Journal of affective disorders最新文献

{"title":"The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial","authors":"Murat Açik ,&nbsp;Funda Pınar Çakiroğlu ,&nbsp;Atilla Tekin ,&nbsp;Aslı Egeli","doi":"10.1016/j.jad.2025.03.097","DOIUrl":"10.1016/j.jad.2025.03.097","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to compare the effects of krill- and fish-oil interventions on clinical symptoms and metabolic risk factors in individuals with MDD.</div></div><div><h3>Methods</h3><div>In this randomized study, 57 adults diagnosed with MDD were allocated to receive krill-oil (520 mg EPA + DHA), fish-oil (600 mg EPA + DHA), or a placebo (soybean-oil) daily for 8 weeks. Anthropometric measurements, depression anxiety stress-21 (DASS-21) scale, and Hamilton depression rating scale (HDRS) were performed at baseline and 4 and 8 weeks. In addition, venous blood samples were collected at baseline and post-intervention to evaluate lipid and glycemic profiles, including fasting glucose, HbA1c, cholesterol, triglycerides, LDL-c, and HDL-c levels.SPSS and R Studio software programs were used for statistical analysis.</div></div><div><h3>Results</h3><div>A total of 50 participants completed the study, with 17 in each intervention group and 16 in the placebo. The mean HDRS scores decreased significantly in both the krill-oil (8.5 ± 1.2) and fish-oil groups (10.0 ± 1.2) compared to the placebo (<em>p</em> &lt; 0.001), indicating clinical symptom improvement. Furthermore, the interaction effect of group-by-time was found to be statistically significant (η2p = 0.273;p_time×group &lt; 0.001). Anxiety and distress scores decreased to similar levels after the post-intervention compared to baseline in krill- and fish-oil groups. Krill- and fish-oil supplementation increased plasma HDL-c and uric acid levels, but the group-by-time interaction effect was only observed at the HDL-c level (η2p = 0.238;p_time×group = 0.002). The mean HbA1c rates and plasma triglyceride levels of krill-oil recipients were lower after the post-intervention.</div></div><div><h3>Conclusion</h3><div>Krill- and fish-oil could be considered as a safe and effective adjuvant treatments for depression. However, there was no evidence of apparent superiority over each other.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 171-180"},"PeriodicalIF":4.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The different mediation role of habit features between intolerance of uncertainty and psychopathological symptom dimensions: A transdiagnostic perspective","authors":"Chenyu Yuan ,&nbsp;Yinqing Fan ,&nbsp;Chaoyi Wu ,&nbsp;Ang Hong ,&nbsp;Yangyinyin Ou ,&nbsp;Zhen Wang","doi":"10.1016/j.jad.2025.03.099","DOIUrl":"10.1016/j.jad.2025.03.099","url":null,"abstract":"<div><h3>Background</h3><div>Intolerance of uncertainty (IU) is a transdiagnosed vulnerability for many mental disorders. Habit is a potential cognitive construct that links to intolerance of uncertainty and symptom dimensions. This study adopted a transdiagnose perspective to investigate the mediation effect of habit features between symptom dimensions and intolerance of uncertainty in a Chinese community sample.</div></div><div><h3>Methods</h3><div>We recruited 4102 Chinese adults age ranged from 18 to 67 (M = 26.9, SD = 8.01) to extract psychopathological symptom dimensions and explore the mediation roles of habit features.</div></div><div><h3>Results</h3><div>The study extracted three symptom dimensions (compulsivity, addiction and affective stress dimension). All symptom dimensions, IU and habit features were significantly related (<em>p</em> &lt; 0.01). IU had a direct positive influence on all three dimensions (compulsivity: effect = 0.41; affective stress: effect = 0.58; addiction: effect = 0.13), it lso have an indirect positive impact via habit feature of automaticity (compulsivity: effect = 0.095; affective stress: effect = 0.062; addiction: effect = 0.050). Additionally, IU can positively influence compulsivity dimension (effect = 0.053) and negatively affective stress (effect = −0.026) dimension through routine feature of habit.</div></div><div><h3>Conclusions</h3><div>Higher level of IU can intensify symptom dimension by habit feature of automaticity, while habit feature of routine can alleviate affective stress dimension and aggravate compulsivity dimension.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 45-54"},"PeriodicalIF":4.