Journal of affective disorders最新文献

{"title":"Cross-cultural measurement equivalence of the seven item general anxiety disorder scale (GAD-7) in college students of six countries of Latin American","authors":"Esteban Moreno-Montero ,&nbsp;Rodrigo Moreta-Herrera ,&nbsp;Jose A. Rodas ,&nbsp;Xavier Oriol-Granado ,&nbsp;Diana Ximena Puerta-Cortés ,&nbsp;Daniela Ferrufino-Borja ,&nbsp;Renzo Gismondi Diaz ,&nbsp;Marlon Elías Lobos Rivera ,&nbsp;Antonio Samaniego-Pinho ,&nbsp;Marcelo Buenahora-Bernal ,&nbsp;Claudio Rojas-Jara ,&nbsp;Maribel Vega-Arce","doi":"10.1016/j.jad.2025.03.188","DOIUrl":"10.1016/j.jad.2025.03.188","url":null,"abstract":"<div><h3>Objective</h3><div>To identify cross-cultural validity evidence for the Spanish version of the Generalised Anxiety Disorder Scale-7 (GAD-7) in a sample of university students from six Latin American countries.</div></div><div><h3>Method</h3><div>This study employed a descriptive, psychometric, and cross-sectional design to examine the factorial validity of the GAD-7, its measurement equivalence across nationalities, and item-level discrimination and difficulty parameters.</div></div><div><h3>Participants</h3><div>The sample consisted of 2278 university students from six Latin American countries (Bolivia, Colombia, Chile, Ecuador, El Salvador, and Paraguay) with a mean age of 21.9 years (SD = 5.41, range = 16–59). The sample was composed of 37.4 % men (<em>n</em> = 851) and 62.6 % women (<em>n</em> = 1427).</div></div><div><h3>Results</h3><div>The findings confirmed the unidimensional structure of the GAD-7, along with measurement equivalence across nationalities from the six countries. The instrument demonstrated excellent internal consistency, and the discrimination and difficulty parameters for the items were found to be appropriate.</div></div><div><h3>Conclusions</h3><div>The GAD-7 is a valid and reliable instrument for assessing generalised anxiety in university students from Bolivia, Colombia, Chile, Ecuador, El Salvador, and Paraguay. Nationality does not introduce variability in the measure, supporting its cross-cultural applicability.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 598-606"},"PeriodicalIF":4.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational attainment and cognitive behavioral therapy treatment outcome in late-life depression: A secondary analysis of a randomized controlled trial","authors":"S.K. Gerhards ,&nbsp;M. Luppa ,&nbsp;A.E. Zülke ,&nbsp;A. Pabst ,&nbsp;M. Claus ,&nbsp;B. Bewernick ,&nbsp;M. Elsaesser ,&nbsp;N. Zehender ,&nbsp;M. Wagner ,&nbsp;O. Peters ,&nbsp;L. Frölich ,&nbsp;E. Schramm ,&nbsp;M. Hautzinger ,&nbsp;F. Jessen ,&nbsp;F.S. Dafsari ,&nbsp;S.G. Riedel-Heller","doi":"10.1016/j.jad.2025.03.189","DOIUrl":"10.1016/j.jad.2025.03.189","url":null,"abstract":"<div><h3>Aim</h3><div>The aim of this study is to investigate the association of different levels of educational attainment with the impact of Cognitive Behavioral Therapy for Late-Life Depression (LLD-CBT) compared to a supportive unspecific intervention (SUI).</div></div><div><h3>Methods</h3><div>A secondary analysis of the multicenter, randomized controlled trial “CBTlate” was conducted with <em>n</em> = 229 participants aged 60 years and older with moderate to severe depression who received either LLD-CBT (<em>n</em> = 115) or SUI (<em>n</em> = 114). Depressive symptoms as outcome were assessed with the 30-item Geriatric Depression Scale (GDS). Educational attainment was categorized according to the school and vocational education based system (CASMIN). Intention-to-treat analysis was performed using multilevel mixed effects linear models.</div></div><div><h3>Results</h3><div>While the model showed no significant overall effect of education on treatment outcome, analysis revealed a significant treatment effect for the low educational attainment group (group*time interaction, <em>x</em>^<em>2</em>(2) = 6.45, <em>p</em> = .040) with LLD-CBT being superior to SUI in the reduction of depressive symptoms from baseline to the end of treatment (Estimated Marginal Mean Difference (EMMD) = −5.30, 95 %-CI = −8.93 to −2.12) and to follow-up (EMMD = -7.34, 95 %-CI = −11.24 to −3.43). There was no corresponding significant effect for the medium and high educational group. In the low remission and response rates were significantly higher in the LLD-CBT compared to the SUI group at follow-up.