Journal of affective disorders最新文献

{"title":"Trends and determinants of prescription of lithium and antidepressants for bipolar disorder in a large health care system between 2017 and 2022","authors":"C.M. Steger ,&nbsp;B. Birckhead ,&nbsp;S. Raghunath ,&nbsp;J. Straub ,&nbsp;S. Sthapit ,&nbsp;M.C. Albert ,&nbsp;F. Goes ,&nbsp;P.P. Zandi","doi":"10.1016/j.jad.2025.04.006","DOIUrl":"10.1016/j.jad.2025.04.006","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies raised concerns about declining use of lithium and increased use of antidepressants in treatment of bipolar disorder (BP). We describe recent trends in prescription of psychotropic medications for BP and examine demographic, socioeconomic and clinical factors associated with their prescription.</div></div><div><h3>Methods</h3><div>We analyzed data from the electronic health records on 12,824 patients with BP in a large academic health system between 2017 and 2022. We calculated annual prescription rates for BP medications, and then used logistic regression to examine factors associated with their prescription.</div></div><div><h3>Results</h3><div>We found a modest increase in lithium prescription and a slight decrease for antidepressants. Lithium was prescribed to 27 % of patients, while antidepressants were prescribed to 52 % of patients, nearly half without a concomitant mood stabilizer. Patients who were Black (odds ratio [OR] = 0.70 95 % confidence interval [CI] = 0.65–0.76), had public insurance (OR = 0.87, 95 % CI = 0.81–0.94), lived in areas of higher social deprivation (OR = 0.84, 95 % CI = 0.76–0.93), or were seen in primary care (OR = 0.21, 95 % CI = 0.17–0.24) were less likely to be prescribed lithium. Patients who lived in areas of greater deprivation (OR = 1.42, 95 % CI = 1.20–1.68), were older (60+; OR = 2.64, 95 % CI = 1.96–3.58), and were seen in primary care (OR = 7.46, 95 % CI = 6.43–8.66) were more likely to be prescribed antidepressants without a concomitant mood stabilizer.</div></div><div><h3>Conclusions</h3><div>Lithium remains underutilized even though it is a first-line treatment for BP, especially among certain sub-groups. Antidepressants are widely used to treat BP, often without mood stabilizers despite caution by most clinical guidelines. These findings underscore the need for continued efforts to promote use of best evidence-treatments for BP and reduce disparities in their use.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis” [Journal of affective disorders, 322 (2023), 194-204]","authors":"Kwonmok Ko ,&nbsp;Emma I. Kopra ,&nbsp;Anthony J. Cleare ,&nbsp;James J. Rucker","doi":"10.1016/j.jad.2025.03.145","DOIUrl":"10.1016/j.jad.2025.03.145","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 825-827"},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic dissection of treatment-resistant depression with proxy phenotypes in the UK Biobank","authors":"Ling-Hua Wang ,&nbsp;Mu-Yi Shih ,&nbsp;Yen-Feng Lin ,&nbsp;Po-Hsiu Kuo ,&nbsp;Yen-Chen A. Feng","doi":"10.1016/j.jad.2025.04.012","DOIUrl":"10.1016/j.jad.2025.04.012","url":null,"abstract":"<div><h3>Background</h3><div>Treatment-resistant depression (TRD) affects one-third of major depressive disorder (MDD) patients. Previous pharmacogenetic studies suggest genetic variation may influence medication response but findings are heterogeneous. We conducted a comprehensive genetic investigation using proxy TRD phenotypes (TRD_<em>p</em>) that mirror the treatment options of MDD from UK Biobank primary care records.</div></div><div><h3>Methods</h3><div>Among 15,125 White British MDD patients, we identified TRD_<em>p</em> with medication changes (switching or receiving multiple antidepressants [AD]); augmentation therapy (antipsychotics; mood stabilizers; valproate; lithium); or electroconvulsive therapy (ECT). Hospitalized TRD_<em>p</em> patients (HOSP-TRD_<em>p</em>) were also identified. We conducted genome-wide association analysis, estimated SNP-heritability (<span><math><msubsup><mi>h</mi><mi>g</mi><mn>2</mn></msubsup></math></span>), and assessed the genetic burden for nine psychiatric diseases using polygenic risk scores (PRS).