Journal of affective disorders最新文献

{"title":"Magnetic resonance spectroscopy studies in children and adolescents with depression: A systematic review and meta-analysis.","authors":"Hong Zhou, Yao Gao, Tao Dong, Jie Wang, Zhi-Fen Liu","doi":"10.1016/j.jad.2025.119747","DOIUrl":"10.1016/j.jad.2025.119747","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have focused on the levels of brain metabolites in patients with depression. However, there are relatively few studies on magnetic resonance spectroscopy (MRS) of adolescent depression and the related neurobiological mechanisms lack consistent conclusions. To summarize the nature of brain metabolite changes in adolescents with depression, we conducted meta-analyses of metabolite levels in proton magnetic resonance spectroscopy (¹H-MRS) studies.</p><p><strong>Methods: </strong>We searched the PubMed, Cochrane Library, Scopus, Embase, and Web of Science databases from January 1965 to December 2023. Heterogeneity across studies was evaluated using the Q and I² tests, and the random-effects model was used for analysis. Subgroup analyses were also conducted to explore potential sources of inconsistency.</p><p><strong>Results: </strong>A total of 26 studies involving 465 adolescent patients with depression and 409 healthy controls (HC) were included in this systematic review. N-acetyl aspartate (NAA) levels (SMD: -0.20, 95%CI: -0.34 to -0.05) were decreased in adolescents with depression when all brain areas were combined. In the dorsolateral prefrontal cortex white matter region, right-sided NAA (SMD: -0.76, 95 % CI: -1.36 to -0.15) and left-sided choline (Cho) levels (SMD: -0.54, 95 % CI: -0.96 to -0.12) were decreased. The levels of NAA (SMD: -0.35, 95 % CI: -0.65 to -0.05), Cho (SMD: -0.34, 95 % CI: -0.67 to -0.00) and creatine (Cr) (SMD: -0.50, 95 % CI: -0.96 to -0.03) in the anterior cingulate cortex (ACC) are reduced. The NAA/Cr levels (SMD: -1.67, 95 % CI: -3.29 to -0.05) in the left prefrontal cortex (PFC) are decreased.</p><p><strong>Conclusions: </strong>Our results suggest that the reduction in NAA levels throughout the brain regions, especially in the prefrontal cortex, among adolescent patients with depression may be due to neuronal loss. The decrease in Cr concentration indicates that using relative creatine concentration may affect the study results. The PFC and ACC may play an important role in adolescent depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119747"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between folate intake and suicidal ideation: NHANES 2005-2018 and Mendelian randomization.","authors":"Ling Feng, Shandie Li, Chaorui Li","doi":"10.1016/j.jad.2025.119730","DOIUrl":"10.1016/j.jad.2025.119730","url":null,"abstract":"<p><strong>Background: </strong>Previous findings indicated that there was an association between folate intake and suicidal behaviors. Nevertheless, whether folate intake influences suicidal ideation remains inconclusive. Consequently, this research focuses on investigating the link between folate intake and suicidal ideation.</p><p><strong>Methods: </strong>The data utilized came from the National Health and Nutrition Examination Survey (NHANES) database, with a coverage period of 2005-2018. We examined the correlation between folate intake and suicidal ideation by applying weighted logistic regression, restricted cubic spline (RCS) models, and subgroup analysis. Mendelian randomization (MR) was utilized as an instrumental variable method to evaluate the potential causality.</p><p><strong>Results: </strong>The NHANES analysis revealed a non-linear inverse relationship between folate intake and suicidal ideation (P for nonlinear: 0.014). After adjusting for all covariates, participants in the fourth quartile of folate intake demonstrated a 38 % diminished risk of suicidal ideation relative to those in the first quartile, for each incremental unit of folate intake (OR: 0.62, 95%CI: 0.44-0.89). Subgroup analysis revealed that the relationship between folate intake and suicidal ideation remained consistent across gender, race, smoking status, diabetes, hypertension and depression (P for interaction>0.05). Nevertheless, the Mendelian randomization (MR) analysis was unable to show causality between folate intake and suicidal ideation (OR: 0.944, 95%CI: 0.788-1.131, P: 0.533).</p><p><strong>Conclusions: </strong>An inverse connection was observed between folate intake and suicidal ideation, but no causal relationship was established.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119730"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: \"Association between oral microbiome and depression: A population-based study\".","authors":"Shiyuan Wu, Muze Huang","doi":"10.1016/j.jad.2025.119897","DOIUrl":"10.1016/j.jad.2025.119897","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119897"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Evaluating the impact of adjunct bright light therapy on subjective sleep quality in major depressive disorder\" [J. Affect. Disord. 