Journal of affective disorders最新文献

{"title":"E-health intervention for co-occurring at-risk alcohol use and depressive symptoms: Reach, adherence, and two-year effects of a randomized controlled trial","authors":"D. Guertler ,&nbsp;S. Baumann ,&nbsp;A. Moehring ,&nbsp;K. Krause ,&nbsp;J. Freyer-Adam ,&nbsp;S. Ulbricht ,&nbsp;G. Bischof ,&nbsp;A. Batra ,&nbsp;H.J. Rumpf ,&nbsp;S. Wurm ,&nbsp;M. Lucht ,&nbsp;U. John ,&nbsp;C. Meyer","doi":"10.1016/j.jad.2025.04.095","DOIUrl":"10.1016/j.jad.2025.04.095","url":null,"abstract":"<div><h3>Background</h3><div>This randomized controlled trial explored reach, adherence, and two-year effects of a proactive e-health intervention for co-occurring at-risk alcohol use and depressive symptoms (ITE).</div></div><div><h3>Methods</h3><div>German medical care patients were screened for at-risk alcohol use and subthreshold depression. Over 6 months, ITE participants received 6 individualized feedback letters and weekly text messages. Primary outcome was change in a composite measure including problematic alcohol use (Alcohol Use Disorders Identification Test consumption questions) and depressive symptoms (two subscales of the Patient-Health-Questionnaire-8) from baseline to 6, 12, and 24 months. Analyses were adjusted for education, setting, major depression, and baseline differences.</div></div><div><h3>Results</h3><div>Among eligible patients invited, 51 % agreed to participate; 40 % completed the baseline interview and were randomized to ITE (<em>n</em> = 64) or assessment only (<em>n</em> = 68). Within ITE participants, 73 % received all intervention components. A latent change model revealed a small, insignificant impact of study group on the composite measure at 6 (d = −0.49, β = −0.41, <em>p</em> = 0.06) and 12 months (d = −0.26, β = −0.22, <em>p</em> = 0.35), diminishing at 24 months (d = −0.06, β = −0.04, <em>p</em> = 0.88). Secondary analyses showed a non-significant trend at 6 months, suggesting possible effect modification by baseline major depression (β = 0.80, <em>p</em> = 0.098), with larger effects in those without major depression.</div></div><div><h3>Limitations</h3><div>Self-reported outcomes; psychotherapy status unknown.</div></div><div><h3>Discussion</h3><div>ITE showed high adherence and overall small, although non-significant, intervention effects up to month 12. The potential effect moderation warrants further investigation in larger samples.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 355-365"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-related differences in the associations between wishing to die, grip strength, and physical activity: An analysis in European middle-aged and older adults","authors":"Marcelo de Maio Nascimento ,&nbsp;Andreas Ihle ,&nbsp;Gerson Ferrari ,&nbsp;Élvio R. Gouveia ,&nbsp;Adilson Marques","doi":"10.1016/j.jad.2025.04.098","DOIUrl":"10.1016/j.jad.2025.04.098","url":null,"abstract":"<div><h3>Background</h3><div>The desire to die among older adults has been reported in several European countries. This study aimed to investigate the associations between grip strength (GS) and the frequency of weekly moderate physical activity (MPA) with wish to die (WTD) in European middle-aged and older adults.</div></div><div><h3>Methods</h3><div>A cross-sectional analysis was conducted with 39,377 participants (22,313 women) from 27 European countries, aged ≥50 years, responding to wave 8 of the SHARE project. GS was assessed for both hands by a dynamometer, WTD was obtained by asking: ‘In the last month, have you felt that you would rather be dead?’ from the 12-item EURO-D scale, and the weekly frequency of moderate physical activity (MPA) was self-reported.</div></div><div><h3>Results</h3><div>Greater GS (per 1 unit) was associated with a 26 % to 55 % lower chances of WTD among men. Among women, a 1 kg increase in GS was associated with a 40 % to 70 % lower chance of WTD. MPA once a week or more than once a week (compared to MPA less than once a week) was associated with a 57 % and 58 % lower chance of WTD among men. Among women, MPA once a week or more than once a week (compared to MPA less than once a week) was associated with 44 % and 48 % lower odds of WTD.</div></div><div><h3>Conclusion</h3><div>GS was inversely associated with WTD, particularly in women. Engaging in MPA once a week showed a greater association with less WTD for both sexes than MPA more than once a week, particularly in men.