</div></div><div><h3>Results</h3><div>TRD_<em>p</em> patients were more often female, unemployed, less educated, and had higher BMI, with hospitalization rates twice as high as non-TRD_<em>p</em>. While no credible risk variants emerged, heritability analysis showed significant genetic influence on TRD_<em>p</em> (liability <span><math><msubsup><mi>h</mi><mi>g</mi><mn>2</mn></msubsup></math></span> 21–24 %), particularly for HOSP-TRD_<em>p</em> (28–31 %). TRD_<em>p</em> classified by AD changes and augmentation carried an elevated yet varied polygenic burden for MDD, ADHD, BD, and SCZ. Higher BD PRS increased the likelihood of receiving ECT, lithium, and valproate by 1.27–1.80 fold. Patients in the top 10 % PRS relative to the average had a 12–36 % and 24–51 % higher risk of TRD_<em>p</em> and HOSP-TRD_<em>p</em>, respectively.</div></div><div><h3>Conclusions</h3><div>Our findings support a significant polygenic basis for TRD, highlighting genetic and phenotypic distinctions from non-TRD. We demonstrate that different TRD_<em>p</em> endpoints are enriched with various spectra of psychiatric genetic liability, offering insights into pharmacogenomics and TRD's complex genetic architecture.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 350-359"},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of leptin, insulin, orexin, neuropeptide y (NPY) levels in postmortem CSF samples in suicide deaths","authors":"Mehmet Tokdemir ,&nbsp;Esra Erbak ,&nbsp;Ferhat Turgut Tunçez ,&nbsp;Ferhan Elmali ,&nbsp;Huriye Erbak Yilmaz","doi":"10.1016/j.jad.2025.04.015","DOIUrl":"10.1016/j.jad.2025.04.015","url":null,"abstract":"<div><h3>Background</h3><div>Suicide remains a significant global public health issue. According to the World Health Organization (WHO), suicide was the third leading cause of mortality among individuals aged 15–29 in 2021, with a total of approximately 726,000 cases reported annually. The etiology of suicide is complex, involving a combination of biological, genetic, and environmental factors, as well as family history, gender, age, personality traits, cultural background, geographic location, medical conditions, mental illnesses, addictions, and psychosocial stressors. Dysregulation of the Hypothalamic Pituitary Adrenal (HPA) axis and the effects of chronic stress play significant roles in the pathophysiology of mood disorders and suicidal behavior.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the levels of Neuropeptide Y (NPY), Orexin, Leptin, and Insulin in cerebrospinal fluid (CSF) samples of individuals who died by suicide compared to those who died from non-suicidal causes.</div></div><div><h3>Method</h3><div>The study examined 35 cases of suicide by hanging and 35 cases of non-suicidal deaths unrelated to head trauma. Levels of NPY, Orexin, Leptin, and Insulin in CSF samples collected during toxicological examinations were compared between suicide and control groups.</div></div><div><h3>Results</h3><div>NPY levels were significantly higher in the suicide group than in the control group (<em>p</em> &lt; 0.001). No statistically significant differences were found in Orexin (<em>p</em> = 0.194), Insulin (<em>p</em> = 0.892), or Leptin (<em>p</em> = 0.445) levels between the groups.</div></div><div><h3>Conclusions</h3><div>While no definitive biomarkers for diagnosing or predicting suicidal behavior exist, this panel of biomarkers could provide valuable insights for developing targeted treatments to manage patients at risk.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 303-309"},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-driven analyzes of open-ended responses to assess outcomes of internet-based cognitive behavioral therapy (ICBT) in adolescents with anxiety and depression comorbidity","authors":"Danilo Garcia ,&nbsp;Alexandre Granjard ,&nbsp;Loïs Vanhée ,&nbsp;Matilda Berg ,&nbsp;Gerhard Andersson ,&nbsp;Marta Lasota ,&nbsp;Sverker Sikström","doi":"10.1016/j.jad.2025.04.003","DOIUrl":"10.1016/j.jad.2025.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>Although patients prefer describing their problems using words, mental health interventions are commonly evaluated using rating scales. Fortunately, recent advances in natural language processing (i.e., AI-methods) yield new opportunities to quantify people's own mental health descriptions. Our aim was to explore whether responses to open-ended questions, quantified using AI, provide additional value in measuring intervention outcomes compared to traditional rating scales.