity remains unclear. We aimed to explore the association between healthy lifestyles with dementia in obese participants.</div></div><div><h3>Methods</h3><div>Dementia-free participants from the UK Biobank, aged 50 years or older with obesity (BMI ≥30 kg/m²) at baseline were included. A weighted healthy lifestyle score was calculated incorporating both traditional and emerging lifestyle factors. The primary outcome was all-cause dementia and its subtypes (Alzheimer's disease and Vascular dementia). Cox regression models analyzed the association between healthy lifestyle scores and dementia risk. Restricted cubic splines tested the dose-response. We also examined the effect of lifestyle scores on dementia risk in individuals with normal weight and overweight.</div></div><div><h3>Results</h3><div>A total of 54,365 participants were included at baseline. During a median follow-up of 14.4 years, 1271 participants developed all-cause dementia, including 537 cases of Alzheimer's disease and 343 cases of vascular dementia. A 20 % increase in the lifestyle score was associated with a 7 % reduction in dementia risk (HR: 0.93; 95 % CI: 0.91,0.96) and a 4 % reduction in Alzheimer's disease risk (HR: 0.96; 95 % CI: 0.92,1.00). The association was stronger in overweight and obese participants. No significant link was found for vascular dementia.</div></div><div><h3>Limitations</h3><div>Information on lifestyle behaviors was self-reported and might be prone to measurement error.</div></div><div><h3>Conclusions</h3><div>Adherence to a healthy lifestyle may reduce the risk of dementia and Alzheimer's disease in older obese individuals, with a stronger effect observed in those with higher lifestyle scores.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 421-429"},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of maintenance pharmacotherapy in Chinese bipolar disorder patients: Guideline concordance and adjunctive medication use.","authors":"Jiansen Lin, Liu Hong, Zuowei Wang, Chuangxin Wu, Yang Li, Jia Zhou, Guiyun Xu, Miao Pan, Zhiyu Chen, Wenfei Li, Zhian Jiao, Mingli Li, Yong Zhang, Jingxu Chen, Xiuzhe Chen, Na Li, Jing Sun, Jian Zhang, Shaohua Hu, Haishan Wu, Zhaoyu Gan, Yan Qin, Yumei Wang, Yantao Ma, Xiaoping Wang, Xiaohong Li, Yuncheng Zhu, Yiru Fang","doi":"10.1016/j.jad.2025.03.096","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.096","url":null,"abstract":"<p><strong>Objective: </strong>We collected maintenance treatment medication information from Chinese multicenter bipolar disorder patients, exploring the characteristics of medication use and related factors. We analyzed medication guideline adherence and compared trends in medication use with a study from 2014.</p><p><strong>Methods: </strong>323 patients receiving maintenance therapy for bipolar disorder across 20 hospitals have been recruited. Their prescription information was collected to compare with the recommended drug protocols outlined by CANMAT to assess consistency. Additionally, descriptive statistics were conducted to document the quantities and percentages of different classes of medications used. Regression analysis was employed to explore factors influencing medication choices.</p><p><strong>Result: </strong>The rate of medication inconsistency in this study was 12.38 %, characterized by inappropriate use of antidepressants and mood stabilizers. The rate of using additional drugs was 67.80 %, with antipsychotics being the most common adjunctive treatment in the Bipolar I group and antidepressants in the Bipolar II group. Factors influencing the occurrence of adjunctive therapy included history of previous hospitalization, current or most recent episode type, and gender. The rate of polypharmacy was 47.10 %, with age at first onset and history of prior previous hospitalization and most recent episode type being the main influencing factors.</p><p><strong>Conclusion: </strong>There has been a noticeable improvement in guideline concordance in medication use compared to 2014; however, improper use of antidepressants remains a significant clinical issue. The increasing prevalence of adjunctive medication use underscores the need for more personalized medication recommendations in clinical guidelines.