348 (2024) 175-178].","authors":"Lorenzo Fregna, Francesco Attanasio, Cristina Colombo","doi":"10.1016/j.jad.2025.119688","DOIUrl":"10.1016/j.jad.2025.119688","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119688"},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Increased prevalence of depression, anxiety, and adjustment and somatoform disorders in transsexual individuals\" [J. Affect. Disord. 274 (2020) 482-485].","authors":"Marcel Konrad, Karel Kostev","doi":"10.1016/j.jad.2025.119812","DOIUrl":"10.1016/j.jad.2025.119812","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119812"},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The changing prevalence of ADHD? A systematic review.","authors":"Alex F Martin, G James Rubin, M Brooke Rogers, Simon Wessely, Neil Greenberg, Charlotte E Hall, Angie Pitt, Poppy Ellis Logan, Rebecca Lucas, Samantha K Brooks","doi":"10.1016/j.jad.2025.119427","DOIUrl":"10.1016/j.jad.2025.119427","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) and changes in demand for related healthcare services is crucial for effective healthcare policy and resource allocation. Clinicians, teachers and charities have reported increasing demand for ADHD assessments in recent years, overwhelming support systems. This review synthesises post-2020 studies of ADHD prevalence and incidence.</p><p><strong>Methods: </strong>We conducted systematic searches in Web of Science, Embase, Medline, Global Health, and PsycInfo using terms relating to ADHD and prevalence. Additional sources included public health databases, Google, and study reference lists. Studies were included if they contained original data relating to general population rates of ADHD and we extracted data relating to methods of assessment and measures of prevalence and incidence. We followed PRISMA and synthesis without meta-analysis (SWiM) guidelines.</p><p><strong>Results: </strong>Forty studies across 17 countries, with one study spanning 42 countries, were reviewed. No significant rise in ADHD prevalence was found, although incidence was found to vary during the COVID-19 pandemic. Only four of the included studies were at low risk of bias.</p><p><strong>Limitations: </strong>There are substantial limitations in the quality of the literature included in this review. Due to significant delays in reporting prevalence data, estimates from previous reviews may be inaccurate. There is a lack of healthcare data and no school-level data.</p><p><strong>Conclusions: </strong>Significant research gaps exist in determining ADHD prevalence and incidence. The highest quality findings do not suggest an increase in prevalence since 2020 but indicate some variability in incidence during the COVID-19 pandemic. Further research is urgently needed to guide clinical practice and public health policy.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119427"},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Is 'minimally adequate treatment' really adequate? investigating the effect of mental health treatment on quality of life for children with mental health problems\" [J. Affect. Disord. 276 (2020) 327-334].","authors":"Jemimah Ride, Li Huang, Melissa Mulraney, Harriet Hiscock, David Coghill, Michael Sawyer, Emma Sciberras, Kim Dalziel","doi":"10.1016/j.jad.2025.119691","DOIUrl":"10.1016/j.jad.2025.119691","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119691"},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High stakes and high scores: Investigating the World Health Organization criteria for gambling and gaming disorders in a nationally representative sample.","authors":"Halley M Pontes","doi":"10.1016/j.jad.2025.120360","DOIUrl":"https://doi.org/10.1016/j.jad.2025.120360","url":null,"abstract":"<p><p>Gambling disorder and gaming disorder are increasingly recognized as significant contributors to affective disorders, highlighting the need to better understand their diagnostic frameworks. The aim of this study was to compare \"core\" and \"peripheral\" diagnostic criteria for gaming disorder and, for the first time, evaluate these distinctions within gambling disorder. A nationally representative sample of 1074 British adults completed online assessments of gambling and gaming disorders per the World Health Organization's (WHO) eleventh revision of the International Classification of Diseases (ICD-11). Condition Inferential Tree analyses identified which criteria best predicted high-risk behavior. Prevalence was low for gambling disorder (0.49 %) and gaming disorder (0.30 %), though high-risk cases were more frequent (2.47 % and 2.27 %, respectively). In gambling disorder, the experience of significant distress/impairment (criterion 4), increased priority (criterion 2), and continuation/escalation (criterion 3) emerged as core criteria while impaired control (criterion 1) was peripheral. For gaming disorder, the experience of significant distress/impairment (criterion 4), continuation/escalation (criterion 3), and impaired control (criterion 1) were core and increased priority (criterion 2) peripheral. It is feasible to distinguish core from peripheral criteria in both disorders, but doing so requires a