Journal of affective disorders最新文献

{"title":"Exploring digital health tools for depression management in primary health care: Systematic review and meta-analysis","authors":"Aïna Fuster-Casanovas ,&nbsp;Sonia Moretó Melero ,&nbsp;Daniela Cabutto ,&nbsp;Carme Carrion ,&nbsp;Josep Vidal-Alaball ,&nbsp;Estefania Herrera-Ramos ,&nbsp;Carles Barcons ,&nbsp;Andrea Duarte-Díaz","doi":"10.1016/j.jad.2025.03.187","DOIUrl":"10.1016/j.jad.2025.03.187","url":null,"abstract":"<div><h3>Background</h3><div>Digital health tools are transforming mental health care, particularly in treating depression, which affects 5 % of the global population and is projected to be the top disease burden by 2030. In primary care, these tools improve accessibility and efficacy, addressing rising mental health demands, especially post-COVID-19.</div></div><div><h3>Objective</h3><div>The aim of this study is to assess the efficacy of digital health tools for the management of depression within primary care.</div></div><div><h3>Methods</h3><div>A systematic review followed PRISMA guidelines, focusing on digital health tools for reducing depressive symptoms. Controlled trials were included, with RCTs assessed via the Cochrane risk-of-bias tool and non-RCTs evaluated using the JBI checklist for quasi-experimental studies. Depressive symptom reduction was the primary outcome.</div></div><div><h3>Results</h3><div>A total of 29 controlled trials met the inclusion criteria, identifying were web-based platforms, mobile apps, phone calls, text messages, and decision algorithms. The meta-analysis revealed that digital health tools had a significant effect on depressive symptoms (<em>g</em> = −0.22, 95 % CI: −0.37; −0.06, I² = 79.64 %). At 6 to 12-month follow-up, the random effects meta-analysis showed that digital health tools had a significant effect on depressive symptoms (<em>g</em> = −0.19, 95%CI: −0.29; −0.09, I² = 53.42 %).</div></div><div><h3>Conclusions</h3><div>Digital health tools are effective in reducing the symptoms of repression. Symptom severity does not predict suitability for digital treatment, emphasizing the need for gender-sensitive approaches and strategies for older adults. Integrating digital interventions into clinical guidelines requires studies like this to support their adoption in real-world practice.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 494-506"},"PeriodicalIF":4.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and feasibility of the oxford mental illness suicide tool (OxMIS): A mini-review and meta-analysis","authors":"Gabriele Torino ,&nbsp;Chiara Moltrasio ,&nbsp;Antonio Callari ,&nbsp;Giuseppe Delvecchio","doi":"10.1016/j.jad.2025.04.052","DOIUrl":"10.1016/j.jad.2025.04.052","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with severe mental illness are at a greater risk of suicide than the general population. Therefore, a concerted effort has been made to create increasingly precise and reliable tools over the last decade. Among these tools, in 2019 the Oxford Mental Illness and Suicide Tool (OxMIS) was developed to estimate the probability of suicide risk within 12 months for individuals diagnosed with bipolar disorder or schizophrenia spectrum disorder. Therefore, in this review, we aimed to synthesise the peer-reviewed literature collected on the OxMIS tool.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted using the databases PubMed, PsycINFO, Scopus, and Web of Science, resulting in the identification of 129 records. After removing duplicates and conducting an in-depth review of the full texts, 5 articles were included in the mini-review. Additionally, a fixed-effects model was employed to calculate the pooled effect size from 2 studies using Comprehensive Meta-Analysis (CMA) 3.7 software.</div></div><div><h3>Results</h3><div>The OxMIS tool was found to be clinically feasible and to lead to an average cost-saving of approximately £300 per assessed patient as well as a marginal improvement in quality-adjusted life years. Furthermore, the OxMIS tool achieved good discrimination accuracy in terms of sensitivity and specificity in a Swedish and Finnish validation sample. The overall pooled odd ratio (OR) was 3.416 [95 % CI: 3.092–3.774].