Journal of affective disorders最新文献

{"title":"Effects of skin-to-skin contact on mental health outcomes in the parents of full-term newborns: A systematic review and meta-analysis of randomized clinical trials.","authors":"Liz Mendoza-Aucaruri, Jean Pierre López-Mesia, Luis Ttito-Paricahua, Marlene Magallanes-Corimanya, Evelyn M Asencios-Falcón, Alicia Lopez-Gomero, Daniel Fernandez-Guzman, Alvaro Taype-Rondan","doi":"10.1016/j.jad.2024.10.065","DOIUrl":"10.1016/j.jad.2024.10.065","url":null,"abstract":"<p><strong>Background: </strong>The postpartum period can be emotionally challenging for parents, with documented levels of anxiety, stress, and depression. While the benefits of skin-to-skin contact (SSC) are well-known, its impact on the mental health of parents of full-term newborns has been less studied.</p><p><strong>Objective: </strong>We aimed to assess the effects of SSC in mental health outcomes in the parents of full-term newborns.</p><p><strong>Methods: </strong>In this systematic review, a comprehensive search was conducted to identify randomized clinical trials (RCTs) comparing SSC versus no SSC and assessing mental health outcomes. Meta-analyses were performed whenever possible, and the GRADE approach was used to rate the certainty of evidence.</p><p><strong>Results: </strong>We included 9 RCTs with 1201 participants. Regarding the risk of bias, the most affected domains were selective reporting, blinding, and allocation concealment. Regarding parental anxiety, SSC may reduce it at short-term, while it is unsure its effect at mid-term and it may not have any effect at long-term. Regarding Psychological stress, SSC may not have an impact at mid- and long-term. Regarding delivery-related post-traumatic stress symptoms, SSC may not have an impact at short-, mid-, and long-term. Regarding depressive symptoms, the evidence is uncertain at short- and mid-term.</p><p><strong>Limitations: </strong>For the assessed outcomes, certainty of the evidence was low or very low.</p><p><strong>Conclusion: </strong>SSC may reduce parental anxiety at short-term, while it may not have an impact in psychological stress and delivery-related post-traumatic stress symptoms. Moreover, the evidence is uncertain regarding its effect in long-term anxiety and depressive symptoms.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1090-1098"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring causal association between functional/structural connectivity and major depression disorder: A bidirectional Mendelian randomization study.","authors":"Huacong Liu, Zhenyi Lai, Yumeng Huang, Zhaoxing Liu, Ying Liu, Xiaowen Cai, Shengtao Huang, Junqi Chen, Yong Huang","doi":"10.1016/j.jad.2024.10.091","DOIUrl":"10.1016/j.jad.2024.10.091","url":null,"abstract":"<p><strong>Objectives: </strong>Prior observational studies have suggested a correlation between major depressive disorder (MDD) and communication imbalances within the resting-state brain network (RSN), but the causal relationship remains unclear. This research uses Mendelian randomization (MR) analysis to explore the potential causal effects between functional connectivity (FC), structural connectivity (SC) and MDD.</p><p><strong>Methods: </strong>Two-sample bidirectional MR analysis was employed in this study. Inverse variance weighted (IVW) was used to explore the causal relationship between the FC/SC and MDD, with various methods such as MR-Egger to conduct sensitivity analyses.</p><p><strong>Results: </strong>The IVW analysis results showed that higher genetic predicted dorsal attention network FC, limbic network SC, and dorsal attention network SC were associated with an increased risk of MDD (β: 15.08, 95%CI: 5.89-24.27, p = 0.001; β: 3.79, 95%CI: -0.22-7.8, p = 0.034; β: 9.89, 95%CI: 0.88-18.90, p = 0.031). Reverse MR analysis demonstrated that a genetically predicted elevated risk of MDD was associated with reduced frontal parietal network FC (β: -0.00046, p = 0.041).</p><p><strong>Conclusions: </strong>The study suggests a causal relationship between the FC and SC within specific RSNs and the risk of MDD. Abnormalities in the dorsal attention network FC/SC and the limbic network SC were risk factors for MDD. The FC abnormality of the frontal parietal network may be the downstream influence following the MDD onset. Further investigation is needed to determine the potential utility of these neuroimaging markers in the prevention of MDD or the evaluation of treatment efficacy.