Journal of affective disorders最新文献

{"title":"Instability of SUCRA, heterogeneity and concerns about evidence confidence: Questioning the claimed superiority of navigated TMS","authors":"Itsuki Terao","doi":"10.1016/j.jad.2025.119961","DOIUrl":"10.1016/j.jad.2025.119961","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119961"},"PeriodicalIF":4.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subthreshold and probable full-syndrome body dysmorphic disorder among medical and dental students in Bangladesh: A cross-sectional study","authors":"Ruksana Sharmin Swarna ,&nbsp;Mridul Kanti Roy ,&nbsp;Mariam Zamila ,&nbsp;Farzana Rahman ,&nbsp;Md. Farhan Ibne Faruq ,&nbsp;Taposhee Rabeya Rahman Zenith ,&nbsp;Rinku Das ,&nbsp;Imteaz Mahmud ,&nbsp;Mohammad Delwer Hossain Hawlader","doi":"10.1016/j.jad.2025.119956","DOIUrl":"10.1016/j.jad.2025.119956","url":null,"abstract":"<div><h3>Background</h3><div>Body dysmorphic disorder (BDD) is a psychiatric condition predominantly affecting teenagers and young adults, characterized by clinically significant impairments in social, academic, and functional domains. We aimed to explore the prevalence and correlates of subthreshold and probable full-syndrome BDD among Bangladeshi medical and dental students.</div></div><div><h3>Methods</h3><div>An institution-based cross-sectional study was conducted from January to May 2024, in two medical and two dental colleges located in Dhaka division, Bangladesh, and affiliated with the University of Dhaka. Among 361 undergraduate students, the BDD questionnaire (BDDQ) screened subthreshold and probable BDD; and two multivariate binary logistic regression models identified some important academic, sociodemographic, and lifestyle-related correlates of these conditions.</div></div><div><h3>Results</h3><div>13.3 % and 5.8 % of the participants were screened as having subthreshold BDD and probable BDD, respectively. Being a dental student (AOR = 3.96; 95 % CI 1.41–11.11), being female (AOR = 4.42; 95 % CI 1.65 to 11.85), substance (tobacco and/or alcohol) use (AOR = 2.33; 95 % CI 1.05–5.19), physical exercise (AOR = 2.67; 95 % CI 1.05–6.75), and using social media for &gt;3 h daily (AOR = 4.34; 95 % CI 1.07–11.07) were associated with increased odds of having at least subthreshold BDD, while being normal weight exhibited decreased odds (AOR = 0.20; 95 % CI 0.06–0.67). Being female (AOR = 1.83; 95 % CI 1.30–24.02) and substance use (AOR = 3.73; 95 % CI 1.32–10.53) were associated with higher odds of having probable BDD.</div></div><div><h3>Conclusion</h3><div>This study accentuates the need for targeted interventions to facilitate body image perception-oriented psychological wellness among future healthcare professionals.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119956"},"PeriodicalIF":4.9,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stopping suffering: An exploration of suicidal ideation and its clinical, cognitive and relational correlates among women with a diagnosis of endometriosis","authors":"Cristina Zarbo ,&nbsp;Alessandra Santona ,&nbsp;Laura Parolin ,&nbsp;Rita Secomandi ,&nbsp;Ilario Candeloro ,&nbsp;Chiara Malandrino ,&nbsp;Luigi Frigerio","doi":"10.1016/j.jad.2025.119964","DOIUrl":"10.1016/j.jad.2025.119964","url":null,"abstract":"<div><h3>Background</h3><div>Women with endometriosis are at risk for poor mental health and suicidal ideation and behaviour. This manuscript includes two studies aimed to: (i) investigate the differences in suicidal ideation (SI) frequencies between women with (EN) and without (CG) endometriosis; and (ii) identify clinical, cognitive and relational factors associated with SI in the EN group.</div></div><div><h3>Methods</h3><div>Study 1 included 171 EN and 62 CG participants, while Study 2 included 38 EN and 71 CG participants. Participants completed self-reported instruments to assess SI, pain, cognitive emotion regulation strategies, and attachment styles. Both studies included sociodemographic and clinical forms. Statistical analyses included the chi-square test and logistic hierarchical regressions.