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed niacin skin flush response identifies cognitive impairment in late-life depression","authors":"Yan Chen ,&nbsp;You Wu ,&nbsp;Dandan Wang ,&nbsp;Yang Yang ,&nbsp;Qianqian Guo ,&nbsp;Qi Qiu ,&nbsp;Chunlin Wan ,&nbsp;Xia Li","doi":"10.1016/j.jad.2025.03.095","DOIUrl":"10.1016/j.jad.2025.03.095","url":null,"abstract":"<div><h3>Objective</h3><div>This research aimed to inspect the discriminative and predictive utility of the niacin skin flush response (NSFR) in patients with late-life depression (LLD) with cognitive impairment (CI).</div></div><div><h3>Methods</h3><div>This study consisted of 86 LLD patients (46 with CI and 40 without CI), along with 22 Alzheimer's disease (AD) patients and 32 healthy elderly controls (HCs) as positive and negative controls, respectively. A subset of 74 LLD patients were reassessed after six months. The Montreal Cognitive Assessment (MoCA) was administered to assess cognitive capabilities. NSFR tests were performed using a modified protocol. Group differences in NSFR and clinical parameters were examined using multivariate ANOVA analysis. Model performance was evaluated using receiver operating characteristic (ROC) curves derived from NSFR measurements.</div></div><div><h3>Results</h3><div>NSFR showed a significant inverse correlation with cognitive functions in LLD patients (R = -0.456, <em>P</em> &lt; .001). Moreover, the parameter logEC₅₀, which quantifies the NSFR rate, was elevated in the LLD with CI group. LogEC₅₀ had an AUC of 0.767 (95 % CI: 0.667–0.867) in distinguishing LLD with CI from those without CI, which increased to 0.961 (95%CI:0.925–0.998) when combined with C- reactive protein. The predictive capacity of the baseline logEC₅₀ for cognitive prognosis (decline versus preservation) in LLD patients was statistically significant (AUC = 0.826, 95 % CI 0.731–0.921), which increased to 0.857 (95%CI:0.775–0.941) when combined with baseline MoCA.</div></div><div><h3>Conclusion</h3><div>A delayed NSFR represents a promising biomarker for identifying CI and predicting cognitive trajectories in patients with LLD. This study elucidates a novel methodology for the precise identification and prognostic evaluation of CI in LLD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 772-781"},"PeriodicalIF":4.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between inequalities in mental health resources and burdens of mental health disorders in 146 countries and territories: An observational study","authors":"Ying Shan ,&nbsp;Liyuan Liu ,&nbsp;Fei Wang ,&nbsp;Lixiang Yu ,&nbsp;Dongxu Liu ,&nbsp;Chao Zheng ,&nbsp;Qiufeng He ,&nbsp;Cheng Li ,&nbsp;Shixue Li ,&nbsp;Zhigang Yu","doi":"10.1016/j.jad.2025.03.094","DOIUrl":"10.1016/j.jad.2025.03.094","url":null,"abstract":"<div><h3>Background</h3><div>Mental health disorders impose a substantial social and economic burden. We conducted a comprehensive assessment of global mental health resource allocation and the associated burdens of mental health disorders, examining the relationship between these two factors.</div></div><div><h3>Methods</h3><div>We utilized data from the WHO Global Health Observatory and GBD 2021 to encompass 146 countries. We employed spatial autocorrelation analysis and Lorenz curves to characterize the spatial distribution. Additionally, we examined the association between mental health resources and the burdens of mental disorders using a generalized linear regression model (GLM).</div></div><div><h3>Results</h3><div>Countries and territories with higher income levels were more likely to have greater mental health resources (<em>p</em> &lt; 0.05). Globally, the average mental health resource allocation index (IMRA) was 18.14, and Moran's I was 0.509 (<em>p</em> &lt; 0.001). The Lorenz curve of mental health resources lay below the equality line, suggesting that these resources were more concentrated in countries and territories with higher HDI values. Between 2011 and 2021, the age-standardized incidence rate of all mental health disorders increased significantly (EAPC: 1.41 %, 95 % CI: 0.40 % to 2.53 %, <em>p</em> = 0.011). In multivariable GLM, a negative association was observed between the Index of IMRA and total mental health incidence.</div></div><div><h3>Conclusion</h3><div>Inequalities in mental health resources persist, and the burdens of mental disorders are increasing globally. Our findings underscore the critical need to reduce the overall burden of mental health disorders through enhanced allocation of prevention-oriented resources. Countries at different levels of human development face distinct challenges and priorities in mental health resource allocation.