Journal of affective disorders最新文献

{"title":"Decoding depression: Event related potential dynamics and predictive neural signatures of depression severity","authors":"Bradly T. Stone ,&nbsp;Phillip C. Desrochers ,&nbsp;Masoud Nateghi ,&nbsp;Lina Chitadze ,&nbsp;Yi Yang ,&nbsp;Gabriela I. Cestero ,&nbsp;Zeineb Bouzid ,&nbsp;Chuoqi Chen ,&nbsp;Rachel Bull ,&nbsp;J. Douglas Bremner ,&nbsp;Omer T. Inan ,&nbsp;Reza Sameni ,&nbsp;Spencer K. Lynn ,&nbsp;Bethany K. Bracken","doi":"10.1016/j.jad.2025.119893","DOIUrl":"10.1016/j.jad.2025.119893","url":null,"abstract":"<div><div>Depression is a heterogeneous disorder marked by disruptions in cognitive and affective processing. While self-reported measures and clinical interviews remain the diagnostic standard, integrating objective neurophysiological markers could enhance assessment accuracy. This study demonstrates that event-related potentials (ERPs) derived from electroencephalography (EEG) can accurately classify individuals with major depressive disorder (MDD) and predict depression severity.</div><div>Participants read multi-sentence scenarios designed to vary in predictability and affective valence, with ERPs time-locked to sentence-final critical words. Features from the Late Frontal Positivity (LFP), N400, and Late Posterior Positivity (LPP) were used to train machine learning classifiers for three tasks: clinical diagnosis (MDD vs. Healthy Controls (HCs)), Beck Depression Inventory-II (BDI)-based depression risk, and Patient Health Questionnaire-9 (PHQ9)-based depression risk.</div><div>Our models achieved 80 % accuracy in distinguishing MDD from HC and reliably identified high-risk individuals on both self-reported depression scales. The LPP features were most predictive of clinical diagnosis, whereas N400 and LFP features were more strongly associated with symptom severity. Feature overlap analysis further revealed that distinct neurocognitive processes underlie diagnostic and symptom-based classification, highlighting the potential of these neural markers to capture both categorical and dimensional aspects of depression.</div><div>These findings provide compelling evidence that ERPs can serve as objective biomarkers for depression, moving beyond subjective assessments. By leveraging machine learning to analyze neurophysiological responses to linguistic and affective stimuli, this approach lays the foundation for data-driven, personalized psychiatric evaluation—offering a scalable tool for depression diagnosis and severity stratification.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119893"},"PeriodicalIF":4.9,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of alexithymia in young people and their parents","authors":"Rebecca Naomi Davies ,&nbsp;Kiron Griffin","doi":"10.1016/j.jad.2025.119855","DOIUrl":"10.1016/j.jad.2025.119855","url":null,"abstract":"<div><h3>Aims &amp; hypothesis</h3><div>This systematic review is the first to investigate whether there is a correlation in levels of alexithymia in young people and their parents, with the hypothesis that there is a positive correlation.</div></div><div><h3>Background</h3><div>Alexithymia means “no words for feelings” and encompasses three components: difficulty identifying feelings (DIF<span><span>¹</span></span>), difficulty describing feelings (DDF<span><span>²</span></span>) and externally oriented thinking (EOT<span><span>³</span></span>). Alexithymia is common, affecting 9–17 % of men and 5–10 % of women. Alexithymic adults and children experience higher rates of mental illness. Evidence points to a multifactorial cause including neurobiological, genetic and environmental factors and experienced parenting style. Parental alexithymia has been linked with parental burnout and psychopathology in their children.</div></div><div><h3>Methods</h3><div>A systematic search was undertaken for studies presenting data that directly compared parent-child alexithymic characteristics/measures. Quantitative data were extracted, and a meta-analysis carried out to estimate the overall effect size of this correlation.</div></div><div><h3>Results</h3><div>Ten studies were included in the review, including seven in meta-analysis. There was a statistically significant weak mother-child correlation in the level of alexithymia for total scores (<em>r</em> = 0.24, <em>p</em> = 0.01) and subscale scores (DIF <em>r</em> = 0.18, <em>p</em> = 0.02; DDF <em>r</em> = 0.15, <em>p</em> = 0.04; EOT <em>r</em> = 0.12, <em>p</em> = 0.006). In relation to fathers, there was a statistically significant weak correlation with total score (<em>r</em> = 0.16, <em>p</em> = 0.01) but not subscale scores. Rates of alexithymia were much higher in young people with mental and physical health diagnoses (12–46 %), compared with non-clinical populations (9 %), in keeping with previous research.