Journal of affective disorders最新文献

{"title":"Attention and emotion in adolescents with ADHD; A time-varying functional connectivity study.","authors":"Halima Rafi, Jessica Lee Samson, Juan Barrios Rudloff, Elena Poznyak, Melissa Gauthey, Nader Perroud, Martin Debbané","doi":"10.1016/j.jad.2024.11.036","DOIUrl":"https://doi.org/10.1016/j.jad.2024.11.036","url":null,"abstract":"<p><strong>Background: </strong>This study assessed adolescent brain-behavior relationships between large-scale dynamic functional network connectivity (FNC) and an integrated attention-deficit/hyperactivity disorder (ADHD) phenotype, including measures of inattention, impulsivity/hyperactivity and emotional dysregulation. Despite emotion dysregulation being a core clinical feature of ADHD, studies rarely assess its impact on large-scale FNC.</p><p><strong>Methods: </strong>We conducted resting-state functional magnetic resonance imaging in 78 adolescents (34 with ADHD) and obtained experimental and self-reported measures of inattention, impulsivity/hyperactivity, and emotional reactivity. We used multivariate analyses to evaluate group differences in dynamic FNC between the default mode, salience and central executive networks, meta-state functional connectivity and ADHD symptomology.</p><p><strong>Results: </strong>We present two significant group*behavior effects. Compared to controls, adolescents with ADHD had 1) diminished salience network-centered dynamic FNC that was driven by an integrated ADHD phenotype (p < .004, r = 0.57) and 2) more variable patterns of global connectivity, as measured through meta-state analysis, which were driven by heightened emotional reactivity (p < .002, r = 0.63).</p><p><strong>Conclusions: </strong>Atypical patterns of dynamic FNC in adolescents with ADHD are associated with the affective and cognitive components of ADHD symptomology. Limitations include sample size and self-reported measures of emotional reactivity.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous ketamine versus electroconvulsive therapy for major depressive disorder or bipolar depression: A meta-analysis of randomized controlled trials.","authors":"Zhan-Ming Shi, Xian-Jun Lan, Qing Chen, Jun-Jun Chen, Zhi-Ang Su, Xing-Bing Huang, Yu-Ping Ning, Xin-Hu Yang, Xin Wei, Wei Zheng","doi":"10.1016/j.jad.2024.11.034","DOIUrl":"https://doi.org/10.1016/j.jad.2024.11.034","url":null,"abstract":"<p><strong>Background: </strong>Intravenous (IV) ketamine has been evaluated alongside electroconvulsive therapy (ECT) in addressing major depressive disorder (MDD) or bipolar depression (BD), though the comparative outcomes remain inconclusive. This meta-analysis aimed to provide a systematic assessment of the efficacy, safety, and tolerability of IV ketamine relative to ECT for treating MDD or BD.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) comparing IV ketamine and ECT in terms of efficacy, safety, and tolerability for MDD or BD were identified and reviewed. Three independent investigators extracted relevant data, which was synthesized using RevMan 5.3 software under a random effects model.</p><p><strong>Results: </strong>Five RCTs encompassing 664 patients diagnosed with MDD or BD were analyzed. At 24 h post-initial treatment, IV ketamine demonstrated a statistically greater reduction in depressive symptoms compared to ECT (standardized mean difference (SMD) = -0.53; 95 % CI = -1.03 to -0.04; P = 0.04; I² = 80 %). However, no significant differences were observed between groups in terms of the study-defined response (risk ratio (RR) = 1.49; 95 % CI = 0.08 to 28.42; P = 0.79; I² = 0 %) at 24 h. Similarly, no notable differences were found for depressive symptom improvement (SMD = -0.48; 95 % CI = -2.41 to 1.45; P = 0.63; I² = 99 %), the study-defined response (RR: 0.96, 95 % CI: 0.70 to 1.31; P = 0.79; I² = 75 %) or remission (RR: 0.91, 95 % CI: 0.45 to 1.82; P = 0.78; I² = 90 %) at the end-of-treatment visit. Among the three RCTs (60 %) comparing the neurocognitive outcomes of IV ketamine and ECT through varying test batteries, results were inconsistent. IV ketamine was associated with marked increases in dissociation, blurred vision, dizziness, and diplopia, while ECT led to a significant rise in muscle pain (all Ps < 0.05). Discontinuation rates due to any cause were comparable between both groups (P > 0.05).</p><p><strong>Conclusion: </strong>IV ketamine demonstrates a faster onset of antidepressant effects compared to ECT, despite both treatments yielding comparable outcomes at the end-of-treatment visit for patients with MDD or BD. However, large-scale RCTs are required to thoroughly evaluate the long-term efficacy and safety of IV ketamine relative to ECT in these populations.