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1064-1070"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of adverse childhood experiences on adult physical, mental health, and abuse behaviors: A sex-stratified nationwide latent class analysis in Japan.","authors":"Takahiro Hirai, Kosuke Hagiwara, Chong Chen, Ryo Okubo, Fumihiro Higuchi, Toshio Matsubara, Masahito Takahashi, Shin Nakagawa, Takahiro Tabuchi","doi":"10.1016/j.jad.2024.10.074","DOIUrl":"10.1016/j.jad.2024.10.074","url":null,"abstract":"<p><p>Adverse childhood experiences (ACEs) have been reported to detrimentally impact physical and mental health. While experiencing multiple ACEs is common, previous research primarily assessed ACEs by their total count, neglecting the impacts of different experience types. Furthermore, sex-based differences in ACEs and their influences remain unclear. This study employed Latent Class Analysis (LCA) to uncover patterns of ACEs with consideration for sex differences, aiming to elucidate their effects on adult physical and mental health. A geographically nationally representative dataset from the \"Japan COVID-19 and Society Internet Study (JACSIS)\" conducted in 2022 was used. 13,715 men and 14,327 women retrospectively reported their experiences across fifteen ACEs. The analysis revealed four distinct ACE patterns for both sexes: a Multiple Adversities class with a wide range of severe ACEs, a Psychological Abuse class experiencing emotional abuse at home and bullying at school, a Poverty class facing economic hardships, and a Low Adversities class with the fewest ACEs. Multinomial logistic regression analysis indicated that more severe patterns of exposure correlated with heightened adverse adult outcomes. However, the extent of these impacts varied by sex and ACE pattern. For instance, men in Multiple Adversities and Psychological Abuse classes exhibited higher tendencies towards conducting physical and psychological abuse behaviors. While ACEs in men were linked to both underweight (in cases of psychological abuse) and obesity (across all classes), women with ACEs generally leaned towards higher body weight. These findings highlight the importance of developing support strategies sensitive to sex differences and the specific content of ACEs.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1071-1081"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between rest-activity/light-exposure rhythm characteristics and depression in United States adults: A population-based study.","authors":"Yundan Liao, Wei Zhang, Shixue Chen, Xiaoxu Wu, Keyi He, Maoyang Wang, Yuanqi Lan, Fang Qi","doi":"10.1016/j.jad.2024.10.073","DOIUrl":"10.1016/j.jad.2024.10.073","url":null,"abstract":"<p><p>This cross-sectional study investigated the association between 24-hour rest-activity rhythm (RAR), light exposure rhythm (LER), and depression symptoms in American adults, using data from the National Health and Nutrition Examination Survey (2011-2014, N = 6852). RAR and LER characteristics were derived from a 24-hour activity recorder and analyzed using the extended cosine model, focusing on intradaily variability (IV), interdaily stability (IS), and relative amplitude (RA). Depression was assessed via the Patient Health Questionnaire-9 (PHQ-9).Multiple logistic and linear regression models showed that higher IV in RAR and LER were associated with increased depression risk (RAR-IV OR = 1.92 [95 % CI: 0.89-4.13]; LER-IV OR = 2.5 [1.45-4.30]), while higher IS and RA in both rhythms were linked to lower depression risk (RAR-IS OR = 0.22 [0.10-0.48], RAR-RA OR = 0.20 [0.11-0.37], LER-IS OR = 0.22 [0.10-0.49], LER-RA OR = 0.29 [0.15-0.56]). Participants in the highest tertile for IS and RA had a significantly lower depression risk compared to the lowest tertile. Subgroup analyses indicated interactions between age and RAR-IV, gender and LER-IV, and BMI and LER-RA (p-interaction < 0.05). Disruptions in RAR and LER are positively associated with depression, emphasizing the need for rhythm regulation interventions considering age, gender, and BMI factors.