Journal of affective disorders最新文献

{"title":"Comparing the effects of ECT and intravenous ketamine in psychiatric patients with major depressive episodes","authors":"Julia Myerson ,&nbsp;Katrina A. Rufino ,&nbsp;Sanjay J. Mathew ,&nbsp;Marie Fletcher ,&nbsp;Neil Puri ,&nbsp;Hyuntaek Oh","doi":"10.1016/j.jad.2025.119727","DOIUrl":"10.1016/j.jad.2025.119727","url":null,"abstract":"<div><h3>Background</h3><div>Electroconvulsive therapy (ECT) and intravenous (IV) ketamine are treatments used for severe depression and/or treatment-resistant depression (TRD). ECT is considered one of the most effective treatments for severe depression, although there is debate within the field regarding the effectiveness between ECT and IV ketamine in comparable TRD patient groups.</div></div><div><h3>Methods</h3><div>This retrospective chart review of open-label, nonrandomized treatment from a psychiatric hospital compared the effects of up to three weeks of ECT and IV ketamine in patients with major depressive episodes (MDEs). Our cohort included 146 inpatients and outpatients aged 18 to 74 years old. 94 patients received subanesthetic IV ketamine infusions 2 times a week, and 52 patients received ECT treatment 2–3 times a week. The primary outcome measure was the Montgomery-Asberg Depression Rating Scale (MADRS).</div></div><div><h3>Results</h3><div>Overall on the MADRS, 45.2 % of participants showed clinical symptom change between the beginning of treatment compared to the end of treatment, while 54.8 % did not. Reliable change index (RCI) analysis indicated 58.9 % showed significant symptom change, while 41.1 % did not. Chi-Square tests revealed significant associations between treatment type and clinical symptom change on the MADRS, with patients who received ECT showing greater symptom improvement compared to those who received ketamine (<em>p</em> &lt; .05). Response rates of ECT and ketamine were 67.3 % and 45.7 %, respectively, whereas remission rates for ECT and ketamine were 60.0 % and 46.1 %, respectively.</div></div><div><h3>Conclusions</h3><div>ECT demonstrated the more robust antidepressant effects compared to ketamine. Randomized comparative trials are required to gain a better understanding of these modalities.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119727"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term mental health disorders and suicidal behaviors linked to excessive vomiting during pregnancy: Evidence from the UK biobank","authors":"Xiaona Na ,&nbsp;Xijie Wang ,&nbsp;Din Son Tan,&nbsp;Yufeng Tan,&nbsp;Celi Yang,&nbsp;Junhan Zhang,&nbsp;Yucheng Yang,&nbsp;John S. Ji,&nbsp;Ai Zhao","doi":"10.1016/j.jad.2025.119706","DOIUrl":"10.1016/j.jad.2025.119706","url":null,"abstract":"<div><h3>Background</h3><div>The long-term effect of excessive vomiting during pregnancy (EVP) on women's mental health remains unclear. We aimed to investigate the association of EVP with the risks of mental disorders and suicide-related behaviors, and the potential influence of adverse pregnancy outcomes (APOs).</div></div><div><h3>Method</h3><div>267,925 female participants without a prior history of mental disorders at baseline were recruited from the UK Biobank Study. Multivariable Cox proportional hazards models were used to estimate the associations between EVP and the risk of mental disorders and suicide-related behaviors. Mediation and network analyses were conducted to assess the role of other APOs.</div></div><div><h3>Results</h3><div>A total of 267,925 participants with a mean baseline age of 57.0 years were included in the primary analysis. Of these, 409 (0.15 %) reported experiencing EVP. During a median (Q1, Q3) follow-up time of 13.6 years, 33,526 (12.5 %) participants developed mental disorders, and 976 (0.4 %) experienced suicide-related behavior. EVP was associated with a higher risk of any mental disorders (adjusted Hazard Ratio [AHR]: 1.889, 95 % CI: 1.480, 2.412), Schizophrenia (AHR: 4.659, 95 % CI: 1.717, 12.645), mood disorders (AHR: 1.748, 95 % CI: 1.275, 2.397), and stress-related disorders (AHR: 2.088, 95 % CI: 1.481, 2.943). Pregnancy loss, gestational diabetes, hemoglobin levels, and the neutrophil-to-lymphocyte ratio mediate these associations. Mood disorders was a core node linking mental disorders to suicide-related behaviors.