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and psychometric properties of the bipolar prodrome symptom interview and scale-full prospective Chinese version to assess individuals at risk for bipolar disorder","authors":"Jingwen Sun ,&nbsp;Zhikang Mao ,&nbsp;Shengmin Zhang ,&nbsp;Shuzhe Zhou ,&nbsp;Tianhang Zhou ,&nbsp;Chenmei Xie ,&nbsp;Yilin Yuan ,&nbsp;Xinrui Zhao ,&nbsp;Chaoyue Wang ,&nbsp;Yantao Ma ,&nbsp;Hong Ma ,&nbsp;Lili Guan ,&nbsp;Xin Yu ,&nbsp;Christoph U. Correll","doi":"10.1016/j.jad.2024.11.037","DOIUrl":"10.1016/j.jad.2024.11.037","url":null,"abstract":"<div><h3>Background</h3><div>Bipolar disorder (BD) is a chronic, severe mental illness with a significant socio-economic burden. The early recognition of BD requires reliable and valid instruments.</div></div><div><h3>Objective</h3><div>We evaluated the psychometric attributes of the Bipolar Prodrome Symptom Interview and Scale-Full Prospective (BPSS-FP)-Chinese version.</div></div><div><h3>Methods</h3><div>Altogether, 129 participants, aged 16–35 years meeting DSM-5 criteria for major depressive disorder (MDD, <em>n</em> = 27) or BD (<em>n</em> = 76), and 26 healthy controls were recruited. Subjects were evaluated with the BPSS-FP Chinese version, Young Mania Rating Scale (YMRS), Montgomery-Asberg Depression Rating Scale (MADRS), and Cyclothymic–Hypersensitive Temperament questionnaire (CHT). Internal consistency, interrater reliability, criterion validity, and discriminant validity of the BPSS-FP-Chinese version were assessed.</div></div><div><h3>Results</h3><div>Cronbach alpha indices were 0.87, 0.86, and 0.66 for the manic, depressive, and general subscales of BPSS-FP-Chinese version, respectively. Interrater correlation was high, with total agreements of 0.94, 0.95, and 0.94 for the manic, depressive, and general index, respectively. Significant correlations (<em>r</em> ≥ 0.50) were noted between the BPSS-FP manic subscale and both the YMRS and CHT, the depressive subscale and the MADRS, and the general symptom subscale and the CHT. Moderate correlations were detected between the BPSS-FP general symptoms and both the YMRS and CHT (<em>r</em> = 0.40 ∼ &lt;0.50). Furthermore, the BPSS-FP mania index demonstrated a moderate correlation with the MADRS, while the depression index had a small correlation with the YMRS (<em>r</em> = 0.10 ∼ &lt;0.40).</div></div><div><h3>Conclusions</h3><div>The BPSS-FP-Chinese version has good psychometric properties and can be applied in both clinical and research settings for screening subjects with a risk for BD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"370 ","pages":"Pages 532-537"},"PeriodicalIF":4.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affects, dissociative symptoms and addictive behaviours: Insights from clinical and non-clinical samples","authors":"Elisa Renner ,&nbsp;Raphael Wimmer ,&nbsp;Zoe Zipper ,&nbsp;Hannah Brössler ,&nbsp;Jasmin Brouschek ,&nbsp;Jürgen Fuchshuber ,&nbsp;Wolfgang Beiglböck ,&nbsp;Human-Friedrich Unterrainer","doi":"10.1016/j.jad.2024.11.031","DOIUrl":"10.1016/j.jad.2024.11.031","url":null,"abstract":"<div><h3>Objectives</h3><div>Current literature links substance abuse with primary emotions and dissociative symptoms, but little research combines these relationships. This study investigates the clinical significance of these concepts and the mediating role of dissociative symptoms in the relationship between primary emotions and substance abuse.</div></div><div><h3>Methods</h3><div>Study 1 included 517 adults (77.6 % female, Age: M = 27.84) from the community. Path analysis examined the relationships between primary emotions (BANPS-GL), dissociative symptoms (FDS), psychopathology (BSI-18), and substance abuse (WHO-ASSIST). Study 2 involved 73 inpatients with substance use disorders (SUD) compared to 73 matched individuals from the general population, totalling 146 participants (21.9 % female, Age: M = 34.90). MANOVA and Discriminant analysis assessed the differences and contributions of the variables to group separation.</div></div><div><h3>Results</h3><div>Significant correlations were found between the FDS and the WHO-ASSIST, all BSI-scales, and all primary emotions except SEEKING. The FDS was a key mediator between primary emotions and substance abuse (WHO-ASSIST) and effectively differentiated between the clinical and general population groups.