Journal of affective disorders最新文献

{"title":"Comparison of depressive and anxiety symptom networks in maltreated and non-maltreated adolescents","authors":"Xinger Li ,&nbsp;Xiuqiong Feng ,&nbsp;Lu Li ,&nbsp;Shengyu Luo ,&nbsp;Wanting Hu ,&nbsp;Dan Xu ,&nbsp;Jinghua Li ,&nbsp;Weiqing Chen ,&nbsp;Vivian Yawei Guo","doi":"10.1016/j.jad.2025.119786","DOIUrl":"10.1016/j.jad.2025.119786","url":null,"abstract":"<div><h3>Background</h3><div>Maltreatment is a well-established risk factor for both depressive and anxiety symptoms. However, the symptom-level associations between these mental health issues in adolescents with and without a history of maltreatment remain underexplored. This study employed network analysis to compare depressive and anxiety symptom networks across these two groups.</div></div><div><h3>Methods</h3><div>This cross-sectional study involved 6618 Chinese adolescents. The Childhood Trauma Questionnaire-Short Form was used to assess maltreatment, while the 9-item Patient Health Questionnaire and the 7-item Generalized Anxiety Disorder scale were used to measure depressive and anxiety symptoms, respectively. Network analyses were conducted separately for adolescents with and without maltreatment, and compared using network comparison tests.</div></div><div><h3>Results</h3><div>Of the adolescents included (mean age [standard deviation]: 14.5 [1.6] years; 52.2 % boys), 63.8 % reported experiencing maltreatment. Maltreated adolescents had more severe depressive and anxiety symptoms than their non-maltreated peers. Network analysis identified “Uncontrollable worry”, “Excessive worry”, and “Trouble relaxing” as central symptoms in both groups. “Irritability” emerged as the key bridge symptom in the maltreatment group, whereas it was “Nervousness” in non-maltreatment group. The maltreatment group exhibited stronger network connections and significantly different network structure compared to the non-maltreatment group. “Suicidal ideation” had higher expected influence and three stronger edges in the maltreatment group.</div></div><div><h3>Conclusion</h3><div>Both overlapping and distinct central and bridge symptoms were identified across the two groups, with “Suicidal ideation” requiring particular attention in the maltreatment group. These findings highlight the importance of interventions that address shared symptom patterns across adolescents, while incorporating tailored components for those with maltreatment experiences.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119786"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal-maternal congruence in emotional abuse and adolescent depressive symptoms: A moderated polynomial regression with response surface analyses","authors":"Sen Li ,&nbsp;Limeng Shang ,&nbsp;Ningning Gong ,&nbsp;Licun Zhang","doi":"10.1016/j.jad.2025.119799","DOIUrl":"10.1016/j.jad.2025.119799","url":null,"abstract":"<div><h3>Background</h3><div>Adolescent depressive symptoms are a significant concern around the world. Existing research has found that parental emotional abuse is an important risk factor for adolescent depressive symptoms. However, these studies typically treated parental emotional abuse as a whole, without distinguishing differential effects of paternal and maternal emotional abuse. Thus, this conceptual and empirical work was designed to explore the unique and joint effects of paternal and maternal emotional abuse on adolescent depressive symptoms. Moreover, we further explored whether this relation could be moderated by social support.</div></div><div><h3>Methods</h3><div>Participants were 1639 Chinese adolescents (52.50 % girls, <em>M</em>_age = 14.49, <em>SD</em> = 1.11 at baseline). They completed questionnaires regarding demographics, paternal and maternal emotional abuse, social support, and internalizing problems at Time 1. After 7 months, they finished the measure of depressive symptoms at Time 2.</div></div><div><h3>Results</h3><div>Results showed that paternal emotional abuse and maternal emotional abuse were both positively and significantly associated with adolescent depressive symptoms. Additionally, when paternal and maternal emotional abuse were congruent, the link between high parental emotional abuse and adolescent depressive symptoms was stronger than that between low parental emotional abuse and adolescent depressive symptoms. Compared to extreme levels of emotional abuse, moderate levels of emotional abuse were most strongly related to adolescent depressive symptoms. When paternal and maternal emotional abuse were incongruent, compared to low paternal-high maternal emotional abuse, the link between high paternal-low maternal emotional abuse and adolescent depressive symptoms was significantly stronger. Adolescent depressive symptoms increased with the growing discrepancy in parental emotional abuse. Additionally, social support moderated the congruent and incongruent effects of paternal-maternal emotional abuse on adolescent depressive symptoms.