Journal of affective disorders最新文献

{"title":"Corrigendum to “Neutrophil to albumin ratio as a novel associated factor for depression; results from NHANES 2017–2018” [J. Affect. Disord., 379 (2025) 72–78]","authors":"Amirhomayoun Atefi , Aref Ghanaatpisheh , Mohammad Fereidouni , Ghazaleh Habibi , Fateme Takrimi Niarad , Ehsan Aboutaleb","doi":"10.1016/j.jad.2025.119553","DOIUrl":"10.1016/j.jad.2025.119553","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119553"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The moderating role of sexual identity centrality in the association between gay community stress and social anxiety among sexual minority men","authors":"Zachary A. Soulliard ,&nbsp;Anthony J. Maiolatesi ,&nbsp;Robert B. Manning III ,&nbsp;Katie Wang ,&nbsp;John E. Pachankis","doi":"10.1016/j.jad.2025.119755","DOIUrl":"10.1016/j.jad.2025.119755","url":null,"abstract":"<div><div>Gay community stress has been linked to social anxiety among sexual minority men; however, the moderating role of identity-related processes (e.g., sexual identity centrality) has yet to be examined in this association. The present study investigated the association between gay community stress and two measures of social anxiety (i.e., self-reported social anxiety symptoms and interviewer-based diagnostic assessment of social anxiety disorder), as well as the moderating role of sexual identity centrality. Data come from the baseline assessment of a randomized controlled trial testing an LGBTQ-affirmative cognitive behavioral therapy intervention with 251 sexual minority men between the ages of 18–35. Results showed that gay community stress was significantly associated with social anxiety symptoms and social anxiety disorder diagnosis. Sexual identity centrality moderated these associations, such that the link between gay community stress and both social anxiety assessments was stronger among participants with higher levels of sexual identity centrality. These significant findings remained even after accounting for sexual orientation-based discrimination and general life stress. Future research can investigate how the interaction between gay community stress, sexual identity centrality, and social anxiety develops over time to inform interventions aimed at mitigating social distress among sexual minority men.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119755"},"PeriodicalIF":4.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mood stabilizers: Insights from users' perceptions","authors":"M.F. Tagni ,&nbsp;S.A. Strejilevich ,&nbsp;S. Camino ,&nbsp;E. Carballo ,&nbsp;M. Guglielmetti ,&nbsp;L. López Escalona ,&nbsp;M. Oppel ,&nbsp;L. Sabattini ,&nbsp;A. Szmulewicz","doi":"10.1016/j.jad.2025.119753","DOIUrl":"10.1016/j.jad.2025.119753","url":null,"abstract":"<div><h3>Background</h3><div>Opinions and subjective perceptions regarding psychopharmacological treatment have proven to be strong predictors of quality of life, adherence, and general outcomes, as well as a rich source of data for research. Although mood stabilizing agents (MSA) represent the cornerstone of the treatment of bipolar disorders (BDs), data on the experiences of patients undergoing treatment with these drugs are scarce. We aimed to explore and compare user-reported data on four first-line MSA and identify predictors of treatment satisfaction.</div></div><div><h3>Methods</h3><div>We conducted a quantitative analysis of a random sample of 200 posts specifically related to first-line mood stabilizers (lithium, lamotrigine, valproate, and quetiapine) from individuals undergoing long-term treatment for BDs. Demographical, clinical, somatic, and emotional/psychological side-effects and treatment-related data were analyzed.</div></div><div><h3>Results</h3><div>This study found that the reported levels of satisfaction with MSAs were notably high. Lamotrigine received higher satisfaction ratings than quetiapine and valproate, after including age, sex, dose, and length of treatment in the models. Lithium was rated higher than valproate and quetiapine, although this difference did not reach statistical significance. Obsessive-compulsive symptoms, emotional hyperreactivity, cognitive symptoms, anxiety, weight gain, and gastrointestinal symptoms emerged as significant predictors of treatment dissatisfaction.</div></div><div><h3>Conclusions</h3><div>The findings of this study underscore the significant role that emotional and psychological side effects play in treatment dissatisfaction during MSA use. Both research and clinical decisions should consider the subjective experiences of patients undergoing MSA treatment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119753"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying potential pathogenic oxidative stress-related genes in depression through multi-omics summary-data-based Mendelian randomization analysis.","authors":"Junxiang Cheng, Zhifen Liu, Ruifang Zhu, Qia Liu, Hong Han, Na Liu, Juan Shi, Shifan Han, Ning Ma","doi":"10.1016/j.jad.2025.119734","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119734","url":null,"abstract":"<p><strong>Purpose: </strong>The relationship between oxidative stress-related genes (OSGs) and depression remains unclear. This study investigates causal associations between OSGs and depression susceptibility to elucidate their roles in this mental health condition.