Journal of affective disorders最新文献

{"title":"Life satisfaction in individuals with premenstrual syndrome: Scale development and evaluation of psychometric properties","authors":"Ahsen Demirhan Kayacik,&nbsp;Kevser Ilcioglu","doi":"10.1016/j.jad.2025.119757","DOIUrl":"10.1016/j.jad.2025.119757","url":null,"abstract":"<div><h3>Background</h3><div>Premenstrual syndrome (PMS) is characterized by various physiological and psychological symptoms occurring in the luteal phase of the menstrual cycle, which may negatively affect women's life satisfaction. Existing general life satisfaction scales are insufficient to assess the impact of PMS-specific multidimensional and cyclical symptoms. This study aimed to develop a valid and reliable life satisfaction scale specific to PMS and to identify the individual and environmental factors that influence this satisfaction.</div></div><div><h3>Methods</h3><div>This methodological and cross-sectional study was conducted in two phases. In the first phase (<em>n</em> = 158), a scale development study was carried out; in the second phase (<em>n</em> = 379), the psychometric properties were evaluated. Exploratory and confirmatory factor analyses were used to assess construct validity, while Cronbach's alpha and McDonald's omega coefficients were calculated for reliability. In the second phase of the study, independent samples <em>t</em>-test, ANOVA, Cohen's d, eta-squared, and multiple linear regression analyses were performed.</div></div><div><h3>Results</h3><div>The 15-item scale with three subdimensions demonstrated acceptable fit indices (RMSEA = 0.078; X2/df = 1.96; CFI = 0.91; GFI = 0.88; AGFI = 0.83) and high reliability (α = 0.880; ꞷ = 0.885). Significant associations were found between life satisfaction scores and factors such as employment status, exercise habits, chronic disease diagnosis, and coping methods for PMS (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The PMS-Specific Life Satisfaction Scale is a valid and reliable tool that comprehensively evaluates the impact of PMS on women's life satisfaction and identifies key influencing factors. The findings suggest that lifestyle factors play an important role and can guide personalized care planning.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119757"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol consumption and mental health in a dynamic longitudinal relationship in a general population sample: A bivariate latent change score model","authors":"Henriette Markwart ,&nbsp;Andreas Staudt ,&nbsp;Jennis Freyer-Adam ,&nbsp;Christian Meyer ,&nbsp;Anne Möhring ,&nbsp;Diana Gürtler ,&nbsp;Hans-Jürgen Rumpf ,&nbsp;Ulrich John ,&nbsp;Sophie Baumann","doi":"10.1016/j.jad.2025.119765","DOIUrl":"10.1016/j.jad.2025.119765","url":null,"abstract":"<div><h3>Objectives</h3><div>The longitudinal relationship of mental health, alcohol consumption, and their direction of effect are not well understood, and findings are mostly heterogeneous. The study investigates the mutual effects of mental health and alcohol consumption over time in a general population sample.</div></div><div><h3>Methods</h3><div>Self-report data of <em>n</em> = 816 adults aged 18–64 who reported any alcohol consumption in the past year (57.5 % female) were used. Participants were proactively recruited at a municipal registry office and provided data at 4 measure points (baseline, 3, 6, and 12 months). Mental health was assessed using the 5-Item Mental Health Inventory. Alcohol consumption was measured as the number of drinks in the last 30 days using a quantity-frequency index. Bivariate latent change score models with different assumptions were estimated in four models: 1) alcohol consumption and mental health trajectories did not influence each other, 2) alcohol consumption influenced changes in mental health, 3) vice versa, and (4) a reciprocal model in which both influenced changes in each other.</div></div><div><h3>Results</h3><div>The third unidirectional coupling model fitted the data best (Chi-square (24) = 107.78, <em>p</em> &lt; .01, CFI = 0.96 RMSEA = 0.06, SRMR = 0.03). Better mental health at earlier assessments was associated with lower alcohol consumption in future, but not vice versa.