Journal of affective disorders最新文献

{"title":"Corrigendum “Loneliness and social isolation, mediating lifestyle factors, and incidence of COPD: A prospective cohort study” [Journal of Affective Disorders 383 (2025) 387–393]","authors":"Zhen Liu, Minzhi Xu, Xiaoxv Yin","doi":"10.1016/j.jad.2025.119555","DOIUrl":"10.1016/j.jad.2025.119555","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119555"},"PeriodicalIF":4.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of depressive symptoms and lifestyles with cognitive function: results from two cross-sectional studies among middle-age and older Chinese populations","authors":"Shengli Chen ,&nbsp;Wencai Ke ,&nbsp;Xin Guan ,&nbsp;Shiru Hong ,&nbsp;Sheng Wu ,&nbsp;Zirong Yu ,&nbsp;Jie Lin ,&nbsp;Chenming Wang ,&nbsp;Ming Fu ,&nbsp;Yang Xiao ,&nbsp;Yuhan Zhou ,&nbsp;Chenliang Liu ,&nbsp;Guorong Zhong ,&nbsp;Yingqian You ,&nbsp;Yuxi Wang ,&nbsp;Hui Zhao ,&nbsp;Yichi Zhang ,&nbsp;Yansen Bai ,&nbsp;Zhengce Wan ,&nbsp;Yong Lin ,&nbsp;Huan Guo","doi":"10.1016/j.jad.2025.119573","DOIUrl":"10.1016/j.jad.2025.119573","url":null,"abstract":"<div><h3>Background</h3><div>Depression and cognitive decline are both major health problems worldwide. This study aims to investigate the effects of depressive symptoms and its joint function with lifestyles on cognitive function among the Chinese populations.</div></div><div><h3>Methods</h3><div>This research included two cross-sectional studies from Hubei (<em>n</em> = 7756) and Shanghai (<em>n</em> = 4751), China. The depressive symptoms were surveyed by the 15-item Geriatric Depression Scale (GDS-15), and cognitive function was assessed by the Mini-mental State Examination (MMSE).</div></div><div><h3>Results</h3><div>We observed significant association between depression and decreased MMSE score [β (95%CI) = −0.70 (−0.97, −0.42) and −3.15 (−3.59, −2.70) in Hubei and Shanghai, respectively] and elevated risk of MCI [OR (95%CI) = 1.59 (1.20, 2.08) and 2.75 (2.06, 3.66), respectively] in both populations. Additionally, individuals who reported physically active, kept an optimal sleep duration, and higher healthy lifestyle score (HLS) exhibited a better cognition in both populations. More importantly, the adverse associations between depressive symptoms and cognition were diminished among subjects adopting five types of healthy lifestyles (HLS = 5) [Hubei: β (95%CI) = −0.20 (−0.82, 0.41) and OR (95%CI) =0.82 (0.24, 2.12), <em>P-int</em> = 0.047 and 0.046; Shanghai: β (95%CI) = −0.80 (−1.70, 0.10) and OR (95%CI) =1.85 (0.53, 5.06), <em>P-int</em> &lt; 0.001 and 0.151]. Furthermore, we observed joint effects of non-depressed status with healthy lifestyles on cognition.</div></div><div><h3>Conclusion</h3><div>Depressive symptoms are associated with impaired cognitive function and this association could be attenuated by healthy lifestyles.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119573"},"PeriodicalIF":4.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Role of the insula in rTMS response for depression” [J. Affect. Disord. 370 (2025) 538–546]","authors":"Chien-Lin Wu ,&nbsp;Tsung-Hua Lu ,&nbsp;Wei Hung Chang ,&nbsp;Tzu-Yun Wang ,&nbsp;Huai-Hsuan Tseng ,&nbsp;Yen Kuang Yang ,&nbsp;Po See Chen","doi":"10.1016/j.jad.2025.119552","DOIUrl":"10.1016/j.jad.2025.119552","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119552"},"PeriodicalIF":4.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of micronutrients used to treat antenatal depression on rates of postnatal depression at six months: A secondary analysis of NUTRIMUM.","authors":"Maddison Mitchell, Hayley Bradley, Neville M Blampied, Roger T Mulder, Julia J Rucklidge","doi":"10.1016/j.jad.2025.119560","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119560","url":null,"abstract":"<p><strong>Background: </strong>Antenatal depression is a debilitating pregnancy condition and risk factor for postnatal depression, with estimates suggesting 39-92 % of women with antenatal depression will have postnatal depression.</p><p><strong>Aims: </strong>This study investigated rates of postnatal depression in women who had symptoms of antenatal depression and were treated antenatally with micronutrients (vitamins and minerals).</p><p><strong>Methods: </strong>Self-reported (Edinburgh Postnatal Depression Scale (EPDS)) and clinician-rated depression (Montgomery and Åsberg Depression Rating Scale (MADRS)) were assessed at six months postnatally in mothers who participated in the NUTRIMUM trial, a double-blind randomised placebo-controlled trial that investigated if micronutrients could treat symptoms of antenatal depression. At study entry, women were 12-24 weeks gestation, medication-free, and moderately depressed (≥ 13 EPDS). Depression scores were obtained six months post-birth from 61 (80.3 %) of eligible participants (those who took micronutrients during pregnancy) and compared to scores at study entry.