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 812-821"},"PeriodicalIF":4.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From parents to peers! Social support and peer attachment as mediators of parental attachment and depression: A Chinese perspective","authors":"Yunlin Sun ,&nbsp;Ke Wu ,&nbsp;Lei Wang ,&nbsp;Xingyu Zhao ,&nbsp;Qiangyan Che ,&nbsp;Yang Guo ,&nbsp;Yaru Guo ,&nbsp;Yifu Ji ,&nbsp;Xiaoming Li ,&nbsp;Kai Wang ,&nbsp;Rong Ye ,&nbsp;Fengqiong Yu","doi":"10.1016/j.jad.2025.03.043","DOIUrl":"10.1016/j.jad.2025.03.043","url":null,"abstract":"<div><h3>Background</h3><div>Secure attachment has been associated with a lower incidence of depressive symptoms in adolescents. Adolescence is an important period for attachment development as it shapes future attachment patterns. This study adopts a social support perspective to explore the transition from parental attachment to peer attachment, and its impact on reducing depression.</div></div><div><h3>Methods</h3><div>A sample of 7792 students from China, aged 11 to 19 years (mean = 15.19, SD = 2.564), completed three questionnaires: the Inventory of Parent and Peer Attachment, the Social Support Scale, and the Self-Depression Scale. SEM was used to analyze the mediating and moderating role of social support and peer attachment in the relationship between parental attachment and depression with gender as covariates.</div></div><div><h3>Results</h3><div>Peer attachment partially mediated the relationship between parental attachment and depression among Chinese adolescents (β = −0.17, <em>p</em> &lt; 0.001). Social support moderated the association between parental attachment and depression, indicating that higher levels of social support mitigate the negative influence of insecure parental attachment on adolescent depression (β = −0.02, <em>p</em> &lt; 0.05). Furthermore, social support mediated the relationship between peer attachment and parental attachment, suggesting that secure peer attachment and good social support jointly buffer against depressive symptoms in adolescents (β = −0.077, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The findings highlight important implications for developing targeted interventions to reduce adolescent depression. By recognizing the power of social support, we hope to provide valuable insights into practical strategies for addressing and alleviating adolescent depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 203-211"},"PeriodicalIF":4.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological differences in early-onset obsessive-compulsive disorder: A study of the glutamatergic system based on functional magnetic resonance spectroscopy","authors":"Yuqing Xiao ,&nbsp;Cigui Huang ,&nbsp;Jian Wang ,&nbsp;Yuqiao Lin ,&nbsp;Dongming Quan ,&nbsp;Huirong Zheng","doi":"10.1016/j.jad.2025.03.088","DOIUrl":"10.1016/j.jad.2025.03.088","url":null,"abstract":"<div><div>In this study, the combination of functional state magnetic resonance spectroscopy (fMRS) and cognitive tasks was used to conduct subgroup analyses on early-onset OCD (EO) and non-early-onset OCD (non-EO) and explore differences in the glutamatergic system and cognitive function among OCD subtypes. A total of 70 OCD and 30 healthy controls (HCs) underwent clinical evaluation and were subsequently divided into the EO or non-EO groups. Next, both resting and functional state MRS data were collected, with the anterior cingulate cortex (ACC) serving as the region of interest. Quantitative analysis of MRS data yielded precise neurometabolic concentrations, which were then statistically analyzed alongside inhibitory function, as measured by the Go-nogo task. The final analysis included 92 participants (22 EO-OCD, 41 non-EO OCD, and 29 HCs). EO-OCD patients had significantly higher Glx levels (<em>p</em> = 0.044) and lower GSH levels (<em>p</em> = 0.009) in the functional state compared to the non-EO group. Moreover, in the EO group, correlation analysis revealed a positive correlation between the functional state Glx levels and the average response time for errors in the nogo task (<em>r</em> = 0.526, <em>p</em> = 0.014). Additionally, resting-state GSH levels were positively correlated with total Y-BOCS scores (<em>r</em> = 0.854, <em>p</em> &lt; 0.001). Overall, early-onset OCD may represent a distinct subtype that requires targeted interventions, as evidenced by the imbalance in the glutamatergic system observed in early-onset OCD patients. Additionally, in early-onset patients, Glx concentration during activation was related to cognitive impairment.