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a convenient dementia risk prediction tool for diabetic population: A large and longitudinal machine learning cohort study","authors":"Pei Yang ,&nbsp;Xuan Xiao ,&nbsp;Yihui Li ,&nbsp;Xu Cao ,&nbsp;Maiping Li ,&nbsp;Xinting Liu ,&nbsp;Lianggeng Gong ,&nbsp;Feng Liu ,&nbsp;Xi-jian Dai","doi":"10.1016/j.jad.2025.03.135","DOIUrl":"10.1016/j.jad.2025.03.135","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus has been shown to increase the risk of dementia, with diabetic patients demonstrating twice the dementia incidence rate of non-diabetic populations. We aimed to develop and validate a novel machine learning-based dementia risk prediction tool specifically tailored for diabetic population.</div></div><div><h3>Methods</h3><div>Using a prospective from 42,881 diabetic individuals in the UK Biobank, a rigorous multi-stage selection framework was implemented to optimize feature-outcome associations from 190 variables, and 32 predictors were final retained. Subsequently, eight data analysis strategies were used to develop and validate the dementia risk prediction model. Model performance was assessed using area under the curve (AUC) metrics.</div></div><div><h3>Results</h3><div>During a median follow-up of 9.60 years, 1337 incident dementia cases were identified among diabetic population. The Adaboost classifier demonstrated robust performance across different predictor sets: full model with 32 predictors versus streamlined simplified model with 13 predictors selected through forward feature subset selection algorithm (AUC: 0.805 ± 0.005 vs. 0.801 ± 0.005; <em>p</em> = 0.200) in model development employing an 8:2 data split (5-fold cross-validation for training). To facilitate community generalization and clinical applicability, the simplified model, named DRP-Diabetes, was deployed to a visual interactive web application for individualized dementia risk assessment.</div></div><div><h3>Limitations</h3><div>Some variables were based on self-reported.</div></div><div><h3>Conclusions</h3><div>A convenient and reliable dementia risk prediction tool was developed and validated for diabetic population, which could help individuals identify their potential risk profile and provide guidance on precise and timely actions to promote dementia delay or prevention.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 298-307"},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In search for affect in painful touch","authors":"Gianluca Cruciani ,&nbsp;Pietro Zingaretti ,&nbsp;Sergio De Filippis ,&nbsp;Ludovica Zanini ,&nbsp;Marco Iosa ,&nbsp;Vittorio Lingiardi ,&nbsp;Grazia Fernanda Spitoni","doi":"10.1016/j.jad.2025.03.098","DOIUrl":"10.1016/j.jad.2025.03.098","url":null,"abstract":"<div><div>Borderline Personality Disorder (BPD) is often linked to self-injurious behaviors, with many patients experiencing decreased pain sensitivity or analgesia during these episodes. In this work, we have shifted the theoretical standpoint from observing pain to observing tactile pleasure in BPD. Anchoring three linked experiments within the theoretical framework of the Affective Touch and the Social Touch Hypothesis, we studied a group of 28 BPD patients and 28 matched healthy controls. In Experiment 1, subjective pleasantness of CT-optimal tactile stimulations using various textured objects was tested. Results indicated that BPD patients rated rough and painful objects as more pleasant than controls. Experiment 2 examined self-administered touch, revealing that BPD patients preferred rough objects and used significantly greater force (triple) to achieve a pleasant sensation compared to controls, although both groups applied similar CT-optimal velocities. In experiment 3, we analyzed group performances when participants were asked to stimulate others' forearms in a pleasant manner as perceived by the receiver; no group differences in applied force or velocity were found. Overall, our findings suggest that in BPD patients, the perception of tactile pleasure involves the use of painful objects and the application of intense pressure on the skin; however, these features are not used when the patient needs to pleasantly stimulate others.