</div></div><div><h3>Results</h3><div>In both studies, about 20 % of the EN group reported SI, with a frequency of occurrence significantly higher than CG (respectively <em>p</em> = 0.03 and <em>p</em> = 0.002). EN with SI, when compared to EN without SI, showed lower health (respectively <em>p</em> = 0.018; <em>p</em> = 0.006), and higher occurrence of backache (<em>p</em> = 0.031), surgeries for endometriosis (<em>p</em> = 0.040), and lifetime abortion (<em>p</em> = 0.043). Moreover, among the EN group, higher levels of self-blame (OR = 1.36) and avoidant attachment (OR = 18.95) and lower levels of acceptance (OR = 0.68) were associated with a higher likelihood of having SI, over and above clinical variables.</div></div><div><h3>Discussion</h3><div>SI among the EN group is significantly linked to attachment insecurity and cognitive emotional regulation strategies (i.e. self-blame, acceptance), in addition to disease-related factors (i.e. pain, surgical treatments). These findings highlight the complex interplay between clinical symptoms, cognitive emotion regulation, and relational functioning and underscore the need for integrated psychological assessment and care.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119964"},"PeriodicalIF":4.9,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional habituation as a protective factor for resilience: Insights from ERP and hierarchical linear modeling","authors":"Yuntong Yang ,&nbsp;Xing Hu ,&nbsp;Nils Kohn ,&nbsp;Linlin Yan ,&nbsp;Hongxia Duan ,&nbsp;Jianhui Wu","doi":"10.1016/j.jad.2025.119965","DOIUrl":"10.1016/j.jad.2025.119965","url":null,"abstract":"<div><div>Emotional habituation, a basic form of neural plasticity, regulates emotions adaptively, yet its role in stress resilience remains unclear. This study integrated laboratory-based EEG habituation measures and ecological experience sampling to examine valence-specific habituation as a resilience factor against daily life stress in 69 undergraduates. Habituation slopes were derived from Late Positive Potential (LPP) amplitude and arousal trajectories when participants viewed repeated pictures. Daily stressors and anxiety were reported over 30 days. Hierarchical linear modeling (HLM) revealed that habituation, modeled as a between-subjects moderator, significantly buffered stress reactivity: faster habituation to unpleasant stimuli (indexed by arousal and LPP slopes) and slower habituation to pleasant stimuli (indexed exclusively by LPP slopes) predicted reduced state anxiety amid rising daily stressors. These results underscored the role of adaptive emotional habituation as a protective factor for psychological resilience, with distinct pathways for threat disengagement (unpleasant valence) and reward preservation (pleasant valence). This research offers valuable insights for developing targeted interventions to prevent stress-related disorders.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119965"},"PeriodicalIF":4.9,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological distress and vulnerability: Contrasting associations with cognitive performances based on sex and cardiovascular health.","authors":"Marie Payer, Emma Gabrielle Dupuy, Florent Besnier, Thomas Vincent, Christine Gagnon, Marie-France Marin, Louis Bherer","doi":"10.1016/j.jad.2025.119950","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119950","url":null,"abstract":"<p><p>The COVID-19 pandemic has impacted individuals diversely, leading to psychological distress, loneliness and subjective cognitive complaints. People with chronic medical conditions such as cardiovascular diseases (CVD) and those with psychological vulnerabilities were at greater risk of experiencing severe psychological consequences. Women have also reported higher levels of vulnerability and anxiety symptoms compared to men, although this difference appears to lessen with age. This combination of medical conditions, symptoms, and psychological vulnerabilities may influence cognitive aging. Using the COVID-19 pandemic as a universal stressor, this study examines how this combination relates to cognitive health in men and women aged 50 years and over. A total of 122 individuals with stable CVD (87 men, 71.3 %) and 127 healthy individuals (30 men, 23,6 %) completed neuropsychological assessments and questionnaires assessing psychological distress (stress, depression, anxiety symptoms) and psychological vulnerabilities (anxiety sensitivity, rumination, intolerance of uncertainty, and