Journal of affective disorders最新文献

{"title":"Updated insight into the pathophysiology of premenstrual dysphoric disorder and therapeutic approaches.","authors":"Jerin Sultana, Ashish Ranjan Sharma, Sadia Tabassum Soha, Garima Sharma, Subrata Banik, Afroza Parvin, Md Ibrahim Khalil, Md Ashraful Hasan, Mohammad Mahfuz Ali Khan Shawan","doi":"10.1016/j.jad.2026.121593","DOIUrl":"10.1016/j.jad.2026.121593","url":null,"abstract":"<p><p>Premenstrual Dysphoric Disorder (PMDD) is a debilitating menstrual cycle-related condition that emerges during the luteal phase preceding menstruation and is characterized by pronounced mood disturbances accompanied by associated physical symptoms. PMDD involves dysregulation of hormones and neurotransmitters, influenced by genetic, psychosocial, immune, and opioid factors that contribute to symptom severity. Given the substantial impact of PMDD symptoms, including mood changes, sleep disturbances, and disordered eating, on women's daily lives, further investigation into its underlying mechanisms is essential. The investigation of genetic influences and their interplay with hormonal and neurotransmitter dynamics in PMDD remains nascent, with limited research conducted in this domain. However, several pharmacological and surgical treatment options are available for PMDD, including SSRIs, hormonal therapies, GnRH agonists, SPRMs, sepranolone (UC1010), and, in severe cases, surgical menopause. These therapies seek to mitigate symptoms by correcting hormonal and neurotransmitter abnormalities. This narrative review provides a comprehensive overview of PMDD, encompassing its pathophysiology, etiology, clinical manifestations, epidemiology, prognosis, and current therapeutic strategies.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121593"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between complete blood count-derived inflammatory markers and ADHD symptom trajectories in childhood: A prospective cohort study.","authors":"Qidi Tang, Xinyan Xie, Ping Xiong, Yuyang He, Yangyang Yang, Ruohan Tang, Bing Xiang, Hongmin Zhu","doi":"10.1016/j.jad.2026.121611","DOIUrl":"10.1016/j.jad.2026.121611","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify distinct trajectories of inattention (IA), hyperactivity-impulsivity (HI), and oppositional defiant (OD) symptoms in children with ADHD and examine their associations with complete blood count (CBC)-derived inflammatory markers.</p><p><strong>Methods: </strong>A total of 757 children aged 6-16 years with ADHD were followed for two years. ADHD symptoms were assessed using the SNAP-IV parent rating scale at baseline, 12, and 24 months. Group-based trajectory modeling (GBTM) identified distinct trajectories. Fasting venous blood was used to calculate inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII). Multivariable logistic regression examined associations between these markers and trajectories.</p><p><strong>Results: </strong>Four trajectories were identified per domain. IA: moderate-declining (58%), stable-moderate (22%), persistent-mild (15%), and persistent-severe (5%). HI: moderate-high declining (37%), stable-mild (34%), sub-clinical stable (22%), and rapidly-improving (7%). OD: asymptomatic (28.3%), high-severity declining (27.9%), stable-moderate (25.6%), and persistent-mild (18.2%). Compared to the persistent-mild trajectory, both stable-moderate and persistent-severe IA trajectories were associated with higher baseline NLR (stable-moderate: OR = 1.58, 95% CI: 1.11, 2.26; persistent-severe: OR = 1.74, 95% CI: 1.06, 2.85) and SII (stable-moderate: OR = 1.47, 95% CI: 1.02, 2.11; persistent-severe: OR = 1.81, 95% CI: 1.07, 3.05). For OD, the stable-moderate trajectory (vs. asymptomatic) was associated with higher MLR (OR = 1.70, 95% CI: 1.01, 2.88) and SII (OR = 1.52, 95% CI: 1.01, 2.31). No significant associations were observed for HI trajectories (all P > 0.05).</p><p><strong>Conclusion: </strong>Distinct ADHD symptom trajectories were identified. NLR and SII were associated with specific IA trajectories, suggesting a potential link between systemic inflammation and ADHD symptom persistence.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121611"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in resting-state EEG microstates and working memory in first-episode, medication-naïve major depressive disorder.","authors":"Yuhang He, Fengchun Wu, Zhendong Zhang, Shuyun Huang, Wanting Xu, Zixuan Liu, Ling Yang, Kunrong Lin, Jingping Wu, Bingxin Chen, Hehua Li, Kai Wu, Mei F O N G Lam, Yuanyuan Huang","doi":"10.1016/j.jad.2026.121649","DOIUrl":"10.1016/j.jad.2026.121649","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment shows notable sex-related variability in major depressive disorder (MDD), yet the neurophysiological mechanisms underlying these differences remain unclear. Using resting-state EEG microstates as an index of large-scale neural dynamics, this study aimed to examine sex differences in microstate characteristics and their associations with cognitive function in MDD.