Journal of affective disorders最新文献

{"title":"Questionable prospective decreasing effect of internet use on depression: A simulated reanalysis and comment on Liu et al. (2024).","authors":"Kimmo Sorjonen, Bo Melin","doi":"10.1016/j.jad.2025.120053","DOIUrl":"10.1016/j.jad.2025.120053","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120053"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution and psychiatric outcomes - is Mendelian randomisation an appropriate analysis?","authors":"Gavin P Reynolds","doi":"10.1016/j.jad.2025.120061","DOIUrl":"10.1016/j.jad.2025.120061","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120061"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, correlates, functional impairment and mental health service gap of anxiety disorders among elderly population in China.","authors":"Jianan Song, Xiaofei Hou, Tingting Zhang, Yueqin Huang, Xiangdong Wang, Xiufeng Xu, Zhizhong Wang, Yifeng Xu, Tao Li, Minghui Li, Xiangdong Xu, Limin Wang, Yongping Yan, Shuiyuan Xiao, Lingjiang Li, Jie Yan, Yaqin Yu, Zhaorui Liu, Huifang Yin, Guangming Xu","doi":"10.1016/j.jad.2025.120007","DOIUrl":"10.1016/j.jad.2025.120007","url":null,"abstract":"<p><strong>Aims: </strong>To report the prevalence and correlates of anxiety disorders among the elderly population in China; and to describe functional impairment and mental health service utilization due to anxiety disorders.</p><p><strong>Methods: </strong>Data were derived from the Chinese Mental Health Survey. Weighted prevalence rates of various anxiety disorders were calculated. Logistic regression analyses were conducted to investigate correlates associated with anxiety disorders. Functional impairment and mental health service utilization were also assessed.</p><p><strong>Results: </strong>The weighted lifetime prevalence and 12-month prevalence of any anxiety disorder were 9.2 % and 6.0 %, respectively. Older adults with more chronic physical conditions, comorbid depressive disorders, and substance use disorders were more likely to have anxiety disorders. A substantial proportion of older adults reported functional impairment across different domains. Among respondents with 12-month anxiety disorders, only 11.8 % had sought any mental health services in the past year.</p><p><strong>Conclusions: </strong>Anxiety disorders are highly prevalent and cause serious impairment in the Chinese elderly population. Some correlates should be considered in the prevention and management of anxiety disorders. Additionally, the notable gap in mental health service utilization for anxiety disorders among the elderly in China highlights the need for improved healthcare services.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120007"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"U-shaped association between daily eating frequency and nighttime fasting duration and depression in NHANES 2005-2018.","authors":"Yan Chen, Ruilan Gong, Qianzhu Li, Yina Wang, Lijun Wang, Xuanyang Wang","doi":"10.1016/j.jad.2025.120010","DOIUrl":"10.1016/j.jad.2025.120010","url":null,"abstract":"<p><strong>Background: </strong>Existing studies display certain limitations and inconsistencies regarding the association between daily eating frequency (DEF) and nighttime fasting duration (NFD) and depression. We examines the relationships between DEF, NFD, and depression.</p><p><strong>Methods: </strong>Among the 29,035 subjects in the National Health and Nutrition Examination Survey (NHANES) 2005-2018, depression is defined by a total Patient Health Questionnaire-9 (PHQ-9) score of at least 10. DEF is quantified through the number of eating instances, and NFD is evaluated by examining the day's first and last meals. Weighted logistic regression models, restricted cubic spline (RCS), and mediation analysis are performed.</p><p><strong>Results: </strong>In comparison to DEF between 3.6 and 4.0 times, subjects with DEF ≤ 3 times (OR 1.28, 95 % CI 1.11-1.49) and DEF ≥ 4.6 times (OR 1.17, 95 % CI 1.01-1.34) have a greater risk of depression. Relative to NFD ranging from 12.1 to 13.3 h, those with NFD ≤ 10.8 h (OR 1.32, 95 % CI 1.14-1.52) and NFD ≥ 14.9 h (OR 1.37, 95 % CI 1.19-1.59) are at increased risk of depression. The U-shaped smoothing curves for the association further validate the findings. Blood urea nitrogen (BUN) and globulin (Glo) play a mediating role in the association. Among subjects having a lower daily energy intake, the impact of DEF and NFD on depression is more significant (P_interaction < 0.05).</p><p><strong>Conclusions: </strong>DEF ≤ 3 or ≥ 4.6 times and NFD ≤ 10.8 or ≥ 14.9 h are independently related to increased depression risk.