anxious traits). Among healthy participants, men with higher psychological vulnerabilities showed lower global cognitive performance (B = -2.097, p = .002) compared to their female counterparts (B = 0.022, p = .946). Lower psychological distress was associated with better executive functioning performance in individuals with CVD (B = -0.218, p = .019). These findings show evidence that among individuals over 50, psychological distress and vulnerabilities can be associated with lower cognitive performances in executive functioning and global cognitive performance respectively. However, these associations differ according to medical conditions and sex where higher psychological vulnerability among healthy men may act as a risk factor for lower global cognitive health.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119950"},"PeriodicalIF":4.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression severity self-assessment to guide relapse potential stratification during maintenance ECT.","authors":"Liselotte Gezels, Linda Van Diermen, Violette Coppens, Jean-Baptiste Belge, Liese Van den Eynde, Shauni Verspecht, Simon Lambrichts, Lennart Gistelinck, Tom Birkenhäger, Pascal Sienaert, Didier Schrijvers","doi":"10.1016/j.jad.2025.119931","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119931","url":null,"abstract":"<p><p>The severity of major depressive disorder (MDD) is crucial in guiding treatment decisions for electroconvulsive therapy (ECT), particularly given the high relapse rates post-ECT. Maintenance-ECT (M-ECT) has emerged as a key strategy to prevent relapse, with recent trends favouring symptom-driven approaches. This study explores the use of self-report scales as an adjunct to clinician-rated assessments in M-ECT decision-making, focusing on the Clinician-Rated 30-item Inventory of Depressive Symptomatology (IDS-C) and its self-report version (IDS-SR). In the Preventing Relapse After Successful ECT for Depression (PRASED) study, a subsample of 96 MDD patients were included upon achieving remission after an acute ECT course. Patients were stratified into relapse potential categories based on weekly IDS-C scores, determining the need for zero, one, or two M-ECT sessions the following week. Using five monthly IDS-C and -SR, the scales demonstrated good to excellent agreement, with intraclass correlation coefficients ranging from 0.73 to 0.85 at multiple timepoints during M-ECT. Notably, 81 % of decision-making outcomes were concordant. Also, 16 % would result in patients receiving more ECT sessions based on the IDS-SR than the IDS-C, highlighting some overestimation by self-report scores. These findings indicate that self-assessment of depression severity by IDS-SR is a reliable alternative for clinician-rated measurements during M-ECT. Hence, this reduction of resource burden by self-report could facilitate the widespread implementation of personalised M-ECT, which may improve patient outcomes by reducing relapse rates in MDD. Future research should focus on validating self-report measures as reliable alternatives to clinician assessments in M-ECT to optimize treatment personalization and efficiency.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119931"},"PeriodicalIF":4.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between adverse childhood experiences and antenatal depression among pregnant women: A computer-simulated network analysis","authors":"Xiaoxiao Mei ,&nbsp;Ranran Mei ,&nbsp;Jinzhou Yu ,&nbsp;Furong Chen ,&nbsp;Shuhan Li ,&nbsp;Minyu Liang ,&nbsp;Yuling Liu ,&nbsp;Zengjie Ye","doi":"10.1016/j.jad.2025.119960","DOIUrl":"10.1016/j.jad.2025.119960","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to investigate the differences in depressive symptoms among pregnant women with and without adverse childhood experiences (ACEs), identify distinct core and bridge symptoms of depression in both groups, and target specific symptoms for intervention.</div></div><div><h3>Methods</h3><div>A total of 2719 pregnant women were recruited from the “Be Resilient to Postpartum Depression” program. ACEs and depressive symptoms were assessed using validated scales. Data analysis was conducted using a computer-simulated network analysis approach.