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1004-1012"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms are linked to age-specific neuroanatomical and cognitive variations.","authors":"Eyal Bergmann, Daniel Harlev, Noham Wolpe","doi":"10.1016/j.jad.2024.10.077","DOIUrl":"10.1016/j.jad.2024.10.077","url":null,"abstract":"<p><p>Depression is a heterogeneous disorder, both in terms of patient symptomatology and in patient sociodemographic factors. Here, we examine the contribution of age to this heterogeneity, by characterizing the associations of depressive symptoms with cognitive performance and brain structure across the lifespan. We analyzed data from the Cambridge Centre for Aging Neuroscience (Cam-CAN) cohort (N = 2591, age 18-99). A subset of this cohort (N = 647) underwent structural MRI. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale. Cognitive assessments were performed using The Addenbrooke's Cognitive Examination Revised. Generalized linear models were employed to examine the relationship between depressive symptoms and cognitive performance. Statistical parametric mapping explored age-dependent associations between depressive symptoms and grey matter volume. Cognitive performance was associated with a significant age by depression by cognitive domain interaction, indicating that older individuals with more depressive symptoms had a lower cognitive performance, particularly in the fluency domain. Structural MRI revealed preferential depression-related reduction in grey matter volume in the left and right hippocampi in older adults. By contrast, in younger adults, depressive symptoms were more strongly associated with grey matter volume reduction in the left superior frontal gyrus and left middle frontal gyrus. Collectively, these findings indicate that the associations of depression with cognitive performance and brain structure are age-dependent, suggesting that the pathophysiological mechanisms underlying depression may differ between young and older adults. Recognizing these differences will support the development of better diagnostic tools and therapeutic interventions for depression across the lifespan.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1013-1020"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences and risk of suicide and substance-related mortality through middle adulthood.","authors":"Theemeshni Govender, Pablo Vidal-Ribas, Jing Yu, Denise L Haynie, Diana Augustin, Stephen E Gilman","doi":"10.1016/j.jad.2024.10.085","DOIUrl":"10.1016/j.jad.2024.10.085","url":null,"abstract":"<p><strong>Background: </strong>Few studies have prospectively examined whether adverse childhood experiences contribute to suicide or substance-related mortality. Moreover, children are often exposed to multiple adversities making it critical to identify which clusters of adversities are most harmful for these outcomes. Accordingly, we investigated risk for suicide and substance-related mortality based on the number and clusters of adversities children were exposed to.</p><p><strong>Methods: </strong>Identifying information from 49,853 offspring born between 1959 and 1966 to participants in the Collaborative Perinatal Project was linked to the National Death Index to determine vital status by the end of 2016. We examined associations of the total number of adversities and five clusters of adversity (Low Adversity, Parental Harshness & Neglect, Family Instability, Poverty & Crowded Housing, Poverty & Parental Separation) with suicide and substance-related mortality.</p><p><strong>Results: </strong>Of the 45,207 participants in the analysis sample, 267 died by suicide and 338 by substance use. Participants who experienced Family Instability had a higher risk of dying by suicide (hazard ratio [HR] = 1.92, 95% CI: 1.32, 2.79) and substance use (HR = 1.50, 95% CI: 1.02, 2.19). Participants who experienced Poverty & Parental Separation were at higher risk of dying by substance use (HR = 1.85, 95% CI: 1.40, 2.45).</p><p><strong>Limitations: </strong>Adversities with documented harm including physical and sexual abuse were not assessed in the study.</p><p><strong>Conclusions: </strong>Childhood adversity is associated with multiple types of self-injury mortality, suggesting shared etiology of risk for suicide and substance-related mortality. Research on interventions that target shared pathways linking childhood vulnerability to multiple causes of death may help reduce the long-term impact of adversities.