</div></div><div><h3>Conclusions</h3><div>EVP is associated with an increased risk of various mental disorders. Long-term mental health surveillance in women experiencing EVP is important, while further exploration on the underlying mechanism is required.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119706"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysfunctional parenting and suicidal ideation: The moderating role of hostility","authors":"Carola Dell'Acqua ,&nbsp;Claudio Imperatori ,&nbsp;Daniela Palomba ,&nbsp;Rita B. Ardito ,&nbsp;Benedetto Farina ,&nbsp;Mauro Adenzato ,&nbsp;Giuseppe A. Carbone ,&nbsp;Aurelia Lo Presti ,&nbsp;Elena De Rossi ,&nbsp;Giorgia Allegrini ,&nbsp;Simone Messerotti Benvenuti","doi":"10.1016/j.jad.2025.119695","DOIUrl":"10.1016/j.jad.2025.119695","url":null,"abstract":"<div><div>Childhood maltreatment stemming from dysfunctional parenting is a well-established risk factor for suicidal ideation. In turn, dysfunctional parenting has been linked to an increased tendency to develop hostility, which often relates to self-directed aggression and suicide. However, the interactive role of hostility in shaping the relationship between dysfunctional parenting and suicidal ideation remains largely understudied, as do the distinct contributions of maternal and paternal dysfunctional parenting to these associations. The present cross-sectional study sought to address these gaps by investigating the moderating role of hostility in the association between maternal and paternal dysfunctional parenting and suicidal ideation in a large sample of young adults (<em>N</em> = 683, 539 F). Moderation analyses showed that, in individuals with greater paternal dysfunctional parenting, higher levels of hostility were associated with greater suicidal ideation, whereas lower levels of hostility were linked to reduced suicidal ideation. Among those with greater maternal dysfunctional parenting, only the mitigating role of lower hostility levels on suicidal ideation remained significant. Given that dysfunctional parenting is a maladaptive interpersonal dynamic and that hostility exacerbates broader interpersonal difficulties, these findings underscore the critical role of the social domain in shaping suicidal ideation. Clinical interventions that target hostility in young adults with a history of dysfunctional parenting may be effective in mitigating suicide risk.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119695"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of collaborative care model treatment for depression and anxiety on cardiovascular risk factors using electronic health record data","authors":"Allison J. Carroll ,&nbsp;Sarah E. Philbin ,&nbsp;Olutobi A. Sanuade ,&nbsp;Emily S. Fu ,&nbsp;Andrew D. Carlo ,&nbsp;Havisha Pedamallu ,&nbsp;Saneha Borisuth ,&nbsp;Lisa J. Rosenthal ,&nbsp;Jeffrey T. Rado ,&nbsp;Neil Jordan ,&nbsp;Inger E. Burnett-Zeigler ,&nbsp;C. Hendricks Brown ,&nbsp;Justin D. Smith","doi":"10.1016/j.jad.2025.119720","DOIUrl":"10.1016/j.jad.2025.119720","url":null,"abstract":"<div><h3>Background</h3><div>Primary care patients with depression or anxiety are at higher risk for cardiovascular disease. Those who engage in integrated mental health treatment may also improve their cardiovascular health.