</div></div><div><h3>Limitations</h3><div>The first limitation pertains to the scarcity of studies on OxMIS, which necessitates a degree of caution in interpreting the results. Moreover, although the reviewed studies analyzed different aspects of the use of OxMIS, the differences in objectives and research designs limited a comprehensive comparison of the results between the included studies. Finally, the discrepancy in the prevalence of high suicide risk among patients of different study populations requires further investigation in future studies.</div></div><div><h3>Conclusion</h3><div>From the reviewed studies emerged that OxMIS is a novel and promising web-based tool that is capable of estimating the suicide risk of patients with serious mental illnesses. Nevertheless, further external validation studies are required to confirm its clinical utility across different study populations.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 321-328"},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of PTSD-depression comorbidity in long-term mental health sequalae of the October 7th terror attack in Israel: A nationwide prospective study","authors":"Yossi Levi-Belz ,&nbsp;Doron Amsalem ,&nbsp;Yoav Groweiss ,&nbsp;Carmel Blank ,&nbsp;Yuval Neria","doi":"10.1016/j.jad.2025.04.049","DOIUrl":"10.1016/j.jad.2025.04.049","url":null,"abstract":"<div><h3>Introduction</h3><div>The October 7, 2023, attack engendered extensive mental pain and can be considered a mass trauma that affected most Israeli citizens. This study investigates the long-term psychological impact of probable posttraumatic stress disorder and major depressive disorder (PTSD-MDD) one month after October 7th, on anxiety, depression, PTSD, and complex PTSD (CPTSD) symptoms as well as on suicidal ideation, and life satisfaction one-year post-attack among Israeli civilians.</div></div><div><h3>Methods</h3><div>Using a nationally representative cohort of 600 participants (302 women, 50.3 %) aged 18–85 (<em>M</em>_age = 41.02, <em>SD</em> = 13.79), data were collected two months pre-attack (T1), one-month post-attack (T2), and one-year post-attack (T3). Using validated self-report measures, probable diagnostic groups at T2 (no diagnosis, PTSD alone, depression alone, and probable PTSD-MDD comorbidity) were examined as predictors of mental health outcomes at T3, including anxiety, depression, PTSS, CPTSD, suicidal ideation, and life satisfaction. Baseline symptom levels (T1) as well as demographics and trauma-related variables were controlled during the analyses.</div></div><div><h3>Results</h3><div>Probable PTSD-MDD at T2 significantly predicted severe psychological outcomes at T3, including anxiety, depression, PTSS, and suicidal ideation. Life satisfaction was lowest among probable PTSD-MDD participants and highest in those without diagnoses. Notably, probable PTSD-MDD demonstrated greater stability over time compared to single diagnoses, underscoring their persistence. Changes in probable diagnostic categories between T2 and T3 highlighted the dynamic yet challenging recovery trajectories particularly for comorbid conditions.</div></div><div><h3>Discussion</h3><div>The findings underscore the amplifying effect of probable PTSD-MDD comorbidity on psychological distress and reduced life satisfaction. These results underscore the need for integrative, trauma-informed interventions targeting comorbid populations to optimize recovery pathways.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 410-417"},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined ketamine and psychotherapy provide no additional benefit beyond ketamine alone in treating depression or PTSD: Evidence from a help-seeking sample","authors":"Tyler M. Moore ,&nbsp;Kathryn Walker ,&nbsp;Emma Tung ,&nbsp;Adam R. Teed ,&nbsp;Franz Hell ,&nbsp;Sivan Kinreich ,&nbsp;Rex Jung ,&nbsp;Fadi Abdel ,&nbsp;Russell W. Hanson ,&nbsp;Shobi S. Ahmed","doi":"10.1016/j.jad.2025.04.041","DOIUrl":"10.1016/j.jad.2025.04.041","url":null,"abstract":"<div><div>Depression and PTSD are prevalent psychiatric conditions that often co-occur and significantly impact quality of life. Ketamine has emerged as a promising rapid-acting treatment for both conditions, while traditional treatments like psychotherapy typically require weeks to show effects. This study investigated