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1201-1208"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brooding, reflection, and anger rumination in late life suicidal behavior.","authors":"Morgan Buerke, Alexandra Khani, Hanga Galfalvy, Meghan T Wong, Katalin Szanto","doi":"10.1016/j.jad.2024.10.093","DOIUrl":"10.1016/j.jad.2024.10.093","url":null,"abstract":"<p><strong>Background: </strong>Current literature on age-specific risk factors for suicide in older adulthood is lacking. One risk factor for younger-life suicide, rumination, has not been extensively studied in older adults, but from prior research, may be more relevant to late-life vs. early life suicide. The current study investigated how multiple subtypes of rumination (i.e., brooding, reflection, and anger rumination) relate to suicidal ideation and recent suicidal behavior in late life.</p><p><strong>Methods: </strong>378 participants aged 50-90 (mean age 63.4, SD 7.5) were recruited into a case-control study examining suicide in older adults. Participants were recruited into three groups: 1) depressed adults who had made a recent (past two years) suicide attempt, 2) those with depression but no suicide attempt, and 3) a healthy comparison group. Among depressed groups, we examined relationships between rumination types, trait anger, depression, and suicidal ideation. Then, we conducted logistic regression to test which variables were related to having made a suicide attempt in the past two years among those with current suicidal ideation.</p><p><strong>Results: </strong>All forms of rumination were related to depression. Brooding was related to ideation severity, but only depression severity related to presence of ideation. Anger rumination and ideation severity each contributed unique variance in their prediction of recent suicide attempts.</p><p><strong>Limitations: </strong>Our cross-section design does not allow for causal claims; future studies should consider using ecological momentary assessment approaches.</p><p><strong>Conclusions: </strong>Treatments to decrease rumination without an intense cognitive component should be considered for late-life patients.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"963-969"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional changes in depressive symptoms and social functioning in older adults attending psychological therapy services.","authors":"Thomas Steare, Joshua E J Buckman, Joshua Stott, Amber John, Satwant Singh, Jon Wheatley, Stephen Pilling, Rob Saunders","doi":"10.1016/j.jad.2024.10.098","DOIUrl":"10.1016/j.jad.2024.10.098","url":null,"abstract":"<p><strong>Background: </strong>Impairments in the ability to carry out social activities commonly co-occur alongside depression. Improving social functioning is often overlooked in treatment. This is despite the high value placed by patients on social functioning and the potential for interventions focused on social functioning to have additional benefits in reducing depressive symptoms. In older adults the relationship between depressive symptoms and social functioning during treatment is poorly understood.</p><p><strong>Methods: </strong>We analysed data across the first four treatment sessions of 3260 older adults receiving psychological therapy for depression at eight NHS Talking Therapies for anxiety and depression services in England. Random-intercept cross-lagged panel models were estimated, modelling bi-directional change between depressive symptoms, and impairments in (a) social leisure activities, and (b) close relationships, controlling for gender and diagnosis.</p><p><strong>Results: </strong>Over treatment sessions, depressive symptoms and impairments in social functioning decreased. A bi-directional relationship was observed whereby depressive symptoms were associated with future impairments in social functioning and vice versa. Changes in depressive symptoms appeared to have a greater association with future social functioning, compared to the reverse.</p><p><strong>Limitations: </strong>Patients lived in Greater London and findings may not translate to other settings. We included older adults that attended at least four treatment sessions, and had no missing data at the first assessment, potentially biasing the sample and results.</p><p><strong>Conclusions: </strong>Older adults receiving psychological therapy experience reductions in depressive symptoms and impairment in social functioning early in treatment. Treating core depressive symptoms and impairments in social functioning may benefit one another, and improve outcomes.