</div></div><div><h3>Method</h3><div>Swedish adolescents (<em>N</em> = 44) who received Internet-based Cognitive Behavioral Therapy (ICBT) for eight weeks completed (pre/post) scales measuring anxiety and depression and three open-ended questions (related to depression, anxiety and general mental health). The language responses were quantified using a large language model and quantitative methods to predict mental health as measured by rating scales, valence (i.e., words' positive/negative affectivity), and semantic content (i.e., meaning).</div></div><div><h3>Results</h3><div>Similar to the rating scales, language measures revealed statistically significant health improvements between pre and post measures such as reduced depression and anxiety symptoms and an increase in the use of words conveying positive emotions and different meanings (e.g., pre-intervention: “anxious”, depressed; post-intervention: “happy”, “the future”). Notably, the health changes identified through semantic content measures remained statistically significant even after accounting for the changes captured by the rating scales.</div></div><div><h3>Conclusion</h3><div>Language responses analyzed using AI-methods assessed outcomes with fewer items, demonstrating effectiveness and accuracy comparable to traditional rating scales. Additionally, this approach provided valuable insights into patients' well-being beyond mere symptom reduction, thus highlighting areas of improvement that rating scales often overlook. Since patients often prefer using natural language to express their mental health, this method could complement, and address comprehension issues associated fixed-item questionnaires.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental monitoring and adolescent suicidality: Exploring differences by sex in the 2021 national survey on drug use and health","authors":"Mitch T. Strahlman,&nbsp;Priya B. Thomas,&nbsp;Ethan T. Hunt,&nbsp;Dale S. Mantey","doi":"10.1016/j.jad.2025.03.170","DOIUrl":"10.1016/j.jad.2025.03.170","url":null,"abstract":"<div><h3>Background</h3><div>Suicide is the second leading cause of death for adolescents in the U.S. Existing research demonstrates an inverse relationship between perceived parental monitoring and suicidal ideation among youth. The purpose of this study is to examine the relationship between parental monitoring and suicidality by sex among adolescents with the 2021 National Survey on Drug Use and Health (NSDUH).</div></div><div><h3>Methods</h3><div>Participants were <em>n</em> = 10,055 youth (12–17 years old; 48.18 % female). We examined the relationship between parental monitoring and two measures of suicidality (ideation; planned attempts). Models controlled for sex, age, race/ethnicity, past 30-day alcohol use, household income, and past 12-month major depressive episode. We tested for sex differences in this association via interaction models (sex ∗ perceived parental monitoring) and conducted sex-stratified models.</div></div><div><h3>Results</h3><div>Approximately 13.1 % of participants reported suicidal ideations and 6.0 % reported planning a suicide attempt. Every unit increase in perceived parental monitoring was associated with significantly lower odds of reporting suicidal ideations (aRRR: 0.89; 95 % CI: 0.87–0.91) and planned attempts (aRRR: 0.87; 95 % CI: 0.84–0.91). In sex-stratified models, the association between perceived parental monitoring and suicidal ideations was significantly (<em>p</em> = .012) stronger among females (aRRR: 0.86; 95 % CI: 0.84–0.89) relative to males (aRRR: 0.92; 95 % CI: 0.88–0.97); the same was observed for planned attempts among females (aRRR: 0.84; 95 % CI: 0.80–0.88) relative to males (aRRR: 0.92; 95 % CI: 0.85–0.99).</div></div><div><h3>Discussion</h3><div>Future research should examine dyadic assessments of both adolescent and parental appraisals of parental monitoring, and adolescent suicide prevention interventions should integrate mechanisms involving perceived parental monitoring.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 9-15"},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal depression recognition and analysis: Facial expression and body posture changes via emotional stimuli","authors":"Yang Liu ,&nbsp;Xingyun Li ,&nbsp;Mengqi Wang ,&nbsp;Jianlu Bi ,&nbsp;Shaoqin Lin ,&nbsp;Qingxiang Wang ,&nbsp;Yanhong Yu ,&nbsp;Jiayu Ye ,&nbsp;Yunshao Zheng","doi":"10.1016/j.jad.2025.03.155","DOIUrl":"10.1016/j.jad.2025.03.155","url":null,"abstract":"<div><h3>Background</h3><div>Clinical studies have shown that facial expressions and body posture in depressed patients differ significantly from those of healthy individuals. Combining relevant behavioral features with artificial intelligence technology can effectively improve the efficiency of depression detection, thereby assisting doctors in early identification of patients. This study aims to develop an end-to-end multimodal recognition model combining facial expressions and body posture via deep learning techniques, enabling rapid preliminary screening of depression.