Journal of affective disorders最新文献

{"title":"The impact of childhood emotional abuse and depressive symptoms on sleep macro-architecture and cortical thickness","authors":"Hanyi Jiang ,&nbsp;Antoine Weihs ,&nbsp;Stefan Frenzel ,&nbsp;Johanna Klinger-König ,&nbsp;Ralf Ewert ,&nbsp;Beate Stubbe ,&nbsp;Klaus Berger ,&nbsp;Thomas Penzel ,&nbsp;Ingo Fietze ,&nbsp;Robin Bülow ,&nbsp;Henry Völzke ,&nbsp;Hans J. Grabe","doi":"10.1016/j.jad.2025.02.005","DOIUrl":"10.1016/j.jad.2025.02.005","url":null,"abstract":"<div><h3>Background</h3><div>Adverse childhood events and especially emotional abuse (EA) is consistently associated with poor psychiatric outcomes in adulthood, with depressive symptoms being one of the most prevalent. Both EA and depression are frequently associated with poorer sleep quality and cortical structural abnormalities. Interestingly, some individuals who experienced early-life EA are resilient against the development of psychiatric illness in adulthood and are believed to possess distinct neurobiology that confer more effective coping mechanisms.</div></div><div><h3>Methods</h3><div>682 subjects from a population-based cohort underwent polysomnography (PSG), whole-body magnetic resonance imaging (MRI) and completed the Childhood Trauma Questionnaire (CTQ) and Patient Health Questionnaire (PHQ-9). Linear regressions were used to model joint EA and depressive symptoms effects with sleep macro-architecture and cortical thickness; and path analyses were used to investigate mediation effects.</div></div><div><h3>Results</h3><div>Considering depressive symptoms as a product variable with EA (EA×depression), we observed the strongest effect in EA×depression with percentage spent in SWS (%SWS), where %SWS increased with EA in non-depressed subjects. We observed increased thicknesses in three cortical regions in emotionally-abused, non-depressed individuals from structural MRI. Mediation analysis demonstrated that %SWS significantly mediated the association of EA×depression with cortical thickness in two of the three regions.</div></div><div><h3>Limitations</h3><div>We are not able to infer any causal role of sleep in our cross-sectional design. Self-report questionnaires are also subject to recall-bias.</div></div><div><h3>Conclusions</h3><div>Higher regional cortical thicknesses in emotionally-abused, non-depressed individuals can partially be explained by increased %SWS, suggesting a potentially protective role of SWS against brain volume loss associated with EA and depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 92-103"},"PeriodicalIF":4.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sport-for-protection program reduces anxiety and depression in youth affected by displacement: A randomized controlled trial of the Game Connect program in Uganda","authors":"Kathleen Latimer ,&nbsp;Rita Larok ,&nbsp;John Paul Nyeko ,&nbsp;Lydia Murungi ,&nbsp;Ronald Luwangula ,&nbsp;Bashir Lukungu ,&nbsp;Jeroen Carrin ,&nbsp;Robinah Nannungi ,&nbsp;Daniel Ojara Comboni ,&nbsp;Esther Nanfuka Kalule ,&nbsp;Simon Rosenbaum ,&nbsp;Davy Vancampfort","doi":"10.1016/j.jad.2025.02.001","DOIUrl":"10.1016/j.jad.2025.02.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Youth affected by displacement are at risk for anxiety and depression. Supervised sport programs are a potentially effective strategy, however trials from displacement contexts are lacking.</div></div><div><h3>Methods</h3><div>Displaced youth and youth from host communities in five humanitarian settings across Uganda aged 15 to 24 years, and with at least mild anxiety and/or depression, were randomized to a 16-week sport-for-protection program or a wait-list control condition. The Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9, adolescent version (PHQ-9-A) were assessed pre- and post-intervention. Linear mixed modelling was conducted.</div></div><div><h3>Results</h3><div>834 young people were randomized (421 in the experimental and 413 in the control condition; median age = 19.0 years; 46.9 % boys; 14.7 % with self-reported or observed disability; 29.5 % from host community and 70.5 % displaced youth). Large effect sizes were found for the anxiolytic (Cohen d = 1.21, 95%CI = 1.06–1.36) and antidepressant (Cohen d = 1.32, 95%CI = 1.17–1.47) effects of sport-for-protection in comparison with a wait-list control condition. In subgroup analyses, large effect sizes were observed in displaced youth (Cohen d GAD-7 = 1.15, 95%CI = 1.0–1.32; Cohen d PHQ-9-A = 1.33, 95%CI = 1.16–1.51) and youth from host communities (Cohen d GAD-7 = 1.34, 95%CI = 1.06–1.61; Cohen d PHQ-9-A = 1.30, 95%CI = 1.03–1.58); in boys (Cohen d GAD-7 = 1.23, 95%CI = 1.03–1.43; Cohen d PHQ-9-A = 1.36, 95%CI = 1.14–1.58) and girls (Cohen d GAD-7 = 1.11, 95%CI = 0.89–1.33; Cohen d PHQ-9-A = 1.26, 95%CI = 1.05–1.47); and in those with (Cohen d GAD-7 = 0.99, 95%CI = 0.61–1.37.; Cohen d PHQ-9-A = 1.53, 95%CI = 1.12–1.94) and without disability (Cohen d GAD-7 = 1.24, 95%CI = 1.08–1.49; Cohen d PHQ-9-A = 1.28, 95%CI = 1.12–1.44).