Journal of affective disorders最新文献

{"title":"Covarying gray and white matter networks characterize schizophrenia and bipolar disorders on a continuum: A data fusion machine learning approach and a brain network analysis","authors":"Alessandro Grecucci ,&nbsp;Alessandro Scarano ,&nbsp;Francesco Bruno ,&nbsp;Gerardo Salvato ,&nbsp;Xiaoping Yi ,&nbsp;Massimo Stella","doi":"10.1016/j.jad.2025.119708","DOIUrl":"10.1016/j.jad.2025.119708","url":null,"abstract":"<div><div>Schizophrenia (SZ) and Bipolar disorder (BD) share genetic and cerebral abnormalities, supporting an expanded continuum hypothesis. In this paper, we aim to better characterize differences and commonalities of gray and white matter features between SZ and BD to clarify how they align or diverge on this continuum. We transposed independent vector analysis (tIVA), a data fusion technique, to the gray and white matter images of 128 individuals diagnosed with SZ, 128 with BD and 127 healthy controls (CTRL), matched for gender, age and IQ. Of the 18 tIVA networks detected, three differed between SZ and BD (tIV9,14,15), primarily involving fronto-temporal regions. These same networks plus two more (tIV3,4), differed between SZ and CTRL indicating a larger compromission, whereas only one network (tIV9) differed between BD and controls. Overall, SZ displayed the more pronounced GM-WM abnormalities in both extent and severity with BD lying in an intermediate position. Of note, one network differed among all three groups (SZ, BD, and CTRL). Random forest classification confirmed these results by indicating the tIV9 as the main predictors that separate the three groups. Moreover, to appreciate eventual differences between networks across the three groups a network analyses was performed. Individuals with SZ demonstrated a significantly different clustering coefficient and density compared to CTRL. While the comparison between individuals with BD and controls did not show marked differences. This study sheds new lights on the expanded continuum hypothesis according to which individuals with schizophrenia and bipolar disorder lay on the same continuum of neurological abnormalities.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119708"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder","authors":"Łukasz Zadka ,&nbsp;Benjamin Eggerstorfer ,&nbsp;Igor Buzalewicz ,&nbsp;Chrysoula Vraka ,&nbsp;Agnieszka Rusak ,&nbsp;Godber M. Godbersen ,&nbsp;Agnieszka Opalińska ,&nbsp;Jakob Unterholzner ,&nbsp;Agnieszka Ulatowska-Jarża ,&nbsp;Cecile Philippe ,&nbsp;Katarzyna Haczkiewicz-Leśniak ,&nbsp;Leo R. Silberbauer ,&nbsp;Matej Murgaš ,&nbsp;Lukas Nics ,&nbsp;Andreas Hahn ,&nbsp;Marcus Hacker ,&nbsp;Agnieszka Gomułkiewicz ,&nbsp;Dan Rujescu ,&nbsp;Marzenna Podhorska-Okołów ,&nbsp;Rupert Lanzenberger ,&nbsp;Gregor Gryglewski","doi":"10.1016/j.jad.2025.119740","DOIUrl":"10.1016/j.jad.2025.119740","url":null,"abstract":"<div><div>With their ability to cross the blood-brain barrier, transport and regulate the release of various signaling molecules, extracellular vesicles (EVs) constitute a novel avenue to study intercellular communication in various pathologies, including psychiatric disorders. We studied 34 major depressive disorder (MDD) patients and 57 healthy controls and characterized EVs isolated from plasma using digital holographic tomography (DHT) and nanoparticle tracking analysis (NTA). EVs detected in DHT were markedly smaller and less variable in size in MDD patients. Furthermore, a lower variance of refractive indices related to the dry mass density of EVs was observed in patients. Meanwhile, NTA revealed a trend for elevated concentration of EVs in MDD. In DHT, EV dimensions correlated with plasma mRNA expression of exosomal markers <em>CD63</em> and <em>CD9</em>, with corresponding alterations in MDD. Levels of EV concentration and <em>CD9</em> were both negatively correlated with antidepressant treatment response. Utilizing electron microscopy and immunoblots we confirmed the presence of serotonin transporters (SERT) as EV cargo. SERT levels in EVs correlated with cerebral SERT binding potential in the amygdala measured using positron emission tomography. Next to the implication of altered EV communication in mood disorders, the pronounced differences in plasma EV characteristics and exosomal markers in MDD might inform the development of assays with diagnostic or prognostic value for clinical practice.</div></div><div><h3>ClinicalTrials.gov</h3><div>Patient Stratification and Treatment Response Prediction in Neuropharmacotherapy Using Hybrid Positron Emmission Tomography/Magnetic Resconance Imaging (PET/MR); https://clinicaltrials.gov/study/NCT02711215; NCT02711215.