</div></div><div><h3>Conclusion</h3><div>Participants may have responded differently to LLD-CBT and SUI depending on their previous school and vocational education. This may be taken into account for future research and potentially when treating patients with LLD and individualizing interventions for this patient group<strong>.</strong></div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 576-583"},"PeriodicalIF":4.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of optimism, self-efficacy, and resilience with life engagement among middle-aged and older adults with severe climate anxiety: Sensitivity of a path model","authors":"Nestor Asiamah ,&nbsp;Henry Kofi Mensah ,&nbsp;Edward Wilson Ansah ,&nbsp;Eric Eku ,&nbsp;Nana Benyi Ansah ,&nbsp;Emelia Danquah ,&nbsp;Cosmos Yarfi ,&nbsp;Isaac Aidoo ,&nbsp;Frank Frimpong Opuni ,&nbsp;Simon Mawulorm Agyemang","doi":"10.1016/j.jad.2025.03.180","DOIUrl":"10.1016/j.jad.2025.03.180","url":null,"abstract":"<div><h3>Background</h3><div>Life engagement is an important proxy of successful ageing that may depend on psychological capital factors (e.g., optimism, self-efficacy, and resilience), especially among older adults with severe climate anxiety. This study aimed to assess the association of optimism with life engagement and ascertain whether this relationship is mediated by self-efficacy and resilience among older adults with severe climate anxiety.</div></div><div><h3>Methods</h3><div>The data came from the Climate Psychology in Ageing Study 2024, a national survey involving 3994 middle-aged and older adults aged 50 years or over in Ghana. Multistage sampling was used to select the participants across Ghanaian cities, and the Climate Anxiety Scale was used to classify participants into severe, moderate, or mild climate anxiety. A path analysis (through structural equation modelling) was used to quantify the association. The sensitivity of the path model was investigated with data on moderate and mild climate anxiety.</div></div><div><h3>Results</h3><div>Optimism was associated with higher life engagement among older adults with severe and moderate climate anxiety but not among those with mild climate anxiety. Self-efficacy and resilience partially mediated the association of optimism with life engagement among older adults with severe and moderate climate anxiety but fully mediated this relationship among older adults with mild climate anxiety.</div></div><div><h3>Conclusion</h3><div>Psychological capital may be more strongly associated with life engagement among older adults with severe climate anxiety, and policy-driven human development programmes enhancing this capital can facilitate life engagement.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 607-619"},"PeriodicalIF":4.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay between childhood trauma, hopelessness, depressive symptoms, and mental pain in a large sample of patients with severe mental disorders: A network analysis","authors":"Stefano Barlati ,&nbsp;Marco Innamorati ,&nbsp;Antonio Vita ,&nbsp;Gabriele Nibbio ,&nbsp;Denise Erbuto ,&nbsp;Salvatore Sarubbi ,&nbsp;Valeria del Vecchio ,&nbsp;Mario Luciano ,&nbsp;Gaia Sampogna ,&nbsp;Giovanni Abbate-Daga ,&nbsp;Claudia Carmassi ,&nbsp;Giovanni Castellini ,&nbsp;Pasquale De Fazio ,&nbsp;Giorgio Di Lorenzo ,&nbsp;Marco Di Nicola ,&nbsp;Silvia Ferrari ,&nbsp;Arianna Goracci ,&nbsp;Carla Gramaglia ,&nbsp;Giovanni Martinotti ,&nbsp;Maria Giulia Nanni ,&nbsp;Maurizio Pompili","doi":"10.1016/j.jad.2025.03.185","DOIUrl":"10.1016/j.jad.2025.03.185","url":null,"abstract":"<div><h3>Background</h3><div>Mental pain represents a significant risk factor for suicidal behavior in severe mental disorders. The present study aims to investigate the interplay between childhood traumatic experiences, hopelessness, depressive symptoms and mental pain, using a network analysis approach in a large transdiagnostic sample of participants living in the community.</div></div><div><h3>Methods</h3><div>The present investigation was conducted using data gathered in a multicentric observational cross-section study organized as a joint project, including different Italian research and clinical settings. Considering the assessment tools adopted in the study, 12 different variables were included as nodes in the EBICglasso network analysis. Stability of the edges and of centrality indices were assessed using bootstrap procedures, considering case-dropping and node-dropping procedures.</div></div><div><h3>Results</h3><div>A total of 2147 participants were included in the analysis<strong>.