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120010"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal-prefrontal functional magnetic resonance imaging signature of suicidal ideation in major depressive disorder.","authors":"Xiao-Yuan An, Zhi-Peng Guo, Li-Rong Tang, Yue Gao, Na Wang, Ping Li, Chun-Hong Liu","doi":"10.1016/j.jad.2025.120019","DOIUrl":"10.1016/j.jad.2025.120019","url":null,"abstract":"<p><strong>Background: </strong>Although suicidal ideation (SI) represents a critical manifestation associated with major depressive disorder (MDD), existing diagnostic methods remain largely subjective. This study adopted resting-state functional magnetic resonance imaging techniques to examine objective neural biomarkers connected to SI in patients with MDD.</p><p><strong>Methods: </strong>Participants comprised 50 patients with MDD and SI (MDD-SI), 56 patients with MDD without SI, and 55 healthy control individuals (HCs), matched by demographic variables. Regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF) analyses were conducted to characterize brain activity patterns. The detected neural features underwent independent clinical correlation and support vector machine (SVM) analyses to evaluate their clinical and diagnostic relevance.</p><p><strong>Results: </strong>In MDD-SI subjects, elevated fALFF was observed in the middle frontal and right postcentral gyri, with a marginal increase in the left hippocampus. They exhibited unique hyperactivation in the right orbitofrontal cortex (OFC) as measured by ReHo, distinguishing them from patients with HCs and MDD without SI. Among individuals in the SI group, left hippocampal fALFF exhibited a significant negative association with depression severity scores (p < 0.05). The SVM classifier reached 63.81 % accuracy in distinguishing MDD-SI individuals from HCs based on ReHo in the right lateral OFC.</p><p><strong>Conclusion: </strong>The study provides novel evidence for distinct neural substrates underlying SI in MDD, highlighting the involvement of hippocampal-prefrontal circuits and sensory integration regions. Despite limitations related to cross-sectional design and medication effects, the findings enhance the understanding of suicide-related brain changes and may aid in identifying biological markers of suicide risk.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120019"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel drug targets for mental disorders through genetic, colocalization, and network pharmacology approaches.","authors":"Ying Xiong, Xing Yang, Jie Jie","doi":"10.1016/j.jad.2025.120047","DOIUrl":"10.1016/j.jad.2025.120047","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia, bipolar disorder, and PTSD are prevalent psychiatric conditions with overlapping genetic and environmental risk factors. Current treatments often fall short due to issues like treatment resistance, side effects, and variable patient adherence. This study investigates shared molecular mechanisms and actionable therapeutic targets across these disorders.</p><p><strong>Methods: </strong>We integrated genetic data from over 500,000 individuals in the Psychiatric Genomics Consortium and FinnGen biobank. A multi-step framework combined protein quantitative trait loci analysis, Mendelian randomization for causal inference, cross-disorder meta-analyses, and colocalization to prioritize protein targets.</p><p><strong>Results: </strong>Genetic correlations confirmed pleiotropic links among the three disorders. Cross-disorder analyses identified ITIH1 and TIMP4 as consistently associated proteins. Colocalization revealed four high-confidence targets: IGLON5 (synaptic plasticity, OR = 0.69), PTK7 (apoptosis regulation, OR = 0.71), LIMA1 (lipid metabolism, OR = 0.52), and HBEGF (neurotrophic signaling, OR = 1.21). These proteins converge on glycosphingolipid biosynthesis and stress-response pathways. Molecular docking confirmed druggable potential, with binding energies below -7.0 kcal/mol.</p><p><strong>Conclusions: </strong>IGLON5, PTK7, LIMA1, and HBEGF emerge as mechanistically grounded targets for transdiagnostic therapies. HBEGF's bidirectional effects highlight its potential for personalized treatment strategies. Our integrative approach-combining causal inference, multi-omics data, and computational validation-provides a scalable framework for neuropsychiatric drug discovery.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120047"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Motor dysfunction in late life depression: A mood or movement disorder?\" [J. Affect. Disord. volume 381 (2025) 680-691/ISSN 0165-0327].","authors":"Margot G A Van Cauwenberge, Thomas Vande Casteele, Maarten Laroy, Kristof Vansteelandt, Jan Van den Stock, Filip Bouckaert, Louise Emsell, Mathieu Vandenbulcke","doi":"10.1016/j.jad.2025.120043","DOIUrl":"10.1016/j.jad.2025.120043","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120043"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Causal mediation analysis of the role of platelet count in the association between depression and mortality in US adults\" [J. Affect. Disord. 