</p><p><strong>Methods: </strong>A total of 197 first-episode, medication-naïve patients with MDD underwent resting-state EEG recording and cognitive assessment using the MATRICS Consensus Cognitive Battery. Microstate temporal parameters were extracted for canonical microstate classes (A-D). Between-group comparisons were conducted using independent-samples t-tests with false discovery rate (FDR) correction, and associations between microstate metrics and cognitive performance were examined using Spearman correlations.</p><p><strong>Results: </strong>Female patients showed significantly poorer WM performance compared with male patients (p_fdr = 0.015), despite comparable demographic and clinical features. Robust sex differences emerged in microstate coverage: males displayed greater coverage of microstates A and B, whereas females exhibited greater coverage of microstate C (all p_fdr < 0.05). Transition probabilities also differed, with males showing higher D → A and lower D → C transitions (both p_fdr = 0.012). Among the microstate metrics demonstrating sex differences, only microstate A coverage was significantly associated with WM performance (r = 0.153, p = 0.032).</p><p><strong>Conclusions: </strong>These findings reveal sex-specific alterations in intrinsic network dynamics in early-course MDD and suggest that differential engagement of sensory-attentional neural states may contribute to sex-linked vulnerability in WM dysfunction. Microstate parameters may serve as electrophysiological markers for identifying sex-dependent neurocognitive mechanisms in depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121649"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal interference stimulation (TIS) for major depressive disorder: right lingual gyrus as a predictor.","authors":"Chuhao Zhang, Yiqing Yang, Cuihan Wang, Lijun Wang, Wenjie Sun, Chenjing Mu, Zhihong Feng, Nannan Liu, Xueyi Guan, Yong Lu, Shen Li, Chencheng Zhang, Jie Li","doi":"10.1016/j.jad.2026.121660","DOIUrl":"10.1016/j.jad.2026.121660","url":null,"abstract":"<p><strong>Background: </strong>Temporal interference stimulation (TIS) enables selective modulation of deep-brain targets without cortical activation, yet its therapeutic utility in major depressive disorder (MDD) remains unknown. Therefore, this multicenter, randomized controlled trial evaluated right-amygdala targeted TIS for MDD and identified predictors of treatment response.</p><p><strong>Methods: </strong>This study was a secondary analysis of a multicenter, randomized, double-blind, sham-controlled trial. Seventy-six MDD patients were enrolled across Tianjin Anding Hospital and Shanghai Ruijin Hospital and randomly assigned in a 1:1 ratio to active or sham groups. Resting-state functional MRI (rs-fMRI) and 17-item Hamilton Depression Rating Scale (HDRS-17) assessments were obtained at baseline, and clinical outcomes were evaluated at weeks 3 and 8. Within the active group, patients were categorized as responders or nonresponders based on week-8 HDRS-17 outcomes. Baseline amplitude of low-frequency fluctuations (ALFF) was compared between groups using two-sample t-tests. Associations between the identified regions and symptom improvement were examined using partial correlations. Logistic regression and ROC analyses were used to evaluate the predictive value of baseline ALFF measures for treatment response. The study was registered with ClinicalTrials.gov, NCT06477276.</p><p><strong>Results: </strong>14 patients (44%) responded to active TIS. Responders showed significantly lower baseline ALFF in the right lingual gyrus (GRF voxel p < 0.001, cluster p < 0.05, one-tailed). Right lingual gyrus ALFF was negatively correlated with HDRS-17 improvement (r = -0.696, p < 0.001). Logistic regression confirmed its predictive value (Model 1: OR = 0.016, 95% CI = 0.000 to 0.915, p = 0.045; Model 2 adjusted for age: OR = 0.000, 95% CI = 0.000 to 0.125, p = 0.011). ROC analysis yielded an AUC of 0.714 (p = 0.040, 95% CI = 0.550 to 0.893).</p><p><strong>Conclusion: </strong>Right-amygdala TIS improves depressive symptoms, and lower baseline right lingual gyrus ALFF emerged as a promising biomarker for predicting response.