</div></div><div><h3>Conclusion</h3><div>Alexithymia is common in adolescents with mental and physical health diagnosis, and there is a small but consistent correlation in child-parent alexithymia, in keeping with the understanding of a multifactorial cause for alexithymia. Future research should consider family-based interventions for alexithymia.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119855"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness and user-rated helpfulness of digital just-in-time adaptive interventions for psychological distress","authors":"Julia S. Yarrington ,&nbsp;Allison Metts ,&nbsp;Jose H. Vargas ,&nbsp;Diego D. Couto ,&nbsp;Thiago Marafon ,&nbsp;Zachary D. Cohen","doi":"10.1016/j.jad.2025.119878","DOIUrl":"10.1016/j.jad.2025.119878","url":null,"abstract":"<div><div>Digital just-in-time adaptive interventions (JITAIs), or interventions that can be offered in a context when support is needed most, represent a promising development for improving scalable, personalized interventions. However, the comparative efficacy of specific JITAIs has yet to be examined. The present study examines engagement with and usefulness of JITAIs provided through a mental health application, Youper. This study uses data from Youper users (<em>N</em> = 8323) collected between July and October of 2020. Users were randomized to one of nine cognitive or behavioral interventions, although the present study examined interactions with only six cognitive interventions (e.g., gratitude, mindfulness, cognitive restructuring). If users engaged with the intervention, they subsequently rated its helpfulness. Engagement was examined with logistic regression and user-rated helpfulness of JITAIs was explored through a multi-level model. A secondary analysis examined whether pre-intervention emotions moderated the results. Compared to acceptance-based interventions, users had significantly greater odds of engaging with cognitive restructuring, problem-solving, self-compassion, and gratitude interventions (all <em>p</em>s &lt; 0.001), but significantly lower odds of engaging with mindfulness-based interventions (<em>p</em> &lt; .001). Cognitive restructuring, gratitude, mindfulness, and problem-solving were rated as more helpful than acceptance (all <em>p</em>s &lt; 0.001). There was a non-significant difference between perceived helpfulness of self-compassion and acceptance (<em>p</em> &gt; .05). Pre-intervention emotions did not moderate effects (<em>p</em> &gt; .05). These results suggest that JITAIs, which can be implemented at the moment when users most need support, are helpful emotion regulation tools.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119878"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral skin temperature differentiates unipolar and bipolar depression","authors":"Ali Amad ,&nbsp;Yassine Ouzar ,&nbsp;Clémence Nineuil ,&nbsp;Fouad Boutaleb ,&nbsp;Emery Pierson ,&nbsp;Fabien D'Hondt ,&nbsp;Mohamed Daoudi","doi":"10.1016/j.jad.2025.119902","DOIUrl":"10.1016/j.jad.2025.119902","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119902"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations in the development of learning health networks for mood disorders.","authors":"Jessica M Lipschitz, Caleb Adler, Jorge Almeida, Shervin Assari, David Bond, Mason Breitzig, Ray DePaulo, Rif El-Mallakh, Jess Fiedorowicz, John Freshley, Gabriel Fries, Mark Frye, Fernando Goes, Robert Gonzalez, Rebekah Huber, Kay Jamison, Guodong Liu, Rodrigo Machado-Vieira, Pamela Mahon, Melvin G McInnis, Thomas Meyer, Youssef Nagy, John Nurnberger, Michael Ostacher, Sagar Parikh, Omar Pinjari, Kristin Raj, Matteo Respino, Marsal Sanches, Christopher Schneck, Manpreet Singh, Jair Soares, Steve Strakowski, Aimee Sullivan, Trisha Suppes, Michael Thase, Po Wang, Jeanette Waxmonsky, Deborah Yurgelun-Todd, Peter Zandi, Katherine E Burdick","doi":"10.1016/j.jad.2025.119904","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119904","url":null,"abstract":"<p><strong>Background: </strong>Learning Health Networks (LHNs), such as the one described in Savitz et al. (in press), involve employing a network of treatment centers to produce standardized data from routine clinical practice, produce knowledge from that data, and systematically use that knowledge to inform care. To date, there are limited examples of LHNs in psychiatry. It is essential to establish robust dialogue around best practices for building LHNs to advance precision medicine in psychiatry.</p><p><strong>Methods: </strong>A task group consensus on key elements of LHNs as applied to mood disorders was convened. Task group members reviewed current literature and ongoing LHN network efforts and evaluated opportunities and gaps within psychiatry broadly, and mood disorders specifically.