Adverse Childhood Experiences (ACEs) and childbearing and perinatal mental health outcomes in a clinical sample of women.

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY
Journal of affective disorders Pub Date : 2025-12-15 Epub Date: 2025-08-06 DOI:10.1016/j.jad.2025.120038
Alistair J Souch, Ian R Jones, Katherine H Shelton, Cerith S Waters
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引用次数: 0

Abstract

Adverse Childhood Experiences (ACE) are associated with later life complications, including childbearing outcomes and episodes of mental ill-health. The perinatal period is a timepoint of vulnerability to the impacts of early life adversity, such as ACEs. We explored the association between maternal exposure to ACEs, entering parenthood, and episodes of mental ill-health during the perinatal period in a clinical sample with a mental health diagnosis to determine the increased vulnerability the perinatal period brings. Participants (N = 1494) were recruited across the UK, were aged 18 years or over, and female. Standardised self-report questionnaires ascertained demographic, parenthood, mental health, and ACE related information. Within this clinical sample, (N = 1010) women had given birth, and episodes of perinatal mental ill-health were assessed. Maternal childhood physical abuse was associated with an increased likelihood of having children, yet having divorced parents reduced this likelihood. In a clinical sub-sample of women who had children, physical abuse predicted a perinatal episode of bipolar disorder, sexual abuse a perinatal episode of anxiety disorders, and emotional neglect a perinatal episode of depressive disorders. CONCLUSIONS: Specific ACE exposure is associated with entering parenthood and episodes of mental ill-health during the perinatal period. This highlights a moment in the human lifespan when women who have experienced early adversity may be particularly vulnerable; the findings therefore have potential implications for the resourcing of specialist clinical services.

妇女临床样本中的不良童年经历与生育和围产期心理健康结果
不良童年经历(ACE)与以后的生活并发症有关,包括生育结果和精神疾病的发作。围产期是一个易受早期生活逆境(如ace)影响的时间点。我们在一个有心理健康诊断的临床样本中探讨了母亲暴露于ace、初为父母和围产期精神疾病发作之间的关系,以确定围产期带来的脆弱性增加。参与者(N = 1494)在英国各地招募,年龄在18 岁或以上,女性。标准化的自我报告问卷确定了人口统计学、亲子关系、心理健康和ACE相关信息。在这个临床样本中,(N = 1010)名妇女生育,并评估围产期精神疾病的发作情况。母亲童年时期的身体虐待与生育孩子的可能性增加有关,而父母离婚则降低了这种可能性。在有孩子的妇女的临床亚样本中,身体虐待预示着围产期双相情感障碍发作,性虐待预示着围产期焦虑症发作,情感忽视预示着围产期抑郁症发作。结论:特异性ACE暴露与初为人父母和围产期精神疾病发作有关。这突出表明,在人类生命的某个时刻,早期经历过逆境的女性可能特别脆弱;因此,研究结果对专科临床服务的资源配置有潜在的影响。
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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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