</p><p><strong>Results: </strong>Mothers at six-month follow-up had significant reduction in their depression scores relative to study entry (Cohen's d > 2). Rates of depression, based on both EPDS (≥13; 14 %) and MADRS (≥20; 8 %), were substantially less than expected based on presence of antenatal depression, and on par with general population rates. Women who switched or added psychiatric medication postnatally (n = 6), had had fewer days of antenatal micronutrient exposure than those who didn't switch, and had higher 6-month depression scores. Postnatal micronutrient supplementation was not necessary to reduce postnatal depression.</p><p><strong>Conclusion: </strong>This study highlights the protective and symptom reduction potential of antenatal micronutrient supplementation to alleviate postnatal depression in mothers at higher risk.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119560"},"PeriodicalIF":4.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blunted perceived control effect on reward anticipation in trait anxiety","authors":"Yongyi Liang ,&nbsp;Peitong An ,&nbsp;Guanglong Liu ,&nbsp;Ya Zheng","doi":"10.1016/j.jad.2025.119559","DOIUrl":"10.1016/j.jad.2025.119559","url":null,"abstract":"<div><h3>Background</h3><div>A lack of perceived control contributes to the development and maintenance of anxiety. Previous studies have shown the deficiency of perceived control in buffering negative emotions in anxiety. However, it remains unclear whether the control-related impairment in anxiety also manifests in positive scenarios.</div></div><div><h3>Methods</h3><div>We addressed this issue by recording event-related potentials from low (<em>N</em> = 33) and high (<em>N</em> = 33) trait-anxiety individuals as they performed a gambling task to earn monetary rewards under high and low perceived-control conditions.</div></div><div><h3>Results</h3><div>Our results showed that anxiety was associated with a blunted neural effect of perceived control on reward anticipation as indexed by the cue-P3 and stimulus-preceding negativity. This diminished control effect was not affected by depressive symptoms and was not observed during reward consummatory phase as indexed by the reward positivity and feedback P3.</div></div><div><h3>Limitations</h3><div>Our findings should be extended to include negative scenarios and other forms of perceived control.</div></div><div><h3>Conclusions</h3><div>Our findings elucidate that anxiety is associated with a deficiency in boosting reward anticipation through perceived control exercised by choice and thus extend the dysfunctional perceived control from the negative to the positive domain, highlighting its valence-independent nature in trait anxiety.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119559"},"PeriodicalIF":4.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of reward behavior in patients with MDD and partial response to SSRI therapy treated with vortioxetine versus desvenlafaxine: Experience with the effort expenditure for rewards task (EEfRT) in the VIVRE study","authors":"Hartej Gill ,&nbsp;Roger S. McIntyre ,&nbsp;Michael Cronquist Christensen","doi":"10.1016/j.jad.2025.119563","DOIUrl":"10.1016/j.jad.2025.119563","url":null,"abstract":"<div><h3>Background</h3><div>Anhedonia is a hallmark symptom of major depressive disorder (MDD), associated with impairments in various aspects of reward. VIVRE is the first study in patients with MDD receiving antidepressant therapy to include longitudinal assessment of reward behavior using the Effort-Expenditure for Rewards Task (EEfRT), a validated behavioral paradigm for the objective assessment of reward and effort-based decision-making in patients with MDD.</div></div><div><h3>Methods</h3><div>Randomized, double-blind study of vortioxetine (10 or 20 mg/day) versus desvenlafaxine (50 mg/day) in adults with MDD and partial response to selective serotonin reuptake inhibitor monotherapy. Motivation for reward based on the proportion of hard trial choices was assessed at baseline and after 8 weeks of treatment.</div></div><div><h3>Results</h3><div>There was no difference in the proportion of hard trial choices between the vortioxetine (<em>n</em> = 288) and desvenlafaxine (<em>n</em> = 300) treatment groups at baseline. Minimal change in parameters of reward motivation was seen over the 8-week treatment period in either group. The between-group difference in the proportion of hard trial choices at week 8 was not statistically significant (odds ratio: 0.97 [95 % CI: 0.82, 1.14]; <em>P</em> = 0.72). Similar results were obtained when controlling for reward probability, reward magnitude, trial number, and sex, or when limiting to the first 50 trials (excluding computer-selected trials).</div></div><div><h3>Limitations</h3><div>Exploratory analyses evaluating the utility of the EEfRT in clinical populations.