Journal of affective disorders最新文献

{"title":"Comparison of overall survival and healthcare resource utilization among patients with major depressive disorder with or without psychiatric emergency admission: A real-world study from Hungary.","authors":"Zoltan Rihmer, Peter Dome, Gyorgy Szekeres, Laszlo Feher, Peter Kunovszki, Judit Gimesi-Orszagh, Qian Cai, Antoine C El Khoury, Istvan Bitter","doi":"10.1016/j.jad.2024.12.014","DOIUrl":"10.1016/j.jad.2024.12.014","url":null,"abstract":"<p><strong>Background: </strong>Patients with major depressive disorder (MDD) hospitalized for psychiatric emergencies (PE) represent a high-risk population, requiring immediate intervention. Overall survival and healthcare resource utilization were evaluated among MDD patients with PE (MDD-PE) vs without PE (MDD-nonPE) using data from the Hungarian National Health Insurance Fund database (2009 to 2020).</p><p><strong>Methods: </strong>Patients with MDD were selected if they had at least (i) 2 records of MDD diagnosis, or (ii) 1 record of MDD diagnosis and 1 prescription of antidepressant within 90 days of each other between 01 January 2010 and 31 December 2020. MDD-PE patients should have an inpatient hospitalization in a psychiatric ward dedicated for acute treatment, and/or a visit to an emergency department with ≥1 psychiatric and/or suicidal condition among the discharge diagnoses. Patients in the MDD-PE and MDD-nonPE cohorts were matched using a 1:1 propensity score matching algorithm based on age, gender, location of residence, and selected pre-index comorbidities.</p><p><strong>Results: </strong>28,988 MDD-PE and 28,988 MDD-nonPE patients were included after propensity score matching. Overall survival was significantly shorter among MDD-PE vs matched MDD-nonPE patients (HR: 1.40, 95%CI: 1.33-1.48; p < 0.001). MDD-PE (vs matched MDD-nonPE) patients had significantly higher mean all-cause inpatient admissions (3.9 vs 1.4, p < 0.001) per patient per year (PPPY), and MDD-related inpatient admissions (2.3 vs 0.7, p < 0.001) PPPY with more days in hospital PPPY (all-cause: 65.4 vs 17.4 days; MDD-related: 25.9 vs 8.7 days).</p><p><strong>Conclusions: </strong>Findings emphasize the need for comprehensive care prioritizing increased vigilance for suicide risk and appropriate follow-up post-discharge among MDD-PE patients.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"184-190"},"PeriodicalIF":4.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of orexin antagonists for the management of major depressive disorder: A systematic review of randomized clinical trials.","authors":"Shakila Meshkat, Angela T H Kwan, Gia Han Le, Sabrina Wong, Kayla M Teopiz, Larry Wang, Joshua D Rosenblat, Taeho Greg Rhee, Bing Cao, Roger S McIntyre","doi":"10.1016/j.jad.2024.12.008","DOIUrl":"10.1016/j.jad.2024.12.008","url":null,"abstract":"<p><p>Orexin receptor antagonists are a group of medications primarily developed to treat insomnia. Preliminary studies support their efficacy in the treatment of depression. In this systematic review, we aim to evaluate the efficacy of orexin receptor antagonists for the treatment of major depressive disorder (MDD). Electronic databases were searched from inception to February 2024 to find relevant studies. Original studies in English that evaluated efficacy of orexin receptor antagonists were included. A total of five randomized clinical trials involving 498 participants were included. Seltorexant (20 mg) significantly decreased depression scores when compared to placebo, as measured by the Hamilton Depression Rating Scale (HDRS). In patients with inadequate responses to antidepressants, seltorexant (20 mg) also showed improvement in Montgomery-Ǻsberg Depression Rating Scale (MADRS) total scores compared to placebo. However, filorexant did not exhibit a significant difference in MADRS total scores compared to placebo. A separate study on seltorexant (40 mg) for MDD patients resulted in a non-significant decrease in depressive symptoms compared to placebo, as measured by the Quick Inventory of Depressive Symptomatology - Self-Report (QIDS-SR). Taken together, these findings highlight the potential of orexin receptor antagonists, particularly seltorexant, as a novel avenue for managing depressive symptoms in MDD. Further research is warranted to better understand their role in depression treatment and their safety profile.