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 375-383"},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring artificial intelligence (AI) Chatbot usage behaviors and their association with mental health outcomes in Chinese university students","authors":"Xing Zhang ,&nbsp;Zhaoqian Li ,&nbsp;Mingyang Zhang ,&nbsp;Mingyue Yin ,&nbsp;Zhangyu Yang ,&nbsp;Dong Gao ,&nbsp;Hansen Li","doi":"10.1016/j.jad.2025.03.141","DOIUrl":"10.1016/j.jad.2025.03.141","url":null,"abstract":"<div><div>Technology dependence has long been a critical public health issue, especially among young people. With the development of AI chatbots, many individuals are integrating these tools into their daily lives. However, we have limited knowledge about the issues related to AI chatbot usage and dependence. Therefore, we conducted a cross-sectional survey to investigate AI chatbot usage behaviors and their association with mental health outcomes among Chinese university students. A total of 1004 students who met the inclusion criteria were included in the analysis. Our survey revealed that 45.8 % of students reported using AI chatbots in the last month, with most using them one to three days per week (78.5 %) and showing light (38.2 %) to moderate (37.6 %) dependence. University students who use AI chatbots exhibited significantly higher levels of depression (<em>p</em> &lt; 0.01) and a greater proportion scoring in the moderate to high levels of depression compared to non-users (<em>p</em> &lt; 0.01). Among these users, depression was directly associated with higher AI chatbot usage and dependence (β = 0.14 to 0.20, <em>p</em> &lt; 0.05). However, no direct association was found between AI chatbot-related behaviors and mental well-being or resilience (<em>p</em> &gt; 0.05). Nevertheless, resilience may be indirectly linked to AI chatbot usage/dependence via depression (β = −0.077 to −0.052; <em>p</em> &lt; 0.05). In conclusion, AI chatbot usage is relatively common among university students, though overuse and severe dependence are infrequent. AI chatbot usage and dependence are associated with higher levels of depression; however, the causal relationship warrants further investigation.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 394-400"},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary intake of flavonoids and perimenopausal depression, and the mediating role of high-density lipoprotein cholesterol: Evidence from NHANES 2005-2018","authors":"Yali Hou,&nbsp;Siqi Li,&nbsp;Jing Wang,&nbsp;Jiaohua Dai,&nbsp;Jian Li,&nbsp;He Lv,&nbsp;Xiujuan Zhao","doi":"10.1016/j.jad.2025.03.137","DOIUrl":"10.1016/j.jad.2025.03.137","url":null,"abstract":"<div><h3>Background</h3><div>Perimenopausal depression seriously harms women's physical and mental health, and there is currently no safe and effective prevention and treatment method. Flavonoids not only have antidepressant effects, but can also promote the synthesis and utilization of high-density lipoprotein cholesterol (HDL-c), which are closely associated with depression. This study aimed to explore the association between flavonoid intake and the risk of perimenopausal depression and the mediating role of HDL-c.</div></div><div><h3>Methods</h3><div>The data of this study were collected from the US National Health and Nutrition Examination Survey (NHANES) continuously from 2005 to 2018, and flavonoid intakes data were extracted from the Food and Nutrient Database for Dietary Studies. Multivariate logistic regression was used to estimate the association between flavonoid intake and the risk of perimenopausal depression, and the mediating effect model was constructed to explore the impact of HDL-c on the correlation.</div></div><div><h3>Results</h3><div>Total 4603 perimenopausal female participants were included in this study, results showed that flavonoid intake was inversely associated with the risk of perimenopausal depression, and positively associated with serum HDL-c levels. These associations persisted after adjustment for relevant covariates. Serum HDL-c mediated the association between flavonoid intake and the risk of perimenopausal depression.</div></div><div><h3>Limitations</h3><div>As a cross-sectional study, which cannot determine the causal relationship between flavonoid intake and perimenopausal depression.</div></div><div><h3>Conclusion</h3><div>Our research showed that flavonoid intake, perimenopausal depression, and serum HDL-c are pairwise correlated, revealing that higher flavonoid intake was associated with a lower risk of perimenopausal depression, which may be mediated in part by serum HDL-c.