</div></div><div><h3>Results</h3><div>A significant positive correlation was found between the total ACEs score and depression score (<em>r</em> = 0.181, <em>P</em> &lt; 0.001). In the non-ACEs group, “I can laugh and see the funny side of things” was the core and most bridge symptoms, as well as the targeted intervention symptom for aggravating the depressive symptoms. In the ACEs group, “I feel cheerful” emerged as the core and most bridge symptoms, while “I look forward with enjoyment to things” was identified as the targeted intervention symptom for aggravating the depressive symptoms. “I still enjoy the things I used to enjoy” was recognized as a targeted symptom for alleviating depressive symptoms in both groups.</div></div><div><h3>Conclusion</h3><div>This study underscores the nuanced relationship between ACEs and antenatal depression, underscoring the need for tailored mental health interventions that consider the history of childhood adversity among pregnant women.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119960"},"PeriodicalIF":4.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental trajectories of depressive symptoms during early adolescence: A 12-month cohort study in Nanchong, China","authors":"Peng Chen ,&nbsp;Pei Jiang ,&nbsp;Yingjuan Cui ,&nbsp;Xiang Yuan ,&nbsp;Jidong Ren ,&nbsp;Jie Gong ,&nbsp;Yujia Liao ,&nbsp;Li Yuan ,&nbsp;Qiuyu Pan ,&nbsp;Huiwen Zhang ,&nbsp;Qiansan Yang ,&nbsp;Xiaobing Tian","doi":"10.1016/j.jad.2025.119941","DOIUrl":"10.1016/j.jad.2025.119941","url":null,"abstract":"<div><h3>Background</h3><div>Adolescence marks a critical period for mental health development, yet longitudinal patterns of depressive symptoms during the transition from childhood to early adolescence remain understudied. This study identifies distinct developmental trajectories of depressive symptoms in Chinese junior school students and examines their sociodemographic and behavioral predictors.</div></div><div><h3>Methods</h3><div>Using longitudinal data from 2635 seventh- to eighth-grade students in Nanchong, China (2022–2023), depressive symptoms were assessed at three six-month intervals via the Center for Epidemiologic Studies Depression Scale (CES-D). Group-based trajectory modeling (GBTM) identified latent trajectory classes, and multinomial logistic regression analyzed predictors of class membership.</div></div><div><h3>Results</h3><div>Prevalence rates of depressive symptoms increased across waves (13.40 %, 21.56 %, 26.94 %). Three trajectory classes emerged: Consistently low symptoms, namely, Low-risk (27.40 %), Persistently elevated symptoms, high-risk (28.54 %), Steeply increasing symptoms, progressing-risk (44.06 %). Female gender, left-behind status, reconstituted family structure, shorter sleep duration, prolonged screen time, and infrequent physical activity predicted membership in both high-risk (adjusted odds ratio [aOR] range: 1.4–3.2) and progressing-risk classes. Lower parental education levels were uniquely associated with the progressing-risk class (aOR = 1.27, <em>P</em> &lt; 0.05).</div></div><div><h3>Limitations</h3><div>Key limitations include the relatively short observation window, regionally restricted sampling, potential unmeasured confounders, and the inherent subjectivity of self-reported measures, which may affect the interpretation and generalizability of the findings.</div></div><div><h3>Conclusion</h3><div>Depressive symptom trajectories among adolescents in Nanchong, Sichuan Province demonstrate substantial heterogeneity, shaped by intersecting individual, familial, and behavioral factors. Early identification of high-risk subgroups and tailored interventions targeting modifiable predictors (e.g., sleep hygiene, digital overuse)—anchored to baseline risk profiles and adaptively refined through longitudinal monitoring—may mitigate mental health burdens during this vulnerable developmental window.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119941"},"PeriodicalIF":4.