</div></div><div><h3>Methods</h3><div>We invited 146 subjects (73 in the patient group and 73 in the control group) to participate in an emotion-stimulus experiment for depression recognition. We focused on differentiating depression patients from the control group by analyzing changes in body posture and facial expressions under emotional stimuli. We first extracted images of body position and facial emotions from the video, then used a pre-trained ResNet-50 network to extract features. Additionally, we analyzed facial expression features using OpenFace for sequence analysis. Subsequently, various deep learning frameworks were combined to assess the severity of depression.</div></div><div><h3>Results</h3><div>We found that under different stimuli, facial expression units AU04, AU07, AU10, AU12, AU17, and AU26 had significant effects in the emotion-stimulus experiment, with these features generally being negative. The decision-level fusion model based on facial expressions and body posture achieved excellent results, with the highest accuracy of 0.904 and an F1 score of 0.901.</div></div><div><h3>Conclusions</h3><div>The experimental results suggest that depression patients exhibit predominantly negative facial expressions. This study validates the emotion-stimulus experiment, demonstrating that combining facial expressions and body posture enables accurate preliminary depression screening.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms and work in Indigenous people","authors":"Brett Shannon ,&nbsp;Kirsten S. Almberg ,&nbsp;Courtney Ryder ,&nbsp;Tessa Bonney ,&nbsp;Linda Forst ,&nbsp;Lee S. Friedman","doi":"10.1016/j.jad.2025.04.007","DOIUrl":"10.1016/j.jad.2025.04.007","url":null,"abstract":"<div><h3>Background</h3><div>Adverse social and environmental factors outside of the health system play an important role in disparate mental health (MH) outcomes, including access to quality employment. American Indian/Alaskan Native (AIAN) workers are at risk but have been left out of research.</div></div><div><h3>Aim</h3><div>To describe the characteristics of AIAN adults with depressive symptoms and to examine their sociodemographic, health, functional and disability characteristics by work status.</div></div><div><h3>Methods</h3><div>Utilizing the National Health Interview Survey (NHIS) data for years 2020 and 2022, we evaluated differences in MH symptoms, diagnoses, and treatment between working and non-working AIAN adults. We undertook a descriptive analysis of socio-demographic and health characteristics. Three sets of multivariable logistic regression models were undertaken to (1) evaluate the association between employment status and MH outcomes, (2) associations with MH outcomes in working AIAN adults, (3) associations with mental health outcomes in non-working AIAN adults.</div></div><div><h3>Results</h3><div>AIAN adults not currently employed had higher odds (1.55, 95%CI:1.03–2.33) of reporting weekly/daily depressive symptoms and ever being diagnosed with depression (1.50, 95%CI:1.02–2.21) compared to employed AIAN adults. Predictors of MH health outcomes differed between working and non-working AIAN adults, including age, education level, location, health care usage and delay of MH treatment.</div></div><div><h3>Conclusions</h3><div>There is evidence of the impact of work on the MH of indigenous people. An occupational health agenda should include better survey tools, and engagement with AIAN communities, workers, employers and health services to build on the evidence and support local level strategies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 329-336"},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating depression severity in narrative clinical notes using large language models","authors":"Thomas H. McCoy,&nbsp;Victor M. Castro,&nbsp;Roy H. Perlis","doi":"10.1016/j.jad.2025.04.014","DOIUrl":"10.1016/j.jad.2025.04.014","url":null,"abstract":"<div><h3>Background</h3><div>Depression treatment guidelines emphasize measurement-based care using patient-reported outcome measures, yet their impact on narrative documentation quality remains underexplored.