</div></div><div><h3>Methods</h3><div>We conducted secondary analysis of electronic health record-extracted data related to a pragmatic, implementation trial of the collaborative care model for depression and anxiety (CoCM; <span><span>NCT04321876</span><svg><path></path></svg></span>). Primary care patients with elevated depressive/anxiety symptoms (N = 3252) in 11 primary care clinics were classified as CoCM Patients (n = 718), Not Referred to CoCM (n = 1348), or Not Engaged in CoCM (n = 1459). Cardiovascular health measures included blood pressure (BP; mmHg), total cholesterol (mg/dL), HbA1c (%), and body mass index (BMI; kg/m²). Primary analyses were linear regressions evaluating associations of CoCM treatment (vs. Not Referred, vs. Not Engaged) with changes in cardiovascular health, adjusted for demographics, cardiovascular diagnoses, and medications.</div></div><div><h3>Results</h3><div>At baseline, CoCM Patients had poorer cardiovascular health than Not Referred (higher systolic BP, total cholesterol, BMI) and better cardiovascular health than Not Engaged (lower total cholesterol, HbA1c). CoCM Patients, vs. Not Referred, had small decreases in total cholesterol (B = −0.44, 95 % CI: −0.72, −0.17) and increases in BMI (B = 0.18, 95 % CI: 0.03, 0.34). CoCM Patients did not differ from Not Engaged patients on cardiovascular health outcomes (all <em>p</em>s &gt; 0.05).</div></div><div><h3>Discussion</h3><div>Differences in cardiovascular health profiles were evident prior to treatment. Patients who bengaged in CoCM treatment, compared to patients not referred to CoCM, evidenced small improvements in total cholesterol and increases in BMI. Widespread implementation of integrated mental health treatment may have implications for population cardiovascular health.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119720"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substance use disorders in outpatients with bipolar disorder and pain complaints","authors":"J. Chabert ,&nbsp;R. Icick ,&nbsp;J. Cabé ,&nbsp;X. Moisset ,&nbsp;O. Godin ,&nbsp;S. Gard ,&nbsp;B. Aouizerate ,&nbsp;J. Loftus ,&nbsp;V. Aubin ,&nbsp;A. Lefrere ,&nbsp;C. Dubertret ,&nbsp;P. Roux ,&nbsp;M. Polosan ,&nbsp;T. Schwitzer ,&nbsp;B. Etain ,&nbsp;R. Moirand ,&nbsp;E. Olié ,&nbsp;E. Haffen ,&nbsp;M. Leboyer ,&nbsp;P. Courtet ,&nbsp;L. Samalin","doi":"10.1016/j.jad.2025.119693","DOIUrl":"10.1016/j.jad.2025.119693","url":null,"abstract":"<div><h3>Introduction</h3><div>Pain and substance use disorders (SUDs) are common in bipolar disorder (BD), yet the associations between these comorbid conditions are poorly understood. Our hypotheses were: (1) the frequency of SUDs may vary according to pain intensity in individuals with BD, (2) individuals with BD, pain and SUDs may have specific characteristics, and (3) clinical variables could explain the associations between pain and SUDs.</div></div><div><h3>Method</h3><div>We included outpatients from the FACE-BD cohort with a lifetime diagnosis of BD type I or II. Current pain was categorized using one item of the EQ-5D-5L scale as “no pain”, “mild pain”, “moderate pain”, and “severe or extreme pain”. Associations between pain level and other variables were tested using bivariate analyses, while multiple regression was conducted to characterize individuals with BD, pain and relevant SUDs. Finally, path analysis was performed to examine whether clinical variables could explain the associations between pain and relevant SUDs.</div></div><div><h3>Results</h3><div>Among the 1897 BD participants, 927 reported any pain (48.9 %). Among SUDs, higher pain levels were only associated with a history of lifetime alcohol use disorder (AUD). Only individuals with both AUD and moderate to extreme pain had a greater risk of having a history of lifetime anxiety disorder and panic disorder. In path analysis, the association between lifetime AUD and pain was partly mediated by current levels of depression, anxiety, and affective lability.