</strong> Mental pain represents a central feature in a complex network of relationships, including traumatic experiences, hopelessness, and depressive symptoms. More in deatail, mental pain and, to a lesser extent, affective and cognitive depressive symptoms emerged as the most central and influential nodes of the network, highlighting the strong link existing between these aspects and their importance in the lives of people with mental disorders.</div></div><div><h3>Conclusions</h3><div>Results confirm the importance of mental pain as a transdiagnostic feature, requiring careful assessment and consideration in all patients, beyond the diagnostic categories and regardless of suicide risk. Assessing and managing the presence and severity of mental pain should be taken into account in clinical practice, in the perspective of providing significant clinical benefits, as well as relevant research insight.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 545-551"},"PeriodicalIF":4.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between social cognition, depressive symptoms and resilience among elderly people","authors":"XiWen Ding ,&nbsp;Yin Chen ,&nbsp;Ayizuhere Aierken ,&nbsp;YiLin Chen ,&nbsp;Ying Li","doi":"10.1016/j.jad.2025.03.174","DOIUrl":"10.1016/j.jad.2025.03.174","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a serious mental and psychological problem among elderly people. This study aimed to explore the association between social cognition, depressive symptoms and resilience among elderly people living in communities.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted in China from January 2022 to August 2024. A total of 1958 participants aged 60 years or older were selected using a complex multistage sampling design from 39 locations. Data were collected through face-to-face interviews. Social cognition was measured using six items from the Blessed Dementia Rating Scale and the short form Chinese Geriatric Depression Scale was used to measure depressive symptoms. Logistic regression models were used to assess the association between social cognition and depressive symptoms.</div></div><div><h3>Results</h3><div>Univariate analysis results showed that the prevalence of depressive symptoms were high in group with low levels of social cognition function and in group with low levels of general cognition function. Logistic regression analysis results showed that depressive symptoms were negatively associated with social cognition and general cognition levels adjusted for covariates, and the odds ratios were 0.29 and 0.46 (<em>P</em> &lt; 0.001), respectively.</div></div><div><h3>Limitations</h3><div>This was a cross-sectional study and conducted a post-hoc analysis that could not determine the causal association between social cognition and increased prevalence of depressive symptoms.</div></div><div><h3>Conclusion</h3><div>Social cognition function was more strongly associated with depressive symptoms compared with general cognition function among elderly people. These results suggest that the prevalence of depressive symptoms may be directly or indirectly decreased by improving the social cognition level among elderly people.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 584-590"},"PeriodicalIF":4.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of psychotherapeutic interventions for prolonged grief disorder: A systematic review","authors":"Tara Srivastava ,&nbsp;Keegan Lee ,&nbsp;Rebecca Ehrenkranz ,&nbsp;Philip Cozzolino ,&nbsp;Fatma A. Wise ,&nbsp;Madeline Burns ,&nbsp;Tess McCormick ,&nbsp;David Yaden ,&nbsp;Manish Agrawal ,&nbsp;J. Kim Penberthy","doi":"10.1016/j.jad.2025.03.173","DOIUrl":"10.1016/j.jad.2025.03.173","url":null,"abstract":"<div><div>Prolonged Grief Disorder (PGD), newly recognized in the ICD-11 and DSM-5-TR, represents a severe and persistent bereavement response that disrupts adaptive functioning. Characterized by intense yearning, preoccupation with the deceased, and profound social and emotional disturbances, PGD is associated with adverse physical and mental health outcomes. While most individuals progress from acute to integrated grief, those with PGD remain entrenched in maladaptive grief patterns. With prevalence estimates ranging from 9.8 % to 34.3 % in bereaved populations, especially following traumatic or sudden losses, the need for effective interventions is urgent.