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 256-263"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifetime history of depression and eating behaviours: a co-twin control study of the TwinsUK registry","authors":"Hiba Mutwalli ,&nbsp;Moritz Herle ,&nbsp;Carol Kan ,&nbsp;Johanna L. Keeler ,&nbsp;Claire Steves ,&nbsp;Janet Treasure ,&nbsp;Hubertus Himmerich ,&nbsp;Ellen J. Thompson","doi":"10.1016/j.jad.2025.04.111","DOIUrl":"10.1016/j.jad.2025.04.111","url":null,"abstract":"<div><h3>Background</h3><div>The extent to which depression impacts eating behaviours, and the mechanisms underpinning their relationship are unclear. We aim to investigate the relationship between depression diagnosis and eating behaviours.</div></div><div><h3>Methods</h3><div>We analysed data from 1426 participants of the twins UK registry, which includes 722 monozygotic (MZ) and 702 dizygotic (DZ) twins. Eating behaviours were measured using the three-factor eating questionnaire while depression and antidepressant usage were self-reported. Co-twin control design was used to model the association between depression and eating. Sensitivity tests were implemented to exclude those using antidepressants.</div></div><div><h3>Results</h3><div>The heritability estimates for eating behaviours were between 35 and 41 %. Twins with a history of depression had higher scores on the emotional (<em>d</em> = -0.31) and constrained eating (<em>d</em> = -0.18). The intraclass correlations revealed a higher covariation in MZ compared to DZ twins. A moderate relationship was observed between lifetime depression and uncontrolled (<em>β</em> = 0.61, 95 % CI [0.17; 1.06]), emotional (<em>β</em> = 0.38, 95 % CI [0.22; 0.55]) and restrained eating (<em>β</em> = 0.43, 95 % CI [0.10; 0.77]). After removing those on antidepressants (<em>n</em> = 195), the relationship between eating and depression attenuated, indicating a potential influence of antidepressants in this association.</div></div><div><h3>Conclusion</h3><div>Our findings suggest the association between depression and eating can be partly explained by pre-existing genetic and environmental vulnerabilities. Understanding the mechanisms underlying this relationship could guide the development of effective management strategies, including personalized nutrition plans, integrated mental and dietary care, and regular monitoring to mitigate the risk of maladaptive eating behaviours and eating disorders.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 264-273"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of lifestyle and family environment factors on mental health problems in Hong Kong preschoolers","authors":"Keith T.S. Tung ,&nbsp;Xiaoqing Zhang ,&nbsp;Rosa S. Wong ,&nbsp;Hung-Kwan So ,&nbsp;Ka-Man Yip ,&nbsp;Jason C.S. Yam ,&nbsp;Sherry K.W. Chan ,&nbsp;Winnie W.Y. Tso ,&nbsp;Patrick Ip","doi":"10.1016/j.jad.2025.04.114","DOIUrl":"10.1016/j.jad.2025.04.114","url":null,"abstract":"<div><h3>Background and aims</h3><div>Existing studies that simultaneously consider the effects of lifestyle and family environment factors on mental health problems (MHPs), particularly in preschoolers, are limited. This study aims to explore lifestyle and family environment factors associated with MHPs, externalising problems (EPs) and internalising problems (IPs) in preschoolers.</div></div><div><h3>Methods</h3><div>This territory-wide, school-based study conducted from 2020 to 2022 involved 1926 preschoolers. MHPs, EPs, and IPs and factors such as sleep duration, sleep latency, entertainment screen time, educational screen time, parent-child recreation and learning activities were assessed. Linear and logistic regression analyses were used to explore the relationships between these factors and MHPs, EPs, and IPs.</div></div><div><h3>Results</h3><div>The average sleep duration was 9.94 h per day, average screen time of 2.53 h per day, and 42.6 % experienced sleep latency exceeding 20 min per day among preschoolers (mean age: 4.39 years, 49.1 % female). Adjusted analyses showed that decreased parent-child recreation activities, prolonged sleep latency and excessive entertainment screen time were associated with increased MHPs, EPs, and IPs (β: 0.05 to 0.20, all <em>p</em> &lt; 0.05). Weekend sleep duration of &lt;10 h per day, sleep latency of &gt;20 min per day, and educational screen time of &gt;30 min per day were identified as risk factors for MHPs, EPs, and IPs, with an adjusted odds ratio ranging from 1.32 to 2.32 (all <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Preschoolers' lifestyle and family environment factors are associated with MHPs, EPs, and IPs respectively. Ensuring adequate sleep duration, avoiding sleep latency exceeding 20 min per day, reducing entertainment screen time, limiting educational screen time to 30 min per day, and increasing parent-child interactions may help to minimise mental health problems.