</div></div><div><h3>Conclusion</h3><div>Parental congruence and incongruence in emotional abuse are risk factors for adolescent depressive symptoms, and social support plays a moderating role in this relation.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119799"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive network analysis of biopsychosocial factors associated with postpartum depression","authors":"Kristof Hoorelbeke ,&nbsp;Eiko I. Fried ,&nbsp;Ernst H.W. Koster","doi":"10.1016/j.jad.2025.119808","DOIUrl":"10.1016/j.jad.2025.119808","url":null,"abstract":"<div><h3>Background</h3><div>This study investigated relations between a broad set of postpartum depression (PPD) risk- and protective factors, their centrality and unique relations with PPD symptoms.</div></div><div><h3>Methods</h3><div>Mixed graphical network models were estimated in cross-sectional data collected during Phase 7 (2012–2015) of the Pregnancy Risk Assessment Monitoring System. Women were contacted two to six months following birth. Half of the 57,518 women were included in exploratory model 1, the other half in model 2 for cross-validation. A broad selection of biopsychosocial factors were modelled, including sociodemographic variables, indices of maternal health (behavior), pregnancy course, support, infant variables, and stressors.</div></div><div><h3>Results</h3><div>A densely connected network of risk- and protective factors was obtained. Pregnancy duration, infant intensive care unit placement, infertility treatment, birth weight, income, and childbirth classes were ranked among the most central variables in the model. Out of 35 biopsychosocial factors included in the model, 11 were robustly related with PPD across both samples. High income, pre-pregnancy physical activity, pregnancy intention, and prenatal care focusing on depression risk were related to lower depression severity. Several other variables, including prior history of depression, pre-pregnancy dieting, prenatal risk behavior, and personal stressors were uniquely related to increased depression severity. Depressive complaints reduced with increased time since delivery. Women experiencing depressive symptoms were more likely to rely on aid from health workers postpartum. Results from models 1 and 2 were largely identical.</div></div><div><h3>Conclusions</h3><div>Although cross-sectional in nature, these findings shed light on the complex associations between key risk- and protective factors for PPD, with implications for early detection and prevention.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119808"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with subjective well-being of Chinese older adults with cardiovascular diseases based on the health ecological model","authors":"Suyan Wang ,&nbsp;Mengjie Cui ,&nbsp;Guizhi Jia","doi":"10.1016/j.jad.2025.119810","DOIUrl":"10.1016/j.jad.2025.119810","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to analyze key predictors of subjective well-being (SWB), an important psychological indicator reflecting quality of life, of the elderly with cardiovascular diseases (CVDs) in China using a representative nationwide sample.</div></div><div><h3>Methods</h3><div>The data were taken from the China Health and Retirement Longitudinal Study (CHARLS) 2018, and candidate predictors were determined based on the health ecological model (HEM).Chi-square test, <em>t</em>-test, and binary logistic regression was used to investigate the predictors of SWB of the participants from the personal, behavioral, interpersonal, life and work-related, and policy aspects. Finally, the random forest model (RFM) was used to determine the relative importance of the predictors.</div></div><div><h3>Results</h3><div>The participants' SWB were negatively associated with age (OR = 0.986, <em>P</em> = 0.024), actual sleep average hours for one night (OR = 0.946, <em>P</em> = 0.003), average minutes take a nap after lunch (OR = 0.998, <em>P</em> = 0.015), higher education (OR ranges: 0.220–0.319, <em>P</em> range: 0.005–0.040) compared with elementary school and below; The participants' SWB were positively associated with being ethnic minority (OR = 1.504, <em>P</em> = 0.003), and number of comorbid conditions (OR = 1.117, <em>P</em> &lt; 0.001). Based on the RFM model, the top six of the predictors were age (230.968), actual sleep average hours for one night (159.951), average minutes take a nap after lunch (138.571), number of comorbid conditions (115.847), education (50.784), and ethnicity (23.575).</div></div><div><h3>Conclusion</h3><div>The top six predictors of SWB of the elderly with CVDs in China were age, actual sleep average hours for one night, average minutes take a nap after lunch, number of comorbid conditions, education, and ethnicity.