Journal of affective disorders最新文献

{"title":"Associations of solid fuel exposure and kitchen ventilation with mental disorders in rural areas: Evidence from a prospective cohort study","authors":"Jian Zhang ,&nbsp;Caiyun Zhang ,&nbsp;Yinghao Yuchi ,&nbsp;Huangxiang Zhang ,&nbsp;Jia Qiu ,&nbsp;Xiuli Tang ,&nbsp;Han Pang ,&nbsp;Xiaotian Liu ,&nbsp;Jian Hou ,&nbsp;Chongjian Wang ,&nbsp;Yuqian Li","doi":"10.1016/j.jad.2025.119522","DOIUrl":"10.1016/j.jad.2025.119522","url":null,"abstract":"<div><div>This research aimed to investigate the relationship of rural kitchen fuel types with the risk of depression, anxiety, and SI (suicidal ideation), including the impact of kitchen ventilation. A total of 12,058 eligible participants were obtained from the Henan rural cohort study. Logistic regression analysis was conducted to examine the impact of solid fuel use on the occurrence of mental disorders, as well as the modifying effect of kitchen mechanical ventilation. After adjusting for confounding factors, solid fuel use was associated with depression, anxiety and SI with odds ratios and 95 % confidence intervals (<em>ORs</em> and 95 % <em>CIs</em>) of 1.46 (1.12, 1.89), 1.45 (1.10, 1.89), and 1.27 (0.92, 1.74), respectively. The joint effect results showed that the risks of depression, anxiety symptoms and SI increased by 1.25 (0.64, 2.09), 1.26 (0.63, 2.13) and 1.69 (0.80, 3.04) for solid fuel and natural ventilation, respectively. The interaction results showed that 46 % of the risk of depression and anxiety symptoms could be attributed to the synergistic effect of solid fuel use and natural ventilation. Stratified analyses yielded similar findings. Exposure of solid fuel is associated with increased risks of depression, anxiety, and SI, and kitchen mechanical ventilation could reduce the adverse effects of solid fuel use on mental disorders. It is suggested that kitchen mechanical ventilation may be an effective approach to ameliorate the risk of mental disorders from solid fuel exposure.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119522"},"PeriodicalIF":4.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk factors for relapse behavior in individuals with substance use disorders: An interpretable machine learning study","authors":"Jisheng Xu ,&nbsp;Xue Li ,&nbsp;Xin Liang ,&nbsp;Xuejie Zhang ,&nbsp;Guosi Ying ,&nbsp;Jun Liu","doi":"10.1016/j.jad.2025.119520","DOIUrl":"10.1016/j.jad.2025.119520","url":null,"abstract":"<div><h3>Background</h3><div>Substance abuse has become a serious public health problem worldwide, and finding effective prevention and treatment strategies is undoubtedly an urgent need. This study addresses the risk factors that lead to relapse behaviors among substance use disorders (SUDs) and provides a reference for developing appropriate prevention and treatment strategies for SUDs.</div></div><div><h3>Methods</h3><div>In this study, 5255 SUDs were collected by cluster-wide random sampling, including basic personal information, personal health, social relationships, drug abuse behaviors and characteristics, and other information collected to predict the recurrence rate. In segmenting the dataset for training and evaluating several widely used machine learning methods, the best performing eXtreme Gradient Boosting (XGboost) model is explained at different levels by SHapley Additive explanation (SHAP).</div></div><div><h3>Results</h3><div>1) The XGboost model achieved the best performance with an area under the receiver operating characteristic curve of 0.76 in the validation set. 2) Ranking of risk factors using SHAP found that drug use behaviors and characteristics were important features for the prediction of relapse behavior. 3) SHAP predicted and interpreted individual recurrence probabilities, and individuals were visualized and analyzed.</div></div><div><h3>Limitations</h3><div>This study had limited sample diversity, and suggests further research is needed to fully understand the predictors of SUD relapse.</div></div><div><h3>Conclusions</h3><div>Interpretable machine learning not only performs well in predicting relapse but also helps clinical experts and healthcare workers to better understand each risk factor and each case. It also provides a new way of thinking about recognizing the risk factors that influence relapse.