Journal of affective disorders最新文献

{"title":"Letter to the editor: Associations of dietary habits, inflammatory dietary index, and lifestyle factors with depressive symptoms: A cross-sectional study of 53,539 individuals with thyroid nodules.","authors":"Haoyuan Luo, Zexu Tang, Ru Liu, Jinwen Fang, Kai Lu","doi":"10.1016/j.jad.2025.120062","DOIUrl":"10.1016/j.jad.2025.120062","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120062"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Efficacy of digital mental health interventions for PTSD symptoms: A systematic review of meta-analyses\".","authors":"Ali Fakhrudin, Rikas Saputra, Erfan Ramadhani, Kadek Suhardita, Apriyadi Sofyan, Sisca Folastri","doi":"10.1016/j.jad.2025.120052","DOIUrl":"10.1016/j.jad.2025.120052","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120052"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical reflections on the association between diet quality and depression risk: Methodological considerations arising from Molero et al. (2025).","authors":"Wenjia Li, Yuhan Zhu, Wenjun Li","doi":"10.1016/j.jad.2025.120059","DOIUrl":"10.1016/j.jad.2025.120059","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120059"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent depressive-symptom trajectories predict conversion from mild cognitive impairment to Alzheimer's disease: A longitudinal ADNI study.","authors":"Xiahao Ding, Zhiying Zheng, Haitong Wang, Yuanzhen Shao, Shouqiang Zhu, Zhengliang Ma, Xiaoping Gu, Tianjiao Xia","doi":"10.1016/j.jad.2025.120066","DOIUrl":"10.1016/j.jad.2025.120066","url":null,"abstract":"<p><strong>Background: </strong>Depressive symptoms are increasingly recognized as a modifiable risk factor for Alzheimer's disease (AD). However, most studies have assessed these symptoms at a single time point or within overlapping symptom-outcome windows, limiting temporal inference.</p><p><strong>Methods: </strong>We analyzed 397 participants with baseline mild cognitive impairment (MCI) from the Alzheimer's Disease Neuroimaging Initiative. Depressive symptoms were measured with the 15-item Geriatric Depression Scale (GDS). Group-based trajectory modeling classified symptom courses over the first 36 months. Cox proportional-hazards models estimated the risk of MCI-to-AD conversion over a maximum follow-up of 156 months after the landmark. Restricted cubic spline analysis evaluated the dose-response relationship between 36-month GDS scores and conversion hazard.</p><p><strong>Results: </strong>Three distinct trajectories emerged: persistently low, moderate, and high depressive symptoms. Compared with the low-symptom group, the moderate-symptom group had an adjusted hazard ratio (HR) of 2.36 (95 % CI 1.35-4.13; p = 0.003), and the high-symptom group an HR of 3.79 (95 % CI 1.86-7.69; p < 0.001). A two-group split (low vs. high) produced an adjusted HR of 1.98 (95 % CI 1.25-3.13; p = 0.003). Spline analysis confirmed a linear, dose-response association: each one-point increase in 36-month GDS corresponded to a proportional rise in hazard (p < 0.001).</p><p><strong>Limitations: </strong>The GDS is self-reported and not a clinical diagnosis.</p><p><strong>Conclusions: </strong>Persistently high depressive symptoms over 36 months after MCI diagnosis provide robust prognostic information for AD progression. Routine monitoring and targeted interventions to reduce sustained depressive burden may help delay conversion from MCI to AD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120066"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG microstates as indicators and predictors of response through 4 weeks of treatment in adolescents with major depressive disorder.","authors":"Yaru Zhang, Tingyu Yang, Xilong Cui, Chunxiang Huang, Guangrong Xie, Xuerong Luo, Yuqiong He","doi":"10.1016/j.jad.2025.119511","DOIUrl":"10.1016/j.jad.2025.119511","url":null,"abstract":"<p><strong>Objectives: </strong>This study sought to identify alterations in electroencephalography (EEG) microstates among adolescents with first-episode and drug-naive major depressive disorder (MDD). Additionally, it aimed to explore the association of EEG microstates with clinical characteristics and patient response to antidepressant treatment over a period of 4 weeks.</p><p><strong>Methods: </strong>A total of 81 first-episode and drug-naive adolescents with MDD and 60 healthy controls (HCs) were recruited. General demographic information and resting EEG data were collected from all participants. Depression symptoms were evaluated using the Hamilton Depression Scale (HAMD) at baseline and following 4 weeks of antidepressant treatment. The study employed EEG microstates and support vector machine (SVM) techniques for data interpretation.