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119740"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of delivery format on the effectiveness and acceptability of self-guided interventions for depression in older adults: A systematic review and meta-analysis.","authors":"Dara Kiu Yi Leung, Dipsy Ho Sum Wong, Frankie Ho Chun Wong, Stephanie Ming Yin Wong, Oscar Long Hung Chan, Gloria Hoi Yan Wong, Wai Chi Chan, Terry Yat Sang Lum","doi":"10.1016/j.jad.2025.119756","DOIUrl":"10.1016/j.jad.2025.119756","url":null,"abstract":"<p><p>Self-guided interventions could improve the availability of evidence-based psychotherapies for late-life depressive symptoms. However, their treatment outcomes and acceptability across delivery formats remain uncertain. This review aimed to examine the effectiveness and acceptability of self-guided intervention for older adults with depressive symptoms and the impact of different intervention features. Randomised controlled trials included older adults (mean age ≥ 60 years) with elevated depressive symptoms who received self-guided interventions for depression were eligible. Trials were extracted from an existing database and updated systematic literature searches in PubMed, PsychINFO, Embase, and Cochrane Library (last update: 20th Mar 2025). Data were synthesised with random-effects meta-analysis, subgroup analysis, and meta-regressions. Outcomes included depressive symptoms, quality of life, and dropout rates. Seven studies with 1170 participants were identified. Compared to controls, self-guided interventions had small-to-moderate effect in reducing depressive symptoms at post-treatment (g = 0.46, 95 % CI 0.20 to 0.73), but the effect was not sustained at 3-to-12-month follow-up (g = 0.15, 95 % CI -0.45 to 0.74). Effects on quality of life remains inconclusive. Acceptability was comparable between self-guided interventions and control conditions (RR = 1.52, p = .294). No differences in treatment effects and acceptability were observed across delivery formats, support levels, or initial human screening. Most studies showed a moderate-to-high risk of bias (n = 6). Self-guided interventions for depression were associated with reductions in depressive symptoms and were acceptable to older adults, regardless of delivery format and level of human support. They may be considered a brief intervention option in resource-limited setting.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119756"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The moderating role of sexual identity centrality in the association between gay community stress and social anxiety among sexual minority men","authors":"Zachary A. Soulliard ,&nbsp;Anthony J. Maiolatesi ,&nbsp;Robert B. Manning III ,&nbsp;Katie Wang ,&nbsp;John E. Pachankis","doi":"10.1016/j.jad.2025.119755","DOIUrl":"10.1016/j.jad.2025.119755","url":null,"abstract":"<div><div>Gay community stress has been linked to social anxiety among sexual minority men; however, the moderating role of identity-related processes (e.g., sexual identity centrality) has yet to be examined in this association. The present study investigated the association between gay community stress and two measures of social anxiety (i.e., self-reported social anxiety symptoms and interviewer-based diagnostic assessment of social anxiety disorder), as well as the moderating role of sexual identity centrality. Data come from the baseline assessment of a randomized controlled trial testing an LGBTQ-affirmative cognitive behavioral therapy intervention with 251 sexual minority men between the ages of 18–35. Results showed that gay community stress was significantly associated with social anxiety symptoms and social anxiety disorder diagnosis. Sexual identity centrality moderated these associations, such that the link between gay community stress and both social anxiety assessments was stronger among participants with higher levels of sexual identity centrality. These significant findings remained even after accounting for sexual orientation-based discrimination and general life stress. Future research can investigate how the interaction between gay community stress, sexual identity centrality, and social anxiety develops over time to inform interventions aimed at mitigating social distress among sexual minority men.