whether combining ketamine with psychotherapy produces greater symptom improvement compared to ketamine alone. We analyzed overlapping samples of <em>N</em> = 202, <em>N</em> = 470, and <em>N</em> = 624 help-seeking individuals (all samples ∼60 % female, mean age ∼ 42 years) who received either ketamine alone (KET) or ketamine plus psychotherapy (KET+PSY) across 4–14 treatment sessions within a 30- or 180-day period. Depression symptoms were measured using the PHQ-9, and PTSD symptoms were assessed using the PCL-5. Trajectories of symptom change were analyzed using generalized additive mixed-effects models, controlling for baseline symptoms, demographics, and treatment intervals. Both treatment groups showed substantial improvement in depression and PTSD symptoms, with similar patterns of rapid initial decline followed by stabilization. Contrary to our hypothesis, we found no significant differences in symptom trajectories between the KET and KET+PSY groups. Exploratory analyses revealed non-significant but notable patterns where younger females showed better outcomes with combined treatment, while older males showed better outcomes with ketamine alone. These findings suggest that ketamine's therapeutic effects may be robust enough that additional psychotherapy during the acute treatment phase does not significantly enhance 30-day (and possibly 180-day) outcomes. However, longer-term benefits of combined treatment and potential demographic-specific treatment responses warrant further investigation. These results have important implications for treatment planning and resource allocation in clinical settings.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 233-241"},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cingulate cortex cortical thickness associated with non-suicidal self-injury and suicide risk in youth with mood disorders","authors":"Rebekah S. Huber ,&nbsp;Punitha Subramaniam ,&nbsp;Lauren Heinrich ,&nbsp;Danielle J. Boxer ,&nbsp;Xianfeng Shi ,&nbsp;Mindy Westlund Schreiner ,&nbsp;Perry F. Renshaw ,&nbsp;Deborah A. Yurgelun-Todd ,&nbsp;Douglas G. Kondo","doi":"10.1016/j.jad.2025.04.047","DOIUrl":"10.1016/j.jad.2025.04.047","url":null,"abstract":"<div><h3>Background</h3><div>Non-suicidal self-injury (NSSI) is associated with increased suicide risk and is prevalent among patients with mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). Structural alterations in cortical regions involved in emotional processing are linked to NSSI as well as suicide risk in mood disorders. Few studies have investigated the neurobiological substrates of NSSI and suicidal thoughts and behaviors (STB), particularly comparing youth with BD to those with MDD. There is a critical need to examine NSSI and STB in the context of MDD and BD separately, as risks differ between these populations.</div></div><div><h3>Methods</h3><div>This study investigated the relationship between anterior cingulate cortex (ACC) cortical thickness and volume and NSSI and STB in youth with mood disorders. One-hundred thirty-seven youth (86 with MDD and 51 with BD), ages 13 to 21, completed a diagnostic interview, clinical assessments, and 3 T magnetic resonance imaging. Morphometric analysis of brain images was performed to evaluate differences in cingulate regions of interest.</div></div><div><h3>Results</h3><div>Seventy-five youth reported a NSSI. Youth with BD were more likely to report NSSI than youth with MDD. In addition, youth with BD and NSSI were more likely to have a suicide attempt and had significantly lower cortical thickness in the right caudal ACC (<em>p</em> = .009, η² = 0.050) compared to youth with MDD and NSSI.</div></div><div><h3>Conclusions</h3><div>These structural alterations in the ACC, which impact emotional regulation and pain processing, may be linked to the increased NSSI and suicide risk observed in BD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged social withdrawal (“hikikomori”) and its associations with depressive symptoms and suicidal ideation among young adults in Korea: Findings from the 2022 Youth Life Survey","authors":"Seong-Uk Baek ,&nbsp;Jin-Ha Yoon","doi":"10.1016/j.jad.2025.04.044","DOIUrl":"10.1016/j.jad.2025.04.044","url":null,"abstract":"<div><h3>Background</h3><div>Hikikomori syndrome (HS) is a public health concern. We investigated the prevalence of HS and its association with depressive symptoms and suicidal ideation among young Korean adults.