</div></div><div><h3>Methods</h3><div>We sampled 15,000 narrative clinical outpatient notes from the electronic health record of a large academic medical center, reflecting visits between January 2, 2019 and January 30, 2024, for which a 9-item Patient Health Questionnaire (PHQ-9) was completed at the same time. After censoring PHQ-9 scores from notes, we estimated severity of depressive symptoms with a foundational large language model (gpt4o-08-06) in a HIPAA-compliant enclave. We estimated correlation between true PHQ-9 and model-estimated score and examined the predictive performance of the model for moderate or greater depressive symptoms.</div></div><div><h3>Results</h3><div>Mean age was 46.3 years (SD 14.9); 9083 (60.6 %) identified as female. 925 (6.2 %) identified as Asian, 638 (4.3 %) as Black, 853 (5.7 %) as another race, and 12,187 (81.2 %) as White. A total of 1044 (7.0 %) identified as Hispanic ethnicity, while 12,699 (84.7 %) were non-Hispanic. Mean measured PHQ-9 score was 1.23 (SD 3.45); 721 (4.8 %) met criteria for moderate or greater depressive symptoms. LLM-predicted PHQ-9 scores were modestly correlated with actual scores (r² = 0.264 (95 % CI 0.252–0.276)); PPV for moderate or greater depression was 0.309 (95 % CI 0.302–0.317). Performance was consistent across demographic subgroups, with modest differences identified by race, ethnicity, and sex.</div></div><div><h3>Conclusion</h3><div>A foundational LLM performed poorly but consistently across subgroups in imputing PHQ-9 scores from notes when actual PHQ-9 reporting was ablated. This result suggests the extent to which inclusion of PROMs may impoverish documentation of psychiatric symptoms.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 270-274"},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer problems and prosocial behaviours across development: Associations with anxiety and depression in emerging adulthood","authors":"Geneviève Morneau-Vaillancourt ,&nbsp;Alex S.F. Kwong ,&nbsp;Katherine N. Thompson ,&nbsp;Megan Skelton ,&nbsp;Ellen J. Thompson ,&nbsp;Elham Assary ,&nbsp;Celestine Lockhart ,&nbsp;Olakunle Oginni ,&nbsp;Elisavet Palaiologou ,&nbsp;Thomas McGregor ,&nbsp;Louise Arseneault ,&nbsp;Thalia C. Eley","doi":"10.1016/j.jad.2025.04.010","DOIUrl":"10.1016/j.jad.2025.04.010","url":null,"abstract":"<div><div>Peer problems in childhood and adolescence are associated with anxiety and depression in emerging adulthood. However, it remains unclear whether prosocial behaviours reduce this risk and whether these associations remain after adjusting for familial factors, including genetics. The present study examined how the development of peer problems and prosocial behaviours across childhood and adolescence were associated with anxiety and depression in emerging adulthood, and whether these associations remained when using a monozygotic twin difference design. The study included up to 31,016 participants (50.4 % female) from the Twins Early Development Study (TEDS; <em>N</em> = 19,758) and the Avon Longitudinal Study of Parents and Children (ALSPAC; <em>N</em> = 11,258), with sample sizes varying across analyses based on data availability. Repeated data were collected from ages 4 to 26/28 (TEDS/ALSPAC). Results from latent growth curve and path analyses showed that higher initial levels of peer problems and prosocial behaviours in childhood, as well as more persistent peer problems and prosocial behaviours during childhood, increased risk for anxiety and depression in emerging adulthood. Associations with peer problems remained significant after adjusting for familial factors using monozygotic twin difference scores, suggesting that individual-specific experiences, like children's responses to peer problems, may explain why peer problems increase risk for later anxiety and depression. In contrast, associations with prosocial behaviours did not remain significant after adjusting for familial factors, indicating that whilst prosocial behaviours in childhood were associated with higher levels of anxiety and depression in emerging adulthood, this was largely explained by genetic or environmental factors shared within the family.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 360-371"},"PeriodicalIF":4.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}