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 243-255"},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response association between the intake of various subtypes of polyunsaturated fatty acids and depression","authors":"Feipeng Qiu ,&nbsp;Sizi Mai ,&nbsp;Jiahuan Li ,&nbsp;Yue Cao ,&nbsp;Weixing Wen ,&nbsp;Lingxiao Li ,&nbsp;Xiaohui Huang ,&nbsp;Yuli Huang","doi":"10.1016/j.jad.2025.03.140","DOIUrl":"10.1016/j.jad.2025.03.140","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a major global mental health issue. Previous studies have suggested an association between the intake of polyunsaturated fatty acids (PUFAs) and depression, but the conclusions remain controversial. Additionally, there is limited research on the relationship between the intake of specific fatty acid subtypes, such as linoleic acid (LA), arachidonic acid (AA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and Docosapentaenoic acid (DPA), and depression.</div></div><div><h3>Objective</h3><div>The relationship between different types of PUFAs and depression risks remains unclear. This study aimed to investigate how the intake of various subtypes of n-3 and n-6 PUFAs correlates with depression.</div></div><div><h3>Methods</h3><div>Participants from the National Health and Nutrition Examination Survey (NHANES) database, spanning from 2005 to 2018, were categorized into two groups: those with depression and those without, based on Patient Health Questionnaire-9 scores. The average daily intake of each PUFAs subtype was assessed through two 24-h dietary recall interviews, propensity score matching was employed to address baseline disparities, and multivariate logistic regression analysis to identify independent markers.</div></div><div><h3>Results</h3><div>The study included 18,798 participants, of whom 1287 were classified as having depression. Post-propensity score matching, multivariate logistic regression analysis revealed an inverse correlation between the intake of AA, ALA, EPA, and DHA and the risk of depression. Restricted cubic spline analysis demonstrated a linear inverse relationship between AA, ALA and EPA intake and depression. Conversely, DHA intake exhibited a nonlinear relationship with depression. No significant association was found between LA or DPA intake and depression risk.</div></div><div><h3>Conclusion</h3><div>Different types of PUFAs appear to influence depression risks differently in adults, with increased intake, AA, ALA, EPA and DHA providing a protective effect against depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 505-514"},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased serum total bile acid level is associated with improved prognosis of ischemic stroke","authors":"Yi Liu ,&nbsp;Xueyu Mao ,&nbsp;Qian Li ,&nbsp;Yang Liu ,&nbsp;Xuechun Wu ,&nbsp;Min Chu ,&nbsp;Huicong Niu ,&nbsp;Lulu Sun ,&nbsp;Yu He ,&nbsp;Xinyue Chang ,&nbsp;Daoxia Guo ,&nbsp;Mengyao Shi ,&nbsp;Yonghong Zhang ,&nbsp;Jing Zhao ,&nbsp;Zhengbao Zhu","doi":"10.1016/j.jad.2025.03.132","DOIUrl":"10.1016/j.jad.2025.03.132","url":null,"abstract":"<div><h3>Purpose</h3><div>Bile acids are implicated in the cholesterol synthesis and lipid metabolism. We aimed to prospectively investigate the relationships between serum TBA and adverse clinical outcomes after ischemic stroke.</div></div><div><h3>Methods</h3><div>Serum TBA levels at baseline were measured for 6609 ischemic stroke patients admitted at Minhang Hospital from January 2018 to December 2022. The primary outcome was a composite outcome of death and major disability (modified Rankin Scale [mRS] score, 3–6) at 3 months after stroke onset, and secondary outcomes included major disability (mRS score, 3–5), death (mRS score, 6), and ordered 7-level categorical score of the mRS.</div></div><div><h3>Results</h3><div>During the 3-month follow-up period, a total of 2118 (34.5 %) patients experienced primary outcome. After multivariate adjustment, the odds ratios of primary outcome for the highest versus the lowest quartile of TBA were 0.71 (95 % CI, 0.58–0.88; <em>P</em>_trend = 0.001). Each SD increase of log-transformed TBA was associated with a 12 % (95 % CI, 5 %–18 %) decreased risk of the primary outcome. Multiple-adjusted spline regression model showed a linear association of serum TBA levels with the primary outcome (<em>P</em> for linearity = 0.005). Subgroup analyses further confirmed the inverse associations between serum TBA levels and the prognosis of ischemic stroke.</div></div><div><h3>Conclusions</h3><div>Elevated serum TBA levels were independently associated with a decreased risk of adverse outcomes at 3 months after ischemic stroke, indicating that TBA might be implicated in the development of ischemic stroke and might be a prognostic biomarker for ischemic stroke.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 340-346"},"PeriodicalIF":4.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}