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"409-419"},"PeriodicalIF":4.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Fzd6 on intestinal flora and neuroinflammation in lipopolysaccharide-induced depression-like mice.","authors":"Wenlu Chen, Xiaoru Yan, Xiaona Song, Yiyan Yang, Xiaotang Wang, Guoqiang Xu, Tian Wang, Yaqi Liu, Zhao Fan, Guohua Song","doi":"10.1016/j.jad.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.011","url":null,"abstract":"<p><strong>Background: </strong>The gut microbiome is critical for the pathophysiology of depression, and inflammation is one of the factors contributing to depression. Fzd6 has been implicated in depression. This study aimed to elucidate the effects of the Fzd6 mutation on gut microbiota structure and the possible regulatory mechanisms involved in depression-associated neuroinflammation.</p><p><strong>Methods: </strong>Wild-type (Fzd6^WT) and Fzd6 mutant (Fzd6^Q152E) male mice were treated with lipopolysaccharide (LPS) for 7 days. Behavioral experiments were used to detect the behavioral changes of mice in each group, and the composition of intestinal flora and systemic inflammation levels of mice were further detected.</p><p><strong>Results: </strong>In LPS mice, the Fzd6 mutation enhanced depression-like behavior symptoms, increased the release of pro-inflammatory cytokines, decreased the release of anti-inflammatory cytokines, and caused intestinal flora disturbance. Subsequently, 16SrRNA sequencing revealed significant changes in the relative abundance of the inflammation-associated bacterial groups Ruminococcaceae and Lachnospiraceae in Fzd6^Q152E mice. In mice with depression, the levels of G protein-coupled receptors, GPR41 and GPR43, and glucagon-like peptide-1 (GLP-1) in the small intestine were down-regulated, and the expression of GLP-1 receptor (GLP-1R), peroxisome proliferators activated receptors gamma (PPAR-γ), and nuclear factor kappa-B inhibitor alpha (IκBα) in the hippocampus was also down-regulated, while the expression of nuclear factor kappa-B p65 (NF-κB p65) was up-regulated.</p><p><strong>Limitations: </strong>The size of the spleen was not studied in this model, and the Fzd6 mutation itself does not cause systemic inflammation such as IL-6.</p><p><strong>Conclusion: </strong>These results demonstrate that mutations in Fzd6 regulate the composition of the gut flora, which contributes to depression-associated inflammation.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life and its factors in Chinese people with depression and anxiety: A national multi-center cross-sectional study.","authors":"Ting Wang, Shuyong Zhang, Yating Yang, Biqi Zu, Chunying Pan, Juan Yin","doi":"10.1016/j.jad.2024.12.004","DOIUrl":"10.1016/j.jad.2024.12.004","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of depression and anxiety in Chinese population has been increasing in recently years, yet the health-related quality of life (HRQoL) of people with depression and anxiety remains unclear.</p><p><strong>Objective: </strong>To evaluate the HRQoL of individuals with depression and anxiety in China and to explore the factors influencing it.</p><p><strong>Methods: </strong>The study population was divided into a depressed group and non-depressed group, as well as an anxious group and non-anxious group. The EuroQol five-dimensional five-level questionnaire (EQ-5D-5L) was used to assess HRQoL in these individuals. Regression with the least absolute shrinkage and selection operator (Lasso) was applied separately to the datasets of the depressed and anxious populations for variable selection. A Tobit regression model was then used to analyze the relationship between various influencing factors and HRQoL in individuals with depression and anxiety.