</div></div><div><h3>Conclusion</h3><div>Sport-for-protection is an effective stand-alone or adjunctive intervention to reduce symptoms of anxiety and depression among young people affected by displacement within humanitarian settings.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 84-91"},"PeriodicalIF":4.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of physical activity, genetic predisposition, and incident depression: An accelerometer-based prospective cohort study","authors":"Ge Tian,&nbsp;Zhi-Ying Yao,&nbsp;Wei Hu,&nbsp;Zhen-Zhen Shen,&nbsp;Bao-Peng Liu,&nbsp;Cun-Xian Jia","doi":"10.1016/j.jad.2025.01.151","DOIUrl":"10.1016/j.jad.2025.01.151","url":null,"abstract":"<div><h3>Background</h3><div>There is a lack of prospective cohort studies exploring the associations between the timing of physical activity and incident depression. This study aimed to explore the associations and to investigate whether genetic predisposition of depression may modify the associations.</div></div><div><h3>Methods</h3><div>The study using data from UK Biobank, included 76,218 participants. The data of total physical activity (TPA) and moderate-to-vigorous physical activity (MVPA) were collected by accelerometer measurements over 7 consecutive days. Cox proportional hazard models were performed to calculate the hazard ratio (HR) and 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>In total, compared to the midday-afternoon group, participants in the early morning group of TPA had a lower risk of depression (HR: 0.76, 95 % CI: 0.65–0.89). Compared to the inactive group, a lower risk of incident depression was found among the participants with MVPA in the morning (HR: 0.80, 95 % CI: 0.67–0.96) and middy-afternoon (HR: 0.82, 95 % CI: 0.70–0.96). The joint effect analysis of the timing of TPA and genetic predisposition for incident depression showed that compared to the participants with a high genetic predisposition and in the middy-afternoon group of TPA, early morning group had a reduced risk of depression regardless of genetic predisposition. However, in subgroup analyses for genetic predisposition, only participants with a high genetic predisposition to depression benefited from TPA in the early morning.</div></div><div><h3>Conclusions</h3><div>TPA in the early morning and MVPA in the morning and middy-afternoon were significantly associated with a lower depression risk, especially for participants with a higher genetic predisposition of depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 131-138"},"PeriodicalIF":4.9,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of effectiveness and side effects of selegiline transdermal system versus oral monoamine oxidase inhibitors and tricyclic antidepressants for treatment-resistant depression","authors":"Thomas T. Kim ,&nbsp;Colin Xu ,&nbsp;Jay D. Amsterdam","doi":"10.1016/j.jad.2025.02.003","DOIUrl":"10.1016/j.jad.2025.02.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Several studies suggest that oral monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) may be more effective than serotonin reuptake inhibitors for treating treatment-resistant depression (TRD). Despite this advantage, they are now rarely prescribed due to concern over serious side effects. In contrast, selegiline transdermal system (STS) may present a safer alternative to oral MAOIs and TCAs; however, no studies have compared STS with other antidepressants.</div></div><div><h3>Methods</h3><div>Data from 117 patients who received STS, oral MAOIs, or TCAs for TRD were obtained from a university mood disorder clinic. Two linear regression models were created with severity and number of side effect categories endorsed as the dependent variable. Logistic regression models were created for each side effect category with presence of category as the dependent variable. In all models, antidepressant class was entered as the independent variable, with covariates.</div></div><div><h3>Results</h3><div>Although STS was less effective than oral MAOIs, it was significantly more effective than TCAs. STS treatment had significantly fewer side effect categories endorsed versus oral MAOIs and TCAs. Patients receiving STS were less likely to report gastrointestinal side effects versus TCAs and to endorse cardiovascular side effects versus oral MAOIs. In contrast, STS patients were more likely to report skin side effects versus oral MAOIs. There were no reported serious adverse events. Amongst the covariates, only the number of prior antidepressant trials predicted more side effect categories endorsed.