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119755"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does intimate partner violence mediate the association between adverse childhood experiences and internalizing symptomatology in women? A mediation meta-analysis.","authors":"Julia Martini, Audrey-Ann Deneault, Jenney Zhu, Nicole Racine, Pasco Fearon, Sheri Madigan, Jennifer Jenkins","doi":"10.1016/j.jad.2025.119742","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119742","url":null,"abstract":"<p><p>Research is needed to elucidate the underlying mechanisms that link adverse childhood experiences (ACEs) and internalizing symptomatology in women. In the present study, we conducted a systematic review to assess whether intimate partner violence (IPV) mediated the association between ACEs and internalizing symptomatology in women. We utilized a novel statistical technique-meta-analytic structural equation modelling (MASEM)-to examine the path model by amalgamating effect sizes across all studies, thereby combining both meta-analytic and structural equation modelling approaches. A total of 25 studies (N = 30,737 women) were included in the MASEM. The average age of female participants was 30.7 years. Results indicated that IPV partially mediated the association between ACEs and internalizing symptomatology, explaining 16 % of the total effect. Tested moderators included sociodemographic factors (age, SES, single status, and minority status) and methodological factors, including IPV characteristics (IPV category and IPV timeline), psychopathology assessment method, and the number of ACEs items measured. None of the tested moderators significantly influenced the indirect pathway. Findings suggest that IPV is an important risk factor in explaining why ACEs are associated with internalizing symptomatology in women.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119742"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of neighborhood environment on adolescent anxiety and depression: A moderated mediation model involving screen time and family function","authors":"Qian-Wen Xie ,&nbsp;Xu Li Fan ,&nbsp;Yuan Sun ,&nbsp;Yawen Xuan ,&nbsp;Jingjing Lu ,&nbsp;Xudong Zhou","doi":"10.1016/j.jad.2025.119751","DOIUrl":"10.1016/j.jad.2025.119751","url":null,"abstract":"<div><h3>Objective</h3><div>While the relationship between neighborhood environment and adolescent mental health is well-documented, few studies have examined the roles of screen time and family function in this association. This study aims to explore the “environment-behavior-health” pathway by investigating how neighborhood environment, screen time, and family function jointly influence adolescent anxiety and depression.</div></div><div><h3>Method</h3><div>Data were drawn from a large-scale, two-wave survey of 5th–12th grade Chinese adolescents. A moderated mediation model was constructed to examine whether screen time mediates the relationship between neighborhood environment and adolescent anxiety and depression, and whether this indirect effect is moderated by family function.</div></div><div><h3>Results</h3><div>The final sample included 8961 Chinese adolescents. Neighborhood environment was negatively associated with adolescents' screen time (b = −0.513, <em>p</em> &lt; 0.001), anxiety (b = −0.984, p &lt; 0.001) and depression (b = −1.357, p &lt; 0.001). Screen time partially mediated the effects of neighborhood environment on anxiety (b = −0.048, 95 % CI [−0.075, −0.025]) and depression (b = −0.068, 95 % CI [−0.102, −0.039]). Moreover, family function significantly moderated the association of neighborhood environment with anxiety (b = −0.441, <em>p</em> &lt; 0.01) and depression (b = −0.401, <em>p</em> &lt; 0.05), as well as the association of screen time with anxiety (b = −0.055, p &lt; 0.01) and depression (b = −0.051, p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>These findings extend the “environment-behavior-health” framework and highlight the need for multi-level strategies to support adolescent mental health.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119751"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidities and emotions - unpacking the sentiments of pediatric patients with multiple long-term conditions through social media feedback: A large language model-driven study","authors":"Temidayo I. Oluwalade ,&nbsp;Hossein Ahmadi ,&nbsp;Lin Huo ,&nbsp;Richard Sharpe ,&nbsp;Shang-Ming Zhou","doi":"10.1016/j.jad.2025.119752","DOIUrl":"10.1016/j.jad.2025.119752","url":null,"abstract":"<div><h3>Objectives</h3><div>The emotional and psychological challenges faced by children with multiple long-term conditions (MLTCs) remain underexplored. This study aimed to analyze sentiments and emotions expressed by this vulnerable population and their caregivers on social media, assess the effects of comorbidities and the COVID-19 pandemic on emotional well-being.