</div></div><div><h3>Conclusion</h3><div>Our study highlights multiple associations in individuals with BD between the intensity of reported pain and history of lifetime AUD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119693"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety symptom trajectories and subsequent suicidal ideation among patients with major depressive disorder: A longitudinal study in China","authors":"Ruiying Chen ,&nbsp;Yan Chen ,&nbsp;Yanzhi Li ,&nbsp;Wenjing Zhou ,&nbsp;Wenjian Lai ,&nbsp;Subinuer Yiming ,&nbsp;Qindan Zhang ,&nbsp;Chengxi Wen ,&nbsp;Yuhua Liao ,&nbsp;Huimin Zhang ,&nbsp;Yifeng Liu ,&nbsp;Wanxin Wang ,&nbsp;Lan Guo ,&nbsp;Ciyong Lu ,&nbsp;Xue Han","doi":"10.1016/j.jad.2025.119704","DOIUrl":"10.1016/j.jad.2025.119704","url":null,"abstract":"<div><h3>Background</h3><div>To examine the longitudinal associations between different anxiety symptom trajectories and subsequent suicidal ideation (SI) among patients with major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>We used data from patients with MDD in the Depression Cohort in China. At baseline, 4, 8, and 12 weeks, anxiety symptoms were assessed using the Generalized Anxiety Disorder 7-item Scale, and trajectories were identified using latent class trajectory models. At 12, 24, and 48 weeks, SI was assessed using the Beck Scale for Suicide Ideation.</div></div><div><h3>Results</h3><div>We included 718 participants with a median (IQR) age of 26.0 (22.3, 31.0) years, among whom 489 (68.1 %) were female. Five trajectories of anxiety symptoms were identified: persistent mild (25.1 %), rapidly decreasing (30.1 %), persistent moderate (21.7 %), slowly decreasing (10.3 %), and persistent severe (12.8 %). Compared to the persistent mild anxiety symptom trajectory, the rapidly decreasing anxiety symptom trajectory was significantly associated with lower levels of SI (<em>β</em> coefficient, −0.186; 95 % confidence interval [CI], −0.296 to −0.075). Conversely, the persistent moderate anxiety symptom trajectory (<em>β</em> coefficient, 0.126; 95 % CI, 0.03 to 0.249) and persistent severe anxiety symptom trajectory (<em>β</em> coefficient, 0.334; 95 % CI, 0.185 to 0.482) were associated with higher levels of SI. No statistically significant association was found for the slowly decreasing anxiety symptom trajectory (<em>β</em> coefficient, 0.051; 95 % CI, −0.101 to 0.202).</div></div><div><h3>Limitations</h3><div>Reporting bias; Selection bias; Observational design; Generalizability.</div></div><div><h3>Conclusions</h3><div>Among patients with MDD, achieving reductions in anxiety symptoms may mitigate suicidal risk, and attention should be paid to the suicidal risk associated with anxiety symptoms, particularly when symptoms remain severe in the longitudinal follow-up.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119704"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling nature and nurture: Exploring the genetic background of depressive symptoms in the absence of recent stress exposure using a GWAS approach","authors":"Berta Erdelyi-Hamza ,&nbsp;Dora Torok ,&nbsp;Sandor Krause ,&nbsp;Nora Eszlari ,&nbsp;Gyorgy Bagdy ,&nbsp;Gabriella Juhasz ,&nbsp;Xenia Gonda","doi":"10.1016/j.jad.2025.119731","DOIUrl":"10.1016/j.jad.2025.119731","url":null,"abstract":"<div><h3>Background</h3><div>Depression triggered by stress exposure versus depression appearing independently of it are two distinct subtypes. Analyzing their genetic background separately may bring us closer to decreasing the noise stemming from heterogeneity. We focused on the genetic background of depressive symptoms appearing in the absence of recent stress exposure with a genome-wide analysis approach and to reveal biological connections between genetic background, brain functioning, and tissue specific differences.</div></div><div><h3>Methods</h3><div>We included nearly 200,000 subjects reporting no stressful life events in the past two years with data on current depressive symptom severity. Following genotyping and quality control, 6,076,829 genetic variants were analyzed. GWAS results were evaluated on SNP, gene, and gene-set levels.