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized, double-blind, sham controlled clinical trial to evaluate the efficacy of electrical vestibular stimulation (VeNS) for major depressive disorder","authors":"Sai Sailesh Kumar Goothy ,&nbsp;Rohit Singh ,&nbsp;Joseph Reel ,&nbsp;Rachel Robinson ,&nbsp;Wiktoria Ratajczak ,&nbsp;Sinead Watson ,&nbsp;Jason McKeown","doi":"10.1016/j.jad.2025.119949","DOIUrl":"10.1016/j.jad.2025.119949","url":null,"abstract":"<div><h3>Aims and objectives</h3><div>Stimulating the vestibular nerve may influence neurological processes such as prefrontal cortex functions, aiding cognitive flexibility and emotional regulation, important aspects of addressing depressive patterns. This randomized, double-blind, sham-controlled trial aimed to determine the efficacy and safety of a non-invasive electrical vestibular nerve stimulation (VeNS) device as a treatment for major depressive disorder (MDD).</div></div><div><h3>Materials and methods</h3><div>62 adults (mean age = 43.1 ± 5.0 years) with MDD were randomized to receive an active VeNS device (<em>n</em> = 31) or a sham device (n = 31). Both groups attended the clinic for stimulation sessions (30 min) 5 days per week. The primary outcome was change in Beck's Depression Inventory (BDI-II) score from baseline to week 8. Secondary outcomes were change in Insomnia Severity Index (ISI), Generalized Anxiety Disorder, 7-item (GAD-7), and the EQ-5D-5L Health Utility Index (HUI) scores from baseline to week 8. A post-intervention follow-up was at week 12.</div></div><div><h3>Results</h3><div>After 8 weeks, the active group showed a mean BDI-II score reduction of 6.39 points greater than the sham group (<em>P</em> &lt; 0.001), with scores remaining low during the 4-week post-intervention follow-up. Additionally, the active group, compared with the sham group, showed a significant improvement in ISI (−6.29 vs. 2.23, <em>p</em> &lt; 0.001), GAD-7 (−4.45 vs. -0.32, p &lt; 0.001) and HUI (0.51 vs 0.11, p &lt; 0.001) One minor Adverse Event was reported in the sham group. Formal blinding assessment demonstrated a successful level of blinding was achieved throughout the study.</div></div><div><h3>Conclusion</h3><div>VeNS, when delivered over 8-weeks, appears to have a clinically meaningful benefit as an intervention for major depressive disorder.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119949"},"PeriodicalIF":4.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond impulsivity, predicting non-suicidal self-injurious behavior in adolescents: A network approach","authors":"Baihui Luo ,&nbsp;Fang Nong ,&nbsp;Bing Qi ,&nbsp;Xiaoli Liu ,&nbsp;Yuehua He ,&nbsp;Hui Zheng","doi":"10.1016/j.jad.2025.119945","DOIUrl":"10.1016/j.jad.2025.119945","url":null,"abstract":"<div><h3>Background</h3><div>Impulsivity is a key factor in the onset of non-suicidal self-injury (NSSI) during adolescence; however, the impact of other psychological factors on this relationship remains uncertain.</div></div><div><h3>Objectives</h3><div>This study mainly explored the complex network relationship between general mental health status and NSSI in adolescents.</div></div><div><h3>Methods</h3><div>We surveyed 1127 adolescents regarding their experiences with NSSI and conducted detailed assessments of their mental health status, attitudes toward animals, and demographic characteristics, including age, gender, Body Mass Index, socioeconomic status, and online-time. Complex interactions and potential patterns among NSSI, general mental health status, attitudes toward animals, and demographic variables were examined using logistic regression analysis, GLASSO network and Bayesian network analysis.</div></div><div><h3>Results</h3><div>A significant association was observed between impulsive tendencies (ImT; odds ratio [OR]: 1.62; 95 % confidence interval [CI]: 1.49–1.76) and physical symptoms (PhS; OR: 1.34, 95 % CI: 1.27–1.43) with NSSI in the training set. Network analysis identified anxiety about people (AaP), PhS, and ImT as central features. Moreover, Bayesian network analysis suggested that ImT has a direct associated with NSSI, while AaP and PhS exert an indirect influence on NSSI through the mediation of ImT.</div></div><div><h3>Conclusion</h3><div>Beyond the direct and potent link between impulsivity and non-suicidal self-injury, the study highlights that interpersonal anxiety and somatic symptoms have an indirect yet significant impact on non-suicidal self-injury, primarily mediated through the prism of impulsivity.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119945"},"PeriodicalIF":4.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}