</div></div><div><h3>Conclusions</h3><div>Although oral MAOI therapy has been eschewed by most clinicians, STS may be better tolerated than oral MAOIs and TCAs.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 47-51"},"PeriodicalIF":4.9,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143132760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom modulation and tolerability of intravenous ketamine in treatment-resistant bipolar depression: A retrospective study","authors":"Alessandro Cuomo ,&nbsp;Simone Pardossi ,&nbsp;Giovanni Barillà ,&nbsp;Pietro Carmellini ,&nbsp;Bernardo Firenzuoli ,&nbsp;Francesca Tarantino ,&nbsp;Rebecca Tinturini ,&nbsp;Andrea Fagiolini","doi":"10.1016/j.jad.2025.01.059","DOIUrl":"10.1016/j.jad.2025.01.059","url":null,"abstract":"<div><div>Ketamine's use in treating bipolar depression must account for risks, such as switching to manic episodes or worsening symptoms. This study examines ketamine's impact on depressive symptoms, focusing on ‘inner tension,’ ‘sleep reduction,’ and ‘suicidal ideation’ over four weeks in treatment-resistant bipolar disorder (TR-BD) patients. Fifty-nine patients with TR-BD were treated consecutively with ketamine (avg dose 0.8 mg/kg). Results showed significant reductions in MADRS scores without manic switches. Ketamine was well-tolerated despite polypharmacy.</div><div>Antidepressant treatment of bipolar depression requires great caution because of the risk of switching to manic-mixed episodes and worsening of symptoms such as internal tension, psychomotor agitation, and suicide risk. The aim of this study was to evaluate the efficiency and tolerability of intravenous ketamine in patients with bipolar I or bipolar II disorder and a current treatment-resistant depressive episode (TR-BD), with the aim of examining: 1) the risk of manic switches; 2) the effect on global depressive symptoms as measured by the Montgomery-Åsberg Depression Rating Scale (MADRS); and 3) the specific effects on the MADRS items of internal tension, sleep disturbance, and suicidal ideation over a four-week period. Fiftynine patients with TR-BD (51.4 ± 12.3 years; 30 % female) treated consecutively with intravenous ketamine (mean dose 0.8 mg/kg) were included in this study. No ketamine-treated patient experienced a manic switch during the observation period. A statistically significant decrease (i.e., improvement) in MADRS global score and scores on the Internal Tension, Reduced Sleep, and Suicidal Ideation items was observed from the second week, with no evidence of worsening of the above symptoms. Patient-reported adverse events were generally mild to moderate.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 76-83"},"PeriodicalIF":4.9,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143132757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between sleep duration and cognitive function in the U.S. elderly from NHANES 2011–2014: A mediation analysis for inflammatory biomarkers","authors":"Meichang Wang ,&nbsp;Xiaoli Zeng ,&nbsp;Qifen Liu ,&nbsp;Zilin Yang ,&nbsp;Jingzhi Li","doi":"10.1016/j.jad.2025.01.154","DOIUrl":"10.1016/j.jad.2025.01.154","url":null,"abstract":"<div><h3>Background</h3><div>Studies have shown a close association between sleep duration and cognitive function in older adults. However, no studies have explored the underlying mechanisms of this relationship. This study was designed to assess the role of inflammatory markers in the relationship between sleep duration and cognitive function in older Americans.</div></div><div><h3>Methods</h3><div>A total of 2502 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analysis. Cognitive function was assessed using three tests from NHANES. Sleep duration was evaluated through a self-reported sleep time questionnaire. Inflammatory biomarkers examined included leukocytes (WBC) count, neutrophil count (NE), the neutrophil-to-lymphocyte ratio (NLR), and the systemic immune-inflammation index (SII). Mediation models were constructed to clarify the mediating role of inflammatory biomarkers.</div></div><div><h3>Results</h3><div>Long sleep duration (≥9 h) was associated with lower performance on CERAD (OR: -1.623; 95 % CI: −2.979 to −0.267) and DSST (OR: -3.084; 95 % CI: −5.861 to −0.308) compared to the normal sleep duration group (7–9 h). NE partially and indirectly mediated this association. Meanwhile, WBC moderated the association between long sleep duration (≥9 h) and DSST performance.</div></div><div><h3>Limitations</h3><div>The cross-sectional design prevents making causal inferences.