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 755-763"},"PeriodicalIF":4.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-utility of public health nurse-delivered group cognitive behavioural therapy for postpartum depression","authors":"Haley Layton ,&nbsp;Kathryn Huh ,&nbsp;Calan D. Savoy ,&nbsp;Feng Xie ,&nbsp;Ryan J. Van Lieshout","doi":"10.1016/j.jad.2025.03.078","DOIUrl":"10.1016/j.jad.2025.03.078","url":null,"abstract":"<div><h3>Background</h3><div>Postpartum depression (PPD) is associated with an increased risk of adverse outcomes for birthing parents, their children, and healthcare systems. Public health nurse (PHN)-delivered group cognitive behavioural therapy (CBT) can effectively treat PPD and has potential to be scaled, but its cost-effectiveness remains unknown. The purpose of this study was to examine the cost-utility of a PHN-delivered group CBT intervention for treating PPD added to treatment as usual (TAU) compared to TAU alone.</div></div><div><h3>Methods</h3><div>This economic evaluation was conducted alongside an RCT in Ontario, Canada. Birthing parents ≥18 years old with an infant ≤12 months and an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 10 were randomly assigned to receive PHN-delivered group CBT plus TAU or TAU alone. Costs were calculated based on healthcare service use over the 35-week trial period. The EQ-5D-3L was collected at baseline, 9 weeks, and 6 months later and used to calculate quality adjusted life years (QALYs). The incremental cost-effectiveness ratio (ICER) was calculated. Non-parametric bootstrapping was used to estimate uncertainty and generate a cost-effectiveness acceptability curve (CEAC).</div></div><div><h3>Results</h3><div>The intervention was associated with a 0.023 (95 % CI -0.058, 0.011) QALY gain and mean additional cost of $238 (95 % CI -$1749, $2227) compared to the control group. The ICER was $10,347 per QALY gained. At a willingness-to-pay of $50,000 for one QALY, PHN-delivered group CBT had a 75 % probability of being cost effective.</div></div><div><h3>Conclusions</h3><div>This trial-based cost-utility analysis found that PHN-delivered group CBT for treating PPD added to TAU may be cost-effective compared to TAU alone.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 673-679"},"PeriodicalIF":4.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying gender differences in the impact of internet addiction on adolescent depression: A causal inference approach","authors":"Clifford Silver Tarimo ,&nbsp;Yifei Feng ,&nbsp;Shiyu Jia ,&nbsp;Xiaoman Wu ,&nbsp;Weijia Zhao ,&nbsp;Yibo Zuo ,&nbsp;Yuhui Wang ,&nbsp;Yuefeng Bi ,&nbsp;Jian Wu","doi":"10.1016/j.jad.2025.03.079","DOIUrl":"10.1016/j.jad.2025.03.079","url":null,"abstract":"<div><h3>Background</h3><div>The rising prevalence of adolescent depression in China has raised concerns about internet influence. This study identified predictors of internet addiction (IA) and quantified its gender-specific impact on depression.</div></div><div><h3>Method</h3><div>In April–May 2023, 8176 adolescents from six (6) junior high schools in Henan, China, were randomly sampled. IA and depression were assessed via the 20-item internet addiction test (IAT) and 10-item Center for Epidemiologic Studies Depression (CESD-10) scale, respectively. IA's impact on depression was analyzed using four approaches: IPW (confounder weighting), DML (high-dimensional control), PSM (covariate balancing), and RA (residual adjustment).</div></div><div><h3>Results</h3><div>Among the males, 31.8 % reported depression and 17.7 % reported IA while females, 49.4 % reported depression and 21.3 % IA. The mean ages were 14.5 ± 0.94 (males) and 14.4 ± 0.93 (females). DML revealed the overall effect of 0.22 (95 % CI: 0.17–0.23; <em>p</em> &lt; 0.001), higher in males (95 % CI: 0.23, 95 % CI: 0.18–0.31) than females (0.17, 95 % CI: 0.11–0.23). IPW estimated an effect of 0.30 (95 % CI: 0.25–0.34; p &lt; 0.001), also higher in males (0.34, 95 % CI: 0.28–0.39) than females (0.29, 95 % CI: 0.23–0.36). PSM and RA yielded similar results. Predictors of IA included low self-esteem, history of negative life events, poor sleep quality, and one-child family status.</div></div><div><h3>Conclusion</h3><div>Internet addiction (IA) exacerbates adolescent depression, disproportionately affecting males. Addressing self-esteem, negative life events, poor sleep, and one-child family challenges can mitigate IA's effects. Gender-sensitive interventions, school-based programs, and parental guidance are critical.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 793-802"},"PeriodicalIF":4.