</div></div><div><h3>Conclusions</h3><div>The results that, among a general population sample of persons who reported any alcohol consumption, higher levels of mental health may spill over and lead to a decrease in monthly alcohol consumption.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119765"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of adult attachment style on bonding mediated by depression and anxiety across the perinatal period","authors":"Muhammad Dwi Wahyu ,&nbsp;Ekachaeryanti Zain ,&nbsp;Yuichiro Watanabe ,&nbsp;Naoki Fukui ,&nbsp;Koyo Hashijiri ,&nbsp;Takaharu Motegi ,&nbsp;Maki Ogawa ,&nbsp;Jun Egawa ,&nbsp;Koji Nishijima ,&nbsp;Toshiyuki Someya","doi":"10.1016/j.jad.2025.119763","DOIUrl":"10.1016/j.jad.2025.119763","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have investigated relationships among adult attachment style, depression, anxiety, and prenatal mother-to-fetus/postnatal mother-to-infant bonding in perinatal women, with varied findings. We examined the direct effects of adult attachment style on bonding as well as indirect effects via depression and anxiety.</div></div><div><h3>Methods</h3><div>In this prospective observational, longitudinal cohort study, 1897 Japanese perinatal women were recruited from 34 obstetric institutions in Niigata Prefecture. Adult attachment was assessed at T1 (early pregnancy), with depression/anxiety and bonding assessed at T1, T2 (late pregnancy), and T3 (postpartum). We used parallel process latent growth curve modeling to examine direct effects of the T1 adult attachment style on bonding across the perinatal period, as well as the mediating roles of depression and anxiety over three time points.</div></div><div><h3>Results</h3><div>No significant direct effects of adult attachment on bonding trajectories were observed. However, significant indirect effects were found, suggesting that adult attachment style influenced both the initial levels and change in bonding via its impact on the developmental trajectories of both depression and anxiety, with distinct roles for each mediator. The model fit was good to acceptable.</div></div><div><h3>Limitations</h3><div>This study was limited by reliance on self-report measures, geographically restricted samples, and the absence of long-term follow-up.</div></div><div><h3>Conclusion</h3><div>We found that the impact of adult attachment style on bonding was mediated by depression and anxiety across the perinatal period. Early screening and intervention for depressive and anxiety symptoms related to the mother's attachment toward her romantic partner is essential to prevent bonding difficulties.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119763"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression intervention using AI chatbots with social cues: a randomized trial of effectiveness","authors":"Shuo Xu ,&nbsp;Tiancong Ma","doi":"10.1016/j.jad.2025.119760","DOIUrl":"10.1016/j.jad.2025.119760","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a serious problem among college students, and chatbots are a popular intervention tool. Social cues are used in chatbot design, but their effectiveness in depression treatment remains to be verified. This study aimed to compare the effects of chatbots with high-social-cue (HSC) versus low-social-cue (LSC) designs on depressive symptoms.</div></div><div><h3>Methods</h3><div>An open-label randomized controlled trial was conducted over 16 weeks. Eighty-four college students with baseline Patient Health Questionnaire-9 (PHQ-9) scores ≥9 were randomly assigned to either an HSC group (text + voice + animations) or LSC group (text-only). Clinical outcomes, including PHQ-9, Generalized Anxiety Disorder scale (GAD-7), and Positive and Negative Affect Schedule (PANAS) scores, were collected every 4 weeks. Secondary measures included user satisfaction (Client Satisfaction Questionnaire-8, CSQ-8), therapeutic alliance (Working Alliance Inventory-Short Revised, WAI-SR), and self-reported adherence.