</p><p><strong>Methods: </strong>This study employed a Summary-data-based Mendelian randomization (SMR) approach to investigate the associations between oxidative stress-related genes (OSGs) and depression risk. Differentially expressed genes (DEGs) associated with depression were identified from merged Gene Expression Omnibus transcriptome data and intersected with OSGs from GeneCards to define depression-related OSGs (DeOSGs). SMR analyses using methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein quantitative trait loci (pQTL) data from large-scale consortia and cohorts evaluated associations between DeOSG methylation, expression, and protein levels with depression risk. Colocalization analysis identified shared causal variants between traits. Functional enrichment and validation using FinnGen cohorts further supported findings.</p><p><strong>Results: </strong>We identified 488 DeOSGs in depression patients. SMR analyses across mQTL, eQTL, and pQTL levels identified 130 methylation sites, 28 genes, and three proteins linked to depression risk. Ten CpG sites and three DeOSGs showed strong colocalization evidence. Integrative analysis identified four genes (BRAF, CUTA, SLC27A3, and SMARCA4) as potential candidates influencing depression risk through methylation and expression changes. External validation in the FinnGen cohort confirmed a negative association for CUTA expression in blood eQTL data.</p><p><strong>Conclusions: </strong>This study identified BRAF, CUTA, SLC27A3, and SMARCA4 as influencing depression risk through methylation and expression changes. These findings provide potential targets for future therapeutic exploration and biomarker development.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119734"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neutrophil percentage-to-albumin ratio mediates the association between depression and all-cause mortality in U.S. adults: Evidence from NHANES 2009-2018.","authors":"Kunxiu Wang, Gaofeng Liu, Yuchen Pan, Siyu Li, Xiaoling Zhu, Hui Qu, Xuesong Liang, Song Chen, Wenbin Fu","doi":"10.1016/j.jad.2025.119736","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119736","url":null,"abstract":"<p><strong>Background: </strong>Depression significaantly reduces the quality of life for hundreds of millions of people globally. Evidence suggests associations among depression, the neutrophil percentage-to-albumin ratio (NPAR), and all-cause mortality (ACM). However, the interrelationship was not elucidated. This study aimed to unveil whether NPAR mediates the correlation between depression and ACM.</p><p><strong>Methods: </strong>A cross-sectional study was carried out based on data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. ACM data were collected up to December 31, 2019. Weighted binary logistic regression and generalized linear regression models were leveraged to unravel pairwise associations among depression scores, NPAR, and ACM. Mediation analysis was performed to evaluate the potential mediating effects of NPAR on the relationship between depression and ACM.</p><p><strong>Results: </strong>18,709 participants were encompassed. In the fully adjusted model, depression scores (OR [95 % CI]: 1.035 [1.012, 1.058]) and NPAR (OR [95 % CI]: 1.15 [1.108, 1.194]) were significantly positively linked to ACM. Depression scores were positively correlated with NPAR (β [95 % CI]: 0.014 [0.001, 0.026]). NPAR mediated 5.27 % of the total association between depression and ACM. Subgroup analyses revealed that the mediating effect of NPAR was more prominent in specific populations.</p><p><strong>Conclusion: </strong>Among U.S. adults, depression significantly increases the risk of ACM, and this relationship is mediated by NPAR. The mediating effect of NPAR varied by sex, age, race, and health status. These findings fill gaps in the existing literature.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119736"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of multi-omics and crowdsourcing assessment of placenta-brain axis biomarkers for predicting neurodevelopmental disorders.","authors":"Yimin Zhang, Heyue Jin, Juan Tong, Hong Gan, Fangbiao Tao, Yumin Zhu","doi":"10.1016/j.jad.2025.119732","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119732","url":null,"abstract":"<p><p>Neurodevelopmental disorders (NDDs) are heterogeneous and multifactorial psychiatric disorders with abnormalities in multiple biological domains. It is increasingly recognized that the placenta profoundly influences fetal neurodevelopment due to the finding of the placenta-brain axis. However, few studies have investigated the interplay between placenta dysfunction and NDDs, especially autism spectrum disorder (ASD) symptoms, attention-deficit/hyperactivity disorder (ADHD) symptoms, and intellectual disability (ID) symptoms, by using integrative multi-omics data. Here, we performed an analysis of transcriptomic and non-targeted metabolomic individually and integratively to characterize the placental multi-omics profiles of children with NDDs in Ma'anshan Birth Cohort, and to identify biomarkers associated with the placenta-brain axis. Integrating