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119520"},"PeriodicalIF":4.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution is the risk factor for psychiatric disorders: a two-step Mendelian randomization study","authors":"Jingying Zhou ,&nbsp;Zhe Lu ,&nbsp;Ke Xu ,&nbsp;Guorui Zhao ,&nbsp;Yunqing Zhu ,&nbsp;Rui Yuan ,&nbsp;Yaoyao Sun ,&nbsp;Yuyanan Zhang ,&nbsp;Weihua Yue","doi":"10.1016/j.jad.2025.119475","DOIUrl":"10.1016/j.jad.2025.119475","url":null,"abstract":"<div><h3>Background</h3><div>Ambient air pollution, a significant environmental health threat, has been shown to risk psychiatric disorders according to epidemiological evidence. However, the causal relationships between air pollutants and psychiatric disorders remain unclear.</div></div><div><h3>Methods</h3><div>To reveal the impact of air pollution (including nitrogen dioxide [NO₂, <em>n</em> = 456,380], particulate matter &lt;2.5 μm [PM_2.5, <em>n</em> = 423,796], and PM_2.5 absorbance [n = 423,796]) on psychiatric disorders (autism spectrum disorders [ASD, <em>n</em> = 46,351], attention-deficit/hyperactivity disorder [ADHD, <em>n</em> = 55,374], anxiety disorders [ANX, <em>n</em> = 17,310], schizophrenia [SCZ, <em>n</em> = 127,906], and major depressive disorder [MDD, <em>n</em> = 500,199]), the Mendelian Randomization (MR) analysis was conducted. The mediating effects of brain imaging phenotypes were also accessed (<em>n</em> = 8428).</div></div><div><h3>Results</h3><div>MR analysis indicated a significant effect of PM_2.5 on MDD (OR = 1.260, 95 % CI: 1.077–1.474, <em>P</em> = 0.004), which was partially mediated by the volume of left CA4-body (6.18 %) and masked by the grey-white contrast in frontalpole in the right hemisphere parcellation (4.71 %). We also observed that the significant relationship between PM_2.5 absorbance and ADHD (OR = 2.018, 95%CI: 1.250–3.258, <em>P</em> = 0.004), which was masked by rfMRI connectivity (ICA100 edge 25) (13.27 %). Furthermore, we discovered that NO₂ (OR = 1.511, 95 % CI: 1.069–2.136, <em>P</em> = 0.020) or PM_2.5 absorbance (OR = 1.595, 95 % CI: 1.078–2.361, <em>P</em> = 0.020) increased the risk of ASD. In addition, there were associations between NO₂ and SCZ (OR = 1.494, 95%CI: 1.104–2.022, <em>P</em> = 0.009) as well as PM_2.5 and ANX (OR = 2.431, 95%CI: 1.207–4.898, <em>P</em> = 0.013).</div></div><div><h3>Conclusion</h3><div>The findings revealed genetic causal relationships between air pollution and psychiatric disorders, mediated or masked by brain imaging phenotypes. These results may provide insights for mechanistic and clinical research on air pollution-mediated psychiatric disorders.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119475"},"PeriodicalIF":4.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive d-serine treatment for major depressive disorder: A randomized clinical trial","authors":"Lukas Sempach ,&nbsp;Anna-Chiara Schaub ,&nbsp;Annette B. Brühl ,&nbsp;Philipp Sterzer ,&nbsp;Undine E. Lang ,&nbsp;André Schmidt","doi":"10.1016/j.jad.2025.119504","DOIUrl":"10.1016/j.jad.2025.119504","url":null,"abstract":"<div><h3>Background</h3><div>The antidepressant effects of <em>N</em>-methyl-<span>d</span>-aspartate receptor (NMDAR) antagonists highlight glutamatergic neurotransmission as a promising therapeutic target for major depressive disorder (MDD). The NMDAR co-agonist <span>d</span>-serine, binding on the glycine site, may enhance standard treatments' efficacy while showing fewer side effects.</div></div><div><h3>Aim</h3><div>To evaluate the efficacy of <span>d</span>-serine as an adjunctive treatment for alleviating depressive symptoms, anxiety, and anhedonia in patients with moderate-to-severe MDD.</div></div><div><h3>Methods</h3><div>A six-week, randomized, double-blind, placebo-controlled clinical trial was conducted with 44 adult inpatients with moderate-to-severe MDD. Participants were randomly assigned to receive either <span>d</span>-serine (2 g/day) or placebo alongside treatment as usual (TAU). The primary outcome was the change in clinician-rated depressive symptoms (HDRS-17) from baseline to post-intervention. Secondary outcomes included self-reported depressive symptoms (BDI-II), anxiety (STAI-1), and anhedonia (SHAPS).