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"369 ","pages":"954-962"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accumulation of perceived discrimination over time and likelihood of probable mental health problems in UK adults: A longitudinal cohort study.","authors":"Rosanna May Maletta, Michael Daly, Rob Noonan, I Gusti Ngurah Edi Putra, Victoria Vass, Eric Robinson","doi":"10.1016/j.jad.2024.09.128","DOIUrl":"10.1016/j.jad.2024.09.128","url":null,"abstract":"<p><strong>Background: </strong>Limited research has examined whether accumulation of discrimination over time is associated with worse mental health and whether such experiences are related to socioeconomic status (SES).</p><p><strong>Methods: </strong>A sample of UK adults with self-reported discrimination experiences (n = 3863) was taken from three waves of the UK Household Longitudinal Study (2015-2020). Multinomial logistic regression assessed associations between SES (income, education, occupation) and cumulative discrimination (number of timepoints discrimination was reported). Logistic regression models assessed prospective associations between cumulative discrimination and probable mental health problems (GHQ-12; 4+ threshold).</p><p><strong>Results: </strong>Those with lower income were more likely to report discrimination at one timepoint (vs. none). No SES measures were associated with experiencing discrimination at multiple timepoints. Participants who reported one timepoint of discrimination (vs. no experiences) were significantly more likely to report probable mental health problems (OR = 1.47, p < .001, 95% CI 1.20-1.80). Moreover, compared to those experiencing one timepoint, participants reporting multiple timepoints of discrimination were significantly more likely to report probable mental health problems (OR = 1.46, p = .002, 95% CI 1.15-1.86), indicating a cumulative association between discrimination and mental health. There was limited evidence that SES moderated this cumulative association.</p><p><strong>Limitations: </strong>Mental health measures were based on self-report questionnaires and not a clinical diagnosis.</p><p><strong>Conclusions: </strong>Amongst a sample of UK adults, perceiving discrimination at multiple timepoints increased the likelihood of experiencing probable mental health problems. There was limited evidence that this cumulative association differed by SES. National measures designed to reduce discrimination may benefit mental health.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"913-921"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the pathways from adverse childhood experiences to substance use.","authors":"Sunday Azagba, Todd Ebling, Alperen Korkmaz","doi":"10.1016/j.jad.2024.10.090","DOIUrl":"10.1016/j.jad.2024.10.090","url":null,"abstract":"<p><strong>Background: </strong>Adverse childhood experiences (ACEs) are traumatic events that occur early in life and can have lasting effects on health and well-being. Previous research has linked ACEs to substance use in adulthood, but there is limited research on the underlying mechanisms or pathways of this relationship. This study explores whether depression mediates the relationship between ACEs and current substance use among U.S. adults.</p><p><strong>Methods: </strong>Data were obtained from the 2021 Behavioral Risk Factor Surveillance System (n = 30,978). Generalized Structural Equation Modeling was used to examine the links between ACEs, cigarette, e-cigarette, and marijuana use while adjusting for sociodemographic characteristics.</p><p><strong>Results: </strong>Approximately 71 % of respondents reported experiencing at least one ACE. The findings show that depressive disorders mediate the relationship between ACEs and current substance use among U.S. adults. There was a significant indirect effect of ACEs on current cigarette use (OR = 1.13, 95 % CI [1.10, 1.16]), e-cigarette use (OR = 1.17, 95 % CI [1.12-1.22]), and marijuana use (OR = 1.22, 95 % CI [1.13, 1.33]) through the mediator of depressive disorders. Additionally, the most pronounced effects were found among those aged 18-24 years for cigarette use (OR = 1.32, 95 % CI [1.11, 1.56]), e-cigarette use (OR = 1.22 [1.09, 1.36]), and especially marijuana use (OR = 1.52 [1.18, 1.96]).</p><p><strong>Conclusion: </strong>These findings suggest that depression may be a key pathway from negative experiences during childhood to certain types of substance use in adulthood, particularly among young adults.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"1209-1214"},"PeriodicalIF":4.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}