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 498-506"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eating disorders, psychiatric comorbidities, and suicide","authors":"Li-Chi Chen ,&nbsp;Ya-Mei Bai ,&nbsp;Shih-Jen Tsai ,&nbsp;Chih-Ming Cheng ,&nbsp;Mu-Hong Chen","doi":"10.1016/j.jad.2025.04.090","DOIUrl":"10.1016/j.jad.2025.04.090","url":null,"abstract":"<div><h3>Background</h3><div>Evidence suggests a strong association between eating disorders and suicidality, including suicidal ideation and suicide attempts. However, whether eating disorders independently increase the risk of suicide remains unclear.</div></div><div><h3>Methods</h3><div>From Taiwan's National Health Insurance Research Database, we collected the data (2003–2017) of 18,284 patients with eating disorders (case group). Among these patients, 2035 (11.13 %) had anorexia nervosa, 10,658 (58.29 %) had bulimia nervosa, and 5591 (30.58 %) had other eating disorders. These patients were matched (1:4; by age [birth year] and sex) with 73,136 individuals without eating disorders (control group). For both groups, the rates of suicide over the same period were estimated using data from the Database of All-Cause Mortality.</div></div><div><h3>Results</h3><div>A time-dependent Cox regression model, which was adjusted for demographic characteristics, psychiatric comorbidities, and Charlson Comorbidity Index scores, indicated that the risk of suicide was higher in the case group (hazard ratio [HR]: 2.51), particularly among patients with bulimia nervosa (HR: 2.59) or other eating disorders (HR: 2.31), than in the control group. After adjustments for psychiatric comorbidities, the association between anorexia nervosa and suicide became nonsignificant. Eating disorder-related psychiatric comorbidities, particularly depressive disorder (HR: 15.89), further increased the risk of suicide in the case group.</div></div><div><h3>Conclusion</h3><div>Eating disorders, particularly bulimia nervosa and other eating disorders, serve as independent risk factors for suicide, regardless of psychiatric comorbidities. Thus, clinicians and mental health providers should develop suicide prevention strategies targeting eating disorders.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 290-295"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress sensitization to psychological adjustment following childhood adversity: Moderation by serotonergic multilocus genetic variation","authors":"Zihao Zeng ,&nbsp;Shuangjin Liu ,&nbsp;Qin Yang ,&nbsp;Hongcai Wang ,&nbsp;Zhen He ,&nbsp;Yiqiu Hu","doi":"10.1016/j.jad.2025.04.068","DOIUrl":"10.1016/j.jad.2025.04.068","url":null,"abstract":"<div><h3>Background</h3><div>Exposure to adverse childhood experiences may heighten adolescents' sensitivity to stress, which influences their psychological adjustment over their lifetimes. Some research indicates that serotonergic genetic variation moderates how environmental stressors impact psychological adjustment. However, there are recognized limitations in examining gene-environment interactions using only single polymorphisms.</div></div><div><h3>Methods</h3><div>The present study employed a multilocus genetic profile score (MGPS) approach to measure serotonergic genetic variations and examines their interaction with childhood abuse and friendship quality as predictors of the outcomes of psychological adjustment (depressive symptoms and sleep problems) in an adolescent sample (14.15 ± 0.63 years; <em>N</em> = 525).</div></div><div><h3>Results</h3><div>Serotonergic genetic factors moderated stress sensitivity induced by adverse childhood experiences. Adolescent psychological adjustment appeared to result from interactions between genetics and the environments. These findings were further supported by rigorous significance testing and sensitivity analyses.</div></div><div><h3>Conclusion</h3><div>The results highlight the strong utility of using MGPS to investigate gene-environment-environment interactions related to adolescent psychological adjustment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 316-324"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mobile app-based intervention for paternal perinatal depression, anxiety, and stress: A randomised controlled trial","authors":"Samantha J. Teague ,&nbsp;Adrian B.R. Shatte ,&nbsp;Matthew Fuller-Tyszkiewicz ,&nbsp;Delyse M. Hutchinson","doi":"10.1016/j.jad.2025.04.075","DOIUrl":"10.1016/j.jad.2025.04.075","url":null,"abstract":"<div><h3>Background</h3><div>Paternal perinatal mental health significantly impacts family outcomes, yet fathers are often overlooked and underserved in mental health services. This study evaluates the efficacy of a mindfulness-based cognitive behaviour therapy intervention delivered via mobile app to address paternal perinatal depression, anxiety, and stress symptoms.