</div></div><div><h3>Results</h3><div>Both groups exhibited significant symptom reductions across all measures by post-intervention, with no significant differences between <span>d</span>-serine and placebo in the overall sample. Subgroup analyses indicated that <span>d</span>-serine significantly improved depressive symptoms in participants with severe MDD, with a trend towards improvement in anhedonia. In the <span>d</span>-serine group, greater clinical improvements in depressive symptoms and anhedonia were correlated with higher baseline depression severity and higher TAU medication doses.</div></div><div><h3>Conclusion</h3><div>While <span>d</span>-serine did not show superior efficacy over placebo in the overall sample, it demonstrated potential as an adjunctive treatment in patients with severe MDD, particularly those receiving higher medication doses. These findings suggest that <span>d</span>-serine may provide synergistic benefits when combined with standard treatments in specific subgroups of patients with MDD.</div><div>Trial Registration at <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Identifier: <span><span>NCT04721249</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119504"},"PeriodicalIF":4.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic findings across major depressive disorder, bipolar disorder and schizophrenia: A qualitative review","authors":"Frederike Stein,&nbsp;Tilo Kircher","doi":"10.1016/j.jad.2025.119464","DOIUrl":"10.1016/j.jad.2025.119464","url":null,"abstract":"<div><div>This narrative review examines the growing body of research highlighting the transdiagnostic features of Major Psychoses, encompassing Major Depressive Disorder (MDD), Bipolar Disorder (BD), and Schizophrenia (SZ). Overlapping genetic, psychosocial risk factors, neuroimaging, cognition, course of illness, treatments and psychopathological domains challenge the traditional categorical distinctions that have long defined these disorders. Evidence reveals shared variance in these domains. Furthermore, dimensional approaches, such as the Research Domain Criteria (RDoC), Hierarchical Taxonomy of Psychopathology (HiTOP), network approaches and clinical staging, offer frameworks for understanding these disorders along a continuum rather than within rigid categorical boundaries. This review synthesizes current empirical findings across these domains and emphasizes the need for a re-evaluation of psychiatric classification systems. It argues that a transdiagnostic approach may lead to more explained variance in clinical and neurobiological research, personalized as well as effective diagnostic and treatment strategies, ultimately improving patient outcomes.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119464"},"PeriodicalIF":4.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for antidepressant medications in the maintenance phase: A systematic review and network Meta-analysis","authors":"Ziyi Pan ,&nbsp;Haonan Zhang ,&nbsp;Binghua Li ,&nbsp;Zhuoyue Huang ,&nbsp;Yingyan Hu ,&nbsp;Jun Chen ,&nbsp;Raymond W. Lam ,&nbsp;Yiru Fang","doi":"10.1016/j.jad.2025.119460","DOIUrl":"10.1016/j.jad.2025.119460","url":null,"abstract":"<div><h3>Background</h3><div>In the management of depression, achieving and maintaining remission is crucial. This study aims to compare and rank the effectiveness of several antidepressant medication strategies for patients with depression in the maintenance phase.</div></div><div><h3>Methods</h3><div>We included randomized controlled trials (RCTs) by searching MEDLINE, EMBASE, PsycINFO, CENTRAL, CINAHL, PubMed and Web of Science. We included studies comparing at least two of the five treatment strategies: continuing the current antidepressant at the same dose; reducing the antidepressant dose; increasing the antidepressant dose; switching to another antidepressant; stopping and replacing the antidepressant with placebo. A standard random-effects network meta-analysis (NMA) was used to synthesize data. The study protocol was registered with PROSPERO, number CRD42023417283.