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119810"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher levels of depression are associated with increased all-cause mortality in individuals with chronic kidney disease: A prospective study based on the NHANES database","authors":"Jingui Zhao ,&nbsp;Mei Wu ,&nbsp;Li Zhang ,&nbsp;Xue Han ,&nbsp;Jianrong Wu ,&nbsp;Chaoban Wang","doi":"10.1016/j.jad.2025.119785","DOIUrl":"10.1016/j.jad.2025.119785","url":null,"abstract":"<div><h3>Background</h3><div>Chronic kidney disease (CKD) is a progressive condition associated with high mortality rates worldwide. Although depression is common in CKD patients, it is rarely addressed in current management guidelines, possibly due to limited long-term data.</div></div><div><h3>Methods</h3><div>We analyzed data from the National Health and Nutrition Examination Survey and the National Death Index from 2005 to 2020. CKD patients with complete data on mortality and covariate data were included. Depression was assessed using the PHQ-9 questionnaire, categorizing participants into four groups: four levels (<em>G1</em> <em>=</em> <em>0</em>, <em>G2</em> <em>=</em> <em>1–3</em>, <em>G3</em> <em>=</em> <em>4–9</em>, <em>G4</em> <em>≥</em> <em>10</em>). A Cox regression model evaluated the relationship between depression levels and all-cause mortality.</div></div><div><h3>Results</h3><div>Among 4438 CKD patients (mean age 58.28 years, 48 % male), and a dose-response relationship was observed, with increasing depression severity associated with progressively higher mortality risk. After adjusting for key prognostic indicators of CKD, the Cox regression model demonstrated that the high depression group (G4) exhibited a significantly higher risk of death compared to the no depression group (G1) (model 3-G4: HR = 1.69 (1.33, 2.14), <em>P</em> &lt; 0.001). Subgroup analyses further revealed consistent trends across demographics.</div></div><div><h3>Conclusion</h3><div>Depression is an independent predictor of increased mortality in CKD patients. Even mild depression can adversely affect survival. Identifying and treating depression in CKD patients may improve prognosis, highlighting the need for further research into this relationship.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119785"},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality modifies and mediates the association between the oxidative balance score and depression: A cross-sectional study of NHANES 2007–2014","authors":"Chen Chen ,&nbsp;Keyu Pan ,&nbsp;Chenzhuo Wu ,&nbsp;Fengyuan Su ,&nbsp;Wei Wang ,&nbsp;Wen-Yang Li","doi":"10.1016/j.jad.2025.119762","DOIUrl":"10.1016/j.jad.2025.119762","url":null,"abstract":"<div><h3>Background</h3><div>Oxidative balance score (OBS) integrates dietary/lifestyle factors influencing oxidative stress. While linked to sleep quality and depression, whether sleep mediates the OBS-depression relationship remains unexplored.</div></div><div><h3>Methods</h3><div>Utilizing NHANES 2007–2014 data (<em>n</em> = 11,383), we calculated OBS from 20 pro−/antioxidant exposures. Sleep metrics included duration, self-reported trouble sleeping, and doctor-told sleep disorder. Depressive symptoms were assessed via PHQ–9. Weighted logistic regression, restricted cubic spline (RCS), and mediation analyses were conducted.</div></div><div><h3>Results</h3><div>The highest OBS quartile associated with reduced depression risk (OR = 0.22, 95%CI = 0.15–0.32), RCS analysis confirmed a non-linear relationship (<em>P</em> for nonlinear = 0.040). Similarly, higher OBS correlated with lower odds of unhealthy sleep patterns (OR = 0.54, 0.42–0.69), sleep disorders (OR = 0.67, 0.47–0.96), trouble sleeping (OR = 0.70, 0.55–0.90), and suboptimal duration (OR = 0.49, 0.38–0.61). There was an interaction between OBS and sleep disorder on depression (<em>P</em> for interaction = 0.039). Progressive depression risk reduction across OBS quartiles occurred in non-sleep-disordered individuals (<em>P</em> for trend&lt;0.001; Q4 vs Q1: OR = 0.24, 0.16–0.36), versus protection limited to Q4 in sleep-disordered group (OR = 0.37, 0.16–0.86; <em>P</em> for trend = 0.059). Mediation analysis indicated partial mediation through sleep pattern (13.1 %), disorders (4.5 %), trouble sleeping (6.3 %), and abnormal duration (8.0 %) between OBS and depression.</div></div><div><h3>Conclusion</h3><div>Sleep quality mediates and modifies OBS-depression associations, with RCS revealing non-linear dynamics. Dual targeting of oxidative balance and sleep improvement may optimize depression prevention.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119762"},"PeriodicalIF":4.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring adolescents' mental health, cyberbullying perpetration, and interpersonal relationships: A latent profile and moderation approach","authors":"Meichen Teng ,&nbsp;Hongyu Zou ,&nbsp;Fang Chen ,&nbsp;Feizhen Cao ,&nbsp;Shuai Chen ,&nbsp;Wei Zhang","doi":"10.1016/j.jad.2025.119782","DOIUrl":"10.1016/j.jad.2025.119782","url":null,"abstract":"<div><h3>Background</h3><div>Mental health and interpersonal relationships are closely linked to cyberbullying among adolescents; however, research examining how these factors interact from an individual-centered perspective remains limited. This study aimed to identify mental health profiles of Chinese adolescents based on the Dual-Factor Model of Mental Health and to explore how these profiles moderate the relationship between interpersonal relationships (parent-child, teacher-student, and peer relationships) and cyberbullying behavior.