</div></div><div><h3>Conclusions</h3><div>Long sleep duration is a risk factor for cognitive function. Inflammatory biomarkers based on blood cells present a readily accessible and cost-effective strategy for identifying sleep disorders and also significantly mediate the association between long sleep duration and cognitive function.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 465-471"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social isolation and depressive symptoms among older adults with different functional status in China: A latent class analysis","authors":"Xuan Liu ,&nbsp;Jun-Han Chen ,&nbsp;Bo Gao ,&nbsp;Wan-Jia Zhang","doi":"10.1016/j.jad.2025.01.156","DOIUrl":"10.1016/j.jad.2025.01.156","url":null,"abstract":"<div><h3>Background</h3><div>Social isolation is considered a risk factor for depression in older adults. Since there may be heterogeneity in the experience of social isolation, we aimed to investigate social isolation patterns and their association with depressive symptoms, for older adults with different functional status separately.</div></div><div><h3>Methods</h3><div>This study used data from the fifth wave of the China Health and Retirement Longitudinal Study (CHARLS). A total of 8262 participants, defined as older adults aged 60 years and above, were included in the analysis, comprising 49.9 % (<em>n</em> = 4124) men and 50.1 % (<em>n</em> = 4138) women. Latent class analysis was conducted to identify social isolation patterns. Binary logistic regression was used to estimate the association between latent classes and depressive symptoms.</div></div><div><h3>Results</h3><div>Two distinct classes were identified in participants with functional dependency and three classes were identified in participants without functional dependency. The severely isolated with minimal family and social contact group was associated with a higher risk of depressive symptoms in both subgroups (participants with functional dependency: OR = 1.319, 95%CI: 1.032–1.686; participants without functional dependency: OR = 1.537, 95%CI: 1.209–1.953). No difference was found in the risk of depressive symptoms between the moderately isolated with family contact group and the low isolated group among participants without functional dependency (OR = 1.020, 95%CI: 0.83–1.252).</div></div><div><h3>Conclusion</h3><div>Risk of depressive symptoms varies with different social isolation patterns among older people with different functional status.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 478-485"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal resting-state functional connectivity in panic disorder: An exploratory whole-brain MRI study","authors":"Ryo Sasaki ,&nbsp;Tsuyoshi Eiro ,&nbsp;Masao Takaishi ,&nbsp;Ryota Nakamura ,&nbsp;Haruhisa Yoshida ,&nbsp;Asuka Yoshimi ,&nbsp;Takeshi Asami","doi":"10.1016/j.jad.2025.01.157","DOIUrl":"10.1016/j.jad.2025.01.157","url":null,"abstract":"<div><h3>Background</h3><div>Panic disorder (PD) is characterized by prolonged anxiety about panic attacks, significantly impairing social functioning. Despite this impact, resting-state brain function anomalies in PD are insufficiently understood. We conducted a data-driven investigation of resting-state functional connectivity (rsFC) in PD.</div></div><div><h3>Methods</h3><div>MRI scans and clinical assessments were performed on PD patients and healthy controls (HCs). Differences in rsFC were analyzed using the cluster-wise analysis of 9045 connections among 135 regions across the brain. For significant clusters, correlations between rsFC and clinical scores for panic and anxiety symptoms were examined.</div></div><div><h3>Results</h3><div>Thirty-nine patients and 44 HCs were included in the analyses. A significant cluster-level difference in rsFC was observed between groups, involving connections between the medial occipital region and the paracingulate gyrus within the anterior cingulate cortex (ACC). In this cluster, PD patients exhibited higher rsFC in 11 connections, with eight of these showing positive correlations with State-Trait Anxiety Inventory scores.</div></div><div><h3>Limitations</h3><div>The comprehensive analysis of 9045 connections may have diluted statistical power, potentially obscuring other relevant connections.</div></div><div><h3>Conclusions</h3><div>Increased rsFC between the medial occipital region and the ACC was observed in PD. This suggests that anxiety-evoking visual imagery generated in the occipital lobe may disproportionately influence self-referential thought process mediated by the ACC. Interventions targeting visual imagery may help alleviate daily anxiety in PD patients.