</div></div><div><h3>Results</h3><div>A total of 24 studies with 6055 individuals were included for analysis. All strategies outperformed stopping medication in relapse prevention. Specifically, continuing the same dose (RR 0.54; 95 % CI, 0.48–0.60), reducing dose (RR 0.49; 95 % CI, 0.34–0.72), increasing dose (RR 0.53; 95 % CI, 0.34–0.82), and switching to another antidepressant (RR 0.64; 95 % CI, 0.48–0.84) demonstrated significant efficacy.</div></div><div><h3>Conclusion</h3><div>These results suggest that continuing and reducing dose may show good performance in terms of efficacy, tolerability, and acceptability for patients with depression in the maintenance phase. Increased dose doesn't reduce efficacy but patients are more likely to interrupt treatment. Switching has moderate efficacy and acceptability, but the risk of adverse events is higher. Due to the limited number of included studies, further research is needed to determine these results.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"387 ","pages":"Article 119460"},"PeriodicalIF":4.9,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impacts of low back pain and sleep duration on the long-term change in depressive symptoms among middle-aged and older Chinese adults","authors":"Peixuan Shen ,&nbsp;Zhen Zhao ,&nbsp;Rongrong Guo ,&nbsp;Xiaochuan Lu ,&nbsp;Shengnan Liu ,&nbsp;Meiyue Shen ,&nbsp;Tingwei Du ,&nbsp;Xiaoli Shen","doi":"10.1016/j.jad.2025.119476","DOIUrl":"10.1016/j.jad.2025.119476","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to explore the individual and combined effect of low back pain (LBP) and nighttime sleep duration (NSD) on depressive symptoms (DS), as well as to examine whether these associations were modified by daytime napping.</div></div><div><h3>Methods</h3><div>Data from 5588 participants in the China Health and Retirement Longitudinal Study (2011–2018) were analyzed. Generalized estimating equation models were fitted to explore the individual and combined effects of baseline LBP and NSD on subsequent DS scores. The Cox proportional hazards regression model was employed to assess the combined effect of LBP and NSD on DS. Subgroup analyses were performed to explore whether these associations differed by daytime napping.</div></div><div><h3>Results</h3><div>During a mean follow-up of 5.95 years, 2427 participants developed DS. Simultaneous exposure to LBP and short NSD significantly increased DS scores from visit 2 (<em>β</em> = 3.711, 95 % CI = 3.040–4.383) to visit 4 (<em>β</em> = 5.353, 95 % CI = 4.555–6.151), with the fastest increasing rate. The hazard ratio (HR) with 95 % CI for DS incidence was 2.028 (1.721, 2.390) among participants with LBP and short NSD. Subgroup analyses showed that daytime nappers with LBP and long NSD did not significantly increase the DS scores from visit 2 (<em>β</em> = 1.087, <em>P</em> = 0.390) to visit 4 (<em>β</em> = 2.934, <em>P</em> = 0.126).</div></div><div><h3>Conclusions</h3><div>LBP and short NSD predict higher DS scores and the risk of DS, while daytime napping may reduce the risk of DS among individuals with LBP and long NSD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"386 ","pages":"Article 119476"},"PeriodicalIF":4.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint association of physical activity and dietary quality on mortality risk in individuals with depression: a population-based cohort study","authors":"Shengying Liu ,&nbsp;Shuiqing Qin ,&nbsp;Xiaoxi Zhu ,&nbsp;Qiuzhen Qin ,&nbsp;Mei He ,&nbsp;Xuezhi Yang ,&nbsp;Jingmei Tang ,&nbsp;Binfeng Zhang ,&nbsp;Qinyao Guo ,&nbsp;Jianghao Yuan ,&nbsp;Yusheng Tian ,&nbsp;Qiang Lu ,&nbsp;Jiansong Zhou","doi":"10.1016/j.jad.2025.119456","DOIUrl":"10.1016/j.jad.2025.119456","url":null,"abstract":"<div><h3>Background</h3><div>Depression affects about 5 % of the global adult population and increases mortality. Physical activity (PA) and dietary quality (DQ) are both related to depression and mortality. However, there is limited research on the combined effects of PA and DQ among individuals with depression. This study will examine the separate and combined effects of PA and DQ on mortality in this population.