careful, severity-sensitive approach. The findings imply that distinguishing core from peripheral diagnostic criteria in gambling and gaming disorders provides a useful severity-sensitive framework that clarifies their links with affective disorders. This precision helps clinicians target the symptoms most likely to worsen mood dysregulation and guides research into shared mechanisms, improving prevention and treatment for comorbid affective and behavioral disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120360"},"PeriodicalIF":4.9,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the potential association between new oral anticoagulants and anxiety symptoms adverse events: Evidence from a real-world analysis.","authors":"Zhifang Deng, Ke Yang, Han Xiao, Hongjian Gong, Xiaonan Cai, Liqin Hu, Kun Ni, YanQiang Xiong, Wenqi Gao","doi":"10.1016/j.jad.2025.120355","DOIUrl":"https://doi.org/10.1016/j.jad.2025.120355","url":null,"abstract":"<p><strong>Objective: </strong>Healthcare professionals should be more concerned about the psychiatric status of patients on long-term maintenance anticoagulation therapy. Therefore, the aim of this study was to assess the potential risk association between new oral anticoagulants (NOACs) and psychiatric disorder adverse event through data mining in the FDA Adverse Event Reporting System (FAERS).</p><p><strong>Methods: </strong>This is a retrospective study of pharmacovigilance data from the FAERS. Safety signals for NOACs-associated asAEs were quantified by reporting the ratio of odds ratios (ROR) and information components (IC₀₂₅), and the weibull shape parameter (WSP) test was used for statistical analyses of time to onset (TTO).</p><p><strong>Results: </strong>Only apixaban was positively associated with psychiatric adverse events (n = 16,978, ROR = 1.48, IC₀₂₅ = 0.50). There were 1147 reports of apixaban-related adverse events involving anxiety symptoms, with anxiety (n = 1096) having the highest number of PTs and mixed anxiety and depression disorders (n = 12, ROR = 12.31, IC₀₂₅ = 1.94) being the strongest-signaling PT. Patients presenting with anxiety symptoms were predominantly from the U.S., with the majority of patients being female (n = 566) and over the age of 65 (n = 483). The median time to anxiety symptoms after apixaban treatment was 40.5 days, and the WSP test identified apixaban as a randomized failure type.</p><p><strong>Conclusion: </strong>Long-term use of apixaban might be associated with an increased risk of anxiety symptoms, and healthcare professionals need to pay more attention to the emotional state of patients on long-term maintenance anticoagulation therapy.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120355"},"PeriodicalIF":4.9,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered brain activity mediates the correlation between childhood trauma and aggression in youths with internet gaming disorder.","authors":"Shijie Chen, Hongwei Wen, Yuhong Zhou, Yuejiao Zhang, Xuemei Gao","doi":"10.1016/j.jad.2025.120357","DOIUrl":"10.1016/j.jad.2025.120357","url":null,"abstract":"<p><strong>Background: </strong>Childhood trauma is a recognized risk factor for affective dysregulation and aggressive behavior in adolescents with Internet Gaming Disorder (IGD). However, the neurobiological pathways linking trauma to aggression in IGD remain poorly understood. This study aims to investigate how childhood trauma affects aggressive behavior in adolescents with IGD through specific neurobiological mechanisms.</p><p><strong>Method: </strong>We recruited 111 adolescents categorized into IGD with childhood trauma (IGD-CT, n = 43), IGD without trauma (IGDN, n = 31), and healthy controls (HC, n = 37). Using resting-state fMRI, we computed amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) to compare spontaneous brain activity. Then we correlated the regional ALFF/fALFF with levels of childhood trauma (CTQ-SF score) and aggression. Finally, we conducted a mediation analysis to examine whether brain activity modulates the relationship between childhood trauma and aggression in youths with IGD.</p><p><strong>Results: </strong>The IGD-N group showed significantly lower fALFF compared with the IGD-CT group，they also had significant differences compared to the HC group. Furthermore, the mean fALFF in the left precuneus was positively correlated with CTQ-SF (r = 0.321, p = 0.008) and reactive aggression (RA; r = 0.396, p = 0.001) scores. Importantly, the mean fALFF in the left precuneus partially mediated the correlation between CTQ-SF and RA scores (effect proportion of 28.18 %).</p><p><strong>Conclusion: </strong>Our study identifies the left precuneus as a critical neural region where childhood trauma uniquely impacts aggression in adolescents with IGD. The findings highlight the necessity for targeted interventions in IGD with trauma histories, providing potential avenues to reduce aggression in at-risk adolescents affected by both trauma and gaming addiction.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120357"},"PeriodicalIF":4.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}