</div></div><div><h3>Conclusions</h3><div>Experience from the VIVRE study suggests that further research is required to fully determine the clinical utility of the EEfRT for assessment of antidepressant treatment effects in patients with MDD.</div></div><div><h3>Trial registration</h3><div>NCT04448431.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119563"},"PeriodicalIF":4.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of non-invasive brain stimulation in reducing anhedonia and apathy in major depressive disorder and schizophrenia: A meta-analysis","authors":"Xian Li ,&nbsp;Idy S.C. Man ,&nbsp;Robin Shao ,&nbsp;Xuanhao Zhao ,&nbsp;Shiyun Wu ,&nbsp;Zhongwan Liu ,&nbsp;Kangguang Lin","doi":"10.1016/j.jad.2025.119561","DOIUrl":"10.1016/j.jad.2025.119561","url":null,"abstract":"<div><h3>Background</h3><div>Anhedonia and apathy are core symptoms of Major Depressive Disorder (MDD) and schizophrenia, and respectively refer to deficit in reward processing and motivation. Emerging evidence indicates noninvasive brain stimulation (NIBS) such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) may be effective in treating anhedonia and apathy.</div></div><div><h3>Objective</h3><div>To quantitatively synthesize existing literature on the efficacy of TMS and tDCS in alleviating anhedonia and apathy among individuals with MDD and schizophrenia.</div></div><div><h3>Methods</h3><div>This meta-analysis synthesized findings from 22 previous studies including adults with MDD and schizophrenia (total <em>N</em> = 1258, female% = 43.73 %, age = 37.33 ± 8.35 years, PROSPERO registration no. CRD42023426223). A multilevel random-effect model was adopted to compute pooled effect size and heterogeneity across studies.</div></div><div><h3>Results</h3><div>NIBS shows an overall significant effect in reducing anhedonia and apathy among individuals with MDD and schizophrenia, which is more robust for unilateral excitatory stimulation over the left DLPFC and for RCT studies. While TMS shows no specific effect in reducing anhedonia, it shows a significant effect in decreasing apathy, with both effects dependent on the outcome measurement method. Limited evidence shows significant overall effect of tDCS in reducing anhedonia and apathy, but its specific effect on apathy is inconclusive.</div></div><div><h3>Conclusions</h3><div>NIBS methods show overall modest effects in reducing anhedonia and apathy in MDD and schizophrenia, but the heterogeneity is high that may result from limited study number and methodological variations such as stimulation location. More studies need to be conducted particularly for tDCS intervention, and using task and specific measures of anhedonia and apathy.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119561"},"PeriodicalIF":4.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety moderates the effect of sleep on selective forgetting","authors":"Risto Halonen ,&nbsp;Tommi Makkonen ,&nbsp;Liisa Kuula ,&nbsp;Anu-Katriina Pesonen","doi":"10.1016/j.jad.2025.119562","DOIUrl":"10.1016/j.jad.2025.119562","url":null,"abstract":"<div><div>While anxiety predisposes to distressing memories, the role of sleep in maintaining or attenuating unwanted memories has been understudied. This study aims to fill this knowledge gap by examining sleep-driven selective memory consolidation using a directed forgetting (DF) paradigm. DF refers to the intentional suppression of certain memories during encoding, and it is usually observed in both anxious and non-anxious individuals during wakefulness. While sleep potentially enhances DF, it is unclear how anxiety interacts with sleep.</div><div>The sample (<em>N</em> = 58) was divided into low- and high-anxiety subgroups based on self-reported symptoms (GAD-7). The participants encoded to memory 120 face images (neutral/fearful). According to item-method DF, each image was instantly followed by Remember (R) or Forget (F) cue. Memory retrievals took place immediately, after a daytime nap in the sleep laboratory, and after two days. DF effect denoted the difference between R-cued and F-cued image recognition success.</div><div>Overall, relative to F-cued, R-cued images were better recognized. This DF effect was moderated by anxiety and sleep: in low-anxiety individuals only, the magnitude of the DF effect increased significantly over the nap. This increase was associated with sleep spindle density. Event-related potential amplitudes at encoding associated with the DF effect at the immediate retrieval, but not at the later assessments.</div><div>Sleep-related memory processing may be altered in individuals with elevated anxiety, making it harder to differentiate important from irrelevant information. This mechanism may contribute to the persistence of unwanted memories in anxiety. Understanding how sleep interacts with anxiety can open novel intervention possibilities.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119562"},"PeriodicalIF":4.