</div></div><div><h3>Methods</h3><div>Young adults aged 19–34 years was obtained from the 2022 Youth Life Survey, with a total of 14,870 participants. HS was defined as a condition characterized by ≥six months of social withdrawal, including lack of employment or school engagement, lack of social interaction, and confinement to one's home or room, which causes distress to the individual or impairs social functioning. Depressive symptoms were assessed using the Patient Health Questionnaire-9. The presence of suicidal ideation within the past year was evaluated. Logistic regression was performed to calculate odds ratios (ORs) and 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>The prevalence of HS in the sample was 1.4 % (<em>n</em> = 871). Individuals with HS exhibited a higher prevalence of both depressive symptoms (20.9 % vs. 5.9 %) and suicidal ideation (11.0 % vs. 2.3 %) compared to those without HS. The OR (95 % CI) of the association between HS and depressive symptoms was 3.91 (2.47–6.18) compared with non-HS after adjusting for sociodemographic features. Similarly, the adjusted OR (95 % CI) of the association between HS and suicidal ideation was 5.24 (2.88–9.52) compared with non-HS. A further analysis indicated that depressive symptoms partially mediates the association between HS and suicidal ideation.</div></div><div><h3>Limitation</h3><div>The cross-sectional study design limits the ability to infer causality.</div></div><div><h3>Conclusion</h3><div>HS was linked to poor mental health. Policy efforts aimed at identifying young adults with HS and protecting their mental health are required.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights and recommendations for research on predicting non suicidal self-injury among depressive Chinese adolescents.","authors":"Jialao Ma, Pincheng Luo, Sijia Liu","doi":"10.1016/j.jad.2025.04.037","DOIUrl":"https://doi.org/10.1016/j.jad.2025.04.037","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal association between stigma and suicidal ideation among patients with major depressive disorder","authors":"Yanzhi Li ,&nbsp;Yan Chen ,&nbsp;Yifeng Liu ,&nbsp;Yingchen Jiang ,&nbsp;Hao Zhao ,&nbsp;Wanxin Wang ,&nbsp;Yuhua Liao ,&nbsp;Huimin Zhang ,&nbsp;Lan Guo ,&nbsp;Beifang Fan ,&nbsp;Angela T.H. Kwan ,&nbsp;Roger S. McIntyre ,&nbsp;Ciyong Lu ,&nbsp;Xue Han","doi":"10.1016/j.jad.2025.04.036","DOIUrl":"10.1016/j.jad.2025.04.036","url":null,"abstract":"<div><h3>Background</h3><div>To explore the longitudinal associations between stigma and suicidal ideation among patients with major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>Data were from patients with MDD in the Depression Cohort in China. At baseline and weeks 4, 8, 12, 24, 48, and 72, the presence (yes and no) and severity (scores) of suicidal ideation were evaluated using the Beck Scale for Suicide Ideation, and stigma was assessed using the Depression Stigma Scale. Generalized linear mixed models were used to explore the association between stigma and suicidal ideation.</div></div><div><h3>Results</h3><div>Among 1123 patients with a mean age of 27.9 (SD, 7.3) years, 71.1 % were female. Restricted cubic splines showed positive linear dose-response associations of personal stigma and perceived stigma with the likelihood and severity of suicidal ideation. The adjusted ORs (95 % CIs) for each 10 score increment in personal stigma and perceived stigma were 1.49 (1.18, 1.89) and 1.46 (1.20, 1.77) for the likelihood of suicidal ideation, respectively. The adjusted <em>β</em> coefficients (95 % CIs) for each 10 score increment in personal stigma and perceived stigma were 0.222 (0.121, 0.322) and 0.202 (0.123, 0.281) for suicidal ideation scores, respectively.</div></div><div><h3>Limitations</h3><div>Information on sigma, suicidal ideation, and potential covariates was self-reported, so reporting bias was inevitable.