</div></div><div><h3>Results</h3><div>Baseline characteristics did not differ significantly between groups. Intention-to-treat analysis revealed that the HSC group achieved greater reductions in PHQ-9 (d = 0.63, <em>P</em> &lt; 0.01) and GAD-7 (d = 0.50, <em>P</em> = 0.003) scores compared to the LSC group. The HSC group also demonstrated higher adherence rates (d = 0.82, <em>P</em> &lt; 0.01), CSQ-8 (<em>P</em> = 0.02), and WAI-SR scores (<em>P</em> &lt; 0.001). LSC group.</div></div><div><h3>Conclusion</h3><div>Chatbots with high-social-cue designs significantly outperformed text-only versions in alleviating depression and anxiety, while enhancing adherence, satisfaction, and therapeutic alliance.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119760"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Neutrophil to albumin ratio as a novel associated factor for depression; results from NHANES 2017–2018” [J. Affect. Disord., 379 (2025) 72–78]","authors":"Amirhomayoun Atefi ,&nbsp;Aref Ghanaatpisheh ,&nbsp;Mohammad Fereidouni ,&nbsp;Ghazaleh Habibi ,&nbsp;Fateme Takrimi Niarad ,&nbsp;Ehsan Aboutaleb","doi":"10.1016/j.jad.2025.119553","DOIUrl":"10.1016/j.jad.2025.119553","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119553"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of intergenerational associations: Parental childhood trauma, depression, anxiety, and adolescent maladaptive traits in depressed youth","authors":"Nan Guo ,&nbsp;Aiqun Yang ,&nbsp;Ye Xu ,&nbsp;Qi Liu ,&nbsp;Chuanshi Su ,&nbsp;Daxing Wu","doi":"10.1016/j.jad.2025.119761","DOIUrl":"10.1016/j.jad.2025.119761","url":null,"abstract":"<div><h3>Background</h3><div>Adolescent depression, comorbid with maladaptive traits, increases the risks of suicide and psychosocial dysfunction, yet intergenerational pathways linking parental childhood trauma, depression, anxiety, and adolescent maladaptive traits remain complex and unclear. This study aimed to use network analysis to investigate these transmission mechanisms in clinically depressed adolescents.</div></div><div><h3>Methods</h3><div>This study recruited 138 parent-adolescent pairs (M_<em>age</em> = 15.92, <em>SD</em> = 1.84 for adolescents; M_<em>age</em> = 43.65, <em>SD</em> = 5.37 for parents) to complete the assessment. Network analysis was applied to explore the associations between parental trauma, psychopathology, and adolescent maladaptive traits.</div></div><div><h3>Results</h3><div>The results showed that: (1) parental childhood trauma subtypes were linked to adolescent maladaptive traits through parental depression/anxiety; (2) physical abuse and emotional neglect exhibited the highest strength centrality among parental traumas, while impulsive-need for stimulation was the most central maladaptive trait in adolescents; (3) parental depression and anxiety emerged as bridge symptoms, connecting the transmission from parental trauma to adolescent maladaptation.</div></div><div><h3>Limitations</h3><div>Cross-sectional design limits causal inferences.</div></div><div><h3>Conclusions</h3><div>These results indicated that parental psychopathology mediated intergenerational transmission, with parental physical abuse, emotional neglect and adolescent impulsivity serving as network hubs. By identifying bridge symptoms and central traits, this study provides actionable targets for breaking intergenerational dysfunction, emphasizing that clinical interventions targeting parental depression/anxiety may more effectively disrupt transmission cycles than adolescent-focused therapies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119761"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy planning and partner support: Protective factors for women's perinatal wellbeing in Sweden?","authors":"Hanna Wierenga ,&nbsp;Alkistis Skalkidou ,&nbsp;Pia Schober","doi":"10.1016/j.jad.2025.119723","DOIUrl":"10.1016/j.jad.2025.119723","url":null,"abstract":"<div><h3>Background</h3><div>Partner support and pregnancy planning are recognized as supportive factors for perinatal wellbeing. Following the biopsychosocial model of health, this study investigates how the planning of a pregnancy and partner support relates to depressive symptoms in late pregnancy.