</div></div><div><h3>Methods</h3><div>The data of 5443 individuals with depression were derived from the National Health and Nutrition Examination Survey from 2007 to 2018, a cross-sectional study since 1990. The outcomes of the study included all-cause, cardiovascular disease (CVD), and non-CVD mortality. PA was measured using the Global Physical Activity Questionnaire, while DQ was assessed via the Healthy Eating Index-2020. Cox proportional hazards regression models and restricted cubic splines were employed to determine how PA and DQ independently and jointly affect mortality.</div></div><div><h3>Results</h3><div>Joint analyses revealed that individuals with depression who engaged in active PA and qualified DQ were associated with lower risk of all-cause (HR 0.47 [0.30, 0.71], <em>P</em> &lt; 0.001) and non-CVD mortality (HR 0.43 [0.25, 0.75], <em>P</em> = 0.003) compared with lifestyle intervention alone. However, active PA and qualified DQ were not significantly associated with CVD mortality (HR 0.57 [0.30, 1.10], <em>P</em> = 0.089).</div></div><div><h3>Conclusion</h3><div>The study shows that combining active PA and qualified DQ significantly reduces all-cause and non-CVD mortality risk among individuals with depression. This suggests that integrating PA and dietary interventions could be a promising way to improve health outcomes for this population.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"386 ","pages":"Article 119456"},"PeriodicalIF":4.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the 2-week postpartum health checkup for term deliveries prevent postpartum depression? Analysis using a 10-year database from a university hospital in Japan.","authors":"Maiko Kawajiri, Fuyuko Saito, Yoko Takeishi, Hiroko Mori, Kazumi Chiba, Takako Odaira, Masatoshi Saito, Mikako Yoshida","doi":"10.1016/j.jad.2025.119459","DOIUrl":"https://doi.org/10.1016/j.jad.2025.119459","url":null,"abstract":"<p><strong>Background: </strong>Postpartum depression (PPD) is a significant public health concern with adverse outcomes for both mothers and offspring. This study examined the association between a two-week postpartum health checkup (HC) and PPD prevalence at one month.</p><p><strong>Methods: </strong>This retrospective cohort study from Japan included 6681 women who delivered full-term singleton babies between January 1, 2012, and August 31, 2021. The HC group received a two-week HC from January 2019, whereas those who delivered before this period were in the non-HC (control) group. PPD was assessed using the Japanese version of the Edinburgh Postnatal Depression Scale (EPDS) at discharge and one month postpartum. Logistic regression analysis identified factors associated with an EPDS score ≥ 9 at one month postpartum.</p><p><strong>Results: </strong>The average maternal age of participants was 32.5 ± 5.6 years; 51.8 % (n = 3463) were primiparous, and 27.8 % (n = 1856) were in the HC group. The HC group demonstrated a significantly lower proportion of women with EPDS score ≥ 9 at one month postpartum than the non-HC group (8.9 % vs. 13.8 %, p < 0.001). Factors associated with an EPDS score ≥ 9 at one month postpartum included attending the two-week postpartum HC (adjusted odds ratio [aOR] = 0.502, p < 0.001), EPDS score at discharge (aOR = 5.574, p < 0.001), psychiatric disorder history (aOR = 2.732, p < 0.001), cesarean section (aOR = 0.762, p = 0.006), and exclusive formula feeding (aOR = 1.368, p = 0.005).</p><p><strong>Conclusion: </strong>Two-week postpartum HC was associated with a lower prevalence of PPD risk at one month postpartum. Early postpartum HC may be valuable for identifying women at risk of PPD and supporting timely interventions.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119459"},"PeriodicalIF":4.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding:‘Association between maternal stress patterns and neonatal meconium microbiota: A prospective cohort study’","authors":"Liqiu Kou","doi":"10.1016/j.jad.2025.119455","DOIUrl":"10.1016/j.jad.2025.119455","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"386 ","pages":"Article 119455"},"PeriodicalIF":4.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}