</div></div><div><h3>Methods</h3><div>Narratives from the Care Opinion platform (2008–2023) were analyzed by a model called CoEmoBERT, developed using the large language model, distilroberta-base transformer model. The CoEmoBERT-based sentiment analysis categorized emotions into “Positive”, “Negative”, and “Neutral,” with further refinements into specific emotions such as “Sad,” “Fear”, “Satisfied” etc. through pretraining and transferring process. Comorbidity associations with emotions were analyzed. We further examined the impact of the COVID-19 pandemic on patient sentiments and investigated temporal trends in emotional expressions.</div></div><div><h3>Results</h3><div>Of 389 narratives, 93.8 % reflected negative sentiments, with “Sad” (60.9 %) and “Fear” (15.4 %) being the most prevalent. Negative emotions were linked to severe comorbidities like asthma, cancer, and chronic pain, highlighting the emotional burden of managing MLTCs. Positive sentiments (5.9 %) were associated with effective communication and exceptional healthcare experiences. The analysis revealed strong associations between certain comorbidity combinations and specific emotional responses, with mental health conditions showing the most diverse range of comorbidities and emotional impacts. The COVID-19 pandemic exacerbated negative sentiments, particularly sadness and disgust.</div></div><div><h3>Conclusion</h3><div>This study underscores the significant emotional burden on children with MLTCs, emphasizing the need for integrated care approaches to both physical and emotional well-being. These findings can guide the development of patient-centered care for this population.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119752"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food insecurity is associated with depressive and anxiety symptoms among caregivers of young children in arid and semi-arid regions of Kenya: A cross-sectional study","authors":"Esther Jebor Chongwo ,&nbsp;Anja C. Huizink ,&nbsp;Daisy Chelangat ,&nbsp;Eunice Njoroge ,&nbsp;Barack Aoko ,&nbsp;Martha Kaniala ,&nbsp;Moses Esala ,&nbsp;Phillis Magoma ,&nbsp;Joyce Marangu ,&nbsp;Margaret Kabue ,&nbsp;Daniel Rabok ,&nbsp;Susan Nyamanya ,&nbsp;Anil Khamis ,&nbsp;John Ng'asike ,&nbsp;Abubakar Baasba ,&nbsp;Siad Guyo ,&nbsp;Amina Abubakar","doi":"10.1016/j.jad.2025.119754","DOIUrl":"10.1016/j.jad.2025.119754","url":null,"abstract":"<div><h3>Introduction</h3><div>This study fills a critical gap by assessing the prevalence and association between food insecurity and depressive and anxiety symptoms among caregivers of young children in Kenya's arid and semi-arid lands (ASALs).</div></div><div><h3>Methods</h3><div>A cross-sectional design was used to collect data from caregivers of children aged 0–3 years from Lamu, Isiolo and Turkana Counties (<em>N</em> = 446). Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 scales were used to assess depressive and anxiety symptoms, respectively. We also administered the Household Food Insecurity Access Scale, alongside sociodemographic and health-related questionnaires.</div></div><div><h3>Results</h3><div>The mean caregiver age was 29.37 years (SD = 6.56). Majority of participants (73.09 %) lacked improved sanitation, and 33.86 % had their first pregnancy before age 18. High levels of depressive (22.4 %) and anxiety symptoms (11.2 %) were observed. Food insecurity was significantly associated with both depressive (β = 0.24, 95 % CI [0.18 to 0.30], <em>p</em> &lt; 0.001) and anxiety (β = 0.15, 95 % CI [0.10 to 0.21], p &lt; 0.001) symptoms. Increased maternal age, higher education, and having a child with chronic illness were significant risk factors for depressive and anxiety symptoms.</div></div><div><h3>Conclusion</h3><div>Depressive and anxiety symptoms are highly prevalent among caregivers in Kenya's ASAL and are significantly associated with food insecurity. These findings underscore the need for integrating mental health screening and support into maternal and child health programs and addressing food insecurity through multi-sectoral interventions. Further research is needed to explore the nexus between food insecurity, mental health, and other contextual factors influencing caregivers and child well-being in ASAL regions.