</div></div><div><h3>Method</h3><div>A randomised controlled trial was conducted with perinatal fathers experiencing moderate depression, anxiety, or stress symptoms. Participants were assigned to either the Rover app mindfulness-based CBT intervention (<em>n</em> = 81) or an active control app, moodmonitor (<em>n</em> = 75). Primary outcomes were depression (EPDS), anxiety, and stress (DASS21); secondary outcomes included social support, parenting self-efficacy, and couple relationship quality. Post-test analysis occurred at four weeks, with an additional eight-week follow-up for the intervention group.</div></div><div><h3>Results</h3><div>Contrary to hypotheses, no differences were found between groups for depression, anxiety, and stress symptoms. Both groups showed significant reductions in anxiety (intervention d = −1.7, control d = −1.94) and stress (intervention <em>d</em> = −2.9, control <em>d</em> = −2.8) and improved couple relationship quality. Rover users maintained improvements at 8-week follow-up. Fathers with severe baseline depression experienced greater reductions in depression using the Rover app (<em>b</em> = 5.36, <em>p</em> &lt; 0.01).</div></div><div><h3>Limitations</h3><div>Low adherence to the intervention and moderate attrition over the study duration.</div></div><div><h3>Conclusions</h3><div>Although the intervention was acceptable to fathers, treatment adherence was low, highlighting the need for more engaging content. App-based interventions show potential benefits for paternal mental health, but user engagement must be improved. This study contributes to the growing literature on digital interventions for fathers' mental health and emphasizes the importance of including fathers in perinatal mental health research.</div></div><div><h3>Trial registration</h3><div>Australian and New Zealand Clinical Trials Registry: ACTRN12621000275864.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 325-335"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A culturally sensitive act-belong-commit-based school intervention reduces the burden of anxiety and depression in adolescents: A pilot cluster-randomized trial from Uganda","authors":"Davy Vancampfort ,&nbsp;Philip B. Ward ,&nbsp;Japheth Nkiriyehe Kwiringira ,&nbsp;Tine Van Damme ,&nbsp;Simon Rosenbaum ,&nbsp;James Mugisha","doi":"10.1016/j.jad.2025.04.128","DOIUrl":"10.1016/j.jad.2025.04.128","url":null,"abstract":"<div><h3>Introduction</h3><div>Schools can be pivotal in addressing mental health challenges, especially in low-income settings like Uganda. However, randomized controlled trials tailored to cultural and contextual factors are scarce. This pilot cluster-randomized trial examines the impact of a culturally sensitive Act-Belong-Commit (ACT) intervention, combined with physical activity, sleep hygiene and stress management measures on anxiety and depression among Ugandan adolescents attending secondary school.</div></div><div><h3>Methods</h3><div>A total of 2598 adolescents (1295 intervention; 1303 control; 1199 boys [46.1 %]; mean age 16.3 ± 1.0 years) from four secondary schools were randomized by school to either a 12-week, weekly two-hour teacher- and peer-led ACT intervention or a care-as-usual control. Anxiety (GAD-7) and depression (PHQ-9-A) were measured at baseline and immediately post-intervention. Childhood trauma (CTQ-SF), self-reported health, wealth, and food security were assessed at baseline. Linear mixed modeling was used to evaluate intervention effects.</div></div><div><h3>Results</h3><div>At baseline, the mean GAD-7 score was 6.4 ± 4.4 and PHQ-9-A was 7.4 ± 5.1. The intervention group showed greater improvements in mental health, with moderate effects on anxiety (Cohen's d = 0.50, 95 % CI = 0.42–0.57) and small effects on depression (Cohen's d = 0.44, 95 % CI = 0.36–0.52). Moderation analyses were based on pre-specified baseline variables.</div></div><div><h3>Conclusion</h3><div>This pilot trial provides preliminary evidence that a culturally adapted ACT intervention combined physical activity, sleep hygiene and stress management measures may be a promising whole-school approach to reduce anxiety and depression in adolescents. Further trials with more clusters are needed.