</div></div><div><h3>Methods</h3><div>Using data from the Swedish Mom2B mHealth app (<em>n</em> = 3696), we applied structural equation modelling to assess the pathways from pregnancy planning and partner support, in early pregnancy to depressive symptoms in late pregnancy. We modelled the planning of parental leave division, physical symptoms, and stress as mediators. As an additional sensitivity analysis, we ran a model interacting the predictors with the employment status.</div></div><div><h3>Results</h3><div>Partner support had no significant direct effect on depressive symptoms, but it showed significant indirect effects via stress (β = −0.10) and leave sharing (β = −0.004). Pregnancy planning had stronger indirect effects via stress (β = −0.8) than parental leave sharing (β = −0.002). Pregnancy planning and partner support were also associated to each other (β = 0.18) and, more planned pregnancies were linked with the partner taking a shorter parental leave. The strongest pathways linked physical pregnancy symptoms and stress to depressive symptoms. Interaction models showed that those with an insecure employment status experienced more stress and depression, but that the disparities between the groups were alleviated, when women perceived greater support from their partner.</div></div><div><h3>Conclusion</h3><div>Partner support and pregnancy planning impact maternal mental health through indirect psychosocial and physical pathways, emphasizing the value of addressing stress and physical pregnancy symptoms in antenatal care.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119723"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between local public health unit funding and adolescent mental health during the COVID-19 pandemic: Longitudinal findings from the Ontario public health information database (OPHID) and COMPASS studies.","authors":"Stephen Hunter, Brendan T Smith, Naomi Schwartz, Steven Rebellato, Karen A Patte, Carla Hilario, Laura Andersen, Scott T Leatherdale, Roman Pabayo","doi":"10.1016/j.jad.2025.119759","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119759","url":null,"abstract":"<p><strong>Background: </strong>Public health units (PHU) require adequate funding to service the needs of their community. This study examined the association between PHU funding and adolescent mental health trajectories from 2018 to 19 to 2020-21 in Ontario, Canada.</p><p><strong>Methods: </strong>Longitudinal adolescent data from the Cannabis, Obesity, Mental health, Physical activity, Alcohol, Smoking, and Sedentary behaviour (COMPASS) study (n = 6043) was used. Adolescents reported on depression and anxiety symptoms via questionnaire. Data on funding from 12 PHUs was obtained from the Ontario Public Health Information Database. We used multilevel growth curve analyses to estimate whether PHU funding modified trajectories of depressive and anxiety symptoms while adjusting for student, school, and area-level covariates. We also tested for heterogeneity by gender and performed gender stratified analyses.</p><p><strong>Results: </strong>PHU funding modified depression trajectories. Differences in depression scores by level of PHU funding were not significant at each time point. However, students attending schools in areas with lower PHU funding had smaller rates of growth in depression from 2018 to 19 to 2019-20 (Low PHU: ∂ = 0.50, 95 % CI: 0.27, 0.74; High PHU: ∂ = 1.10, 95 % CI: 0.81, 1.39), but larger rates of growth from 2019 to 20 to 2020-21 (Low PHU: ∂ = 1.66, 95 % CI: 1.32, 2.00; High PHU: ∂ = 0.70, 95 % CI: 0.35, 1.05). Findings were similar in female stratified models. PHU funding did not modify anxiety trajectories.</p><p><strong>Conclusion: </strong>Trajectories of adolescent depression symptoms, particularly females, during the COVID-19 pandemic may have been modified by the level of PHU funding. More research over a longer period and in different jurisdictions is needed.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119759"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic Regulation of Ferroptosis by the KDM3A/BRPF1 Transcriptional Axis Confers Neuroprotection in Postpartum Depression mouse model","authors":"Jiangli Lan ,&nbsp;Yanqiong Zhou ,&nbsp;Lingyan Deng ,&nbsp;Huan Liu ,&nbsp;Wei Hong ,&nbsp;Ren Jing ,&nbsp;Jianqiu Zheng","doi":"10.1016/j.jad.2025.119690","DOIUrl":"10.1016/j.jad.2025.119690","url":null,"abstract":"<div><h3>Background</h3><div>Postpartum depression (PPD) represents a debilitating perinatal psychiatric disorder with elusive pathogenesis. While ferroptosis—an iron-dependent regulated cell death pathway—is implicated in neuropsychiatric conditions, its mechanistic role in PPD remains undefined.