</div><div>This systematic review examines the efficacy of psychotherapeutic interventions for PGD across 30 randomized controlled trials published between 2011 and 2024. Cognitive Behavioral Therapy (CBT) emerged as the predominant and most effective approach, demonstrating versatility across individual, group, and internet-based formats. Innovations such as combining CBT with mindfulness, exposure therapy, or EMDR showed promise, particularly in addressing trauma-related grief. Alternative interventions, including music therapy and Accelerated Resolution Therapy, revealed potential benefits but require further investigation. Mindfulness-based therapies, while less prevalent, showed modest efficacy when integrated with CBT frameworks.</div><div>Findings emphasize the need for personalized, culturally sensitive treatments tailored to the diverse circumstances of grief. The success of internet-delivered interventions highlights opportunities to expand access, particularly in resource-limited settings. Despite progress, gaps remain in understanding the role of pharmacological adjuncts, long-term outcomes, and underrepresented populations.</div><div>This review underscores the importance of advancing therapeutic approaches to mitigate PGD's profound impact on individuals and communities, proposing directions for future research and clinical practice.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 561-575"},"PeriodicalIF":4.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Altered electroencephalography-based source functional connectivity in drug-free patients with major depressive disorder” [Journal of Affective Disorders 369 (2025) 1161-1167/JAD_18460]","authors":"Che-Sheng Chu ,&nbsp;Yen-Yue Lin ,&nbsp;Cathy Chia-Yu Huang ,&nbsp;Yong-An Chung ,&nbsp;Sonya Youngju Park ,&nbsp;Wei-Chou Chang ,&nbsp;Chuan-Chia Chang ,&nbsp;Hsin-An Chang","doi":"10.1016/j.jad.2025.03.144","DOIUrl":"10.1016/j.jad.2025.03.144","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Page 474"},"PeriodicalIF":4.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sedentary time with school bullying among adolescents in 74 countries: A population-based study","authors":"Yongliang Zhu ,&nbsp;Fei Li ,&nbsp;Danyi Huang ,&nbsp;Liuqing Li ,&nbsp;Mengna Pan ,&nbsp;Qiuju Li ,&nbsp;Jiahong Sun ,&nbsp;Chuanwei Ma","doi":"10.1016/j.jad.2025.03.176","DOIUrl":"10.1016/j.jad.2025.03.176","url":null,"abstract":"<div><h3>Background</h3><div>Numerous studies have demonstrated the association between sedentary behavior and bullying among adolescents. However, few have explored the “dose-response” relationship between the frequency of sedentary behavior and school bullying. We aimed to evaluate the “dose-response” relationship between leisure sedentary time and school bullying among adolescents.</div></div><div><h3>Methods</h3><div>We used data from the most recent Global School-based Student Health Survey (GSHS), conducted between 2009 and 2019 from 74 countries. Multivariable logistic regression analysis was employed to investigate the association between leisure sedentary time and school bullying.</div></div><div><h3>Results</h3><div>A total of 222,172 adolescents aged 12–17 years from 74 countries were included. Overall, 29.8 % of adolescents reported having sedentary time ≥ 3 h/d, and 14.9 % reported experiencing school bullying. Compared with sedentary time &lt; 1 h/d, increased sedentary time (except for 1–2 h/d: OR = 1.02, 95 % CI = 0.83–1.24) were associated with school bullying (3–4 h/d: OR = 1.16, 95 % CI = 1.01–1.34; ≥5 h/d: OR = 1.40, 95 % CI = 1.23–1.58).</div></div><div><h3>Limitations</h3><div>The data assessing school bullying and sedentary time were derived from self-reported survey questionnaires, potentially introducing recall bias.</div></div><div><h3>Conclusions</h3><div>School bullying is still widespread globally, and is associated with an extended period of leisure sedentary time. Efforts to reduce sedentary behavior among adolescents may potentially make a substantial impact on reducing the incidence of school bullying.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 591-597"},"PeriodicalIF":4.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of six antidepressants on electrolytes, hepatic and renal function, and glycolipid metabolism in patients with major depressive disorder.","authors":"Lingjun Zhong, Yingying Yue, Xiaoyun Liu, Hualing Chen, Yongkang Qian, Wei Tang, Bingwei Chen, Yonggui Yuan, Hua Shao","doi":"10.1016/j.jad.2025.03.172","DOIUrl":"https://doi.org/10.1016/j.jad.2025.03.172","url":null,"abstract":"<p><strong>Background: </strong>Most antidepressants with similar pharmacological characteristics exhibit comparable therapeutic efficacy but differ in side effects. Therefore, we used a retrospective design to compare biochemical changes induced by six antidepressants and identify differences among them.