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of body image on low mood: Insights from 154,183 adolescents across 43 countries","authors":"Geiziane Leite Rodrigues Melo ,&nbsp;Larissa Alves Maciel ,&nbsp;Rafaela Espírito Santo ,&nbsp;Cesar Agostinis-Sobrinho","doi":"10.1016/j.jad.2025.03.089","DOIUrl":"10.1016/j.jad.2025.03.089","url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the association between body image (BI) and feeling low mood using extensive and representative samples of school-aged adolescents from 43 countries.</div></div><div><h3>Methods</h3><div>A total of 154,183 participants (age 13.6 ± 1.6 years; 51.5 % girls) from these 43 countries from the 2017/2018 Health Behaviour in School-aged Children (HBSC) survey were included in the study. The BI, feeling low mood, physical activity (PA) and diet were self-reported.</div></div><div><h3>Results</h3><div>Overall, 31.8 % of participants reported higher levels of feel low mood, while 68.2 % reported lower levels. Adolescents who perceived themselves as “much too fat” reported the highest rates of feeling low mood (59.4 %), compared to those who viewed themselves as “about the right size” (26.5 %). Generalized linear mixed models indicated that perceiving oneself as “much too fat” (estimate = 0.703, <em>p</em> = 0.001) significantly increased the likelihood of feeling low mood. Be active and daily consumption of fruits and vegetables was linked to lower odds of feeling low mood, while frequent consumption of sweets (estimate = 0.272) raised these odds. Country-specific variations were evident, with higher rates of feeling low mood in Turkey (estimate = 1.612, <em>p</em> &lt; 0.001) and Italy (estimate = 1.207, p &lt; 0.001), and lower rates in the Netherlands and Serbia.</div></div><div><h3>Discussion</h3><div>Overall, BI, especially perceiving oneself as “much too fat,” is closely related to feelings of low mood in adolescents. This study underscores the multifaceted factors affecting adolescents' mood, including BI, diet, PA, age, sex, and country-specific contexts.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 607-614"},"PeriodicalIF":4.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an explainable machine learning model for predicting depression in adolescent girls with non-suicidal self-injury: A cross-sectional multicenter study","authors":"Ben Niu ,&nbsp;Mengjie Wan ,&nbsp;Yongjie Zhou","doi":"10.1016/j.jad.2025.03.080","DOIUrl":"10.1016/j.jad.2025.03.080","url":null,"abstract":"<div><div>Non-suicidal self-injury (NSSI) in adolescent girls is a critical predictor of subsequent depression and suicide risk, yet current tools lack both accuracy and clinical interpretability. We developed the first explainable machine learning model integrating multicenter psychosocial data to predict depression among Chinese adolescent girls with NSSI, addressing the critical need for culturally tailored risk stratification tools. In this cross - sectional observational study, our model was developed using data from 14 hospitals. We used five categories of data as predictors, including individual, family, school, psychosocial, and behavioral and lifestyle factors. We compared seven machine learning models and selected the best one to develop final model and the Shapley Additive exPlanations (SHAP) method were used to explain model prediction. The Random Forest (RF) model was compared against six other machine learning algorithms. We assessed the discrimination using the area under receiver operating characteristic (AUROC) with 95 % CIs. Using the development dataset (<em>n</em> = 1163) and predictive model building process, a simplified model containing only the top 20 features had similar predictive performance to the full model, the RF model outperformed six algorithms (AUROC = 0.964 [0.945–0.975]), demonstrating superior discriminative power and robustness. The top ten risk predictors were Borderline personality, Rumination, Perceived stress, Hopelessness, Self-esteem, Sleep quality, Loneliness, Resilience, Parental care, and Problem-focused coping. We developed a three-tiered, color-coded web-based clinical tool to operationalize predictions, enabling real-time risk stratification and personalized interventions. Our study bridges machine learning and clinical interpretability to advance precision mental health interventions for vulnerable adolescent populations.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 690-702"},"PeriodicalIF":4.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}