</div></div><div><h3>Conclusions</h3><div>These findings highlight the role of dissociative symptoms in the relationship between emotional experiences and addictive behaviour. Future research should consider dissociative symptoms in the prevention and treatment of addictive disorders.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"370 ","pages":"Pages 481-488"},"PeriodicalIF":4.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping punishment avoidance learning deficits in non-suicidal self-injury in young adults with and without borderline personality disorder: An fMRI study","authors":"Stella Nicolaou ,&nbsp;Juan Carlos Pascual ,&nbsp;Joaquim Soler ,&nbsp;Gregori Ortega ,&nbsp;Josep Marco-Pallarés ,&nbsp;Daniel Vega","doi":"10.1016/j.jad.2024.11.026","DOIUrl":"10.1016/j.jad.2024.11.026","url":null,"abstract":"<div><h3>Introduction</h3><div>Non-suicidal self-injury (NSSI) is a growing public health concern among young adults in both clinical and non-clinical settings. Despite evidence linking NSSI to alterations in learning from reward and punishment, this area remains understudied, especially in non-clinical populations without borderline personality disorder (BPD).</div></div><div><h3>Methods</h3><div>We employed a modified version of the Probabilistic Stimulus Selection (PSS) task in two groups of young adults with recurrent NSSI, with (NSSI+BPD) and without BPD (NSSI), and an additional group of healthy controls (HC). While undergoing functional magnetic resonance imaging (fMRI), participants were asked to choose between pairs of stimuli with different reward probabilities. In the training phase, they received probabilistic feedback and learned to identify the most rewarding option within fixed pairs. In the test phase, these learned stimuli were recombined into novel pairs, where participants' accuracy in selecting the most rewarding and avoiding the most punishing options reflected their ability to learn from reward and punishment, respectively.</div></div><div><h3>Results</h3><div>Compared to HC, participants in the NSSI and NSSI+BPD groups were less accurate at avoiding the most punishing options than at choosing the most rewarding options, and showed reduced activity in the nucleus accumbens (NAcc) during punishment avoidance relative to reward selection.</div></div><div><h3>Limitations</h3><div>The modest sample size, descriptive rather than modeling approach, and absence of ecological momentary assessments may limit the results.</div></div><div><h3>Conclusion</h3><div>Findings suggest that reduced activation of the NAcc when avoiding loss may underlie difficulties in learning to avoid punishment in young adults with NSSI, regardless of the presence of BPD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"370 ","pages":"Pages 489-498"},"PeriodicalIF":4.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the insula in rTMS response for depression","authors":"Chien-Lin Wu ,&nbsp;Tsung-Hua Lu ,&nbsp;Wei Hung Chang ,&nbsp;Tzu-Yun Wang ,&nbsp;Huai-Hsuan Tseng ,&nbsp;Yen Kuang Yang ,&nbsp;Po See Chen","doi":"10.1016/j.jad.2024.11.043","DOIUrl":"10.1016/j.jad.2024.11.043","url":null,"abstract":"<div><h3>Background</h3><div>The insula has a significant impact on interoception and depression. This study aims to explore the role of the insula in mediating treatment responses to high-frequency repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (DLPFC).</div></div><div><h3>Methods</h3><div>Twenty-five patients with either bipolar disorder (BD, <em>n</em> = 15) or major depressive disorder (MDD, <em>n</em> = 10) were recruited. All subjects were aged between 20 and 70, with a minimum score of 18 on the 24-item Hamilton Rating Scale for Depression (HDRS-24). Each patient received 12 sessions of rTMS treatment using a figure-eight-shaped coil at 10 Hz high-frequency stimulation intensity, targeted to the left DLPFC. Resting-state functional magnetic resonance imaging was conducted before and after the rTMS treatment to assess changes in insula-seeded functional connectivity.</div></div><div><h3>Results</h3><div>Both BD and MDD patients experienced significant reductions in depressive symptoms following rTMS therapy. The respective response rates at weeks 4, 8 and 12 were 64.0 %, 64.0 % and 68.0 % and remission rates were 40.0 %, 36.0 % and 44.0 %. Decreases in functional connectivity between the right anterior insula and right calcarine were significantly larger in the remitters than in the non-remitters (<em>p</em> = 0.013). Additionally, a higher baseline functional connectivity between the right anterior insula and right superior temporal gyrus correlated with better treatment outcome.