</p><p><strong>Methods: </strong>Case records from 1706 hospitalized patients with major depressive disorder (MDD) receiving antidepressant monotherapy were divided into six groups based on the specific antidepressants used: paroxetine, sertraline, fluoxetine, escitalopram, venlafaxine, and duloxetine. Electrolytes, hepatic and renal function, body weight, and glycolipid metabolism were assessed at baseline and 2 weeks post-antidepressant initiation. Paired analysis was used for comparing the changes prior to and after administration within each group, and analysis of covariance was used for evaluating the distinctions among the six groups.</p><p><strong>Results: </strong>After 2 weeks of treatment, significant decreases in serum sodium and chloride levels were observed with venlafaxine, duloxetine, and fluoxetine, while potassium, phosphorus, and carbon dioxide concentrations tended to increase across all six antidepressants. In terms of hepatic indicators, these antidepressants significantly elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transpeptidase (GGT) levels, with duloxetine showing the most pronounced changes from baseline, while decreasing total and direct bilirubin. Sertraline effectively reduced uric acid, although changes in renal indicators were mild with other antidepressants. Notably, these antidepressants were associated with an unfavorable lipid profile, particularly elevated triglycerides and cholesterol, but they lowered blood glucose during the acute phase.</p><p><strong>Limitation: </strong>Residual confounding may indirectly influence the retrospective outcomes.</p><p><strong>Conclusion: </strong>Early biochemical changes can distinguish differences among antidepressants and guide individualized medication.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperforin-induced gut microbiota metabolite carbocysteine protects against depressive-like behaviors in mice by modulating the colonic mucus barrier","authors":"Zheng Zhang ,&nbsp;Bo Xing ,&nbsp;Xuhui Liu ,&nbsp;Kaixuan Shi ,&nbsp;Qingjie Chen","doi":"10.1016/j.jad.2025.03.164","DOIUrl":"10.1016/j.jad.2025.03.164","url":null,"abstract":"<div><h3>Objective</h3><div>Depression affects millions, and current treatments have limitations, necessitating new approaches. Earlier research confirms Hyperforin's ability to reduce anhedonic behaviors in mice and modulate gut microbiota. This study aims to identify specific metabolic changes induced by Hyperforin that could illuminate its impact on gut microbiome metabolism, possibly uncovering novel metabolites for developing antidepressant therapies.</div></div><div><h3>Methods</h3><div>Following the chronic stress model, untargeted metabolomic analysis of fecal samples was conducted to identify metabolic changes induced by Hyperforin. Bioinformatics tools analyzed the origins of differentially expressed metabolites and their correlation with <em>Akkermansia muciniphila</em> and Muribaculum intestinale. The significant metabolite Carbocysteine was further investigated for its antidepressant effects using behavioral assays in a mouse model of depression. Additionally, the response of the colonic mucus barrier was evaluated using Periodic Acid-Schiff (PAS) staining, scanning electron microscopy (SEM), and enzyme-linked immunosorbent assays (ELISA).</div></div><div><h3>Results</h3><div>Hyperforin significantly altered fecal metabolite profiles in stressed mice, with a notable shift in 239 metabolites mainly associated with co-metabolism pathways and microbiota-specific processes. Among these, Carbocysteine emerged as a key metabolite linked to beneficial bacteria <em>Akkermansia muciniphila</em> and Muribaculum intestinale, with its levels significantly elevated following Hyperforin treatment. Behavioral assessments indicated that Carbocysteine supplementation ameliorated depressive-like behaviors in the chronic restraint stress mouse model. It also enhanced colonic mucus production and integrity.</div></div><div><h3>Conclusion</h3><div>Our research highlights Hyperforin's role in modulating gut microbiota metabolism and identifies Carbocysteine as a potential antidepressant. These findings advance our understanding of the gut-brain axis (GBA) in depression and pave the way for developing new therapeutics.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 620-630"},"PeriodicalIF":4.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}