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Mendelian randomization of the human plasma proteome to identify therapeutic targets linking aging and frailty to perioperative delirium","authors":"Jian Tang ,&nbsp;Zhengyu Qian ,&nbsp;Zhengyin Zhu ,&nbsp;Hongjin Qin ,&nbsp;Guangyu Cai ,&nbsp;Yaqi Wang ,&nbsp;Zhu Wei ,&nbsp;Xue Rao ,&nbsp;Yang Liu ,&nbsp;Xiaohua Zou ,&nbsp;Yimin Ren","doi":"10.1016/j.jad.2025.119471","DOIUrl":"10.1016/j.jad.2025.119471","url":null,"abstract":"<div><h3>Background</h3><div>Perioperative delirium is a growing concern in the aging population, posing significant risks to frail elderly patients. While frailty is associated with delirium, the underlying mechanisms remain unclear.</div></div><div><h3>Methods</h3><div>We conducted an analysis of data derived from 3788 plasma proteins in a protein quantitative trait locus (pQTL) study encompassing 4709 participants. Utilizing Mendelian randomization (MR) in conjunction with genome-wide association study (GWAS) data, we identified proteins that exhibit significant associations with delirium. Additionally, we investigated the bidirectional relationship between delirium and aging-related indicators, such as the frailty index (FI), Intrinsic Epigenetic Age Acceleration (IEAA), PhenoAge, and life expectancy. This was achieved through mediation analysis and Bayesian colocalization to assess the intermediary effects of these indicators. Finally, we assessed the therapeutic potential of the identified proteins via molecular docking studies.</div></div><div><h3>Results</h3><div>MR analysis revealed causal relationships between delirium and several aging-related indicators, including FI, IEAA, PhenoAge, and life expectancy. Eleven proteins were causally associated with delirium. Mediation analysis showed that the effects of HIBCH and IMPAD1 on delirium were mediated by PhenoAge, while IEAA mediated the effect of MICB. MST1's effect on delirium was mediated by FI and life expectancy. Bayesian colocalization confirmed strong associations between HIBCH, MST1, and delirium. Molecular docking studies indicated that MST1 and HIBCH exhibited low binding energies with midazolam and dexmedetomidine, suggesting their potential as therapeutic targets.</div></div><div><h3>Conclusion</h3><div>HIBCH and MST1 are key players in delirium pathophysiology and represent promising therapeutic candidates. Their involvement in delirium warrants further investigation in clinical research.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119471"},"PeriodicalIF":4.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of postpartum depression on infant development in the first year of life","authors":"Samira Alfayumi-Zeadna ,&nbsp;Sabaa Masarwe ,&nbsp;Yifat Findling ,&nbsp;Anat Ereli ,&nbsp;Norm O'Rourke","doi":"10.1016/j.jad.2025.119558","DOIUrl":"10.1016/j.jad.2025.119558","url":null,"abstract":"<div><h3>Introduction</h3><div>Postpartum depression (PPD) is a common disorder affecting approximately 1 in 7 women within the first year after childbirth. PPD can affect mother-infant interactions as well as the child's cognitive, social–emotional, and physical development. This study aims to examine the impact of PPD symptoms (PPDs) on infant development in the first year across various developmental domains.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted with 683 mothers, 1–12 months postpartum, recruited through social media. Data were collected using self-report questionnaires, including Edinburgh Postnatal Depression Scale (EPDS). Infant development was assessed using the Israeli Ministry of Health's Developmental Milestone Guidelines Scale, covering social, language, fine motor, and gross motor domains. Multivariable logistic regression was used to identify predictors of developmental delays.</div></div><div><h3>Results</h3><div>The study found that 31.8 % of mothers reported elevated PPDs (EPDS≥10). Infants of mothers with elevated PPDs were significantly more likely to exhibit developmental delays (23.0 %) compared to mothers with lower PPDs (12.2 %) (OR = 1.77, 95%CI = 1.1, 2.8). Elevated PPDs were significantly associated with delays in social, language, and fine motor development. Additionally, infants aged 1–3 months had higher risk of developmental delays compared to those aged 10–12 months (OR = 2.18, 95%CI = 1.2, 3.9). Parental concerns about infant development also predicted of delays (OR = 2.08, 95%CI = 1.2, 3.4).</div></div><div><h3>Conclusion</h3><div>PPD increases the risk of developmental delays in infants, particularly in socio-emotional, language, and fine motor domains. These results highlight the importance of early screening and intervention for at-risk mothers are critical to reduce these effects on infant development. Further research is needed to examine cultural differences in PPD's effects on infant development.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119558"},"PeriodicalIF":4.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}