</p><p><strong>Results: </strong>Adolescents with first-episode and drug-naive MDD exhibited a significant reduction in the duration of microstate D and an increase in the occurrence of microstate A compared to the HCs (p < 0.05).When comparing treatment responders and non-responders, treatment responders demonstrated an elevated occurrence and coverage of microstate A and transition probabilities of A-C. Conversely, treatment responders showed decreased occurrence and coverage of microstate B and transition probabilities of BD (all p < 0.05). Upon feature selection, five distinct micro-state parameters were utilized as features. Subsequently, the SVM model demonstrated its capability to distinguish between treatment responders and non-responders, achieving an average accuracy of 75.29 %. Notably, the model's peak performance was characterized by a classification accuracy of 82.35%, accompanied by an AUC of 0.819, a sensitivity of 75.00%, and a specificity of 88.89%.</p><p><strong>Conclusions: </strong>Microstate A may be associated with the severity of depressive symptoms, while microstate B might serve as a potent predictor of antidepressant response in adolescents with first-episode and drug-naive MDD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119511"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Metformin treatment improves depressive symptoms associated with type 2 diabetes: A 24-week longitudinal study\".","authors":"Jiayang Dong, Xinyue Yang, Wenjuan Zhang","doi":"10.1016/j.jad.2025.120054","DOIUrl":"10.1016/j.jad.2025.120054","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120054"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linguistic predictors of response to internet-based written CBT for PTSD symptoms of 9/11 world trade center recovery workers and survivors.","authors":"Tomasina Leska, Zoe Schreiber, Eden Astorino, Maya Verghese, John C Markowitz, Saren Seeley, Hannah Brinkman, Mary Kowalchyk, Leah Cahn, Cindy J Aaronson, Maria Boettche, Christine Knaevelsrud, Robert H Pietrzak, Adriana Feder","doi":"10.1016/j.jad.2025.119828","DOIUrl":"10.1016/j.jad.2025.119828","url":null,"abstract":"<p><p>Trauma-focused cognitive-behavioral therapies (CBT) are the mainstay of posttraumatic stress disorder (PTSD) treatment, but treatment response is heterogeneous. We used automated linguistic analysis to identify markers of PTSD symptom improvement in response to integrative testimonial therapy (ITT), an internet-based, therapist-assisted written CBT for PTSD, for 9/11 World Trade Center rescue and recovery workers and survivors with PTSD symptoms. Therapy comprised 11 written narratives, separated into biographical reconstruction, exposure, and cognitive reappraisal narrative modules. Narrative data of 35 ITT completers in a larger clinical trial were analyzed using the Linguistic Inquiry and Word Count (LIWC) software and the Valence Aware Dictionary and sEntiment Reasoner (VADER) toolkit. Separate regression analyses were conducted to predict treatment response, assessed with the PTSD Checklist for DSM-5 (PCL-5) at baseline and post-treatment. Four LIWC word categories collectively explained 59 % of the variance in PCL-5 score improvement: higher use of death, causation, and motion words in biographical narratives, and lower use of social behavior words in exposure narratives, were associated with greater improvement. Higher VADER negative sentiment score in biographical narratives was also associated with greater improvement. Findings provide insight into potential factors driving therapeutic response to written CBT for PTSD and may help advance personalized treatment for individuals with this disorder.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119828"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Childhood Experiences (ACEs) and childbearing and perinatal mental health outcomes in a clinical sample of women.","authors":"Alistair J Souch, Ian R Jones, Katherine H Shelton, Cerith S Waters","doi":"10.1016/j.jad.2025.120038","DOIUrl":"10.1016/j.jad.2025.120038","url":null,"abstract":"<p><p>Adverse Childhood Experiences (ACE) are associated with later life complications, including childbearing outcomes and episodes of mental ill-health. The perinatal period is a timepoint of vulnerability to the impacts of early life adversity, such as ACEs. We explored the association between maternal exposure to ACEs, entering parenthood, and episodes of mental ill-health during the perinatal period in a clinical sample with a mental health diagnosis to determine the increased vulnerability the perinatal period brings. Participants (N = 1494) were recruited across the UK, were aged 18 years or over, and female. Standardised self-report questionnaires ascertained demographic, parenthood, mental health, and ACE related information. Within this clinical sample, (N = 1010) women had given birth, and episodes of perinatal mental ill-health were assessed. Maternal childhood physical abuse was associated with an increased likelihood of having children, yet having divorced parents reduced this likelihood. In a clinical sub-sample of women who had children, physical abuse predicted a perinatal episode of bipolar disorder, sexual abuse a perinatal episode of anxiety disorders, and emotional neglect a perinatal episode of depressive disorders. CONCLUSIONS: Specific ACE exposure is associated with entering parenthood and episodes of mental ill-health during the perinatal period. This highlights a moment in the human lifespan when women who have experienced early adversity may be particularly vulnerable; the findings therefore have potential implications for the resourcing of specialist clinical services.