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 18-25"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal associations between late-life depression, cerebrovascular disease and cognition","authors":"Mansimran S. Loyal ,&nbsp;Katya Numbers ,&nbsp;Simone Reppermund ,&nbsp;Henry Brodaty ,&nbsp;Perminder S. Sachdev ,&nbsp;Louise Mewton ,&nbsp;Jiyang Jiang ,&nbsp;Ben C.P. Lam","doi":"10.1016/j.jad.2025.01.147","DOIUrl":"10.1016/j.jad.2025.01.147","url":null,"abstract":"<div><h3>Background</h3><div>Depression and vascular disease can both be risk factors for cognitive decline. This study assessed whether indicators of vascular disease are associated with depression over time, and whether depression is associated with cognition independent of vascular disease.</div></div><div><h3>Methods</h3><div>Participants were 1032 community-dwelling, older adults from the Sydney Memory and Ageing Study. Depressive symptoms were measured on the 15-item Geriatric Depression Scale, and depression trajectories were classified using latent class growth modelling. Global cognition and individual cognitive domains were assessed. Indicators of vascular disease were history of stroke or transient ischaemic attack (TIA) and total white matter hyperintensities (TWMH). Generalised linear mixed modelling assessed whether vascular markers were associated with change in depressive symptoms over time. Linear mixed modelling examined relationships between depression, vascular disease indicators, and cognition.</div></div><div><h3>Results</h3><div>History of stroke/TIA or TWMH did not predict depression over time (<em>p</em> = 0.11 and <em>p</em> = 0.70). Baseline stroke/TIA history was associated with a decline in attention over time (b = −0.05, <em>p</em> = 0.04). Significant differences between latent depression trajectories classes in cognitive decline were observed, with participants who became depressed over time experiencing decline in global cognition (b = −0.04, <em>p</em> &lt; 0.001), attention (b = −0.05, p &lt; 0.001) and executive function (b = −0.05, p &lt; 0.001), compared to the non-depressed group.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that depression in later life may not precede cognitive decline. Instead, depressive symptoms and cognitive decline, particularly in attention and executive function, may evolve in tandem over time. This reinforces the importance of early identification and treatment of depression in older adults to potentially mitigate cognitive deterioration.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 59-67"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral protein inflammatory biomarkers in bipolar disorder and major depressive disorder: A systematic review and meta-analysis","authors":"Ridhi Gopalakrishnan ,&nbsp;Yifan Wang ,&nbsp;Flavio Kapczinski ,&nbsp;Benicio N. Frey ,&nbsp;Bianca Wollenhaupt-Aguiar","doi":"10.1016/j.jad.2025.01.150","DOIUrl":"10.1016/j.jad.2025.01.150","url":null,"abstract":"<div><h3>Objectives</h3><div>Bipolar disorder (BD) and major depressive disorder (MDD) are mood disorders. The most frequent clinical presentation of BD and MDD is depression, which contributes to high rates of misdiagnosis between disorders. To support diagnostic discrimination and therapeutic stratification, we aim to perform a systematic review and meta-analysis evaluating peripheral protein inflammatory biomarkers between BD and MDD, with a focus on the depressive state.</div></div><div><h3>Methods</h3><div>We conducted a literature search on PubMed, PsycInfo and Embase with no year/language restrictions. Original studies including human participants with a BD or MDD diagnosis which directly compared levels of peripheral protein inflammatory biomarkers between groups were included. A random effects meta-analysis was performed.</div></div><div><h3>Results</h3><div>35 studies were included in the systematic review. 9 studies were included in the meta-analysis. The meta-analysis showed IL-7 (<em>p</em> &lt; 0.01) levels were significantly decreased in BD, and IL-9 (p &lt; 0.01), CCL3 (<em>p</em> = 0.03), CCL4 (<em>p</em> = 0.01), CCL5 (<em>p</em> = 0.02) and CCL11 (<em>p</em> = 0.04) levels were significantly increased in BD.</div></div><div><h3>Limitations</h3><div>High heterogeneity and limited dataset size restricted our meta-analysis to a small subset of biomarkers and limited our exploration of the effects of moderator variables.</div></div><div><h3>Conclusion</h3><div>This study found differences in IL-7, IL-9, CCL3, CCL4, CCL5 and CCL11 between BD and MDD in a depressive state. These findings support the notion that inflammation is associated with mood disorder pathophysiology, particularly with respect to T-cell network dysregulation. Further studies can assist in better understanding differences between disorders and work towards clinical applications.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"376 ","pages":"Pages 149-168"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}