</p><p><strong>Results: </strong>Task group members noted four key considerations for building LHNs for mood disorders. First, obtain qualitative and quantitative stakeholder input at every stage of development, specifically input from patients and patients' families, clinicians and health system leadership. Second, collect data on objective measures of functioning, such as neuropsychological testing, quality of life indicators, and blood-based markers of health, alongside more standard measures such as symptom severity. Third, carefully consider the details of how new evidence-based practices will be identified and implemented. Fourth, identify a plan for sustainability.</p><p><strong>Limitations: </strong>Literature was reviewed and discussed among expert task group members, but this was not a systematic review.</p><p><strong>Conclusions: </strong>With stakeholder input, data on functioning as well as symptom severity, thoughtful implementation strategies, and an eye to sustainability, LHNs represent an important opportunity for advancement in the treatment of mood disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119904"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Development of the Event-focused Repetitive Thoughts Questionnaire (ERTQ): A tool for assessing cognitive responses to stressful life events”","authors":"Parth Aphale ,&nbsp;Himanshu Shekhar ,&nbsp;Shashank Dokania","doi":"10.1016/j.jad.2025.119905","DOIUrl":"10.1016/j.jad.2025.119905","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119905"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A commentary on “Epstein–Barr virus infection increases the risk of depression: A cross-sectional study and Mendelian randomization analysis”","authors":"Jing Chen ,&nbsp;Lan Li ,&nbsp;Zheng Xue","doi":"10.1016/j.jad.2025.119896","DOIUrl":"10.1016/j.jad.2025.119896","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119896"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Balancing the 24-hour lifestyle: A population-based study on reducing mental health problems, self-injurious thoughts and behaviors among adolescents”","authors":"Jinyang Ye ,&nbsp;Yi Feng","doi":"10.1016/j.jad.2025.119894","DOIUrl":"10.1016/j.jad.2025.119894","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119894"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index mediates the relationship between depression and triglyceride levels: Evidence from a large national cohort","authors":"Bhaavyaa B. Shah ,&nbsp;Michael L. Thomas ,&nbsp;Michael J. McCarthy ,&nbsp;Alejandro D. Meruelo","doi":"10.1016/j.jad.2025.119889","DOIUrl":"10.1016/j.jad.2025.119889","url":null,"abstract":"<div><h3>Background</h3><div>Major Depressive Disorder (MDD) is linked to adverse metabolic outcomes, including elevated triglycerides and body mass index (BMI). However, mechanisms underlying this relationship—and their variation by age or sex—remain unclear.</div></div><div><h3>Methods</h3><div>Using data from over 200,000 participants in the All of Us Research Program, we examined associations between MDD (defined by SNOMED-coded diagnoses), BMI, and lipid biomarkers (triglycerides, HDL, LDL). Causal mediation analyses tested whether BMI mediated the MDD–triglyceride relationship, adjusting for age, sex, and alcohol intake. Sex differences and age-stratified effects (ages 25, 45, 65) were also explored.</div></div><div><h3>Results</h3><div>Individuals with MDD had higher BMI and triglyceride levels than those without (BMI SMD = 0.234; triglycerides SMD = 0.195; both <em>p</em> &lt; 0.001). BMI significantly mediated the MDD–triglyceride association (ACME = 5.46, 95 % CI [2.95, 8.17], <em>p</em> &lt; 0.001), accounting for 34.1 % of the total effect. The direct effect was not statistically significant (ADE = 10.55, <em>p</em> = 0.084). Mediation effects were consistent across sexes. Stronger mediation was observed at older ages (e.g., ACME = 6.07 at age 65, <em>p</em> &lt; 0.001) but not at younger ages (e.g., ACME = 5.09 at age 25, <em>p</em> = 0.076). Multiple imputation analyses confirmed these findings (ACME = 3.71, 95 % CI [3.09, 4.33], p &lt; 0.001; proportion mediated = 24.9 %). HDL and LDL levels differed modestly by MDD status.</div></div><div><h3>Conclusions</h3><div>BMI partially mediates the relationship between MDD and triglycerides, particularly in older adults. These results support integrating metabolic risk management into mental health care.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119889"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in sample selection and low adherence to psychotherapy manuals lead to unexpected results. A letter to the Editors on “Randomized controlled trial for the Attempted Suicide Short Intervention Program (ASSIP): An independent non-replication study”","authors":"Anja C. Gysin-Maillart ,&nbsp;Sebastian Walther ,&nbsp;Sara Lindström ,&nbsp;Anna Ehnvall ,&nbsp;Laurent Michaud ,&nbsp;Stéphane Saillant ,&nbsp;Gregor Berger ,&nbsp;Kristina Adorjan ,&nbsp;Simon Schwab","doi":"10.1016/j.jad.2025.119890","DOIUrl":"10.1016/j.jad.2025.119890","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119890"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}