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 399-406"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of social robot interventions on anxiety in children in clinical settings: a systematic review and meta-analysis","authors":"Ruo-Yan Wu ,&nbsp;Xin-Heng Li ,&nbsp;Yi-Chen Li ,&nbsp;Zhi-Hong Ren ,&nbsp;Bing-Xiang Yang ,&nbsp;Zhen-Tao Liu ,&nbsp;Bao-Liang Zhong ,&nbsp;Chen-Ling Liu","doi":"10.1016/j.jad.2025.04.102","DOIUrl":"10.1016/j.jad.2025.04.102","url":null,"abstract":"<div><h3>Aims</h3><div>Children in clinical settings are prone to anxiety due to developmental limitations, which hinders treatment progress. This systematic review and meta-analysis aimed to evaluate the efficacy of social robot interventions compared to routine care or alternative non-pharmacological strategies in reducing anxiety among children aged 4–12 years undergoing medical procedures in clinical settings, based on evidence from randomized controlled trials.</div></div><div><h3>Methods</h3><div>The review protocol was prospectively registered in PROSPERO. Five electronic databases PubMed, Web of Science, Embase, Cochrane Library and PsycINFO were searched for randomized controlled trials (RCTs) examining the effects of SRs on children's anxiety. The search ends on 1 December 2024. A total of 10 RCTs meeting the inclusion criteria were identified, involving 877 children aged 4–12 years.</div></div><div><h3>Results</h3><div>The meta-analysis reveals a significant reduction in anxiety levels among children who interacted with social robots in clinical settings. Subgroup analyses showed that 1) Both inpatient and outpatient children exhibited reduced anxiety levels. 2) School-age children experienced a decrease in anxiety following interventions with social robots. 3) The social robots were effective in alleviating children's anxiety using distraction techniques and psycho-educational interventions.</div></div><div><h3>Conclusions</h3><div>This meta-analysis is the first to summarize the effects of social robots on anxiety in children and finds an overall positive trend. It's more effective than traditional psychotherapy and has no adverse effects due to drug use. In the context of care shortages, social robots represent a significant tool for reducing anxiety among children in clinical settings and demonstrate promising potential.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 304-315"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Ketamine and Esketamine on Measures of Quality of Life in Major Depressive Disorder and Treatment-Resistant Depression: A Systematic Review","authors":"Morgan C.H. Cheng ,&nbsp;Christine E. Dri ,&nbsp;Hana Ballum ,&nbsp;Kyle Valentino ,&nbsp;William Cheung ,&nbsp;Kayla M. Teopiz ,&nbsp;Sabrina Wong ,&nbsp;Roger S. McIntyre","doi":"10.1016/j.jad.2025.04.119","DOIUrl":"10.1016/j.jad.2025.04.119","url":null,"abstract":"<div><h3>Introduction</h3><div>The rapid and clinically meaningful antidepressant effects of ketamine and esketamine are well-established in major depressive disorder (MDD) and treatment-resistant depression (TRD) as evidenced by improvement in clinician- and patient-reported depression measures. However, there remains a need to determine how these agents affect patient-reported quality of life (QoL). Herein, we aimed to systematically review extant studies evaluating the effect of ketamine and esketamine on QoL measures.</div></div><div><h3>Methods</h3><div>A literature search was conducted on online databases (PubMed, Scopus, Web of Science, Medline, and clinicaltrials.gov) for articles from inception to September 30th, 2024, reporting on the association between ketamine/esketamine and measures of QoL in persons diagnosed with MDD or TRD. A risk of bias assessment was conducted using the ROBINS-1 tool and the Newcastle-Ottawa Scale.</div></div><div><h3>Results</h3><div>Five studies were identified that investigated the association between ketamine/esketamine and measures of QoL in persons with MDD or TRD. Scales used to measure QoL included the WHOQOL-BREF scale, Assessment of Quality of Life 8D test, and the EuroQol-5 Dimension-5 Layers. Statistically significant findings (<em>p</em> &lt; 0.001) suggest that ketamine and esketamine improve measures of QoL in persons with MDD or TRD. However, an overall moderate risk of bias was observed in the papers included in this analysis.</div></div><div><h3>Discussion</h3><div>Extant studies suggest that ketamine and esketamine treatment are associated with improvement in QoL measures in adults with MDD or TRD. Limitations of this study include hetergeneity in the types of QoL scales as well as study study duration among the studies included. Near-term research priorities should endeavour to investigate the effect of ketamine and esketamine on specific domains of QoL, respectively.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 438-442"},"PeriodicalIF":4.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}