</div></div><div><h3>Methods</h3><div>The study involved 9612 Chinese adolescents (M_age = 15.73, SD_age = 1.58, 49.02 % girls). Mental health was assessed using 14 indicators (e.g., Patient Health Questionnaire), while interpersonal relationships were measured using the Adolescent Interpersonal Relevance Scale. Cyberbullying perpetration was assessed with the Electronic Bullying Questionnaire (EBQ). Data analysis included latent profile analysis and moderation testing to examine the interactions.</div></div><div><h3>Results</h3><div>The results revealed five distinct mental health profiles among Chinese adolescents. Adolescents with poorer mental health were more likely to engage in cyberbullying. Furthermore, parent-child and peer relationships amplified the risk of cyberbullying among those with lower mental health, while the teacher-student relationship did not significantly moderate this association. Conversely, the teacher-student relationship consistently acted as a protective factor against cyberbullying across all profiles.</div></div><div><h3>Conclusion</h3><div>This study reveal five stable mental health profiles among Chinese adolescents and suggest that the influence of interpersonal relationships on cyberbullying varies according to mental health profiles. Notably, good teacher-student relationships may serve as a key protective factor against cyberbullying, regardless of mental health profile.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119782"},"PeriodicalIF":4.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The causal and mediated relationships between major depressive disorder (MDD), post-traumatic stress disorder (PTSD), anxiety disorders and premature mortality: Evidence from genome-wide association study.","authors":"Chaoran Wu, Shuyan Tong, Yangyang You, Yan Li, Renliang Cai, Jin Fang, Xinyu Fang, Xiangrong Zhang","doi":"10.1016/j.jad.2025.119781","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119781","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have reported that patients with major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and anxiety disorders have significantly higher rates of aging-related illnesses and premature mortality than the general population. However, previous studies have not systematically assessed the possible causal relationship between MDD, PTSD, and anxiety disorders and premature mortality (aging and lifespan) at the genetic level, or searched for possible mediators between them.</p><p><strong>Methods: </strong>Summary-level GWAS data for MDD (N = 480,359), PTSD (N = 206,655), and anxiety disorders (N = 31,060) were all obtained from the Psychiatric Genomics Consortium (PGC). The GWAS data for premature mortality were obtained from two different sources to conduct independent validation of the results: with aging (mvAge, N = 1,958,774) from Zenodo and human lifespan (N = 1,012,240) from Edinbugh DataShare. The summary-level GWAS data of potential mediators were obtained from FinnGen and UK Biobank databases. We first utilized two-sample Mendelian randomization (MR) analysis to evaluate the causal relationship between MDD, PTSD, anxiety disorders and both aging (mvAge) and lifespan. Subsequently, mediation MR analysis was conducted to search for potential mediating factors. Then, we employed linkage disequilibrium score regression (LDSC) to further estimate these genetic correlations based on the initial MR results. Finally, a series of mediation MR analyses were conducted to better understand the relationship between MDD and lifespan.</p><p><strong>Results: </strong>We found that MDD was negatively associated with both mvAge and lifespan in two-sample MR analysis, with consistent results across the two GWAS databases representing premature mortality (mvAge: β (95%CI): -0.064(-0.087-0.041), p < 0.001; human lifespan: β (95%CI): -0.081 (-0.138-0.024), p = 0.005). The causal relationship remained significant after false discovery rate (FDR) correction. The results of LDSC suggested a genetic correlation between MDD, mvAge and lifespan (mvAge: r_g (95%CI): -0.421(-0.479-0.364), p < 0.001; lifespan: r_g (95%CI): -0.175 (-0.238-0.116), p < 0.001). In mediation MR analysis, we found that coronary atherosclerosis, hypertension and major coronary heart disease events were mediators between MDD and lifespan.</p><p><strong>Conclusion: </strong>Our comprehensive findings provide robust genetic evidence that individuals with MDD are at significantly increased risk of premature mortality. This heightened risk is closely associated with a greater susceptibility to coronary atherosclerosis, hypertension, and major coronary heart disease events, which in turn further accentuate their propensity for accelerated aging.