</div></div><div><h3>Methods</h3><div>We integrated blood-derived protein quantitative trait loci (bd-pQTL) from 35,559 Icelanders with FerrDb-curated ferroptosis genes through bidirectional Mendelian randomization (MR) to identify causal PPD regulators. Mediation MR delineated ferroptosis-related pathways validated in an ovariectomy/hormone-withdrawal mouse model simulating postpartum neuroendocrinology. Multimodal assessment combined behavioral phenotyping, ferroptotic biomarker quantification, transcriptional profiling, and pharmacological ferroptosis inhibition (Ferrostatin-1).</div></div><div><h3>Results</h3><div>Primary MR identified 159 ferroptosis-related genes, with BRPF1 exerting robust protection against PPD (IVW <em>OR</em> = 0.797, <em>P</em> = 0.009). Chromatin modifier KDM3A governed BRPF1 expression (mediation <em>β</em> = 0.336, <em>P</em> &lt; 0.0001), forming a causal hierarchy that suppressed ferroptosis. Hormone-withdrawn mice recapitulated PPD neuropathology: depression-like behaviors (FST/TST immobility ↑, OFT/LDT exploration ↓, <em>P</em> &lt; 0.0001), ferroptotic signatures (hippocampal Fe²⁺↑, GSH↓, <em>P</em> &lt; 0.001), and KDM3A/BRPF1 axis suppression (GPX4↓, SLC7A11↓, <em>P</em> &lt; 0.001). Ferrostatin-1 administration rescued behavioral deficits, normalized redox homeostasis, and restored KDM3A/BRPF1-mediated GPX4/SLC7A11 transactivation (<em>P</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>We establish an epigenetic paradigm wherein KDM3A orchestrates BRPF1-dependent transcriptional control of ferroptosis defenses (GPX4/SLC7A11), constraining PPD pathogenesis. This KDM3A/BRPF1 axis represents a druggable target, with ferroptosis inhibition demonstrating therapeutic efficacy, informing novel epigenetic-based interventions.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119690"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal consistency, sensitivity, specificity and predictive value of the short version of the Zarit Burden Interview-7 scores: systematic review and generalization meta-analysis","authors":"Júlia Gisbert-Pérez ,&nbsp;Elena Cejalvo ,&nbsp;Manuel Martí-Vilar ,&nbsp;Laura Badenes-Ribera","doi":"10.1016/j.jad.2025.119744","DOIUrl":"10.1016/j.jad.2025.119744","url":null,"abstract":"<div><h3>Objectives</h3><div>The <em>Zarit Burden Interview (</em>ZBI) is one of the most widely used instruments for assessing caregiver burden. One of the most used short scales of the ZBI is the 7-item version. The aim of the study was to conduct a systematic review and generalization meta-analysis of the reliability and validity of the scores of the short version ZBI-7 items to determine whether they provide average values that justify their application and, secondly, to identify the characteristics of the studies that could explain the heterogeneity among the estimates.</div></div><div><h3>Methods</h3><div>Forty-eight articles were identified that applied the short version of the ZBI-7, of which only 14 reported a reliability coefficient and 7 reported sensitivity, specificity and predictive values. A random effects model was applied in the statistical analyses.</div></div><div><h3>Results</h3><div>The average Cronbach's alpha coefficient was 0.866 (95 % CI [0.835, 0.891], k = 15), with high heterogeneity (I² = 86.4 %). Mean sensitivity was 98.6 % (95 % CI [70.0 %–95.3 %], k = 3), mean specificity was 87.4 % (95 % CI [93.6 %–99.7 %], k = 3), mean positive predictive value was 93.7 % (95 % CI [81.3 %–98.1 %], k = 3), mean negative predictive value was 97.3 % (95 % CI [87.5, 99.4], k = 3).</div></div><div><h3>Conclusions</h3><div>According to psychometric theory, the ZBI-7 can be considered reliable and valid for exploratory purposes in both research and clinical practice.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119744"},"PeriodicalIF":4.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}