</p><p><strong>Results: </strong>A total of 7920 valid samples were collected from the PBICR database, including 1406 individuals with depression and 933 with anxiety. The HRQoL for individuals with depression and anxiety was estimated at 80.38 ± 17.17 and 80 ± 17.57, respectively. Among those with depression, a significant decrease in HRQoL was observed in individuals with debt (P = 0.021) and ex-smokers (P = 0.022) compared to their control groups. Health literacy (P < 0.001) and self-efficacy (P = 0.008) were identified as significant factors influencing HRQoL. For participants with anxiety, HRQoL was also lower among individuals with debt (P = 0.047) and ex-smokers (P = 0.033) compared to their control groups. Health literacy (P < 0.001) was a significant factor influencing HRQoL. Among individuals with depression (P = 0.006) and anxiety (P = 0.001), males had significantly higher HRQoL than females.</p><p><strong>Conclusion: </strong>Common factors influencing the HRQoL of both individuals with depression and those with anxiety include debt, gender, smoking status, and health literacy. Additionally, self-efficacy is a significant factor affecting the HRQoL of individuals with depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"241-250"},"PeriodicalIF":4.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human blood metabolites and risk of post-traumatic stress disorder: A Mendelian randomization study.","authors":"Yi Wei, Liyu Huang, Jie Sui, Chao Liu, Ming Qi","doi":"10.1016/j.jad.2024.12.029","DOIUrl":"10.1016/j.jad.2024.12.029","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic stress disorder (PTSD) is a debilitating chronic mental disorder that leads to reduced quality of life and increased economic burden. Observational studies have found an association between human blood metabolites and PTSD. Nonetheless, these studies have limitations and are subject to confounding factors as well as reverse causation. Herein, we employed a two-sample Mendelian randomization (MR) approach for the systematic analysis of the blood metabolites and PTSD causal link.</p><p><strong>Methods: </strong>Data for the human blood metabolome, cerebrospinal fluid (CSF) metabolome, and PTSD were obtained from publicly available summary-level genome-wide association studies (GWAS), respectively. The inverse variance weighted (IVW) approach represented the main analytic method for assessing exposure-outcome causal associations, employing multiple sensitivity analyses to verify the results' stability. In addition, replication and meta-analysis, steiger test and reverse MR analysis methods were performed to clarify further that these metabolites have independent causal effects on PTSD. Finally, the results of blood and CSF metabolomics analyses were synthesized to obtain biological markers with a causal link to PTSD.</p><p><strong>Results: </strong>Conclusively, we identified potential causal associations between six blood metabolites and PTSD. The sensitivity analyses elucidated the absence of pleiotropy or heterogeneity in the MR results. The Steiger test and reverse MR analysis did not reveal reverse causal associations, proving the robustness of our results. Combined blood and CSF metabolome analyses showed the same trend for theophylline.</p><p><strong>Conclusion: </strong>This study reveals a strong causal link between metabolites and PTSD, which can be used as a biomarker for clinical PTSD disease screening and prevention. This study also provides a new perspective on the mechanism of metabolite-mediated PTSD development by combining genomics and metabolomics.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"227-233"},"PeriodicalIF":4.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of cortical gyrification patterns in patients with panic disorder with and without comorbid generalized anxiety disorder.","authors":"Jiwan Moon, Hyun-Ju Kim, Chae Rim Song, Chongwon Pae, Sang-Hyuk Lee","doi":"10.1016/j.jad.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.001","url":null,"abstract":"<p><strong>Background: </strong>Lower functioning and higher symptom severity are observed when panic disorder (PD) co-occurs with generalized anxiety disorder (PD + GAD). No research on cortical gyrification patterns in the PD + GAD group has been conducted to date, which could show the alterations in brain connectivity in the extended fear network (EFN). This study aimed to investigate the characteristics of cortical gyrification in the PD + GAD group, compared to that in the PD without comorbid GAD (PD-GAD) group.