389 (2025), Article 119689].","authors":"Zhiyi Wang, Xiaojing Teng","doi":"10.1016/j.jad.2025.120042","DOIUrl":"10.1016/j.jad.2025.120042","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120042"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between long-term exposure to low ambient benzene concentrations and mental disorders in the UK: A nested case-control study.","authors":"Yu Wu, Binbin Su, Yihao Zhao, Chen Chen, Yaohua Tian, Xiaoying Zheng","doi":"10.1016/j.jad.2025.120025","DOIUrl":"10.1016/j.jad.2025.120025","url":null,"abstract":"<p><strong>Background: </strong>The mental health impacts of long-term ambient benzene exposure remain incompletely understood. We aim to investigate the association between long-term exposure to low-concentration ambient benzene and mental disorders in the general population.</p><p><strong>Method: </strong>Estimated annual benzene concentrations from UK-wide air pollution maps were linked to health data from 410,605 eligible UK Biobank participants. A nested case-control analysis was performed to assess the risk of all-cause and ten specific mental disorders, using 1:4 risk-set matching with replacement (matching each case to up to four controls). Conditional logistic regression estimated odds ratios (ORs) and 95 % confidence intervals (CIs), and restricted cubic spline models evaluated exposure-response relationships. Subgroup analyses identified potential vulnerable populations.</p><p><strong>Results: </strong>In fully adjusted models, per interquartile range (IQR) increase in benzene exposure was associated with higher risks of all-cause mental disorders (OR: 1.19, 95 % CI: 1.16-1.23), mood disorders (OR: 1.12, 95 % CI: 1.06-1.19), anxiety disorders (OR: 1.31, 95 % CI: 1.25-1.38), substance use disorders (OR: 1.23, 95 % CI: 1.16-1.31), and sleep disorders (OR: 1.13, 95 % CI: 1.05-1.23). Significant associations were also observed within six subtypes: depressive episodes, panic disorder, phobic anxiety disorder, post-traumatic stress disorder, alcohol use disorder, and tobacco use disorder. Exposure-response curves were predominantly nonlinear, with risks elevated even at low concentrations, suggesting no clear safe threshold. The associations were generally consistent across subgroups, with stronger risks among individuals without hypertension or diabetes.</p><p><strong>Limitations: </strong>We cannot establish causality.</p><p><strong>Conclusion: </strong>Long-term exposure to low-level ambient benzene concentrations is associated with increased risks of all-cause and specific mental disorders. These findings provide evidence to inform air pollutant management policy.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120025"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepsis increases the risk of dementia in middle-aged and elderly adults: a large prospective cohort study.","authors":"Jie Liu, Yunhan Fei, Enquan Wang, Taipu Guo, Wei Cong, Yan Cui, Keliang Xie","doi":"10.1016/j.jad.2025.120013","DOIUrl":"10.1016/j.jad.2025.120013","url":null,"abstract":"<p><strong>Background & aims: </strong>Sepsis is associated with dementia; however, there is little real-world evidence to study the long-term risk of sepsis for dementia. This study investigated the long-term risk of dementia after sepsis, combined with genetic data, to identify the effects of apolipoprotein E (APOE) on the relationship between sepsis and dementia and provide data support for the later management of sepsis.</p><p><strong>Methods: </strong>This large-scale, prospective cohort study evaluated participants from the UK Biological Sample Bank. A multivariate Cox proportional hazards model was used to examine the relationship between sepsis and the risk of long-term dementia. A stratified analysis was conducted to elucidate the relationship between sepsis and dementia in different sex and age groups, as well as in APOE gene populations.</p><p><strong>Results: </strong>Among 499,238 participants, sepsis was associated with higher dementia risk than chronic diseases. Although the risk of dementia after sepsis increased, this association gradually decreases over time with the progressive exclusions of follow-up. Subgroup analysis revealed that sepsis was an independent risk factor for dementia among aged 45 and above. Compared without sepsis patients, sepsis patients carrying APOE ε2 and APOE ε3 alleles had a 2.863 and 2.815 fold increased risk of dementia, respectively (all P < 0.001). However, no significant correlation was found between sepsis and dementia among participants carrying APOE ε4 (P = 0.097).</p><p><strong>Conclusions: </strong>Sepsis increases the short-term dementia risk but not long-term risk. Attention should be paid to people aged 45 and above after sepsis. Notably, The APOE gene affects the sepsis-dementia relationship.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120013"},"PeriodicalIF":4.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}