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119781"},"PeriodicalIF":4.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms in individuals with overweight and obesity. Results from the LIFE-adult-study","authors":"Franziska Ulrike Jung ,&nbsp;Franziska Bleck ,&nbsp;Alexander Pabst ,&nbsp;Katja Schladitz ,&nbsp;Melanie Luppa ,&nbsp;Felix S. Hussenoeder ,&nbsp;Christoph Engel ,&nbsp;Markus Loeffler ,&nbsp;Andreas Hinz ,&nbsp;Heide Glaesmer ,&nbsp;Nigar Reyes ,&nbsp;Silke Zachariae ,&nbsp;Samira Zeynalova ,&nbsp;Kerstin Wirkner ,&nbsp;Toralf Kirsten ,&nbsp;Arno Villringer ,&nbsp;Steffi G. Riedel-Heller ,&nbsp;Margrit Löbner","doi":"10.1016/j.jad.2025.119792","DOIUrl":"10.1016/j.jad.2025.119792","url":null,"abstract":"<div><h3>Background</h3><div>Prevalences of overweight and obesity are rising worldwide. Comorbidity of depressive symptoms and overweight or obesity are considered as a major public (mental) health issue. The aim was to determine prevalences in a non-treatment seeking population of adults, investigating possible confounders as well as interaction effects.</div></div><div><h3>Methods</h3><div>The overall sample included 6200 participants aged 40 to 80 years from the LIFE-Adult-Study. Body Mass Index (BMI), symptoms of depression, somatic complaints, as well as health-related factors were surveyed using validated instruments.</div></div><div><h3>Results</h3><div>Overall, 5.5 % of individuals with overweight and 7.3 % of individuals with obesity reported depressive symptoms in the past 7 days, compared to 5.8 % of individuals without obesity/overweight. At total, the prevalence of depressive symptoms was 2.2 % among individuals with overweight and 1.7 % among individuals with obesity. Multivariate regression models revealed an overall positive association between BMI and depressive symptoms (β = 0.031, <em>p</em> = 0.001), adjusting for covariates. Moreover, being unmarried, higher age, low or medium SES, more somatization and medium physical activity was significantly linked to severity of depressive symptoms.</div></div><div><h3>Conclusions</h3><div>The results underline the importance of addressing comorbidity in research and practice. While the overall number of people with both obesity and depressive symptoms in the population is low, individuals with obesity may be more vulnerable to experience depression than those without obesity. Comorbidity may be associated with consequences on overall health and quality of life. Further research is needed, especially longitudinal studies in order to explain the role and causality of socio-demographic or health-related factors.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119792"},"PeriodicalIF":4.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of metabolic obesity phenotypes with cognitive aging in middle-aged and elderly Chinese adults.","authors":"Yihui Li, Lei Yan, Pingting Yang, Jiangang Wang","doi":"10.1016/j.jad.2025.119789","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119789","url":null,"abstract":"<p><strong>Context: </strong>Previous research has demonstrated that metabolic abnormalities accelerate cognitive aging. Although obesity is closely linked to metabolic disorders, it exhibits considerable heterogeneity depending on an individual's metabolic status. However, the relationship between this metabolic heterogeneity in obesity and cognitive aging remains unclear.</p><p><strong>Objective: </strong>We aimed to analyze the effects of various metabolic obesity phenotypes on cognitive aging.</p><p><strong>Methods: </strong>A total of 7521 participants aged over 45 years from the China Health and Retirement Longitudinal Study (CHARLS) were included. Cognitive function was evaluated through both episodic memory and executive function. The relationship between different metabolic obesity phenotypes and cognitive aging was analyzed using linear mixed models, based on baseline metabolic obesity phenotypes: metabolically healthy normal weight (MHNW), metabolically healthy overweight/obesity (MHOO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight/obesity (MUOO).</p><p><strong>Results: </strong>Compared with MHNW, MUNW was associated with accelerated aging of global cognitive function (β = -0.007, 95 % CI: -0.013 to -0.001) and episodic memory (β = -0.008, 95 % CI: -0.016 to -0.001). In contrast, MHOO was associated with a slower decline in episodic memory (β = 0.011, 95 % CI: 0.002 to 0.020). However, none of the metabolic obesity phenotypes showed significant differences in executive function decline compared to MHNW.</p><p><strong>Conclusions: </strong>Overall, the MUNW phenotype was associated with accelerated aging of global cognitive function and episodic memory, while the MHOO phenotype was associated with a slower decline in episodic memory compared to MHNW. The MUOO group did not differ significantly from MHNW in the three dimensions of cognitive aging.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119789"},"PeriodicalIF":4.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}