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121660"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding ACEs and suicide risk in depressed adolescents: The mediating effects of self-hate and anhedonia.","authors":"Ziyu Ye, Xiaonan Xu, Jinyu Li, Ji-Tao Li, Jing-Xu Chen, Tian-Mei Si, Yun-Ai Su","doi":"10.1016/j.jad.2026.121659","DOIUrl":"10.1016/j.jad.2026.121659","url":null,"abstract":"<p><strong>Objective: </strong>Although adverse childhood experiences (ACEs) have been recognized as a crucial risk factor for suicide, how self-hate and anhedonia mediate this relationship remains understudied. This gap is particularly pronounced among adolescent patients with major depressive disorder (MDD), where clarifying these connections is pivotal for developing effective suicide prevention and intervention strategies.</p><p><strong>Methods: </strong>This study included 159 adolescent inpatients diagnosed with MDD. Diagnoses of MDD and suicide risk were assessed using the Mini-International Neuropsychiatric Interview (MINI). ACEs were measured with the adverse childhood experiences international questionnaire (ACE-IQ), while self-hate and anhedonia were evaluated using the self-hate scale (SHS) and the anhedonia scale for adolescents (ASA), respectively. Temperament characteristics were assessed with the revised early adolescent temperament questionnaire (EATQ-R). Mediation and moderation analyses were performed using the PROCESS macro in SPSS.</p><p><strong>Results: </strong>ACEs were positively associated with suicide risk, a relationship that was serially mediated by self-hate and anhedonia. Regarding moderating effects, social support acted as a protective factor against ACEs-related self-hate. Temperamental surgency moderated the relationships between ACEs and both self-hate and suicide risk. Furthermore, temperamental effortful control buffered the link between ACEs and both self-hate and anhedonia, as well as the association between self-hate and suicide risk.</p><p><strong>Conclusion: </strong>The sequential mediation model elucidates the potential pathways linking early-life traumas to adolescent mental health outcomes. It also offers important evidence-based support for suicide prevention among depressed adolescents with diverse temperaments.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121659"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right DLPFC stimulation attenuates negative evaluation in social anxiety: An rTMS study.","authors":"Huoyin Zhang, Shihan Wu, Mingxue Cao, Luoyi Zhang, Yumeng Jin, Zihan Zhou, Weijia Peng, Yi Lei","doi":"10.1016/j.jad.2026.121636","DOIUrl":"10.1016/j.jad.2026.121636","url":null,"abstract":"<p><strong>Background: </strong>Social anxiety is characterized by excessive fear generalization to social evaluation. Although rTMS shows promise in modulating anxiety, its effects on negative evaluation in social anxiety remain unclear. This study investigated if rTMS targeting the right DLPFC could modulate negative evaluation expectancy in individuals with high social anxiety.</p><p><strong>Methods: </strong>Using a randomized controlled design, 33 individuals with high social anxiety (LSAS ≥38) were randomly assigned to rTMS (n = 15) or sham (n = 18) groups. Single-session 1 Hz rTMS (1200 pulses, 80% RMT) was applied to the right dorsolateral prefrontal cortex (DLPFC) using neuronavigation. Expectancy ratings for conditioned (CS+/CS-) and generalization (GS1-4) stimuli were assessed during early and late generalization.</p><p><strong>Results: </strong>Both groups demonstrated successful acquisition. During generalization, significant main effects for time and stimulus type were observed. Critically, the rTMS group showed lower US-expectancy ratings than sham selectively for the intermediate-similarity stimulus (GS3) during early generalization, with no group differences for other stimuli or in the late phase. Polynomial trend analyses revealed a significant time × group interaction in the quadratic (curvature) component, reflecting an early-phase between-group difference in curvature.</p><p><strong>Conclusions: </strong>Offline 1 Hz rTMS over the right DLPFC modulated negative-evaluation generalization in a phase- and stimulus-specific manner. The findings suggest right-DLPFC stimulation primarily influences the shape of the early generalization gradient under ambiguity, rather than producing a uniform reduction across stimuli. Durability and clinical relevance require further investigation.