</p><p><strong>Methods: </strong>This study included 90 patients with PD, with propensity score matching between the PD + GAD (n = 30) and PD-GAD groups (n = 60), and 65 healthy controls (HC). For clinical evaluation, we assessed the anxiety symptomatology, suicidality, and harm avoidance. The local gyrification index (LGI) was obtained from T1-weighted brain MRI data using FreeSurfer.</p><p><strong>Results: </strong>In the PD group compared to the HC, the hypergyrification involved the EFN. In the PD + GAD group compared to the PD-GAD group, hypergyrification was shown in the pathological worry-related brain regions. Within the PD + GAD group, significant positive correlations were observed between the superior frontal gyrus LGI values and suicidality scores, as well as between the superior parietal gyrus LGI values and harm avoidance levels.</p><p><strong>Limitations: </strong>Given the variability in cortical gyrification patterns, longitudinal studies are needed to assess the occurrence of hypergyrification in specific brain regions.</p><p><strong>Conclusions: </strong>This study is the first to demonstrate cortical gyrification patterns in the PD + GAD group compared to those in the PD-GAD group. Notably, the EFN and pathological worry-related brain regions have been implicated in the pathology of PD + GAD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"372 ","pages":"216-224"},"PeriodicalIF":4.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medial prefrontal cortex-periaqueductal gray circuit overcomes anxiety-like behavior in male mice following adversity.","authors":"Jiahui Qian, Wei Wu, Lianli Qiu, Xiang Liu, Yifeng Luo, Feng Chen, Wesley Surento, Yueqin Liu, Guangming Lu, Rongfeng Qi","doi":"10.1016/j.jad.2024.12.017","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.017","url":null,"abstract":"<p><strong>Background: </strong>Inescapable stress leads to various long-lasting physical and mental dysfunctions. Acute stress exposure is linked to a high risk of psychological disorders, such as anxiety disorders. The medial prefrontal cortex (mPFC) and periaqueductal gray (PAG) are anatomical regions associated with social information processing and emotional valence. However, it is unclear whether mPFC projections to the PAG are involved in anxiety behavior.</p><p><strong>Methods: </strong>In this study, an anxiety model by an inescapable foot shock was established. And used immunofluorescence, FosTRAP strategy, specific chemogenetics, optogenetics and behavior test to reveal that the stressful event increased the anxiety behavior of mice after exposure to foot shock and activation of mPFC-PAG circuitry can improve anxiety-like behavior and the locomotor behavior of mice.</p><p><strong>Results: </strong>Notably, FosTRAP results indicated that c-Fos expression in the PAG and mPFC is increased during foot shock, but inhibiting these brain regions did not significantly alleviate anxiety behavior. Additionally, chemogenetic activation of mPFC projections to the PAG improved anxiety-like behavior and locomotor activity in mice only during stress. Optogenetic activation of the mPFC-PAG circuitry increased the total distance traveled in the open field test and slightly increased the number of entries into the center area, while optogenetic inhibition slightly increased anxiety-like behavior in control mice.</p><p><strong>Limitation: </strong>The limitation of this study is that only the changes and regulations of mPFC-PAG of anxiety male animals were studied.</p><p><strong>Conclusions: </strong>Overall, our findings suggest that the valence-encoding mPFC-PAG circuit modulates anxiety, and that these projections may be potential targets for treatment of anxiety disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence, associated with the article entitled \"Too early to add lithium to drinking water? No association between lithium and suicides in a pre-registered Swiss study\" by Pichler et al. (https://doi.org/10.1016/j.jad.2024.08.239, JAD, 18201).","authors":"Takeshi Terao","doi":"10.1016/j.jad.2024.12.013","DOIUrl":"10.1016/j.jad.2024.12.013","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"225-226"},"PeriodicalIF":4.