transcriptome and metabolome perspectives, we further conducted a multi-omics machine learning workflow to discover reliable placental biomarkers for early diagnosis of these NDDs in the participants. Integrative analysis of differentially expressed genes and metabolites revealed a common intrauterine regulation mechanism for ASD symptoms and ADHD symptoms. Combined with machine learning, prediction models were constructed and 99.7 % of ASD symptoms, 99.0 % of ADHD symptoms, and 95.7 % of ID symptoms were correctly classified. This is the first study combining transcriptomics and metabolomics from the perspective of the placental-brain axis in humans, which contributes to a deeper understanding about the pathogenesis of the NDDs and may potentially pave the way toward molecular diagnosis of different disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119732"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural differentiation of anxiety: An EEG-based comparative study of panic disorder and major depressive disorder.","authors":"Seok-Im Lee, Joon Hwan Jang, Jung-Seok Choi, Hee Yeon Jung, Jun-Young Lee, So Young Yoo","doi":"10.1016/j.jad.2025.119748","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119748","url":null,"abstract":"<p><strong>Background: </strong>Panic disorder (PD) and major depressive disorder (MDD) frequently co-occur, leading to poorer prognosis. Although anxiety symptoms in both conditions appear similar, their underlying mechanisms may differ, as indicated by shared and distinct features in theoretical models and neurophysiological findings. This study investigates EEG-based neural differentiation of anxiety between PD and MDD, integrating the Tripartite Model and Five-Factor Structure.</p><p><strong>Methods: </strong>This retrospective study analyzed resting-state electroencephalographic (EEG) data from 75 participants (PD: n = 35; MDD: n = 40). Generalized estimating equations examined group differences in EEG absolute power (μV²) and asymmetry across frontal, central, and posterior regions. These differences were assessed in relation to factors associated with Anxious Arousal and Negative Affect from the Five-Factor Structure, measured via the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), across five frequency bands (delta, theta, alpha, beta, gamma). Additional analyses explored subregional differences in temporal, parietal, and occipital areas.</p><p><strong>Results: </strong>While Anxious Arousal showed no distinct neural patterns, Negative Affect revealed significant group differences in posterior beta-band asymmetry. In the posterior temporal region, the PD group exhibited increased rightward asymmetry, whereas the MDD group showed decreased rightward asymmetry. Significant group differences in posterior parietal asymmetry were also observed for Negative Affect, but these contrasting trends were not significant.</p><p><strong>Conclusions: </strong>The distinct neurophysiological patterns for Negative Affect observed between PD and MDD may serve as potential neurobiological markers and support the exploration of treatment neuromodulation strategies targeting specific neural circuits, particularly in posterior brain regions, to alleviate anxiety symptoms.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119748"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol use across trials of psychological interventions for bipolar: A systematic review and meta-analysis.","authors":"Lauren Halsall, Steven Jones, Zoe Swithenbank, Anastasia Ushakova, Laura Goodwin","doi":"10.1016/j.jad.2025.119745","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119745","url":null,"abstract":"<p><strong>Background: </strong>Clinical guidelines recommend psychological interventions for bipolar disorder (BD). However, although BD commonly co-occurs with alcohol use disorder (AUD), it is not established how frequently individuals with AUD are excluded from BD psychological intervention trials, or whether this exclusion impacts trial efficacy. Consequently, it is unclear whether evidenced-based treatment decisions can be made for this population.</p><p><strong>Methods: </strong>A systematic review of RCTs of psychological interventions for BD (PROSPERO ref.: CRD42023474548) was conducted to explore the proportion of trials i) reporting alcohol-related exclusion criterion, and/or ii) measuring alcohol use at follow-up. Random effects meta-analyses with sub-group comparisons were also conducted, to investigate whether intervention efficacy differed between trials including and excluding individuals with an AUD.</p><p><strong>Results: </strong>Across the 92 trials identified, 31 (33.7 %) reported alcohol-related exclusion, and only 3 (3.3 %) measured alcohol use at follow-up. The pooled effect sizes for depressive or manic symptoms did not significantly differ between trials including or excluding individuals with co-occurring AUD across the main analyses, although these may be sensitive to methodological changes. Certainty of evidence was moderate.