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121636"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of cognitive behavioral therapy and pharmacotherapy on cognitive function in patients with major depressive disorder: A propensity-weighted longitudinal study.","authors":"Yuki Kobayashi, Jinichi Hirano, Atsuo Nakagawa, Ryo Takemura, Satoshi Umeda, Miyuki Tajima, Sachiko Noda, Mizuki Amano, Kei Kamiya, Masaru Mimura, Hiroyuki Uchida, Nariko Katayama","doi":"10.1016/j.jad.2026.121632","DOIUrl":"10.1016/j.jad.2026.121632","url":null,"abstract":"<p><strong>Background: </strong>Neurocognitive dysfunction is a core feature of major depressive disorder (MDD), predicting relapse, persisting after remission, and hindering functional recovery. Although cognitive behavioral therapy (CBT) and pharmacotherapy are both established treatments, their differential effects on specific neurocognitive domains remain poorly characterized. We investigated the distinct neurocognitive effects of CBT and pharmacotherapy in patients with MDD.</p><p><strong>Methods: </strong>This study assessed 69 patients with MDD treated with either manual-based CBT combined with pharmacotherapy (n = 41) or pharmacotherapy alone (n = 28). Neurocognitive function was evaluated using the Brief Assessment of Cognition in Schizophrenia, whereas depressive and anxiety symptoms were assessed using the Montgomery-Åsberg Depression Rating Scale and Generalized Anxiety Disorder-7, respectively. Inverse probability of treatment weighting (IPTW) based on propensity scores balanced baseline characteristics between groups. Pre-post changes in neurocognitive domains were assessed using repeated-measures ANOVA. Robustness of the findings was evaluated using multiple imputation and mixed-effects models for repeated measures (MMRM).</p><p><strong>Results: </strong>After IPTW adjustment, baseline characteristics were well balanced. A significant group × time interaction favoring CBT emerged for verbal memory (F[1,95] = 4.59, p = .035, η² = 0.046). Improvements in executive function were observed only in the CBT group (p = .005, Cohen's d = 0.442). Findings were consistent with the results using multiple imputation and MMRM.</p><p><strong>Conclusion: </strong>CBT combined with pharmacotherapy was associated with improvement in verbal memory compared to pharmacotherapy alone. These findings highlight the domain-specific neurocognitive benefits of combining CBT with pharmacotherapy and its potential to target neurocognitive dysfunction in MDD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121632"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the SPISE index with depression: comparison with anthropometric obesity indices and surrogate markers of insulin resistance.","authors":"Myong-Won Seo, Hyun-Seo Ko, Hyun Chul Jung","doi":"10.1016/j.jad.2026.121654","DOIUrl":"10.1016/j.jad.2026.121654","url":null,"abstract":"<p><strong>Background: </strong>This study examined the relationship between the SPISE index and depression and compared its discriminative performance with anthropometric obesity indices and other surrogate markers of insulin resistance.</p><p><strong>Method: </strong>Data from 18,684 adults aged 19-64 years participating in the Korean National Health and Nutrition Examination Survey (2014-2020) were analyzed. After age- and sex-matching, 1888 participants with depression and 1888 without depression were included. Anthropometric obesity indices included body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). Surrogate markers of insulin resistance included triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C), triglycerides-glucose index (TyG), and SPISE index. Receiver operating characteristic (ROC) analyses were used to compare predictive performance for depression, assessed by the Patient Health Questionnaire-9 (PHQ-9). In addition, multivariable logistic regression analysis was conducted to examine the association between SPISE quartiles and depression.</p><p><strong>Result: </strong>The SPISE index showed superior discriminative performance for depression (AUC: 83.3%) relative to BMI (AUC: 79.7%), waist circumference (AUC: 78.7%), waist-to-height ratio (ROC-AUC: 78.3%), the TyG index (AUC: 76.5%), and TG/HDL-C (AUC: 76.4%). In addition, progressively lower SPISE quartiles were independently associated with higher odds of depression, with adjusted odds ratios of 3.73 for Q2, 8.77 for Q3, and 24.88 for Q4 compared with the highest quartile (Q1).</p><p><strong>Conclusion: </strong>The SPISE index demonstrated superior discriminative performance for identifying depression and lower SPISE levels were independently and progressively associated with higher odds of depression. These findings suggest that SPISE may be a simple and practical marker associated with depression in South Korean population.