</div></div><div><h3>Limitations</h3><div>The small sample size of 25 participants is small.</div></div><div><h3>Conclusion</h3><div>Our findings highlight the potential role of the insula in depression and suggest that insula-seeded functional connectivity could serve as a predictive biomarker for rTMS efficacy.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"370 ","pages":"Pages 538-546"},"PeriodicalIF":4.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who transitions to bipolar disorder? A comparison of major depressive disorder, anxiety, and ADHD.","authors":"Kevin Li, Katrina M Rodriguez, Peter Zandi, Fernando S Goes","doi":"10.1016/j.jad.2024.11.032","DOIUrl":"10.1016/j.jad.2024.11.032","url":null,"abstract":"<p><strong>Background: </strong>Diagnostic delays in Bipolar Disorder (BD) are common and may contribute to worse outcomes. While most studies focus on depression as a primary precursor, both anxiety and attention deficit disorders are also frequent initial diagnoses. In the current study, we utilized a large, diverse electronic health record (EHR) dataset to quantify the rates and correlates of conversion to BD from these major precursor diagnoses.</p><p><strong>Methods: </strong>Our study analyzed a comprehensive ten-year EHR dataset from Johns Hopkins Medicine, a diverse urban medical center, to assess and compare the rates and correlates of conversion to BD from Major Depressive Disorder (MDD), anxiety disorders, and ADHD. Risk factors for transition were assessed as time-varying variables in proportional hazards models.</p><p><strong>Results: </strong>Of the 21,341 patients initially included, 1232 later transitioned to a diagnosis of BD. Adjusted-one-year conversion rates for patients with MDD, anxiety disorders, and ADHD were 4.2 %, 3.4 %, and 4.0 %, respectively, with ten-year rates at 11.4 %, 9.4 %, and 10.9 %, respectively. Age (19-29 years), treatment setting (emergency and inpatient), and psychotropic medications were associated with conversion to BD across all precursor diagnoses. Severe and psychotic forms of MDD were among the strongest risk factors for transitioning to BD. Although risk factors for convertion were similar, transition rates were lower in children, particularly in indivudals with ADHD, who showed a higher rate of BD conversion in adults.</p><p><strong>Conclusions: </strong>The highest risk of transitioning to BD was observed in patients initially diagnosed with MDD, though significant risk was also noted in those with initial diagnoses of anxiety disorders and adult ADHD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"6-12"},"PeriodicalIF":4.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between post-traumatic stress disorder and neurological disorders: A genetic correlation and Mendelian randomization study","authors":"Mingxi Li ,&nbsp;Kang Qu ,&nbsp;Yueyuan Wang ,&nbsp;Yongchun Wang ,&nbsp;Yanxin Shen ,&nbsp;Li Sun","doi":"10.1016/j.jad.2024.11.044","DOIUrl":"10.1016/j.jad.2024.11.044","url":null,"abstract":"<div><h3>Background</h3><div>Observational studies have reported a close relationship between post-traumatic stress disorder (PTSD) and neurological disorders, but the existence of a causal link remains uncertain. The aim of this study is to investigate these relationships and potential mediators via Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>We sourced pooled data for genome-wide association study (GWAS) of PTSD (<em>n</em> = 1,222,882) from the psychiatric genomics consortium. Summary-level data for eight neurological traits were derived from large-scale GWASs. Genetic correlations were computed using linkage disequilibrium (LD) score regression. The inverse variance weighted (IVW) method served as the primary analysis method for MR. We employed a range of sensitivity analysis methods to ensure result robustness. A two-step approach was utilized to ascertain the effects and proportions of mediations.</div></div><div><h3>Results</h3><div>We identified significant genetic associations between PTSD and any dementia, cognitive performance, multiple sclerosis, and migraine. MR analysis revealed a significant association between PTSD and an increased risk of migraine (<em>P</em> = 0.02). This was substantiated by the results of several sensitivity analyses. Notably, the robust association between PTSD and migraine persisted even after adjustment for major depressive disorder and anxiety. Mediation analysis revealed that both alcohol intake frequency and insomnia partially mediated the association between PTSD and migraine.