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119754"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying potential pathogenic oxidative stress-related genes in depression through multi-omics summary-data-based Mendelian randomization analysis","authors":"Junxiang Cheng ,&nbsp;Zhifen Liu ,&nbsp;Ruifang Zhu ,&nbsp;Qia Liu ,&nbsp;Hong Han ,&nbsp;Na Liu ,&nbsp;Juan Shi ,&nbsp;Shifan Han ,&nbsp;Ning Ma","doi":"10.1016/j.jad.2025.119734","DOIUrl":"10.1016/j.jad.2025.119734","url":null,"abstract":"<div><h3>Purpose</h3><div>The relationship between oxidative stress-related genes (OSGs) and depression remains unclear. This study investigates causal associations between OSGs and depression susceptibility to elucidate their roles in this mental health condition.</div></div><div><h3>Methods</h3><div>This study employed a Summary-data-based Mendelian randomization (SMR) approach to investigate the associations between oxidative stress-related genes (OSGs) and depression risk. Differentially expressed genes (DEGs) associated with depression were identified from merged Gene Expression Omnibus transcriptome data and intersected with OSGs from GeneCards to define depression-related OSGs (DeOSGs). SMR analyses using methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein quantitative trait loci (pQTL) data from large-scale consortia and cohorts evaluated associations between DeOSG methylation, expression, and protein levels with depression risk. Colocalization analysis identified shared causal variants between traits. Functional enrichment and validation using FinnGen cohorts further supported findings.</div></div><div><h3>Results</h3><div>We identified 488 DeOSGs in depression patients. SMR analyses across mQTL, eQTL, and pQTL levels identified 130 methylation sites, 28 genes, and three proteins linked to depression risk. Ten CpG sites and three DeOSGs showed strong colocalization evidence. Integrative analysis identified four genes (<em>BRAF, CUTA, SLC27A3,</em> and <em>SMARCA4</em>) as potential candidates influencing depression risk through methylation and expression changes. External validation in the FinnGen cohort confirmed a negative association for <em>CUTA</em> expression in blood eQTL data.</div></div><div><h3>Conclusions</h3><div>This study identified <em>BRAF, CUTA, SLC27A3,</em> and <em>SMARCA4</em> as influencing depression risk through methylation and expression changes. These findings provide potential targets for future therapeutic exploration and biomarker development.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119734"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mood stabilizers: Insights from users' perceptions","authors":"M.F. Tagni ,&nbsp;S.A. Strejilevich ,&nbsp;S. Camino ,&nbsp;E. Carballo ,&nbsp;M. Guglielmetti ,&nbsp;L. López Escalona ,&nbsp;M. Oppel ,&nbsp;L. Sabattini ,&nbsp;A. Szmulewicz","doi":"10.1016/j.jad.2025.119753","DOIUrl":"10.1016/j.jad.2025.119753","url":null,"abstract":"<div><h3>Background</h3><div>Opinions and subjective perceptions regarding psychopharmacological treatment have proven to be strong predictors of quality of life, adherence, and general outcomes, as well as a rich source of data for research. Although mood stabilizing agents (MSA) represent the cornerstone of the treatment of bipolar disorders (BDs), data on the experiences of patients undergoing treatment with these drugs are scarce. We aimed to explore and compare user-reported data on four first-line MSA and identify predictors of treatment satisfaction.</div></div><div><h3>Methods</h3><div>We conducted a quantitative analysis of a random sample of 200 posts specifically related to first-line mood stabilizers (lithium, lamotrigine, valproate, and quetiapine) from individuals undergoing long-term treatment for BDs. Demographical, clinical, somatic, and emotional/psychological side-effects and treatment-related data were analyzed.</div></div><div><h3>Results</h3><div>This study found that the reported levels of satisfaction with MSAs were notably high. Lamotrigine received higher satisfaction ratings than quetiapine and valproate, after including age, sex, dose, and length of treatment in the models. Lithium was rated higher than valproate and quetiapine, although this difference did not reach statistical significance. Obsessive-compulsive symptoms, emotional hyperreactivity, cognitive symptoms, anxiety, weight gain, and gastrointestinal symptoms emerged as significant predictors of treatment dissatisfaction.</div></div><div><h3>Conclusions</h3><div>The findings of this study underscore the significant role that emotional and psychological side effects play in treatment dissatisfaction during MSA use. Both research and clinical decisions should consider the subjective experiences of patients undergoing MSA treatment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119753"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}