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121654"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative balance score, inflammatory biomarkers, and risk of psychiatric disorders and suicide attempts: A prospective cohort study.","authors":"Yichun Wu, Yuheng Yuan, Xiaomai Zhou, Shufan Duan, Yangqian Chu, Linzhou Zhu, Yinda Zhu, Xin Yang, Jun Wu, Yueping Shen, Jingting Jiang","doi":"10.1016/j.jad.2026.121672","DOIUrl":"10.1016/j.jad.2026.121672","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress and inflammation contribute to psychiatric disorders and suicide attempt (SA), yet the prospective associations of a comprehensive oxidative balance score (OBS) with these outcomes, and the mediating role of inflammatory biomarkers, remain unclear.</p><p><strong>Methods: </strong>This study included 143,851 UK Biobank participants with complete data and free of psychiatric disorders and SA at baseline. We constructed an OBS from 16 dietary (DOBS) and 4 lifestyle (LOBS) components. Cox models assessed associations with incident anxiety, depression, substance use disorder (SUD), schizophrenia (SCZ), bipolar disorder (BD), and SA. Mediation analyses evaluated inflammatory biomarkers.</p><p><strong>Results: </strong>Over 13.1 years of median follow-up, 13,448 participants developed psychiatric disorders (4966 anxiety; 4580 depression; 5941 SUD; 48 SCZ; 107 BD; 225 SA). Compared with the lowest quartile, the highest OBS quartile showed markedly lower risks of any psychiatric disorder and SA (HR: 0.58, 95% CI: 0.54-0.61). Higher DOBS and LOBS also showed protective associations. For individual outcomes, higher OBS was linked to reduced risks of anxiety (HR: 0.87, 95% CI: 0.80-0.95), depression (HR: 0.75, 95% CI: 0.68-0.82), SUD (HR: 0.30, 95% CI: 0.27-0.33), and SA (HR: 0.55, 95% CI: 0.34-0.89) after FDR correction, with a non-significant trend for SCZ and BD. Inflammatory biomarkers significantly mediated these associations, explaining 0.22%-11.65% of the associations.</p><p><strong>Conclusions: </strong>Higher OBS, DOBS, and LOBS were associated with lower risks of psychiatric disorders and SA, partly through inflammatory biomarkers. Antioxidant-oriented diet and lifestyle patterns may support long-term mental health.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121672"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal recovery as outcome measure in mental health research: A meta-analysis on the sensitivity to change properties of the Recovery Assessment Scale.","authors":"T A D Pelgrim, K Kleine Schaars, R Moldovan, M Deen, R van Westrhenen","doi":"10.1016/j.jad.2026.121250","DOIUrl":"10.1016/j.jad.2026.121250","url":null,"abstract":"<p><p>Personal recovery is an increasingly used outcome for evaluating the effect of interventions on mental health disorders like affective and anxiety disorders, emphasizing living a meaningful life despite psychiatric challenges. The Recovery Assessment Scale (RAS) is a widely used measure of personal recovery with strong psychometric properties, but evidence for its sensitivity to change is limited. We conducted a systematic review and meta-analysis of 27 randomized controlled trials, found through systematic search on December 8th, 2022, which was updated in March 2024, to evaluate whether the RAS is sensitive to measuring change after interventions. Among the included randomized controlled trials, several focused on affective disorders, allowing us to examine the RAS in diagnostic groups directly relevant to affective disorder research. Results showed that participants in intervention groups demonstrated significantly greater pre-post changes in RAS scores compared to control groups for total RAS scores, with a small overall effect size (hedges g = 0.249). This effect was moderated by participants' diagnoses, but not by the specific RAS version, length of follow-up period, significant clinical outcome measured or baseline RAS scores. No significant findings were found for subdomain scores. Our results demonstrate that the RAS can detect change in a randomized controlled setting, although this design cannot fully isolate intervention effects from the instrument's inherent responsiveness. A better understanding of the scale's ability to capture changes in personal recovery can inform the development of more effective, personalized interventions, ultimately improving the well-being and quality of life of individuals with psychiatric disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"121250"},"PeriodicalIF":4.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}