</div></div><div><h3>Results</h3><div>64 SNPs with suggestive significance were identified, one SNP (rs60939828 <em>p</em> = 5.92 × 10⁻¹¹), located in <em>DCC</em> survived Bonferroni correction. <em>DCC</em> (<em>p</em> = 4.16 × 10⁻¹⁰) was also among three genes significant in gene-level associations. We identified tissue-specific upregulation in relevant brain areas where the more significantly a gene was associated with depressive symptoms, the higher it was expressed in brain areas including the cerebellar hemisphere (<em>p</em> = 4.0131 × 10⁻⁵), cerebellum (<em>p</em> = 1.79 × 10⁻⁵), frontal cortex (<em>p</em> = 2.9 × 10⁻⁴), cortex (<em>p</em> = 3.4 × 10⁻⁴), and anterior cingulate cortex (<em>p</em> = 9 × 10⁻⁴). Heritability estimation analysis revealed a 7.3 % heritability.</div></div><div><h3>Conclusion</h3><div>Our findings contribute to separating subtypes of depression on a genetic level. Future studies need to compare our results to findings in depression developing following exposure to severe stress to see what genetic markers and implicated pathways may separate these fundamentally distinct subtypes of depressive symptoms, paving the way for precision guidelines for diagnosing and treating depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119731"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of embodied sense of self in the relationship of childhood abuse types to distress and fear","authors":"Laura E. Ong,&nbsp;Brandon M. Davis,&nbsp;Ashley M. Horodyski,&nbsp;Travis A. Cole,&nbsp;Holly K. Orcutt","doi":"10.1016/j.jad.2025.119698","DOIUrl":"10.1016/j.jad.2025.119698","url":null,"abstract":"<div><div>Theoretical models suggest that childhood abuse erodes embodied sense of self (ESS), a multidimensional entity that encompasses both subjective embodied experience and narrative identity. However, no studies have evaluated the impacts of childhood abuse types on the minimal and narrative selves simultaneously or examined the role of this integrated sense of self in the relationship of childhood abuse to psychopathology. The present cross-sectional study investigated ESS as a mediator from childhood emotional abuse (CEA), childhood sexual abuse (CSA), and childhood physical abuse (CPA) to fear and distress in a sample of 610 undergraduate students. Indirect paths were estimated through overall ESS, and through the individual domains of ownership, agency, and narrative. Disturbances to ESS mediated the relationship of both CEA and CPA to fear and distress, with particularly robust indirect paths observed for CEA. CEA demonstrated strong effects on all three ESS domains, while more modest paths appeared from CSA to narrative and from CPA to ownership and agency. Significant indirect effects emerged from both CEA and CPA through agency to distress, and from CEA and CSA through narrative to distress and fear. In both models, direct paths remained from CEA and CSA to distress only. These findings suggest that childhood abuse undermines the formation of an integrated sense of self, and that role of ESS in the pathway from childhood abuse to internalizing symptomatology may be restricted to the agency and narrative domains. Additional research should clarify the mechanisms by which childhood abuse types may disrupt ESS.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119698"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal warmth and depressive symptoms in children: The mediating role of children's responses to positive affect and the moderating role of peer emotion regulation","authors":"Liuhua Ying,&nbsp;Shuang Zhang","doi":"10.1016/j.jad.2025.119713","DOIUrl":"10.1016/j.jad.2025.119713","url":null,"abstract":"<div><div>Although poor negative emotion regulation is a known risk factor for childhood depression, the potential role of positive emotion regulation—particularly in interaction with maternal warmth and peer socialization in Chinese cultural contexts—remains understudied. This study explored whether children's responses to positive affect may mediate the relationship between maternal warmth and depressive symptoms, and whether peer emotion regulation might moderates these pathways. Participants