</div></div><div><h3>Conclusions</h3><div>In this longitudinal study in patients with MDD, more severe personal stigma and perceived stigma were associated with a higher likelihood of suicidal ideation and more severe suicidal ideation. These findings suggest that reducing personal stigma and perceived stigma may help prevent suicidal behavior among patients with MDD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare and psychiatric drug utilization after a suicide attempt in patients with depression: a register-based Swedish cohort study","authors":"Viktoria Johansson ,&nbsp;Philip Brenner ,&nbsp;Pär Karlsson ,&nbsp;Adina L. Feldman ,&nbsp;Johan Reutfors","doi":"10.1016/j.jad.2025.04.034","DOIUrl":"10.1016/j.jad.2025.04.034","url":null,"abstract":"<div><h3>Background</h3><div>Suicide attempts (SA) are common in depression, yet little is known about healthcare utilization (HCU) and psychiatric drug utilization (PDU) following a SA. This study assesses and compares HCU and PDU patterns in patients with depression with and without a SA.</div></div><div><h3>Methods</h3><div>We retrieved data from population-based registers on 359,276 patients with incident depression. Patients with a first-time SA (<em>n</em> = 16,748), were matched with comparators (<em>n</em> = 330,764). Patients with a history of SA (<em>n</em> = 11,764) were analyzed separately. Inpatient days, outpatient visits, and the amount of psychiatric medications were measured until five years after the SA.</div></div><div><h3>Results</h3><div>Patients with a first-time SA had four times higher psychiatric inpatient HCU (ratio 3.8 [95 % CI 3.6–4.0]) and twice higher outpatient HCU (ratio 1.7 [95 % CI 1.7–1.8]) than comparators in the year following the SA. PDU was higher for most drug classes in the SA patients, with the largest difference observed for anxiolytics and sedatives (ratio 1.9 [95 % CI 1.8–1.9]). Higher HCU and PDU in SA patients persisted throughout the five-year follow-up period.</div></div><div><h3>Limitations</h3><div>Our data did not include depressed patients from primary care, indicating that the findings may be more generalizable to patients with moderate or severe depression.</div></div><div><h3>Conclusions</h3><div>Patients with depression who attempted suicide had higher HCU and PDU than comparators during the five-year follow-up period. The association between SA and increased HCU and PDU underscores the ongoing suffering of these individuals as well as the substantial burden placed on the healthcare system.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 484-493"},"PeriodicalIF":4.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal association between consecutive moderate-to-vigorous physical activity and the risk of depression among depressed and non-depressed participants: A nationally representative cohort study","authors":"Yohwan Lim","doi":"10.1016/j.jad.2025.03.048","DOIUrl":"10.1016/j.jad.2025.03.048","url":null,"abstract":"<div><div>The association between moderate-to-vigorous physical activity (MVPA) with depression are clear but needs to be investigated considering dynamic changes in MVPA. We investigated the association of longitudinal changes in MVPA with depression-related outcomes among depressed and non-depressed participants. From 209,095 depressed and 3,777,173 non-depressed participants of South Korea, MVPA was assessed from health screenings during period 1 (2014–15) and 2 (2016–17) using self-reported questionnaires. Participants were followed up from January 1, 2018 to 1-year and 3-year for any diagnosis of depression. Adjusted odds ratio (aOR) and 95 % confidence interval (CI) were calculated using multivariable-adjusted logistic regression analysis. From depressed participants, consistently highly active participants showed the lowest odds for incident depression (aOR 0.81; 95 % CI 0.70–0.95), while those who increased MVPA showed the lowest odds for depressive symptom (aOR 0.77; 95 % CI 0.72–0.82). When combining MVPA status during period 0 (2012−13) for the longitudinal analysis, the participant with depression at period 1 showed a lower odds if they maintained to be physically active before and after depression diagnosis (from period 0 to period 2). We found epidemiologic evidence that longitudinal evaluation for MVPA from pre-depression state may be important on analyzing depression-related risk.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 475-483"},"PeriodicalIF":4.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}