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120038"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-metabolic perspective on the association of seven psychiatric disorders and five common auditory diseases: a bidirectional two-sample Mendelian randomization study and mediation analysis.","authors":"Jinyuan Yang, Yijing Chen, Guojie Dong, Ying Ma, Rongfeng Lin, Yongyi Yuan","doi":"10.1016/j.jad.2025.120044","DOIUrl":"10.1016/j.jad.2025.120044","url":null,"abstract":"<p><strong>Introduction: </strong>Although the relationship between psychiatric disorders and common auditory diseases has been discovered in observational studies, the causal linkage between them remains inconclusive.</p><p><strong>Methods: </strong>The bidirectional two-sample Mendelian randomization (MR) analysis was performed, drawing on the most recent and expansive genome-wide association studies (GWAS) data for seven psychiatric disorders and five common auditory diseases. Additionally, a mediation analysis was conducted using data on 731 immune cell phenotypes and 1400 metabolite levels to explore potential mediating factors influencing the causal pathways.</p><p><strong>Results: </strong>Autism Spectrum Disorder (ASD) could increase the risk of presbycusis (odds ratio [OR] = 1.161 [95 % confidence interval (CI), 1.042-1.295], P-value = 0.007) through CD25 on CD45RA- CD4 not regulatory T cell (Mediation effect β = 0.017), and Major Depressive Disorder (MDD) could increase the risk of vertigo (OR = 1.215 [95 % CI, 1.043-1.415], P-value = 0.012) through CD33+ HLA DR+ CD14dim Absolute Count (Mediation effect β = 0.007). Alzheimer's Disease (AD) could reduce the risk of presbycusis through four metabolite levels related to lipid metabolism. And Bipolar Disorder I (BD I) could reduce the risk of vertigo, as well as sudden sensorineural hearing loss (SSNHL) could reduce the risk of Post Traumatic Stress Disorder (PTSD).</p><p><strong>Conclusion: </strong>This study underscores the intricate causal links between psychiatric disorders and auditory diseases. Mediation analyses indicate that immune cells are facilitators of positive effects, while metabolite levels play a protective role. These insights offer potential pathways for more effective clinical diagnosis and treatment.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120044"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The link between improvement in sleep and depressed mood: Exploring the role of repetitive negative thinking and behavioural activation.","authors":"Vanika Lall, Romola S Bucks, Peter M McEvoy, Bruce N C Campbell, Laura Smith, Melissa J Ree","doi":"10.1016/j.jad.2025.120046","DOIUrl":"10.1016/j.jad.2025.120046","url":null,"abstract":"<p><p>There is extensive evidence supporting a link between poor sleep and worse depression outcomes. Moreover, improvement in sleep contributes to enhanced depression outcomes. However, processes underlying this sleep-depression link are unclear. The current study examined whether changes in potential underlying processes, namely repetitive negative thinking (RNT) and behavioural activation (BA) can explain the relationship between improvement in reported sleep disturbance (reduction in the number of days participants experience sleep difficulties) and depressed mood. Data were analysed from 127 participants (mean [SD] age 39.16 [14.81], 60.6 % women) who attended a group CBT mood management program at a government mental health service. Our study found a significant association between improvement in sleep difficulties and improvement in depressed mood, however, this relationship was no longer significant (no direct association) when controlling for improvements in RNT, ab = 0.56, CI [0.21, 1.01], and BA, ab = 1.08, CI [0.41, 1.84]. The preliminary findings suggest that reduced RNT and enhanced BA may play an important role in explaining how improvement in sleep is related to improvement in depressed mood. Future research should investigate whether early improvements in sleep contributes to subsequent improvements in depressed mood via improvements in RNT and BA. To establish temporal ordering and assess causality, future studies should collect data across multiple time points; and incorporate a more comprehensive measure of sleep.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120046"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}