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns, delays, and associated factors of help-seeking behaviour for lifetime mood disorders and anxiety disorders: A national representative survey.","authors":"Shaoling Zhong, Chao Ma, Yueqin Huang, Tingting Zhang, Xiaofei Hou, Tak Ching Tai, Jie Yan, Yaqin Yu, Xiufeng Xu, Zhizhong Wang, Yifeng Xu, Tao Li, Guangming Xu, Xiangdong Xu, Limin Wang, Yongping Yan, Shuiyuan Xiao, Lingjiang Li, Zhaorui Liu, Liang Zhou","doi":"10.1016/j.jad.2024.12.010","DOIUrl":"10.1016/j.jad.2024.12.010","url":null,"abstract":"<p><strong>Background: </strong>Utilisation of health services is low and delayed among individuals with mood mental disorders and anxiety disorders, despite high disease burdens and available effective treatments. This study aims to examine patterns and delays in help-seeking and associated factors among individuals with lifetime disorder of mood disorders and/or anxiety disorders.</p><p><strong>Methods: </strong>We used data from the China Mental Health Survey (CMHS), a nationally representative multistage clustered-area probability sample study across 31 provinces. We assessed lifetime mental disorders and help-seeking behaviour using the Composite International Diagnostic Interview (CIDI). Logistic regression analyses were used to examine sociodemographic and clinical correlates of delay to seek health care.</p><p><strong>Results: </strong>Among 32,552 participants, we identified 3075 patients with lifetime mood and/or anxiety disorders; 486 (15.5 % [95 % CI: 13.6-17.5 %]) have sought health care. Of these, 163 (4.8 % [95 % CI: 3.7-6.3]) ever sought specialized mental health services. The delays to initial health care were 1.0 (IQR: 0-7.1), 1.9 (0-10.0), and 10.0 (1.0-22.1) years for depressive, bipolar, and anxiety disorders. Patients with comorbidities, later age of onset, and living in urban areas showed a higher propensity for help-seeking (all p < 0.05). Older cohort was associated with longer delays in seeking health care, while a later age of onset was associated with shorter delays (all p < 0.05).</p><p><strong>Limitations: </strong>The cross-sectional retrospective design and self-assessment approach may add bias.</p><p><strong>Conclusions: </strong>Failure and delays in help-seeking are common in China. National strategies are needed to promote health care utilisation.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"386-393"},"PeriodicalIF":4.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms mediate the association between dietary inflammatory index and sleep: A cross-sectional study of NHANES 2005-2014.","authors":"Rui Ren, Runnian Huang, Yi Li, Wenxu Wang, Xingyue Ye, Linze Xi, Ru Zhang, Yang Peng, Difei Wang","doi":"10.1016/j.jad.2024.12.020","DOIUrl":"https://doi.org/10.1016/j.jad.2024.12.020","url":null,"abstract":"<p><strong>Background: </strong>Sleep pattern (sleep duration, trouble sleeping, sleep disorder) is associated with both energy density dietary inflammatory index (EDII) and depression. However, whether depression mediates the EDII-sleep pattern relationship is unclear.</p><p><strong>Methods: </strong>14,305 participants from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2014 were included in this study. Weighted multivariable logistic regression and mediated effect analysis were conducted to analyze the associations between EDII, depression and sleep pattern.</p><p><strong>Results: </strong>In the regression model with full confounding variables adjusted, the OR (95 % CI) for the association between EDII and sleep pattern was 2.11 (1.44, 3.08). Similarly, comparing the highest to the lowest EDII scores, the association with depression yielded an identical OR of 2.62 (1.89, 3.64). Mediation models showed depressive symptoms mediated 24.06 % of the EDII-sleep pattern link. Analysis by sleep pattern subtypes found depressive symptoms mediated 18.22 % for sleep duration, 30.53 % for sleep disorder (both with substantial direct EDII effects), and 93.73 % for trouble sleeping, where EDII's direct impact was not considerable.</p><p><strong>Conclusion: </strong>Positive association of EDII with unhealthy sleep pattern is partly mediated by depression, and anti-inflammatory diet could be beneficial.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}