</div></div><div><h3>Limitations</h3><div>Participants in the MR analysis were of European descent, and verification in other ethnicities was not possible due to data limitations.</div></div><div><h3>Conclusion</h3><div>Our findings indicate a close association between PTSD and migraine. Alcohol intake frequency and insomnia serve as intermediate factors, partially explaining the relationship between PTSD and migraine.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"370 ","pages":"Pages 547-556"},"PeriodicalIF":4.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frailty and common psychiatric disorders: A bidirectional Mendelian randomization study.","authors":"Hui Xiao, Wu Zhu, Danrong Jing","doi":"10.1016/j.jad.2024.11.041","DOIUrl":"10.1016/j.jad.2024.11.041","url":null,"abstract":"<p><strong>Background: </strong>There is growing interest in exploring the relationship between frailty and common psychiatric disorders. However, there have been limited reports on the genetic variation level of frailty with psychiatric disorders.</p><p><strong>Method: </strong>We conducted large-scale Two-sample Mendelian randomization (MR) analyses to examine whether there is an association between frailty and common psychiatric disorders (bipolar disorder [BD], major depressive disorder [MDD], schizophrenia, and suicide or other Intentional self-harm). We employed multiple MR approaches to conduct the MR analysis, including MR-Egger, weighted median, and random-effect inverse variance weighted (IVW). The IVW method served as the primary analysis. Heterogeneity testing and sensitivity analysis were also conducted in the MR study.</p><p><strong>Results: </strong>The MR results denoted that frailty was associated with an increased risk of BD (odds ratio (OR) =1.60, P_IVW = 0.017), MDD (OR = 2.04, P_IVW < 0.001), schizophrenia (OR = 1.91, P_IVW = 0.005), and suicide or other Intentional self-harm (OR = 1.77, P_IVW < 0.001). For reverse analysis, we observed no significant association between psychiatric disorders and the risk of frailty. These results remained consistent across sensitivity assessments.</p><p><strong>Conclusions: </strong>Our research indicates a potential unidirectional causal relationship, suggesting that frailty may serve as a risk factor for certain common psychiatric disorders. These findings carry important for implications for psychiatric disorders and frailty patient care.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1-5"},"PeriodicalIF":4.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms of depression, but not PTSD, influence cognitive performance in healthy Army National Guard Soldiers.","authors":"Caitlin Ridgewell, Ashley Donovan, Caitlin Haven, Susan P Proctor, Kristin J Heaton","doi":"10.1016/j.jad.2024.11.038","DOIUrl":"https://doi.org/10.1016/j.jad.2024.11.038","url":null,"abstract":"<p><strong>Introduction: </strong>Research suggests that comorbid depression and PTSD may contribute to cognitive impairment. However, few studies have explored this dynamic in military personnel who report only subclinical symptoms of PTSD and depression.</p><p><strong>Methods: </strong>Army National Guard Soldiers (ARNG; N = 1415) completed the Automated Neuropsychological Assessment Metrics (ANAM), the PTSD Checklist (PCL), and the Center for Epidemiological Studies Depression Scale (CES-D). The effects of PTSD and depression symptoms on ANAM performance were examined using multiple linear regression analyses. Exploratory factor analysis and regression models examined the relationship between symptom clusters and ANAM performance.</p><p><strong>Results: </strong>Six factors were identified: avoidance/flashbacks, cognitive/social difficulty, depressed mood, positive mood, sleep difficulty, and hypervigilance. Elevated symptoms of depression (measured using factor scores) were associated with poorer attention (β range -0.19-0.18, p range < 0.01-0.04, f² effect size range 0.02-0.94).</p><p><strong>Conclusion: </strong>Depression symptoms were associated with diminished attentional performance in a large sample of ARNG Soldiers who reported no clinical diagnosis. This study was limited in that unmeasured factors other than depression, PTSD, or demographics may explain much of the variance in cognitive performance. These findings highlight the importance of careful mental health screening and strategies to heighten awareness of the potential detrimental effects of depression and PTSD on health and performance.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}