</p><p><strong>Conclusions: </strong>Overall, findings indicate that alcohol-related exclusion is common across trials of psychological interventions, but that intervention efficacy does not significantly differ between trials including and excluding individuals with AUD. Consequently, it is recommended that intervention studies do not exclude people with AUD, in order for evidenced-based treatment to be evaluated in those with co-occurring problems.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119745"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between regional prescriptions of lithium and clozapine and suicide mortality in children and adolescents in France between 2014 and 2019.","authors":"Edouard Guez, Alejandro Rojas-Chaves, Judith Van Der Waerden, Maria Melchior, Hugues Pellerin, Angèle Consoli, David Cohen, Xavier Benarous","doi":"10.1016/j.jad.2025.119738","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119738","url":null,"abstract":"<p><strong>Introduction: </strong>The protective effect of lithium and clozapine against suicide risk was reported in adults but remains unclear in the pediatric population.</p><p><strong>Method: </strong>This cross-sectional ecological study utilized a combination of health registers to collect information on drug prescriptions (OPENMEDIC national health insurance database), mortality (CepiDC national mortality register), medical demography (CNOM data) and social disadvantage (INSEE data), extracting data on subjects aged 0 to 19 years living in France from 2014 to 2019. The relationships between the regional variabilities in lithium and clozapine dispensations and different death rates: by suicide and self-injury, by mental and behavioral disorders, and all causes.</p><p><strong>Results: </strong>Dispensations of lithium and clozapine varied widely by region. Inter-regional variabilities in lithium and clozapine dispensations were associated with mortality by suicide and self-injury in simple regression models (respectively, β = -0.006, p = .032 and β - 0.0104, p = .009) but not for other causes of mortality. Both dispensations were strongly correlated with social deprivation scores and the density of adult psychiatrists. In robust and multiple regression models, the level of association with suicide and self-injury mortality remained significant for clozapine but not for lithium.</p><p><strong>Discussion: </strong>Keeping in mind the limitations inherent to spatial study design, these preliminary findings are consistent with a possible antisuicide effect of clozapine in the pediatric population, while the effect of lithium is less clear. Even in the context of the French free-of-charge healthcare system, major spatial inequities exist in access to these medications for youths, partly underlaid by social disparities and medical demography.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119738"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of dietary habits, inflammatory dietary index, and lifestyle factors with depressive symptoms: A cross-sectional study of 53,539 individuals with thyroid nodules","authors":"Lijun Li ,&nbsp;Ying Li ,&nbsp;Hui Li ,&nbsp;Yi Zhou ,&nbsp;Xue He ,&nbsp;Pingting Yang ,&nbsp;Xingxing Wang ,&nbsp;Jiayi Zhu ,&nbsp;Yinglong Duan ,&nbsp;Jianfei Xie ,&nbsp;Andy S.K. Cheng","doi":"10.1016/j.jad.2025.119735","DOIUrl":"10.1016/j.jad.2025.119735","url":null,"abstract":"<div><h3>Background</h3><div>Depressive symptoms are closely associated with thyroid nodules (TNs). Lifestyle and dietary factors have been linked to depressive symptoms. Therefore, this study aimed to investigate the associations between dietary patterns-including dietary diversity, protein-enriched dietary, inflammatory dietary patterns, dietary habits and depressive symptoms in individuals with TNs.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 53,539 participants who underwent physical examinations between January 2017 and March 2024. Participants completed self-reported questionnaires on demographic characteristics, physical health, activity levels, dietary index scores, dietary habits, and depressive symptoms.</div></div><div><h3>Results</h3><div>Participants were female (OR: 1.38, 95 % CI: 1.30–1.46), divorced or widowed (OR: 1.56, 95 % CI: 1.31–1.85), had a higher waist-hip ratio, and (OR: 2.22; 95 % CI: 1.43–3.43) and engaged in prolonged sedentary time (OR: 1.51; 95 % CI: 1.41–1.62) were more likely to report depressive symptoms. Regarding dietary factors, an anti-inflammatory dietary (OR: 0.79; 95 % CI: 0.75–0.83) and a protein-enriched dietary (OR: 0.87; 95 % CI: 0.83–0.92) were associated with a lower risk of depressive symptoms. However, irregular eating (OR: 2.00, 95 % CI: 1.81–2.21), overeating frequently (OR: 1.87; 95 % CI: 1.70–2.05), and being a former drinker (OR: 1.43, 95 % CI: 1.19–1.71) were associated with a higher risk of depressive symptoms in individuals with TNs.</div></div><div><h3>Conclusions</h3><div>Unhealthy eating behaviors and prolonged sedentary time were associated with a higher risk of depressive symptoms in individuals with TNs, while anti-inflammatory and protein-rich diets were associated with lower odds. These findings suggest potential links between dietary and lifestyle factors and depressive symptoms, which may warrant further investigation in prospective or interventional studies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119735"},"PeriodicalIF":4.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}