included 489 Chinese children (<em>M</em> age = 11.06 years, <em>SD</em> = 1.22; 51.7 % female) who completed self-report measures of all main variables. Results showed a direct negative association between maternal warmth and child depressive symptoms, with two potential indirect pathways: positive rumination appeared linked to reduced symptoms, while dampening was associated with increased symptoms. Peer emotion regulation seemed to moderate only the positive mediation pathway, with the buffering effect of positive rumination on depressive symptoms appearing stronger when peer regulation was high. In contrast, the direct protective effect of maternal warmth was more pronounced at lower levels of peer regulation. These preliminary findings suggest that both children's responses to positive affect and peer emotional regulation may influence the extent to which maternal warmth is associated with reduced depressive symptoms. The results tentatively support the value of family-based interventions that target maternal warmth and adaptive positive rumination, especially when combined with peer-supported emotion regulation strategies, as a multi-system approach to alleviating childhood depressive symptoms.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119713"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating and forecasting global burden of mental disorders attributable to childhood sexual abuse or intimate partner violence: An analysis for the Global Burden of Disease Study 2021","authors":"Ke-chen Xu ,&nbsp;Ying Xie ,&nbsp;Fang Chu ,&nbsp;Meng-ting Li ,&nbsp;Ze-qi Hao ,&nbsp;Collins Opoku Antwi ,&nbsp;Peter Darko Adjei ,&nbsp;Zi-yi Li ,&nbsp;Jun Ren","doi":"10.1016/j.jad.2025.119717","DOIUrl":"10.1016/j.jad.2025.119717","url":null,"abstract":"<div><h3>Background</h3><div>As a leading global disease burden, mental disorders require critical assessment of related risk factors through disability-adjusted life years (DALYs) and years lived with disability (YLDs) to understand their public health impact.</div></div><div><h3>Methods</h3><div>With the data available from 2021 Global Burden of Disease (GBD), we mainly focused on the effect of childhood sexual abuse (CSA) and intimate partner violence (IPV) on global burden of mental disorders. We estimated numbers and the age-standardized rate (ASR) of DALYs/YLDs by sex, age, socio-demographic index (SDI), and country, and calculated the estimated annual percentage change (EAPC). Moreover, we forecasted the DALYs/YLDs using the autoregressive integrated moving average (ARIMA) model from 2022 to 2050.</div></div><div><h3>Findings</h3><div>From 1990 to 2021, the ASR of CSA-attributable DALYs/YLDs has declined from 18.25 (95 % uncertainty interval [UI] 9.04–31.13) to 18.08 (95%UI 8.75–30.97) per 100,000 population, while IPV-attributable ASR increased to 33.57 (95%UI 0.11–73.57) during the COVID-19 pandemic. In 2021, the highest DALYs/YLDs rate was observed in the 40–45 age group. Females exhibited a higher number and ASR of DALYs/YLDs attributable to CSA than males, and as the sole victims of IPV, they are projected to experience a decline in both metrics from 2022 to 2050. Low-SDI regions consistently had the highest ASR of DALYs and YLDs. India, China, and the U.S. bear the greatest burden, with the U.S. showing the highest increasing trend (EAPC: 1.54 [95%UI 1.25–1.83]), while China exhibited a decline (EAPC: −1.88 [95%UI -2.14 to −1.61]).</div></div><div><h3>Conclusions</h3><div>CSA and IPV are key risk factors for mental disorders. The burden imposed on women often attracted more attention in the past, but we see a rising trend in CSA in men. Certain countries like Singapore are doing well while others are struggling. Cross-country learning is thus put forward as important in managing CSA and IPV and their attendant mental disorders.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"389 ","pages":"Article 119717"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}